Robert T Means Jr , MD

MD: Vanderbilt University Nashville TN, 1983

BA (magna cum laude): Rice University Houston TX, 1979 (Biochemistry)

Internal Medicine Residency: Baylor College of Medicine Houston TX, 1986

Hematology Fellowship: Vanderbilt University Nashville TN, 1988

American Board of Internal Medicine (Hematology) (Certification Date: 11-01-1988 )

Hematology

Hematology and Oncology

Sickle Cell Anemia

Cancer

Hematology

Peer Reviewed Publications

Benson, Ashley E; Lo, Jamie O; Achebe, Maureen O; Aslan, Jorgeane S; Auerbach, Michael; Bannow, Bethany T Samuelson; Boller, Marie J; Deloughery, Thomas G; Dingman, Jacquelin; Van Doren, Layla; Dy, Geolani W; Ford, Patricia A; Freed, Jason A; Georgieff, Michael K; Haley, Kristina M; Han, Chloe I; Lewkowitz, Adam K; Martens, Kylee L; Means, Robert T; Nemeth, Elizabeta; Olson, Sven R; Powers, Jacquelyn M; Prewitt, Kristin C; Richards, Toby; Rockey, Don C; Roeland, Eric J; Ryan, Kimberly S; Al-Samkari, Hanny; Sholzberg, Michelle; Tuuli, Methodius G; Weyand, Angela C; Zeller, Michelle P; Totten, Annette M; Ivlev, Ilya; Shatzel, Joseph J (2025. ) Management of iron deficiency in children, adults, and pregnant individuals: evidence-based and expert consensus recommendations.The Lancet. Haematology, , 12 (5 ) ,e376-e388 More Information

Means, Robert T; Bi, Caixia; Wong, Edward C C; Bare, Lance A; McPhaul, Michael J (2024. ) Ferritin reference intervals in a population of working-age adults without anemia.American journal of hematology, , 99 (10 ) ,2047-2049 More Information

Means, Robert T (2024. ) New molecular approaches to "the first molecular disease".Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 72 (6 ) ,495-496 More Information

Means, Robert T (2023. ) Pure red cell aplasia: The second hundred years.The American journal of the medical sciences, , 366 (3 ) ,160-166 More Information

Means, Robert T (2023. ) Ineffective erythropoiesis and osteoporosis in thalassemia: Mechanistic insights?.The American journal of the medical sciences, , 366 (2 ) ,85-86 More Information

Al-Samkari, Hanny; Glaspy, John A; Means, Robert T; Chertow, Glenn M; Auerbach, Michael (2022. ) Risks for Anaphylaxis With Intravenous Iron Formulations.Annals of internal medicine, , 175 (11 ) ,W143 More Information

Holt, Hannah D; Holt, Matthew F; Means, Robert T (2022. ) Concurrent pseudothrombocytopenia and immune thrombocytopenia.The American journal of the medical sciences, , 364 (3 ) ,e31-e32 More Information

Means, Robert T (2022. ) New agents for sickle cell disease: patient perceptions of benefit in the real world.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 70 (5 ) ,1210-1211 More Information

Means, Robert T (2022. ) Hepcidin, iron, and COVID-19: is there an erythroid connection?.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 70 (4 ) ,861-862 More Information

Means, Robert T (2022. ) Yet another amyloidosis.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 70 (2 ) ,347 More Information

Means, Robert T (2022. ) Update on pure red cell aplasia: etiology, diagnosis, and treatment. Clinical advances in hematology & oncology : H&O, , 20 (1 ) ,18-21

Fatima, Zainab; Reece, Blair R A; Moore, J Suzanne; Means, Robert T (2022. ) Autoimmune Hemolytic Anemia After mRNA COVID Vaccine.Journal of investigative medicine high impact case reports, , 10 ,23247096211073258 More Information

Means, Robert T (2020. ) Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters.Nutrients, , 12 (2 ) , More Information

Means, Robert T (2020. ) Lymphoma classification: morphology to molecular.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 68 (2 ) ,319-320 More Information

McKenzie, Stacey W; Means, Robert T (2019. ) Blood Cultures and Culture Change.The American journal of the medical sciences, , 358 (3 ) ,171-172 More Information

Means, Robert T (2016. ) Pure red cell aplasia.Hematology. American Society of Hematology. Education Program, , 2016 (1 ) ,51-56 More Information

Means, Robert T (2016. ) Pure red cell aplasia.Blood, , 128 (21 ) ,2504-2509 More Information

Means, Robert T (2016. ) Desiderata: Founders' Medal Award Acceptance.The American journal of the medical sciences, , 352 (1 ) ,9-10 More Information

Means, Robert T (2016. ) The Greatest Hematologist in the World.The American journal of the medical sciences, , 351 (3 ) ,323-4 More Information

