Dennis McGraw

Dennis W McGraw

Director, Veterans Hospital Pulmonary

Cardiovascular Rsrch Cntr

4925

COM IM PUL McGraw Lab - 0564

Medical Sciences Building
University of Cincinnati
Cincinnati, Ohio 45267-0564

Education

Bachelor's Degree , Millsaps College 1982 (Biology, Cum Laude)

Medical Degree, University of Mississippi Medical Center 1986

Internship , University of Arkansas for Medical Sciences 1987 (Internal Medicine )

Residency, University of Arkansas for Medical Sciences 1989 (Internal Medicine )

Fellowship, University of Arkansas for Medical Sciences 1993 (Pulmonary and Critical Care Medicine )

Positions and Work Experience

1993 -1996 Instructor, Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, AR

1996 -1998 Instructor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

1998 -2005 Assistant Professor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2005 -To Present Associate Professor, Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

Research and Practice Interests

G-Protein Receptor Signaling (Asthma, G-Protein Coupled Receptors, Adrenergic Receptors, Airway Smooth Muscle).

Clinical Focus

Critical Care Medicine

Pulmonary Disease

Specialities

Critical Care Medicine

Internal Medicine

Certifications

American Board of Internal Medicine

09/13/1989

American Board of Internal Medicine (Pulmonary Disease)

11/04/1992

Research Support

1991 UAMS Research Endowment Fund

10-1993 -10-1994 VA Associate Investigator Career Development Award B2-Adrenergic Receptor Gene Expression in the Lung Role:PI

06-2005 -05-2007 University of Cincinnati Dean's Discovery Fund Establishment of a Research Bronchoscopy Core Role:PI

05-2007 -03-2008 University of Cincinnati Center for Environmental Genetics Pilot Project Program Epigenetic Dysregulation of Airway Epithelial Cell Gene Expression in the Pathogenesis of Smoking-induced COPD Role:PI

Grant: #R01-HL-072068 Investigators:McGraw, Dennis 09-01-2003 -08-31-2007 National Heart, Lung and Blood Institute Signaling and Crosstalk by Airway Prostanoid Receptors Role:PI Closed 001102-001 Level:Federal

Grant: #5-K08-HL-03986-05-A0-S0-E0 Investigators:McGraw, Dennis 05-04-1999 -04-30-2004 National Heart, Lung and Blood Institute Mechanisms of Lung Beta2AR Function in Transgenic Mice Role:PI Closed 004561-001 Level:Federal

Grant: #R01 HL092121 Investigators:McGraw, Dennis 09-01-2009 -08-31-2013 National Heart, Lung and Blood Institute The Role of Ga2 Signaling in Hypertension Role:PI Active 006425-001 Level:Federal

Grant: #AHA 0765363B Investigators:McGraw, Dennis; Petrovic, Snezana; Terbeest, Martin 07-01-2007 -06-30-2009 American Heart Association - Great Rivers Affiliate Proton-Sensing Receptor in the Kidney Role:Collaborator $60,500.00 Closed Level:Private Non-Profit

Grant: #R01 ES009110 Investigators:Abdelmalek, Zalfa; Boissy, Raymond; Kadekaro, Ana Luisa; McGraw, Dennis 04-01-2008 -03-31-2013 National Institute of Environmental Health Sciences Signaling Pathways for UV-Induced Melanogenic Response Role:Collaborator $1,304,738.00 Active Level:Federal

Publications

Peer Reviewed Publications

Reszka, Krzysztof J; Sallans, Larry; Macha, Stephen; Brown, Kari; McGraw, Dennis W; Kovacic, Melinda Butsch; Britigan, Bradley E (2011. ) Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity.The Journal of pharmacology and experimental therapeutics, , 336 (2 ) ,440-9

Sun, Xuming; Yang, Li V; Tiegs, Brian C; Arend, Lois J; McGraw, Dennis W; Penn, Raymond B; Petrovic, Snezana (2010. ) Deletion of the pH sensor GPR4 decreases renal acid excretion.Journal of the American Society of Nephrology : JASN, , 21 (10 ) ,1745-55

