Hani Kushlaf

Hani Kushlaf , MD

Associate Professor of Clinical

Director of the Neuromuscular Medicine Fellowship, Director of Neuromuscular Research

Stetson Building
260 Stetson Street
Cincinnati, Ohio 45219
Phone 513-558-1753
Email hani.kushlaf@uc.edu

Education

Medical Degree: University of Tripoli School of Medicine Tripoli, LB, 2002

Internship: University of Kentucky Lexington, KY, 2006 (Internal Medicine)

Residency: University of Kentucky Lexington, KY, 2008 (Neurology)

Residency: University of Kentucky Lexington, KY, 2009 (Neurology- Chief Resident)

Fellowship: Mayo Clinic Rochester, MN, 2010 (Muscle Disease )

Fellowship: Mayo Clinic Rochester, MN, 2011 (Peripheral Nerve Disorders)

Fellowship: Duke University Medical Center Durham, NC, 2012 (Advanced Neuromuscular Medicine)

Certifications

American Board of Electrodiagnostic Medicine (Certification Date: 04-13-2013 )

American Board of Psychiatry and Neurology (Neurology) (Certification Date: 09-28-2009 ) - (Recertification Date: to 12-15-2019 )

United Council for Neurologic Subspecialties (Certification Date: 08-15-2015 )

American Board of Psychiatry and Neurology (Neuromuscular Medicine) (Certification Date: 08-15-2011 ) - (Recertification Date: to 01-15-2022 )

Clinical Interests

Neurology

Acute Inflammatory Demyelinating Polyradiculoneuropathy

Alcoholic Neuropathy

ALS (Lou Gehrig's Disease)

Amyloid Neuropathies

Atrophic Muscular Disorders

Autonomic Neuropathy

Brachial Plexus Injury

Brachial Plexus Neuropathies

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Congenital Myasthenic Syndromes (CMS)

Diabetic Neuropathies

Distal Myopathies

Duchenne Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy

Foot Drop

Frontalis Interna Hyperostosis

Hyperkalemic Periodic Paralysis

Hypokalemic Periodic Paralysis

Isaacs Syndrome

Kearns-Sayre Syndrome

Limb-Girdle Muscular Dystrophies

Mad Cow Disease (Creutzfeldt-Jakob disease)

MELAS Syndrome

Memory Disorders

MERRF Syndrome

Metabolic Brain Disease

Mild Cognitive Impairment

Mitochondrial Myopathies

Mononeuropathies

Motor Neuron Disease

Muscle Hypertonia

Muscle Weakness

Muscular Atrophy

Myasthenia Gravis

Myopathy

Myophosphorylase Deficiency (McArdle Disease)

Myositis

Myotonia

Myotonia Congenita

Myotonic Disorders

Myotonic Dystrophy

Nemaline Myopathies

Nerve Compression Syndromes

Nerve Pain

Nerve Pain Syndromes

Neuritis

Neurofibroma

Neurofibromatosis

Neurofibromatosis II

Neurogenic Inflammation

Neuromuscular Disease

Neuromuscular Disorders

Neuromuscular Junction Disease

Neuromuscular Manifestations

Occupational Neuropathies

Paraneoplastic Polyneuropathy

Peripheral Nerve Disorders

Peripheral Nerve Injury

Peripheral Nervous System Disease

Peripheral Neuropathy

Peroneal Neuropathy

Polyneuropathies

Polyradiculoneuropathy

Polyradiculopathy

Radiculopathies

Radiculopathy

Sarcoglycanopathies

Sciatic Neuropathy

Sciatica

Specialities

Clinical Neuromuscular Pathology

Electrodiagnostic Medicine

Neurology

Neuromuscular Medicine

Research and Practice Interests

-Inherited and acquired peripheral neuropathies (including CIDP and other dysimmune neuropathies), plexopathies, myopathies, muscular dystrophies, ALS, motor neuron disorders, and neuromuscular junction disorders (myasthenia gravis and Lambert-Eaton myasthenic syndrome)
-Inclusion body myositis
-Peripheral nerve and muscle ultrasound
-Single fiber EMG and advanced EMG techniques (MUNE, MUP analysis)
-Pathology of nerve and muscle disorders
 

