Dennis W. McGraw, MD

Bachelor's Degree : Millsaps College 1982 (Biology, Cum Laude)

Medical Degree: University of Mississippi Medical Center 1986

Internship : University of Arkansas for Medical Sciences 1987 (Internal Medicine )

Residency: University of Arkansas for Medical Sciences 1989 (Internal Medicine )

Fellowship: University of Arkansas for Medical Sciences 1993 (Pulmonary and Critical Care Medicine )

American Board of Internal Medicine (Certification Date: 09-13-1989 )

American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 11-04-1992 ) - (Recertification Date: to 05-26-2024 )

Critical Care Medicine

Pulmonary Disease

Internal Medicine

Critical Care Medicine

Internal Medicine

G-Protein Receptor Signaling (Asthma, G-Protein Coupled Receptors, Adrenergic Receptors, Airway Smooth Muscle).

1993 -1996 Instructor, Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, AR

1996 -1998 Instructor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1998 -2005 Assistant Professor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2005 -To Present Associate Professor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1991 UAMS Research Endowment Fund

10-1993 -10-1994 VA Associate Investigator Career Development Award B2-Adrenergic Receptor Gene Expression in the Lung Role:PI

06-2005 -05-2007 University of Cincinnati Dean's Discovery Fund Establishment of a Research Bronchoscopy Core Role:PI

05-2007 -03-2008 University of Cincinnati Center for Environmental Genetics Pilot Project Program Epigenetic Dysregulation of Airway Epithelial Cell Gene Expression in the Pathogenesis of Smoking-induced COPD Role:PI

Grant: #R01-HL-072068 Investigators:McGraw, Dennis 09-01-2003 -08-31-2007 National Heart, Lung and Blood Institute Signaling and Crosstalk by Airway Prostanoid Receptors Role:PI Closed 001102-001 Level:Federal

Grant: #5-K08-HL-03986-05-A0-S0-E0 Investigators:McGraw, Dennis 05-04-1999 -04-30-2004 National Heart, Lung and Blood Institute Mechanisms of Lung Beta2AR Function in Transgenic Mice Role:PI Closed 004561-001 Level:Federal

Grant: #R01 HL092121 Investigators:McGraw, Dennis 09-01-2009 -08-31-2013 National Heart, Lung and Blood Institute The Role of Ga2 Signaling in Hypertension Role:PI Active 006425-001 Level:Federal

Grant: #AHA 0765363B Investigators:McGraw, Dennis; Petrovic, Snezana; Terbeest, Martin 07-01-2007 -06-30-2009 American Heart Association - Great Rivers Affiliate Proton-Sensing Receptor in the Kidney Role:Collaborator $60,500.00 Closed Level:Private Non-Profit

Grant: #R01 ES009110 Investigators:Abdelmalek, Zalfa; Boissy, Raymond; Kadekaro, Ana Luisa; McGraw, Dennis 04-01-2008 -03-31-2013 National Institute of Environmental Health Sciences Signaling Pathways for UV-Induced Melanogenic Response Role:Collaborator $1,304,738.00 Active Level:Federal

Peer Reviewed Publications

Reszka, Krzysztof J; Sallans, Larry; Macha, Stephen; Brown, Kari; McGraw, Dennis W; Kovacic, Melinda Butsch; Britigan, Bradley E  (2011). Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity. The Journal of pharmacology and experimental therapeutics, 336 (2) , 440-9More Information

Sun, Xuming; Yang, Li V; Tiegs, Brian C; Arend, Lois J; McGraw, Dennis W; Penn, Raymond B; Petrovic, Snezana  (2010). Deletion of the pH sensor GPR4 decreases renal acid excretion. Journal of the American Society of Nephrology : JASN, 21 (10) , 1745-55More Information

Reszka, Krzysztof J; McGraw, Dennis W; Britigan, Bradley E  (2009). Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues. Chemical research in toxicology, 22 (6) , 1137-50More Information

Borchers, Michael T; Wesselkamper, Scott C; Curull, Victor; Ramirez-Sarmiento, Alba; Sánchez-Font, Albert; Garcia-Aymerich, Judith; Coronell, Carlos; Lloreta, Josep; Agusti, Alvar G; Gea, Joaquim; Howington, John A; Reed, Michael F; Starnes, Sandra L; Harris, Nathaniel L; Vitucci, Mark; Eppert, Bryan L; Motz, Gregory T; Fogel, Kevin; McGraw, Dennis W; Tichelaar, Jay W; Orozco-Levi, Mauricio  (2009). Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. The Journal of clinical investigation, 119 (3) , 636-49More Information

McGraw, Dennis W; Elwing, Jean M; Fogel, Kevin M; Wang, Wayne C H; Glinka, Clare B; Mihlbachler, Kathryn A; Rothenberg, Marc E; Liggett, Stephen B  (2007). Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of clinical investigation, 117 (5) , 1391-8More Information

McGraw, Dennis W; Fogel, Kevin M; Kong, Sue; Litonjua, Augusto A; Kranias, Evangelia G; Aronow, Bruce J; Liggett, Stephen B  (2006). Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological genomics, 27 (2) , 171-7More Information

McGraw, Dennis W; Mihlbachler, Kathryn A; Schwarb, Mary Rose; Rahman, Fahema F; Small, Kersten M; Almoosa, Khalid F; Liggett, Stephen B  (2006). Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of clinical investigation, 116 (5) , 1400-9More Information

