Robert  McNamara

Robert McNamara , PhD

Professor

Director, Lipidomics Research Program

UC Department of Psychiatry and Behavioral Neuroscience
PO Box 670559
Cincinnati, Ohio 45267-0559
Phone (513) 558-5601

Professional Summary

DR. ROBERT MCNAMARA is an Associate Professor of Psychiatry at the University of Cincinnati College of Medicine. Dr. McNamara received his PhD from the University of Victoria, Canada, and then completed postdoctoral training in neuropsychopharmacology at Northwestern University and University of Florida before receiving a junior faculty position in the Department of Psychiatry at the University of Pennsylvania School of Medicine. He then moved to Eli Lilly and Company to the Clinical Neuroscience Laboratories where he received additional training in antidepressant research and clinical trial development. He then accepted an Associate Professor position in the Department of Psychiatry at the University of Cincinnati, and is presently in the Division of Bipolar Disorders Research. His laboratory investigates the role of omega-3 fatty acid deficiency in the pathoetiology of recurrent neuropsychiatric disorders using animal models, postmortem brain tissue, and preclinical and clinical neuroimaging techniques. His lab is currently investigating the effects of omega-3 fatty acid supplementation on functional brain activation patterns and symptom severity in children and adolescents with recurrent affective disorders, including major depression and bipolar disorder.

Education

Doctoral Degree: University of Victoria

Post-Doctoral Training: Northwestern University and University of Florida (Neuropsychopharmacology)

Research and Practice Interests

Dr. McNamara's lab investigates the role of omega-3 fatty acid deficiency in the pathoetiology of recurrent neuropsychiatric disorders using animal models, postmortem brain tissue, and preclinical and clinical neuroimaging techniques.

His lab is currently investigating the effects of omega-3 fatty acid supplementation on functional brain activation patterns and symptom severity in children and adolescents with recurrent affective disorders, including major depression and bipolar disorder.

Research Support

Grant: #R34 MH083924 2009 -2012 National Institute of Mental Health Neurochemical effects of omega-3 fatty acids in adolescents at risk for mania Active

2008 -2010 Inflammation Research Foundation Evaluation of omega-3 fatty acids as a treatment-adjunct in adolescent patients with treatment-refractory major depressive disorder: An open-label neuroimaging trial Active

Grant: #RO76477-SCH-0004 2008 -2010 Ortho-McNeil Janssen Pharmaceuticals Preclinical comparison of risperidone and paliperidone on erythrocyte, heart, and prefrontal cortex docosahexaenoic acid (DHA) composition: Relationship to serum triglyceride levels Active

Grant: #RO1 AG03617 2009 -2012 National Institute on Aging Omega-3 and blueberry supplementation in age-related cognitive decline Active

2010 -2012 National Alliance for Research on Schizophrenia and Depression, Independent Investigator Award Peroxisomal defects and risk for bipolar disorder Active

Grant: #1 R21 MH074858-01A1 Investigators:McNamara, Robert 08-01-2006 -07-31-2008 National Institute of Mental Health Brain Fatty Acid Composition and PKC Activity Role:PI $376,777.00 Closed Level:Federal

Grant: #SRS 00599 Investigators:McNamara, Robert 12-18-2006 -02-28-2008 Janssen Pharmaceutica Research Foundation Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia, Brain Fatty Acid Composition and PKC Activity Role:PI $34,000.00 Active Level:Industry

Grant: #R21-MH-073704 Investigators:McNamara, Robert 02-01-2006 -01-31-2008 National Institute of Mental Health Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia Role:PI $374,905.00 Closed Level:Federal

Grant: #SRS 5572 Investigators:McNamara, Robert 04-01-2008 -03-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement - Robert McNamara Role:PI $8,783.00 Active Level:Federal

Grant: #118995 Investigators:McNamara, Robert 08-01-2008 -03-31-2011 Ortho-McNeil Janssen Scientific Affairs LLC Preclinical Comparison of Paliperidone, Quetiapine, and Olanzapine on Erythrocyte, Heart, and Prefrontal Cortex Docosahexaenoic Acid Role:PI $174,754.00 Active Level:Industry

Grant: #ISSERI0002 Investigators:McNamara, Robert 12-01-2008 -11-30-2009 AstraZeneca, PLC. (United Kingdom) Effects of Chronic Quetiapine on Rat Erythrocyte, Heart and Brain Omega-3 Fatty Acid Composition Role:PI $.00 Closed Level:Foreign Industry

Grant: #R34 MH083924 Investigators:Delbello, Melissa; Komoroski, Richard; McNamara, Robert; Nandagopal, Jayasree; Strakowski, Stephen; Welge, Jeffrey 06-15-2009 -12-31-2013 National Institute of Mental Health The Neurochemical Effects of Omega-3 Fatty Acids In Adolescents At Risk For Developing Mania Role:Collaborator $704,020.00 Active Level:Federal

Grant: #R01 AG034617- Investigators:Fleck, David; Krikorian, Robert; McNamara, Robert; Nasrallah, Henry; Welge, Jeffrey 09-30-2009 -08-31-2014 National Institute on Aging Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline Role:Collaborator $1,331,722.00 Active Level:Federal

Grant: #2010 Award Investigators:McNamara, Robert 09-15-2010 -09-15-2013 NARSAD Research Institute, Inc. Peroxisomal Defects and Familial Risk for Bipolar Disorder Role:PI $99,873.00 Active Level:Private Non-Profit

