Richard Lu, PhD

Research in the Lu Lab aims to understand how distinct glial cell subtypes (oligodendrocytes, astrocytes and Schwann cells) in the central and peripheral nervous systems are generated, how they are regenerated after injury, and how their progenitors are transformed into cancerous cells under pathological conditions.

https://www.cincinnatichildrens.org/research/divisions/e/ex-hem/labs/lu

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Developmental Biology

Peer Reviewed Publications

Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi  (2022). Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 (2) , 111072More Information

Yi, Jiaqing; Kim, BongWoo; Shi, Xuanming; Zhan, Xiaoming; Lu, Q Richard; Xuan, Zhenyu; Wu, Jiang  (2022). PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer researchMore Information

Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Shah, Sanjit; Woo, Daniel; Lamba, Michael; Plas, David R; Paranjpe, Aditi; Roskin, Krishna; Zhao, Chuntao; Lu, Richard  (2022). Chromatin structure predicts survival in glioma patients. Scientific reports, 12 (1) , 8221More Information

Zhang, Jing; Guan, Menglong; Zhou, Xianyao; Berry, Kalen; He, Xuelian; Lu, Q Richard  (2022). Long Noncoding RNAs in CNS Myelination and Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 10738584221083919More Information

Rao, Rohit; Han, Rong; Ogurek, Sean; Xue, Chengbin; Wu, Lai Man; Zhang, Liguo; Zhang, Li; Hu, Jian; Phoenix, Timothy N; Waggoner, Stephen N; Lu, Q Richard  (2022). Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-oncology, 24 (4) , 584-597More Information

Del Águila, Ángela; Adam, Mike; Ullom, Kristy; Shaw, Nicholas; Qin, Shenyue; Ehrman, Jacqueline; Nardini, Diana; Salomone, Joseph; Gebelein, Brian; Lu, Q Richard; Potter, Steven S; Waclaw, Ronald; Campbell, Kenneth; Nakafuku, Masato  (2022). Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge, England), 149 (5) More Information

Guo, Duancheng; Wang, Yuan; Cheng, Yan; Liao, Shengyou; Hu, Jian; Du, Fang; Xu, Gang; Liu, Yongqiang; Cai, Kathy Q; Cheung, Martin; Wainwright, Brandon J; Lu, Q Richard; Zhao, Yi; Yang, Zeng-Jie  (2021). Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. The Journal of experimental medicine, 218 (9) More Information

Zhang, Ming; Wang, Jian; Zhang, Kaixiang; Lu, Guozhen; Liu, Yuming; Ren, Keke; Wang, Wenting; Xin, Dazhuan; Xu, Lingli; Mao, Honghui; Xing, Junlin; Gao, Xingchun; Jin, Weilin; Berry, Kalen; Mikoshiba, Katsuhiko; Wu, Shengxi; Lu, Q Richard; Zhao, Xianghui  (2021). Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature communications, 12 (1) , 5091More Information

Geraldo, Luiz H; Xu, Yunling; Jacob, Laurent; Pibouin-Fragner, Laurence; Rao, Rohit; Maissa, Nawal; Verreault, Maïté; Lemaire, Nolwenn; Knosp, Camille; Lesaffre, Corinne; Daubon, Thomas; Dejaegher, Joost; Solie, Lien; Rudewicz, Justine; Viel, Thomas; Tavitian, Bertrand; De Vleeschouwer, Steven; Sanson, Marc; Bikfalvi, Andreas; Idbaih, Ahmed; Lu, Q Richard; Lima, Flavia Rs; Thomas, Jean-Leon; Eichmann, Anne; Mathivet, Thomas  (2021). SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. The Journal of clinical investigation, 131 (16) More Information

Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi  (2021). The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 (3) , 221-233More Information

Luo, Zaili; Dong, Xinran; Yu, Jianzhong; Xia, Yong; Berry, Kalen P; Rao, Rohit; Xu, Lingli; Xue, Ping; Chen, Tong; Lin, Yifeng; Yu, Jiyang; Huang, Guoying; Li, Hao; Zhou, Wenhao; Lu, Q Richard  (2021). Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in cell and developmental biology, 9, 634056More Information

Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi  (2021). Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 (1) More Information

