Jayme Rose McReynolds

Dr. McReynolds received her PhD in Cognition & Neuroscience from the University of Texas at Dallas in 2012 under the mentorship of Dr. Christa McIntyre. She then completed her postdoctoral training with Dr. John Mantsch in the Department of Biomedical Sciences at Marquette University before being promoted to Research Assistant Professor in 2018. She is currently an Assistant Professor in the Department of Pharmacology and Systems Physiology at the University of Cincinnati College of Medicine. Research in her laboratory focuses on the neurobiological mechanisms that underlie the influence of stress on the brain, addictive behavior, and cognitive processes in rodents. 

Bachelor's Degree: University of California, Irvine Irvine, CA, 2004 (Major: Biology with a concentration in Neuroscience Minor: Psychology)

Master's Degree: University of Texas at Dallas Richardson, TX, 2009 (Applied Cognition and Neuroscience)

Doctoral Degree: University of Texas at Dallas Richardson, TX, 2012 (Cognition and Neuroscience)

Postdoctoral Fellow: Marquette University Milwaukee, WI, 2018

Grant: #K01DA045295 Investigators:McReynolds (PI) 05-01-2018 -04-30-2021 NIDA Recruitment of endocannabinoid signaling in the ventral tegmental area and stress-induced escalation of cocaine intake Role:PI 416,093 Active Type:Grant

Grant: #K01DA045295 Investigators:McReynolds, Jayme 05-01-2020 -04-30-2021 National Institute on Drug Abuse Recruitment of endocannabinoid signaling in the ventral tegmental area and stressinduced escalation of cocaine intake Role:PI $136,468.00 Awarded Level:Federal

Grant: #N/A Investigators:McReynolds, Jayme 01-01-2021 -01-31-2021 UC's Launch Awards Research Launch Awards (January 2020 class of faculty) Role:PI $2,500.00 Active Level:Internal UC

Grant: #R01DA057944 Investigators:; McReynolds, Jayme 09-15-2023 -09-15-2024 National Institute on Drug Abuse 1R01DA057944-01A1 -- JIT REQUESTED Role:PI 0.00 Hold Level:Federal

Grant: #R01DA057944 03-01-2024 -01-31-2025 National Institute on Drug Abuse Role of Prelimbic Cortical Endocannabinoid Signaling in Enhanced Cocaine-seeking Behavior Following Combined Repeated Stress and Cocaine Use in Rats Role:PI $440,054.00 Active

Peer Reviewed Publications

Vranjkovic, Oliver; Van Newenhizen, Erik C; Nordness, Michael E; Blacktop, Jordan M; Urbanik, Luke A; Mathy, Jacob C; McReynolds, Jayme R; Miller, Anna M; Doncheck, Elizabeth M; Kloehn, Tyler M; Stinnett, Gwen S; Gerndt, Clayton H; Ketchesin, Kyle D; Baker, David A; Seasholtz, Audrey F; Mantsch, John R (2018. ) Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 38 (50 ) ,10657-10671 More Information

McReynolds, Jayme R; Doncheck, Elizabeth M; Li, Yan; Vranjkovic, Oliver; Graf, Evan N; Ogasawara, Daisuke; Cravatt, Benjamin F; Baker, David A; Liu, Qing-Song; Hillard, Cecilia J; Mantsch, John R (2018. ) Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.Biological psychiatry, , 84 (2 ) ,85-94 More Information

McReynolds, Jayme R; Christianson, John P; Blacktop, Jordan M; Mantsch, John R (2018. ) What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders.Neurobiology of stress, , 9 ,271-285 More Information

McReynolds, Jayme R; Taylor, Analisa; Vranjkovic, Oliver; Ambrosius, Terra; Derricks, Olivia; Nino, Brittany; Kurtoglu, Beliz; Wheeler, Robert A; Baker, David A; Gasser, Paul J; Mantsch, John R (2017. ) Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 42 (3 ) ,757-765 More Information

McReynolds, Jayme R; Doncheck, Elizabeth M; Vranjkovic, Oliver; Ganzman, Geoffrey S; Baker, David A; Hillard, Cecilia J; Mantsch, John R (2016. ) CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.Psychopharmacology, , 233 (1 ) ,99-109 More Information

McReynolds, Jayme R; Anderson, Kelly M; Donowho, Kyle M; McIntyre, Christa K (2014. ) Noradrenergic actions in the basolateral complex of the amygdala modulate Arc expression in hippocampal synapses and consolidation of aversive and non-aversive memory.Neurobiology of learning and memory, , 115 ,49-57 More Information

McReynolds, Jayme R; Vranjkovic, Oliver; Thao, Malia; Baker, David A; Makky, Khadijah; Lim, Yiwei; Mantsch, John R (2014. ) Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice.Psychopharmacology, , 231 (20 ) ,3953-63 More Information

