Marian L Miller

3 decades of applying principles of morphometry and sterology in histology and electron microscopy on scores of tissues related to processes of carcinogenesis, toxic responses, and on genetically engineered mice.

1964-65 Pasadena Foundation for Medical Research, Pasadena California
1965-67 California Institute of Technology, Pasadena, CA
1971-73 Post Doctoral Research (Microscopy), Dept. of Environmental Health, University of Cincinnati
1973-75 Assistant Professor of Research Pediatrics, Children’s Hospital Research Foundation
1975-80 Assistant Professor of Research Pediatrics, Children’s Hospital Research Foundation
1980-88 Adjunct Assistant Professor, Dept. Environ. Health, College of Med., Univ. of Cinti
1989-94 Adjunct Associate Professor
1995-2007 Research Associate Professor, Dept. Environ. Health
2007-2008 Adjunct Research Asociate Professor, Dept. Environ. Health

Bachelor's Degree: Westmont College Santa Barbara, CA , 1961

Doctoral Degree: University of Toronto Toronto, Ontario , 1964

Doctoral Degree: University of Cincinnati, College of Medicine, Dept. Anatomy 1971 (Quantitative Microscopy)

Postdoctoral Fellowship: University Of Cincinnati Cincinnati, OH, 1973 (Environmental Health)

2008 - Associate Professor Emerita,

Grant: #U01 ES019480 Investigators:Belcher, Scott; Ben-Jonathan, Nira; Ho, Shuk Mei; Levin, Linda; Medvedovic, Mario; Miller, Marian; Stambrook, Peter; Tso, Patrick P.W. 09-22-2010 -05-31-2015 National Institute of Environmental Health Sciences Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk Role:Collaborator $1,790,100.00 Active Level:Federal

Peer Reviewed Publications

Miller, Marian L; Porollo, Aleksey; Wert, Susan (2018. ) Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species.Anatomical record (Hoboken, N.J. : 2007), , More Information

Mortazavi, Smj; Bevelacqua, Joseph John; Corrice, Leslie; Dobrzy?ski, Ludwik; Feinendegen, Ludwig E; Miller, Mark L; Sacks, Bill; Ulsh, Brant; Pennington, Charles W; Welsh, James; Doss, Mohan (2017. ) Comment on "Chromosomal Aberrations in Large Japanese Field Mice (Apodemus speciosus) Captured Near Fukushima Dai-ichi Nuclear Power Plant".Environmental science & technology, , 51 (14 ) ,8196-8197 More Information

Gálvez-Peralta, Marina; He, Lei; Jorge-Nebert, Lucia F; Wang, Bin; Miller, Marian L; Eppert, Bryan L; Afton, Scott; Nebert, Daniel W (2012. ) ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.PloS one, , 7 (5 ) ,e36055 More Information

Zhang, Yu; Johansson, Elisabet; Miller, Marian L; Jänicke, Reiner U; Ferguson, Donald J; Plas, David; Meller, Jarek; Anderson, Marshall W (2011. ) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.PloS one, , 6 (9 ) ,e25284 More Information

Curran, Christine P; Vorhees, Charles V; Williams, Michael T; Genter, Mary Beth; Miller, Marian L; Nebert, Daniel W (2011. ) In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.Toxicological sciences : an official journal of the Society of Toxicology, , 119 (1 ) ,189-208 More Information

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Orr-Asman, Melissa A; Miller, Marian L; Lertkowit, Nantaporn; Varro, Andrea; Hollande, Frederic; Zavros, Yana (2010. ) Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.Gastroenterology, , 138 (2 ) ,550-61, 561.e1-8 More Information

Prasad, Vikram; Bodi, Ilona; Meyer, Jamie W; Wang, Yigang; Ashraf, Muhammad; Engle, Sandra J; Doetschman, Thomas; Sisco, Karena; Nieman, Michelle L; Miller, Marian L; Lorenz, John N; Shull, Gary E (2008. ) Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.The Journal of biological chemistry, , 283 (46 ) ,31303-14 More Information