Reszka, Krzysztof J; McGraw, Dennis W; Britigan, Bradley E (2009. ) Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues.Chemical research in toxicology, , 22 (6 ) ,1137-50

Borchers, Michael T; Wesselkamper, Scott C; Curull, Victor; Ramirez-Sarmiento, Alba; Sánchez-Font, Albert; Garcia-Aymerich, Judith; Coronell, Carlos; Lloreta, Josep; Agusti, Alvar G; Gea, Joaquim; Howington, John A; Reed, Michael F; Starnes, Sandra L; Harris, Nathaniel L; Vitucci, Mark; Eppert, Bryan L; Motz, Gregory T; Fogel, Kevin; McGraw, Dennis W; Tichelaar, Jay W; Orozco-Levi, Mauricio (2009. ) Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.The Journal of clinical investigation, , 119 (3 ) ,636-49

McGraw, Dennis W; Elwing, Jean M; Fogel, Kevin M; Wang, Wayne C H; Glinka, Clare B; Mihlbachler, Kathryn A; Rothenberg, Marc E; Liggett, Stephen B (2007. ) Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.The Journal of clinical investigation, , 117 (5 ) ,1391-8

McGraw, Dennis W; Fogel, Kevin M; Kong, Sue; Litonjua, Augusto A; Kranias, Evangelia G; Aronow, Bruce J; Liggett, Stephen B (2006. ) Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility.Physiological genomics, , 27 (2 ) ,171-7

McGraw, Dennis W; Mihlbachler, Kathryn A; Schwarb, Mary Rose; Rahman, Fahema F; Small, Kersten M; Almoosa, Khalid F; Liggett, Stephen B (2006. ) Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.The Journal of clinical investigation, , 116 (5 ) ,1400-9

Pathak, Anand; del Monte, Federica; Zhao, Wen; Schultz, Jo-El; Lorenz, John N; Bodi, Ilona; Weiser, Doug; Hahn, Harvey; Carr, Andrew N; Syed, Faisal; Mavila, Nirmala; Jha, Leena; Qian, Jiang; Marreez, Yehia; Chen, Guoli; McGraw, Dennis W; Heist, E Kevin; Guerrero, J Luis; DePaoli-Roach, Anna A; Hajjar, Roger J; Kranias, Evangelia G (2005. ) Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.Circulation research, , 96 (7 ) ,756-66

McGraw, Dennis W; Liggett, Stephen B (2005. ) Molecular mechanisms of beta2-adrenergic receptor function and regulation.Proceedings of the American Thoracic Society, , 2 (4 ) ,292-6; discussion 31

McGraw, Dennis W; Almoosa, Khalid F; Paul, Richard J; Kobilka, Brian K; Liggett, Stephen B (2003. ) Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.The Journal of clinical investigation, , 112 (4 ) ,619-26

Small, Kersten M; McGraw, Dennis W; Liggett, Stephen B (2003. ) Pharmacology and physiology of human adrenergic receptor polymorphisms.Annual review of pharmacology and toxicology, , 43 ,381-411

McGraw, Dennis W (2002. ) Transgenic techniques to delineate cell-specific effects of beta2-adrenergic receptors in the lung. The Journal of allergy and clinical immunology, , 110 (6 Suppl ) ,S236-41

Sartori, C; Fang, X; McGraw, D W; Koch, P; Snider, M E; Folkesson, H G; Matthay, M A (2002. ) Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice.Journal of applied physiology (Bethesda, Md. : 1985), , 93 (5 ) ,1875-80

Krane, C M; Fortner, C N; Hand, A R; McGraw, D W; Lorenz, J N; Wert, S E; Towne, J E; Paul, R J; Whitsett, J A; Menon, A G (2001. ) Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.Proceedings of the National Academy of Sciences of the United States of America, , 98 (24 ) ,14114-9