Means, Robert T (2015. ) ACP Journal Club. Review: I.v. iron does not increase serious adverse events compared with other forms of iron.Annals of internal medicine, , 162 (10 ) ,JC8 More Information

Means, Robert T (2015. ) Hepcidin in differential diagnosis: ready for the clinic?.European journal of haematology, , 94 (1 ) ,2-3 More Information

Means, Robert T (2013. ) Iron metabolism: bedside to bench and back.The American journal of the medical sciences, , 346 (5 ) ,402 More Information

Means, Robert T (2013. ) Anemia of inflammation: clinical insights from mechanisms. [Rinsho ketsueki] The Japanese journal of clinical hematology, , 54 (10 ) ,1596-602

Means, Robert T (2013. ) Iron deficiency anemia.Hematology (Amsterdam, Netherlands), , 18 (5 ) ,305-6 More Information

Means, Robert T (2013. ) Continuing adventures.The American journal of the medical sciences, , 346 (1 ) ,1-2 More Information

Christopher, K L; Wiggins, A T; Van Meter, E M; Means, R T; Hayslip, J W; Roach, J P (2013. ) Differences in vitamin D nutritional status between newly diagnosed cancer patients from rural or urban settings in Kentucky.Nutrition and cancer, , 65 (5 ) ,653-8 More Information

Means, Robert T (2013. ) Hepcidin and iron regulation in health and disease.The American journal of the medical sciences, , 345 (1 ) ,57-60 More Information

Wilson, Bethany; Means, Robert T (2011. ) Acquired factor VIII inhibitor as initial manifestation of collagen vascular disease: response to combination immunosuppression as first-line therapy.The American journal of the medical sciences, , 342 (1 ) ,70-2 More Information

Means, Robert T (2011. ) Free and easy? Red cell distribution width (RDW) and prognosis in cardiac disease.Journal of cardiac failure, , 17 (4 ) ,299-300 More Information

Means, Robert T (2011. ) It all started in New Orleans: Wintrobe, the hematocrit and the definition of normal.The American journal of the medical sciences, , 341 (1 ) ,64-5 More Information

Means, Robert T (2010. ) JAK2 V617F and the evolving paradigm of polycythemia vera.The Korean journal of hematology, , 45 (2 ) ,90-4 More Information

Means, Robert T; Moliterno, David J; Allison, G Roxanne; Perman, Jay A; Lofgren, Richard P; Karpf, Michael; Debeer, Frederick C (2010. ) The evolution of a Department of Internal Medicine under an integrated clinical enterprise model: the University of Kentucky experience.Academic medicine : journal of the Association of American Medical Colleges, , 85 (3 ) ,531-7 More Information

Means, Robert T (2009. ) Higher red blood cell distribution width was associated with increased risk of mortality in adults > or =45 years of age.Evidence-based medicine, , 14 (5 ) ,151 More Information

Means, Robert T (2009. ) Ironing out complementary medicine.Blood, , 113 (2 ) ,270-1 More Information

Dallalio, Gail; Means, Robert T (2008. ) Placental growth factor attenuates suppression of erythroid colony formation by interferon.Translational research : the journal of laboratory and clinical medicine, , 152 (5 ) ,233-8 More Information

Means, Robert T (2008. ) JAK2 V617F mutation testing in polycythemia vera: use and impact in an academic practice.The American journal of the medical sciences, , 336 (4 ) ,327-9 More Information

Means, Robert T (2008. ) Perspective: Osler's 1903 paper on polycythemia vera.The American journal of the medical sciences, , 335 (6 ) ,418-9 More Information

Dallalio, Gail; Brunson, Chris Y; Means, Robert T (2007. ) Cytokine concentrations in bone marrow of stable sickle cell anemia patients.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 55 (2 ) ,69-74 More Information

Dallalio, Gail; Law, Erin; Means, Robert T (2006. ) Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations.Blood, , 107 (7 ) ,2702-4 More Information

Masimasi, Nziavake; Means, Robert T (2005. ) Elevated troponin levels associated with hemolysis.The American journal of the medical sciences, , 330 (4 ) ,201-3 More Information

Means, Robert T (2004. ) Hepcidin and anaemia.Blood reviews, , 18 (4 ) ,219-25 More Information

Means, Robert T (2004. ) Hepcidin and cytokines in anaemia.Hematology (Amsterdam, Netherlands), , 9 (5-6 ) ,357-62 More Information

Dallalio, Gail; Fleury, Thomas; Means, Robert T (2003. ) Serum hepcidin in clinical specimens.British journal of haematology, , 122 (6 ) ,996-1000 More Information

