Agnes Luo

Agnes Luo , PhD

Associate Professor

2256 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267
Phone 513-558-1188
Fax 513-558-5604
Email luoy2@ucmail.uc.edu

Professional Summary

Associate Professor of Molecular Genetics at the University of Cincinnati.  Along with Molecular Genetics, Dr. Luo's research interests include Neuroscience, Stroke, Regenerative Medicine, Animal Models of Neurological diseases. Neuroprotection and regeneration. For additional information, please visit: theluolab.com

Education

Bachelor of Science: Nanjing University Nanjiing, China, 1997 (Environmental Biology)

Ph D: University of Rochester Rochester, NY, 2005 (Molecular Toxicology)

Post Doctoral Fellow: National Institute of Drug Abuse, NIH Baltimore, MD, 2008

Research Fellow: National Institute of Drug Abuse, NIH Baltimore, MD, 2009

Research and Practice Interests

Molecular Genetics, Neuroscience, Stroke, Regenerative Medicine, Animal Models of Neurological diseases. Neuroprotection and regeneration.

Positions and Work Experience

- Associate Professor of Molecular Genetics,

Research Support

Grant: #R01NS091213 Investigators:Luo, Yu 08-01-2018 -07-31-2020 National Institute of Neurological Disorders and Stroke Genetic and drug modulation of sonic hedgehog pathway in brain ischemia Role:PI $466,319.25 Active Level:Federal

Grant: #2018 Award Investigators:Luo, Yu 11-01-2018 -10-31-2020 Local Initiative for Excellence (L.I.F.E.) Inhibition of Drpl using a selective Drp1 peptide inhibitor for treatment of alpha-synuclein-associated Parkinson's Disease Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #RES513817 / R01NS094152 Investigators:Luo, Yu 07-01-2018 -06-30-2019 National Institute of Neurological Disorders and Stroke Repositioning Gliptins for Parkinson's Disease Treatment Role:PI $48,000.00 Active Level:Federal

Grant: #R01NS107365 Investigators:Luo, Yu 04-15-2019 -02-28-2023 National Institute of Neurological Disorders and Stroke Modulating a critical inhibitory proteoglycan receptor to promote functional recovery after stroke Role:PI $363,756.00 Awarded Level:Federal

Grant: #S10OD030402 Investigators:Closson, Chet; Fan, Guochang; Hong, Christian; Luo, Yu; Sadayappan, Sakthivel; Wang, Hongsheng; Weiss, Alison; Zhang, Yuhang 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Leica Stellaris 8 Confocal Microscope Role:Collaborator 598148.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Hsueh, Shih-Chang; Chen, Kai-Yun; Lai, Jing-Huei; Wu, Chung-Che; Yu, Yu-Wen; Luo, Yu; Hsieh, Tsung-Hsun; Chiang, Yung-Hsiao (2018. ) Voluntary Physical Exercise Improves Subsequent Motor and Cognitive Impairments in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , 19 (2 ) , More Information

Kim, Dong Seok; Choi, Ho-Il; Wang, Yun; Luo, Yu; Hoffer, Barry J; Greig, Nigel H (2017. ) A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway.Cell transplantation, , 26 (9 ) ,1560-1571 More Information

Lu, Tao; Kim, Paul P; Greig, Nigel H; Luo, Yu (2017. ) Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity.Neurotoxicity research, , 32 (2 ) ,218-230 More Information

Jin, Yongming; Barnett, Austin; Zhang, Yifan; Yu, Xin; Luo, Yu (2017. ) Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis.Stroke, , 48 (6 ) ,1636-1645 More Information

Yang, Ling-Yu; Greig, Nigel H; Huang, Ya-Ni; Hsieh, Tsung-Hsun; Tweedie, David; Yu, Qian-Sheng; Hoffer, Barry J; Luo, Yu; Kao, Yu-Chieh; Wang, Jia-Yi (2016. ) Post-traumatic administration of the p53 inactivator pifithrin-O oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.Neurobiology of disease, , 96 ,216-226 More Information

Filichia, Emily; Hoffer, Barry; Qi, Xin; Luo, Yu (2016. ) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP.Scientific reports, , 6 ,32656 More Information

Zhou, Xiaofei; Pace, Jonathan; Filichia, Emily; Lv, Tao; Davis, Brandon; Hoffer, Barry; Selman, Warren; Luo, Yu (2016. ) Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons.Experimental neurology, , 283 (Pt A ) ,235-45 More Information