Grant: #500494-CIN-01\ 5P30MH090590-02 Investigators:McNamara, Robert 03-01-2012 -04-30-2013 National Institute of Mental Health Early Phase Psychosis: Informing Treatment Decisions Role:PI $6,848.00 Active Level:Federal

Grant: #R01DK097599 Investigators:Delbello, Melissa; McNamara, Robert; Nasrallah, Amelia; Strawn, Jeffrey; Welge, Jeffrey 07-01-2013 -05-31-2018 National Inst of Diabetes and Digestive and Kidney Disease Risk and Protective Factors for SGA-Induced Metabolic Syndrome in Bipolar Youth Role:PI $335,338.00 Active Level:Federal

Grant: #Study Number 2012-1053 Investigators:McNamara, Robert; Nasrallah, Amelia; Patino, Mario 08-20-2013 -08-19-2014 DSM Nutritional Products, LLC Docosahexaenoic Acid Augmentation of Cortical Attention Networks in ADHD Role:PI $180,000.00 Awarded Level:Industry

Grant: #500494-CIN-01-Amend 2 Investigators:McNamara, Robert 05-01-2014 -04-30-2015 National Institute of Mental Health Early Phase Psychosis: Informing Treatment Decisions Role:PI $17,018.00 Awarded Level:Federal

Grant: #R01MH107378 Investigators:Herman, James; McNamara, Robert; Welge, Jeffrey 03-09-2016 -01-31-2020 National Institute of Mental Health Risk and resilience factors for frontolimbic connectivity deficits Role:PI $464,822.00 Awarded Level:Federal

Grant: #R01MH097818 Investigators:Adler, Caleb; Delbello, Melissa; Eliassen, James; Komoroski, Richard; McNamara, Robert; Strakowski, Stephen; Welge, Jeffrey 07-08-2015 -06-30-2021 National Institute of Mental Health Neuroimaging study of risk factors for adolescent bipolar disorder Role:Collaborator $3,230,092.00 Active Level:Federal

Publications

Peer Reviewed Publications

http://www.ncbi.nlm.nih.gov/pubmed?term=mcnamara%20rk .

McNamara, Robert K; Asch, Ruth H; Lindquist, Diana M; Krikorian, Robert (2017. ) Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings.Prostaglandins, leukotrienes, and essential fatty acids, , More Information

Almeida, Daniel M; Jandacek, Ronald J; Weber, Wade A; McNamara, Robert K (2017. ) Docosahexaenoic acid biostatus is associated with event-related functional connectivity in cortical attention networks of typically developing children.Nutritional neuroscience, , 20 (4 ) ,246-254 More Information

Messamore, Erik; Almeida, Daniel M; Jandacek, Ronald J; McNamara, Robert K (2017. ) Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.Progress in lipid research, , 66 ,1-13 More Information

McNamara, Robert K; Szeszko, Philip R; Smesny, Stefan; Ikuta, Toshikazu; DeRosse, Pamela; Vaz, Frédéric M; Milleit, Berko; Hipler, Uta-Christina; Wiegand, Cornelia; Hesse, Jana; Amminger, G Paul; Malhotra, Anil K; Peters, Bart D (2017. ) Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence.Neuroscience, , 343 ,423-433 More Information

McNamara, Robert K; Moser, Ann B; Jones, Richard I; Jandacek, Ronald; Patino, L Rodrigo; Strawn, Jeffrey R; Strakowski, Stephen M; DelBello, Melissa P (2016. ) Familial risk for bipolar disorder is not associated with impaired peroxisomal function: Dissociation from docosahexaenoic acid deficits.Psychiatry research, , 246 ,803-807 More Information

Welge, Jeffrey A; Saliba, Lawrence J; Strawn, Jeffrey R; Eliassen, James C; Patino, L Rodrigo; Adler, Caleb M; Weber, Wade; Schneider, Marguerite Reid; Barzman, Drew H; Strakowski, Stephen M; DelBello, Melissa P; McNamara, Robert K (2016. ) Neurofunctional Differences Among Youth With and at Varying Risk for Developing Mania.Journal of the American Academy of Child and Adolescent Psychiatry, , 55 (11 ) ,980-989 More Information

McNamara, Robert K (2016. ) Role of Omega-3 Fatty Acids in the Etiology, Treatment, and Prevention of Depression: Current Status and Future Directions.Journal of nutrition & intermediary metabolism, , 5 ,96-106 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P (2016. ) Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker.Early intervention in psychiatry, , 10 (3 ) ,203-11 More Information

McNamara, Robert K; Welge, Jeffrey A (2016. ) Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder.Bipolar disorders, , 18 (3 ) ,300-6 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P (2016. ) Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: a preliminary 1H MRS study.Nutritional neuroscience, , 19 (4 ) ,145-55 More Information

Scola, Gustavo; McNamara, Robert K; Croarkin, Paul E; Leffler, Jarrod M; Cullen, Kathryn R; Geske, Jennifer R; Biernacka, Joanna M; Frye, Mark A; DelBello, Melissa P; Andreazza, Ana C (2016. ) Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder.Journal of affective disorders, , 192 ,176-83 More Information