Positions and Work Experience

11-20-2013 - Director, Neuromuscular Medicine Fellowship, University of Cincinnati,

- Muscular Dystrophy Association Care Center Director,

- Director of Neuromuscular Research,

Research Support

Grant: #CER-1306-02496_PCORI Investigators:Kushlaf, Hani 07-01-2016 -03-31-2017 Patient-Centered Outcomes Research Institute Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS) Role:PI $62,125.00 Active Level:Private Non-Profit

Grant: #MOVR Data Hub Investigators:Kushlaf, Hani 09-01-2019 -08-31-2024 Muscular Dystrophy Association MDA MOVR Data Hub Registry Role:PI 10399.00 Hold Level:Non Profit

Grant: #MassGen Hospital / Healey Master Agreement 12-01-2021 -12-01-2026 Massachusetts General Hospital Master Site Clinical Trial MGH Role:PI 0.00 Hold Level:Non Profit

Grant: #MassGen Hospital / Healey Master Agreement 12-01-2021 -12-01-2026 Massachusetts General Hospital Master Site Clinical Trial MGH Role:PI 0.00 Hold Level:Non Profit

Investigators:Kushlaf, Hani 02-09-2022 -02-08-2025 Massachusetts General Hospital HEALEY ALS Platform Trial related to Amyotrophic Lateral Sclerosis (ALS) Role:PI 0.00 Hold Level:Non Profit

Grant: #R3918-MG-2018 Investigators:Kushlaf, Hani 12-01-2021 -11-30-2024 Regeneron Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Patients with Symptomatic Generalized Myasthenia Gravis Role:PI 354517.01 Hold Level:Industry

Grant: #EDG-5506-201 04-01-2022 -03-31-2025 EDGEWISE THERAPEUTICS, INC. A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Role:PI 205352.50 Hold Level:Industry

Grant: #EDG-5506-201 04-01-2022 -03-31-2025 EDGEWISE THERAPEUTICS, INC. A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Role:PI 205352.50 Hold Level:Industry

Grant: #08312020 v4.0 11-01-2022 -10-31-2025 Massachusetts General Hospital HEALEY ALS Task Order #1 Role:PI 19779.00 Hold Level:Non Profit

Grant: #08312020 v4.0 11-01-2022 -10-31-2025 Massachusetts General Hospital HEALEY ALS Task Order #1 Role:PI 19779.00 Hold Level:Non Profit

Investigators:Kushlaf, Hani 05-01-2022 -04-30-2025 Harmony Biosciences, LLC A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients with Myotonic Dystrop Role:PI 164226.41 Hold Level:Industry

Grant: #ALXN2050-MG-201 04-01-2022 -03-31-2025 Alexion Pharmaceuticals, Inc. A Phase 2, Randomized, Double-Blind, Placebo-Controlled Multicenter Study toEvaluate the Efficacy and Safety of ALXN2050 in Adult Participants with GeneralizedMyasthenia Gravis Role:PI 393792.93 Hold Level:Industry

Grant: #ALXN2050-MG-201 04-01-2022 -03-31-2025 Alexion Pharmaceuticals, Inc. A Phase 2, Randomized, Double-Blind, Placebo-Controlled Multicenter Study toEvaluate the Efficacy and Safety of ALXN2050 in Adult Participants with GeneralizedMyasthenia Gravis Role:PI 393792.93 Hold Level:Industry

Publications

Published Abstracts

Jonas Vanags, Hani Kushlaf, Vern Juel (02-2012. ) Post-irradiation hypoglossal and accessory neuropathies with myokymic discharges .[Abstract]North Carolina Neurological society annual meeting,

