Michael J Linke, PhD

Bachelor's Degree: St. Joseph's College 1981 (Biology)

Master's Degree: St. Thomas Institute 1983 (Biology and Experimental Medicine)

Doctoral Degree: University of Cincinnati 1993 (Pathology and Laboratory medicine)

Fellowship: Children's Hospital Research Foundation 1995 (Pulmonary Biology)

Pneumocystis

Grant: #153185.5121205.0413/Ul1TR002541 Investigators:Linke, Michael 05-15-2021 -04-30-2023 National Center for Advancing Translational Sciences SMART IRB Ambassadors - The Harvard Clinical and Translational Science Center Role:PI 70031.00 Hold Level:Federal

06-16-2023 -06-14-2024 National Institute on Drug Abuse SMART IRB Governance, Administration, and Operations Support Role:PI 281198.61 Hold Level:Federal

06-16-2023 -06-14-2024 National Institute on Drug Abuse SMART IRB Governance, Administration, and Operations Support Role:PI 281198.61 Hold Level:Federal

Grant: #U01NS086872 Investigators:Benken, Laura; Broderick, Joseph; Frasure, Jamey; Khatri, Pooja; Linke, Michael; Mistry, Eva; Vagal, Achala 12-01-2023 -11-30-2028 National Institute of Neurological Disorders and Stroke NIH StrokeNet National Clinical Coordinating Center (NCC) Role:Collaborator 2948572.00 Hold Level:Federal

Peer Reviewed Publications

Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T  (2013). Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infection and immunity, 81 (3) , 984-95More Information

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D  (2010). Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PloS one, 5 (1) , e8524More Information

Linke, Michael J; Ashbaugh, Alan D; Demland, Jeffery A; Walzer, Peter D  (2009). Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure. Respiratory research, 10, 10More Information

Cushion, Melanie T; Collins, Margaret S; Linke, Michael J  (2009). Biofilm formation by Pneumocystis spp. Eukaryotic cell, 8 (2) , 197-206More Information

Linke, Michael J; Ashbaugh, Alan A; Koch, Judith V; Levin, Linda; Tanaka, Reiko; Walzer, Peter DEffects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice. The Journal of eukaryotic microbiology, 56 (1) , 58-65More Information

Motz, Gregory T; Eppert, Bryan L; Sun, Guangyun; Wesselkamper, Scott C; Linke, Michael J; Deka, Ranjan; Borchers, Michael T  (2008). Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. Journal of immunology (Baltimore, Md. : 1950), 181 (11) , 8036-43

Koneti, Adi; Linke, Michael J; Brummer, Elmer; Stevens, David A  (2008). Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis. Infection and immunity, 76 (3) , 994-1002More Information

Keely, Scott P; Linke, Michael J; Cushion, Melanie T; Stringer, James R  (2007). Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription. Fungal genetics and biology : FG & B, 44 (9) , 905-19More Information

Lekkala, Madhavi; LeVine, Ann Marie; Linke, Michael J; Crouch, Erika C; Linders, Bruce; Brummer, Elmer; Stevens, David A  (2006). Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D. Infection and immunity, 74 (8) , 4549-56More Information

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter  (2006). Efficient resolution of Pneumocystis murina infection in surfactant protein A-deficient mice following withdrawal of corticosteroid-induced immunosuppression. Journal of medical microbiology, 55 (Pt 2) , 143-7More Information

Linke, Michael; Ashbaugh, Alan; Demland, Jeffery; Koch, Judith; Tanaka, Reiko; Walzer, Peter  (2006). Resolution of Pneumocystis murina infection following withdrawal of corticosteroid induced immunosuppression. Microbial pathogenesis, 40 (1) , 15-22More Information

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M  (2005). Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, 2 (2) , 149-55

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter  (2005). Surfactant protein A limits Pneumocystis murina infection in immunosuppressed C3H/HeN mice and modulates host response during infection. Microbes and infection / Institut Pasteur, 7 (4) , 748-59More Information

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D  (2004). Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids. Infection and immunity, 72 (2) , 757-65

Linke, Michael J; Rebholz, Sandy; Collins, Margaret; Tanaka, Reiko; Cushion, Melanie T  (2003). Noninvasive method for monitoring Pneumocystis carinii pneumonia. Emerging infectious diseases, 9 (12) , 1613-6More Information

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D  (2003). New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infection and immunity, 71 (11) , 6292-7

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D  (2002). Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons. The Journal of infectious diseases, 186 (5) , 644-51More Information

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C  (2002). Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma. Developmental neuroscience, 24 (2-3) , 154-60More Information

Dickert, Neal W; Metz, Kathleen; Deeds, S Iris; Linke, Michael J; Mitchell, Andrea R; Speight, Candace D; Adeoye, Opeolu M  (2022). Getting the Most out of Consent: Patient-Centered Consent for an Acute Stroke Trial. Ethics & human research, 44 (2) , 33-40More Information

McMullan, Jason; Droege, Christopher; Strilka, Col Richard; Lindsell, Christopher; Linke, Michael J  (2021). Food and Drug Administration and Institutional Review Board Approval of a Novel Prehospital Informed Consent Process for Emergency Research. Prehospital emergency care, 25 (4) , 512-518More Information

Lazzarini, Cristina; Haranahalli, Krupanandan; Rieger, Robert; Ananthula, Hari Krishna; Desai, Pankaj B; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie T; Ruzsicska, Bela; Haley, John; Ojima, Iwao; Del Poeta, Maurizio  (2018). Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids. Antimicrobial agents and chemotherapy, 62 (5) More Information

Cushion, Melanie T; Ashbaugh, Alan; Hendrix, Keeley; Linke, Michael J; Tisdale, Nikeya; Sayson, Steven G; Porollo, Aleksey  (2018). Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation. Antimicrobial agents and chemotherapy, 62 (5) More Information

Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio  (2018). Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids". mBio, 9 (2) More Information

Espay, Alberto J; Dwivedi, Alok; Lang, Anthony E; Linke, Michael J; Szaflarski, Jerzy P  (2015). Author response. Neurology, 85 (8) , 742-3More Information

Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio  (2015). Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids. mBio, 6 (3) , e00647More Information

Espay, Alberto J; Norris, Matthew M; Eliassen, James C; Dwivedi, Alok; Smith, Matthew S; Banks, Christi; Allendorfer, Jane B; Lang, Anthony E; Fleck, David E; Linke, Michael J; Szaflarski, Jerzy P  (2015). Placebo effect of medication cost in Parkinson disease: a randomized double-blind study. Neurology, 84 (8) , 794-802More Information

Academic - Cincinnati Department of Veteran Affairs Medical Center
3200 Vine Street
Cincinnati  Ohio, 45220
Phone: 513-861-3100
Fax: 513-475-6415
Michael.Linke@va.gov