McReynolds, Jayme R; Holloway-Erickson, Crystal M; Parmar, Tulja U; McIntyre, Christa K (2014. ) Corticosterone-induced enhancement of memory and synaptic Arc protein in the medial prefrontal cortex.Neurobiology of learning and memory, , 112 ,148-57 More Information

Mantsch, John R; Vranjkovic, Oliver; Twining, Robert C; Gasser, Paul J; McReynolds, Jayme R; Blacktop, Jordan M (2014. ) Neurobiological mechanisms that contribute to stress-related cocaine use.Neuropharmacology, , 76 Pt B ,383-94 More Information

McReynolds, Jayme R; Peña, David F; Blacktop, Jordan M; Mantsch, John R (2014. ) Neurobiological mechanisms underlying relapse to cocaine use: contributions of CRF and noradrenergic systems and regulation by glucocorticoids.Stress (Amsterdam, Netherlands), , 17 (1 ) ,22-38 More Information

Graf, Evan N; Wheeler, Robert A; Baker, David A; Ebben, Amanda L; Hill, Jonathan E; McReynolds, Jayme R; Robble, Mykel A; Vranjkovic, Oliver; Wheeler, Daniel S; Mantsch, John R; Gasser, Paul J (2013. ) Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 33 (29 ) ,11800-10 More Information

Holloway-Erickson, Crystal M; McReynolds, Jayme R; McIntyre, Christa K (2012. ) Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKII? protein expression in the rostral anterior cingulate cortex.Frontiers in behavioral neuroscience, , 6 ,17 More Information

McReynolds, Jayme R; McIntyre, Christa K (2012. ) Emotional modulation of the synapse.Reviews in the neurosciences, , 23 (5-6 ) ,449-61 More Information

McReynolds, Jayme R; Donowho, Kyle; Abdi, Amin; McGaugh, James L; Roozendaal, Benno; McIntyre, Christa K (2010. ) Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.Neurobiology of learning and memory, , 93 (3 ) ,312-21 More Information

Roozendaal, Benno; McReynolds, Jayme R; Van der Zee, Eddy A; Lee, Sangkwan; McGaugh, James L; McIntyre, Christa K (2009. ) Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 29 (45 ) ,14299-308 More Information

Alkire, Michael T; Gruver, Robin; Miller, Jason; McReynolds, Jayme R; Hahn, Emily L; Cahill, Larry (2008. ) Neuroimaging analysis of an anesthetic gas that blocks human emotional memory.Proceedings of the National Academy of Sciences of the United States of America, , 105 (5 ) ,1722-7 More Information

Alkire, Michael T; McReynolds, Jayme R; Hahn, Emily L; Trivedi, Akash N (2007. ) Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat.Anesthesiology, , 107 (2 ) ,264-72 More Information

Alkire, Michael T; Nathan, Sheila V; McReynolds, Jayme R (2005. ) Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats.Anesthesiology, , 103 (6 ) ,1167-73 More Information

Nathan, Sheila V; Griffith, Qyana K; McReynolds, Jayme R; Hahn, Emily L; Roozendaal, Benno (2004. ) Basolateral amygdala interacts with other brain regions in regulating glucocorticoid effects on different memory functions.Annals of the New York Academy of Sciences, , 1032 ,179-82 More Information

Roozendaal, Benno; McReynolds, Jayme R; McGaugh, James L (2004. ) The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 24 (6 ) ,1385-92 More Information

Spring, Mitchell G; Caccamise, Aaron; Panther, Elizabeth A; Windsor, Bethany M; Soni, Karan R; McReynolds, Jayme R; Wheeler, Daniel S; Mantsch, John R; Wheeler, Robert A (2021. ) Chronic Stress Prevents Cortico-Accumbens Cue Encoding and Alters Conditioned Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 41 (11 ) ,2428-2436 More Information

Manvich, Daniel F; Loweth, Jessica A; Lynch, Wendy J; McReynolds, Jayme R (2023. ) Editorial: Sex differences in the neurobiology of drug relapse vulnerability.Frontiers in behavioral neuroscience, , 17 ,1289459 More Information

McReynolds, Jayme R; Wolf, Colten P; Starck, Dylan M; Mathy, Jacob C; Schaps, Rebecca; Krause, Leslie A; Hillard, Cecilia J; Mantsch, John R (2023. ) Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 48 (8 ) ,1121-1132 More Information

Gaulden, Andrew D; Tepe, Erin A; Sia, Eleni; Rollins, Sierra S; McReynolds, Jayme R (2023. ) Repeated footshock stress induces an escalation of cocaine self-administration in male and female rats: Role of the cannabinoid receptor 1.bioRxiv : the preprint server for biology, , More Information

Gaulden, Andrew D; McReynolds, Jayme R (2022. ) A rock in the toll road: IRAK4 inhibition of TLR4-MyD88 signaling as potential treatment for addiction.Brain, behavior, and immunity, , 104 ,74-75 More Information

Research - Reading Campus
2120 Galbraith Rd
Cincinnati  Ohio, 45237
Phone: 513-558-6893
Fax: 513-297-0966
jayme.mcreynolds@uc.edu