Hani Kushlaf, Vern Juel, Lisa Hobson-Webb (10-2012. ) Sonographically-measured nerve size and intra-nerve size variability in inflammatory polyneueropathy .[Abstract]Muscle&Nerve and Clinical Neurophysiology,

Hani Kushlaf, Vern Juel, Lisa Hobson-Webb (10-2012. ) Do ultrasound characteristics correlate with electrodiagnostic findings in inflammatory neuropathies? .[Abstract]Muscle&Nerve and Clinical Neurophysiology,

David Clark, Hani Kushlaf (10-16-2013. ) Macroglossia in Duchenne Muscular Dystrophy .[Abstract]Muscle&Nerve and Clinical Neurophysiology,

Julia Zhu, Hani Kushlaf (03-16-2014. ) Camptocormia as the Initial Prominent Manifestation of Myotonic Dystrophy Type I .[Abstract]

Peer Reviewed Publications

Kushlaf, Hani A; Massey, E Wayne; Hobson-Webb, Lisa (2014. ) Proximal Median Neuropathy caused by Surgical Manipulation of Masson Tumor.Muscle & nerve, , More Information

Erra, Carmen; Granata, Giuseppe; Liotta, Giovanna; Podnar, Simon; Giannini, Mauro; Kushlaf, Hani; Hobson-Webb, Lisa D; Leversedge, Fraser J; Martinoli, Carlo; Padua, Luca (2013. ) Ultrasound diagnosis of bony nerve entrapment: case series and literature review.Muscle & nerve, , 48 (3 ) ,445-50 More Information

Kushlaf, Hani A (2013. ) Emerging toxic neuropathies and myopathies.The Psychiatric clinics of North America, , 36 (2 ) ,209-18 More Information

Lee, Ikjae; Kushlaf, Hani (2018. ) Needle electromyography practice patterns in patients taking novel oral anticoagulants: A survey-based study.Muscle & nerve, , More Information

Kushlaf, Hani A (2011. ) Emerging toxic neuropathies and myopathies.Neurologic clinics, , 29 (3 ) ,679-87 More Information

Davalos, Long; Kushlaf, Hani (2018. ) New onset of seropositive generalized myasthenia gravis following intravesical Bacille Calmette-Guerin treatment for bladder cancer: A case study.Muscle & nerve, , More Information

Kushlaf, Hani (2019. ) Peripheral Neuropathy and the Ceruloplasmin Gene.Annals of internal medicine, , 170 (4 ) ,282 More Information

Kushlaf, Hani; Li, Yuebing (2019. ) The evidence is stacked against thymectomy in MuSK myasthenia gravis.Muscle & nerve, , More Information

Sandrone, Stefano; Berthaud, Jimmy V; Chuquilin, Miguel; Cios, Jacquelyne; Ghosh, Pritha; Gottlieb-Smith, Rachel J; Kushlaf, Hani; Mantri, Sneha; Masangkay, Neil; Menkes, Daniel L; Nevel, Kathryn S; Sarva, Harini; Schneider, Logan D (2019. ) Neurologic and neuroscience education: Mitigating neurophobia to mentor health care providers.Neurology, , 92 (4 ) ,174-179 More Information

Kushlaf, Hani (2020. ) DIVING INTO THE HETEROGENEITY OF INCLUSION BODY MYOSITIS.Muscle & nerve, , More Information

