Min Liu

Min Liu , PhD

Professor

Education

Doctorate: Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMS) China, 1994 (Molecular Neuron-Pharmacology)

Research and Practice Interests

Dr. Liu's laboratory is currently studying the role of hypothalamic apolipoprotein AIV (apo AIV) in the development of obesity and how it can be modulated for preventive and therapeutic purposes.

Apo AIV is a circulating signal released from intestinal cells in response to lipid feeding, and it contributes to the anorectic effect of a lipid meal.

We have demonstrated that apo AIV is also synthesized in the hypothalamus, and that hypothalamic apo AIV gene and protein expression is regulated physiologically.

Current work focuses on:

To determine hypothalamic apo AIV gene expression and protein levels and the responsivity of hypothalamic apo AIV to dietary lipids in several strains of obese and lean animals. We will also determine the response to chronic high-fat feeding in apo AIV knockout mice.

To characterize the transport of apo AIV from blood into the central nervous system and to assess the areas in the brain that are activated by apo AIV administered either centrally or intravenously.

To determine the interaction of apo AIV with other regulatory peptides within the hypothalamus. This work is innovative because it addresses important unanswered questions. The new knowledge may lead to novel targets for preventive and therapeutic interventions that will be particularly important to the growing numbers of obese persons in this country

Positions and Work Experience

- Associate Professor, Department of Pathology and Laboratory Medicine, Metabolic Disease Institute Cincinnati - GRIA 261

Research Support

Grant: #R01 DK070992 Investigators:Liu, Min 01-01-2007 -11-30-2011 National Institute of Diabetes and Digestive and Kidney Diseases Regulation of Food Intake and Body Weight by Brain Apolipoprotein E Role:PI Active 000593-001 Level:Federal

Grant: #R01-DK-063907 Investigators:Liu, Min 04-01-2003 -01-31-2009 National Institute of Diabetes and Digestive and Kidney Diseases Brain Apolipoprotein AIV, Food Intake and Obesity Role:PI Closed 004131-001 Level:Federal

Grant: #R01 DK092779 Investigators:Liu, Min; Tso, Patrick P.W.; Woods, Stephen 07-22-2011 -05-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Brain ApoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female Rats Role:PI $1,075,839.00 Active Level:Federal

Grant: #R01DK095440 Investigators:Liu, Min; Woods, Stephen 04-01-2012 -01-31-2017 National Inst of Diabetes and Digestive and Kidney Disease Ginsenocide Rb1: A Novel Anti-Obesity and Anti-Hyperglycemic Compound Role:Collaborator $647,861.00 Active Level:Federal

Grant: #U2CDK059630 Investigators:Benoit, Stephen; Davidson, William; Howles, Philip; Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 08-01-2016 -06-30-2021 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator $926,069.68 Active Level:Federal

Grant: #R01 HL140962 Investigators:Hao, Jiukuan; Hui, David; Liu, Min; Millard, Ronald; Wang, Yi-Gang; Xu, Meifeng 03-15-2018 -01-31-2022 National Heart, Lung and Blood Institute Smarter exosomes derived from engineered MSCs promote neo-vascularization Role:Collaborator $502,815.00 Active Level:Federal

Grant: #R01DK119135 Investigators:Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Woods, Stephen 09-20-2018 -05-31-2023 National Inst of Diabetes and Digestive and Kidney Disease Role of the GI lymphatic system in hormonal signaling and nutrient metabolism Role:Collaborator $616,764.00 Active Level:Federal

Grant: #U2CDK059630 Investigators:Davidson, William; Liu, Min; Reyes, Teresa; Tso, Patrick; Ulrich-Lai, Yvonne 07-01-2021 -06-30-2026 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator 0.00 Hold Level:Federal

Investigators:Liu, Min 11-01-2021 -04-30-2022 Chromadex Rat Portal Vein Cannulation Study Role:PI 65790.00 Hold Level:Industry

Publications

Peer Reviewed Publications

Shen L, Tso P, Woods, S.C., Clegg, BJ, Barber KL, Carey K, Liu M. (2008. ) Brain Apolipoprotein E: An Important Regulator of Food Intake in Rats. Diabetes. Diabetes, , 57 (8 ) ,2092-8

Shen L, Pearson KJ, Xiong Y, Lo CM, Tso P, Woods SC, Davidson WS, Liu M (2008. ) Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis .Physiol Behav, , 95 (1-2 ) ,161-7

Jandacek, R., Anderson N., Liu, M., Zheng, S., Yang, Q., Tso, P (2005. ) Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene .American Journal of Physiology-Gastrointestinal and Liver physiology, , 288 ,G292-9

Pearson, K., Liu, M., Shen L., Woods, S.C., Tso P., Davidson, W. S (2005. ) Bacterial expression and characterization of rat and mouse apolipoprotein .E. Protein Expression and Purification, , 41 ,447-53

Shen, L., Ma, L.Y., Jandacek R. and Sakai, R. Liu, M (2005. ) Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. American Journal of Physiology-Gastrointestinal and Liver physiology, , 288 ,G48-53

