Carolyn Lutzko

Peer Reviewed Publications

Tsai, Steven C; Chang, David F; Hong, Chang-Mu; Xia, Ping; Senadheera, Dinithi; Trump, Lisa; Mishra, Suparna; Lutzko, Carolyn  (2014). Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency. American journal of physiology. Cell physiology, 306 (12) , C1108-18More Information

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S  (2014). Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms. Blood, 123 (4) , 562-9More Information

Weiss, Daniel J; Bates, Jason H T; Gilbert, Thomas; Liles, W Conrad; Lutzko, Carolyn; Rajagopal, Jay; Prockop, Darwin  (2013). Stem cells and cell therapies in lung biology and diseases: conference report. Annals of the American Thoracic Society, 10 (5) , S25-44More Information

Chen, Leiling; Acciani, Thomas; Le Cras, Tim; Lutzko, Carolyn; Perl, Anne-Karina T  (2012). Dynamic regulation of platelet-derived growth factor receptor ? expression in alveolar fibroblasts during realveolarization. American journal of respiratory cell and molecular biology, 47 (4) , 517-27More Information

Hasegawa, Kouichi; Yasuda, Shin-ya; Teo, Jia-Ling; Nguyen, Cu; McMillan, Michael; Hsieh, Chih-Lin; Suemori, Hirofumi; Nakatsuji, Norio; Yamamoto, Masashi; Miyabayashi, Tomoyuki; Lutzko, Carolyn; Pera, Martin F; Kahn, Michael  (2012). Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem cells translational medicine, 1 (1) , 18-28More Information

Mishra, Suparna; Wang, Xingchao; Smiley, Nancy; Xia, Ping; Hong, Chang Mu; Senadheera, Dinithi; Bui, Kim Chi; Lutzko, Carolyn  (2011). Genetic modification of airway progenitors after lentiviral gene delivery to the amniotic fluid of murine fetuses. American journal of respiratory cell and molecular biology, 44 (4) , 562-70More Information

Bui, Kim Chi T; Senadheera, Dinithi; Wang, Xingchao; Hendrickson, Benjamin; Friedlich, Philippe; Lutzko, Carolyn  (2010). Recovery of multipotent progenitors from the peripheral blood of patients requiring extracorporeal membrane oxygenation support. American journal of respiratory and critical care medicine, 181 (3) , 226-37More Information

Jiang, Xiaohua; Gwye, Ynnez; McKeown, Sonja J; Bronner-Fraser, Marianne; Lutzko, Carolyn; Lawlor, Elizabeth R  (2009). Isolation and characterization of neural crest stem cells derived from in vitro-differentiated human embryonic stem cells. Stem cells and development, 18 (7) , 1059-70More Information

Harb, Rula; Xie, Guanhua; Lutzko, Carolyn; Guo, Yumei; Wang, Xiangdong; Hill, Colin K; Kanel, Gary C; DeLeve, Laurie D  (2009). Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology, 137 (2) , 704-12More Information

Chang, David F; Tsai, Steven C; Wang, Xing Chao; Xia, Ping; Senadheera, Dinithi; Lutzko, Carolyn  (2009). Molecular characterization of the human NANOG protein. Stem cells (Dayton, Ohio), 27 (4) , 812-21More Information

Liebler, Janice M; Lutzko, Carolyn; Banfalvi, Agnes; Senadheera, Dinithi; Aghamohammadi, Neema; Crandall, Edward D; Borok, Zea  (2008). Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. American journal of physiology. Lung cellular and molecular physiology, 295 (2) , L285-92More Information

Melchior, Kai; Weiss, Jonathan; Zaehres, Holm; Kim, Yong-mi; Lutzko, Carolyn; Roosta, Neda; Hescheler, Jürgen; Müschen, Markus  (2008). The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biological chemistry, 389 (7) , 897-903More Information

Rodriguez, Ryan T; Velkey, J Matthew; Lutzko, Carolyn; Seerke, Rina; Kohn, Donald B; O'Shea, K Sue; Firpo, Meri T  (2007). Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. Experimental biology and medicine (Maywood, N.J.), 232 (10) , 1368-80More Information

Hendrickson, Benjamin; Senadheera, Dinithi; Mishra, Suparna; Bui, Kim Chi T; Wang, Xingchao; Chan, Belinda; Petersen, Denise; Pepper, Karen; Lutzko, Carolyn  (2007). Development of lentiviral vectors with regulated respiratory epithelial expression in vivo. American journal of respiratory cell and molecular biology, 37 (4) , 414-23More Information

Jang, Jung-Eun; Shaw, Kit; Yu, Xiao-Jin; Petersen, Denise; Pepper, Karen; Lutzko, Carolyn; Kohn, Donald B  (2006). Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors. Stem cells and development, 15 (1) , 109-17More Information

Sesti, Casilde; Hale, Sharon L; Lutzko, Carolyn; Kloner, Robert A  (2005). Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle mass. Journal of the American College of Cardiology, 46 (9) , 1662-9More Information

