Paul Luethy

I am a board-certified clinical microbiologist specializing in the laboratory diagnosis of infectious diseases. At Cincinnati Children’s, I direct the microbiology laboratory to ensure we deliver high-quality, impactful results for every patient. I also provide clinical microbiology consultative services to our clinical teams, working closely with physicians and staff to help guide care decisions based on the most accurate and timely laboratory findings. 
My journey into clinical microbiology began during my graduate training, when I realized the everyday impact I could have on patients’ lives through this role. It’s incredibly rewarding to know that the work we do in the lab directly supports the care and recovery of children and their families.

B.S.: Michigan State University East Lansing, MI, 2010 (Biochemistry and Molecular Biology)

Ph.D.: University of Texas Southwestern Medical Center Dallas, TX, 2015 (Molecular Microbiology)

Fellowship: National Institutes of Health Bethesda, MD, 2017 (Clinical and Public Health Microbiology)

My research focuses on evaluating novel microbiology and molecular technologies for diagnosing infectious diseases. These exciting advancements often allow us to provide results faster and more accurately than ever before, which can make a real difference in treatment. I’m passionate about understanding how these technologies affect disease management and enjoy collaborating with multidisciplinary teams to study their impact.

Peer Reviewed Publications

Mendoza, Lydia M; Mathison, Blaine; Rehman, Aliya; Luethy, Paul M  (2026). The Brief Case: Tastes of travel-intestinal importation. Journal of clinical microbiology, 64 (5) , e0165525More Information

Smith, Richard D; Luethy, Paul M; Riedel, David J  (2025). The Pink Road Less Traveled. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 81 (4) , 815-817More Information

Smith, Richard D; Luethy, Paul M; Kristie Johnson, J  (2025). Evaluation of Group B Streptococcus culture processing using a commercial flocked swab with and without automated sample processing instrument. Microbiology spectrum, 13 (8) , e0124925More Information

Flores, Hannah; Luethy, Paul; Doub, James B  (2024). Discordant Susceptibilities of Enterobacterales to Different Tetracycline Classes. Cureus, 16 (12) , e74917More Information

Rodino, Kyle G; Luethy, Paul M; Abbott, April N; Bender, Jeffrey M; Eberly, Allison R; Gitman, Melissa; Leber, Amy; Dien Bard, Jennifer  (2024). Defining the value of medical microbiology consultation. Journal of clinical microbiology, 62 (10) , e0035924More Information

de Hoog, Sybren; Walsh, Thomas J; Ahmed, Sarah A; Alastruey-Izquierdo, Ana; Alexander, Barbara D; Arendrup, Maiken Cavling; Babady, Esther; Bai, Feng-Yan; Balada-Llasat, Joan-Miquel; Borman, Andrew; Chowdhary, Anuradha; Clark, Andrew; Colgrove, Robert C; Cornely, Oliver A; Dingle, Tanis C; Dufresne, Philippe J; Fuller, Jeff; Gangneux, Jean-Pierre; Gibas, Connie; Glasgow, Heather; Graser, Yvonne; Guillot, Jacques; Groll, Andreas H; Haase, Gerhard; Hanson, Kimberly; Harrington, Amanda; Hawksworth, David L; Hayden, Randall T; Hoenigl, Martin; Hubka, Vit; Johnson, Kristie; Kus, Julianne V; Li, Ruoyu; Meis, Jacques F; Lackner, Michaela; Lanternier, Fanny; Leal, Sixto M; Lee, Francesca; Lockhart, Shawn R; Luethy, Paul; Martin, Isabella; Kwon-Chung, Kyung J; Meyer, Wieland; Nguyen, M Hong; Ostrosky-Zeichner, Luis; Palavecino, Elizabeth; Pancholi, Preeti; Pappas, Peter G; Procop, Gary W; Redhead, Scott A; Rhoads, Daniel D; Riedel, Stefan; Stevens, Bryan; Sullivan, Kaede Ota; Vergidis, Paschalis; Roilides, Emmanuel; Seyedmousavi, Amir; Tao, Lili; Vicente, Vania A; Vitale, Roxana G; Wang, Qi-Ming; Wengenack, Nancy L; Westblade, Lars; Wiederhold, Nathan; White, Lewis; Wojewoda, Christina M; Zhang, Sean X  (2024). Reply to Kidd et al., "Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion". Journal of clinical microbiology, 62 (4) , e0162523More Information