May, Aaron A; Bedel, Nicholas D; Shen, Ling; Woods, Stephen C; Liu, Min (2016. ) Estrogen and insulin transport through the blood-brain barrier.Physiology & behavior, , 163 ,312-321 More Information

Wang, H H; Liu, M; Portincasa, P; Tso, P; Wang, D Q-H (2016. ) Lack of endogenous cholecystokinin promotes cholelithogenesis in mice.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, , 28 (3 ) ,364-75 More Information

Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. ) Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.Physiology & behavior, , 152 (Pt A ) ,62-7 More Information

de Bari, Ornella; Wang, Helen H; Portincasa, Piero; Liu, Min; Wang, David Q-H (2015. ) The deletion of the estrogen receptor ? gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice.Biochimica et biophysica acta, , 1852 (10 Pt A ) ,2161-9 More Information

de Bari, Ornella; Wang, Tony Y; Liu, Min; Portincasa, Piero; Wang, David Q-H (2015. ) Estrogen induces two distinct cholesterol crystallization pathways by activating ER? and GPR30 in female mice.Journal of lipid research, , 56 (9 ) ,1691-700 More Information

Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. ) Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.Physiological reports, , 3 (9 ) , More Information

Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick (2015. ) Apolipoprotein A-IV: a protein intimately involved in metabolism.Journal of lipid research, , 56 (8 ) ,1403-18 More Information

Begg, Denovan P; May, Aaron A; Mul, Joram D; Liu, Min; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C (2015. ) Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.Diabetes, , 64 (7 ) ,2457-66 More Information

Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick (2015. ) ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G472-81 More Information

Li, Xiaoming; Xu, Min; Liu, Min; Ji, Yong; Li, Zongfang (2015. ) TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells.Journal of inflammation (London, England), , 12 ,22 More Information

de Bari, Ornella; Wang, Tony Y; Liu, Min; Paik, Chang-Nyol; Portincasa, Piero; Wang, David Q-H Cholesterol cholelithiasis in pregnant women: pathogenesis, prevention and treatment. Annals of hepatology, , 13 (6 ) ,728-45

Shen, Ling; Liu, Yin; Wang, David Q H; Tso, Patrick; Woods, Stephen C; Liu, Min (2014. ) Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-?.Endocrinology, , 155 (10 ) ,3882-90 More Information

Shen, Ling; Xiong, Ye; Wang, David Q-H; Howles, Philip; Basford, Joshua E; Wang, Jiang; Xiong, Yu Qing; Hui, David Y; Woods, Stephen C; Liu, Min (2013. ) Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats.Journal of lipid research, , 54 (5 ) ,1430-8 More Information

Begg, Denovan P; Mul, Joram D; Liu, Min; Reedy, Brianne M; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C (2013. ) Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.Endocrinology, , 154 (3 ) ,1047-54 More Information

Lo, Chunmin C; Langhans, Wolfgang; Georgievsky, Maria; Arnold, Myrtha; Caldwell, Jody L; Cheng, Stacy; Liu, Min; Woods, Stephen C; Tso, Patrick (2012. ) Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake.Endocrinology, , 153 (12 ) ,5857-65 More Information

Liu, Min; Kuhel, David G; Shen, Ling; Hui, David Y; Woods, Stephen C (2012. ) Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice.American journal of physiology. Regulatory, integrative and comparative physiology, , 303 (9 ) ,R903-8 More Information

Liu, Min; Shen, Ling; Begg, Denovan P; D'alessio, David A; Woods, Stephen C (2012. ) Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats.Journal of neuroscience methods, , 209 (1 ) ,106-12 More Information

Shen, Ling; Hillebrand, Allix; Wang, David Q-H; Liu, Min (2012. ) Isolation and primary culture of rat hepatic cells.Journal of visualized experiments : JoVE, , (64 ) , More Information

Yoshimichi, Go; Lo, Chunmin C; Tamashiro, Kellie L K; Ma, Liyun; Lee, Dana M; Begg, Denovan P; Liu, Min; Sakai, Randall R; Woods, Stephen C; Yoshimatsu, Hironobu; Tso, Patrick (2012. ) Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.American journal of physiology. Gastrointestinal and liver physiology, , 302 (11 ) ,G1336-42 More Information

Shen, Ling; Wang, David Q-H; Tso, Patrick; Jandacek, Ronald J; Woods, Stephen C; Liu, Min (2011. ) Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus.Physiology & behavior, , 105 (1 ) ,124-8 More Information

Lo, Chun-Min; Obici, Silvana; Dong, H Henry; Haas, Michael; Lou, Dawnwen; Kim, Dae Hyun; Liu, Min; D'Alessio, David; Woods, Stephen C; Tso, Patrick (2011. ) Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.Diabetes, , 60 (7 ) ,2000-7 More Information

Xiong, Ye; Shen, Ling; Liu, Kristina J; Tso, Patrick; Xiong, Yuqing; Wang, Guangji; Woods, Stephen C; Liu, Min (2010. ) Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.Diabetes, , 59 (10 ) ,2505-12 More Information

