Alex Lentsch

Alex B Lentsch , PhD

Senior Associate Dean

of Faculty Affairs & Development; Acting Chair of the Department of Environmental and Public Health Sciences; Vice Chair for Research and Director, Division of Research, Department of Surgery; Professor of Surgery

CARE/Crawley Building
Room E870
3235 Eden Avenue
Cincinnati, Ohio 45267
Phone 513-558-0175
Fax 513-558-3513
Email alex.lentsch@uc.edu

Education

Bachelor's Degree: Northern Kentucky University 1991 (Biological Sciences)

Doctoral Degree: University of Louisville 1996 (Physiology and Biophysics)

Research and Practice Interests

Inflammation, Liver Injury, Trauma, Military Medicine

Research Support

Grant: #R01 DK56029 Investigators:Lentsch, AB 09-30-2000 -08-31-2009 NIH/NIDDK Regulation of hepatic ischemia/reperfusion injury Role:Principal Investigator Type:Grant

Grant: #R01 AG025881 Investigators:Lentsch, AB 06-01-2005 -05-31-2010 NIH/NIA Age effects on inflammation and injury Role:Principal Investigator Type:Grant

Grant: #R01 GM072760 Investigators:Caldwell, CC 09-01-2005 -08-31-2010 NIH/NIGMS Role of HIF-1alpha in T cells during sepsis Role:Co-Investigator Type:Grant

Grant: #R01 DK055030 Investigators:Schuschke, DA 07-01-2007 -03-31-2009 NIH/NIDDK Leukocyte adhesion in copper-deficient microcirculation Role:Co-Investigator Type:Grant

Grant: #T32 GM08478 Investigators:Solomkin, JS 07-01-2008 -06-30-2013 NIH/NIGMS Host response to trauma research training program Role:Co-Program Director Type:Grant

Grant: #K02-HL-072552 Investigators:Lentsch, Alex 07-01-2002 -06-30-2007 National Heart, Lung and Blood Institute Hepatic Ischemia/Reperfusion-Induced Lung Injury Role:PI $536,220.00 Closed Level:Federal

Grant: #R01-DK-56029 Investigators:Lentsch, Alex 09-30-2004 -08-31-2009 National Inst of Diabetes and Digestive and Kidney Disease Regulation of Hepatic Ischemia/Reperfusion Injury Role:PI $1,705,844.00 Closed Level:Federal

Grant: #5-R01-AG-025881-02-A0-S0-E0 Investigators:Lentsch, Alex 06-01-2005 -07-31-2010 National Institute on Aging Age Effects on Liver Inflammation and Injury Role:PI $1,468,415.00 Closed Level:Federal

Investigators:Lentsch, Alex 08-01-2002 -07-31-2005 Department of the Army Chemokines and Prostate Tumor Growth Role:PI $313,998.00 Closed Level:Federal

Grant: #5-R01-DK-56029-05-A0-S0-E0 Investigators:Lentsch, Alex 05-01-2002 -09-29-2004 National Inst of Diabetes and Digestive and Kidney Disease Regulation of Hepatic Ischemia/Reperfusion Injury Role:PI $454,608.00 Closed Level:Federal

Grant: #OGMB040896 / NIH 5R01D055030-07 Investigators:Lentsch, Alex 07-01-2007 -03-31-2009 National Inst of Diabetes and Digestive and Kidney Disease Leukocyte Adhesion in Copper Deficient Microcirculation Role:PI $55,067.00 Active Level:Federal

Grant: #2008 Agreements Investigators:Lentsch, Alex 01-01-2008 -12-31-2008 Shriners Hospitals for Children - Cincinnati Shriners - Surgery Consulting Requisitions 2008 Role:PI $992,919.60 Active Level:Private Non-Profit

Grant: #T32 GM008478 Investigators:Lentsch, Alex 07-01-2008 -06-30-2013 National Institute of General Medical Sciences Host Response to Trauma Research Training Program Role:PI $1,156,018.00 Active Level:Federal

Grant: #611-243-11SAM-00-104583 / FA8650-05-2-6518 Investigators:Barnes, Stephen; Dorlac, Warren; Lentsch, Alex 06-01-2008 -08-31-2010 Department of the Army Medical Research and Materiel Command Strategic Aeromedical Evacuation Effects On Very Severely Injured (VSI) Casualties Role:PI $1,479,650.00 Active Level:Federal

Grant: #R01 CA125379 Investigators:Collins, Margaret; Ho, Shuk Mei; Knudsen, Karen; Lentsch, Alex; Waltz, Susan 09-01-2008 -07-31-2014 National Cancer Institute The Ron Receptor/Chemokine Axis in Prostate Cancer Role:Collaborator $1,275,379.00 Active Level:Federal

Grant: #2009 Agreements Investigators:Lentsch, Alex 01-01-2009 -12-31-2009 Shriners Hospitals for Children - Cincinnati Shriners - Surgery Consulting Requisitions 2009 Role:PI $937,527.00 Closed Level:Private Non-Profit

Grant: #USAF-CRADA Investigators:Lentsch, Alex 04-07-2009 -04-06-2014 United States Air Force Academy Coopertive Research and Development Agreement: Cadet Summer Research Program Role:PI $.00 Active Level:Federal

Grant: #2 R01 DK056029-11A1 Investigators:Edwards, Michael; Lentsch, Alex 09-01-2009 -08-31-2014 National Inst of Diabetes and Digestive and Kidney Disease Chemokine Regulation of Liver Injury and Recovery Role:PI $1,742,158.00 Active Level:Federal

Grant: #FA7014-09-2-0006 Investigators:Athota, Krishna; Dorlac, Warren; Johannigman, Jay; Lentsch, Alex 09-30-2009 -09-29-2013 Department of the Air Force Effect of Omega-3 Fatty Acid Supplementation of Infection Rate and Morbidity in Multisystem Trauma Patients Role:Collaborator $654,960.00 Active Level:Federal

Grant: #FA7014-09-2-0005 (WOUND) Investigators:Dorlac, Warren; Johannigman, Jay; Lentsch, Alex; Pritts, Timothy 09-30-2009 -09-29-2011 Department of the Air Force Effect of Altitude on Wound Infection and Changes Seen After Treatment with Supplemental Oxygen and Negative Pressure Wound Therapy Role:PI $900,000.00 Active Level:Federal

Grant: #W81XWH-09-1-0625 Investigators:Caldwell, Charles; Lentsch, Alex 09-03-2009 -09-02-2012 Department of the Army Medical Research Acquisition Activity Effects of Different Fluid Resuscitation Strategies on Systemic Inflammation, Immunocompromise, Organ Dysfunction and Death Role:PI $708,840.00 Closed Level:Federal

Grant: #SRS 006688 Investigators:Lentsch, Alex 01-01-2010 -12-31-2010 Shriners Hospitals for Children - Cincinnati Shriners - Surgery Consulting Requisitions 2010 Role:PI $346,842.00 Closed Level:Private Non-Profit

Grant: #R01 AG025881 Investigators:Lentsch, Alex 08-01-2010 -05-31-2015 National Institute on Aging Age Effects on Liver Inflammation and Injury Role:PI $1,205,644.00 Active Level:Federal

Grant: #CSTARS Co-op Master Agreement Investigators:Lentsch, Alex 08-01-2010 -07-31-2015 Department of the Air Force Expeditionary Medicine, Trauma, and Enroute CARE (EMTEC) Research and Technology Support - Basic Agreement Role:PI $.00 Active Level:Federal

Grant: #SHRINERS 2011 Investigators:Lentsch, Alex 01-01-2011 -12-31-2011 Shriners Hospitals for Children - Cincinnati Shriners - Surgery Consulting Requisitions 2010 Role:PI $328,571.33 Closed Level:Private Non-Profit

Grant: #FA8650-10-2-6B01 Task 1 Investigators:Lentsch, Alex 08-11-2010 -08-10-2013 Air Force Research Laboratory Expeditionary Medicine, Trauma, and Enroute CARE (EMTEC) Research and Technology Support - Basic Agreement Role:PI $1,978,172.00 Active Level:Federal

Grant: #FA8650-11-2-6B05 Task 5 Investigators:Branson, Richard; Caldwell, Charles; Johannigman, Jay; Lentsch, Alex; Pritts, Timothy 11-23-2010 -11-22-2012 Air Force Research Laboratory Determining the Oxygen Requirements Using an Oxygen Concentrator at Altitude Role:Collaborator $776,561.00 Active Level:Federal

Grant: #Shriners 2012 Investigators:Lentsch, Alex 01-01-2012 -12-31-2012 Shriners Hospitals for Children - Cincinnati Shrine 2012 Surgery Role:PI $367,530.96 Active Level:Private Non-Profit

Grant: #FA8650-12-2-6B11 Task 11 Under Master FA8650-10-2-6140 Investigators:Branson, Richard; Dorlac, Warren; Hinckley, William; Johannigman, Jay; Lentsch, Alex; Lindsell, Christopher; McMullan, Jason; Meunier, Jason; Robinson, Bryce 05-08-2012 -05-07-2015 Department of the Air Force Closed Loop Control of Mechanical Ventilation, FA8650-12-2-6B11 Role:Collaborator $503,000.00 Active Level:Federal

Grant: #FA8650-12-2-6B10 Task order 10 Investigators:Branson, Richard; Dorlac, Warren; Johannigman, Jay; Lentsch, Alex; Robinson, Bryce 05-09-2012 -05-08-2015 Department of the Air Force Closed Loop Control of Oxygen Delivery and Oxygen Generation, FA8650-12-2-6B10 Role:Collaborator $674,000.00 Active Level:Federal

Grant: #2013 Consultant Requisition Investigators:Lentsch, Alex 01-01-2013 -12-31-2013 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2013 Role:PI $347,840.54 Awarded Level:Private Non-Profit

Grant: #T32GM008478 Investigators:Lentsch, Alex 07-01-2013 -06-30-2018 National Institute of General Medical Sciences Host Response to Trauma Research Training Program Role:PI $181,925.00 Awarded Level:Federal

Grant: #132581 \ R21AA020846 Investigators:Lentsch, Alex 05-08-2013 -01-31-2014 National Institute on Alcohol Abuse and Alcoholism Mechanisms of Alcoholic Liver Disease Role:PI $31,777.00 Active Level:Federal

Grant: #R01 GM107625 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 02-01-2014 -12-31-2018 National Institute of General Medical Sciences Red blood cell microparticles and lung inflammation after hemorrhage and resuscit Role:Collaborator $313,038.00 Awarded Level:Federal

Grant: #FA8650-14-2-6B20 under Master FA8650-10-2-6140 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 05-23-2014 -05-22-2015 Air Force Research Laboratory Effect of pRBC Cryopreservation on Development of the Storage Lesion and Inflammation Role:Collaborator $247,143.00 Active Level:Federal

Grant: #FA8650-14-2-6B25 / Task under Master FA8650-10-2-6140 Investigators:Lentsch, Alex 06-18-2014 -06-17-2015 Air Force Research Laboratory Evaluation of Mouse Wound Models for Probiotic-Based Wound Infection Prevention Studies Role:PI $242,020.00 Awarded Level:Federal

Grant: #SHRINE 2014 Investigators:Lentsch, Alex 01-01-2014 -12-31-2014 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2014 Role:PI $350,968.00 Awarded Level:Private Non-Profit

Grant: #FA8650-14-2-6B33 (Task 33 under Master FA8650-10-2-6140) Investigators:Lentsch, Alex; Robinson, Bryce 09-11-2014 -09-10-2015 Air Force Research Laboratory Reducing biofilm and ventilator associated pneumonia using sphingosine Role:Collaborator $252,210.00 Awarded Level:Federal

Grant: #R01 DK056029 Investigators:Lentsch, Alex 07-01-2015 -06-30-2019 National Inst of Diabetes and Digestive and Kidney Disease Chemokine/exosome axis and liver repair after ischemia/reperfusion Role:PI $430,057.00 Awarded Level:Federal

Grant: #SHRINE 2015 Investigators:Lentsch, Alex 01-01-2015 -12-31-2015 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2015 Role:PI $400,179.00 Active Level:Private Non-Profit

