Rajat Madan

Rajat Madan , MD, PhD

Associate Professor of Clinical

Medical Sciences Building
Room 6105C
231 Albert Sabin Way
Cincinnati, Ohio 45267
Phone 513-558-4704
Fax 513-558-2089
Email rajat.madan@uc.edu

Education

Bachelor of Medicine, Bachelor or Surgery (M.B.B.S): JLN Medical College 2000

Doctoral Degree: University of Cincinnati 2009 (Molecular and Developmental Biology and Molecular Immunology)

Residency: The Christ Hospital 2011 (Internal Medicine)

Fellowship: University of Virginia 2014 (Infectious Diseases)

Certifications

American Board of Internal Medicine (Infectious Disease) (Certification Date: 10-28-2014 )

American Board of Internal Medicine (Certification Date: 08-12-2011 )

Clinical Interests

Infectious Disease

Specialities

Infectious Disease

Internal Medicine

Research and Practice Interests

The overall research goal of our laboratory is to better understand the cellular and molecular mechanisms by which nutrition, metabolism, and immune responses to infections are fundamentally linked. Leptin is an adipose tissue-secreted cytokine that sits at the intersection of metabolism and immunity. Interestingly obesity is a state of high serum leptin levels, thus leptin by virtue of its multiple physiologic effects is likely to play an important role in directing inflammation in obese patients as well, who represent a rapidly expanding population demographic worldwide. Clostridium difficile is the #1 cause of healthcare-associated diarrhea in the U.S.
In our lab, we are investigating the role of leptin receptor polymorphisms and obesity (as measured by Body Mass Index) in affecting disease susceptibility, severity and disease outcomes in patients with C. difficile infection. In parallel, we are using various leptin transgenic mice and diet-induced obese mice to interrogate the mechanism(s) by which leptin signaling impacts the immune response during C. difficile infections. Our studies (using both human clinical samples and mouse models) have the potential to augment the current treatment paradigm for C. difficile with therapies directed at the host immune response. 

Research Support

Grant: #K08 AI108801 Investigators:Madan, Rajat 01-01-2015 -07-31-2019 National Institute of Allergy and Infectious Diseases Role of leptin in mucosal protection during Clostridium difficile infection Role:PI $176,057.00 Active Level:Federal

Grant: #Research Collaboration Agreement Investigators:Madan, Rajat 06-01-2018 -05-31-2019 Cincinnati Children's Hospital Medical Center Impact of obesity-associated microbiome and bile acid metabolites in regulating Clostridium difficile lifecycle Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #R01AI158451 Investigators:Madan, Rajat; Weiss, Alison 09-17-2021 -08-31-2026 National Institute of Allergy and Infectious Diseases Regulation of C. difficile colitis by host genetic and immune factors Role:PI 411085.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Jose, Shinsmon; Madan, Rajat (2016. ) Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections.Anaerobe, , More Information

Madan, Rajat; Demircik, Filiz; Surianarayanan, Sangeetha; Allen, Jessica L; Divanovic, Senad; Trompette, Aurelien; Yogev, Nir; Gu, Yuanyuan; Khodoun, Marat; Hildeman, David; Boespflug, Nicholas; Fogolin, Mariela B; Gröbe, Lothar; Greweling, Marina; Finkelman, Fred D; Cardin, Rhonda; Mohrs, Markus; Müller, Werner; Waisman, Ari; Roers, Axel; Karp, Christopher L (2009. ) Nonredundant roles for B cell-derived IL-10 in immune counter-regulation.Journal of immunology (Baltimore, Md. : 1950), , 183 (4 ) ,2312-20 More Information

Trompette, Aurelien; Divanovic, Senad; Visintin, Alberto; Blanchard, Carine; Hegde, Rashmi S; Madan, Rajat; Thorne, Peter S; Wills-Karp, Marsha; Gioannini, Theresa L; Weiss, Jerry P; Karp, Christopher L (2009. ) Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.Nature, , 457 (7229 ) ,585-8 More Information

Dragin, Nadine; Shi, Zhanquan; Madan, Rajat; Karp, Christopher L; Sartor, Maureen A; Chen, Chi; Gonzalez, Frank J; Nebert, Daniel W (2008. ) Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.Molecular pharmacology, , 73 (6 ) ,1844-56 More Information

Divanovic, Senad; Trompette, Aurelien; Petiniot, Lisa K; Allen, Jessica L; Flick, Leah M; Belkaid, Yasmine; Madan, Rajat; Haky, Jennifer J; Karp, Christopher L (2007. ) Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105.Journal of leukocyte biology, , 82 (2 ) ,265-71 More Information

Tripathi, Pulak; Madan, Rajat; Chougnet, Claire; Divanovic, Senad; Ma, Xiaojing; Wahl, Larry M; Gajewski, Thomas; Karp, Christopher L; Hildeman, David A (2006. ) An adenoviral vector for probing promoter activity in primary immune cells.Journal of immunological methods, , 311 (1-2 ) ,19-30 More Information

Divanovic, Senad; Trompette, Aurelien; Atabani, Sowsan F; Madan, Rajat; Golenbock, Douglas T; Visintin, Alberto; Finberg, Robert W; Tarakhovsky, Alexander; Vogel, Stefanie N; Belkaid, Yasmine; Kurt-Jones, Evelyn A; Karp, Christopher L (2005. ) Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.Nature immunology, , 6 (6 ) ,571-8 More Information