Lotrich, Francis E; Sears, Barry; McNamara, Robert K (2016. ) Polyunsaturated fatty acids moderate the effect of poor sleep on depression risk.Prostaglandins, leukotrienes, and essential fatty acids, , 106 ,19-25 More Information

Messamore, Erik; McNamara, Robert K (2016. ) Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation.Lipids in health and disease, , 15 ,25 More Information

Lavoie, Suzie; Whitford, Thomas J; Benninger, Franz; Feucht, Martha; Kim, Sung-Wan; Klier, Claudia M; McNamara, Robert K; Rice, Simon; Schäfer, Miriam R; Amminger, G Paul (2016. ) Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis.The Australian and New Zealand journal of psychiatry, , 50 (1 ) ,56-63 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M (2015. ) First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine.Psychiatry research, , 230 (2 ) ,447-53 More Information

McNamara, Robert K; Vannest, Jennifer J; Valentine, Christina J (2015. ) Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology.World journal of psychiatry, , 5 (1 ) ,15-34 More Information

Wehry, Anna M; McNamara, Robert K; Adler, Caleb M; Eliassen, James C; Croarkin, Paul; Cerullo, Michael A; DelBello, Melissa P; Strawn, Jeffrey R (2015. ) Neurostructural impact of co-occurring anxiety in pediatric patients with major depressive disorder: a voxel-based morphometry study.Journal of affective disorders, , 171 ,54-9 More Information

McNamara, Robert K (2015. ) Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids.Journal of the American College of Nutrition, , 34 Suppl 1 ,48-55 More Information

Strawn, Jeffrey R; Adler, Caleb M; McNamara, Robert K; Welge, Jeffrey A; Bitter, Samantha M; Mills, Neil P; Barzman, Drew H; Cerullo, Michael A; Chang, Kiki D; Strakowski, Stephen M; DelBello, Melissa P (2014. ) Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study.Bipolar disorders, , 16 (5 ) ,523-30 More Information

McNamara, Robert K; Strimpfel, Jennifer; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Welge, Jeffrey A; Strawn, Jeffrey R; Delbello, Melissa P (2014. ) Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder.PharmaNutrition, , 2 (2 ) ,38-46 More Information

McNamara, Robert K; Rider, Therese; Jandacek, Ronald; Tso, Patrick (2014. ) Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis.Psychiatry research, , 215 (3 ) ,560-7 More Information

Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K (2014. ) Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression.Journal of psychiatric research, , 50 ,42-50 More Information

McNamara, Robert K; Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W (2013. ) Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats.Pharmacology, biochemistry, and behavior, , 114-115 ,1-8 More Information

Lotrich, Francis E; Sears, Barry; McNamara, Robert K (2013. ) Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.Journal of psychosomatic research, , 75 (5 ) ,475-83 More Information

McNamara, Robert K (2013. ) Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Current drug discovery technologies, , 10 (3 ) ,233-44

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Dwivedi, Yogesh; Ren, Xinguo; Pandey, Ghanshyam N (2013. ) Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease.Journal of psychiatric research, , 47 (9 ) ,1187-91 More Information

Lotrich, Francis E; Sears, Barry; McNamara, Robert K (2013. ) Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6.Brain, behavior, and immunity, , 31 ,48-53 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Weber, Wade; Chu, Wen-Jang; Strakowski, Stephen M; Adler, Caleb M; Delbello, Melissa P (2013. ) Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study.Nutritional neuroscience, , 16 (4 ) ,183-90 More Information

McNamara, Robert K; Strawn, Jeffrey R (2013. ) Role of Long-Chain Omega-3 Fatty Acids in Psychiatric Practice.PharmaNutrition, , 1 (2 ) ,41-49 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N (2013. ) Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk.Cardiovascular psychiatry and neurology, , 2013 ,796462 More Information

McNamara, Robert K (2013. ) Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging.Prostaglandins, leukotrienes, and essential fatty acids, , 88 (1 ) ,33-42 More Information

McNamara, Robert K; Strawn, Jeffrey R; Chang, Kiki D; DelBello, Melissa P (2012. ) Interventions for youth at high risk for bipolar disorder and schizophrenia.Child and adolescent psychiatric clinics of North America, , 21 (4 ) ,739-51 More Information

McNamara, Robert K; Magrisso, I Jack; Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C (2012. ) Omega-3 fatty acid deficiency augments risperidone-induced hepatic steatosis in rats: positive association with stearoyl-CoA desaturase.Pharmacological research, , 66 (4 ) ,283-91 More Information

McNamara, Robert K; Lotrich, Francis E (2012. ) Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?.Expert review of neurotherapeutics, , 12 (9 ) ,1143-61 More Information

Schneider, Marguerite Reid; DelBello, Melissa P; McNamara, Robert K; Strakowski, Stephen M; Adler, Caleb M (2012. ) Neuroprogression in bipolar disorder.Bipolar disorders, , 14 (4 ) ,356-74 More Information

Richtand, Neil M; Ahlbrand, Rebecca; Horn, Paul; Tambyraja, Rabindra; Grainger, Molly; Bronson, Stefanie L; McNamara, Robert K (2012. ) Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response.Physiology & behavior, , 106 (2 ) ,171-7 More Information

Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels.Prostaglandins, leukotrienes, and essential fatty acids, , 86 (1-2 ) ,71-7 More Information