Grant: #FA8650-15-2-6B35 / Task under Master FA8650-10-2-6140 Investigators:Athota, Krishna; Lentsch, Alex; Makley, Amy; Pritts, Timothy 07-15-2015 -01-14-2017 Air Force Research Laboratory Comparison of Combat Gauze with Fibrin Sealant Patch in Hemorrhage Control after Vascular or Hepatic Trauma Role:Collaborator $231,000.00 Awarded Level:Federal

Grant: #CSTARS Co-op EMTEC Master Agreement Investigators:Lentsch, Alex 09-29-2015 -09-28-2021 Air Force Research Laboratory Expeditionary Medicine, Trauma, and Enroute Care (EMTEC) Research and Technology Development Co-op Agreement Role:PI $.00 Active Level:Federal

Grant: #2016 Shriner's Investigators:Lentsch, Alex 01-01-2016 -12-31-2016 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2016 Role:PI $468,237.20 Awarded Level:Private Non-Profit

Grant: #FA8650-16-2-6G05 (Task under Master FA8650-15-2-6605) Investigators:Caldwell, Charles; Goodman, Michael; Lentsch, Alex; Makley, Amy; Pritts, Timothy; Robinson, Bryce 02-26-2016 -02-25-2019 Air Force Research Laboratory Effect of fluid resuscitation strategy during en route care on acute lung injury after hemorrhage and burn injury. Role:Collaborator $396,000.00 Awarded Level:Federal

Grant: #135658 / W81XWH-15-1-0370 Investigators:Lentsch, Alex; Wang, Jiang 09-30-2015 -09-29-2018 Department of the Army Medical Research Acquisition Activity Mechanisms of nonalcoholic steatohepatitis Role:Collaborator $3,600.00 Awarded Level:Federal

Grant: #DoD1-SA1 / W81XWH-15-2-0065 Investigators:Babcock, George; Lentsch, Alex 01-01-2017 -12-31-2017 Department of the Army Medical Research Acquisition Activity Antimicrobial block copolypeptides (A-Blocks): Innovative Therapeutics and Prophylacics for Wound Infection Role:Collaborator $517,802.00 Awarded Level:Federal

Grant: #Shriner's 2017 Investigators:Lentsch, Alex 01-01-2017 -12-31-2017 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2017 Role:PI $766,576.00 Awarded Level:Private Non-Profit

Grant: #FA8650-17-2-6G23 (Task under Master FA8650-15-2-6605) Investigators:Edwards, Michael; Gulbins, Erich; Johannigman, Jay; Lentsch, Alex 03-30-2017 -03-29-2019 Air Force Research Laboratory Role of Sphingosine Coated Endotracheal Tubes (ETT) in Preventing Endotracheal Biofilm Role:Collaborator $231,000.00 Awarded Level:Federal

Grant: #Shriner's 2018 Investigators:Lentsch, Alex 01-01-2018 -12-31-2018 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2018 Role:PI $808,593.00 Awarded Level:Private Non-Profit

Grant: #T32GM008478 Investigators:Lentsch, Alex 07-01-2018 -06-30-2023 National Institute of General Medical Sciences Host Response to Trauma Research Training Program Role:PI $274,769.00 Active Level:Federal

Grant: #Shriner 2019 Investigators:Lentsch, Alex 01-01-2019 -12-31-2019 Shriners Hospitals for Children - Cincinnati Shriner's Hospital Consulting Agreements, calendar year 2019 Role:PI $412,172.72 Awarded Level:Private Non-Profit

Grant: #R01 GM107625-06A1 Investigators:Caldwell, Charles; Gulbins, Erich; Lentsch, Alex; Pritts, Timothy 02-01-2014 -03-31-2023 National Institutes of Health Red blood cell microparticles and lung inflammation after hemorrhage and resuscitation Role:Collaborator $352,825.00 Awarded Level:Federal

Grant: #HL099010 Investigators:Lentsch, Alex; Pritts, Timothy 08-01-2013 -07-31-2016 National Heart, Lung and Blood Institute Keratin Biomaterial-bases Fluid for Trauma Resuscitation Role:Collaborator $190,000.00 Closed Level:Federal

Grant: #FA8650-21-2-6285 Investigators:Blakeman, Thomas; Branson, Richard; Caldwell, Charles; Gomaa, Dina; Goodman, Michael; Lentsch, Alex; McMullan, Jason; Pritts, Timothy 09-30-2021 -09-29-2027 Air Force Research Laboratory Expeditionary Medicine, Trauma, and Enroute Care (EMTEC) Research and Technology Development Co-op Agreement Role:PI 49000000.00 Hold Level:Federal

Publications

Peer Reviewed Publications

Solomkin,J.S.; Robinson,C.T.; Cave,C.M.; Ehmer,B.; Lentsch,A.B. (2007. ) Alterations in membrane cholesterol cause mobilization of lipid rafts from specific granules and prime human neutrophils for enhanced adherence-dependent oxidant production .Shock, , 28 (3 ) ,334 -338

Saari,J.T.; Wold,L.E.; Duan,J.; Ren,J.; Carlson,H.L.; Bode,A.M.; Lentsch,A.B.; Zeng,H.; Schuschke,D.A. (2007. ) Cardiac nitric oxide synthases are elevated in dietary copper deficiency .Journal of Nutritional Biochemistry, , 18 (7 ) ,443 -448

Kuboki,S.; Okaya,T.; Schuster,R.; Blanchard,J.; Denenberg,A.; Wong,H.R.; Lentsch,A.B. (2007. ) Hepatocyte nf-κb activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 292 (1 ) ,G201 -G207

Caldwell,C.C.; Tschoep,J.; Lentsch,A.B. (2007. ) Lymphocyte function during hepatic ischemia/reperfusion injury .Journal of Leukocyte Biology, , 82 (3 ) ,457 -464

Kuboki,S.; Schuster,R.; Blanchard,J.; Pritts,T.A.; Wong,H.R.; Lentsch,A.B. (2007. ) Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 292 (4 ) ,G1141 -G1149

Lentsch,A.B.; Pathrose,P.; Kader,S.; Kuboki,S.; Collins,M.H.; Waltz,S.E. (2007. ) The ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor κb activation .Shock, , 27 (3 ) ,274 -280

Shen,H.; Schuster,R.; Lu,B.; Waltz,S.E.; Lentsch,A.B. (2006. ) Critical and opposing roles of the chemokine receptors cxcr2 and cxcr3 in prostate tumor growth .Prostate, , 66 (16 ) ,1721 -1728

Lentsch,A.B. (2006. ) Cxc chemokines and prostate cancer: growth regulators and potential biomarkers .Future Oncology, , 2 (5 ) ,651 -658

Solomkin,J.S.; Robinson,C.T.; Cave,C.M.; Umanskiy,K.; Matlin,K.; Williams,M.A.; Lentsch,A.B. (2006. ) Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space .Shock, , 25 (5 ) ,440 -445

Mallakin,A.; Kutcher,L.W.; McDowell,S.A.; Kong,S.; Schuster,R.; Lentsch,A.B.; Aronow,B.J.; Leikauf,G.D.; Waltz,S.E. (2006. ) Gene expression profiles of mst1r-deficient mice during nickel-induced acute lung injury .American Journal of Respiratory Cell and Molecular Biology, , 34 (1 ) ,15 -27

Husted,T.L.; Blanchard,J.; Schuster,R.; Shen,H.; Lentsch,A.B. (2006. ) Potential role for il-23 in hepatic ischemia/reperfusion injury .Inflammation Research, , 55 (5 ) ,177 -178

Toledo-Pereyra,L.H.; Lopez-Neblina,F.; Lentsch,A.B.; Anaya-Prado,R.; Romano,S.J.; Ward,P.A. (2006. ) Selectin inhibition modulates nf-κb and ap-1 signaling after liver ischemia/reperfusion .Journal of Investigative Surgery, , 19 (5 ) ,313 -322

Shen,H.; Schuster,R.; Stringer,K.F.; Waltz,S.E.; Lentsch,A.B. (2006. ) The duffy antigen/receptor for chemokines (darc) regulates prostate tumor growth .FASEB Journal, , 20 (1 ) ,59 -64

Husted,T.L.; Lentsch,A.B. (2006. ) The role of cytokines in pharmacological modulation of hepatic ischemia/reperfusion injury .Current Pharmaceutical Design, , 12 (23 ) ,2867 -2873

Husted,T.L.; Govindaswami,M.; Oeltgen,P.R.; Rudich,S.M.; Lentsch,A.B. (2005. ) A δ2-opioid agonist inhibits p38 mapk and suppresses activation of murine macrophages .Journal of Surgical Research, , 128 (1 ) ,45 -49

Okaya,T.; Blanchard,J.; Schuster,R.; Kuboki,S.; Husted,T.; Caldwell,C.C.; Zingarelli,B.; Wong,H.; Solomkin,J.S.; Lentsch,A.B. (2005. ) Age-dependent responses to hepatic ischemia/reperfusion injury .Shock, , 24 (5 ) ,421 -427

Husted,T.L.; Lentsch,A.B. (2005. ) Anti-inflammatory approaches to the prevention of ischemia/reperfusion injury in solid organ transplantation .Current Opinion in Investigational Drugs, , 6 (5 ) ,508 -512

Barone,S.; Okaya,T.; Rudich,S.; Petrovic,S.; Tenrani,K.; Wang,Z.; Zahedi,K.; Casero,R.A.; Lentsch,A.B.; Soleimani,M. (2005. ) Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury .American Journal of Physiology - Cell Physiology, , 289 (4 58-4 ) ,C826 -C835

Caldwell,C.C.; Okaya,T.; Martignoni,A.; Husted,T.; Schuster,R.; Lentsch,A.B. (2005. ) Divergent functions of cd4+ t lymphocytes in acute liver inflammation and injury after ischemia-reperfusion .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 289 (5 52-5 ) ,G969 -G976

Okaya,T.; Lentsch,A.B. (2005. ) Hepatic expression of s32a/s36a iκbα does not reduce postischemic liver injury .Journal of Surgical Research, , 124 (2 ) ,244 -249

Thakar,C.V.; Zahedi,K.; Revelo,M.P.; Wang,Z.; Burnham,C.E.; Barone,S.; Bevans,S.; Lentsch,A.B.; Rabb,H.; Soleimani,M. (2005. ) Identification of thrombospondin 1 (tsp-1) as a novel mediator of cell injury in kidney ischemia .Journal of Clinical Investigation, , 115 (12 ) ,3451 -3459

Gordon,S.A.; Lominadze,D.; Saari,J.T.; Lentsch,A.B.; Schuschke,D.A. (2005. ) Impaired deformability of copper-deficient neutrophils .Experimental Biology and Medicine, , 230 (8 ) ,543 -548

Williams,M.A.; Cave,C.M.; Quaid,G.; Robinson,C.; Daly,T.J.; Witt,D.; Lentsch,A.B.; Solomkin,J.S. (2005. ) Interleukin 8 dimerization as a mechanism for regulation of neutrophil adherence-dependent oxidant production .Shock, , 23 (4 ) ,371 -376

Mayhew,C.N.; Bosco,E.E.; Fox,S.R.; Okaya,T.; Tarapore,P.; Schwemberger,S.J.; Babcock,G.F.; Lentsch,A.B.; Fukasawa,K.; Knudsen,E.S. (2005. ) Liver-specific prb loss results in ectopic cell cycle entry and aberrant ploidy .Cancer Research, , 65 (11 ) ,4568 -4577

Okaya,T.; Holthaus,R.; Kato,A.; Lentsch,A.B. (2004. ) Involvement of the neuropeptide substance p in lung inflammation induced by hepatic ischemia/reperfusion .Inflammation Research, , 53 (6 ) ,257 -261

Okaya,T.; Lentsch,A.B. (2004. ) Peroxisome proliferator-activated receptor-α regulates postischemic liver injury .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 286 (4 49-4 ) ,G606 -G612

