Michael Lieberman

Michael A Lieberman , PhD

Professor

Office 2253 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267
Phone (513)558-5645
Email michael.lieberman@uc.edu

Education

Bachelor's Degree: Massachusetts Institute of Technology Cambridge, MA, 1972 (Biology)

Doctoral Degree: Brandeis University Waltham, MA, 1978 (Biochemistry)

Postdoctoral Fellowship: Washington University St. Louis, MO, 1980

Research and Practice Interests

My research interests are as follows:analysis of megakaryocyte differentiation is being investigated using cultured mammalian cells as a model system;introduction of dominant negative mutations of proteins known to be important in signal transduction is being carried out, as are alternative means of inducing differentiation in these cells.

Positions and Work Experience

1981 -1983 Assistant Professor, Worked on membrane regulation of cell proliferation in my first independent position., Harvard School of Public Health, Boston, MA

1983 -1995 Associate Professor, Worked on cell growth regulation, megakaryocyte differentiation, and the teaching of graduate and medical students in biochemistry., University of Cincinnati College of Medicine, Cincinnati, OH

1995 -2002 Professor, University of Cincinnati College of Medicine, Cincinnati, OH

2002 - Distinguished Teaching Professor, Continuing teaching and writing textbooks for medical students., University of Cincinnati College of Medicine, Cincinnati, OH

2003 -2012 Dean, Instructional and Research Computing, Worked for UCIT, in charge of Instructional Computing through the central IT provider at the University of Cincinnati., University of Cincinnati, Cincinnati, OH

2009 -2012 Interim VP & CIO, Held the interim CIO position for UCIT at the University of Cincinnati, and was responsible for all central computing at the University., University of Cincinnati, Cincinnati, OH

Publications

Peer Reviewed Publications

Groden, J; Lieberman, M A (2001. ) Overview of genetics for the clinician. Epilepsia, , 42 Suppl 5 ,2-10

Jawa, R S; Quaid, G A; Williams, M A; Cave, C M; Robinson, C T; Babcock, G F; Lieberman, M A; Witt, D; Solomkin, J S (1999. ) Tumor necrosis factor alpha regulates CXC chemokine receptor expression and function. Shock (Augusta, Ga.), , 11 (6 ) ,385-90

Denko, N; Langland, R; Barton, M; Lieberman, M A (1997. ) Uncoupling of S-phase and mitosis by recombinant cytotoxic necrotizing factor 2 (CNF2).Experimental cell research, , 234 (1 ) ,132-8 More Information

Hudson, K M; Denko, N C; Schwab, E; Oswald, E; Weiss, A; Lieberman, M A (1996. ) Megakaryocytic cell line-specific hyperploidy by cytotoxic necrotizing factor bacterial toxins. Blood, , 88 (9 ) ,3465-73

Borges, L G; Seifert, R A; Grant, F J; Hart, C E; Disteche, C M; Edelhoff, S; Solca, F F; Lieberman, M A; Lindner, V; Fischer, E H; Lok, S; Bowen-Pope, D F (1996. ) Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells. Circulation research, , 79 (3 ) ,570-80

Tiao, ; Hudson, ; Lieberman, ; Fischer, ; Hasselgren, (1996. ) Identification of Altered Gene Expression in Skeletal Muscle during Sepsis Using Differential Display .The Journal of surgical research, , 64 (1 ) ,63-7

Tiao, G M; Hudson, K; Lieberman, M A; Fischer, J E; Hasselgren, P O (1996. ) Identification of altered gene expression in skeletal muscle during sepsis using differential display.The Journal of surgical research, , 64 (1 ) ,63-7 More Information

Sandrock, B; Hudson, K M; Williams, D E; Lieberman, M A (1996. ) Cytokine production by a megakaryocytic cell line. In vitro cellular & developmental biology. Animal, , 32 (4 ) ,225-33