Qi, Xin; Davis, Brandon; Chiang, Yung-Hsiao; Filichia, Emily; Barnett, Austin; Greig, Nigel H; Hoffer, Barry; Luo, Yu (2016. ) Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model.Journal of neurochemistry, , 138 (5 ) ,746-57 More Information

Guo, Xing; Sun, XiaoYan; Hu, Di; Wang, Ya-Juan; Fujioka, Hisashi; Vyas, Rajan; Chakrapani, Sudha; Joshi, Amit Umesh; Luo, Yu; Mochly-Rosen, Daria; Qi, Xin (2016. ) VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.Nature communications, , 7 ,12646 More Information

Wang, Jin-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi (2016. ) Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.Journal of neuroinflammation, , 13 (1 ) ,168 More Information

Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry; Luo, Yu (2016. ) Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.Brain and behavior, , 6 (8 ) ,e00491 More Information

Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry J; Luo, Yu (2016. ) Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.The American journal of psychiatry, , 173 (4 ) ,429-31 More Information

Liu, H-S; Shen, H; Luo, Y; Hoffer, B J; Wang, Y; Yang, Y (2016. ) Post-treatment with cocaine- and amphetamine-regulated transcript enhances infarct resolution, reinnervation, and angiogenesis in stroke rats - an MRI study.NMR in biomedicine, , 29 (3 ) ,361-70 More Information

Luo, Yu; Hoffer, Alan; Hoffer, Barry; Qi, Xin (2015. ) Mitochondria: A Therapeutic Target for Parkinson's Disease?.International journal of molecular sciences, , 16 (9 ) ,20704-30 More Information

Yu Luo, Hui Shen, Hua‐Shan Liu, Seong‐Jin Yu, David Reiner, Brandon K. Harvey, Barry J. Hoffer, Yihong Yang, and Yun Wang (2013. ) CART peptide induces neuroregeneration in stroke rats .Journal of Cerebral Blood Flow and Metabolism , , 33 (2 ) ,300-10

Filichia, E; Shen, H; Zhou, X; Qi, X; Jin, K; Greig, N; Hoffer, B; Luo, Y (2015. ) Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.Neuroscience, , 295 ,1-10 More Information

Yu Luo, Chi-Chung Kuo, Hui Shen, Jenny Chou, Nigel H. Greig, Barry J. Hoffer, Yun Wang (2009. ) Delayed treatment with a p53 inhibitor enhances functional recovery in stroke brain .Ann Neurol, , 65 (5 ) ,520-30

Jin, Yongmin; Raviv, Nataly; Barnett, Austin; Bambakidis, Nicholas C; Filichia, Emily; Luo, Yu (2015. ) The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model.PloS one, , 10 (4 ) ,e0124657 More Information

Yu Luo, Feng Xing, Rita Guiliano, Howard J. Federoff (2008. ) Identification of a novel Nurr1 interacting protein .J Neurosci, , 28 (37 ) , 9277-86

Yu Luo, Leigh A. Henricksen, Rita E. Giuliano, Landa Prifti, Linda M. Callahan and Howard J. Federoff (2007. ) VIP is a transcriptional target of Nurr1 in dopaminergic cells .Experimental Neurology, , 203 (1 ) ,221-232

Gu, Yuning; Gao, Huiyun; Kim, Kihwan; Liu, Yuchi; Ramos-Estebanez, Ciro; Luo, Yu; Wang, Yunmei; Yu, Xin (2021. ) Dynamic oxygen-17 MRI with adaptive temporal resolution using golden-means-based 3D radial sampling.Magnetic resonance in medicine, , 85 (6 ) ,3112-3124 More Information

Luo, Fucheng; Zhang, Zhen; Barnett, Austin; Bellinger, Tania J; Turcato, Flavia; Schmidt, Kelly; Luo, Yu (2020. ) Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain.Experimental neurology, , 326 ,113168 More Information

Flavia Turcato, Paul Kim, Austin Barnett, Yongming Jin, Mike Scerba, Anthony Casey, Warren Selman, Nigel H. Greig, and Yu Luo (2018. ) Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke .Cell Transplantation, ,

Hu, Di; Sun, Xiaoyan; Liao, Xudong; Zhang, Xinwen; Zarabi, Sara; Schimmer, Aaron; Hong, Yuning; Ford, Christopher; Luo, Yu; Qi, Xin (2019. ) Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.Acta neuropathologica, , 137 (6 ) ,939-960 More Information