Shen,H.; Lentsch,A.B. (2004. ) Progressive dysregulation of transcription factors nf-κb and stat1 in prostate cancer cells causes proangiogenic production of cxc chemokines .American Journal of Physiology - Cell Physiology, , 286 (4 55-4 ) ,C840 -C847

Okaya,T.; Lentsch,A.B. (2003. ) Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion .Journal of Investigative Surgery, , 16 (3 ) ,141 -147

Kato,A.; Okaya,T.; Lentsch,A.B. (2003. ) Endogenous il-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury .Hepatology, , 37 (2 ) ,304 -312

Umanskiy,K.; Robinson,C.; Cave,C.; Williams,M.A.; Lentsch,A.B.; Cuschieri,J.; Solomkin,J.S. (2003. ) Nadph oxidase activation in fibronectin adherent human neutrophils: a potential role for β1 integrin ligation .Surgery, , 134 (2 ) ,378 -383

Guo,R.-F.; Lentsch,A.B.; Sarma,J.V.; Sun,L.; Riedemann,N.C.; McClintock,S.D.; McGuire,S.R.; Van Rooijen,N.; Ward,P.A. (2002. ) Activator protein-1 activation in acute lung injury .American Journal of Pathology, , 161 (1 ) ,275 -282

Ward,P.A.; Lentsch,A.B. (2002. ) Endogenous regulation of the acute inflammatory response .Molecular and Cellular Biochemistry, , 234-235 ,225 -228

Kato,A.; Edwards,M.J.; Lentsch,A.B. (2002. ) Gene deletion of nf-κb p50 does not alter the hepatic inflammatory response to ischemia/reperfusion .Journal of Hepatology, , 37 (1 ) ,48 -55

Anaya-Prado,R.; Toledo-Pereyra,L.H.; Lentsch,A.B.; Ward,P.A. (2002. ) Ischemia/reperfusion injury .Journal of Surgical Research, , 105 (2 ) ,248 -258

Kato,A.; Singh,S.; McLeish,K.R.; Edwards,M.J.; Lentsch,A.B. (2002. ) Mechanisms of hypothermic protection against ischemic liver injury in mice .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 282 (4 45-4 ) ,G608 -G616

Kato,A.; Graul-Layman,A.; Edwards,M.J.; Lentsch,A.B. (2002. ) Promotion of hepatic ischemia/reperfusion injury by il-12 is independent of stat4 .Transplantation, , 73 (7 ) ,1142 -1145

Kato,A.; Gabay,C.; Okaya,T.; Lentsch,A.B. (2002. ) Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion .American Journal of Pathology, , 161 (5 ) ,1797 -1803

Lentsch,A.B. (2002. ) The duffy antigen/receptor for chemokines (darc) and prostate cancer. a role as clear as black and white? .FASEB Journal, , 16 (9 ) ,1093 -1095

Schuschke,D.A.; Percival,S.S.; Lominadze,D.; Saari,J.T.; Lentsch,A.B. (2002. ) Tissue-specific icam-1 expression and neutrophil transmigration in the copper-deficient rat .Inflammation, , 26 (6 ) ,297 -303

Lentsch,A.B.; Kato,A.; Saari,J.T.; Schuschke,D.A. (2001. ) Augmented metalloproteinase activity and acute lung injury in copper-deficient rats .American Journal of Physiology - Lung Cellular and Molecular Physiology, , 281 (2 25-2 ) ,L387 -L393

Lentsch,A.B.; Ward,P.A. (2001. ) Regulation of experimental lung inflammation .Respiration Physiology, , 128 (1 ) ,17 -22

Guo,R.-F.; Lentsch,A.B.; Warner,R.L.; Huber-Lang,M.; Sarma,J.V.; Hlaing,T.; Shi,M.M.; Lukacs,N.W.; Ward,P.A. (2001. ) Regulatory effects of eotaxin on acute lung inflammatory injury .Journal of Immunology, , 166 (8 ) ,5208 -5218

Lentsch,A.B.; Kato,A.; Davis,B.; Wang,W.; Chao,C.; Edwards,M.J. (2001. ) Stat4 and stat6 regulate systemic inflammation and protect against lethal endotoxemia .Journal of Clinical Investigation, , 108 (10 ) ,1475 -1482

Godshall,C.J.; Lentsch,A.B.; Peyton,J.C.; Scott,M.J.; Cheadle,W.G. (2001. ) Stat4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis .Clinical and Diagnostic Laboratory Immunology, , 8 (6 ) ,1044 -1048

Mulligan,M.S.; Lentsch,A.B.; Huber-Lang,M.; Guo,R.-F.; Sarma,V.; Wright,C.D.; Ulich,T.R.; Ward,P.A. (2000. ) Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor .American Journal of Pathology, , 156 (3 ) ,1033 -1039

Dawson,T.C.; Lentsch,A.B.; Wang,Z.; Cowhig,J.E.; Rot,A.; Maeda,N.; Peiper,S.C. (2000. ) Exaggerated response to endotoxin in mice lacking the duffy antigen/receptor for chemokines (darc) .Blood, , 96 (5 ) ,1681 -1684

Lentsch,A.B.; Kato,A.; Yoshidome,H.; McMasters,K.M.; Edwards,M.J. (2000. ) Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury .Hepatology, , 32 (2 ) ,169 -173

Yoshidome,H.; Miyazaki,M.; Shimizu,H.; Ito,H.; Nakagawa,K.; Ambiru,S.; Nakajima,N.; Edwards,M.J.; Lentsch,A.B. (2000. ) Obstructive jaundice impairs hepatic sinusoidal endothelial cell function and renders liver susceptible to hepatic ischemia/reperfusion .Journal of Hepatology, , 33 (1 ) ,59 -67

Kato,A.; Yoshidome,H.; Edwards,M.J.; Lentsch,A.B. (2000. ) Reduced hepatic ischemia/reperfusion injury by il-4: potential anti- inflammatory role of stat6 .Inflammation Research, , 49 (6 ) ,275 -279

Lentsch,A.B. (2000. ) Regulation of acute inflammation by the duffy antigen/ receptor for chemokines (darc): exaggerated response to lps in knockout mice and protection in transgenic mice programmed for endothelial expression .Blood, , 96 (11 PART I ) ,

Lentsch,A.B.; Ward,P.A. (2000. ) Regulation of inflammatory vascular damage .Journal of Pathology, , 190 (3 ) ,343 -348

Kato,A.; Yoshidome,H.; Edwards,M.J.; Lentsch,A.B. (2000. ) Regulation of liver inflammatory injury by signal transducer and activator of transcription-6 .American Journal of Pathology, , 157 (1 ) ,297 -302

Molestina,R.E.; Miller,R.D.; Lentsch,A.B.; Ramirez,J.A.; Summersgill,J.T. (2000. ) Requirement for nf-κb in transcriptional activation of monocyte chemotactic protein 1 by chlamydia pneumoniae in human endothelial cells .Infection and Immunity, , 68 (7 ) ,4282 -4288

Bless,N.M.; Huber-Lang,M.; Guo,R.-F.; Warner,R.L.; Schmal,H.; Czermak,B.J.; Shanley,T.P.; Crouch,L.D.; Lentsch,A.B.; Sarma,V.; Mulligan,M.S.; Friedl,H.P.; Ward,P.A. (2000. ) Role of cc chemokines (macrophage inflammatory protein-1β, monocyte chemoattractant protein-1, rantes) in acute lung injury in rats .Journal of Immunology, , 164 (5 ) ,2650 -2659

Lentsch,A.B.; Ward,P.A. (2000. ) The nfκb/iκb system in acute inflammation .Archivum Immunologiae et Therapiae Experimentalis, , 48 (2 ) ,59 -63

Lentsch,A.B.; Ward,P.A. (1999. ) Activation and regulation of nfκb during acute inflammation .Clinical Chemistry and Laboratory Medicine, , 37 (3 ) ,205 -208

Yoshidome,H.; Lentsch,A.B.; Cheadle,W.G.; Miller,F.N.; Edwards,M.J. (1999. ) Enhanced pulmonary expression of cxc chemokines during hepatic ischemia/reperfusion-induced lung injury in mice .Journal of Surgical Research, , 81 (1 ) ,33 -37

Lentsch,A.B.; Czermak,B.J.; Bless,N.M.; Van Rooijen,N.; Ward,P.A. (1999. ) Essential role of alveolar macrophages in intrapulmonary activation of nf-κb .American Journal of Respiratory Cell and Molecular Biology, , 20 (4 ) ,692 -698

Yoshidome,H.; Kato,A.; Miyazaki,M.; Edwards,M.J.; Lentsch,A.B. (1999. ) Il-13 activates stat6 and inhibits liver injury induced by ischemia/reperfusion .American Journal of Pathology, , 155 (4 ) ,1059 -1064

Lentsch,A.B.; Jordan,J.A.; Czermak,B.J.; Diehl,K.M.; Younkin,E.M.; Sarma,V.; Ward,P.A. (1999. ) Inhibition of nf-κb activation and augmentation of iκbβ by secretory leukocyte protease inhibitor during lung inflammation .American Journal of Pathology, , 154 (1 ) ,239 -247

Yoshidome,H.; Kato,A.; Edwards,M.J.; Lentsch,A.B. (1999. ) Interleukin-10 inhibits pulmonary nf-κb activation and lung injury induced by hepatic ischemia-reperfusion .American Journal of Physiology - Lung Cellular and Molecular Physiology, , 277 (5 21-5 ) ,L919 -L923

Yoshidome,H.; Kato,A.; Edwards,M.J.; Lentsch,A.B. (1999. ) Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: implications of a central role for nuclear factor κb .Hepatology, , 30 (1 ) ,203 -208

Lentsch,A.B.; Miller,F.N.; Edwards,M.J. (1999. ) Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2 .Cancer Immunology Immunotherapy, , 47 (5 ) ,243 -248

Lentsch,A.B.; Czermak,B.J.; Jordan,J.A.; Ward,P.A. (1999. ) Regulation of acute lung inflammatory injury by endogenous il-13 .Journal of Immunology, , 162 (2 ) ,1071 -1076

Lentsch,A.B.; Crouch,L.D.; Jordan,J.A.; Czermak,B.J.; Yun,E.C.; Renfeng,G.; Sarma,V.; Diehl,K.M.; Ward,P.A. (1999. ) Regulatory effects of interleukin-11 during acute lung inflammatory injury .Journal of Leukocyte Biology, , 66 (1 ) ,151 -157

Lentsch,A.B.; Yoshidome,H.; Kato,A.; Warner,R.L.; Cheadle,W.G.; Ward,P.A.; Edwards,M.J. (1999. ) Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice .Hepatology, , 30 (6 ) ,1448 -1453

Bless,N.M.; Waener,R.L.; Padgaonkar,V.A.; Lentsch,A.B.; Czermak,B.J.; Schmal,H.; Friedl,H.P.; Ward,P.A. (1999. ) Roles for c-x-c chemokines and c5a in lung injury after hindlimb ischemia-reperfusion .American Journal of Physiology - Lung Cellular and Molecular Physiology, , 276 (1 20-1 ) ,L57 -L63

Lentsch,A.B.; Yoshidome,H.; Warner,R.L.; Ward,P.A.; Edwards,M.J. (1999. ) Secretory leukocyte protease inhibitor in mice regulates local and remote organ inflammatory injury induced by hepatic ischemia/reperfusion .Gastroenterology, , 117 (4 ) ,953 -961

Czermak,B.J.; Lentsch,A.B.; Bless,N.M.; Schmal,H.; Friedl,H.P.; Ward,P.A. (1999. ) Synergistic enhancement of chemokine generation and lung injury by c5a or the membrane attack complex of complement .American Journal of Pathology, , 154 (5 ) ,1513 -1524

Ward,P.A.; Lentsch,A.B. (1999. ) The acute inflammatory response and its regulation .Archives of Surgery, , 134 (6 ) ,666 -669

Lentsch,A.B.; Ward,P.A. (1999. ) Understanding the pathogenesis of inflammation using rodent models: identification of a transcription factor (nfκb) necessary for development of inflammatory injury .ILAR Journal, , 40 (4 ) ,151 -156

