Carolyn Lutzko

Field Service Professor-Affiliate

Childrens Hospital Bldg R

COM Pediatrics Experimental Hematology - 0054


Peer Reviewed Publications

Tsai, Steven C; Chang, David F; Hong, Chang-Mu; Xia, Ping; Senadheera, Dinithi; Trump, Lisa; Mishra, Suparna; Lutzko, Carolyn (2014. ) Induced overexpression of OCT4A in human embryonic stem cells increases cloning efficiency.American journal of physiology. Cell physiology, , 306 (12 ) ,C1108-18 More Information

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S (2014. ) Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.Blood, , 123 (4 ) ,562-9 More Information

Weiss, Daniel J; Bates, Jason H T; Gilbert, Thomas; Liles, W Conrad; Lutzko, Carolyn; Rajagopal, Jay; Prockop, Darwin (2013. ) Stem cells and cell therapies in lung biology and diseases: conference report.Annals of the American Thoracic Society, , 10 (5 ) ,S25-44 More Information

Chen, Leiling; Acciani, Thomas; Le Cras, Tim; Lutzko, Carolyn; Perl, Anne-Karina T (2012. ) Dynamic regulation of platelet-derived growth factor receptor ? expression in alveolar fibroblasts during realveolarization.American journal of respiratory cell and molecular biology, , 47 (4 ) ,517-27 More Information

Hasegawa, Kouichi; Yasuda, Shin-ya; Teo, Jia-Ling; Nguyen, Cu; McMillan, Michael; Hsieh, Chih-Lin; Suemori, Hirofumi; Nakatsuji, Norio; Yamamoto, Masashi; Miyabayashi, Tomoyuki; Lutzko, Carolyn; Pera, Martin F; Kahn, Michael (2012. ) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.Stem cells translational medicine, , 1 (1 ) ,18-28 More Information

Mishra, Suparna; Wang, Xingchao; Smiley, Nancy; Xia, Ping; Hong, Chang Mu; Senadheera, Dinithi; Bui, Kim Chi; Lutzko, Carolyn (2011. ) Genetic modification of airway progenitors after lentiviral gene delivery to the amniotic fluid of murine fetuses.American journal of respiratory cell and molecular biology, , 44 (4 ) ,562-70 More Information

Bui, Kim Chi T; Senadheera, Dinithi; Wang, Xingchao; Hendrickson, Benjamin; Friedlich, Philippe; Lutzko, Carolyn (2010. ) Recovery of multipotent progenitors from the peripheral blood of patients requiring extracorporeal membrane oxygenation support.American journal of respiratory and critical care medicine, , 181 (3 ) ,226-37 More Information

Jiang, Xiaohua; Gwye, Ynnez; McKeown, Sonja J; Bronner-Fraser, Marianne; Lutzko, Carolyn; Lawlor, Elizabeth R (2009. ) Isolation and characterization of neural crest stem cells derived from in vitro-differentiated human embryonic stem cells.Stem cells and development, , 18 (7 ) ,1059-70 More Information

Harb, Rula; Xie, Guanhua; Lutzko, Carolyn; Guo, Yumei; Wang, Xiangdong; Hill, Colin K; Kanel, Gary C; DeLeve, Laurie D (2009. ) Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury.Gastroenterology, , 137 (2 ) ,704-12 More Information

Chang, David F; Tsai, Steven C; Wang, Xing Chao; Xia, Ping; Senadheera, Dinithi; Lutzko, Carolyn (2009. ) Molecular characterization of the human NANOG protein.Stem cells (Dayton, Ohio), , 27 (4 ) ,812-21 More Information

Liebler, Janice M; Lutzko, Carolyn; Banfalvi, Agnes; Senadheera, Dinithi; Aghamohammadi, Neema; Crandall, Edward D; Borok, Zea (2008. ) Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury.American journal of physiology. Lung cellular and molecular physiology, , 295 (2 ) ,L285-92 More Information