Divanovic, Senad; Trompette, Aurelien; Atabani, Sowsan F; Madan, Rajat; Golenbock, Douglas T; Visintin, Alberto; Finberg, Robert W; Tarakhovsky, Alexander; Vogel, Stefanie N; Belkaid, Yasmine; Kurt-Jones, Evelyn A; Karp, Christopher L (2005. ) Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.Journal of endotoxin research, , 11 (6 ) ,363-8 More Information

Madan, Rajat; Petri, William A (2015. ) Role of obesity and adipose tissue-derived cytokine leptin during Clostridium difficile infection.Anaerobe, , 34 ,182-6 More Information

Sun, Jie; Madan, Rajat; Karp, Christopher L; Braciale, Thomas J (2009. ) Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.Nature medicine, , 15 (3 ) ,277-84 More Information

Pot, Caroline; Jin, Hulin; Awasthi, Amit; Liu, Sue Min; Lai, Chen-Yen; Madan, Rajat; Sharpe, Arlene H; Karp, Christopher L; Miaw, Shi-Chuen; Ho, I-Cheng; Kuchroo, Vijay K (2009. ) Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.Journal of immunology (Baltimore, Md. : 1950), , 183 (2 ) ,797-801 More Information

Murai, Masako; Turovskaya, Olga; Kim, Gisen; Madan, Rajat; Karp, Christopher L; Cheroutre, Hilde; Kronenberg, Mitchell (2009. ) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.Nature immunology, , 10 (11 ) ,1178-84 More Information

Denning, Timothy L; Norris, Brian A; Medina-Contreras, Oscar; Manicassamy, Santhakumar; Geem, Duke; Madan, Rajat; Karp, Christopher L; Pulendran, Bali (2011. ) Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.Journal of immunology (Baltimore, Md. : 1950), , 187 (2 ) ,733-47 More Information

Perona-Wright, Georgia; Mohrs, Katja; Szaba, Frank M; Kummer, Lawrence W; Madan, Rajat; Karp, Christopher L; Johnson, Lawrence L; Smiley, Stephen T; Mohrs, Markus (2009. ) Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells.Cell host & microbe, , 6 (6 ) ,503-12 More Information

Naylor, Caitlin; Burgess, Stacey; Madan, Rajat; Buonomo, Erica; Razzaq, Khadija; Ralston, Katherine; Petri, William A (2014. ) Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection.mBio, , 5 (6 ) , More Information

Madan, Rajat; Guo, Xiaoti; Naylor, Caitlin; Buonomo, Erica L; Mackay, Donald; Noor, Zannatun; Concannon, Patrick; Scully, Kenneth W; Pramoonjago, Patcharin; Kolling, Glynis L; Warren, Cirle A; Duggal, Priya; Petri, William A (2014. ) Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis.Infection and immunity, , 82 (1 ) ,341-9 More Information

Buonomo, Erica L; Madan, Rajat; Pramoonjago, Patcharin; Li, Li; Okusa, Mark D; Petri, William A (2013. ) Role of interleukin 23 signaling in Clostridium difficile colitis.The Journal of infectious diseases, , 208 (6 ) ,917-20 More Information

Jarrell, Andrew; Kawsky, Jaclyn; Johnson, Tara; Voss, Sasha; Madan, Rajat; Weitkamp, Tina; Wigle, Patricia (2013. ) An interdisciplinary approach to determine schistosomiasis prevalence and administer praziquantel to school-age children in Tanzania.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, , 70 (21 ) ,1880-2 More Information

Madan, Rajat; Jr, William A Petri (2012. ) Immune responses to Clostridium difficile infection.Trends in molecular medicine, , 18 (11 ) ,658-66 More Information

Machado, Fabiana S; Esper, Lísia; Dias, Alexandra; Madan, Rajat; Gu, YuanYuan; Hildeman, David; Serhan, Charles N; Karp, Christopher L; Aliberti, Júlio (2008. ) Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.The Journal of experimental medicine, , 205 (5 ) ,1077-86 More Information

Vargas, Edwin; Apewokin, Senu; Madan, Rajat (2017. ) Role of the leukocyte response in normal and immunocompromised host after Clostridium difficile infection.Anaerobe, , 45 ,101-105 More Information

Jose, Shinsmon; Mukherjee, Anindita; Abhyankar, Mayuresh M; Leng, Lin; Bucala, Richard; Sharma, Divya; Madan, Rajat (2018. ) Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection.Anaerobe, , More Information

Alarcon, Pablo C; Damen, Michelle S M A; Madan, Rajat; Deepe, George S; Spearman, Paul; Way, Sing Sing; Divanovic, Senad (2021. ) Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution.Mucosal immunology, , More Information

Jose, Shinsmon; Mukherjee, Anindita; Horrigan, Olivia; Setchell, Kenneth D R; Zhang, Wujuan; Moreno-Fernandez, Maria E; Andersen, Heidi; Sharma, Divya; Haslam, David B; Divanovic, Senad; Madan, Rajat (2021. ) Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice.Mucosal immunology, , 14 (2 ) ,500-510 More Information

Horrigan, Olivia; Jose, Shinsmon; Mukherjee, Anindita; Sharma, Divya; Huber, Alexander; Madan, Rajat (2021. ) Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1? Dependent Manner.Frontiers in cellular and infection microbiology, , 11 ,619192 More Information

Contact Information

Academic - Medical Sciences Building
Room 6105C
Cincinnati  Ohio, 45267
Phone: 513-558-4704
Fax: 513-558-2089
rajat.madan@uc.edu