Dallalio, Gail; Means, Robert T (2003. ) Effects of oxidative stress on human erythroid colony formation: Modulation by gamma-interferon.The Journal of laboratory and clinical medicine, , 141 (6 ) ,395-400 More Information

Means, Robert T (2003. ) Recent developments in the anemia of chronic disease. Current hematology reports, , 2 (2 ) ,116-21

Van Laer, A; Dallalio, Gail; McKenzie, Stacey W; Means, Robert T (2002. ) Thioredoxin and protein nitrotyrosine in bone marrow supernatant from patients with human immunodeficiency virus infection. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 50 (1 ) ,10-8

Pollak, V E; Lorch, J A; Means, R T (2001. ) Unanticipated favorable effects of correcting iron deficiency in chronic hemodialysis patients.Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 49 (2 ) ,173-83 More Information

Means, R T (2000. ) The anaemia of infection.Bailliere's best practice & research. Clinical haematology, , 13 (2 ) ,151-62 More Information

Dallalio, G; North, M; McKenzie, S W; Means, R T (1999. ) Cytokine and cytokine receptor concentrations in bone marrow supernatant from patients with HIV: correlation with hematologic parameters. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 47 (9 ) ,477-83

Mendenhall, C L; Finkelman, F; Means, R T; Sherman, K E; Nguyen, V T; Grossman, C E; Morris, S C; Rouster, S; Roselle, G A (1999. ) Cytokine response to BCG infection in alcohol-fed mice.Alcohol (Fayetteville, N.Y.), , 19 (1 ) ,57-63 More Information

Means, R T (1999. ) Advances in the anemia of chronic disease. International journal of hematology, , 70 (1 ) ,7-12

Dallalio, G; North, M; Worden, B D; Means, R T (1999. ) Inhibition of human erythroid colony formation by ceramide.Experimental hematology, , 27 (7 ) ,1133-8 More Information

Means, R T; Allen, J; Sears, D A; Schuster, S J (1999. ) Serum soluble transferrin receptor and the prediction of marrow aspirate iron results in a heterogeneous group of patients.Clinical and laboratory haematology, , 21 (3 ) ,161-7 More Information

Means, R T (1999. ) Commentary: an anemia of chronic disease, after all? .Journal of investigative medicine : the official publication of the American Federation for Clinical Research, , 47 (5 ) ,203

Means, R T (1999. ) Neocytolysis: from outer space to the dialysis unit.American journal of kidney diseases : the official journal of the National Kidney Foundation, , 33 (1 ) ,140-1 More Information

Wani, M A; Means, R T; Lingrel, J B (1998. ) Loss of LKLF function results in embryonic lethality in mice.Transgenic research, , 7 (4 ) ,229-38 More Information

Allen, J; Backstrom, K R; Cooper, J A; Cooper, M C; Detwiler, T C; Essex, D W; Fritz, R P; Means, R T; Meier, P B; Pearlman, S R; Roitman-Johnson, B; Seligman, P A (1998. ) Measurement of soluble transferrin receptor in serum of healthy adults. Clinical chemistry, , 44 (1 ) ,35-9

Means, R T (1997. ) Cytokines and anaemia in human immunodeficiency virus infection. Cytokines, cellular & molecular therapy, , 3 (3 ) ,179-86

North, M; Dallalio, G; Donath, A S; Melink, R; Means, R T (1997. ) Serum transferrin receptor levels in patients undergoing evaluation of iron stores: correlation with other parameters and observed versus predicted results.Clinical and laboratory haematology, , 19 (2 ) ,93-7 More Information

McKenzie, S W; Means, R T (1997. ) Extreme hyperferritinemia in patients infected with human immunodeficiency virus is not a highly specific marker for disseminated histoplasmosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 24 (3 ) ,519-20 More Information

Dallalio, G; North, M; Means, R T (1996. ) Inhibition of marrow CFU-E colony formation from human immunodeficiency virus-infected patients by beta- and gamma-interferon.American journal of hematology, , 53 (2 ) ,118-20 More Information

McKenzie, S W; Dallalio, G; North, M; Frame, P; Means, R T (1996. ) Serum chemokine levels in patients with non-progressing HIV infection.AIDS (London, England), , 10 (9 ) ,F29-33 More Information

Dai, W; Pan, H Q; Ouyang, B; Greenberg, J M; Means, R T; Li, B; Cardie, J (1996. ) Expression of receptor protein tyrosine kinase tif is regulated during leukemia cell differentiation. Leukemia, , 10 (6 ) ,978-83

Means, R T; Mendenhall, C L; Worden, B D; Moritz, T E; Chedid, A (1996. ) Erythropoietin and cytokine levels in the anemia of severe alcoholic liver disease.Alcoholism, clinical and experimental research, , 20 (2 ) ,355-8 More Information