Wang, Jing; He, Xuelian; Meng, Huyan; Li, Yi; Dmitriev, Phillip; Tian, Feng; Page, Jessica C; Lu, Q Richard; He, Zhigang  (2020). Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron, 108 (5) , 876-886.e4More Information

Althoff, Mark J; Nayak, Ramesh C; Hegde, Shailaja; Wellendorf, Ashley M; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Q Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A  (2020). Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, 136 (16) , 1824-1836More Information

Wang, Jiajia; Lu, Q Richard  (2020). Convergent epigenetic regulation of glial plasticity in myelin repair and brain tumorigenesis: A focus on histone modifying enzymes. Neurobiology of disease, 144, 105040More Information

Wang, Jincheng; Wang, Jiajia; Yang, Lijun; Zhao, Chuntao; Wu, Laiman Natalie; Xu, Lingli; Zhang, Feng; Weng, Qinjie; Wegner, Michael; Lu, Q Richard  (2020). CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature communications, 11 (1) , 4133More Information

Wang, Jiajia; Yang, Lijun; Dong, Chen; Wang, Jincheng; Xu, Lingli; Qiu, Yueping; Weng, Qinjie; Zhao, Chuntao; Xin, Mei; Lu, Q Richard  (2020). EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science advances, 6 (33) , eaaz6477More Information

Berry, Kalen; Wang, Jiajia; Lu, Q Richard  (2020). Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases. F1000Research, 9More Information

Weng, Qinjie; Wang, Jiaying; Wang, Jiajia; Wang, Jing; Sattar, Fahmida; Zhang, Zhikang; Zheng, Jiahuan; Xu, Zijie; Zhao, Mengting; Liu, Xuan; Yang, Lijun; Hao, Guifeng; Fang, Liang; Lu, Q Richard; Yang, Bo; He, Qiaojun  (2020). Correction: Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell death & disease, 11 (2) , 108More Information

Weng, Qinjie; Zhao, Mengting; Zheng, Jiahuan; Yang, Lijun; Xu, Zijie; Zhang, Zhikang; Wang, Jincheng; Wang, Jiajia; Yang, Bo; Richard Lu, Q; Ying, Meidan; He, Qiaojun  (2020). STAT3 dictates ?-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation, 27 (1) , 130-145More Information

Berry, Kalen P; Lu, Q Richard  (2020). Chromatin modification and epigenetic control in functional nerve regeneration. Seminars in cell & developmental biology, 97, 74-83More Information

Zhang, Liguo; He, Xuelian; Liu, Xuezhao; Zhang, Feng; Huang, L Frank; Potter, Andrew S; Xu, Lingli; Zhou, Wenhao; Zheng, Tao; Luo, Zaili; Berry, Kalen P; Pribnow, Allison; Smith, Stephanie M; Fuller, Christine; Jones, Blaise V; Fouladi, Maryam; Drissi, Rachid; Yang, Zeng-Jie; Gustafson, W Clay; Remke, Marc; Pomeroy, Scott L; Girard, Emily J; Olson, James M; Morrissy, A Sorana; Vladoiu, Maria C; Zhang, Jiao; Tian, Weidong; Xin, Mei; Taylor, Michael D; Potter, S Steven; Roussel, Martine F; Weiss, William A; Lu, Q Richard  (2019). Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer cell, 36 (3) , 302-318.e7More Information

Boshans, Linda L; Factor, Daniel C; Singh, Vijender; Liu, Jia; Zhao, Chuntao; Mandoiu, Ion; Lu, Q Richard; Casaccia, Patrizia; Tesar, Paul J; Nishiyama, Akiko  (2019). The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in neuroscience, 13, 829More Information

Lu, Q Richard; Qian, Lily; Zhou, Xianyao  (2019). Developmental origins and oncogenic pathways in malignant brain tumors. Wiley interdisciplinary reviews. Developmental biology, 8 (4) , e342More Information

Weng, Qinjie; Wang, Jincheng; Wang, Jiajia; He, Danyang; Cheng, Zuolin; Zhang, Feng; Verma, Ravinder; Xu, Lingli; Dong, Xinran; Liao, Yunfei; He, Xuelian; Potter, Andrew; Zhang, Liguo; Zhao, Chuntao; Xin, Mei; Zhou, Qian; Aronow, Bruce J; Blackshear, Perry J; Rich, Jeremy N; He, Qiaojun; Zhou, Wenhao; Suvà, Mario L; Waclaw, Ronald R; Potter, S Steven; Yu, Guoqiang; Lu, Q Richard  (2019). Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell stem cell, 24 (5) , 707-723.e8More Information