Richtand, Neil M; Ahlbrand, Rebecca; Horn, Paul; Stanford, Kevin; Bronson, Stefanie L; McNamara, Robert K (2011. ) Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation.Journal of psychiatric research, , 45 (9 ) ,1194-201 More Information

Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Magrisso, I Jack; Benoit, Stephen C; McNamara, Robert K (2011. ) Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status.Nutrition research (New York, N.Y.), , 31 (9 ) ,715-22 More Information

McNamara, Robert K (2011. ) Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia?.Schizophrenia research, , 129 (2-3 ) ,215-6 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W (2011. ) Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity.Schizophrenia research, , 129 (1 ) ,66-73 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W (2011. ) Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.Schizophrenia research, , 129 (1 ) ,57-65 More Information

McNamara, Robert K; Liu, Yanhong (2011. ) Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder.Journal of affective disorders, , 129 (1-3 ) ,359-63 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2011. ) Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats.European journal of pharmacology, , 652 (1-3 ) ,152-6 More Information

Liu, Yanhong; McNamara, Robert K (2011. ) Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder.Journal of psychiatric research, , 45 (2 ) ,269-72 More Information

McNamara, Robert K; Jandacek, Ronald (2011. ) Investigation of postmortem brain polyunsaturated fatty acid composition in psychiatric disorders: limitations, challenges, and future directions.Journal of psychiatric research, , 45 (1 ) ,44-6 More Information

McNamara, Robert K; Nandagopal, Jayasree J; Strakowski, Stephen M; DelBello, Melissa P (2010. ) Preventative strategies for early-onset bipolar disorder: towards a clinical staging model.CNS drugs, , 24 (12 ) ,983-96 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N (2010. ) Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder.Journal of affective disorders, , 126 (1-2 ) ,303-11 More Information

McNamara, Robert K; Able, Jessica A; Rider, Therese; Tso, Patrick; Jandacek, Ronald (2010. ) Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition.Progress in neuro-psychopharmacology & biological psychiatry, , 34 (7 ) ,1317-21 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover.Prostaglandins, leukotrienes, and essential fatty acids, , 83 (4-6 ) ,185-91 More Information

Richtand, Neil M; Liu, Yanhong; Ahlbrand, Rebecca; Sullivan, Juliana R; Newman, Amy Hauck; McNamara, Robert K (2010. ) Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression.Synapse (New York, N.Y.), , 64 (8 ) ,634-43 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Eliassen, James C; Alfieri, David; Weber, Wade; Jarvis, Kelly; DelBello, Melissa P; Strakowski, Stephen M; Adler, Caleb M (2010. ) Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study.The American journal of clinical nutrition, , 91 (4 ) ,1060-7 More Information

McNamara, Robert K (2010. ) DHA deficiency and prefrontal cortex neuropathology in recurrent affective disorders.The Journal of nutrition, , 140 (4 ) ,864-8 More Information

McNamara, Robert K Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations.Prostaglandins, leukotrienes, and essential fatty acids, , 81 (2-3 ) ,223-31 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition.Psychoneuroendocrinology, , 34 (4 ) ,532-9 More Information

Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K (2009. ) Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition.Schizophrenia research, , 109 (1-3 ) ,113-20 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lindquist, Diana M (2009. ) Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.Journal of lipid research, , 50 (3 ) ,405-11 More Information

McNamara, Robert K; Able, Jessica; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W (2009. ) Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects.Journal of psychiatric research, , 43 (6 ) ,656-63 More Information

McNamara, Robert K; Able, Jessica A; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis.Schizophrenia research, , 107 (2-3 ) ,150-7 More Information

McNamara, Robert K (2009. ) Membrane omega-3 Fatty Acid deficiency as a preventable risk factor for comorbid coronary heart disease in major depressive disorder.Cardiovascular psychiatry and neurology, , 2009 ,362795 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition.Lipids, , 44 (1 ) ,1-8 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Roberts, Rosalinda C; Conley, Robert R; Pandey, Ghanshyam N (2009. ) Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims.Prostaglandins, leukotrienes, and essential fatty acids, , 80 (1 ) ,19-26 More Information

McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Campbell, Nick; Lipton, Jack (2008. ) Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations.Synapse (New York, N.Y.), , 62 (10 ) ,725-35 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Hahn, Chang-Gyu; Richtand, Neil M (2008. ) Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder.Psychiatry research, , 160 (3 ) ,285-99 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2008. ) WITHDRAWN: Published in error by the publisher: Constitutive differences in regional brain fatty acid content of inbred C57BL/6J and DBA/2J mouse strains.Journal of lipid research, , More Information

McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M (2008. ) Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment.Journal of psychiatric research, , 42 (6 ) ,458-68 More Information

McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity.Prostaglandins, leukotrienes, and essential fatty acids, , 78 (4-5 ) ,293-304 More Information

Richtand, Neil M; Welge, Jeffrey A; Logue, Aaron D; Keck, Paul E; Strakowski, Stephen M; McNamara, Robert K (2008. ) Role of serotonin and dopamine receptor binding in antipsychotic efficacy.Progress in brain research, , 172 ,155-75 More Information

Richtand, Neil M; McNamara, Robert K (2008. ) Serotonin and dopamine interactions in psychosis prevention.Progress in brain research, , 172 ,141-53 More Information

Richtand, Neil M; Welge, Jeffrey A; Logue, Aaron D; Keck, Paul E; Strakowski, Stephen M; McNamara, Robert K (2007. ) Dopamine and serotonin receptor binding and antipsychotic efficacy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 32 (8 ) ,1715-26 More Information