Means, R T; Krantz, S B (1996. ) Inhibition of human erythroid colony-forming units by interferons alpha and beta: differing mechanisms despite shared receptor. Experimental hematology, , 24 (2 ) ,204-8

Lee, M H; Means, R T (1995. ) Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance.The American journal of medicine, , 98 (6 ) ,566-71 More Information

Means, R T (1995. ) Erythropoietin in the treatment of anemia in chronic infectious, inflammatory, and malignant diseases.Current opinion in hematology, , 2 (3 ) ,210-3 More Information

Means, R T (1995. ) Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia.Stem cells (Dayton, Ohio), , 13 (1 ) ,32-7 More Information

Stein, R S; Means, R T; Krantz, S B; Flexner, J M; Greer, J P (1994. ) Treatment of aplastic anemia with an investigational antilymphocyte serum prepared in rabbits.The American journal of the medical sciences, , 308 (6 ) ,338-43 More Information

Means, R T (1994. ) Clinical application of recombinant erythropoietin in the anemia of chronic disease. Hematology/oncology clinics of North America, , 8 (5 ) ,933-44

Means, R T; Krantz, S B; Luna, J; Marsters, S A; Ashkenazi, A (1994. ) Inhibition of murine erythroid colony formation in vitro by interferon gamma and correction by interferon receptor immunoadhesin. Blood, , 83 (4 ) ,911-5

Means, R T; Krantz, S B (1993. ) Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon.The Journal of clinical investigation, , 91 (2 ) ,416-9 More Information

Means, R T; Sandidge, D R; Rankin, K M; Robichaux, M R (1992. ) Treatment of phenothiazine-induced agranulocytosis with recombinant granulocyte colony-stimulating factor.American journal of hematology, , 41 (4 ) ,296 More Information

Means, R T; Krantz, S B (1992. ) Progress in understanding the pathogenesis of the anemia of chronic disease. Blood, , 80 (7 ) ,1639-47

Dai, C H; Krantz, S B; Dessypris, E N; Means, R T; Horn, S T; Gilbert, H S (1992. ) Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood, , 80 (4 ) ,891-9

Means, R T; Dessypris, E N; Krantz, S B (1992. ) Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon.Journal of cellular physiology, , 150 (1 ) ,59-64 More Information

Means, R T; Krantz, S B (1991. ) Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin. Blood, , 78 (10 ) ,2564-7

Means, R T; Dessypris, E N; Krantz, S B (1991. ) Treatment of refractory pure red cell aplasia with cyclosporine A: disappearance of IgG inhibitor associated with clinical response.British journal of haematology, , 78 (1 ) ,114-9 More Information

Cotton, E W; Means, R T; Cline, S M; Krantz, S B (1991. ) Quantitation of insulin-like growth factor-I binding to highly purified human erythroid colony-forming units. Experimental hematology, , 19 (4 ) ,278-81

Dai, C H; Krantz, S B; Means, R T; Horn, S T; Gilbert, H S (1991. ) Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3.The Journal of clinical investigation, , 87 (2 ) ,391-6 More Information

Means, R T; Dessypris, E N; Krantz, S B (1990. ) Inhibition of human colony-forming-unit erythroid by tumor necrosis factor requires accessory cells.The Journal of clinical investigation, , 86 (2 ) ,538-41 More Information

Dai, C H; Krantz, S B; Means, R T; Horn, S T; Gilbert, H S (1990. ) Increased sensitivity of polycythemia vera blood burst-forming units-erythroid to interleukin 3. Transactions of the Association of American Physicians, , 103 ,249-57

Means, R T; Krantz, S B; Sawyer, S T; Gilbert, H S (1989. ) Erythropoietin receptors in polycythemia vera.The Journal of clinical investigation, , 84 (4 ) ,1340-4 More Information

Means, R T; Olsen, N J; Krantz, S B; Dessypris, E N; Graber, S E; Stone, W J; O'Neil, V L; Pincus, T (1989. ) Treatment of the anemia of rheumatoid arthritis with recombinant human erythropoietin: clinical and in vitro studies.Arthritis and rheumatism, , 32 (5 ) ,638-42 More Information

Means, R T; McCurley, T L; Flexner, J M; Stein, R S (1988. ) Plasmacytic neoplasm of the gastrointestinal tract in a patient with long-standing monoclonal gammopathy.Southern medical journal, , 81 (10 ) ,1331-2 More Information

Means, R T; Krantz, S B; Dessypris, E N; Lukens, J N; Niblack, G D; Greer, J P; Flexner, J M; Stein, R S (1988. ) Re-treatment of aplastic anemia with antithymocyte globulin or antilymphocyte serum.The American journal of medicine, , 84 (4 ) ,678-82 More Information