Lentsch,A.B.; Yoshidome,H.; Cheadle,W.G.; Miller,F.N.; Edwards,M.J. (1998. ) Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and kupffer cells .Hepatology, , 27 (2 ) ,507 -512

Mulligan,M.S.; Lentsch,A.B.; Shanley,T.P.; Miyasaka,M.; Johnson,K.J.; Ward,P.A. (1998. ) Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody .Inflammation, , 22 (4 ) ,403 -417

Mulligan,M.S.; Lentsch,A.B.; Miyasaka,M.; Ward,P.A. (1998. ) Cytokine and adhesion molecule requirements for neutrophil recruitment during glycogen-induced peritonitis .Inflammation Research, , 47 (6 ) ,251 -255

Lentsch,A.B.; Bless,N.M.; Czermak,B.J.; Ward,P.A. (1998. ) Determinants of nf-κb activation in acute lung injury .FASEB Journal, , 12 (5 ) ,

Bless,N.M.; Tojo,S.J.; Kawarai,H.; Natsume,Y.; Lentsch,A.B.; Padgaonkar,V.A.; Czermak,B.J.; Schmal,H.; Friedl,H.P.; Ward,P.A. (1998. ) Differing patterns of p-selectin expression in lung injury .American Journal of Pathology, , 153 (4 ) ,1113 -1122

Mulligan,M.S.; Lentsch,A.B.; Ward,P.A. (1998. ) In vivo recruitment of neutrophils: consistent requirements for l-arginine and variable requirements for complement and adhesion molecules .Inflammation, , 22 (3 ) ,327 -339

Lentsch,A.B.; Czermak,B.J.; Bless,N.M.; Ward,P.A. (1998. ) Nf-κb activation during igg immune complex-induced lung injury: requirements for tnf-α and il-1β but not complement .American Journal of Pathology, , 152 (5 ) ,1327 -1336

Lentsch,A.B.; Edwards,M.J.; Sims,D.E.; Miller,F.N. (1998. ) Nw-nitro-l-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2 .Journal of Leukocyte Biology, , 63 (1 ) ,22 -30

Czermak,B.J.; Lentsch,A.B.; Bless,N.M.; Schmal,H.; Friedl,H.P.; Ward,P.A. (1998. ) Role of complement in in vitro and in vivo lung inflammatory reactions .Journal of Leukocyte Biology, , 64 (1 ) ,40 -48

Schmal,H.; Czermak,B.J.; Lentsch,A.B.; Bless,N.M.; Beck-Schimmer,B.; Friedl,H.P.; Ward,P.A. (1998. ) Soluble icam-1 activates lung macrophages and enhances lung injury .Journal of Immunology, , 161 (7 ) ,3685 -3693

Lentsch,A.B.; Nakagawa,K.; Yoshidome,H.; Gerassimides,A.; Miller,F.N.; Edwards,M.J. (1997. ) Distinct biologisal activities of recombinant forms of human interleukin-2 in vivo .Cancer Immunology Immunotherapy, , 43 (6 ) ,331 -336

Lentsch,A.B.; Shanley,T.P.; Sarma,V.; Ward,P.A. (1997. ) In vivo suppression of nf-κb and preservation of iκbα by interleukin- 10 and interleukin-13 .Journal of Clinical Investigation, , 100 (10 ) ,2443 -2448

Lentsch,A.B.; Shanley,T.P.; Ward,P.A. (1997. ) Interleukin-10 protects against igg immune complex-induced lung injury through suppression of nf-κb .FASEB Journal, , 11 (3 ) ,

Lentsch,A.B.; Miller,F.N.; Edwards,M.J. (1997. ) Interleukin-2-induced hepatic injury involves temporal patterns of cell adhesion in the microcirculation .American Journal of Physiology - Gastrointestinal and Liver Physiology, , 272 (4 35-4 ) ,G727 -G731

Crouch,L.D.; Lentsch,A.B.; Warner,R.L.; Johnson,K.J.; Ward,P.A. (1997. ) Regulatory effects of adrenal gland products in igg immune complex acute lung injury .FASEB Journal, , 11 (3 ) ,

Lentsch,A.B.; Edwards,M.J.; Sims,D.E.; Nakagawa,K.; Wellhausen,S.R.; Miller,F.N. (1996. ) Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce toxicity in c3h/hen mice .Journal of Leukocyte Biology, , 60 (1 ) ,51 -57

Lentsch,A.B.; Edwards,M.J.; Sims,D.E.; Nakagawa,K.; Miller,F.N. (1996. ) Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce toxicity in mice .FASEB Journal, , 10 (3 ) ,

Lentsch,A.B.; Edwards,M.J.; Miller,F.N. (1996. ) Interleukin-2 induces increased platelet-endothelium interactions: a potential mechanism of toxicity .Journal of Laboratory and Clinical Medicine, , 128 (1 ) ,75 -82

Nakagawa,K.; Miller,F.N.; Sims,D.E.; Lentsch,A.B.; Miyazaki,M.; Edwards,M.J. (1996. ) Mechanisms of interleukin-2-induced hepatic toxicity .Cancer Research, , 56 (3 ) ,507 -510

Edwards,M.J.; Gable,D.R.; Lentsch,A.B.; Richardson,J.D. (1996. ) The rationale for esophagectomy as the optimal therapy for barrett's esophagus with high-grade dysplasia .Annals of Surgery, , 223 (5 ) ,585 -591

Anderson,J.A.; Lentsch,A.B.; Hadjiminas,D.J.; Miller,F.N.; Martin,A.W.; Nakagawa,K.; Edwards,M.J. (1996. ) The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in c57bl/6 mice .Journal of Clinical Investigation, , 97 (8 ) ,1952 -1959

Lindberg,R.A.; Slaaf,D.W.; Lentsch,A.B.; Miller,F.N. (1994. ) Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occlusion .Microvascular Research, , 47 (2 ) ,203 -221

Prakash, Priya S; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A; Robinson, Bryce R H (2012. ) Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response.The journal of trauma and acute care surgery, , 73 (2 ) ,401-6; discussion 40 More Information

Tevar, Amit D; Clarke, Calissia; Wang, Jiang; Rudich, Steven M; Woodle, E Steve; Lentsch, Alex B; Edwards, Michael L (2010. ) Clinical review of nonalcoholic steatohepatitis in liver surgery and transplantation.Journal of the American College of Surgeons, , 210 (4 ) ,515-26 More Information

Husted, Thomas L; Lentsch, Alex B (2006. ) The role of cytokines in pharmacological modulation of hepatic ischemia/reperfusion injury. Current pharmaceutical design, , 12 (23 ) ,2867-73

Lentsch, A B; Jordan, J A; Czermak, B J; Diehl, K M; Younkin, E M; Sarma, V; Ward, P A (1999. ) Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation. The American journal of pathology, , 154 (1 ) ,239-47

Stewart, Rachel K; Dangi, Anil; Huang, Chao; Murase, Noriko; Kimura, Shoko; Stolz, Donna B; Wilson, Gregory C; Lentsch, Alex B; Gandhi, Chandrashekhar R (2014. ) A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.Journal of hepatology, , 60 (2 ) ,298-305 More Information

Goodman, Michael D; Makley, Amy T; Campion, Eric M; Friend, Lou Ann W; Lentsch, Alex B; Pritts, Timothy A (2013. ) Preinjury alcohol exposure attenuates the neuroinflammatory response to traumatic brain injury.The Journal of surgical research, , 184 (2 ) ,1053-8 More Information

Yang, Sung H; Gustafson, Josh; Gangidine, Matt; Stepien, David; Schuster, Rebecca; Pritts, Timothy A; Goodman, Michael D; Remick, Daniel G; Lentsch, Alex B (2013. ) A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits.The Journal of surgical research, , 184 (2 ) ,981-8 More Information

Uriarte, Silvia M; Rane, Madhavi J; Merchant, Michael L; Jin, Shunying; Lentsch, Alex B; Ward, Richard A; McLeish, Kenneth R (2013. ) Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats.Shock (Augusta, Ga.), , 39 (3 ) ,286-92 More Information

Van Sweringen, Heather L; Sakai, Nozomu; Quillin, Ralph C; Bailey, Jeff; Schuster, Rebecca; Blanchard, John; Goetzman, Holly; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2013. ) Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice.Hepatology (Baltimore, Md.), , 57 (1 ) ,331-8 More Information

Sakai, Nozomu; Van Sweringen, Heather L; Quillin, R Cutler; Schuster, Rebecca; Blanchard, John; Burns, Justin M; Tevar, Amit D; Edwards, Michael J; Lentsch, Alex B (2012. ) Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice.Hepatology (Baltimore, Md.), , 56 (4 ) ,1468-78 More Information

Sakai, Nozomu; Van Sweringen, Heather L; Belizaire, Ritha M; Quillin, Ralph Cutler; Schuster, Rebecca; Blanchard, John; Burns, Justin M; Tevar, Amit D; Edwards, Michael J; Lentsch, Alex B (2012. ) Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells.Journal of gastroenterology and hepatology, , 27 (10 ) ,1609-16 More Information

Zahedi, Kamyar; Barone, Sharon L; Xu, Jie; Steinbergs, Nora; Schuster, Rebecca; Lentsch, Alex B; Amlal, Hassane; Wang, Jiang; Casero, Robert A; Soleimani, Manoocher (2012. ) Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 303 (5 ) ,G546-60 More Information

Belizaire, Ritha M; Makley, Amy T; Campion, Eric M; Sonnier, Dennis I; Goodman, Michael D; Dorlac, Warren C; Friend, Lou Ann; Lentsch, Alex B; Pritts, Timothy A (2012. ) Resuscitation with washed aged packed red blood cell units decreases the proinflammatory response in mice after hemorrhage.The journal of trauma and acute care surgery, , 73 (2 Suppl 1 ) ,S128-33 More Information

Belizaire, Ritha M; Prakash, Priya S; Richter, Jillian R; Robinson, Bryce R; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation.Journal of the American College of Surgeons, , 214 (4 ) ,648-55; discussion 6 More Information

Sakai, Nozomu; Van Sweringen, Heather L; Schuster, Rebecca; Blanchard, John; Burns, Justin M; Tevar, Amit D; Edwards, Michael J; Lentsch, Alex B (2012. ) Receptor activator of nuclear factor-?B ligand (RANKL) protects against hepatic ischemia/reperfusion injury in mice.Hepatology (Baltimore, Md.), , 55 (3 ) ,888-97 More Information

Huber, Nathan L; Bailey, Stephanie R; Schuster, Rebecca; Ogle, Cora K; Lentsch, Alex B; Pritts, Timothy A Prior thermal injury accelerates endotoxin-induced inflammatory cytokine production and intestinal nuclear factor-?B activation in mice.Journal of burn care & research : official publication of the American Burn Association, , 33 (2 ) ,279-85 More Information

Lentsch, Alex B (2012. ) Regulatory mechanisms of injury and repair after hepatic ischemia/reperfusion.Scientifica, , 2012 ,513192 More Information

Sonnier, Dennis I; Bailey, Stephanie R; Schuster, Rebecca M; Gangidine, Matthew M; Lentsch, Alex B; Pritts, Timothy A (2012. ) Proinflammatory chemokines in the intestinal lumen contribute to intestinal dysfunction during endotoxemia.Shock (Augusta, Ga.), , 37 (1 ) ,63-9 More Information

Clarke, Callisia; Sakai, Nozomu; Tevar, Amit D; Schuster, Rebecca; Edwards, Michael J; Lentsch, Alex B (2011. ) STAT3 does not regulate acute liver injury after ischemia/reperfusion.The Journal of surgical research, , 171 (2 ) ,814-8 More Information

Van Sweringen, Heather L; Sakai, Nozomu; Tevar, Amit D; Burns, Justin M; Edwards, Michael J; Lentsch, Alex B (2011. ) CXC chemokine signaling in the liver: impact on repair and regeneration.Hepatology (Baltimore, Md.), , 54 (4 ) ,1445-53 More Information

Sonnier, Dennis I; Makley, Amy T; Friend, Lou Ann W; Bailey, Stephanie R; Lentsch, Alex B; Pritts, Timothy A (2011. ) Hemorrhagic shock induces a proinflammatory milieu in the gut lumen.The Journal of surgical research, , 170 (2 ) ,272-9 More Information

