Michael Linke

Michael J Linke , PhD

Adjunct Professor

Cincinnati Department of Veteran Affairs Medical Center
3200 Vine Street
Cincinnati, Ohio 45220
Phone 513-861-3100
Fax 513-475-6415
Email Michael.Linke@va.gov

Education

Bachelor's Degree: St. Joseph's College 1981 (Biology)

Master's Degree: St. Thomas Institute 1983 (Biology and Experimental Medicine)

Doctoral Degree: University of Cincinnati 1993 (Pathology and Laboratory medicine)

Fellowship: Children's Hospital Research Foundation 1995 (Pulmonary Biology)

Research and Practice Interests

Pneumocystis

Research Support

Grant: #153185.5121205.0413/Ul1TR002541 Investigators:Linke, Michael 05-15-2021 -04-30-2023 National Center for Advancing Translational Sciences SMART IRB Ambassadors - The Harvard Clinical and Translational Science Center Role:PI 70031.00 Hold Level:Federal

Publications

Peer Reviewed Publications

Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T (2013. ) Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia.Infection and immunity, , 81 (3 ) ,984-95 More Information

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D (2010. ) Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.PloS one, , 5 (1 ) ,e8524 More Information

Linke, Michael J; Ashbaugh, Alan D; Demland, Jeffery A; Walzer, Peter D (2009. ) Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure.Respiratory research, , 10 ,10 More Information

Cushion, Melanie T; Collins, Margaret S; Linke, Michael J (2009. ) Biofilm formation by Pneumocystis spp.Eukaryotic cell, , 8 (2 ) ,197-206 More Information

Linke, Michael J; Ashbaugh, Alan A; Koch, Judith V; Levin, Linda; Tanaka, Reiko; Walzer, Peter D Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice.The Journal of eukaryotic microbiology, , 56 (1 ) ,58-65 More Information

Motz, Gregory T; Eppert, Bryan L; Sun, Guangyun; Wesselkamper, Scott C; Linke, Michael J; Deka, Ranjan; Borchers, Michael T (2008. ) Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. Journal of immunology (Baltimore, Md. : 1950), , 181 (11 ) ,8036-43

Koneti, Adi; Linke, Michael J; Brummer, Elmer; Stevens, David A (2008. ) Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis.Infection and immunity, , 76 (3 ) ,994-1002 More Information

Keely, Scott P; Linke, Michael J; Cushion, Melanie T; Stringer, James R (2007. ) Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription.Fungal genetics and biology : FG & B, , 44 (9 ) ,905-19 More Information

Lekkala, Madhavi; LeVine, Ann Marie; Linke, Michael J; Crouch, Erika C; Linders, Bruce; Brummer, Elmer; Stevens, David A (2006. ) Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D.Infection and immunity, , 74 (8 ) ,4549-56 More Information

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter (2006. ) Efficient resolution of Pneumocystis murina infection in surfactant protein A-deficient mice following withdrawal of corticosteroid-induced immunosuppression.Journal of medical microbiology, , 55 (Pt 2 ) ,143-7 More Information

Linke, Michael; Ashbaugh, Alan; Demland, Jeffery; Koch, Judith; Tanaka, Reiko; Walzer, Peter (2006. ) Resolution of Pneumocystis murina infection following withdrawal of corticosteroid induced immunosuppression.Microbial pathogenesis, , 40 (1 ) ,15-22 More Information

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M (2005. ) Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, , 2 (2 ) ,149-55

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter (2005. ) Surfactant protein A limits Pneumocystis murina infection in immunosuppressed C3H/HeN mice and modulates host response during infection.Microbes and infection / Institut Pasteur, , 7 (4 ) ,748-59 More Information

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D (2004. ) Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids. Infection and immunity, , 72 (2 ) ,757-65

Linke, Michael J; Rebholz, Sandy; Collins, Margaret; Tanaka, Reiko; Cushion, Melanie T (2003. ) Noninvasive method for monitoring Pneumocystis carinii pneumonia.Emerging infectious diseases, , 9 (12 ) ,1613-6 More Information

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D (2003. ) New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infection and immunity, , 71 (11 ) ,6292-7

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D (2002. ) Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons.The Journal of infectious diseases, , 186 (5 ) ,644-51 More Information

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C (2002. ) Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma.Developmental neuroscience, , 24 (2-3 ) ,154-60 More Information

Contact Information

Academic - Cincinnati Department of Veteran Affairs Medical Center
3200 Vine Street
CincinnatiĀ  Ohio, 45220
Phone: 513-861-3100
Fax: 513-475-6415
Michael.Linke@va.gov