de Hoog, Sybren; Walsh, Thomas J; Ahmed, Sarah A; Alastruey-Izquierdo, Ana; Alexander, Barbara D; Arendrup, Maiken Cavling; Babady, Esther; Bai, Feng-Yan; Balada-Llasat, Joan-Miquel; Borman, Andrew; Chowdhary, Anuradha; Clark, Andrew; Colgrove, Robert C; Cornely, Oliver A; Dingle, Tanis C; Dufresne, Philippe J; Fuller, Jeff; Gangneux, Jean-Pierre; Gibas, Connie; Glasgow, Heather; Gräser, Yvonne; Guillot, Jacques; Groll, Andreas H; Haase, Gerhard; Hanson, Kimberly; Harrington, Amanda; Hawksworth, David L; Hayden, Randall T; Hoenigl, Martin; Hubka, Vit; Johnson, Kristie; Kus, Julianne V; Li, Ruoyu; Meis, Jacques F; Lackner, Michaela; Lanternier, Fanny; Leal, Sixto M; Lee, Francesca; Lockhart, Shawn R; Luethy, Paul; Martin, Isabella; Kwon-Chung, Kyung J; Meyer, Wieland; Nguyen, M Hong; Ostrosky-Zeichner, Luis; Palavecino, Elizabeth; Pancholi, Preeti; Pappas, Peter G; Procop, Gary W; Redhead, Scott A; Rhoads, Daniel D; Riedel, Stefan; Stevens, Bryan; Sullivan, Kaede Ota; Vergidis, Paschalis; Roilides, Emmanuel; Seyedmousavi, Amir; Tao, Lili; Vicente, Vania A; Vitale, Roxana G; Wang, Qi-Ming; Wengenack, Nancy L; Westblade, Lars; Wiederhold, Nathan; White, Lewis; Wojewoda, Christina M; Zhang, Sean X  (2023). A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC. Journal of clinical microbiology, 61 (11) , e0087323More Information

Luethy, Paul M  (2023). Point-of-Care Testing for the Diagnosis of Fungal Infections: Current Testing Applications and Potential for the Future. Clinics in laboratory medicine, 43 (2) , 209-220More Information

Putnam, Nicole E; Youn, Jung-Ho; Wallace, Meghan A; Luethy, Paul M; Burnham, Carey-Ann D; Butler-Wu, Susan; Dekker, John P; Lau, Anna F  (2023). Comparative Evaluation of Current Biochemical-, Sequencing-, and Proteomic-Based Identification Methods for the Streptococcus bovis Group. Journal of clinical microbiology, 61 (4) , e0171222More Information

Heil, Emily L; Claeys, Kimberly C; Kline, Ellen G; Rogers, Tara M; Squires, Kevin M; Iovleva, Alina; Doi, Yohei; Banoub, Mary; Noval, Mandee M; Luethy, Paul M; Shields, Ryan K  (2023). Early initiation of three-drug combinations for the treatment of carbapenem-resistant A. baumannii among COVID-19 patients. The Journal of antimicrobial chemotherapy, 78 (4) , 1034-1040More Information

Traver, Edward C; Saharia, Kapil; Luethy, Paul; Amoroso, Anthony  (2023). Severe Infective Endocarditis Caused by Bartonella rochalimae. Emerging infectious diseases, 30 (2) , 394-396More Information

Rice, Kathryn S; Luethy, Paul M  (2022). Overprediction of Carbapenemase-Containing Isolates by an Automated AST Instrument's Computer Algorithm. The journal of applied laboratory medicine, 7 (6) , 1283-1289More Information

