George Douglas Leikauf , PhD

AB: University of California, Berkeley Berkeley, CA, 1973 (Biological Sciences)

MS: New York University New York, NY, 1978 (Environmental Health Sciences)

Graduate Fellowship: New York University New York, NY, 1981 (Environmental Health Sciences)

PhD: New York University New York, NY, 1981 (Environmental Health Sciences)

The goals of my research are as follows: to better understand the role of airway epithelium in irritant induced bronchial hyperresponsiveness; to examine the release of specific lipid mediators from epithelial cells following exposure to ozone; to examine the effects of low molecular weight aldehydes on pulmonary function;to measure the expression of genes encoding for key enzymes controlling theproduction of such mediators and the infiltration of cells during nonimmunologic airway hyperreactivity; to examine the secretory physiology of epithelial cells. Currently, examining the regulation of chloride secretion by endogenous arachidonic acid metabolism and release of intracellular calcium. More recently we have begun to study the genetic determinants ofcomplex lung diseases including acute lung injury, asthma, bronchitis, emphysema (or chronic obstructive pulmonary disease) in inbred mice using microstatelite markers and genome wide scans. We are also using cDNA microarray to examine the transcriptosome following inhaltion exposure to acrolein, a component of cigarette smoke, nickel and ozone.

Grant: #1 U01 ES015675-01 Investigators:Leikauf, George 09-29-2006 -05-31-2011 National Institute of Environmental Health Sciences Functional Genomics of Chemical-Induced Acute Lung Injury Role:PI $772,238.00 Closed Level:Federal

Grant: #1-R01-HL-077763-01-A1-S0-E0 Investigators:Leikauf, George 12-15-2005 -11-30-2009 National Heart, Lung and Blood Institute Growth Factor Protection in Acute Lung Injury Role:PI $707,360.00 Closed Level:Federal

Grant: #5-R01-AI-046556-04-A0-S0-E0 Investigators:Leikauf, George 09-30-2001 -06-30-2005 National Institute of Allergy and Infectious Diseases Genetic Determinants of RSV Infection in Mice Role:PI $62,057.00 Closed Level:Federal

Grant: #5-R01-HL-65612-05-A0-S0-E0 Investigators:Leikauf, George 07-01-2000 -06-30-2006 National Heart, Lung and Blood Institute Genetic Determination of Acute Lung Injury Role:PI $1,499,088.63 Closed Level:Federal

Grant: #5-R01-ES-10562-05-A0-S0-E0 Investigators:Leikauf, George 09-21-2001 -06-30-2007 National Institute of Environmental Health Sciences Genetic Determinants of Nickel-Induced Lung Injury Role:PI $1,488,950.22 Closed Level:Federal

Grant: #5-T35-ES-07291-05-A0-S0-E0 Investigators:Leikauf, George 04-01-1995 -03-31-2000 National Institute of Environmental Health Sciences Short-Term Research Training for Minority Students Role:PI $75,442.00 Closed Level:Federal

Grant: #5-R01-HL-58275-03-A0-S0-E0 Investigators:Leikauf, George 09-01-1996 -08-31-2000 National Heart, Lung and Blood Institute Surfactant Deficiency and Air Pollution Susceptibility Role:PI $646,946.00 Closed Level:Federal

Grant: #HEI-98-17-01-A0-S0-E0 Investigators:Leikauf, George 08-01-1998 -09-30-2000 Health Effects Institute Pathogenic Mechanisms of Particulate Matter Role:PI $472,039.00 Closed Level:Private Non-Profit

Grant: #5-R01-HL-65213-03-A0-S0-E0 Investigators:Leikauf, George 09-30-1999 -08-31-2003 National Heart, Lung and Blood Institute Murine Models of Occupational Chronic Obstructive Pulmonary Disease (COPD) Role:PI $786,869.00 Closed Level:Federal

Grant: #UPitt AWD00006524 (138695-1)/ 1R56HL156898-01A1 Investigators:Leikauf, George 09-19-2022 -08-31-2023 National Heart, Lung and Blood Institute Cellular and molecular mechanisms of e-cigarette vaping-induced acute lung injury Role:PI 307688.00 Hold Level:Federal

Grant: #R01ES034490 Investigators:Leikauf, George; Medvedovic, Mario; Shi, Wei 08-20-2023 -07-31-2026 National Institute of Environmental Health Sciences Pathoplysicologic mechansims of e-cigarette-induced chronic obstructive pulmonary disease Role:PI 1467044.00 Awarded Level:Federal

Grant: #P20ES036792 Investigators:Leikauf, George; Morrow, Ardythe 06-01-2024 -05-31-2027 National Institute of Environmental Health Sciences Cincinnati Climate Change and Health Research Center Role:Collaborator 331767.77 Hold Level:Federal

Pharmacokinetics(MeSH PhrmKin),Respiratory System(MeSH A04),Viruses(MeSH B04),Respiratory Tract Diseases(MeSH C08),Organic Chemicals(MeSH D02),Environmental Pollutants, Noxae, and Pesticides(MeSH D05),Enzymes, Coenzymes, and Enzyme Inhibitors(MeSH D08),Growth Substances, Pigments, and Vitamins(MeSH D11),Anti-Inflammatory Agents, Antirheumatic Agents, and Inflammation Mediators(MeSH D17),Environment and Public Health(MeSH G03),Genetic Processes(MeSH G05),Physiological Processes(MeSH G07),Natural Sciences(MeSH H01)

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Phone: 513-558-5701