Jaroslaw Meller

Jaroslaw Meller

Graduate Program Director and Associate Professor

Kettering Lab Complex

316

COM EH Bio Meller Lab - 0056

Kettering Laboratory Complex
Room 316
Cincinnati, Ohio 45267

Professional Summary

Building upon broad interdisciplinary training in molecular modeling, computational chemistry, and bioinformatics, Dr. Meller has been pursuing research at the intersection of computational genomics and biomedicine. Dr. Meller has a primary appointment in the Department of Environmental Health, University of Cincinnati College of Medicine, and joint/secondary appointments in the Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, and the School of Electrical Engineering and Computing Systems, University of Cincinnati College of Engineering and Applied Sciences. Dr. Meller has published over 70 original research articles with over 2,500 citations and ISI Web of Science H-index of 30. See professional profiles at http://scholar.google.com/citations?user=vQguoK4AAAAJ&hl=en and http://www.researcherid.com/rid/A-1971-2011 .

Dr. Meller and his group have developed a number of successful methods for the prediction of protein structure, protein-protein interactions and functional hot spots in proteins (Adamczak et al., 2004, 2005; Wagner et al., 2005; Porollo and Meller, 2007, 2010; Adamczak et al., 2011; Phatak et al., 2011). Several web servers developed by the group, including Sable, Sppider, Minnou and Polyview have widely been used, with a total of over 900,000 submissions from more than 30,000 users in many countries. For the development of successful prediction, modeling and visualization tools for structural bioinformatics and functional genomics, Dr. Meller received Ohio Cyber-infrastructure Experimental & Application Research Award. Dr. Meller has also been active in the development and applications of methods for knowledge extraction from high dimensional genomic data (Sinha and Meller, 2008; Shinde et al., 2010; Huang et al., 2012).

Benefiting from a strong emphasis on team science at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center, Dr. Meller and his group have also been involved in many collaborative projects with direct medical relevance. Examples of such interdisciplinary efforts include sequencing and annotation of human pathogens, identification of markers associated with disease subtypes in cancer and autoimmunity, modeling of signal transduction pathways in differentiation and development, developing inhibitors of critical protein-protein interactions in autophagy, bone marrow transplants, and pathogen-host interactions.

Dr. Meller has been broadly involved in quantitative and computational training efforts within UC College of Medicine and College of Engineering and Applied Sciences, leading several inter-departmental and inter-collegiate initiatives in this regard. Dr. Meller serves as the Director of the newly created PhD program in Biomedical Informatics at UC, co-director of the Biomedical Informatics Graduate Certificate Program, and has been involved in several informatics and quantitative training efforts at UC College of Medicine, including T32 Advanced Multidisciplinary Training Program for Systems Biology and T32 Gene-Environment Interactions Training Grant. In addition, Dr. Meller is the co-director of the Bioinformatics Core for the Center of Environmental Genetics at the University of Cincinnati. He also serves as the director of Protein Informatics Core at Cincinnati Children’s Hospital Medical Center.

Education

Doctoral Degree, Nicholas Copernicus University 1996 (Computational Chemistry)

Doctoral Degree, Polish Academy of Sciences 2004 (Biomedical Engineering)

Positions and Work Experience

2001 -2005 Assistant Professor, Cincinnati Children's Hospital Medical Center,

2005 -2006 Associate Professor, Cincinnati Children's Hospital Medical Center,

2007 -2012 Associate Professor, University of Cincinnati,

Research and Practice Interests

My research is focused on computational methods in molecular biology and genomics. In short, what we are doing may be classified either as computational biology or bioinformatics, with significant component of pattern recognition and machine learning. We are pursuing research on fundamental problems, such as protein folding process and protein-protein interactions. On a more practical side, we are also interested in developing bioinformatics tools, e.g. for protein structure and function recognition or gene annotation. We are also developing methods for identification of predictive fingerprints of disease states that aim at finding correlation between multiple genomic and clinical attributes with disease states, progression and treatment response. In collaboration with biologists, biochemists and physicians, we are applying standard and our own methods to particular problems at hands.