McCarty, Todd P; Luethy, Paul M; Baddley, John W; Pappas, Peter G  (2022). Clinical utility of antifungal susceptibility testing. JAC-antimicrobial resistance, 4 (3) , dlac067More Information

Shishido, Akira A; Noe, Myint; Saharia, Kapil; Luethy, Paul  (2022). Clinical impact of a metagenomic microbial plasma cell-free DNA next-generation sequencing assay on treatment decisions: a single-center retrospective study. BMC infectious diseases, 22 (1) , 372More Information

Harfouch, Omar; Luethy, Paul M; Noval, Mandee; Baghdadi, Jonathan D  (2021). Wohlfahrtiimonas chitiniclastica Monomicrobial Bacteremia in a Homeless Man. Emerging infectious diseases, 27 (12) , 3195-3197More Information

Hardy, Naomi L; Luethy, Paul M  (2021). Evaluation of Inappropriate COVID-19 RT-PCR Test Utilization at an Academic Medical Center. The journal of applied laboratory medicine, 6 (6) , 1484-1491More Information

Luethy, Paul M; Johnson, J Kristie  (2021). Comparison of Three Sample-to-Answer RT-PCR Testing Platforms for the Detection of SARS-CoV-2 RNA in Positive Nasopharyngeal and Nasal Swabs. The journal of applied laboratory medicine, 6 (6) , 1635-1639More Information

Murphy, Colin; Fontaine, Magali; Luethy, Paul; McGann, Heather; Jackson, Bryon  (2021). Blood usage at a large academic center in Maryland in relation to the COVID-19 pandemic in 2020. Transfusion, 61 (7) , 2075-2081More Information

Zhang, Sean X; Babady, N Esther; Hanson, Kimberly E; Harrington, Amanda T; Larkin, Paige M K; Leal, Sixto M; Luethy, Paul M; Martin, Isabella W; Pancholi, Preeti; Procop, Gary W; Riedel, Stefan; Seyedmousavi, Seyedmojtaba; Sullivan, Kaede V; Walsh, Thomas J; Lockhart, Shawn R  (2021). Recognition of Diagnostic Gaps for Laboratory Diagnosis of Fungal Diseases: Expert Opinion from the Fungal Diagnostics Laboratories Consortium (FDLC). Journal of clinical microbiology, 59 (7) , e0178420More Information

Rebechi, Melanie T; Heil, Emily L; Luethy, Paul M; Schmalzle, Sarah A  (2021). Streptococcus pyogenes Infective Endocarditis-Association With Injection Drug Use: Case Series and Review of the Literature. Open forum infectious diseases, 8 (6) , ofab240More Information

Patel, Ashka; Emerick, Michele; Cabunoc, Marie K; Williams, Michelle H; Preas, Michael Anne; Schrank, Gregory; Rabinowitz, Ronald; Luethy, Paul; Johnson, J Kristie; Leekha, Surbhi  (2021). Rapid Spread and Control of Multidrug-Resistant Gram-Negative Bacteria in COVID-19 Patient Care Units. Emerging infectious diseases, 27 (4) , 1234-1237More Information

Hauser, Naomi; Kim, Justin J; Luethy, Paul M; Schmalzle, Sarah A; Bork, Jacqueline T  (2021). Multicenter retrospective cohort study of the clinical significance of Staphylococcus lugdunensis isolated from a single blood culture set. Diagnostic microbiology and infectious disease, 99 (3) , 115261More Information

Hauser, Naomi; Luethy, Paul M; Stamatos, Nicholas  (2021). Listeria Meningitis: An Inconsistent Organism Causing an Inconsistent Disease. The American journal of medicine, 134 (1) , e64-e65More Information

Hauser, Naomi; Luethy, Paul M; Rapaka, Rekha R  (2020). An Immunocompromised Woman with a Brain Lesion. The American journal of medicine, 133 (9) , e516-e517More Information

Kim, Justin J; Luethy, Paul M; Stashek, Kristen M; Koka, Rima; Mathur, Poonam  (2020). Answer to June 2020 Photo Quiz. Journal of clinical microbiology, 58 (6) More Information