Okunade, Gbolahan W; Miller, Marian L; Azhar, Mohamad; Andringa, Anastasia; Sanford, L Philip; Doetschman, Thomas; Prasad, Vikram; Shull, Gary E (2007. ) Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.The Journal of biological chemistry, , 282 (36 ) ,26517-27 More Information

Gawenis, Lara R; Bradford, Emily M; Prasad, Vikram; Lorenz, John N; Simpson, Janet E; Clarke, Lane L; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E (2007. ) Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter.The Journal of biological chemistry, , 282 (12 ) ,9042-52 More Information

Dragin, Nadine; Dalton, Timothy P; Miller, Marian L; Shertzer, Howard G; Nebert, Daniel W (2006. ) For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.The Journal of biological chemistry, , 281 (27 ) ,18591-600 More Information

Prasad, Vikram; Boivin, Gregory P; Miller, Marian L; Liu, Lynne H; Erwin, Christopher R; Warner, Brad W; Shull, Gary E (2005. ) Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility.Cancer research, , 65 (19 ) ,8655-61 More Information

Gawenis, Lara R; Greeb, Jeannette M; Prasad, Vikram; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Andringa, Anastasia; Miller, Marian L; Shull, Gary E (2005. ) Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger.The Journal of biological chemistry, , 280 (13 ) ,12781-9 More Information

Okunade, Gbolahan W; Miller, Marian L; Pyne, Gail J; Sutliff, Roy L; O'Connor, Kyle T; Neumann, Jonathan C; Andringa, Anastasia; Miller, Daniel A; Prasad, Vikram; Doetschman, Thomas; Paul, Richard J; Shull, Gary E (2004. ) Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.The Journal of biological chemistry, , 279 (32 ) ,33742-50 More Information

Gawenis, Lara R; Ledoussal, Clara; Judd, Louise M; Prasad, Vikram; Alper, Seth L; Stuart-Tilley, Alan; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E (2004. ) Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric.The Journal of biological chemistry, , 279 (29 ) ,30531-9 More Information

Miller, Marian L; Andringa, Anastasia; Turner, Lloyd T; Dalton, Timothy P; Derkenne, Sandrine; Nebert, Daniel W (2003. ) Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth.Microscopy research and technique, , 60 (5 ) ,528-36 More Information

Woo, Alison L; Gildea, Lucy A; Tack, Leslie M; Miller, Marian L; Spicer, Zachary; Millhorn, David E; Finkelman, Fred D; Hassett, Daniel J; Shull, Gary E (2002. ) In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea.The Journal of biological chemistry, , 277 (50 ) ,49036-46 More Information

Lorenz, John N; Baird, Nancy R; Judd, Louise M; Noonan, William T; Andringa, Anastasia; Doetschman, Thomas; Manning, Patrice A; Liu, Lynne H; Miller, Marian L; Shull, Gary E (2002. ) Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.The Journal of biological chemistry, , 277 (40 ) ,37871-80 More Information

Ledoussal, C; Woo, A L; Miller, M L; Shull, G E (2001. ) Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice.American journal of physiology. Gastrointestinal and liver physiology, , 281 (6 ) ,G1385-96 More Information

Spicer, Z; Miller, M L; Andringa, A; Riddle, T M; Duffy, J J; Doetschman, T; Shull, G E (2000. ) Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia.The Journal of biological chemistry, , 275 (28 ) ,21555-65 More Information

Dalton, T P; Miller, M L; Wu, X; Menon, A; Cianciolo, E; McKinnon, R A; Smith, P W; Robinson, L J; Nebert, D W (2000. ) Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis. Pharmacogenetics, , 10 (2 ) ,141-51

Shull, G E; Miller, M L; Schultheis, P J (2000. ) Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract.American journal of physiology. Gastrointestinal and liver physiology, , 278 (2 ) ,G185-90 More Information

Miller, M L; Vasunia, K; Talaska, G; Andringa, A; de Boer, J; Dixon, K (2000. ) The tumor promoter TPA enhances benzo[a]pyrene and benzo[a]pyrene diolepoxide mutagenesis in Big Blue mouse skin. Environmental and molecular mutagenesis, , 35 (4 ) ,319-27

