Chia-Ying Lin

Chia-Ying James Lin

Mary S. and Joseph S. Stern Jr. Professor in Musculoskeletal Research

Medical Sciences Building

5452

COM Orthopaedic Surgery - 0212

5452 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267-0212

Education

B.S., National Taiwan University Taipei, Taiwan, 1997 (Civil Engineering)

M.S., University of Michigan Ann Arbor, Mich., 2002 (Biomedical Engineering)

Ph.D., University of Michigan Ann Arbor, Mich., 2004 (Biomechanics/Tissue Engineering, Biomedical Engineering)

Research Support

Grant: #R21EB025378 09-25-2017 -07-31-2019 NIH/National Institute of Biomedical Imaging and Bioengineering Development of Hybrid Tracheas for Long-Segment Tracheal Reconstruction Role:PI $446,324.00 Active Type:Grant

Grant: #R01NS103992 NIH/NINDS A novel smart patch for the fetoscopic procedure to repair spina fbifida Role:Co-PI $2,324,878 Active Type:Grant

Grant: #Center for Technology Commercialization 2017 Innovation Award 09-01-2017 -08-31-2018 Cincinnati Children’s Hospital Medical Center Shape-memory patch for prenatal spina bifida repair by fetoscopic approach Role:Co-PI $100,000 Completed Type:Grant

Grant: #Pilot Translational Research and Innovative Core Grant 07-01-2017 -06-30-2018 Center for Clinical & Translation Science & Training (sponsored by NIH Roadmap CTSA) Injectable gel depot of simvastatin beta-hydroxy acid to treat discogenic low back pain - IND enabling phase Role:PI $60,000 Completed Type:Grant

Grant: #2017 Angela S.M. Kuo Memorial Award 06-01-2017 -05-31-2019 Pediatric Orthopedic Society of North America A Novel Treatment for Large Osteochondral Defects Role:Co-PI $30,000 Active Type:Grant

05-01-2017 -04-30-2018 Depuy Synthes Incidence of Stress Shielding with the Attune TKA Role:PI $43,974 Completed Type:Contract

Grant: #Focused Grant Award 01-01-2017 -12-31-2017 American Sleep Medicine Foundation Custom 3-D Printed Non-invasive Ventilation Mask for Children with Obstructive Sleep Apnea Role:Co-Investigator $20,000 Completed Type:Grant

Grant: #Orthopaedic Faculty Grant Investigators:Grawe and Lin 01-01-2017 -12-31-2017 University of Cincinnati Department of Orthopaedic Surgery Simvastatin Acid Used in Meniscal Tear Repair Role:Co-PI $15,000 Completed Type:Grant

Grant: #Orthopaedic Faculty Grant Investigators:Archdeacon and Lin 01-01-2017 -12-31-2017 University of Cincinnati Department of Orthopaedic Surgery Application of Ground Penetrating Radar for Pelvic Fracture Detection Role:Co-PI $15,000 Completed Type:Grant

Grant: #Technology Accelerator Award Investigators:Lin, Chia-Ying 07-01-2016 -06-30-2017 University of Cincinnati Department of Orthopaedic Surgery Injectable gel depot of simvastatin beta hydroxy acid to treat discogenic low back pain Role:PI $40,000 Completed Type:Grant

Grant: #R01AR060892 Investigators:Hollister, La Marca, and Lin 09-17-2011 -08-31-2017 NIH/NIAMS Integrated Structural BMP-2 Carrier Systems for Cervical Spine Fusio Role:Co-Investigator $2,437,852 Completed Type:Grant

Grant: #University of Cincinnati Cancer Institute Research Pilot Grant Investigators:Czyzyk-Krzeska, Archdeacon, and Lin 08-01-2015 -07-31-2016 University of Cincinnati Cancer Institute Mechanisms of bone metastases in renal cancer Role:Co-PI $40,000 Completed Type:Grant

Grant: #R01AR056649 06-11-2010 -03-31-2015 NIH/NIAMS Simvastatin to Retard Degenerative Disc Disease Role:PI $1,326,998 Completed Type:Grant

Grant: #R21NS055731 05-24-2006 -04-30-2009 NIH/NINDS Designed Degradable Interbody Cages Role:PI $344,512 Completed Type:Grant

Grant: #R01NS103992 Investigators:Lin, Chia-Ying 04-01-2019 -03-31-2024 National Institute of Neurological Disorders and Stroke A novel smart patch for the fetoscopic procedure to repair spina bifida Role:PI $495,775.00 Awarded Level:Federal