Kim, Justin J; Luethy, Paul M; Stashek, Kristen M; Koka, Rima; Mathur, Poonam  (2020). Photo Quiz: An Elderly Leukemia Patient with Jaw Pain and Swelling and Subjective Fevers. Journal of clinical microbiology, 58 (6) More Information

Jakharia, Niyati; Hossain, Aneesha; Luethy, Paul; Riedel, David J  (2019). 48-Year-Old Male With Febrile Neutropenia and Massive Hemolysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69 (12) , 2193-2194More Information

Luethy, Paul M; Johnson, J Kristie  (2019). The Use of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) for the Identification of Pathogens Causing Sepsis. The journal of applied laboratory medicine, 3 (4) , 675-685More Information

Meisel, Jacquelyn S; Nasko, Daniel J; Brubach, Brian; Cepeda-Espinoza, Victoria; Chopyk, Jessica; Corrada-Bravo, Héctor; Fedarko, Marcus; Ghurye, Jay; Javkar, Kiran; Olson, Nathan D; Shah, Nidhi; Allard, Sarah M; Bazinet, Adam L; Bergman, Nicholas H; Brown, Alexis; Caporaso, J Gregory; Conlan, Sean; DiRuggiero, Jocelyne; Forry, Samuel P; Hasan, Nur A; Kralj, Jason; Luethy, Paul M; Milton, Donald K; Ondov, Brian D; Preheim, Sarah; Ratnayake, Shashikala; Rogers, Stephanie M; Rosovitz, M J; Sakowski, Eric G; Schliebs, Nils Oliver; Sommer, Daniel D; Ternus, Krista L; Uritskiy, Gherman; Zhang, Sean X; Pop, Mihai; Treangen, Todd J  (2018). Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018. Microbiome, 6 (1) , 197More Information

Luethy, Paul M; Zelazny, Adrian M  (2018). Rapid one-step extraction method for the identification of molds using MALDI-TOF MS. Diagnostic microbiology and infectious disease, 91 (2) , 130-135More Information

Luethy, Paul M; Murphy, Sean C; Seilie, Annette M; Xie, Yingda L; Lau, Chuen-Yen; Tisdale, John F; Hsieh, Matthew M; Reinhardt, Jessica L; Lau, Anna F; Fahle, Gary A  (2018). Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease. Malaria journal, 17 (1) , 23More Information

Hesse, Shayla E; Luethy, Paul M; Beigel, John H; Zelazny, Adrian M  (2017). Penicillium citrinum: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity. Medical mycology case reports, 17, 8-10More Information

Luethy, Paul M; Huynh, Steven; Ribardo, Deborah A; Winter, Sebastian E; Parker, Craig T; Hendrixson, David R  (2017). Microbiota-Derived Short-Chain Fatty Acids Modulate Expression of Campylobacter jejuni Determinants Required for Commensalism and Virulence. mBio, 8 (3) More Information

Luethy, Paul M; Huynh, Steven; Parker, Craig T; Hendrixson, David R  (2015). Analysis of the activity and regulon of the two-component regulatory system composed by Cjj81176_1484 and Cjj81176_1483 of Campylobacter jejuni. Journal of bacteriology, 197 (9) , 1592-605More Information

Zhang, Yang; Luethy, Paul M; Zhou, Ruanbao; Kroos, Lee  (2013). Residues in conserved loops of intramembrane metalloprotease SpoIVFB interact with residues near the cleavage site in pro-σK. Journal of bacteriology, 195 (21) , 4936-46More Information

Lee, Jun-Seok; Son, Bongjun; Viswanathan, Poorna; Luethy, Paul M; Kroos, Lee  (2011). Combinatorial regulation of fmgD by MrpC2 and FruA during Myxococcus xanthus development. Journal of bacteriology, 193 (7) , 1681-9More Information

Cincinnati Children's Hospital
3333 Burnet Ave, MLC1010
Cincinnati  Ohio, 45229-3026
paul.luethy@cchmc.org