Melchior, Kai; Weiss, Jonathan; Zaehres, Holm; Kim, Yong-mi; Lutzko, Carolyn; Roosta, Neda; Hescheler, Jürgen; Müschen, Markus (2008. ) The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells.Biological chemistry, , 389 (7 ) ,897-903 More Information

Rodriguez, Ryan T; Velkey, J Matthew; Lutzko, Carolyn; Seerke, Rina; Kohn, Donald B; O'Shea, K Sue; Firpo, Meri T (2007. ) Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types.Experimental biology and medicine (Maywood, N.J.), , 232 (10 ) ,1368-80 More Information

Hendrickson, Benjamin; Senadheera, Dinithi; Mishra, Suparna; Bui, Kim Chi T; Wang, Xingchao; Chan, Belinda; Petersen, Denise; Pepper, Karen; Lutzko, Carolyn (2007. ) Development of lentiviral vectors with regulated respiratory epithelial expression in vivo.American journal of respiratory cell and molecular biology, , 37 (4 ) ,414-23 More Information

Jang, Jung-Eun; Shaw, Kit; Yu, Xiao-Jin; Petersen, Denise; Pepper, Karen; Lutzko, Carolyn; Kohn, Donald B (2006. ) Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors.Stem cells and development, , 15 (1 ) ,109-17 More Information

Sesti, Casilde; Hale, Sharon L; Lutzko, Carolyn; Kloner, Robert A (2005. ) Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle mass.Journal of the American College of Cardiology, , 46 (9 ) ,1662-9 More Information

Tarantal, Alice F; McDonald, Ruth J; Jimenez, Daniel F; Lee, C Chang I; O'Shea, Cristin E; Leapley, Alyssa C; Won, Rosa H; Plopper, Charles G; Lutzko, Carolyn; Kohn, Donald B (2005. ) Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery.Molecular therapy : the journal of the American Society of Gene Therapy, , 12 (1 ) ,87-98 More Information

Jodele, Sonata; Chantrain, Christophe F; Blavier, Laurence; Lutzko, Carolyn; Crooks, Gay M; Shimada, Hiroyuki; Coussens, Lisa M; Declerck, Yves A (2005. ) The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent.Cancer research, , 65 (8 ) ,3200-8 More Information

Haas, Dennis L; Lutzko, Carolyn; Logan, Aaron C; Cho, Gerald J; Skelton, Dianne; Jin Yu, Xiao; Pepper, Karen A; Kohn, Donald B (2003. ) The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells. Journal of virology, , 77 (17 ) ,9439-50

Lutzko, Carolyn; Senadheera, Dinithi; Skelton, Dianne; Petersen, Denise; Kohn, Donald B (2003. ) Lentivirus vectors incorporating the immunoglobulin heavy chain enhancer and matrix attachment regions provide position-independent expression in B lymphocytes. Journal of virology, , 77 (13 ) ,7341-51

Grove, Joanna E; Lutzko, Carolyn; Priller, Josef; Henegariu, Octavian; Theise, Neil D; Kohn, Donald B; Krause, Diane S (2002. ) Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium.American journal of respiratory cell and molecular biology, , 27 (6 ) ,645-51 More Information

Meertens, Lisa; Zhao, Yongjun; Rosic-Kablar, Suzana; Li, Liheng; Chan, Kin; Dobson, Howard; Gartley, Cathy; Lutzko, Carolyn; Hopwood, John; Kohn, Donald; Kruth, Stephen; Hough, Margaret R; Dubé, Ian D (2002. ) In utero injection of alpha-L-iduronidase-carrying retrovirus in canine mucopolysaccharidosis type I: infection of multiple tissues and neonatal gene expression.Human gene therapy, , 13 (15 ) ,1809-20 More Information

Logan, Aaron C; Lutzko, Carolyn; Kohn, Donald B (2002. ) Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Current opinion in biotechnology, , 13 (5 ) ,429-36

Lutzko, Carolyn; Meertens, Lisa; Li, Liheng; Zhao, Yongjun; Abrams-Ogg, Anthony; Woods, J Paul; Kruth, Stephen; Hough, Margaret R; Dubé, Ian D (2002. ) Human hematopoietic progenitors engraft in fetal canine recipients and expand with neonatal injection of fibroblasts expressing human hematopoietic cytokines. Experimental hematology, , 30 (7 ) ,801-8