Sakai, Nozomu; Shin, Thomas; Schuster, Rebecca; Blanchard, John; Lentsch, Alex B; Johnson, William Thomas; Schuschke, Dale A (2011. ) Marginal copper deficiency increases liver neutrophil accumulation after ischemia/reperfusion in rats.Biological trace element research, , 142 (1 ) ,47-54 More Information

Tevar, Amit D; Clarke, Callisia N; Schuster, Rebecca; Wang, Jiang; Edwards, Michael J; Lentsch, Alex B (2011. ) The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis.The Journal of surgical research, , 169 (1 ) ,e7-14 More Information

Clarke, Callisia; Kuboki, Satoshi; Sakai, Nozomu; Kasten, Kevin R; Tevar, Amit D; Schuster, Rebecca; Blanchard, John; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2011. ) CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.Hepatology (Baltimore, Md.), , 53 (1 ) ,261-71 More Information

Goodman, Michael D; Makley, Amy T; Huber, Nathan L; Clarke, Callisia N; Friend, Lou Ann W; Schuster, Rebecca M; Bailey, Stephanie R; Barnes, Stephen L; Dorlac, Warren C; Johannigman, Jay A; Lentsch, Alex B; Pritts, Timothy A (2011. ) Hypobaric hypoxia exacerbates the neuroinflammatory response to traumatic brain injury.The Journal of surgical research, , 165 (1 ) ,30-7 More Information

Goodman, Michael D; Makley, Amy T; Lentsch, Alex B; Barnes, Stephen L; Dorlac, Gina R; Dorlac, Warren C; Johannigman, Jay A; Pritts, Timothy A (2010. ) Traumatic brain injury and aeromedical evacuation: when is the brain fit to fly?.The Journal of surgical research, , 164 (2 ) ,286-93 More Information

Sonnier, Dennis I; Bailey, Stephanie R; Schuster, Rebecca M; Lentsch, Alex B; Pritts, Timothy A (2010. ) TNF-? induces vectorial secretion of IL-8 in Caco-2 cells.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , 14 (10 ) ,1592-9 More Information

Sakai, Nozomu; Clarke, Callisia N; Schuster, Rebecca; Blanchard, John; Tevar, Amit D; Edwards, Michael J; Lentsch, Alex B (2010. ) Portal vein ligation accelerates tumor growth in ligated, but not contralateral lobes. World journal of gastroenterology : WJG, , 16 (30 ) ,3816-26

Huber, Nathan L; Bailey, Stephanie R; Schuster, Rebecca M; Ogle, Cora K; Lentsch, Alex B; Pritts, Timothy A (2010. ) Remote thermal injury increases LPS-induced intestinal IL-6 production.The Journal of surgical research, , 160 (2 ) ,190-5 More Information

Kasten, Kevin R; Goetzman, Holly S; Reid, Maria R; Rasper, Alison M; Adediran, Samuel G; Robinson, Chad T; Cave, Cindy M; Solomkin, Joseph S; Lentsch, Alex B; Johannigman, Jay A; Caldwell, Charles C (2010. ) Divergent adaptive and innate immunological responses are observed in humans following blunt trauma.BMC immunology, , 11 ,4 More Information

Clarke, Callisia N; Kuboki, Satoshi; Tevar, Amit; Lentsch, Alex B; Edwards, Michael (2009. ) CXC chemokines play a critical role in liver injury, recovery, and regeneration.American journal of surgery, , 198 (3 ) ,415-9 More Information

Zingarelli, Basilia; Hake, Paul W; O'Connor, Michael; Burroughs, Timothy J; Wong, Hector R; Solomkin, Joseph S; Lentsch, Alex B (2009. ) Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma.Critical care medicine, , 37 (6 ) ,1978-87 More Information

Huber, Nadine; Sakai, Nozomu; Eismann, Thorsten; Shin, Thomas; Kuboki, Satoshi; Blanchard, John; Schuster, Rebecca; Edwards, Michael J; Wong, Hector R; Lentsch, Alex B (2009. ) Age-related decrease in proteasome expression contributes to defective nuclear factor-kappaB activation during hepatic ischemia/reperfusion.Hepatology (Baltimore, Md.), , 49 (5 ) ,1718-28 More Information

Golab, Fereshteh; Kadkhodaee, Mehri; Zahmatkesh, Maryam; Hedayati, Mehdi; Arab, Hossein; Schuster, Rebecca; Zahedi, Kamyar; Lentsch, Alex B; Soleimani, Manoocher (2009. ) Ischemic and non-ischemic acute kidney injury cause hepatic damage.Kidney international, , 75 (8 ) ,783-92 More Information

Eismann, Thorsten; Huber, Nadine; Shin, Thomas; Kuboki, Satoshi; Galloway, Elizabeth; Wyder, Michael; Edwards, Michael J; Greis, Kenneth D; Shertzer, Howard G; Fisher, Aron B; Lentsch, Alex B (2009. ) Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice.American journal of physiology. Gastrointestinal and liver physiology, , 296 (2 ) ,G266-74 More Information

Lewis, Jaime D; Pritts, Timothy A; Lentsch, Alex B; Edwards, Michael J (2009. ) The University of Cincinnati College of Medicine Department of Surgery. The American surgeon, , 75 (2 ) ,113-9

Flierl, Michael A; Rittirsch, Daniel; Nadeau, Brian A; Sarma, J Vidya; Day, Danielle E; Lentsch, Alex B; Huber-Lang, Markus S; Ward, Peter A (2009. ) Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response.PloS one, , 4 (2 ) ,e4414 More Information

Caldwell, Charles C; Lentsch, Alex B (2008. ) Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.Gastroenterology, , 135 (5 ) ,1460-2 More Information

Kuboki, Satoshi; Shin, Thomas; Huber, Nadine; Eismann, Thorsten; Galloway, Elizabeth; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Lentsch, Alex B (2008. ) Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice.Hepatology (Baltimore, Md.), , 48 (4 ) ,1213-23 More Information

Shin, Thomas; Kuboki, Satoshi; Lentsch, Alex B (2008. ) Roles of nuclear factor-kappaB in postischemic liver.Hepatology research : the official journal of the Japan Society of Hepatology, , 38 (5 ) ,429-40 More Information

Tschöp, Johannes; Martignoni, André; Goetzman, Holly S; Choi, Lisa G; Wang, Quan; Noel, John G; Ogle, Cora K; Pritts, Timothy A; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) Gammadelta T cells mitigate the organ injury and mortality of sepsis.Journal of leukocyte biology, , 83 (3 ) ,581-8 More Information

Kuboki, Satoshi; Shin, Thomas; Huber, Nadine; Eismann, Thorsten; Galloway, Elizabeth; Schuster, Rebecca; Blanchard, John; Zingarelli, Basilia; Lentsch, Alex B (2008. ) Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice.Hepatology (Baltimore, Md.), , 47 (1 ) ,215-24 More Information

Caldwell, Charles C; Tschoep, Johannes; Lentsch, Alex B (2007. ) Lymphocyte function during hepatic ischemia/reperfusion injury.Journal of leukocyte biology, , 82 (3 ) ,457-64 More Information

Solomkin, Joseph S; Robinson, Chad T; Cave, Cynthia M; Ehmer, Birgit; Lentsch, Alex B (2007. ) Alterations in membrane cholesterol cause mobilization of lipid rafts from specific granules and prime human neutrophils for enhanced adherence-dependent oxidant production.Shock (Augusta, Ga.), , 28 (3 ) ,334-8 More Information

Kuboki, Satoshi; Schuster, Rebecca; Blanchard, John; Pritts, Timothy A; Wong, Hector R; Lentsch, Alex B (2007. ) Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice.American journal of physiology. Gastrointestinal and liver physiology, , 292 (4 ) ,G1141-9 More Information

Lentsch, Alex B; Pathrose, Peterson; Kader, Sarah; Kuboki, Satoshi; Collins, Margaret H; Waltz, Susan E (2007. ) The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation.Shock (Augusta, Ga.), , 27 (3 ) ,274-80 More Information

Kuboki, Satoshi; Okaya, Tomohisa; Schuster, Rebecca; Blanchard, John; Denenberg, Alvin; Wong, Hector R; Lentsch, Alex B (2007. ) Hepatocyte NF-kappaB activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G201-7 More Information

Shen, Hui; Schuster, Rebecca; Lu, Bao; Waltz, Susan E; Lentsch, Alex B (2006. ) Critical and opposing roles of the chemokine receptors CXCR2 and CXCR3 in prostate tumor growth.The Prostate, , 66 (16 ) ,1721-8 More Information

Lentsch, Alex B (2006. ) CXC chemokines and prostate cancer: growth regulators and potential biomarkers.Future oncology (London, England), , 2 (5 ) ,651-8 More Information

Toledo-Pereyra, Luis H; Lopez-Neblina, Fernando; Lentsch, Alex B; Anaya-Prado, Roberto; Romano, Suzanne J; Ward, Peter A Selectin inhibition modulates NF-kappa B and AP-1 signaling after liver ischemia/reperfusion.Journal of investigative surgery : the official journal of the Academy of Surgical Research, , 19 (5 ) ,313-22 More Information

Husted, T L; Blanchard, J; Schuster, R; Shen, H; Lentsch, A B (2006. ) Potential role for IL-23 in hepatic ischemia/reperfusion injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , 55 (5 ) ,177-8 More Information

Thakar, Charuhas V; Zahedi, Kamyar; Revelo, Monica P; Wang, Zhaohui; Burnham, Charles E; Barone, Sharon; Bevans, Shannon; Lentsch, Alex B; Rabb, Hamid; Soleimani, Manoocher (2005. ) Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia.The Journal of clinical investigation, , 115 (12 ) ,3451-9 More Information

Okaya, Tomohisa; Blanchard, John; Schuster, Rebecca; Kuboki, Satoshi; Husted, Thomas; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector; Solomkin, Joseph S; Lentsch, Alex B (2005. ) Age-dependent responses to hepatic ischemia/reperfusion injury. Shock (Augusta, Ga.), , 24 (5 ) ,421-7

Gordon, Sharon A; Lominadze, David; Saari, Jack T; Lentsch, Alex B; Schuschke, Dale A (2005. ) Impaired deformability of copper-deficient neutrophils. Experimental biology and medicine (Maywood, N.J.), , 230 (8 ) ,543-8

Husted, Thomas L; Govindaswami, Meera; Oeltgen, Peter R; Rudich, Steven M; Lentsch, Alex B (2005. ) A delta2-opioid agonist inhibits p38 MAPK and suppresses activation of murine macrophages.The Journal of surgical research, , 128 (1 ) ,45-9 More Information

Mayhew, Christopher N; Bosco, Emily E; Fox, Sejal R; Okaya, Tomohisa; Tarapore, Pheruza; Schwemberger, Sandy J; Babcock, George F; Lentsch, Alex B; Fukasawa, Kenji; Knudsen, Erik S (2005. ) Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy.Cancer research, , 65 (11 ) ,4568-77 More Information

Okaya, Tomohisa; Lentsch, Alex B (2005. ) Hepatic expression of S32A/S36A IkappaBalpha does not reduce postischemic liver injury.The Journal of surgical research, , 124 (2 ) ,244-9 More Information

Williams, Mark A; Cave, Cindy M; Quaid, Gina; Robinson, Chad; Daly, Thomas J; Witt, Dan; Lentsch, Alex B; Solomkin, Joseph S (2005. ) Interleukin 8 dimerization as a mechanism for regulation of neutrophil adherence-dependent oxidant production. Shock (Augusta, Ga.), , 23 (4 ) ,371-6

Okaya, T; Holthaus, R; Kato, A; Lentsch, A B (2004. ) Involvement of the neuropeptide substance P in lung inflammation induced by hepatic ischemia/reperfusion.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , 53 (6 ) ,257-61 More Information

Shen, Hui; Lentsch, Alex B (2004. ) Progressive dysregulation of transcription factors NF-kappa B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines.American journal of physiology. Cell physiology, , 286 (4 ) ,C840-7 More Information