Grant: #2019 J.R. Neff Award Investigators:Lin, Chia-Ying 08-01-2019 -07-31-2022 Musculoskeletal Transplant Foundation Novel Process for 3D Printing with Decellurized Extracellular Matrix for Tissue Regeneration Role:PI $300,000.00 Awarded Level:Private Non-Profit

Grant: #W81XWH-19-2-0029 Investigators:Braley, Susan; Branam, Barton; Colosimo, Angelo; Glogovac, Georgina; Grawe, Brian; Lin, Chia-Ying; Utz, Christopher; Zhiva, Ergent 09-30-2019 -09-29-2023 Department of the Army Medical Research Acquisition Activity Sustained Delivery of Simvastatin to Augment Meniscal Healing: Is Regenerative Healing Possible? Role:Collaborator $1,973,671.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi D; Lin, Chia-Ying (2015. ) BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.Journal of cancer research and clinical oncology, , 141 (6 ) ,1013-24

Than, Khoi D; Rahman, Shayan U; Wang, Lin; Khan, Adam; Kyere, Kwaku A; Than, Tracey T; Miyata, Yoshinari; Park, Yoon-Shin; La Marca, Frank; Kim, Hyungjin M; Zhang, Huina; Park, Paul; Lin, Chia-Ying (2014. ) Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.The spine journal : official journal of the North American Spine Society, , 14 (6 ) ,1017-28

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying (2013. ) Bone formation induced by BMP-2 in human osteosarcoma cells.International journal of oncology, , 43 (4 ) ,1095-102

Park, Yoon Shin; David, Allan E; Park, Kyung Min; Lin, Chia-Ying; Than, Khoi D; Lee, Kyuri; Park, Jun Beom; Jo, Inho; Park, Ki Dong; Yang, Victor C (2013. ) Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.The AAPS journal, , 15 (2 ) ,367-76

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying (2012. ) BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.International journal of cancer, , 131 (8 ) ,1941-50

Wang, Lin; Rahman, Shayan; Lin, Chia-Ying; Valdivia, Juan; Than, Khoi; La Marca, Frank; Park, Paul (2012. ) A novel murine model of human renal cell carcinoma spinal metastasis.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , 19 (6 ) ,881-3

Park, Jun-Beom; Zhang, Huina; Lin, Chia-Ying; Chung, Chong Pyoung; Byun, Youngro; Park, Yoon Shin; Yang, Victor C (2012. ) Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors ?.The Journal of surgical research, , 174 (2 ) ,278-83

Than, Khoi D; Rahman, Shayan U; Vanaman, Monique J; Wang, Anthony C; Lin, Chia-Ying; Zhang, Huina; La Marca, Frank; Park, Paul (2012. ) Bone morphogenetic proteins and degenerative disk disease.Neurosurgery, , 70 (4 ) ,996-1002; discussion

Zhang, Huina; Yang, Sushan; Wang, Lin; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying (2011. ) Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation.Journal of neurosurgery. Spine, , 15 (4 ) ,404-13

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Valdivia, Juan; Lin, Chia-Ying (2011. ) BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer biology & therapy, , 11 (5 ) ,457-63

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Lin, Chia-Ying (2011. ) Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity.International journal of cancer, , 128 (2 ) ,294-303

Lin, Chia-Ying; Wang, Lin; Than, Khoi; Marca, Frank La; Park, Paul (2010. ) Cancer stem cell markers: what is their diagnostic value?.Expert opinion on medical diagnostics, , 4 (6 ) ,473-81

Zhang, Huina; Migneco, Francesco; Lin, Chia-Ying; Hollister, Scott J (2010. ) Chemically-conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells.Tissue engineering. Part A, , 16 (11 ) ,3441-8

Kang, Heesuk; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying (2010. ) Analysis of load sharing on uncovertebral and facet joints at the C5-6 level with implantation of the Bryan, Prestige LP, or ProDisc-C cervical disc prosthesis: an in vivo image-based finite element study.Neurosurgical focus, , 28 (6 ) ,E9

Thawani, Jayesh P; Wang, Anthony C; Than, Khoi D; Lin, Chia-Ying; La Marca, Frank; Park, Paul (2010. ) Bone morphogenetic proteins and cancer: review of the literature.Neurosurgery, , 66 (2 ) ,233-46; discussion 2

Zhang, Huina; Lin, Chia-Ying; Hollister, Scott J (2009. ) The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds.Biomaterials, , 30 (25 ) ,4063-9

Lin, Chia-Ying; Kang, Heesuk; Rouleau, Jeffrey P; Hollister, Scott J; Marca, Frank La (2009. ) Stress analysis of the interface between cervical vertebrae end plates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses: an in vivo image-based finite element study.Spine, , 34 (15 ) ,1554-60

