Min Liu

Min Liu

Professor

Education

Doctorate, Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMS) China, 1994 (Molecular Neuron-Pharmacology)

Positions and Work Experience

- Associate Professor, Department of Pathology and Laboratory Medicine, Metabolic Disease Institute Cincinnati - GRIA 261

Research and Practice Interests

Dr. Liu's laboratory is currently studying the role of hypothalamic apolipoprotein AIV (apo AIV) in the development of obesity and how it can be modulated for preventive and therapeutic purposes.

Apo AIV is a circulating signal released from intestinal cells in response to lipid feeding, and it contributes to the anorectic effect of a lipid meal.

We have demonstrated that apo AIV is also synthesized in the hypothalamus, and that hypothalamic apo AIV gene and protein expression is regulated physiologically.

Current work focuses on:

To determine hypothalamic apo AIV gene expression and protein levels and the responsivity of hypothalamic apo AIV to dietary lipids in several strains of obese and lean animals. We will also determine the response to chronic high-fat feeding in apo AIV knockout mice.

To characterize the transport of apo AIV from blood into the central nervous system and to assess the areas in the brain that are activated by apo AIV administered either centrally or intravenously.

To determine the interaction of apo AIV with other regulatory peptides within the hypothalamus. This work is innovative because it addresses important unanswered questions. The new knowledge may lead to novel targets for preventive and therapeutic interventions that will be particularly important to the growing numbers of obese persons in this country

Research Support

Grant: #R01 DK070992 Investigators:Liu, Min 01-01-2007 -11-30-2011 National Institute of Diabetes and Digestive and Kidney Diseases Regulation of Food Intake and Body Weight by Brain Apolipoprotein E Role:PI Active 000593-001 Level:Federal

Grant: #R01-DK-063907 Investigators:Liu, Min 04-01-2003 -01-31-2009 National Institute of Diabetes and Digestive and Kidney Diseases Brain Apolipoprotein AIV, Food Intake and Obesity Role:PI Closed 004131-001 Level:Federal

Grant: #R01 DK092779 Investigators:Liu, Min; Tso, Patrick P.W.; Woods, Stephen 07-22-2011 -05-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Brain ApoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female Rats Role:PI $1,075,839.00 Active Level:Federal

Grant: #R01DK095440 Investigators:Liu, Min; Woods, Stephen 04-01-2012 -01-31-2017 National Inst of Diabetes and Digestive and Kidney Disease Ginsenocide Rb1: A Novel Anti-Obesity and Anti-Hyperglycemic Compound Role:Collaborator $647,861.00 Active Level:Federal

Grant: #U2CDK059630 Investigators:Benoit, Stephen; Davidson, William; Howles, Philip; Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 08-01-2016 -06-30-2021 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator $926,069.68 Active Level:Federal

Grant: #R01 HL140962 Investigators:Hao, Jiukuan; Hui, David; Liu, Min; Millard, Ronald; Wang, Yi-Gang; Xu, Meifeng 03-15-2018 -01-31-2022 National Heart, Lung and Blood Institute Smarter exosomes derived from engineered MSCs promote neo-vascularization Role:Collaborator $502,815.00 Active Level:Federal

Grant: #R01DK119135 Investigators:Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Woods, Stephen 09-20-2018 -05-31-2023 National Inst of Diabetes and Digestive and Kidney Disease Role of the GI lymphatic system in hormonal signaling and nutrient metabolism Role:Collaborator $616,764.00 Active Level:Federal

Publications

Peer Reviewed Publications

Shen L, Tso P, Woods, S.C., Clegg, BJ, Barber KL, Carey K, Liu M. (2008. )Brain Apolipoprotein E: An Important Regulator of Food Intake in Rats. Diabetes. Diabetes, ,57 (8 ),2092-8

Shen L, Pearson KJ, Xiong Y, Lo CM, Tso P, Woods SC, Davidson WS, Liu M (2008. )Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis .Physiol Behav, ,95 (1-2 ),161-7

Jandacek, R., Anderson N., Liu, M., Zheng, S., Yang, Q., Tso, P (2005. )Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene .American Journal of Physiology-Gastrointestinal and Liver physiology, ,288 ,G292-9

Pearson, K., Liu, M., Shen L., Woods, S.C., Tso P., Davidson, W. S (2005. )Bacterial expression and characterization of rat and mouse apolipoprotein .E. Protein Expression and Purification, ,41 ,447-53

Shen, L., Ma, L.Y., Jandacek R. and Sakai, R. Liu, M (2005. )Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. American Journal of Physiology-Gastrointestinal and Liver physiology, ,288 ,G48-53