Research Support

Grant: #CHMC 100139 / R01 AR050688 Investigators:Meller, Jaroslaw 09-01-2006 -08-31-2008 National Institute of Arthritis, Musculoskeletal and Skin Disease Genomic Landscapes in Large Scale Integrated JRA Studies Role:PI $66,191.00 Closed Level:Federal

Grant: #CHMC 102680 / R01 AI055649 Investigators:Meller, Jaroslaw 09-01-2006 -01-01-2010 National Institute of Allergy and Infectious Diseases Norwalk-Like Viruses and their Receptors Role:PI $119,894.00 Closed Level:Federal

Grant: #P30 ES006096-16A1 Investigators:Caruso, Joseph; Deka, Ranjan; Embi, Peter; Greis, Kenneth; Ho, Shuk Mei; Lemasters, Grace; Medvedovic, Mario; Meller, Jaroslaw; Nebert, Daniel; Pinney, Susan; Puga, Alvaro; Rohs, Amy; Woo, Daniel 04-01-2008 -03-31-2013 National Institute of Environmental Health Sciences Environmental Genetics Role:Collaborator $8,028,782.00 Active Level:Federal

Grant: #08-S587-027-01-C1 Investigators:Meller, Jaroslaw 06-30-2008 -05-29-2009 Department of the Air Force Computational Modeling of Resilin and Related Polypeptides Role:PI $48,000.00 Active Level:Federal

Grant: #UTA08-479 / R01 GM067823 Investigators:Meller, Jaroslaw 08-01-2008 -08-31-2011 National Institute of General Medical Sciences Optimizing of Folding and Threading Potentials Role:PI $95,259.00 Closed Level:Federal

Grant: #CMMI 0825710 Investigators:Huang, Hongdao Samuel; Meller, Jaroslaw 09-01-2008 -08-31-2012 National Science Foundation Robust and Efficient Knowledge Discovery with Application in Cancer Foundation Role:Collaborator $374,998.00 Closed Level:Federal

Grant: #106338 / 2 P01 HD013021-31A1 Investigators:Meller, Jaroslaw 08-01-2009 -07-31-2014 National Institute of Child Health and Human Development The Role of Human Milk in Infant Nutrition and Health Role:PI $51,362.00 Active Level:Federal

Grant: #1006619 / 3 U01 AI067150-05S1 Investigators:Meller, Jaroslaw 09-01-2009 -03-31-2011 National Institute of Allergy and Infectious Diseases HLA/KIR Region Genetics in Pediatric Arthritis Role:PI $26,395.00 Closed Level:Federal

Grant: #107121 / R56AI055649 Investigators:Meller, Jaroslaw 09-07-2010 -08-31-2011 National Institute of Allergy and Infectious Diseases Norovirus and Their Receptors Role:PI $29,599.00 Closed Level:Federal

Grant: #SRS 007647 Investigators:Czyzyk-Krzeska, Maria; Meller, Jaroslaw 07-01-2011 -04-30-2015 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Jaroslow Meller Role:Collaborator $34,172.00 Active Level:Federal

Grant: #R01 CA122346 Investigators:Czyzyk-Krzeska, Maria; Meller, Jaroslaw 04-01-2013 -03-31-2018 National Cancer Institute Molecular Mechanisms in Renal Cancer Role:Collaborator $291,425.00 Active Level:Federal

Grant: #P30ES006096 Investigators:Caruso, Joseph; Chen, Aimin; Deka, Ranjan; Greis, Kenneth; Haynes, Erin; Ho, Shuk Mei; Lemasters, Grace; Leung, Yuet Kin; Medvedovic, Mario; Meller, Jaroslaw; Meloncon, Lisa; Pinney, Susan; Porollo, Alexey; Puga, Alvaro; Thomas, Michael; Woo, Daniel; Yadav, Jagjit; Yancey, Elissa 04-01-2013 -03-31-2018 National Institute of Environmental Health Sciences Environmental Genetics Role:Collaborator $1,743,768.00 Active Level:Federal

Grant: #T32 GM105526 Investigators:Meller, Jaroslaw; Montrose, Marshall 07-01-2013 -06-30-2016 National Institute of General Medical Sciences Advanced Multidisciplinary Training Program for Systems Biology Role:Collaborator $86,681.00 Active Level:Federal

Grant: #R21AI097936 Investigators:Meller, Jaroslaw; Porollo, Alexey 08-06-2013 -07-31-2015 National Institute of Allergy and Infectious Diseases Norovirus Capsid: A Novel Drug Target Role:PI $197,749.00 Awarded Level:Federal