Flagella, M; Clarke, L L; Miller, M L; Erway, L C; Giannella, R A; Andringa, A; Gawenis, L R; Kramer, J; Duffy, J J; Doetschman, T; Lorenz, J N; Yamoah, E N; Cardell, E L; Shull, G E (1999. ) Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. The Journal of biological chemistry, , 274 (38 ) ,26946-55

Sutliff, R L; Weber, C S; Qian, J; Miller, M L; Clemens, T L; Paul, R J (1999. ) Vasorelaxant properties of parathyroid hormone-related protein in the mouse: evidence for endothelium involvement independent of nitric oxide formation.Endocrinology, , 140 (5 ) ,2077-83 More Information

Bell, S M; Schreiner, C M; Schultheis, P J; Miller, M L; Evans, R L; Vorhees, C V; Shull, G E; Scott, W J (1999. ) Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. The American journal of physiology, , 276 (4 Pt 1 ) ,C788-95

Schultheis, P J; Lorenz, J N; Meneton, P; Nieman, M L; Riddle, T M; Flagella, M; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E (1998. ) Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. The Journal of biological chemistry, , 273 (44 ) ,29150-5

Kozel, P J; Friedman, R A; Erway, L C; Yamoah, E N; Liu, L H; Riddle, T; Duffy, J J; Doetschman, T; Miller, M L; Cardell, E L; Shull, G E (1998. ) Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. The Journal of biological chemistry, , 273 (30 ) ,18693-6

Schultheis, P J; Clarke, L L; Meneton, P; Miller, M L; Soleimani, M; Gawenis, L R; Riddle, T M; Duffy, J J; Doetschman, T; Wang, T; Giebisch, G; Aronson, P S; Lorenz, J N; Shull, G E (1998. ) Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger.Nature genetics, , 19 (3 ) ,282-5 More Information

Schultheis, P J; Clarke, L L; Meneton, P; Harline, M; Boivin, G P; Stemmermann, G; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E (1998. ) Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.The Journal of clinical investigation, , 101 (6 ) ,1243-53 More Information

Liu, L H; Paul, R J; Sutliff, R L; Miller, M L; Lorenz, J N; Pun, R Y; Duffy, J J; Doetschman, T; Kimura, Y; MacLennan, D H; Hoying, J B; Shull, G E (1997. ) Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. The Journal of biological chemistry, , 272 (48 ) ,30538-45

Miller, M L; Andringa, A; Albert, R E; Cody, T (1996. ) Colcemid alters S phase and other parameters in skin during chronic exposure to benzo(a)pyrene.Microscopy research and technique, , 35 (4 ) ,307-13 More Information

Albert, R E; Miller, M L; Cody, T E; Talaska, G; Underwood, P; Andringa, A (1996. ) Epidermal cytokinetics, DNA adducts, and dermal inflammation in the mouse skin in response to repeated benzo[a]pyrene exposures.Toxicology and applied pharmacology, , 136 (1 ) ,67-74 More Information

Evans, J E; Miller, M L; Andringa, A; Hastings, L (1995. ) Behavioral, histological, and neurochemical effects of nickel (II) on the rat olfactory system.Toxicology and applied pharmacology, , 130 (2 ) ,209-20 More Information

Swiecichowski, A L; Long, K J; Miller, M L; Leikauf, G D (1993. ) Formaldehyde-induced airway hyperreactivity in vivo and ex vivo in guinea pigs.Environmental research, , 61 (2 ) ,185-99 More Information

Cibulas, W; Brooks, S M; Murlas, C G; Miller, M L; McKay, R T (1988. ) Toluene diisocyanate-induced airway hyperreactivity in guinea pigs depleted of granulocytes.Journal of applied physiology (Bethesda, Md. : 1985), , 64 (5 ) ,1773-8 More Information

Schumann, B L; Cody, T E; Miller, M L; Leikauf, G D (1988. ) Isolation, characterization, and long-term culture of fetal bovine tracheal epithelial cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association, , 24 (3 ) ,211-6