Glotfelty, Elliot J; Delgado, Thomas; Tovar-Y-Romo, Luis B; Luo, Yu; Hoffer, Barry; Olson, Lars; Karlsson, Tobias; Mattson, Mark P; Harvey, Brandon; Tweedie, David; Li, Yazhou; Greig, Nigel H (2019. ) Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury.ACS pharmacology & translational science, , 2 (2 ) ,66-91 More Information

Turcato, Flavia; Kim, Paul; Barnett, Austin; Jin, Yongming; Scerba, Mike; Casey, Anthony; Selman, Warren; Greig, Nigel H; Luo, Yu (2018. ) Sequential combined Treatment of Pifithrin-? and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke.Cell transplantation, , 27 (4 ) ,607-621 More Information

Chang, Cheng-Fu; Lai, Jing-Huei; Wu, John Chung-Che; Greig, Nigel H; Becker, Robert E; Luo, Yu; Chen, Yen-Hua; Kang, Shuo-Jhen; Chiang, Yung-Hsiao; Chen, Kai-Yun (2017. ) (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury.Brain research, , 1677 ,118-128 More Information

Lu, Tao; Kim, Paul; Luo, Yu (2017. ) Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models.Neural regeneration research, , 12 (9 ) ,1413-1417 More Information

Xu, Kui; Ye, Lena; Sharma, Katyayini; Jin, Yongming; Harrison, Matthew M; Caldwell, Tylor; Berthiaume, Jessica M; Luo, Yu; LaManna, Joseph C; Puchowicz, Michelle A (2017. ) Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse.Advances in experimental medicine and biology, , 977 ,205-213 More Information

Wang, Jing-Ya; Huang, Ya-Ni; Chiu, Chong-Chi; Tweedie, David; Luo, Weiming; Pick, Chaim G; Chou, Szu-Yi; Luo, Yu; Hoffer, Barry J; Greig, Nigel H; Wang, Jia-Yi (2016. ) Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.Journal of neuroinflammation, , 13 (1 ) ,228 More Information

Tweedie, David; Fukui, Koji; Li, Yazhou; Yu, Qian-Sheng; Barak, Shani; Tamargo, Ian A; Rubovitch, Vardit; Holloway, Harold W; Lehrmann, Elin; Wood, William H; Zhang, Yongqing; Becker, Kevin G; Perez, Evelyn; Van Praag, Henriette; Luo, Yu; Hoffer, Barry J; Becker, Robert E; Pick, Chaim G; Greig, Nigel H (2016. ) Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms.PloS one, , 11 (6 ) ,e0156493 More Information

Luo, Yu (2012. ) The function and mechanisms of Nurr1 action in midbrain dopaminergic neurons, from development and maintenance to survival.International review of neurobiology, , 102 ,1-22 More Information

Luo, Y; Neet, K E (1992. ) The unprocessed C-terminal dipeptide of recombinant beta-nerve growth factor determines three stable forms with distinct biological activities. The Journal of biological chemistry, , 267 (17 ) ,12275-83

Invited Publications

Yu Luo (2011. ) Cell-based therapy for stroke .Journal of Neurotransmission, 118 (1 ) ,61-74

Yu Luo, Serena Y Kuang, Barry Hoffer (2009. ) How useful are stem cells in PD therapy? .Parkinson’s disease and Related Disorders, 15 (3 ) ,S171-S175

Yu Luo (2012. ) The function and mechanisms of nurr1 action in midbrain dopaminergic neurons, from development and maintenance to survival .Int Rev Neurobiol, (102 ) ,1-22

Yu Luo; Alan Hoffer; Barry Hoffer; Xin Qi . (2015. ) Mitochondria: a therapeutic target for Parkinson’s disease? .Int. J. Mol. Sci., 16 (9 ) ,20704–20730

Book Chapter

Kui Xu, Lena Ye, Katyayini Sharma, Yongming Jin, Matthew M Harrison, Tylor Caldwell, Jessica M Berthiaume, Yu Luo, Joseph C LaManna, Michelle A Puchowicz. (2017 ) Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse Advances in Experimental Medicine and Biology Book Serials: Oxygen Transport to Tissue XXXIX .

Fucheng Luo and Yu Luo (2017 ) Modulating endogenous neural stem cells to improve regeneration in stroke brain. Springer Series in Translational Stroke Research: “Translational Stroke Research –Cellular and Molecular Approaches to Regeneration & Repair.” .Springer

Encyclopedia Article

Yu Luo, Barry, J. Hoffer, Yun Wang (2010. ) Encyclopedia of Movement Disorders .Elsevier Publish

Contact Information

Academic - 2256 Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-1188
Fax: 513-558-5604
luoy2@ucmail.uc.edu