Grant: #W81XWH-14-1-0347 / CA130028 Investigators:Czyzyk-Krzeska, Maria; Medvedovic, Mario; Meller, Jaroslaw 09-30-2014 -09-29-2016 Department of the Army Medical Research Acquisition Activity CA130028-Effects of Tobacco Smoke (TS) on growth of clear cell renal cell carcinoma (ccRCC) Role:Collaborator $474,562.00 Awarded Level:Federal

Grant: #0255-7855-4609 / U54 HL127624 Investigators:Medvedovic, Mario; Meller, Jaroslaw; Sivaganesan, Siva 09-29-2014 -04-30-2019 National Heart, Lung and Blood Institute Data Coordination and Integration Center for LINCS-BD2K Role:Collaborator $609,822.00 Active Level:Federal

Grant: #R21ES024807 Investigators:Bernstein, David; Grinshpun, Sergey; Meller, Jaroslaw; Reponen, Tiina 09-30-2015 -09-29-2017 National Institute of Environmental Health Sciences Traffic-related air pollutants and respiratory tract microbiome in children Role:Collaborator $217,917.00 Awarded Level:Federal

Grant: #R21MH107916 Investigators:Funk, Adam; Greis, Kenneth; McCullumsmith, Robert; Meller, Jaroslaw 05-13-2016 -04-30-2018 National Institute of Mental Health Proteomic analysis of the postsynaptic density-95 interactome in schizophrenia Role:Collaborator $237,000.00 Awarded Level:Federal

Grant: #R01MH107487 Investigators:McCullumsmith, Robert; Meller, Jaroslaw 07-15-2016 -04-30-2021 National Institute of Mental Health Cell-specific analysis of sub-kinomes in schizophrenia Role:Collaborator $395,000.00 Active Level:Federal

Grant: #137687 / R01HD089458 Investigators:Meller, Jaroslaw 01-01-2017 -08-31-2017 National Institute of Child Health and Human Development Pharmacogenetics of Opioids, Reducing Persistent Postoperative Pain and Opioid Dependence Role:PI $12,008.00 Awarded Level:Federal

Grant: #IN4682013UC / R01HD089458 Investigators:Meller, Jaroslaw 09-01-2017 -08-31-2018 National Institute of Child Health and Human Development Pharmacogenetics of Oxycodone, Personalized Care and Persistent Surgical Pain Role:PI $9,474.00 Active Level:Federal

Grant: #2003-UC-15 BRTT-01-A0-S0-E0 Investigators:Brackenbury, Robert; Meller, Jaroslaw 07-01-2002 -06-30-2019 Ohio Department of Higher Education Functional Genomics in Biomedical Research Role:PI $175,000.00 Active Level:State of Ohio

Grant: #F-2019-39 / R01MH107487 Investigators:Meller, Jaroslaw 01-01-2019 -04-30-2021 National Institutes of Health Cell-specific analysis of sub-kinomes in schizophrenia Role:PI $36,701.00 Awarded Level:Federal

Grant: #306131 / R01DK091566 Investigators:Meller, Jaroslaw 01-01-2019 -12-31-2022 National Inst of Diabetes and Digestive and Kidney Disease Genetic basis of virus induced Biliary Atresia Role:PI $8,526.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Adamczak R, Porollo A, Meller J. (09-2004. )Accurate prediction of solvent accessibility using neural networks-based regression. Proteins., ,56 (4 ),753

Adamczak R, Porollo A, Meller J. (05-2005. )Combining prediction of secondary structure and solvent accessibility in proteins. Proteins., ,59 (3 ),467

Porollo A, Meller J. (02-2007. )Prediction-based fingerprints of protein-protein interactions .Proteins., ,66 (3 ),630

Sinha AU, Meller J. (03-2007. )Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms. BMC Bioinformatics., ,8 (82 ),

Cao B, Porollo A, Adamczak R, Jarrell M, Meller J. (02-2006. )Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics., ,22 (3 ),303

Post Graduate Training and Education

1996-1997 postdoctoral fellow, Hebrew University, ,Israel

1997-1998 JSPS fellow, Kyoto University, ,Japan

1999-2001 postdoctoral fellow, Cornell University, ,USA

Keywords

bioinformatics, biomedical informatics, computational biology, prediction methods, predictive fingerprints of disease states, protein structure and function, membrane proteins, gene finding and annotation, bioinformatics and computational biology courses

Contact Information

Academic - Kettering Laboratory Complex
Room 316
Ohio, 45267
Phone: 513-558-1958
jaroslaw.meller@uc.edu