Lutzko, CAROLYN; Abrams-Ogg, ANTHONY C. G.; Li, LIHENG; Zhao, YONGJUN; Lau, KATHY; Kruth, STEPHEN; Dubé, IAN D. (2000. ) BMT: Fractionation of Gene Modified Hematopoietic Autografts into Multiple Weekly Infusions Does Not Improve Engraftment in Unconditioned Canine Recipients. Hematology (Amsterdam, Netherlands), , 4 (6 ) ,499-503

Rubinstein, Jeremy D; Lutzko, Carolyn; Leemhuis, Thomas; Zhu, Xiang; Pham, Giang; Ray, Lorraine; Thomas, Shawn; Dourson, Celeste; Wilhelm, Jamie; Lane, Adam; Cancelas, Jose A; Lipps, Dakota; Ferrell, Justin; Hanley, Patrick J; Keller, Michael D; Bollard, Catherine M; Wang, YunZu M; Davies, Stella M; Nelson, Adam S; Grimley, Michael S (2022. ) Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant.Blood advances, , 6 (9 ) ,2897-2907 More Information

Rubinstein, Jeremy D; Jodele, Sonata; Heyenbruch, Daria; Wilhelm, Jamie; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Boghdadly, Zeinab El; Mims, Alice; Davies, Stella M; Grimley, Michael S; Nelson, Adam S (2022. ) Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients.Transplantation and cellular therapy, , 28 (2 ) ,116.e1-116.e7 More Information

Rubinstein, Jeremy D; Zhu, Xiang; Leemhuis, Thomas; Pham, Giang; Ray, Lorraine; Emberesh, Sana; Jodele, Sonata; Thomas, Shawn; Cancelas, Jose A; Bollard, Catherine M; Hanley, Patrick J; Keller, Michael D; Grimley, Olivia; Clark, Diana; Clark, Teri; Lindestam Arlehamn, Cecilia S; Sette, Alessandro; Davies, Stella M; Nelson, Adam S; Grimley, Michael S; Lutzko, Carolyn (2021. ) Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.Blood advances, , 5 (17 ) ,3309-3321 More Information

Laskin, Benjamin L; Denburg, Michelle R; Furth, Susan L; Moatz, Taylor; Altrich, Michelle; Kleiboeker, Steve; Lutzko, Carolyn; Zhu, Xiang; Blackard, Jason T; Jodele, Sonata; Lane, Adam; Wallace, Gregory; Dandoy, Christopher E; Lake, Kelly; Duell, Alexandra; Litts, Bridget; Seif, Alix E; Olson, Timothy; Bunin, Nancy; Davies, Stella M (2020. ) The Natural History of BK Polyomavirus and the Host Immune Response After Stem Cell Transplantation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 71 (12 ) ,3044-3054 More Information

Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A (2020. ) VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects.American journal of human genetics, , 107 (6 ) ,1149-1156 More Information

Nelson, Adam S; Heyenbruch, Daria; Rubinstein, Jeremy D; Sabulski, Anthony; Jodele, Sonata; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S (2020. ) Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients.Blood advances, , 4 (22 ) ,5745-5754 More Information

Rubinstein, Jeremy D; Zhu, Xiang; Lutzko, Carolyn; Leemhuis, Tom; Cancelas, Jose A; Jodele, Sonata; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S; Nelson, Adam S (2020. ) Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy.Blood advances, , 4 (14 ) ,3252-3257 More Information

Muench, David E; Olsson, Andre; Ferchen, Kyle; Pham, Giang; Serafin, Rachel A; Chutipongtanate, Somchai; Dwivedi, Pankaj; Song, Baobao; Hay, Stuart; Chetal, Kashish; Trump-Durbin, Lisa R; Mookerjee-Basu, Jayati; Zhang, Kejian; Yu, Jennifer C; Lutzko, Carolyn; Myers, Kasiani C; Nazor, Kristopher L; Greis, Kenneth D; Kappes, Dietmar J; Way, Sing Sing; Salomonis, Nathan; Grimes, H Leighton (2020. ) Mouse models of neutropenia reveal progenitor-stage-specific defects.Nature, , 582 (7810 ) ,109-114 More Information