May, Aaron A; Bedel, Nicholas D; Shen, Ling; Woods, Stephen C; Liu, Min (2016. )Estrogen and insulin transport through the blood-brain barrier.Physiology & behavior, ,163 ,312-321

Wang, H H; Liu, M; Portincasa, P; Tso, P; Wang, D Q-H (2016. )Lack of endogenous cholecystokinin promotes cholelithogenesis in mice.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, ,28 (3 ),364-75

Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. )Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.Physiology & behavior, ,152 (Pt A ),62-7

de Bari, Ornella; Wang, Helen H; Portincasa, Piero; Liu, Min; Wang, David Q-H (2015. )The deletion of the estrogen receptor ? gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice.Biochimica et biophysica acta, ,1852 (10 Pt A ),2161-9

de Bari, Ornella; Wang, Tony Y; Liu, Min; Portincasa, Piero; Wang, David Q-H (2015. )Estrogen induces two distinct cholesterol crystallization pathways by activating ER? and GPR30 in female mice.Journal of lipid research, ,56 (9 ),1691-700

Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. )Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.Physiological reports, ,3 (9 ),

Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick (2015. )Apolipoprotein A-IV: a protein intimately involved in metabolism.Journal of lipid research, ,56 (8 ),1403-18

Begg, Denovan P; May, Aaron A; Mul, Joram D; Liu, Min; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C (2015. )Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.Diabetes, ,64 (7 ),2457-66

Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick (2015. )ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.American journal of physiology. Gastrointestinal and liver physiology, ,308 (6 ),G472-81

Li, Xiaoming; Xu, Min; Liu, Min; Ji, Yong; Li, Zongfang (2015. )TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells.Journal of inflammation (London, England), ,12 ,22

de Bari, Ornella; Wang, Tony Y; Liu, Min; Paik, Chang-Nyol; Portincasa, Piero; Wang, David Q-H Cholesterol cholelithiasis in pregnant women: pathogenesis, prevention and treatment. Annals of hepatology, ,13 (6 ),728-45

Shen, Ling; Liu, Yin; Wang, David Q H; Tso, Patrick; Woods, Stephen C; Liu, Min (2014. )Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-?.Endocrinology, ,155 (10 ),3882-90

Shen, Ling; Xiong, Ye; Wang, David Q-H; Howles, Philip; Basford, Joshua E; Wang, Jiang; Xiong, Yu Qing; Hui, David Y; Woods, Stephen C; Liu, Min (2013. )Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats.Journal of lipid research, ,54 (5 ),1430-8

Begg, Denovan P; Mul, Joram D; Liu, Min; Reedy, Brianne M; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C (2013. )Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.Endocrinology, ,154 (3 ),1047-54

Lo, Chunmin C; Langhans, Wolfgang; Georgievsky, Maria; Arnold, Myrtha; Caldwell, Jody L; Cheng, Stacy; Liu, Min; Woods, Stephen C; Tso, Patrick (2012. )Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake.Endocrinology, ,153 (12 ),5857-65

Liu, Min; Kuhel, David G; Shen, Ling; Hui, David Y; Woods, Stephen C (2012. )Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice.American journal of physiology. Regulatory, integrative and comparative physiology, ,303 (9 ),R903-8

Liu, Min; Shen, Ling; Begg, Denovan P; D'alessio, David A; Woods, Stephen C (2012. )Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats.Journal of neuroscience methods, ,209 (1 ),106-12

Shen, Ling; Hillebrand, Allix; Wang, David Q-H; Liu, Min (2012. )Isolation and primary culture of rat hepatic cells.Journal of visualized experiments : JoVE, ,(64 ),

Yoshimichi, Go; Lo, Chunmin C; Tamashiro, Kellie L K; Ma, Liyun; Lee, Dana M; Begg, Denovan P; Liu, Min; Sakai, Randall R; Woods, Stephen C; Yoshimatsu, Hironobu; Tso, Patrick (2012. )Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.American journal of physiology. Gastrointestinal and liver physiology, ,302 (11 ),G1336-42

Shen, Ling; Wang, David Q-H; Tso, Patrick; Jandacek, Ronald J; Woods, Stephen C; Liu, Min (2011. )Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus.Physiology & behavior, ,105 (1 ),124-8

Lo, Chun-Min; Obici, Silvana; Dong, H Henry; Haas, Michael; Lou, Dawnwen; Kim, Dae Hyun; Liu, Min; D'Alessio, David; Woods, Stephen C; Tso, Patrick (2011. )Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.Diabetes, ,60 (7 ),2000-7

Xiong, Ye; Shen, Ling; Liu, Kristina J; Tso, Patrick; Xiong, Yuqing; Wang, Guangji; Woods, Stephen C; Liu, Min (2010. )Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.Diabetes, ,59 (10 ),2505-12

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. )Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, ,151 (7 ),3163-8