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. ) Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, , 151 (7 ) ,3163-8 More Information

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min (2009. ) Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior, , 98 (1-2 ) ,223-8 More Information

Shen, Ling; Carey, Katherine; Wang, David Q-H; Woods, Stephen C; Liu, Min (2009. ) Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats.Brain research, , 1273 ,66-71 More Information

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick (2009. ) Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration.American journal of physiology. Regulatory, integrative and comparative physiology, , 296 (1 ) ,R43-50 More Information

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min (2008. ) Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis.Physiology & behavior, , 95 (1-2 ) ,161-7 More Information

Shen, Ling; Tso, Patrick; Woods, Stephen C; Clegg, Deborah J; Barber, Kyna L; Carey, Katherine; Liu, Min (2008. ) Brain apolipoprotein E: an important regulator of food intake in rats.Diabetes, , 57 (8 ) ,2092-8 More Information

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. ) Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1490-4 More Information

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. ) Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, , 282 (39 ) ,28385-94 More Information

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. ) Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, , 148 (6 ) ,2681-9 More Information

Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick (2007. ) Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.American journal of physiology. Regulatory, integrative and comparative physiology, , 292 (1 ) ,R268-73 More Information

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C (2006. ) Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 290 (1 ) ,R202-7 More Information

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. ) Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, , 41 (2 ) ,447-53 More Information

Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick (2005. ) GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.American journal of physiology. Gastrointestinal and liver physiology, , 288 (5 ) ,G943-9 More Information

Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick (2005. ) Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.American journal of physiology. Gastrointestinal and liver physiology, , 288 (2 ) ,G292-9 More Information

Shen, Ling; Ma, Li-yun; Qin, Xiao-fa; Jandacek, Ronald; Sakai, Randall; Liu, Min (2005. ) Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats.American journal of physiology. Gastrointestinal and liver physiology, , 288 (1 ) ,G48-53 More Information

Tso, Patrick; Liu, Min (2004. ) Apolipoprotein A-IV, food intake, and obesity.Physiology & behavior, , 83 (4 ) ,631-43 More Information

Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J (2004. ) Consumption of a high-fat diet alters the homeostatic regulation of energy balance.Physiology & behavior, , 83 (4 ) ,573-8 More Information

Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick (2004. ) Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus.American journal of physiology. Endocrinology and metabolism, , 287 (2 ) ,E366-70 More Information

Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick (2004. ) Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone.Endocrinology, , 145 (7 ) ,3232-8 More Information

Tso, Patrick; Sun, William; Liu, Min (2004. ) Gastrointestinal satiety signals IV. Apolipoprotein A-IV.American journal of physiology. Gastrointestinal and liver physiology, , 286 (6 ) ,G885-90 More Information

Tso, Patrick; Liu, Min (2004. ) Ingested fat and satiety.Physiology & behavior, , 81 (2 ) ,275-87 More Information

Liu, Min; Doi, Takashi; Tso, Patrick (2003. ) Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), , 228 (10 ) ,1181-9

Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick (2003. ) Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, , 971 (2 ) ,232-8

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. ) Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, , 78 (1 ) ,149-55

Doi, T; Liu, M; Seeley, R J; Woods, S C; Tso, P (2001. ) Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. American journal of physiology. Regulatory, integrative and comparative physiology, , 281 (3 ) ,R753-9

Liu, M; Doi, T; Shen, L; Woods, S C; Seeley, R J; Zheng, S; Jackman, A; Tso, P (2001. ) Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology, , 280 (5 ) ,R1382-7

Tso, P; Liu, M; Kalogeris, T J; Thomson, A B (2001. ) The role of apolipoprotein A-IV in the regulation of food intake.Annual review of nutrition, , 21 ,231-54 More Information

Liu, M; Shen, L; Tso, P (1999. ) The role of enterostatin and apolipoprotein AIV on the control of food intake.Neuropeptides, , 33 (5 ) ,425-33 More Information

Tso, P; Liu, M; Kalogeris, T J (1999. ) The role of apolipoprotein A-IV in food intake regulation. The Journal of nutrition, , 129 (8 ) ,1503-6

Duan, Yuping; Zhu, Wei; Liu, Min; Ashraf, Muhammad; Xu, Meifeng (2017. ) The expression of Smad signaling pathway in myocardium and potential therapeutic effects.Histology and histopathology, , 32 (7 ) ,651-659 More Information

Gong, Min; Yu, Bin; Wang, Jingcai; Wang, Yigang; Liu, Min; Paul, Christian; Millard, Ronald W; Xiao, De-Sheng; Ashraf, Muhammad; Xu, Meifeng (2017. ) Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis.Oncotarget, , More Information

Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P (2016. ) Using the cerebrospinal fluid to understand ingestive behavior.Physiology & behavior, , More Information

May, Aaron A; Liu, Min; Woods, Stephen C; Begg, Denovan P (2016. ) CCK increases the transport of insulin into the brain.Physiology & behavior, , 165 ,392-7 More Information

Contact Information

Research - Metabolic Diseases Institute
2120 Galbraith Road
ReadingĀ  Ohio, 45215
Phone: (513) 558-4957
min.liu@uc.edu