Zhang, Huina; La Marca, Frank; Hollister, Scott J; Goldstein, Steven A; Lin, Chia-Ying (2009. ) Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture.Journal of neurosurgery. Spine, , 10 (6 ) ,522-30

Wang, Lin; Park, Paul; Lin, Chia-Ying (2009. ) Characterization of stem cell attributes in human osteosarcoma cell lines.Cancer biology & therapy, , 8 (6 ) ,543-52

Zhang, Huina; Wang, Lin; Park, Jun Beom; Park, Paul; Yang, Victor C; Hollister, Scott J; La Marca, Frank; Lin, Chia-Ying (2009. ) Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury.Arthritis research & therapy, , 11 (6 ) ,R172

Zhang, Huina; Lin, Chia-Ying (2008. ) Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway.Spine, , 33 (16 ) ,E525-31

Lin, Chia-Ying; Wirtz, Tobias; LaMarca, Frank; Hollister, Scott J (2007. ) Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process.Journal of biomedical materials research. Part A, , 83 (2 ) ,272-9

Lin, Chia-Ying; Schek, Rachel M; Mistry, Amit S; Shi, Xinfeng; Mikos, Antonios G; Krebsbach, Paul H; Hollister, Scott J Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds.Tissue engineering, , 11 (9-10 ) ,1589-98

Hollister, S J; Lin, C Y; Saito, E; Lin, C Y; Schek, R D; Taboas, J M; Williams, J M; Partee, B; Flanagan, C L; Diggs, A; Wilke, E N; Van Lenthe, G H; Müller, R; Wirtz, T; Das, S; Feinberg, S E; Krebsbach, P H (2005. ) Engineering craniofacial scaffolds.Orthodontics & craniofacial research, , 8 (3 ) ,162-73

Lin, Chia-Ying; Hsiao, Chun-Ching; Chen, Po-Quan; Hollister, Scott J (2004. ) Interbody fusion cage design using integrated global layout and local microstructure topology optimization. Spine, , 29 (16 ) ,1747-54

Hollister, Scott J; Lin, Chia-Ying; Lin, Cheng-Yu; Schek, Rachel D; Taboas, Juan M; Flanagan, Colleen L; Saito, Eiji; Williams, Jessica M; Das, Suman; Wirtz, Tobias; Krebsbach, Paul H (2004. ) Design and fabrication of scaffolds for anatomic bone reconstruction. The Medical journal of Malaysia, , 59 Suppl B ,131-2

Kang, Heesuk; Hollister, Scott J; La Marca, Frank; Park, Paul; Lin, Chia-Ying (2013. ) Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering.Journal of biomechanical engineering, , 135 (10 ) ,101013-8

Huang, Chun-Hsiung; Liau, Jiann-Jong; Ho, Fang-Yuan; Lin, Chia-Yin; Young, Tai-Horng; Cheng, Cheng-Kung (2005. ) Polyethylene failure of the patellar component in New Jersey low-contact stress total knee arthroplasties. The Journal of arthroplasty, , 20 (2 ) ,202-8

Ghosh, Paulomi; Gruber, Stacey M S; Lin, Chia-Ying; Whitlock, Patrick W (2018. ) Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold.Biofabrication, , 10 (2 ) ,025007

Ma, Jun; He, Yunfei; Liu, Xilin; Chen, Weiming; Wang, An; Lin, Chia-Ying; Mo, Xiumei; Ye, Xiaojian (2018. ) A novel electrospun-aligned nanoyarn/three-dimensional porous nanofibrous hybrid scaffold for annulus fibrosus tissue engineering.International journal of nanomedicine, , 13 ,1553-1567

Ni, Yikun; Wang, Lizhen; Liu, Xiaoyu; Zhang, Hongquan; Lin, Chia-Ying; Fan, Yubo (2017. ) Micro-mechanical properties of different sites on woodpecker's skull.Computer methods in biomechanics and biomedical engineering, , 20 (14 ) ,1483-1493

Ghosh, Paulomi; Gruber, Stacey M S; Lin, Chia-Ying; Whitlock, Patrick (2018. ) Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold.Biofabrication, ,

Oria, Marc; Tatu, Rigwed R; Lin, Chia-Ying; Peiro, Jose L (2019. ) In Vivo Evaluation of Novel PLA/PCL Polymeric Patch in Rats for Potential Spina Bifida Coverage.The Journal of surgical research, , 242 ,62-69