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min (2009. )Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior, ,98 (1-2 ),223-8

Shen, Ling; Carey, Katherine; Wang, David Q-H; Woods, Stephen C; Liu, Min (2009. )Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats.Brain research, ,1273 ,66-71

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick (2009. )Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration.American journal of physiology. Regulatory, integrative and comparative physiology, ,296 (1 ),R43-50

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min (2008. )Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis.Physiology & behavior, ,95 (1-2 ),161-7

Shen, Ling; Tso, Patrick; Woods, Stephen C; Clegg, Deborah J; Barber, Kyna L; Carey, Katherine; Liu, Min (2008. )Brain apolipoprotein E: an important regulator of food intake in rats.Diabetes, ,57 (8 ),2092-8

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. )Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, ,293 (4 ),R1490-4

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. )Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, ,282 (39 ),28385-94

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. )Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, ,148 (6 ),2681-9

Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick (2007. )Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.American journal of physiology. Regulatory, integrative and comparative physiology, ,292 (1 ),R268-73

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C (2006. )Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.American journal of physiology. Regulatory, integrative and comparative physiology, ,290 (1 ),R202-7

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. )Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, ,41 (2 ),447-53

Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick (2005. )GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.American journal of physiology. Gastrointestinal and liver physiology, ,288 (5 ),G943-9

Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick (2005. )Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.American journal of physiology. Gastrointestinal and liver physiology, ,288 (2 ),G292-9

Shen, Ling; Ma, Li-yun; Qin, Xiao-fa; Jandacek, Ronald; Sakai, Randall; Liu, Min (2005. )Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats.American journal of physiology. Gastrointestinal and liver physiology, ,288 (1 ),G48-53

Tso, Patrick; Liu, Min (2004. )Apolipoprotein A-IV, food intake, and obesity.Physiology & behavior, ,83 (4 ),631-43

Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J (2004. )Consumption of a high-fat diet alters the homeostatic regulation of energy balance.Physiology & behavior, ,83 (4 ),573-8

Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick (2004. )Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus.American journal of physiology. Endocrinology and metabolism, ,287 (2 ),E366-70

Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick (2004. )Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone.Endocrinology, ,145 (7 ),3232-8

Tso, Patrick; Sun, William; Liu, Min (2004. )Gastrointestinal satiety signals IV. Apolipoprotein A-IV.American journal of physiology. Gastrointestinal and liver physiology, ,286 (6 ),G885-90

Tso, Patrick; Liu, Min (2004. )Ingested fat and satiety.Physiology & behavior, ,81 (2 ),275-87

Liu, Min; Doi, Takashi; Tso, Patrick (2003. )Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), ,228 (10 ),1181-9

Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick (2003. )Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, ,971 (2 ),232-8

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. )Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, ,78 (1 ),149-55

Doi, T; Liu, M; Seeley, R J; Woods, S C; Tso, P (2001. )Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. American journal of physiology. Regulatory, integrative and comparative physiology, ,281 (3 ),R753-9

Liu, M; Doi, T; Shen, L; Woods, S C; Seeley, R J; Zheng, S; Jackman, A; Tso, P (2001. )Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology, ,280 (5 ),R1382-7

Tso, P; Liu, M; Kalogeris, T J; Thomson, A B (2001. )The role of apolipoprotein A-IV in the regulation of food intake.Annual review of nutrition, ,21 ,231-54

Liu, M; Shen, L; Tso, P (1999. )The role of enterostatin and apolipoprotein AIV on the control of food intake.Neuropeptides, ,33 (5 ),425-33

Tso, P; Liu, M; Kalogeris, T J (1999. )The role of apolipoprotein A-IV in food intake regulation. The Journal of nutrition, ,129 (8 ),1503-6

Duan, Yuping; Zhu, Wei; Liu, Min; Ashraf, Muhammad; Xu, Meifeng (2017. )The expression of Smad signaling pathway in myocardium and potential therapeutic effects.Histology and histopathology, ,32 (7 ),651-659

Gong, Min; Yu, Bin; Wang, Jingcai; Wang, Yigang; Liu, Min; Paul, Christian; Millard, Ronald W; Xiao, De-Sheng; Ashraf, Muhammad; Xu, Meifeng (2017. )Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis.Oncotarget, ,

Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P (2016. )Using the cerebrospinal fluid to understand ingestive behavior.Physiology & behavior, ,

May, Aaron A; Liu, Min; Woods, Stephen C; Begg, Denovan P (2016. )CCK increases the transport of insulin into the brain.Physiology & behavior, ,165 ,392-7

Contact Information

Research - Metabolic Diseases Institute
2120 Galbraith Road
ReadingĀ  Ohio, 45215
Phone: (513) 558-4957
min.liu@uc.edu