Jayme McReynolds

Jayme Rose McReynolds

Assistant Professor

Professional Summary

Dr. McReynolds received her PhD in Cognition & Neuroscience from the University of Texas at Dallas in 2012 under the mentorship of Dr. Christa McIntyre. She then completed her postdoctoral training with Dr. John Mantsch in the Department of Biomedical Sciences at Marquette University before being promoted to Research Assistant Professor in 2018. She is currently an Assistant Professor in the Department of Pharmacology and Systems Physiology at the University of Cincinnati College of Medicine. Research in her laboratory focuses on the neurobiological mechanisms that underlie the influence of stress on the brain, addictive behavior, and cognitive processes in rodents. 

Education

BS, University of California, Irvine Irvine, CA, 2004 (Major: Biology with a concentration in Neuroscience Minor: Psychology)

MS, University of Texas at Dallas Richardson, TX, 2009 (Applied Cognition and Neuroscience)

PhD, University of Texas at Dallas Richardson, TX, 2012 (Cognition and Neuroscience)

Research Support

Grant: #K01DA045295 Investigators:McReynolds (PI) 05-01-2018 -04-30-2021 NIDA Recruitment of endocannabinoid signaling in the ventral tegmental area and stress-induced escalation of cocaine intake Role:PI 416,093 Active Type:Grant

Grant: #K01DA045295 Investigators:McReynolds, Jayme 05-01-2020 -04-30-2021 National Institute on Drug Abuse Recruitment of endocannabinoid signaling in the ventral tegmental area and stressinduced escalation of cocaine intake Role:PI $136,468.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Vranjkovic, Oliver; Van Newenhizen, Erik C; Nordness, Michael E; Blacktop, Jordan M; Urbanik, Luke A; Mathy, Jacob C; McReynolds, Jayme R; Miller, Anna M; Doncheck, Elizabeth M; Kloehn, Tyler M; Stinnett, Gwen S; Gerndt, Clayton H; Ketchesin, Kyle D; Baker, David A; Seasholtz, Audrey F; Mantsch, John R (2018. )Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience, ,38 (50 ),10657-10671

McReynolds, Jayme R; Doncheck, Elizabeth M; Li, Yan; Vranjkovic, Oliver; Graf, Evan N; Ogasawara, Daisuke; Cravatt, Benjamin F; Baker, David A; Liu, Qing-Song; Hillard, Cecilia J; Mantsch, John R (2018. )Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.Biological psychiatry, ,84 (2 ),85-94

McReynolds, Jayme R; Christianson, John P; Blacktop, Jordan M; Mantsch, John R (2018. )What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders.Neurobiology of stress, ,9 ,271-285

McReynolds, Jayme R; Taylor, Analisa; Vranjkovic, Oliver; Ambrosius, Terra; Derricks, Olivia; Nino, Brittany; Kurtoglu, Beliz; Wheeler, Robert A; Baker, David A; Gasser, Paul J; Mantsch, John R (2017. )Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, ,42 (3 ),757-765

McReynolds, Jayme R; Doncheck, Elizabeth M; Vranjkovic, Oliver; Ganzman, Geoffrey S; Baker, David A; Hillard, Cecilia J; Mantsch, John R (2016. )CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.Psychopharmacology, ,233 (1 ),99-109

McReynolds, Jayme R; Anderson, Kelly M; Donowho, Kyle M; McIntyre, Christa K (2014. )Noradrenergic actions in the basolateral complex of the amygdala modulate Arc expression in hippocampal synapses and consolidation of aversive and non-aversive memory.Neurobiology of learning and memory, ,115 ,49-57

McReynolds, Jayme R; Vranjkovic, Oliver; Thao, Malia; Baker, David A; Makky, Khadijah; Lim, Yiwei; Mantsch, John R (2014. )Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice.Psychopharmacology, ,231 (20 ),3953-63

McReynolds, Jayme R; Holloway-Erickson, Crystal M; Parmar, Tulja U; McIntyre, Christa K (2014. )Corticosterone-induced enhancement of memory and synaptic Arc protein in the medial prefrontal cortex.Neurobiology of learning and memory, ,112 ,148-57

Mantsch, John R; Vranjkovic, Oliver; Twining, Robert C; Gasser, Paul J; McReynolds, Jayme R; Blacktop, Jordan M (2014. )Neurobiological mechanisms that contribute to stress-related cocaine use.Neuropharmacology, ,76 Pt B ,383-94

McReynolds, Jayme R; Peña, David F; Blacktop, Jordan M; Mantsch, John R (2014. )Neurobiological mechanisms underlying relapse to cocaine use: contributions of CRF and noradrenergic systems and regulation by glucocorticoids.Stress (Amsterdam, Netherlands), ,17 (1 ),22-38

Graf, Evan N; Wheeler, Robert A; Baker, David A; Ebben, Amanda L; Hill, Jonathan E; McReynolds, Jayme R; Robble, Mykel A; Vranjkovic, Oliver; Wheeler, Daniel S; Mantsch, John R; Gasser, Paul J (2013. )Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience, ,33 (29 ),11800-10

Holloway-Erickson, Crystal M; McReynolds, Jayme R; McIntyre, Christa K (2012. )Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKII? protein expression in the rostral anterior cingulate cortex.Frontiers in behavioral neuroscience, ,6 ,17

McReynolds, Jayme R; McIntyre, Christa K (2012. )Emotional modulation of the synapse.Reviews in the neurosciences, ,23 (5-6 ),449-61

McReynolds, Jayme R; Donowho, Kyle; Abdi, Amin; McGaugh, James L; Roozendaal, Benno; McIntyre, Christa K (2010. )Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.Neurobiology of learning and memory, ,93 (3 ),312-21

Roozendaal, Benno; McReynolds, Jayme R; Van der Zee, Eddy A; Lee, Sangkwan; McGaugh, James L; McIntyre, Christa K (2009. )Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience, ,29 (45 ),14299-308

Alkire, Michael T; Gruver, Robin; Miller, Jason; McReynolds, Jayme R; Hahn, Emily L; Cahill, Larry (2008. )Neuroimaging analysis of an anesthetic gas that blocks human emotional memory.Proceedings of the National Academy of Sciences of the United States of America, ,105 (5 ),1722-7

Alkire, Michael T; McReynolds, Jayme R; Hahn, Emily L; Trivedi, Akash N (2007. )Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat.Anesthesiology, ,107 (2 ),264-72

Alkire, Michael T; Nathan, Sheila V; McReynolds, Jayme R (2005. )Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats.Anesthesiology, ,103 (6 ),1167-73

Nathan, Sheila V; Griffith, Qyana K; McReynolds, Jayme R; Hahn, Emily L; Roozendaal, Benno (2004. )Basolateral amygdala interacts with other brain regions in regulating glucocorticoid effects on different memory functions.Annals of the New York Academy of Sciences, ,1032 ,179-82

Roozendaal, Benno; McReynolds, Jayme R; McGaugh, James L (2004. )The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience, ,24 (6 ),1385-92

Post Graduate Training and Education

02-2018-10-2019 Research Assistant Professor, Marquette University - Department of Biomedical Sciences, ,Milwaukee, WI

05-2012-Bad Format: 201820## Postdoctoral Fellow, Postdoctoral Fellow in the laboratory of Dr. John Mantsch, Marquette University - Department of Biomedical Sciences, ,Milwaukee, WI

Contact Information

Research - Reading Campus
2120 Galbraith Rd
Cincinnati  Ohio, 45237
Phone: 513-558-6893
Fax: 513-297-0966
jayme.mcreynolds@uc.edu