Okaya, Tomohisa; Lentsch, Alex B (2004. ) Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 286 (4 ) ,G606-12 More Information

Umanskiy, Konstantin; Robinson, Chad; Cave, Cindy; Williams, Mark A; Lentsch, Alex B; Cuschieri, Joseph; Solomkin, Joseph S (2003. ) NADPH oxidase activation in fibronectin adherent human neutrophils: A potential role for beta1 integrin ligation.Surgery, , 134 (2 ) ,378-83 More Information

Okaya, Tomohisa; Lentsch, Alex B Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion. Journal of investigative surgery : the official journal of the Academy of Surgical Research, , 16 (3 ) ,141-7

Kato, Atsushi; Okaya, Tomohisa; Lentsch, Alex B (2003. ) Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury.Hepatology (Baltimore, Md.), , 37 (2 ) ,304-12 More Information

Schuschke, Dale A; Percival, Susan S; Lominadze, David; Saari, Jack T; Lentsch, Alex B (2002. ) Tissue-specific ICAM-1 expression and neutrophil transmigration in the copper-deficient rat. Inflammation, , 26 (6 ) ,297-303

Kato, Atsushi; Gabay, Cem; Okaya, Tomohisa; Lentsch, Alex B (2002. ) Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion.The American journal of pathology, , 161 (5 ) ,1797-803 More Information

Guo, Ren-Feng; Lentsch, Alex B; Sarma, J Vidya; Sun, Lei; Riedemann, Niels C; McClintock, Shannon D; McGuire, Stephanie R; Van Rooijen, Nico; Ward, Peter A (2002. ) Activator protein-1 activation in acute lung injury.The American journal of pathology, , 161 (1 ) ,275-82 More Information

Lentsch, Alex B (2002. ) The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white?.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 16 (9 ) ,1093-5 More Information

Kato, Atsushi; Edwards, Michael J; Lentsch, Alex B (2002. ) Gene deletion of NF-kappa B p50 does not alter the hepatic inflammatory response to ischemia/reperfusion. Journal of hepatology, , 37 (1 ) ,48-55

Anaya-Prado, Roberto; Toledo-Pereyra, Luis H; Lentsch, Alex B; Ward, Peter A (2002. ) Ischemia/reperfusion injury. The Journal of surgical research, , 105 (2 ) ,248-58

Ward, Peter A; Lentsch, Alex B Endogenous regulation of the acute inflammatory response. Molecular and cellular biochemistry, , 234-235 (1-2 ) ,225-8

Kato, Atsushi; Singh, Saurabh; McLeish, Kenneth R; Edwards, Michael J; Lentsch, Alex B (2002. ) Mechanisms of hypothermic protection against ischemic liver injury in mice.American journal of physiology. Gastrointestinal and liver physiology, , 282 (4 ) ,G608-16 More Information

Lentsch, A B; Kato, A; Davis, B; Wang, W; Chao, C; Edwards, M J (2001. ) STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia.The Journal of clinical investigation, , 108 (10 ) ,1475-82 More Information

Lentsch, A B; Ward, P A (2001. ) Regulation of experimental lung inflammation. Respiration physiology, , 128 (1 ) ,17-22

Lentsch, A B; Kato, A; Saari, J T; Schuschke, D A (2001. ) Augmented metalloproteinase activity and acute lung injury in copper-deficient rats. American journal of physiology. Lung cellular and molecular physiology, , 281 (2 ) ,L387-93

Guo, R F; Lentsch, A B; Warner, R L; Huber-Lang, M; Sarma, J V; Hlaing, T; Shi, M M; Lukacs, N W; Ward, P A (2001. ) Regulatory effects of eotaxin on acute lung inflammatory injury. Journal of immunology (Baltimore, Md. : 1950), , 166 (8 ) ,5208-18

Molestina, R E; Miller, R D; Lentsch, A B; Ramirez, J A; Summersgill, J T (2000. ) Requirement for NF-kappaB in transcriptional activation of monocyte chemotactic protein 1 by Chlamydia pneumoniae in human endothelial cells. Infection and immunity, , 68 (7 ) ,4282-8

Kato, A; Yoshidome, H; Edwards, M J; Lentsch, A B (2000. ) Reduced hepatic ischemia/reperfusion injury by IL-4: potential anti-inflammatory role of STAT6. Inflammation research : official journal of the European Histamine Research Society ... [et al.], , 49 (6 ) ,275-9

Mulligan, M S; Lentsch, A B; Huber-Lang, M; Guo, R F; Sarma, V; Wright, C D; Ulich, T R; Ward, P A (2000. ) Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor.The American journal of pathology, , 156 (3 ) ,1033-9 More Information

Bless, N M; Huber-Lang, M; Guo, R F; Warner, R L; Schmal, H; Czermak, B J; Shanley, T P; Crouch, L D; Lentsch, A B; Sarma, V; Mulligan, M S; Friedl, H P; Ward, P A (2000. ) Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats. Journal of immunology (Baltimore, Md. : 1950), , 164 (5 ) ,2650-9

Lentsch, A B; Ward, P A (2000. ) Regulation of inflammatory vascular damage.The Journal of pathology, , 190 (3 ) ,343-8 More Information

Lentsch, A B; Ward, P A (2000. ) The NFkappaBb/IkappaB system in acute inflammation. Archivum immunologiae et therapiae experimentalis, , 48 (2 ) ,59-63

Yoshidome, H; Kato, A; Miyazaki, M; Edwards, M J; Lentsch, A B (1999. ) IL-13 activates STAT6 and inhibits liver injury induced by ischemia/reperfusion.The American journal of pathology, , 155 (4 ) ,1059-64 More Information

Lentsch, A B; Yoshidome, H; Warner, R L; Ward, P A; Edwards, M J (1999. ) Secretory leukocyte protease inhibitor in mice regulates local and remote organ inflammatory injury induced by hepatic ischemia/reperfusion. Gastroenterology, , 117 (4 ) ,953-61

Lentsch, Alex B.; Ward, Peter A. (1999. ) Understanding the Pathogenesis of Inflammation Using Rodent Models: Identification of a Transcription Factor (NFkappaB) Necessary for Development of Inflammatory Injury. ILAR journal / National Research Council, Institute of Laboratory Animal Resources, , 40 (4 ) ,151-156

Yoshidome, H; Kato, A; Edwards, M J; Lentsch, A B (1999. ) Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: implications of a central role for nuclear factor kappaB.Hepatology (Baltimore, Md.), , 30 (1 ) ,203-8 More Information

Lentsch, A B; Crouch, L D; Jordan, J A; Czermak, B J; Yun, E C; Guo, R; Sarma, V; Diehl, K M; Ward, P A (1999. ) Regulatory effects of interleukin-11 during acute lung inflammatory injury. Journal of leukocyte biology, , 66 (1 ) ,151-7

Ward, P A; Lentsch, A B (1999. ) The acute inflammatory response and its regulation. Archives of surgery (Chicago, Ill. : 1960), , 134 (6 ) ,666-9

Czermak, B J; Lentsch, A B; Bless, N M; Schmal, H; Friedl, H P; Ward, P A (1999. ) Synergistic enhancement of chemokine generation and lung injury by C5a or the membrane attack complex of complement.The American journal of pathology, , 154 (5 ) ,1513-24 More Information

Lentsch, A B; Czermak, B J; Jordan, J A; Ward, P A (1999. ) Regulation of acute lung inflammatory injury by endogenous IL-13. Journal of immunology (Baltimore, Md. : 1950), , 162 (2 ) ,1071-6

Bless, N M; Warner, R L; Padgaonkar, V A; Lentsch, A B; Czermak, B J; Schmal, H; Friedl, H P; Ward, P A (1999. ) Roles for C-X-C chemokines and C5a in lung injury after hindlimb ischemia-reperfusion. The American journal of physiology, , 276 (1 Pt 1 ) ,L57-63

Schmal, H; Czermak, B J; Lentsch, A B; Bless, N M; Beck-Schimmer, B; Friedl, H P; Ward, P A (1998. ) Soluble ICAM-1 activates lung macrophages and enhances lung injury. Journal of immunology (Baltimore, Md. : 1950), , 161 (7 ) ,3685-93

Mulligan, M S; Lentsch, A B; Shanley, T P; Miyasaka, M; Johnson, K J; Ward, P A (1998. ) Cytokine and adhesion molecule requirements for lung injury induced by anti-glomerular basement membrane antibody. Inflammation, , 22 (4 ) ,403-17

Mulligan, M S; Lentsch, A B; Miyasaka, M; Ward, P A (1998. ) Cytokine and adhesion molecule requirements for neutrophil recruitment during glycogen-induced peritonitis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], , 47 (6 ) ,251-5

Mulligan, M S; Lentsch, A B; Ward, P A (1998. ) In vivo recruitment of neutrophils: consistent requirements for L-arginine and variable requirements for complement and adhesion molecules. Inflammation, , 22 (3 ) ,327-39

Lentsch, A B; Edwards, M J; Sims, D E; Miller, F N (1998. ) N omega-nitro-L-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2. Journal of leukocyte biology, , 63 (1 ) ,22-30

Lentsch, A B; Miller, F N; Edwards, M J (1997. ) Interleukin-2-induced hepatic injury involves temporal patterns of cell adhesion in the microcirculation. The American journal of physiology, , 272 (4 Pt 1 ) ,G727-31

Lentsch, A B; Nakagawa, K; Yoshidome, H; Gerassimides, A; Miller, F N; Edwards, M J (1997. ) Distinct biological activities of recombinant forms of human interleukin-2 in vivo. Cancer immunology, immunotherapy : CII, , 43 (6 ) ,331-6

Lentsch, A B; Edwards, M J; Miller, F N (1996. ) Interleukin-2 induces increased platelet-endothelium interactions: a potential mechanism of toxicity. The Journal of laboratory and clinical medicine, , 128 (1 ) ,75-82

Edwards, M J; Gable, D R; Lentsch, A B; Richardson, J D (1996. ) The rationale for esophagectomy as the optimal therapy for Barrett's esophagus with high-grade dysplasia. Annals of surgery, , 223 (5 ) ,585-9; discussion 58

Anderson, J A; Lentsch, A B; Hadjiminas, D J; Miller, F N; Martin, A W; Nakagawa, K; Edwards, M J (1996. ) The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice.The Journal of clinical investigation, , 97 (8 ) ,1952-9 More Information

Chatterjee, Tapan K; Basford, Joshua E; Knoll, Ellen; Tong, Wilson S; Blanco, Victor; Blomkalns, Andra L; Rudich, Steven; Lentsch, Alex B; Hui, David Y; Weintraub, Neal L (2014. ) HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding.Diabetes, , 63 (1 ) ,176-87 More Information

Yang, Sung H; Gangidine, Matt; Pritts, Timothy A; Goodman, Michael D; Lentsch, Alex B (2013. ) Interleukin 6 mediates neuroinflammation and motor coordination deficits after mild traumatic brain injury and brief hypoxia in mice.Shock (Augusta, Ga.), , 40 (6 ) ,471-5 More Information

Ziobro, Regan; Henry, Brian; Edwards, Michael J; Lentsch, Alex B; Gulbins, Erich (2013. ) Ceramide mediates lung fibrosis in cystic fibrosis.Biochemical and biophysical research communications, , 434 (4 ) ,705-9 More Information

Makley, Amy T; Belizaire, Ritha; Campion, Eric M; Goodman, Michael D; Sonnier, Dennis I; Friend, Lou Ann; Schuster, Rebecca M; Bailey, Stephanie R; Johannigman, Jay A; Dorlac, Warren C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Simulated aeromedical evacuation does not affect systemic inflammation or organ injury in a murine model of hemorrhagic shock. Military medicine, , 177 (8 ) ,911-6

Earnest, Ryan E; Sonnier, Dennis I; Makley, Amy T; Campion, Eric M; Wenke, Joseph C; Bailey, Stephanie R; Dorlac, Warren C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Supplemental oxygen attenuates the increase in wound bacterial growth during simulated aeromedical evacuation in goats.The journal of trauma and acute care surgery, , 73 (1 ) ,80-6 More Information