Barohn, Richard J; Gajewski, Byron; Pasnoor, Mamatha; Brown, Alexandra; Herbelin, Laura L; Kimminau, Kim S; Mudaranthakam, Dinesh Pal; Jawdat, Omar; Dimachkie, Mazen M ; Iyadurai, Stanley; Stino, Amro; Kissel, John; Pascuzzi, Robert; Brannagan, Thomas; Wicklund, Matthew; Ahmed, Aiesha; Walk, David; Smith, Gordon; Quan, Dianna; Heitzman, Darryl; Tobon, Alejandro; Ladha, Shafeeq; Wolfe, Gil; Pulley, Michael; Hayat, Ghazala; Li, Yuebing; Thaisetthawatkul, Pariwat; Lewis, Richard; Biliciler, Suur; Sharma, Khema; Salajegheh, Kian; Trivedi, Jaya; Mallonee, William; Burns, Ted; Jacoby, Mark; Bril, Vera; Vu, Tuan; Ramchandren, Sindhu; Bazant, Mark; Austin, Sara; Karam, Chafic; Hussain, Yessar; Kutz, Christen; Twydell, Paul; Scelsa, Stephen; Kushlaf, Hani; Wymer, James; Hehir, Michael; Kolb, Noah; Ralph, Jeffrey; Barboi, Alexandru; Verma, Navin; Ahmed, Moiz; Memon, Anza; Saperstein, David; Lou, Jau-Shin; Swenson, Andrea; Cash, Tiyonnoh (2020. ) Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial.JAMA neurology, , More Information

Kushlaf, Hani (2020. ) COVID-19 in muscle-specific kinase myasthenia gravis: A case report.Muscle & nerve, , More Information

Janecek, Jacqueline; Kushlaf, Hani (2020. ) Toxin-Induced Channelopathies, Neuromuscular Junction Disorders, and Myopathy.Neurologic clinics, , 38 (4 ) ,765-780 More Information

Kushlaf, Hani (2020. ) Cystinosis myopathy: Searching for optimal clinical outcome measures.Muscle & nerve, , More Information

Kushlaf, Hani (2021. ) Immune Profiling Beyond Antibodies in Double Seronegative and Acetylcholine Receptor Antibody Positive Myasthenia Gravis: What do we Learn?.Muscle & nerve, , More Information

Bazrafshan, Sholeh; Kushlaf, Hani; Kakroo, Mashhood; Quinlan, John; Becker, Richard C; Sadayappan, Sakthivel (2021. ) Genetic Modifiers of Hereditary Neuromuscular Disorders and Cardiomyopathy.Cells, , 10 (2 ) , More Information

Sandrone, Stefano; Albert, Dara Vf; Dunham, S Richard; Kraker, Jessica; Noviawaty, Ika; Palm, Michael; Kushlaf, Hani (2021. ) Training in Neurology: How Lessons Learned on Teaching, Well-being and Telemedicine During the COVID-19 Pandemic Can Shape the Future of Neurology Education.Neurology, , More Information

Hafeez, Komal; Kushlaf, Hani; Al-Sultani, Husam; Joseph, Anny-Claude; Zaeem, Zoya; Siddiqi, Zaeem; Laboy, Shannon; Pulley, Michael; Habib, Ali A; Robbins, Nathaniel M; Zadeh, Sean; Hafeez, Muhammad Ubaid; Hussain, Yessar; Melendez-Zaidi, Alexandria; Kassardjian, Charles; Johnson, Kristin; Leonhard, Holly; Biliciler, Suur; Patino Murillas, Jorge E; Shaibani, Aziz I (2022. ) Patient preference for virtual versus in-person visits in neuromuscular clinical practice.Muscle & nerve, , More Information

Korb, Manisha; Peck, Allison; Alfano, Lindsay N; Berger, Kenneth I; James, Meredith K; Ghoshal, Nupur; Healzer, Elise; Henchcliffe, Claire; Khan, Shaida; Mammen, Pradeep P A; Patel, Sujata; Pfeffer, Gerald; Ralston, Stuart H; Roy, Bhaskar; Seeley, William W; Swenson, Andrea; Mozaffar, Tahseen; Weihl, Conrad; Kimonis, Virginia (2022. ) Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.Orphanet journal of rare diseases, , 17 (1 ) ,23 More Information

Schoser, Benedikt; Roberts, Mark; Byrne, Barry J; Sitaraman, Sheela; Jiang, Hai; Laforêt, Pascal; Toscano, Antonio; Castelli, Jeff; Díaz-Manera, Jordi; Goldman, Mitchell; van der Ploeg, Ans T; Bratkovic, Drago; Kuchipudi, Srilakshmi; Mozaffar, Tahseen; Kishnani, Priya S (2021. ) Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial.The Lancet. Neurology, , 20 (12 ) ,1027-1037 More Information