Hall, Ashley; Choi, Kwangmin; Liu, Wei; Rose, Jonathan; Zhao, Chuntao; Yu, Yanan; Na, Youjin; Cai, Yuqi; Coover, Robert A; Lin, Yi; Dombi, Eva; Kim, MiOk; Levanon, Ditsa; Groner, Yoram; Boscolo, Elisa; Pan, Dao; Liu, P Paul; Lu, Q Richard; Ratner, Nancy; Huang, Gang; Wu, Jianqiang  (2019). RUNX represses Pmp22 to drive neurofibromagenesis. Science advances, 5 (4) , eaau8389More Information

Ou, Zhimin; Ma, Yanchen; Sun, Yuxia; Zheng, Gege; Wang, Shiyun; Xing, Rui; Chen, Xiang; Han, Ying; Wang, Jiajia; Lu, Q Richard; Zhao, Tong-Jin; Chen, Ying  (2019). A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell reports, 26 (11) , 2984-2997.e4More Information

Yang, Lin; Kong, Yanting; Dong, Xinran; Hu, Liyuan; Lin, Yifeng; Chen, Xiang; Ni, Qi; Lu, Yulan; Wu, Bingbing; Wang, Huijun; Lu, Q Richard; Zhou, Wenhao  (2019). Clinical and genetic spectrum of a large cohort of children with epilepsy in China. Genetics in medicine : official journal of the American College of Medical Genetics, 21 (3) , 564-571More Information

Jiang, Minqing; Rao, Rohit; Wang, Jincheng; Wang, Jiajia; Xu, Lingli; Wu, Lai Man; Chan, Jonah R; Wang, Huimin; Lu, Q Richard  (2018). The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner. Glia, 66 (9) , 1947-1959More Information

Marie, Corentine; Clavairoly, Adrien; Frah, Magali; Hmidan, Hatem; Yan, Jun; Zhao, Chuntao; Van Steenwinckel, Juliette; Daveau, Romain; Zalc, Bernard; Hassan, Bassem; Thomas, Jean-Léon; Gressens, Pierre; Ravassard, Philippe; Moszer, Ivan; Martin, Donna M; Lu, Q Richard; Parras, Carlos  (2018). Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8. Proceedings of the National Academy of Sciences of the United States of America, 115 (35) , E8246-E8255More Information

Zhao, Chuntao; Dong, Chen; Frah, Magali; Deng, Yaqi; Marie, Corentine; Zhang, Feng; Xu, Lingli; Ma, Zhixing; Dong, Xinran; Lin, Yifeng; Koenig, Scott; Nait-Oumesmar, Brahim; Martin, Donna M; Wu, Laiman N; Xin, Mei; Zhou, Wenhao; Parras, Carlos; Lu, Q Richard  (2018). Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Developmental cell, 45 (6) , 753-768.e8More Information

Moyano, Ana Lis; Steplowski, Jeffrey; Wang, Haibo; Son, Kyung-No; Rapolti, Diana I; Marshall, Jeffrey; Elackattu, Vince; Marshall, Michael S; Hebert, Amy K; Reiter, Cory R; Ulloa, Viviana; Pituch, Katarzyna C; Givogri, Maria I; Lu, Q Richard; Lipton, Howard L; Bongarzone, Ernesto R  (2018). microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease. Molecular therapy : the journal of the American Society of Gene Therapy, 26 (3) , 730-743More Information

Koreman, Elijah; Sun, Xiaowei; Lu, Q Richard  (2018). Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair. Molecular and cellular neurosciences, 87, 18-26More Information

He, Xuelian; Zhang, Liguo; Queme, Luis F; Liu, Xuezhao; Lu, Andrew; Waclaw, Ronald R; Dong, Xinran; Zhou, Wenhao; Kidd, Grahame; Yoon, Sung-Ok; Buonanno, Andres; Rubin, Joshua B; Xin, Mei; Nave, Klaus-Armin; Trapp, Bruce D; Jankowski, Michael P; Lu, Q Richard  (2018). A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature medicine, 24 (3) , 338-351More Information