Makley, Amy T; Goodman, Michael D; Belizaire, Ritha M; Friend, Lou Ann W; Johannigman, Jay A; Dorlac, Warren C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Damage control resuscitation decreases systemic inflammation after hemorrhage.The Journal of surgical research, , 175 (2 ) ,e75-82 More Information

Thobe, M N; Gray, J K; Gurusamy, D; Paluch, A M; Wagh, P K; Pathrose, P; Lentsch, A B; Waltz, S E (2011. ) The Ron receptor promotes prostate tumor growth in the TRAMP mouse model.Oncogene, , 30 (50 ) ,4990-8 More Information

Sakai, N; Kuboki, S; Van Sweringen, H L; Tevar, A D; Schuster, R; Blanchard, J; Edwards, M J; Lentsch, A B (2011. ) CXCR1 deficiency does not alter liver regeneration after partial hepatectomy in mice.Transplantation proceedings, , 43 (5 ) ,1967-70 More Information

Elson, Joshua K; Beebe-Dimmer, Jennifer L; Morgenstern, Hal; Chilkuri, Mahdavi; Blanchard, John; Lentsch, Alex B (2011. ) The Duffy Antigen/Receptor for Chemokines (DARC) and prostate-cancer risk among Jamaican men.Journal of immigrant and minority health / Center for Minority Public Health, , 13 (1 ) ,36-41 More Information

Makley, Amy T; Goodman, Michael D; Friend, Lou Ann W; Johannigman, Jay A; Dorlac, Warren C; Lentsch, Alex B; Pritts, Timothy A (2010. ) Murine blood banking: characterization and comparisons to human blood.Shock (Augusta, Ga.), , 34 (1 ) ,40-5 More Information

Makley, Amy T; Goodman, Michael D; Friend, Lou Ann W; Deters, Joseph S; Johannigman, Jay A; Dorlac, Warren C; Lentsch, Alex B; Pritts, Timothy A (2010. ) Resuscitation with fresh whole blood ameliorates the inflammatory response after hemorrhagic shock.The Journal of trauma, , 68 (2 ) ,305-11 More Information

Kuboki, Satoshi; Sakai, Nozomu; Clarke, Callisia; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Lentsch, Alex B (2009. ) The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury.Journal of hepatology, , 51 (2 ) ,296-306 More Information

Tschöp, Johannes; Kasten, Kevin R; Nogueiras, Ruben; Goetzman, Holly S; Cave, Cynthia M; England, Lisa G; Dattilo, Jonathan; Lentsch, Alex B; Tschöp, Matthias H; Caldwell, Charles C (2009. ) The cannabinoid receptor 2 is critical for the host response to sepsis.Journal of immunology (Baltimore, Md. : 1950), , 183 (1 ) ,499-505 More Information

Kuboki, Satoshi; Sakai, Nozomu; Tschöp, Johannes; Edwards, Michael J; Lentsch, Alex B; Caldwell, Charles C (2009. ) Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 296 (5 ) ,G1054-9 More Information

Zahedi, Kamyar; Lentsch, Alex B; Okaya, Tomohisa; Barone, Sharon; Sakai, Nozomu; Witte, David P; Arend, Lois J; Alhonen, Leena; Jell, Jason; Jänne, Juhani; Porter, Carl W; Soleimani, Manoocher (2009. ) Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.American journal of physiology. Gastrointestinal and liver physiology, , 296 (4 ) ,G899-909 More Information

Galloway, Elizabeth; Shin, Thomas; Huber, Nadine; Eismann, Thorsten; Kuboki, Satoshi; Schuster, Rebecca; Blanchard, John; Wong, Hector R; Lentsch, Alex B (2008. ) Activation of hepatocytes by extracellular heat shock protein 72.American journal of physiology. Cell physiology, , 295 (2 ) ,C514-20 More Information

Shin, Thomas; Kuboki, Satoshi; Huber, Nadine; Eismann, Thorsten; Galloway, Elizabeth; Schuster, Rebecca; Blanchard, John; Pritts, Timothy A; Lentsch, Alex B (2008. ) Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent.The Journal of surgical research, , 147 (2 ) ,200-5 More Information

Martignoni, André; Tschöp, Johannes; Goetzman, Holly S; Choi, Lisa G; Reid, Maria D; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) CD4-expressing cells are early mediators of the innate immune system during sepsis.Shock (Augusta, Ga.), , 29 (5 ) ,591-7 More Information

Thiel, Manfred; Caldwell, Charles C; Kreth, Simone; Kuboki, Satoshi; Chen, P; Smith, Patrick; Ohta, Akio; Lentsch, Alex B; Lukashev, Dmitry; Sitkovsky, Michail V (2007. ) Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.PloS one, , 2 (9 ) ,e853 More Information

Saari, Jack T; Wold, Loren E; Duan, Jinhong; Ren, Jun; Carlson, Hanqian L; Bode, Ann M; Lentsch, Alex B; Zeng, Huawei; Schuschke, Dale A (2007. ) Cardiac nitric oxide synthases are elevated in dietary copper deficiency.The Journal of nutritional biochemistry, , 18 (7 ) ,443-8 More Information

Solomkin, Joseph S; Robinson, Chad T; Cave, Cynthia M; Umanskiy, Konstantin; Matlin, Karl; Williams, Mark A; Lentsch, Alex B (2006. ) Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space.Shock (Augusta, Ga.), , 25 (5 ) ,440-5 More Information

Mallakin, Ali; Kutcher, Louis W; McDowell, Susan A; Kong, Sue; Schuster, Rebecca; Lentsch, Alex B; Aronow, Bruce J; Leikauf, George D; Waltz, Susan E (2006. ) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury.American journal of respiratory cell and molecular biology, , 34 (1 ) ,15-27 More Information

Shen, Hui; Schuster, Rebecca; Stringer, Keith F; Waltz, Susan E; Lentsch, Alex B (2006. ) The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 20 (1 ) ,59-64 More Information

Caldwell, Charles C; Okaya, Tomohisa; Martignoni, Andre; Husted, Thomas; Schuster, Rebecca; Lentsch, Alex B (2005. ) Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion.American journal of physiology. Gastrointestinal and liver physiology, , 289 (5 ) ,G969-76 More Information

Barone, Sharon; Okaya, Tomohisa; Rudich, Steve; Petrovic, Snezana; Tenrani, Kathy; Wang, Zhaohui; Zahedi, Kamyar; Casero, Robert A; Lentsch, Alex B; Soleimani, Manoocher (2005. ) Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury.American journal of physiology. Cell physiology, , 289 (4 ) ,C826-35 More Information

Lentsch, Alex B (2005. ) Activation and function of hepatocyte NF-kappaB in postischemic liver injury.Hepatology (Baltimore, Md.), , 42 (1 ) ,216-8 More Information

Husted, Thomas L; Lentsch, Alex B (2005. ) Anti-inflammatory approaches to the prevention of ischemia/reperfusion injury in solid organ transplantation. Current opinion in investigational drugs (London, England : 2000), , 6 (5 ) ,508-12

Kato, Atsushi; Graul-Layman, Amanda; Edwards, Michael J; Lentsch, Alex B (2002. ) Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4. Transplantation, , 73 (7 ) ,1142-5

Godshall, C J; Lentsch, A B; Peyton, J C; Scott, M J; Cheadle, W G (2001. ) STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis.Clinical and diagnostic laboratory immunology, , 8 (6 ) ,1044-8 More Information

Dawson, T C; Lentsch, A B; Wang, Z; Cowhig, J E; Rot, A; Maeda, N; Peiper, S C (2000. ) Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood, , 96 (5 ) ,1681-4

Lentsch, A B; Kato, A; Yoshidome, H; McMasters, K M; Edwards, M J (2000. ) Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury.Hepatology (Baltimore, Md.), , 32 (2 ) ,169-73 More Information

Kato, A; Yoshidome, H; Edwards, M J; Lentsch, A B (2000. ) Regulation of liver inflammatory injury by signal transducer and activator of transcription-6.The American journal of pathology, , 157 (1 ) ,297-302 More Information

Yoshidome, H; Miyazaki, M; Shimizu, H; Ito, H; Nakagawa, K; Ambiru, S; Nakajima, N; Edwards, M J; Lentsch, A B (2000. ) Obstructive jaundice impairs hepatic sinusoidal endothelial cell function and renders liver susceptible to hepatic ischemia/reperfusion. Journal of hepatology, , 33 (1 ) ,59-67

Lentsch, A B; Yoshidome, H; Kato, A; Warner, R L; Cheadle, W G; Ward, P A; Edwards, M J (1999. ) Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice.Hepatology (Baltimore, Md.), , 30 (6 ) ,1448-53 More Information

Yoshidome, H; Kato, A; Edwards, M J; Lentsch, A B (1999. ) Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia-reperfusion. The American journal of physiology, , 277 (5 Pt 1 ) ,L919-23

Lentsch, A B; Czermak, B J; Bless, N M; Van Rooijen, N; Ward, P A (1999. ) Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.American journal of respiratory cell and molecular biology, , 20 (4 ) ,692-8 More Information

Lentsch, A B; Ward, P A (1999. ) Activation and regulation of NFkappaB during acute inflammation.Clinical chemistry and laboratory medicine : CCLM / FESCC, , 37 (3 ) ,205-8 More Information

Lentsch, A B; Miller, F N; Edwards, M J (1999. ) Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2. Cancer immunology, immunotherapy : CII, , 47 (5 ) ,243-8

Yoshidome, H; Lentsch, A B; Cheadle, W G; Miller, F N; Edwards, M J (1999. ) Enhanced pulmonary expression of CXC chemokines during hepatic ischemia/reperfusion-induced lung injury in mice.The Journal of surgical research, , 81 (1 ) ,33-7 More Information

Bless, N M; Tojo, S J; Kawarai, H; Natsume, Y; Lentsch, A B; Padgaonkar, V A; Czermak, B J; Schmal, H; Friedl, H P; Ward, P A (1998. ) Differing patterns of P-selectin expression in lung injury.The American journal of pathology, , 153 (4 ) ,1113-22 More Information

Czermak, B J; Lentsch, A B; Bless, N M; Schmal, H; Friedl, H P; Ward, P A (1998. ) Role of complement in in vitro and in vivo lung inflammatory reactions. Journal of leukocyte biology, , 64 (1 ) ,40-8

Lentsch, A B; Czermak, B J; Bless, N M; Ward, P A (1998. ) NF-kappaB activation during IgG immune complex-induced lung injury: requirements for TNF-alpha and IL-1beta but not complement. The American journal of pathology, , 152 (5 ) ,1327-36

Lentsch, A B; Yoshidome, H; Cheadle, W G; Miller, F N; Edwards, M J (1998. ) Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC.Hepatology (Baltimore, Md.), , 27 (4 ) ,1172-7 More Information

Lentsch, A B; Yoshidome, H; Cheadle, W G; Miller, F N; Edwards, M J (1998. ) Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and Kupffer cells.Hepatology (Baltimore, Md.), , 27 (2 ) ,507-12 More Information

Lentsch, A B; Shanley, T P; Sarma, V; Ward, P A (1997. ) In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.The Journal of clinical investigation, , 100 (10 ) ,2443-8 More Information

Lentsch, A B; Edwards, M J; Sims, D E; Nakagawa, K; Wellhausen, S R; Miller, F N (1996. ) Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice. Journal of leukocyte biology, , 60 (1 ) ,51-7

Nakagawa, K; Miller, F N; Sims, D E; Lentsch, A B; Miyazaki, M; Edwards, M J (1996. ) Mechanisms of interleukin-2-induced hepatic toxicity. Cancer research, , 56 (3 ) ,507-10

Lindberg, R A; Slaaf, D W; Lentsch, A B; Miller, F N (1994. ) Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occlusion.Microvascular research, , 47 (2 ) ,203-21 More Information

Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Freeman, Christopher H; Wang, Jiang; Schuster, Rebecca M; Blanchard, John A; Edwards, Michael J; Gandhi, Chandrashekhar R; Gulbins, Erich; Lentsch, Alex B (2014. ) Inhibition of Acidic Sphingomyelinase Reduces Established Hepatic Fibrosis in Mice.Hepatology research : the official journal of the Japan Society of Hepatology, , More Information