McGraw, D W; Fukuda, N; James, P F; Forbes, S L; Woo, A L; Lingrel, J B; Witte, D P; Matthay, M A; Liggett, S B (2001. ) Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology, , 281 (4 ) ,L895-903

Drysdale, C M; McGraw, D W; Stack, C B; Stephens, J C; Judson, R S; Nandabalan, K; Arnold, K; Ruano, G; Liggett, S B (2000. ) Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America, , 97 (19 ) ,10483-8

Cao, W; McGraw, D W; Lee, T T; Dicker-Brown, A; Hiller, F C; Cornett, L E; Jones, S M (2000. ) Expression of functional beta 2-adrenergic receptors in a rat airway epithelial cell line (SPOC1) and cell density-dependent induction by glucocorticoids. Experimental lung research, , 26 (6 ) ,421-35

McGraw, D W; Forbes, S L; Mak, J C; Witte, D P; Carrigan, P E; Leikauf, G D; Liggett, S B (2000. ) Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American journal of physiology. Lung cellular and molecular physiology, , 279 (2 ) ,L379-89

McGraw, D W; Liggett, S B (1999. ) Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , 29 Suppl 4 ,43-5

McGraw, D W; Forbes, S L; Kramer, L A; Witte, D P; Fortner, C N; Paul, R J; Liggett, S B (1999. ) Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry, , 274 (45 ) ,32241-7

McGraw, D W; Forbes, S L; Kramer, L A; Liggett, S B (1998. ) Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.The Journal of clinical investigation, , 102 (11 ) ,1927-32

Cornett, L E; Hiller, F C; Jacobi, S E; Cao, W; McGraw, D W (1998. ) Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Molecular pharmacology, , 54 (6 ) ,1016-23

Baeyens, D A; McGraw, D W; Jacobi, S E; Cornett, L E (1998. ) Transcription of the beta2-adrenergic receptor gene in rat liver is regulated during early postnatal development by an upstream repressor element.Journal of cellular physiology, , 175 (3 ) ,333-40

McGraw, D W; Donnelly, E T; Eason, M G; Green, S A; Liggett, S B (1998. ) Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular signalling, , 10 (3 ) ,197-204

McGraw, D W; Liggett, S B (1997. ) Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of biological chemistry, , 272 (11 ) ,7338-44

McGraw, D W; Jacobi, S E; Hiller, F C; Cornett, L E (1996. ) Structural and functional analysis of the 5'-flanking region of the rat beta 2-adrenergic receptor gene. Biochimica et biophysica acta, , 1305 (3 ) ,135-8

McGraw, D W; Chai, S E; Hiller, F C; Cornett, L E Regulation of the beta 2-adrenergic receptor and its mRNA in the rat lung by dexamethasone. Experimental lung research, , 21 (4 ) ,535-46

Gupta, Nishant; Kralovic, Stephen M; McGraw, Dennis (2014. ) Lemierre syndrome: not so forgotten!.American journal of critical care : an official publication, American Association of Critical-Care Nurses, , 23 (2 ) ,176-9

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A (2012. ) Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3.The Journal of investigative dermatology, , 132 (9 ) ,2255-62

Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T (2020. ) MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis.JCI insight, , 5 (4 ) ,

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X (2015. ) Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.Science translational medicine, , 7 (313 ) ,313ra181

Honors and Awards

1992 Allen & Hanbury's Respiratory Institute Pulmonary Fellowship Award "Regulation of B2-Adrenergic Receptor Gene Expression in the Lung"

1993 Red Sash Teaching Award by graduating seniors University of Arkansas for Medical Sciences

1997 -1999 Fellow NIH Program of Excellence in Molecular Biology, University of Cincinnati

Keywords

lung, respiratory, pulmonology

Contact Information

Academic - Medical Sciences Building
University of Cincinnati
Cincinnati  Ohio, 45267-0564
Phone: 513-558-4831
Fax: 513-558-4858
dennis.mcgraw@uc.edu