Herman, Jerome H.; O'Connor, Michael P.; Lieberman, Michael A. (1996. ) Perturbation of a Cartilage Autocrine/Paracrine Basic Fibroblast Growth Factor Metabolic Regulatory Network by Osteoarthritic Synovial Tissue. American journal of therapeutics, , 3 (1 ) ,52-62

Tiao, G; Noguchi, Y; Lieberman, M A; Fischer, J E; Hasselgren, P O (1995. ) Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA. Shock (Augusta, Ga.), , 4 (6 ) ,403-10

Kiffmeyer, W R; Stambrook, P J; Lieberman, M A (1994. ) Retroviral mediated gene transfer in megakaryocytic cell lines. In vitro cellular & developmental biology. Animal, , 30A (11 ) ,803-9

Namciu, S; Lieberman, M A; Stavnezer, E (1994. ) Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation. Oncogene, , 9 (5 ) ,1407-16

Armstrong, E; Korhonen, J; Silvennoinen, O; Cleveland, J L; Lieberman, M A; Alitalo, R (1993. ) Expression of tie receptor tyrosine kinase in leukemia cell lines. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, , 7 (10 ) ,1585-91

Jones, C L; Witte, D P; Feller, M J; Fugman, D A; Dorn, G W; Lieberman, M A (1992. ) Response of a human megakaryocytic cell line to thrombin: increase in intracellular free calcium and mitogen release. Biochimica et biophysica acta, , 1136 (3 ) ,272-82

Liu, H S; Scrable, H; Villaret, D B; Lieberman, M A; Stambrook, P J (1992. ) Control of Ha-ras-mediated mammalian cell transformation by Escherichia coli regulatory elements. Cancer research, , 52 (4 ) ,983-9

Nagasaki, T; Lieberman, M A (1991. ) Potentiation of the activity of mouse liver-derived HBGF-1-like growth factor by heparin and dithiothreitol: evidence for the involvement of a plasma factor. Biochimica et biophysica acta, , 1094 (3 ) ,330-8

Nagasaki, T; Lieberman, M A (1991. ) Liver contains heparin-binding growth factors as the major growth factor for cultured fibroblasts. Hepatology (Baltimore, Md.), , 13 (1 ) ,6-14

Fugman, D A; Witte, D P; Jones, C L; Aronow, B J; Lieberman, M A (1990. ) In vitro establishment and characterization of a human megakaryoblastic cell line. Blood, , 75 (6 ) ,1252-61

Ratner, N; Lieberman, M A; Riccardi, V M; Hong, D M (1990. ) Mitogen accumulation in von Recklinghausen neurofibromatosis.Annals of neurology, , 27 (3 ) ,298-303 More Information

Witte, D P; Nagasaki, T; Stambrook, P; Lieberman, M A (1989. ) Identification of an acidic fibroblast growth factor-like activity in a mesoblastic nephroma. Laboratory investigation; a journal of technical methods and pathology, , 60 (3 ) ,353-9

Witte, D P; Stambrook, P J; Feliciano, E; Jones, C L; Lieberman, M A (1988. ) Growth factor production by a human megakaryocytic tumor cell line.Journal of cellular physiology, , 137 (1 ) ,86-94 More Information

Ratner, N; Hong, D M; Lieberman, M A; Bunge, R P; Glaser, L (1988. ) The neuronal cell-surface molecule mitogenic for Schwann cells is a heparin-binding protein. Proceedings of the National Academy of Sciences of the United States of America, , 85 (18 ) ,6992-6

Nagasaki, T; Lieberman, M A (1987. ) Heparin potentiates the action of plasma membrane-associated growth stimulatory activity.Journal of cellular physiology, , 133 (2 ) ,365-71 More Information

Whitsett, J A; Weaver, T E; Lieberman, M A; Clark, J C; Daugherty, C (1987. ) Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung. The Journal of biological chemistry, , 262 (16 ) ,7908-13

Nagasaki, T; Lieberman, M A (1987. ) Growth-stimulatory action of plasma membrane-associated growth factor. A synergistic effect with platelet-poor plasma. Experimental cell research, , 170 (1 ) ,170-4