Nojima, Hiroyuki; Freeman, Christopher M; Gulbins, Erich; Lentsch, Alex B (2015. ) Sphingolipids in liver injury, repair and regeneration.Biological chemistry, , 396 (6-7 ) ,633-43 More Information

Wilson, Gregory C; Freeman, Christopher M; Kuethe, Joshua W; Quillin, Ralph C; Nojima, Hiroyuki; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2015. ) CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice.American journal of physiology. Gastrointestinal and liver physiology, , 308 (8 ) ,G702-9 More Information

Jin, Shunying; Merchant, Michael L; Ritzenthaler, Jeffrey D; McLeish, Kenneth R; Lederer, Eleanor D; Torres-Gonzalez, Edilson; Fraig, Mostafa; Barati, Michelle T; Lentsch, Alex B; Roman, Jesse; Klein, Jon B; Rane, Madhavi J (2015. ) Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.PloS one, , 10 (4 ) ,e0121637 More Information

Wilson, Gregory C; Kuboki, Satoshi; Freeman, Christopher M; Nojima, Hiroyuki; Schuster, Rebecca M; Edwards, Michael J; Lentsch, Alex B (2015. ) CXC chemokines function as a rheostat for hepatocyte proliferation and liver regeneration.PloS one, , 10 (3 ) ,e0120092 More Information

Richter, Jillian R; Sutton, Jeffrey M; Belizaire, Ritha M; Friend, Lou Ann; Schuster, Rebecca M; Johannigman, Taylor A; Miller, Steven G; Lentsch, Alex B; Pritts, Timothy A (2014. ) Macrophage-derived chemokine (CCL22) is a novel mediator of lung inflammation following hemorrhage and resuscitation.Shock (Augusta, Ga.), , 42 (6 ) ,525-31 More Information

Yang, Sung; Stepien, David; Hanseman, Dennis; Robinson, Bryce; Goodman, Michael D; Pritts, Timothy A; Caldwell, Charles C; Remick, Daniel G; Lentsch, Alex B (2014. ) Substance P mediates reduced pneumonia rates after traumatic brain injury.Critical care medicine, , 42 (9 ) ,2092-100 More Information

Pewzner-Jung, Yael; Tavakoli Tabazavareh, Shaghayegh; Grassmé, Heike; Becker, Katrin Anne; Japtok, Lukasz; Steinmann, Jörg; Joseph, Tammar; Lang, Stephan; Tuemmler, Burkhard; Schuchman, Edward H; Lentsch, Alex B; Kleuser, Burkhard; Edwards, Michael J; Futerman, Anthony H; Gulbins, Erich (2014. ) Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.EMBO molecular medicine, , 6 (9 ) ,1205-14 More Information

Freeman, Christopher M; Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Johnson, Bobby L; Sutton, Jeffrey M; Schuster, Rebecca M; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2014. ) Characterization of microparticles after hepatic ischemia-reperfusion injury.PloS one, , 9 (5 ) ,e97945 More Information

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , More Information

Nojima, Hiroyuki; Freeman, Christopher M; Schuster, Rebecca M; Japtok, Lukasz; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich; Lentsch, Alex B (2016. ) Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate.Journal of hepatology, , 64 (1 ) ,60-8 More Information

Chang, Alex L; Kim, Young; Seitz, Aaron P; Schuster, Rebecca M; Lentsch, Alex B; Pritts, Timothy A (2017. ) Erythrocyte-Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion.Shock (Augusta, Ga.), , 47 (5 ) ,632-637 More Information

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2017. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , 265 (1 ) ,218-226 More Information

Nojima, Hiroyuki; Konishi, Takanori; Freeman, Christopher M; Schuster, Rebecca M; Japtok, Lukasz; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich; Lentsch, Alex B (2016. ) Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes.PloS one, , 11 (8 ) ,e0161443 More Information

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (03-01-2020. ) Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 318 (3 ) ,G390-G400 More Information

Kim Y.;Goodman M.;Jung A.;Abplanalp W.;Schuster R.;Caldwell C.;Lentsch A.;Pritts T. (01-01-2020. ) Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via.Thrombosis Research, , 185 ,160-166 More Information

Konishi T.;Schuster R.;Lentsch A. (03-01-2019. ) Liver repair and regeneration after ischemia-reperfusion injury is associated with prolonged fibrosi.American Journal of Physiology - Gastrointestinal and Liver Physiology, , 316 (3 ) ,G323-G331 More Information

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (01-01-2019. ) Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American Journal of Physiology - Gastrointestinal and Liver Physiology, , 317 (6 ) ,G773-G783 More Information

Konishi T.;Lentsch A. (10-01-2018. ) Changes in arachidonic acid metabolism during liver ischemia triggers induction of inflammatory inju.Hepatology, , 68 (4 ) ,1642-1643 More Information

Konishi T.;Schuster R.;Lentsch A. (04-01-2018. ) Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and re.American Journal of Physiology - Gastrointestinal and Liver Physiology, , 314 (4 ) ,G471-G482 More Information

Richter J.;Sutton J.;Hexley P.;Johannigman T.;Lentsch A.;Pritts T. (03-01-2018. ) Leukoreduction of packed red blood cells attenuates proinflammatory properties of storage-derived mi.Journal of Surgical Research, , 223 ,128-135 More Information

Kim Y.;Abplanalp W.;Jung A.;Schuster R.;Lentsch A.;Gulbins E.;Caldwell C.;Pritts T. (03-01-2018. ) Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5.Shock, , 49 (3 ) ,288-294 More Information

Konishi T.;Lentsch A. (01-01-2017. ) Hepatic ischemia/reperfusion: Mechanisms of tissue injury, repair, and regeneration.Gene Expression, , 17 (4 ) ,277-287 More Information

Wilson G.;Freeman C.;Nojima H.;Lentsch A. (09-28-2015. ) CXC chemokine receptor signaling in liver repair and regeneration.Signaling Pathways in Liver Diseases: Third Edition, , 166-173 More Information

Freeman C.;Wilson G.;Nojima H.;Lentsch A. (01-01-2015. ) Role of CXC Chemokines in Liver Repair and Regeneration.Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications, , 113-123 More Information

Quillin R.;Wilson G.;Nojima H.;Freeman C.;Wang J.;Schuster R.;Blanchard J.;Edwards M.;Gandhi C.;Gulbins E.;Lentsch A. (01-01-2015. ) Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice.Hepatology Research, , 45 (3 ) ,305-314 More Information

Chatterjee T.K.;Basford J.E.;Knoll E.;Tong W.S.;Blanco V.;Blomkalns A.L.;Rudich S.;Lentsch A.B.;Hui D.Y.;Weintraub N.L. (01-01-2014. ) HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease dur.Diabetes, , 63 (1 ) ,176-187 More Information

Ziobro R.;Henry B.;Lentsch A.;Edwards M.;Riethmüller J.;Gulbins E. (12-01-2013. ) Ceramide in cystic fibrosis.Clinical Lipidology, , 8 (6 ) ,681-691 More Information

Sakai N.;Van Sweringen H.;Belizaire R.;Quillin R.;Schuster R.;Blanchard J.;Burns J.;Tevar A.;Edwards M.;Lentsch A. (01-01-2012. ) Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cell.Journal of Gastroenterology and Hepatology (Australia), , 27 (10 ) ,1609-1616 More Information

Solan P.;Piraino G.;Hake P.;Denenberg A.;O'Connor M.;Lentsch A.;Zingarelli B. (04-01-2011. ) Liver X receptor ? activation with the synthetic ligand T0901317 reduces lung injury and inflammatio.Shock, , 35 (4 ) ,367-374 More Information

Flierl M.;Rittirsch D.;Nadeau B.;Sarma J.;Day D.;Lentsch A.;Huber-Lang M.;Ward P. (02-12-2009. ) Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response.PLoS ONE, , 4 (2 ) , More Information

Shin T.;Kuboki S.;Lentsch A. (05-01-2008. ) Roles of nuclear factor-?B in postischemic liver.Hepatology Research, , 38 (5 ) ,429-440 More Information

Thakar C.V.;Zahedi K.;Revelo M.P.;Wang Z.;Burnham C.E.;Barone S.;Bevans S.;Lentsch A.B.;Rabb H.;Soleimani M. (02-01-2006. ) Erratum: Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney isc .Journal of Clinical Investigation, , 116 (2 ) ,549

Lentsch A. (07-01-2005. ) Activation and function of hepatocyte NF-?B in postischemic liver injury.Hepatology, , 42 (1 ) ,216-218 More Information

Lentsch A. (01-01-2003. ) Proteomics in Practice: A Laboratory Manual of Proteome Analysis.Journal of Investigative Surgery, , 16 (5 ) ,305 More Information

Lentsch A. (12-01-2000. ) Regulation of acute inflammation by the duffy antigen/ receptor for chemokines (darc): exaggerated r .Blood, , 96 (11 PART I ) ,

Lentsch A.;Ward P. (01-01-1999. ) Understanding the pathogenesis of inflammation using rodent models: Identification of a transcriptio.ILAR Journal, , 40 (4 ) ,151-156 More Information

Lentsch A.;Bless N.;Czermak B.;Ward P. (03-20-1998. ) Determinants of NF-?B activation in acute lung injury .FASEB Journal, , 12 (5 ) ,

Lentsch A.;Shanley T.;Ward P. (12-01-1997. ) Interleukin-10 protects against IgG immune complex-induced lung injury through suppression of NF-?B .FASEB Journal, , 11 (3 ) ,

Crouch L.;Lentsch A.;Warner R.;Johnson K.;Ward P. (12-01-1997. ) Regulatory effects of adrenal gland products in IgG immune complex acute lung injury .FASEB Journal, , 11 (3 ) ,

Lentsch A.;Edwards M.;Sims D.;Nakagawa K.;Miller F. (12-01-1996. ) Interleukin-10 inhibits interleukin-2-induced tumor necrosis factor production but does not reduce t .FASEB Journal, , 10 (3 ) ,

Lindberg R.;Slaaf D.;Lentsch A.;Miller F. (01-01-1994. ) Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occ.Microvascular Research, , 47 (2 ) ,203-221 More Information

Pulliam, Kasiemobi E; Joseph, Bernadin; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2021. ) Improving packed red blood cell storage with a high-viscosity buffered storage solution.Surgery, , More Information

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2021. ) Expired But Not Yet Dead: Examining the Red Blood Cell Storage Lesion in Extended-Storage Whole Blood.Shock (Augusta, Ga.), , 55 (4 ) ,526-535 More Information

Pulliam, Kasiemobi E; Joseph, Bernadin; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2021. ) Washing packed red blood cells decreases red blood cell storage lesion formation.Surgery, , 169 (3 ) ,666-670 More Information

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2020. ) Save it-don't waste it! Maximizing utilization of erythrocytes from previously stored whole blood.The journal of trauma and acute care surgery, , 89 (4 ) ,665-672 More Information

Jung, Andrew D; Friend, Lou Ann; Stevens-Topie, Sabre; Schuster, Rebecca; Lentsch, Alex B; Gavitt, Brian; Caldwell, Charles C; Pritts, Timothy A (2020. ) Direct Peritoneal Resuscitation Improves Survival in a Murine Model of Combined Hemorrhage and Burn Injury.Military medicine, , 185 (9-10 ) ,e1528-e1535 More Information

Beckmann, Nadine; Sutton, Jeffrey M; Hoehn, Richard S; Jernigan, Peter L; Friend, Lou Ann; Johanningman, Taylor A; Schuster, Rebecca M; Lentsch, Alex B; Caldwell, Charles C; Pritts, Timothy A (2020. ) IFN? and TNF? mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation.American journal of physiology. Lung cellular and molecular physiology, , 318 (5 ) ,L864-L872 More Information

Keywords

inflammation, sepsis, trauma, liver injury, cytokines, leukocytes

Other Information

Division of Research,

Contact Information

Academic - CARE/Crawley Building
Room E870
Cincinnati  Ohio, 45267
Phone: 513-558-0175
Fax: 513-558-3513
alex.lentsch@uc.edu