Rubinstein, Jeremy D; Burns, Karen; Absalon, Michael; Lutzko, Carolyn; Leemhuis, Tom; Chandra, Sharat; Hanley, Patrick J; Keller, Michael D; Davies, Stella M; Nelson, Adam; Grimley, Michael (2020. ) EBV-directed viral-specific T-lymphocyte therapy for the treatment of EBV-driven lymphoma in two patients with primary immunodeficiency and DNA repair defects.Pediatric blood & cancer, , 67 (3 ) ,e28126 More Information

Khandelwal, Pooja; Chaturvedi, Vijaya; Owsley, Erika; Lane, Adam; Heyenbruch, Daria; Lutzko, Carolyn M; Leemhuis, Thomas; Grimley, Michael S; Nelson, Adam S; Davies, Stella M; Jordan, Michael B; Marsh, Rebecca A (2020. ) CD38brightCD8+ T Cells Associated with the Development of Acute GVHD Are Activated, Proliferating, and Cytotoxic Trafficking Cells.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , 26 (1 ) ,1-6 More Information

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A (2019. ) Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.Stem cells translational medicine, , 8 (6 ) ,557-567 More Information

Daily, Kenneth; Ho Sui, Shannan J; Schriml, Lynn M; Dexheimer, Phillip J; Salomonis, Nathan; Schroll, Robin; Bush, Stacy; Keddache, Mehdi; Mayhew, Christopher; Lotia, Samad; Perumal, Thanneer M; Dang, Kristen; Pantano, Lorena; Pico, Alexander R; Grassman, Elke; Nordling, Diana; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Lutzko, Carolyn; Aronow, Bruce J; Omberg, Larsson (2017. ) Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives.Scientific data, , 4 ,170030 More Information

Salomonis, Nathan; Dexheimer, Phillip J; Omberg, Larsson; Schroll, Robin; Bush, Stacy; Huo, Jeffrey; Schriml, Lynn; Ho Sui, Shannan; Keddache, Mehdi; Mayhew, Christopher; Shanmukhappa, Shiva Kumar; Wells, James; Daily, Kenneth; Hubler, Shane; Wang, Yuliang; Zambidis, Elias; Margolin, Adam; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Aronow, Bruce J; Lutzko, Carolyn (2016. ) Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium.Stem cell reports, , 7 (1 ) ,110-25 More Information

Nasimuzzaman, Md; Lynn, Danielle; Ernst, Rebecca; Beuerlein, Michele; Smith, Richard H; Shrestha, Archana; Cross, Scott; Link, Kevin; Lutzko, Carolyn; Nordling, Diana; Russell, David W; Larochelle, Andre; Malik, Punam; Van der Loo, Johannes C M (2016. ) Production and purification of high-titer foamy virus vector for the treatment of leukocyte adhesion deficiency.Molecular therapy. Methods & clinical development, , 3 ,16004 More Information

Nayak, Ramesh C; Trump, Lisa R; Aronow, Bruce J; Myers, Kasiani; Mehta, Parinda; Kalfa, Theodosia; Wellendorf, Ashley M; Valencia, C Alexander; Paddison, Patrick J; Horwitz, Marshall S; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A (2015. ) Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.The Journal of clinical investigation, , 125 (8 ) ,3103-16 More Information

Suzuki, Takuji; Arumugam, Paritha; Sakagami, Takuro; Lachmann, Nico; Chalk, Claudia; Sallese, Anthony; Abe, Shuichi; Trapnell, Cole; Carey, Brenna; Moritz, Thomas; Malik, Punam; Lutzko, Carolyn; Wood, Robert E; Trapnell, Bruce C (2014. ) Pulmonary macrophage transplantation therapy.Nature, , 514 (7523 ) ,450-4 More Information