McNamara, Robert K; Hahn, Chang-Gyu; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Richtand, Neil M (2007. ) Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder.Biological psychiatry, , 62 (1 ) ,17-24 More Information

Pritchard, Laurel M; Newman, Amy Hauck; McNamara, Robert K; Logue, Aaron D; Taylor, Benjamin; Welge, Jeffrey A; Xu, Ming; Zhang, Jianhua; Richtand, Neil M (2007. ) The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion.Pharmacology, biochemistry, and behavior, , 86 (4 ) ,718-26 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Hahn, Chang-Gyu; Richtand, Neil M; Stanford, Kevin E (2007. ) Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications.Schizophrenia research, , 91 (1-3 ) ,37-50 More Information

McNamara, Robert K; Carlson, Susan E Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology.Prostaglandins, leukotrienes, and essential fatty acids, , 75 (4-5 ) ,329-49 More Information

McNamara, Robert K; Ostrander, Michelle; Abplanalp, William; Richtand, Neil M; Benoit, Stephen C; Clegg, Debbie J Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness.Prostaglandins, leukotrienes, and essential fatty acids, , 75 (4-5 ) ,237-57 More Information

McNamara, Robert K The emerging role of omega-3 fatty acids in psychiatry.Prostaglandins, leukotrienes, and essential fatty acids, , 75 (4-5 ) ,223-5 More Information

McNamara, Robert K; Logue, Aaron; Stanford, Kevin; Xu, Ming; Zhang, Jianhua; Richtand, Neil M (2006. ) Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine.Synapse (New York, N.Y.), , 60 (5 ) ,399-405 More Information

Hussain, Rifat J; Stumpo, Deborah J; Blackshear, Perry J; Lenox, Robert H; Abel, Ted; McNamara, Robert K (2006. ) Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation.Hippocampus, , 16 (5 ) ,495-503 More Information

Richtand, Neil M; Taylor, Benjamin; Welge, Jeffrey A; Ahlbrand, Rebecca; Ostrander, Michelle M; Burr, Jeffrey; Hayes, Scott; Coolen, Lique M; Pritchard, Laurel M; Logue, Aaron; Herman, James P; McNamara, Robert K (2006. ) Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 31 (1 ) ,77-89 More Information

Delgado, Pedro L; Brannan, Stephen K; Mallinckrodt, Craig H; Tran, Pierre V; McNamara, Robert K; Wang, Fujun; Watkin, John G; Detke, Michael J (2005. ) Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. The Journal of clinical psychiatry, , 66 (6 ) ,686-92

McNamara, Robert K; Hussain, Rifat J; Simon, Erica J; Stumpo, Deborah J; Blackshear, Perry J; Abel, Ted; Lenox, Robert H (2005. ) Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice.Hippocampus, , 15 (5 ) ,675-83 More Information

Detke, Michael J; Wiltse, Curtis G; Mallinckrodt, Craig H; McNamara, Robert K; Demitrack, Mark A; Bitter, Istvan (2004. ) Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, , 14 (6 ) ,457-70 More Information

McNamara, Robert K; Lenox, Robert H (2004. ) Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice.Neuroscience letters, , 368 (3 ) ,293-6 More Information

Greist, John; McNamara, Robert K; Mallinckrodt, Craig H; Rayamajhi, Jyoti N; Raskin, Joel (2004. ) Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine.Clinical therapeutics, , 26 (9 ) ,1446-55 More Information

Bymaster, Frank P; McNamara, Robert K; Tran, Pierre V (2003. ) New approaches to developing antidepressants by enhancing monoaminergic neurotransmission.Expert opinion on investigational drugs, , 12 (4 ) ,531-43 More Information

McNamara, Robert K; Vasquez, Patricia A; Mathe, Aleksander A; Lenox, Robert H (2003. ) Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice. Journal of neurochemistry, , 85 (2 ) ,462-8

Tran, Pierre V; Bymaster, Frank P; McNamara, Robert K; Potter, William Z (2003. ) Dual monoamine modulation for improved treatment of major depressive disorder. Journal of clinical psychopharmacology, , 23 (1 ) ,78-86

Detke, Michael J; Lu, Yili; Goldstein, David J; McNamara, Robert K; Demitrack, Mark A Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression. Journal of psychiatric research, , 36 (6 ) ,383-90

Huot, Rebecca L; Plotsky, Paul M; Lenox, Robert H; McNamara, Robert K (2002. ) Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain research, , 950 (1-2 ) ,52-63

Krucker, Thomas; Siggins, George R; McNamara, Robert K; Lindsley, Kristen A; Dao, Alan; Allison, David W; De Lecea, Luis; Lovenberg, Timothy W; Sutcliffe, J Gregor; Gerendasy, Dan D (2002. ) Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 22 (13 ) ,5525-35 More Information

McNamara, Robert K; Huot, Rebecca L; Lenox, Robert H; Plotsky, Paul M (2002. ) Postnatal maternal separation elevates the expression of the postsynaptic protein kinase C substrate RC3, but not presynaptic GAP-43, in the developing rat hippocampus.Developmental neuroscience, , 24 (6 ) ,485-94 More Information