Pathak, Anand; del Monte, Federica; Zhao, Wen; Schultz, Jo-El; Lorenz, John N; Bodi, Ilona; Weiser, Doug; Hahn, Harvey; Carr, Andrew N; Syed, Faisal; Mavila, Nirmala; Jha, Leena; Qian, Jiang; Marreez, Yehia; Chen, Guoli; McGraw, Dennis W; Heist, E Kevin; Guerrero, J Luis; DePaoli-Roach, Anna A; Hajjar, Roger J; Kranias, Evangelia G  (2005). Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation research, 96 (7) , 756-66More Information

McGraw, Dennis W; Liggett, Stephen B  (2005). Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society, 2 (4) , 292-6; discussion 31More Information

McGraw, Dennis W; Almoosa, Khalid F; Paul, Richard J; Kobilka, Brian K; Liggett, Stephen B  (2003). Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of clinical investigation, 112 (4) , 619-26More Information

Small, Kersten M; McGraw, Dennis W; Liggett, Stephen B  (2003). Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual review of pharmacology and toxicology, 43, 381-411More Information

McGraw, Dennis W  (2002). Transgenic techniques to delineate cell-specific effects of beta2-adrenergic receptors in the lung. The Journal of allergy and clinical immunology, 110 (6 Suppl) , S236-41

Sartori, C; Fang, X; McGraw, D W; Koch, P; Snider, M E; Folkesson, H G; Matthay, M A  (2002). Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. Journal of applied physiology (Bethesda, Md. : 1985), 93 (5) , 1875-80More Information

Krane, C M; Fortner, C N; Hand, A R; McGraw, D W; Lorenz, J N; Wert, S E; Towne, J E; Paul, R J; Whitsett, J A; Menon, A G  (2001). Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proceedings of the National Academy of Sciences of the United States of America, 98 (24) , 14114-9More Information

McGraw, D W; Fukuda, N; James, P F; Forbes, S L; Woo, A L; Lingrel, J B; Witte, D P; Matthay, M A; Liggett, S B  (2001). Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology, 281 (4) , L895-903

Drysdale, C M; McGraw, D W; Stack, C B; Stephens, J C; Judson, R S; Nandabalan, K; Arnold, K; Ruano, G; Liggett, S B  (2000). Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America, 97 (19) , 10483-8

Cao, W; McGraw, D W; Lee, T T; Dicker-Brown, A; Hiller, F C; Cornett, L E; Jones, S M  (2000). Expression of functional beta 2-adrenergic receptors in a rat airway epithelial cell line (SPOC1) and cell density-dependent induction by glucocorticoids. Experimental lung research, 26 (6) , 421-35

McGraw, D W; Forbes, S L; Mak, J C; Witte, D P; Carrigan, P E; Leikauf, G D; Liggett, S B  (2000). Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American journal of physiology. Lung cellular and molecular physiology, 279 (2) , L379-89

McGraw, D W; Liggett, S B  (1999). Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 4, 43-5

McGraw, D W; Forbes, S L; Kramer, L A; Witte, D P; Fortner, C N; Paul, R J; Liggett, S B  (1999). Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry, 274 (45) , 32241-7

McGraw, D W; Forbes, S L; Kramer, L A; Liggett, S B  (1998). Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. The Journal of clinical investigation, 102 (11) , 1927-32More Information

Cornett, L E; Hiller, F C; Jacobi, S E; Cao, W; McGraw, D W  (1998). Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Molecular pharmacology, 54 (6) , 1016-23

Baeyens, D A; McGraw, D W; Jacobi, S E; Cornett, L E  (1998). Transcription of the beta2-adrenergic receptor gene in rat liver is regulated during early postnatal development by an upstream repressor element. Journal of cellular physiology, 175 (3) , 333-40More Information

McGraw, D W; Donnelly, E T; Eason, M G; Green, S A; Liggett, S B  (1998). Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular signalling, 10 (3) , 197-204

McGraw, D W; Liggett, S B  (1997). Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of biological chemistry, 272 (11) , 7338-44

McGraw, D W; Jacobi, S E; Hiller, F C; Cornett, L E  (1996). Structural and functional analysis of the 5'-flanking region of the rat beta 2-adrenergic receptor gene. Biochimica et biophysica acta, 1305 (3) , 135-8

McGraw, D W; Chai, S E; Hiller, F C; Cornett, L ERegulation of the beta 2-adrenergic receptor and its mRNA in the rat lung by dexamethasone. Experimental lung research, 21 (4) , 535-46

Gupta, Nishant; Kralovic, Stephen M; McGraw, Dennis  (2014). Lemierre syndrome: not so forgotten!. American journal of critical care : an official publication, American Association of Critical-Care Nurses, 23 (2) , 176-9More Information

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A  (2012). Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 (9) , 2255-62More Information

Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T  (2020). MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI insight, 5 (4) More Information

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X  (2015). Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 (313) , 313ra181More Information

1992 Allen & Hanbury's Respiratory Institute Pulmonary Fellowship Award "Regulation of B2-Adrenergic Receptor Gene Expression in the Lung"

1993 Red Sash Teaching Award by graduating seniors University of Arkansas for Medical Sciences

1997 -1999 Fellow NIH Program of Excellence in Molecular Biology, University of Cincinnati

lung, respiratory, pulmonology

Academic - Medical Sciences Building
University of Cincinnati
Cincinnati  Ohio, 45267-0564
Phone: 513-558-4831
Fax: 513-558-4858
dennis.mcgraw@uc.edu