Zuo, Hao; Wood, William M; Sherafat, Amin; Hill, Robert A; Lu, Q Richard; Nishiyama, Akiko  (2018). Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 (9) , 2359-2371More Information

Weng, Qinjie; Wang, Jiaying; Wang, Jiajia; Wang, Jing; Sattar, Fahmida; Zhang, Zhikang; Zheng, Jiahuan; Xu, Zijie; Zhao, Mengting; Liu, Xuan; Yang, Lijun; Hao, Guifeng; Fang, Liang; Lu, Q Richard; Yang, Bo; He, Qiaojun  (2018). Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell death & disease, 9 (2) , 251More Information

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard  (2018). Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 (2) , 292-308.e7More Information

He, Li; Yu, Kun; Lu, Fanghui; Wang, Jiajia; Wu, Laiman N; Zhao, Chuntao; Li, Qianmei; Zhou, Xianyao; Liu, Hanmin; Mu, Dezhi; Xin, Mei; Qiu, Mengsheng; Lu, Q Richard  (2018). Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 (6) , 1575-1587More Information

Li, Zhuo; Peng, Yanyan; Hufnagel, Robert B; Hu, Yueh-Chiang; Zhao, Chuntao; Queme, Luis F; Khuchua, Zaza; Driver, Ashley M; Dong, Fei; Lu, Q Richard; Lindquist, Diana M; Jankowski, Michael P; Stottmann, Rolf W; Kao, Winston W Y; Huang, Taosheng  (2017). Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice. Human molecular genetics, 26 (19) , 3776-3791More Information

Kosty, Jennifer; Lu, Fanghui; Kupp, Robert; Mehta, Shwetal; Lu, Q Richard  (2017). Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas. Cell cycle (Georgetown, Tex.), 16 (18) , 1654-1660More Information

Weng, Qinjie; Wang, Jiajia; Wang, Jiaying; Tan, Biqin; Wang, Jing; Wang, Haibo; Zheng, Tao; Lu, Q Richard; Yang, Bo; He, Qiaojun  (2017). Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPK? Activity. Scientific reports, 7 (1) , 1705More Information

Deng, Yaqi; Wu, Lai Man Natalie; Bai, Shujun; Zhao, Chuntao; Wang, Haibo; Wang, Jincheng; Xu, Lingli; Sakabe, Masahide; Zhou, Wenhao; Xin, Mei; Lu, Q Richard  (2017). A reciprocal regulatory loop between TAZ/YAP and G-protein G?s regulates Schwann cell proliferation and myelination. Nature communications, 8, 15161More Information

Wang, Haibo; Moyano, Ana Lis; Ma, Zhangyan; Deng, Yaqi; Lin, Yifeng; Zhao, Chuntao; Zhang, Liguo; Jiang, Minqing; He, Xuelian; Ma, Zhixing; Lu, Fanghui; Xin, Mei; Zhou, Wenhao; Yoon, Sung Ok; Bongarzone, Ernesto R; Lu, Q Richard  (2017). miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS. Developmental cell, 40 (6) , 566-582.e5More Information

Qu, Yi; Tang, Jun; Wang, Huiqing; Li, Shiping; Zhao, Fengyan; Zhang, Li; Richard Lu, Q; Mu, Dezhi  (2017). RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain. Cell death & disease, 8 (2) , e2629More Information

He, Danyang; Wang, Jincheng; Lu, Yulan; Deng, Yaqi; Zhao, Chuntao; Xu, Lingli; Chen, Yinhuai; Hu, Yueh-Chiang; Zhou, Wenhao; Lu, Q Richard  (2017). lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron, 93 (2) , 362-378More Information

Ou, Zhimin; Sun, Yuxia; Lin, Li; You, Nachun; Liu, Xue; Li, Hongchao; Ma, Yanchen; Cao, Lei; Han, Ying; Liu, Min; Deng, Yaqi; Yao, Luming; Lu, Q Richard; Chen, Ying  (2016). Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 (41) , 10560-10573More Information

Wu, Lai Man Natalie; Wang, Jincheng; Conidi, Andrea; Zhao, Chuntao; Wang, Haibo; Ford, Zachary; Zhang, Liguo; Zweier, Christiane; Ayee, Brian G; Maurel, Patrice; Zwijsen, An; Chan, Jonah R; Jankowski, Michael P; Huylebroeck, Danny; Lu, Q Richard  (2016). Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nature neuroscience, 19 (8) , 1060-72More Information