Tatu, Rigwed; Oria, Marc; Pulliam, Sarah; Signey, Lorenzo; Rao, Marepalli B; Peiro, Jose L; Lin, Chia-Ying (2019. ) Using poly(l-lactic acid) and poly(?-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair.Journal of biomedical materials research. Part B, Applied biomaterials, , 107 (2 ) ,295-305

Gruber, Stacey M S; Ghosh, Paulomi; Mueller, Karl Wilhelm; Whitlock, Patrick W; Lin, Chia-Ying (2019. ) Novel Process for 3D Printing Decellularized Matrices.Journal of visualized experiments : JoVE, , (143 ) ,

Nguyen, Khoi; Pan, Hsuan-Yeh; Haworth, Kevin; Mahoney, Eric; Mercado-Shekhar, Karla P; Lin, Chia-Ying; Zhang, Zhe; C Park, Yoonjee (2019. ) Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.Ultrasound in medicine & biology, , 45 (1 ) ,160-169

Xiong, Qisheng; Wang, Xuesong; Wang, Lizhen; Huang, Yan; Tian, Xiaodong; Fan, Yubo; Lin, Chia-Ying (2018. ) BMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model.OncoTargets and therapy, , 11 ,7543-7553

Wang, Lizhen; Lin, Chia-Ying; Yao, Wei; Wong, Duo Wai-Chi; Zhu, Rui (2018. ) Biomechanics and Bioengineering of Orthopedic and Cardiovascular Rehabilitation.Journal of healthcare engineering, , 2018 ,1716809

Lin, Chia-Ying (2012. ) Comment. Neurosurgery, , 71 (1 ) ,125

Tatu R.;Lin C. (01-01-2018. ) Chapter 2: Characterization of biomaterial patches as fetal surgery implants .Frontiers in Nanobiomedical Research, , 10 ,29-47

Wang L.;Lin C.Y.;Yao W.;Wong D.W.C.;Zhu R. (01-01-2018. ) Biomechanics and Bioengineering of Orthopedic and Cardiovascular Rehabilitation.Journal of Healthcare Engineering, , 2018 ,

Xiong Q.;Wang X.;Wang L.;Huang Y.;Tian X.;Fan Y.;Lin C.Y. (01-01-2018. ) BMP-2 inhibits lung metastasis of osteosarcoma: An early investigation using an orthotopic model.OncoTargets and Therapy, , 11 ,7543-7553

Tatu R.;Lin C. (01-01-2017. ) Characterization of biomaterial patches as fetal surgery implants.Tissue Engineering and Nanotheranostics, , 29-48

Lin C. (07-01-2012. ) Role of cancer stem cells in spine tumors: Review of current literature: Commentary.Neurosurgery, , 71 (1 ) ,125

Lin C.;Wang L.;Than K.;Marca F.;Park P. (11-01-2010. ) Cancer stem cell markers: What is their diagnostic value?.Expert Opinion on Medical Diagnostics, , 4 (6 ) ,473-481

Kang H.;Lin C.;Hollister S. (10-01-2010. ) Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed .Structural and Multidisciplinary Optimization, , 42 (4 ) ,633-644

Hollister S.J.;Lin C.Y.;Kang H.;Adachi T. (12-01-2008. ) Computational design and simulation of tissue engineering scaffolds.Virtual Prototyping and Bio Manufacturing in Medical Applications, , 113-127

Wong D.Y.;Liao E.E.;Leveque J.C.;Brumblay H.;Lin C.Y.;Lamarca F.;Krebsbach P.H.;Hollister S.J. (12-01-2008. ) Engineered scaffold architecture influences soft tissue regeneration.Bio-Materials and Prototyping Applications in Medicine, , 67-78

Hollister S.J.;Lin C.Y.;Lin C.Y. (12-01-2006. ) Image-based hierarchical analysis and design of tissue engineering scaffolds.Mechanics of Biological Tissue, , 503-515

Jongpaiboonkit L.;Lin C.Y.;Krebsbach P.H.;Hollister S.J.;Halloran J.W. (04-04-2006. ) Mechanical behavior of complex 3D calcium phosphate cement scaffolds fabricated by indirect solid fr .Key Engineering Materials, , 309-311 II ,957-960

Hollister S.;Lin C.;Saito E.;Lin C.;Schek R.;Taboas J.;Williams J.;Partee B.;Flanagan C.;Diggs A.;Wilke E.;Van Lenthe G.;Müller R.;Wirtz T.;Das S.;Feinberg S.;Krebsbach P. (12-01-2005. ) Engineering craniofacial scaffolds.Orthodontics and Craniofacial Research, , 8 (3 ) ,162-173

Contact Information

Academic - 5452 Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0212
Phone: (513)558-8412
Fax: (513)558-2220
chia-ying.lin@uc.edu