Tarantal, Alice F; McDonald, Ruth J; Jimenez, Daniel F; Lee, C Chang I; O'Shea, Cristin E; Leapley, Alyssa C; Won, Rosa H; Plopper, Charles G; Lutzko, Carolyn; Kohn, Donald B  (2005). Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery. Molecular therapy : the journal of the American Society of Gene Therapy, 12 (1) , 87-98More Information

Jodele, Sonata; Chantrain, Christophe F; Blavier, Laurence; Lutzko, Carolyn; Crooks, Gay M; Shimada, Hiroyuki; Coussens, Lisa M; Declerck, Yves A  (2005). The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer research, 65 (8) , 3200-8More Information

Haas, Dennis L; Lutzko, Carolyn; Logan, Aaron C; Cho, Gerald J; Skelton, Dianne; Jin Yu, Xiao; Pepper, Karen A; Kohn, Donald B  (2003). The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells. Journal of virology, 77 (17) , 9439-50

Lutzko, Carolyn; Senadheera, Dinithi; Skelton, Dianne; Petersen, Denise; Kohn, Donald B  (2003). Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes. Journal of virology, 77 (13) , 7341-51

Grove, Joanna E; Lutzko, Carolyn; Priller, Josef; Henegariu, Octavian; Theise, Neil D; Kohn, Donald B; Krause, Diane S  (2002). Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. American journal of respiratory cell and molecular biology, 27 (6) , 645-51More Information

Meertens, Lisa; Zhao, Yongjun; Rosic-Kablar, Suzana; Li, Liheng; Chan, Kin; Dobson, Howard; Gartley, Cathy; Lutzko, Carolyn; Hopwood, John; Kohn, Donald; Kruth, Stephen; Hough, Margaret R; Dubé, Ian D  (2002). In utero injection of alpha-L-iduronidase-carrying retrovirus in canine mucopolysaccharidosis type I: infection of multiple tissues and neonatal gene expression. Human gene therapy, 13 (15) , 1809-20More Information

Logan, Aaron C; Lutzko, Carolyn; Kohn, Donald B  (2002). Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Current opinion in biotechnology, 13 (5) , 429-36

Lutzko, Carolyn; Meertens, Lisa; Li, Liheng; Zhao, Yongjun; Abrams-Ogg, Anthony; Woods, J Paul; Kruth, Stephen; Hough, Margaret R; Dubé, Ian D  (2002). Human hematopoietic progenitors engraft in fetal canine recipients and expand with neonatal injection of fibroblasts expressing human hematopoietic cytokines. Experimental hematology, 30 (7) , 801-8

Lutzko, CAROLYN; Abrams-Ogg, ANTHONY C. G.; Li, LIHENG; Zhao, YONGJUN; Lau, KATHY; Kruth, STEPHEN; Dubé, IAN D.  (2000). BMT: Fractionation of Gene Modified Hematopoietic Autografts into Multiple Weekly Infusions Does Not Improve Engraftment in Unconditioned Canine Recipients. Hematology (Amsterdam, Netherlands), 4 (6) , 499-503

Rubinstein, Jeremy D; Lutzko, Carolyn; Leemhuis, Thomas; Zhu, Xiang; Pham, Giang; Ray, Lorraine; Thomas, Shawn; Dourson, Celeste; Wilhelm, Jamie; Lane, Adam; Cancelas, Jose A; Lipps, Dakota; Ferrell, Justin; Hanley, Patrick J; Keller, Michael D; Bollard, Catherine M; Wang, YunZu M; Davies, Stella M; Nelson, Adam S; Grimley, Michael S  (2022). Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood advances, 6 (9) , 2897-2907More Information

Rubinstein, Jeremy D; Jodele, Sonata; Heyenbruch, Daria; Wilhelm, Jamie; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Boghdadly, Zeinab El; Mims, Alice; Davies, Stella M; Grimley, Michael S; Nelson, Adam S  (2022). Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy, 28 (2) , 116.e1-116.e7More Information

Rubinstein, Jeremy D; Zhu, Xiang; Leemhuis, Thomas; Pham, Giang; Ray, Lorraine; Emberesh, Sana; Jodele, Sonata; Thomas, Shawn; Cancelas, Jose A; Bollard, Catherine M; Hanley, Patrick J; Keller, Michael D; Grimley, Olivia; Clark, Diana; Clark, Teri; Lindestam Arlehamn, Cecilia S; Sette, Alessandro; Davies, Stella M; Nelson, Adam S; Grimley, Michael S; Lutzko, Carolyn  (2021). Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood advances, 5 (17) , 3309-3321More Information

Laskin, Benjamin L; Denburg, Michelle R; Furth, Susan L; Moatz, Taylor; Altrich, Michelle; Kleiboeker, Steve; Lutzko, Carolyn; Zhu, Xiang; Blackard, Jason T; Jodele, Sonata; Lane, Adam; Wallace, Gregory; Dandoy, Christopher E; Lake, Kelly; Duell, Alexandra; Litts, Bridget; Seif, Alix E; Olson, Timothy; Bunin, Nancy; Davies, Stella M  (2020). The Natural History of BK Polyomavirus and the Host Immune Response After Stem Cell Transplantation. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71 (12) , 3044-3054More Information

Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A  (2020). VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. American journal of human genetics, 107 (6) , 1149-1156More Information

Nelson, Adam S; Heyenbruch, Daria; Rubinstein, Jeremy D; Sabulski, Anthony; Jodele, Sonata; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S  (2020). Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients. Blood advances, 4 (22) , 5745-5754More Information

Rubinstein, Jeremy D; Zhu, Xiang; Lutzko, Carolyn; Leemhuis, Tom; Cancelas, Jose A; Jodele, Sonata; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S; Nelson, Adam S  (2020). Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy. Blood advances, 4 (14) , 3252-3257More Information

Muench, David E; Olsson, Andre; Ferchen, Kyle; Pham, Giang; Serafin, Rachel A; Chutipongtanate, Somchai; Dwivedi, Pankaj; Song, Baobao; Hay, Stuart; Chetal, Kashish; Trump-Durbin, Lisa R; Mookerjee-Basu, Jayati; Zhang, Kejian; Yu, Jennifer C; Lutzko, Carolyn; Myers, Kasiani C; Nazor, Kristopher L; Greis, Kenneth D; Kappes, Dietmar J; Way, Sing Sing; Salomonis, Nathan; Grimes, H Leighton  (2020). Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature, 582 (7810) , 109-114More Information

Rubinstein, Jeremy D; Burns, Karen; Absalon, Michael; Lutzko, Carolyn; Leemhuis, Tom; Chandra, Sharat; Hanley, Patrick J; Keller, Michael D; Davies, Stella M; Nelson, Adam; Grimley, Michael  (2020). EBV-directed viral-specific T-lymphocyte therapy for the treatment of EBV-driven lymphoma in two patients with primary immunodeficiency and DNA repair defects. Pediatric blood & cancer, 67 (3) , e28126More Information

Khandelwal, Pooja; Chaturvedi, Vijaya; Owsley, Erika; Lane, Adam; Heyenbruch, Daria; Lutzko, Carolyn M; Leemhuis, Thomas; Grimley, Michael S; Nelson, Adam S; Davies, Stella M; Jordan, Michael B; Marsh, Rebecca A  (2020). CD38brightCD8+ T Cells Associated with the Development of Acute GVHD Are Activated, Proliferating, and Cytotoxic Trafficking Cells. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 26 (1) , 1-6More Information

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A  (2019). Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo. Stem cells translational medicine, 8 (6) , 557-567More Information

Daily, Kenneth; Ho Sui, Shannan J; Schriml, Lynn M; Dexheimer, Phillip J; Salomonis, Nathan; Schroll, Robin; Bush, Stacy; Keddache, Mehdi; Mayhew, Christopher; Lotia, Samad; Perumal, Thanneer M; Dang, Kristen; Pantano, Lorena; Pico, Alexander R; Grassman, Elke; Nordling, Diana; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Lutzko, Carolyn; Aronow, Bruce J; Omberg, Larsson  (2017). Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Scientific data, 4, 170030More Information

Salomonis, Nathan; Dexheimer, Phillip J; Omberg, Larsson; Schroll, Robin; Bush, Stacy; Huo, Jeffrey; Schriml, Lynn; Ho Sui, Shannan; Keddache, Mehdi; Mayhew, Christopher; Shanmukhappa, Shiva Kumar; Wells, James; Daily, Kenneth; Hubler, Shane; Wang, Yuliang; Zambidis, Elias; Margolin, Adam; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Aronow, Bruce J; Lutzko, Carolyn  (2016). Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium. Stem cell reports, 7 (1) , 110-25More Information

Nasimuzzaman, Md; Lynn, Danielle; Ernst, Rebecca; Beuerlein, Michele; Smith, Richard H; Shrestha, Archana; Cross, Scott; Link, Kevin; Lutzko, Carolyn; Nordling, Diana; Russell, David W; Larochelle, Andre; Malik, Punam; Van der Loo, Johannes C M  (2016). Production and purification of high-titer foamy virus vector for the treatment of leukocyte adhesion deficiency. Molecular therapy. Methods & clinical development, 3, 16004More Information

Nayak, Ramesh C; Trump, Lisa R; Aronow, Bruce J; Myers, Kasiani; Mehta, Parinda; Kalfa, Theodosia; Wellendorf, Ashley M; Valencia, C Alexander; Paddison, Patrick J; Horwitz, Marshall S; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A  (2015). Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. The Journal of clinical investigation, 125 (8) , 3103-16More Information

Suzuki, Takuji; Arumugam, Paritha; Sakagami, Takuro; Lachmann, Nico; Chalk, Claudia; Sallese, Anthony; Abe, Shuichi; Trapnell, Cole; Carey, Brenna; Moritz, Thomas; Malik, Punam; Lutzko, Carolyn; Wood, Robert E; Trapnell, Bruce C  (2014). Pulmonary macrophage transplantation therapy. Nature, 514 (7523) , 450-4More Information