Diaz-Manera, Jordi; Kishnani, Priya S; Kushlaf, Hani; Ladha, Shafeeq; Mozaffar, Tahseen; Straub, Volker; Toscano, Antonio; van der Ploeg, Ans T; Berger, Kenneth I; Clemens, Paula R; Chien, Yin-Hsiu; Day, John W; Illarioshkin, Sergey; Roberts, Mark; Attarian, Shahram; Borges, Joao Lindolfo; Bouhour, Francoise; Choi, Young Chul; Erdem-Ozdamar, Sevim; Goker-Alpan, Ozlem; Kostera-Pruszczyk, Anna; Haack, Kristina An; Hug, Christopher; Huynh-Ba, Olivier; Johnson, Judith; Thibault, Nathan; Zhou, Tianyue; Dimachkie, Mazen M; Schoser, Benedikt (2021. ) Safety and efficacy of avalglucosidase alfa versus alglucosidase alfa in patients with late-onset Pompe disease (COMET): a phase 3, randomised, multicentre trial.The Lancet. Neurology, , 20 (12 ) ,1012-1026 More Information

Kushlaf, Hani; Li, Yuebing (2021. ) How does rituximab fit in the treatment algorithm of myasthenia gravis?.Muscle & nerve, , 64 (6 ) ,635-636 More Information

Kushlaf, Hani; Ezzat, Kariem (2021. ) Extracellular amyloid deposition in sporadic inclusion body myositis: Further insights.Muscle & nerve, , 64 (5 ) ,517-519 More Information

Schiava, Marianela; Ikenaga, Chiseko; Villar-Quiles, Rocío Nur; Caballero-Ávila, Marta; Topf, Ana; Nishino, Ichizo; Kimonis, Virginia; Udd, Bjarne; Schoser, Benedikt; Zanoteli, Edmar; Souza, Paulo Victor Sgobbi; Tasca, Giorgio; Lloyd, Thomas; Lopez-de Munain, Adolfo; Paradas, Carmen; Pegoraro, Elena; Nadaj-Pakleza, Aleksandra; De Bleecker, Jan; Badrising, Umesh; Alonso-Jiménez, Alicia; Kostera-Pruszczyk, Anna; Miralles, Francesc; Shin, Jin-Hong; Bevilacqua, Jorge Alfredo; Olivé, Montse; Vorgerd, Matthias; Kley, Rudi; Brady, Stefen; Williams, Timothy; Domínguez-González, Cristina; Papadimas, George K; Warman, Jodi; Claeys, Kristl G; de Visser, Marianne; Muelas, Nuria; LaForet, Pascal; Malfatti, Edoardo; Alfano, Lindsay N; Nair, Sruthi S; Manousakis, Georgios; Kushlaf, Hani A; Harms, Matthew B; Nance, Christopher; Ramos-Fransi, Alba; Rodolico, Carmelo; Hewamadduma, Channa; Cetin, Hakan; García-García, Jorge; Pál, Endre; Farrugia, Maria Elena; Lamont, Phillipa J; Quinn, Colin; Nedkova-Hristova, Velina; Peric, Stojan; Luo, Sushan; Oldfors, Anders; Taylor, Kate; Ralston, Stuart; Stojkovic, Tanya; Weihl, Conrad; Diaz-Manera, Jordi (2022. ) Genotype-phenotype correlations in valosin-containing protein disease: a retrospective muticentre study.Journal of neurology, neurosurgery, and psychiatry, , More Information

Kushlaf, Hani (2022. ) The applicability of the myasthenia gravis patient registry data to disease burden and medication changes in clinical practice.Muscle & nerve, , More Information

Kushlaf H. (08-01-2021. ) Update on the Diagnostic and Therapeutic Landscape of Sporadic Inclusion Body Myositis.Current Treatment Options in Neurology, , 23 (8 ) , More Information