Ju, Jun; Liu, Qian; Zhang, Yang; Liu, Yuanxiu; Jiang, Mei; Zhang, Liguo; He, Xuelian; Peng, Chenchen; Zheng, Tao; Lu, Q Richard; Li, Hedong  (2016). Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Scientific reports, 6, 30711More Information

Jiang, Minqing; Liu, Lei; He, Xuelian; Wang, Haibo; Lin, Wensheng; Wang, Huimin; Yoon, Sung O; Wood, Teresa L; Lu, Q Richard  (2016). Regulation of PERK-eIF2? signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nature communications, 7, 12185More Information

Steelman, Andrew J; Zhou, Yun; Koito, Hisami; Kim, SunJa; Payne, H Ross; Lu, Q Richard; Li, Jianrong  (2016). Activation of oligodendroglial Stat3 is required for efficient remyelination. Neurobiology of disease, 91, 336-46More Information

Dries, Daniel R; Zhu, Yi; Brooks, Mieu M; Forero, Diego A; Adachi, Megumi; Cenik, Basar; West, James M; Han, Yu-Hong; Yu, Cong; Arbella, Jennifer; Nordin, Annelie; Adolfsson, Rolf; Del-Favero, Jurgen; Lu, Q Richard; Callaerts, Patrick; Birnbaum, Shari G; Yu, Gang  (2016). Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior. The Journal of biological chemistry, 291 (22) , 11647-56More Information

Laitman, Benjamin M; Asp, Linnéa; Mariani, John N; Zhang, Jingya; Liu, Jia; Sawai, Setsu; Chapouly, Candice; Horng, Sam; Kramer, Elisabeth G; Mitiku, Nesanet; Loo, Hannah; Burlant, Natalie; Pedre, Xiomara; Hara, Yuko; Nudelman, German; Zaslavsky, Elena; Lee, Young-Min; Braun, David A; Lu, Q Richard; Narla, Goutham; Raine, Cedric S; Friedman, Scott L; Casaccia, Patrizia; John, Gareth R  (2016). The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS biology, 14 (5) , e1002467More Information

Rao, Rohit; Salloum, Ralph; Xin, Mei; Lu, Q Richard  (2016). The G protein G?s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis. Cell cycle (Georgetown, Tex.), 15 (10) , 1325-30More Information

Lu, Fanghui; Chen, Ying; Zhao, Chuntao; Wang, Haibo; He, Danyang; Xu, Lingli; Wang, Jincheng; He, Xuelian; Deng, Yaqi; Lu, Ellen E; Liu, Xue; Verma, Ravinder; Bu, Hong; Drissi, Rachid; Fouladi, Maryam; Stemmer-Rachamimov, Anat O; Burns, Dennis; Xin, Mei; Rubin, Joshua B; Bahassi, El Mustapha; Canoll, Peter; Holland, Eric C; Lu, Q Richard  (2016). Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer cell, 29 (5) , 669-683More Information

Lopez Juarez, Alejandro; He, Danyang; Richard Lu, Q  (2016). Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration. Brain research, 1638 (Pt B) , 209-220More Information

He, Danyang; Marie, Corentine; Zhao, Chuntao; Kim, Bongwoo; Wang, Jincheng; Deng, Yaqi; Clavairoly, Adrien; Frah, Magali; Wang, Haibo; He, Xuelian; Hmidan, Hatem; Jones, Blaise V; Witte, David; Zalc, Bernard; Zhou, Xin; Choo, Daniel I; Martin, Donna M; Parras, Carlos; Lu, Q Richard  (2016). Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nature neuroscience, 19 (5) , 678-689More Information

Zhao, Chuntao; Deng, Yaqi; Liu, Lei; Yu, Kun; Zhang, Liguo; Wang, Haibo; He, Xuelian; Wang, Jincheng; Lu, Changqing; Wu, Laiman N; Weng, Qinjie; Mao, Meng; Li, Jianrong; van Es, Johan H; Xin, Mei; Parry, Lee; Goldman, Steven A; Clevers, Hans; Lu, Q Richard  (2016). Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature communications, 7, 10883More Information