Grupp, S A; Lieberman, M A; Harmony, J A (1985. ) Inhibition of lymphocyte proliferation by detergent-solubilized mouse liver membranes. The Journal of cell biology, , 101 (2 ) ,380-5

Lieberman, M A (1984. ) The presence of both growth inhibitory and growth stimulatory factors on membranes prepared from mouse liver. Biochemical and biophysical research communications, , 120 (3 ) ,891-7

Lieberman, M A (1983. ) Mitogenic proteins of the 3T3 plasma membrane.Journal of cellular physiology, , 114 (1 ) ,73-6 More Information

Lieberman, M A; Keller-McGandy, C E; Woolsey, T A; Glaser, L (1982. ) Binding of isolated 3T3 surface membranes to growing 3T3 cells and their effect on cell growth.Journal of cellular biochemistry, , 20 (1 ) ,81-93 More Information

Raben, D; Lieberman, M A; Glaser, L (1981. ) Growth inhibitory protein(s) in the 3T3 cell plasma membrane. Partial purification and dissociation of growth inhibitory events from inhibition of amino acid transport.Journal of cellular physiology, , 108 (1 ) ,35-45 More Information

Lieberman, M A; Raben, D; Glaser, L (1981. ) Cell surface-associated growth inhibitory proteins. Experimental cell research, , 133 (2 ) ,413-9

Lieberman, M A; Deuel, T F; Glaser, L (1981. ) Increased epidermal growth factor binding to Go-arrested 3T3 cells. FEBS letters, , 126 (1 ) ,45-8

Lieberman, M A; Glaser, L (1981. ) Density-dependent regulation of cell growth: an example of a cell-cell recognition phenomenon. The Journal of membrane biology, , 63 (1-2 ) ,1-11

Lieberman, M A; Rothenberg, P; Raben, D M; Glaser, L (1980. ) Effect of 3T3 plasma membranes on cells exposed to epidermal growth factor. Biochemical and biophysical research communications, , 92 (2 ) ,696-702

Lieberman, M A; Raben, D M; Whittenberger, B; Glaser, L (1979. ) Effect of plasma membranes on solute transport in 3T3 cells. The Journal of biological chemistry, , 254 (14 ) ,6357-61

Hong, J S; Hunt, A G; Masters, P S; Lieberman, M A (1979. ) Requirements of acetyl phosphate for the binding protein-dependent transport systems in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, , 76 (3 ) ,1213-7

Whittenberger, B; Raben, D; Lieberman, M A; Glaser, L (1978. ) Inhibition of growth of 3T3 cells by extract of surface membranes. Proceedings of the National Academy of Sciences of the United States of America, , 75 (11 ) ,5457-61

Lieberman, M A; Simon, M; Hong, J S (1977. ) Characterization of Escherichia coli mutant incapable of maintaining a transmembrane potential. MetC ecfts mutations. The Journal of biological chemistry, , 252 (12 ) ,4056-67

Hong, J S; Haggerty, D L; Lieberman, M A (1977. ) Energy coupling factor as target of colicin K: characterization of a colicin K-insensitive ecf mutant of Escherichia coli. Antimicrobial agents and chemotherapy, , 11 (5 ) ,881-7

Lieberman, M A; Hong, J S (1976. ) Changes in active transport, intracellular adenosine 5'-triphosphate levels, macromolecular syntheses, and glycolysis in an energy-uncoupled mutant of Escherichia coli. Journal of bacteriology, , 125 (3 ) ,1024-31

Lieberman, M A; Hong, J S (1976. ) Energization of osmotic shock-sensitive transport systems in Escherichia coli requires more than ATP. Archives of biochemistry and biophysics, , 172 (1 ) ,312-5

Lieberman, M A; Hong, J S (1974. ) A mutant of Escherichia coli defective in the coupling of metabolic energy to active transport. Proceedings of the National Academy of Sciences of the United States of America, , 71 (11 ) ,4395-9