McNamara, R K; Jiang, Y; Streit, W J; Lenox, R H (2000. ) Facial motor neuron regeneration induces a unique spatial and temporal pattern of myristoylated alanine-rich C kinase substrate expression. Neuroscience, , 97 (3 ) ,581-9

McNamara, R K; Wees, E A; Lenox, R H (1999. ) Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid. Journal of neurochemistry, , 72 (4 ) ,1735-43

Kinney, W R; McNamara, R K; Valcourt, E; Routtenberg, A (1996. ) Prolonged alteration in E-box binding after a single systemic kainate injection: potential relation to F1/GAP-43 gene expression. Brain research. Molecular brain research, , 38 (1 ) ,25-36

McNamara, R K; Whishaw, I Q (1990. ) Blockade of hoarding in rats by diazepam: an analysis of the anxiety and object value hypotheses of hoarding. Psychopharmacology, , 101 (2 ) ,214-21

McNamara, Robert K; Almeida, Daniel M (2019. ) Omega-3 Polyunsaturated Fatty Acid Deficiency and Progressive Neuropathology in Psychiatric Disorders: A Review of Translational Evidence and Candidate Mechanisms.Harvard review of psychiatry, , More Information

Wulsin, Lawson R; Blom, Thomas J; Durling, Michelle; Welge, Jeffrey A; DelBello, Melissa P; Adler, Caleb M; McNamara, Robert K; Strakowski, Stephen M (2018. ) Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder.Bipolar disorders, , 20 (7 ) ,658-665 More Information

Robinson, Delbert G; Gallego, Juan A; John, Majnu; Hanna, Lauren A; Zhang, Jian-Ping; Birnbaum, Michael L; Greenberg, Jessica; Naraine, Melissa; Peters, Bart D; McNamara, Robert K; Malhotra, Anil K; Szeszko, Philip R (2018. ) A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16?week randomized placebo-controlled trial for participants concurrently treated with risperidone.Schizophrenia research, , More Information

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang (2018. ) An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination.Cell reports, , 23 (12 ) ,3607-3620 More Information

McNamara, Robert K; Kalt, Wilhelmina; Shidler, Marcelle D; McDonald, Jane; Summer, Suzanne S; Stein, Amanda L; Stover, Amanda N; Krikorian, Robert (2018. ) Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment.Neurobiology of aging, , 64 ,147-156 More Information

Luft, Marissa J; Lamy, Martine; DelBello, Melissa P; McNamara, Robert K; Strawn, Jeffrey R (2018. ) Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.Current problems in pediatric and adolescent health care, , 48 (2 ) ,50-62 More Information

Paterson, Janis; Medvedev, Oleg N; Sumich, Alexander; Tautolo, El-Shadan; Krägeloh, Christian U; Sisk, Rose; McNamara, Robert K; Berk, Michael; Narayanan, Ajit; Siegert, Richard J (2018. ) Distinguishing transient versus stable aspects of depression in New Zealand Pacific Island children using Generalizability Theory.Journal of affective disorders, , 227 ,698-704 More Information

McNamara, Robert K; Schurdak, Jennifer D; Asch, Ruth H; Peters, Bart D; Lindquist, Diana M (2018. ) Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study.Developmental neuroscience, , 40 (1 ) ,84-92 More Information

McNamara, Robert K; Asch, Ruth H; Schurdak, Jennifer D; Lindquist, Diana M (2017. ) Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo1H MRS study.Psychiatry research. Neuroimaging, , 270 ,39-45 More Information

McNamara, Robert K; Schurdak, Jennifer D; Asch, Ruth H; Lindquist, Diana M (2017. ) Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study.Nutritional neuroscience, , 1-9 More Information

Lindquist, Diana M; Asch, Ruth H; Schurdak, Jennifer D; McNamara, Robert K (2017. ) Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo31P MRS study.Journal of psychiatric research, , 95 ,143-146 More Information

Boespflug, E L; McNamara, R K; Eliassen, J C; Schidler, M D; Krikorian, R (2016. ) Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment.The journal of nutrition, health & aging, , 20 (2 ) ,161-9 More Information

Amminger, G P; Mechelli, A; Rice, S; Kim, S-W; Klier, C M; McNamara, R K; Berk, M; McGorry, P D; Schäfer, M R (2015. ) Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids.Translational psychiatry, , 5 ,e495 More Information

McNamara, R K; Levant, B; Taylor, B; Ahlbrand, R; Liu, Y; Sullivan, J R; Stanford, K; Richtand, N M (2006. ) C57BL/6J mice exhibit reduced dopamine D3 receptor-mediated locomotor-inhibitory function relative to DBA/2J mice.Neuroscience, , 143 (1 ) ,141-53 More Information

McNamara, R K; Lenox, R H (2000. ) Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization.Journal of neuroscience research, , 62 (3 ) ,416-26 More Information

Ramakers, G M; McNamara, R K; Lenox, R H; De Graan, P N (1999. ) Differential changes in the phosphorylation of the protein kinase C substrates myristoylated alanine-rich C kinase substrate and growth-associated protein-43/B-50 following Schaffer collateral long-term potentiation and long-term depression. Journal of neurochemistry, , 73 (5 ) ,2175-83

Klein, R L; McNamara, R K; King, M A; Lenox, R H; Muzyczka, N; Meyer, E M (1999. ) Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer. Brain research, , 832 (1-2 ) ,136-44