Kushlaf H. (12-01-2009. ) Toxic myopathies.Clinical Neurotoxicology: Syndromes, Substances, Environments, , 159-173 More Information

Kushlaf H.A. (06-18-2009. ) Toxic Myopathies.Clinical Neurotoxicology: Syndromes, Substances, Environments, Expert Consult - Online and Print, , 159-173 More Information

Invited Publications

Kushlaf, HA (2013. ) Emerging Toxic Neuropathies and Myopathies .Psychiatr Clin North Am, 36 (2 ) ,209

Other Publications

Kushlaf HA (05-03-2011. ) Hot and Dry foot as a sign of cancer. .E-Pearl of the week,

Kushlaf HA (05-14-2009. ) Cerebral Venous Thrombosis as a cause of thunderclap headache .E-Pearl of the week,

Book Chapter

Kushlaf HA (2009 ) Toxic Myopathies Clinical Neurotoxicology .(pp. 159-174).Elsevier

Presentations

Invited Presentations

Hani A. Kushlaf (10-25-2011. ) Grand Rounds;Peripheral Nerve Ultrasound: From Basics to Clinical Applications .University of Kentucky, Lexington KY.

Hani A. Kushlaf (11-09-2011. ) Seminar;Peripheral Nerve Ultrasound: Is it helpful? .University of Colorado, Aurora, Co.

Hani A. Kushlaf (04-06-2012. ) Grand Rounds; Peripheral Nerve Ultrasound: The Basics and Beyond .Medical Colleage of Wisconsin, Milwaukee, WI.

Poster Presentations

Jonas Vanags, Hani Kushlaf, Vern Juel (02-17-2012. ) Post-irradiation hypoglossal and accessory neuropathies with myokymic discharges .North Carolina Neurological society annual meeting, Greensboro, North Carolina. . Professional Meeting. .

Hani Kushlaf, Vern Juel, Lisa Hobson-Webb (10-03-2012. ) SONOGRAPHICALLY-MEASURED NERVE SIZE AND INTRA-NERVE SIZE VARIABILITY IN INFLAMMATORY POLYNEUEROPATHY .AANEM annual meeting, Orlando, FL. .

Hani Kushlaf, Vern Juel, Lisa Hobson-Webb (10-03-2012. ) DO ULTRASOUND CHARACTERISTICS CORRELATE WITH ELECTRODIAGNOSTIC FINDINGS IN INFLAMMATORY NEUROPATHIES? .AANEM annual meeting, Orlando, FL. .

Hani Kushlaf, Vern Juel, Lisa Hobson-Webb (03-18-2013. ) UPPER EXTREMITY PERIPHERAL NERVE ULTRASOUND SHOWS PROXIMAL TO DISTAL TAPERING OF NERVES IN DEMYELINATING CHARCOT-MARIE-TOOTH DISEASE BUT NOT IN INFLAMMATORY DEMYELINATING NEUROPATHIES .American Academy of Neurology Annual Meeting, San Diego, CA. .

Honors and Awards

05-05-2002 Graduated Summa Cum Laude from Tripoli University, School of Medicine, Tripoli, Libya

2008 -2009 Chief Resident, University of Kentucky , Lexington KY

09-01-2008 Resident of the month award, University of Kentucky, Lexington KY

10-04-2012 Junior Member Recognition Award at the annual AANEM meeting, Orlando, FL

09-2022 AANEM President's Research Initiative Award Status:Recipient Level:National

Professional Affiliation

Fellow American Association of neuromuscular and electrodiagnostic medicine.

Fellow American Academy of Neurology

Fellow American Neurological Association

Contact Information

Practice - University of Cincinnati Gardner Neuroscience Institute
3113 Bellevue Ave.
Cincinnati  Ohio, 45219
Phone: 513-475-8730

Academic - Stetson Building
Cincinnati  Ohio, 45219
Phone: 513-558-1753
hani.kushlaf@uc.edu