Platt, Mark D; Schurr, Michael J; Sauer, Karin; Vazquez, Gustavo; Kukavica-Ibrulj, Irena; Potvin, Eric; Levesque, Roger C; Fedynak, Amber; Brinkman, Fiona S L; Schurr, Jill; Hwang, Sung-Hei; Lau, Gee W; Limbach, Patrick A; Rowe, John J; Lieberman, Michael A; Barraud, Nicolas; Webb, Jeremy; Kjelleberg, Staffan; Hunt, Donald F; Hassett, Daniel J (2008. ) Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions.Journal of bacteriology, , 190 (8 ) ,2739-58 More Information

Brehm, B J; Summer, S S; Khoury, J C; Filak, A T; Lieberman, M A; Heubi, J E Health Status and Lifestyle Habits of US Medical Students: A Longitudinal Study.Annals of medical and health sciences research, , 6 (6 ) ,341-347 More Information

Tiao, G; Lieberman, M; Fischer, J E; Hasselgren, P O (1997. ) Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. The American journal of physiology, , 272 (3 Pt 2 ) ,R849-56

Tiao, G; Fagan, J; Roegner, V; Lieberman, M; Wang, J J; Fischer, J E; Hasselgren, P O (1996. ) Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.The Journal of clinical investigation, , 97 (2 ) ,339-48 More Information

Tiao, G; Fagan, J M; Samuels, N; James, J H; Hudson, K; Lieberman, M; Fischer, J E; Hasselgren, P O (1994. ) Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.The Journal of clinical investigation, , 94 (6 ) ,2255-64 More Information

Bunge, R; Glaser, L; Lieberman, M; Raben, D; Salzer, J; Whittenberger, B; Woolsey, T (1979. ) Growth control by cell to cell contact.Journal of supramolecular structure, , 11 (2 ) ,175-87 More Information

Published Books

Smith, C., Marks, A. and Lieberman, MA (2004. ) Marks Basic Medical Biochemistry, a Clinical Approach .Philadelphia, PA , Lippincott, Williams & Wilkins (Co-Author)

Lieberman, MA, Marks, A, and Smith, C. (2006. ) Marks' Essentials of Medical Biochemistry, a Clinical Approach .Philadelphia, PA , Lippincott, Williams & Wilkins (Co-Author)

Lieberman, MA and Marks, A. (2008. ) Marks Basic Medical Biochemistry, a Clinical Approach, 3rd edition .Philadelphia, PA , Lippincott, Williams & Wilkins (Author)

Lieberman, MA and Ricer, R. (2009. ) Lippincott's Illustrated Q&A Review of Biochemistry .Philadelphia, PA , Lippincott, Williams & Wilkins (Author)

Lieberman, MA, Marks, A, and Peet, A. (2012. ) Marks Basic Medical Biochemistry, a Clinical Approach, 4th edition .Philadelphia, PA , Lippincott, Williams & Wilkins (Author)

Lieberman, MA and Ricer, R. (2013. ) BRS Biochemistry, Molecular Biology, and Genetics .Philadelphia, PA , Lippincott, Williams & Wilkins (Co-Author)

Lieberman, MA and Peet, A. (2015. ) Marks Essentials of Medical Biochemistry, second edition .Baltimore, MD, USA , Wolter-Kluwers

Lieberman MA and Peet A. (2017. ) Marks Basic Medical Biochemistry, A Clinical Approach, 5th edition .Philadelphia , Wolters Kluwer (Author)

Keywords

Biochemist,Cell Biologist,Protein Purification,Membrane,Amino Acid Transport,Growth and Reproduction,Receptor,Surface Properties,Cell Surface Receptor

Contact Information

Academic - Office 2253 Medical Sciences Building
231 Albert Sabin Way
CincinnatiĀ  Ohio, 45267
Phone: (513)558-5645
michael.lieberman@uc.edu