Petitto, J M; McNamara, R K; Gendreau, P L; Huang, Z; Jackson, A J (1999. ) Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion.Journal of neuroscience research, , 56 (4 ) ,441-6 More Information

McNamara, R K; Hyde, T M; Kleinman, J E; Lenox, R H (1999. ) Expression of the myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) in the prefrontal cortex and hippocampus of suicide victims. The Journal of clinical psychiatry, , 60 Suppl 2 ,21-6; discussion 40-

McNamara, R K; Stumpo, D J; Morel, L M; Lewis, M H; Wakeland, E K; Blackshear, P J; Lenox, R H (1998. ) Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background.Proceedings of the National Academy of Sciences of the United States of America, , 95 (24 ) ,14517-22 More Information

Harrison, J K; Jiang, Y; Chen, S; Xia, Y; Maciejewski, D; McNamara, R K; Streit, W J; Salafranca, M N; Adhikari, S; Thompson, D A; Botti, P; Bacon, K B; Feng, L (1998. ) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.Proceedings of the National Academy of Sciences of the United States of America, , 95 (18 ) ,10896-901 More Information

McNamara, R K; Lenox, R H (1998. ) Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain. The Journal of comparative neurology, , 397 (3 ) ,337-56

Lenox, R H; McNamara, R K; Papke, R L; Manji, H K (1998. ) Neurobiology of lithium: an update. The Journal of clinical psychiatry, , 59 Suppl 6 ,37-47

McNamara, R K; Lenox, R H (1997. ) Comparative distribution of myristoylated alanine-rich C kinase substrate (MARCKS) and F1/GAP-43 gene expression in the adult rat brain. The Journal of comparative neurology, , 379 (1 ) ,48-71

McNamara, R K; Skelton, R W (1997. ) Tolerance develops to the spatial learning deficit produced by diazepam in rats. Pharmacology, biochemistry, and behavior, , 56 (3 ) ,383-9

Gilbert, T H; McNamara, R K; Corcoran, M E (1996. ) Kindling of hippocampal field CA1 impairs spatial learning and retention in the Morris water maze. Behavioural brain research, , 82 (1 ) ,57-66

McNamara, R K; Namgung, U; Routtenberg, A (1996. ) Distinctions between hippocampus of mouse and rat: protein F1/GAP-43 gene expression, promoter activity, and spatial memory. Brain research. Molecular brain research, , 40 (2 ) ,177-87

McNamara, R K; Davis, T M; Skelton, R W (1996. ) Effect of aging on the spatial learning deficit produced by diazepam in rats. Progress in neuro-psychopharmacology & biological psychiatry, , 20 (5 ) ,873-81

McNamara, R K; Skelton, R W (1996. ) Baclofen, a selective GABAB receptor agonist, dose-dependently impairs spatial learning in rats. Pharmacology, biochemistry, and behavior, , 53 (2 ) ,303-8

Lenox, R H; McNamara, R K; Watterson, J M; Watson, D G (1996. ) Myristoylated alanine-rich C kinase substrate (MARCKS): a molecular target for the therapeutic action of mood stabilizers in the brain? .The Journal of clinical psychiatry, , 57 Suppl 13 ,23-31; discussion 32

McNamara, R K; Routtenberg, A (1995. ) NMDA receptor blockade prevents kainate induction of protein F1/GAP-43 mRNA in hippocampal granule cells and subsequent mossy fiber sprouting in the rat. Brain research. Molecular brain research, , 33 (1 ) ,22-8

McNamara, R K; Skelton, R W (1993. ) Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. II. Neuropharmacological specificity. Behavioural brain research, , 59 (1-2 ) ,193-204

McNamara, R K; Skeleton, R W (1993. ) Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. I. Neuroanatomical specificity. Behavioural brain research, , 59 (1-2 ) ,175-91

McNamara, R K; dePape, G E; Skelton, R W (1993. ) Differential effects of benzodiazepine receptor agonists on hippocampal long-term potentiation and spatial learning in the Morris water maze. Brain research, , 626 (1-2 ) ,63-70

McNamara, R K; Corcoran, M E (1993. ) CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil. Epilepsy research, , 16 (1 ) ,19-26

McNamara, R K; Kirkby, R D; dePape, G E; Skelton, R W; Corcoran, M E (1993. ) Differential effects of kindling and kindled seizures on place learning in the Morris water maze.Hippocampus, , 3 (2 ) ,149-52 More Information

McNamara, R K; Skelton, R W The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain research. Brain research reviews, , 18 (1 ) ,33-49

McNamara, R K; Kirkby, R D; dePape, G E; Corcoran, M E (1992. ) Limbic seizures, but not kindling, reversibly impair place learning in the Morris water maze. Behavioural brain research, , 50 (1-2 ) ,167-75

McNamara, R K; Skelton, R W (1992. ) Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze. Pharmacology, biochemistry, and behavior, , 41 (3 ) ,529-38

Skelton, R W; McNamara, R K (1992. ) Bilateral knife cuts to the perforant path disrupt spatial learning in the Morris water maze.Hippocampus, , 2 (1 ) ,73-80 More Information

McNamara, R K; Skelton, R W (1992. ) Pharmacological dissociation between the spatial learning deficits produced by morphine and diazepam. Psychopharmacology, , 108 (1-2 ) ,147-52

McNamara, R K; Skelton, R W (1992. ) Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology, , 107 (2-3 ) ,347-51