Hoffman, Lindsey M; DeWire, Mariko; Ryall, Scott; Buczkowicz, Pawel; Leach, James; Miles, Lili; Ramani, Arun K; Brudno, Michael; Kumar, Shiva Senthil; Drissi, Rachid; Dexheimer, Phillip; Salloum, Ralph; Chow, Lionel; Hummel, Trent; Stevenson, Charles; Lu, Q Richard; Jones, Blaise; Witte, David; Aronow, Bruce; Hawkins, Cynthia E; Fouladi, Maryam  (2016). Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta neuropathologica communications, 4, 13More Information

Zhang, Liguo; He, Xuelian; Liu, Lei; Jiang, Minqing; Zhao, Chuntao; Wang, Haibo; He, Danyang; Zheng, Tao; Zhou, Xianyao; Hassan, Aishlin; Ma, Zhixing; Xin, Mei; Sun, Zheng; Lazar, Mitchell A; Goldman, Steven A; Olson, Eric N; Lu, Q Richard  (2016). Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental cell, 36 (3) , 316-30More Information

Hoffman, Lindsey M; DeWire, Mariko; Ryall, Scott; Buczkowicz, Pawel; Leach, James; Miles, Lili; Ramani, Arun; Brudno, Michael; Kumar, Shiva Senthil; Drissi, Rachid; Dexheimer, Phillip; Salloum, Ralph; Chow, Lionel; Hummel, Trent; Stevenson, Charles; Lu, Q Richard; Jones, Blaise; Witte, David; Aronow, Bruce; Hawkins, Cynthia E; Fouladi, Maryam  (2016). Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta neuropathologica communications, 4, 1More Information

Diao, Hua Jia; Low, Wei Ching; Lu, Q Richard; Chew, Sing Yian  (2015). Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development. Biomaterials, 70, 105-14More Information

Gururangan, Sridharan; Robinson, Giles; Ellison, David W; Wu, Gang; He, Xuelian; Lu, Q Richard; McLendon, Roger; Grant, Gerald; Driscoll, Timothy; Neuberg, Ronnie  (2015). Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations. Pediatric blood & cancer, 62 (10) , 1855-8More Information

Emery, Ben; Lu, Q Richard  (2015). Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System. Cold Spring Harbor perspectives in biology, 7 (9) , a020461More Information

Diao, Hua Jia; Low, Wei Ching; Milbreta, Ulla; Lu, Q Richard; Chew, Sing Yian  (2015). Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. Journal of controlled release : official journal of the Controlled Release Society, 208, 85-92More Information

Liu, Wei; Zhou, Hui; Liu, Lei; Zhao, Chuntao; Deng, Yaqi; Chen, Lina; Wu, Laiman; Mandrycky, Nicole; McNabb, Christopher T; Peng, Yuanbo; Fuchs, Perry N; Lu, Jie; Sheen, Volney; Qiu, Mengsheng; Mao, Meng; Lu, Q Richard  (2015). Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region. Neurobiology of disease, 77, 106-16More Information

He, Xuelian; Lu, Q RichardG-Protein G?s controls medulloblastoma initiation by suppressing sonic hedgehog signaling. Molecular & cellular oncology, 2 (2) , e975070More Information

Shen, Yun-An A; Chen, Yan; Dao, Dang Q; Mayoral, Sonia R; Wu, Laiman; Meijer, Dies; Ullian, Erik M; Chan, Jonah R; Lu, Q Richard  (2014). Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nature communications, 5, 4991More Information

He, Xuelian; Zhang, Liguo; Chen, Ying; Remke, Marc; Shih, David; Lu, Fanghui; Wang, Haibo; Deng, Yaqi; Yu, Yang; Xia, Yong; Wu, Xiaochong; Ramaswamy, Vijay; Hu, Tom; Wang, Fan; Zhou, Wenhao; Burns, Dennis K; Kim, Se Hoon; Kool, Marcel; Pfister, Stefan M; Weinstein, Lee S; Pomeroy, Scott L; Gilbertson, Richard J; Rubin, Joshua B; Hou, Yiping; Wechsler-Reya, Robert; Taylor, Michael D; Lu, Q Richard  (2014). The G protein ? subunit G?s is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature medicine, 20 (9) , 1035-42More Information

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