McNamara, R K; Skelton, R W (1991. ) Diazepam impairs acquisition but not performance in the Morris water maze. Pharmacology, biochemistry, and behavior, , 38 (3 ) ,651-8

Whishaw, I Q; Oddie, S D; McNamara, R K; Harris, T L; Perry, B S (1990. ) Psychophysical methods for study of sensory-motor behavior using a food-carrying (hoarding) task in rodents. Journal of neuroscience methods, , 32 (2 ) ,123-33

McNamara R.;Schurdak J.;Asch R.;Lindquist D. (12-30-2017. ) Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine trea.Nutritional Neuroscience, , 1-9 More Information

McNamara R. (09-01-2016. ) Role of Omega-3 fatty acids in the etiology, treatment, and prevention of depression: Current status.Journal of Nutrition and Intermediary Metabolism, , 5 ,96-106 More Information

McNamara R.K. (12-04-2015. ) Role of dietary fatty acids in mood disorders.Handbook of Lipids in Human Function: Fatty Acids, , 423-456 More Information

Mcnamara R. (01-01-2015. ) Dietary fats and mood disorders - translating research into practice.Lipid Technology, , 27 (11 ) ,251-254 More Information

McNamara R.;Valentine C. (01-01-2015. ) Role of long-chain omega-3 fatty acids in cognitive and emotional development .Nutrition for Brain Health and Cognitive Performance, , 151-187

Barzman D.;Eliassen J.;McNamara R.;Abonia P.;Mossman D.;Durling M.;Adler C.;DelBello M.;Lin P. (11-30-2014. ) Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in p.Psychiatry Research - Neuroimaging, , 224 (2 ) ,107-111 More Information

McNamara R.;Strimpfel J.;Jandacek R.;Rider T.;Tso P.;Welge J.;Strawn J.;DelBello M. (01-01-2014. ) Detection and treatment of long-chain omega-3 fatty acid deficiency in adolescents with SSRI-resista.PharmaNutrition, , 2 (2 ) ,38-46 More Information

McNamara R. (05-01-2013. ) Developmental long-chain omega-3 fatty acid deficiency and prefrontal cortex pathology in psychiatri .Prefrontal Cortex: Developmental Differences, Executive and Cognitive Functions and Role in Neurological Disorders, , 1-38

McNamara R.;Jandacek R.;Rider T.;Tso P.;Dwivedi Y.;Pandey G. (04-03-2013. ) Adult medication-free schizophrenic patients exhibit long-chain omega-3 fatty acid deficiency: Impli.Cardiovascular Psychiatry and Neurology, , 2013 , More Information

McNamara R.;Strawn J. (04-01-2013. ) Role of long-chain omega-3 fatty acids in psychiatric practice.PharmaNutrition, , 1 (2 ) ,41-49 More Information

McNamara R. (03-01-2013. ) The omega-3 fatty acid deficiency syndrome: Opportunities for disease prevention .The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention, , 1-445

McNamara R. (03-01-2013. ) The Omega-3 Deficiency Syndrome .The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention, ,

McNamara R.;Jandacek R.;Tso P.;Dwivedi Y.;Ren X.;Pandey G. (01-01-2013. ) Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed sui.Journal of Psychiatric Research, , 47 (9 ) ,1187-1191 More Information

McNamara R.;Jandacek R.;Tso P.;Weber W.;Chu W.;Strakowski S.;Adler C.;Delbello M. (01-01-2013. ) Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the ante.Nutritional Neuroscience, , 16 (4 ) ,183-190 More Information

McNamara R. (12-20-2012. ) Depressive disorders and inflammation .Nutrition and Physical Activity in Inflammatory Diseases, , 273-298

McNamara R. (12-01-2009. ) Modulation of polyunsaturated fatty acid biosynthesis by antipsychotic medications: Implications for.Clinical Lipidology, , 4 (6 ) ,809-820 More Information

McNamara R.;Lenox R. (01-01-2004. ) The myristoylated alanine-rich C kinase substrate: A lithium-regulated protein linking cellular sign.Clinical Neuroscience Research, , 4 (3-4 SPEC. ISS. ) ,155-169 More Information

Manji H.K.;McNamara R.;Chen G.;Lenox R.H. (12-01-1999. ) Signalling pathways in the brain: Cellular transduction of mood stabilisation in the treatment of ma.Australian and New Zealand Journal of Psychiatry, , 33 (SUPPL. ) , More Information

McNamara R.K.;Skelton R.W. (01-01-1993. ) Benzodiazepine receptor antagonists flumazenil and CGS 8216 and inverse-agonist ?-CCM nhance spatial.Psychobiology, , 21 (2 ) ,101-108 More Information

McNamara R.K.;Skelton R.W. (01-01-1991. ) Pretraining morphine impairs acquisition and performance in the Morris water maze: Motivation reduct.Psychobiology, , 19 (4 ) ,313-322 More Information

Professional Affiliation

2006 -To Present: NIH Fogarty International Brain Disorders Study Section

2005 -To Present: NIH Pharmacology & Diagnostics for Neuropsychiatric Disorders Study Section

2006 -To Present: Ad hoc reviewer National Science Foundation

Contact Information

Academic - UC Department of Psychiatry and Behavioral Neuroscience
PO Box 670559
Cincinnati  Ohio, 45267-0559
Phone: (513) 558-5601