Marian L Miller

3 decades of applying principles of morphometry and sterology in histology and electron microscopy on scores of tissues related to processes of carcinogenesis, toxic responses, and on genetically engineered mice.

1964-65 Pasadena Foundation for Medical Research, Pasadena California
1965-67 California Institute of Technology, Pasadena, CA
1971-73 Post Doctoral Research (Microscopy), Dept. of Environmental Health, University of Cincinnati
1973-75 Assistant Professor of Research Pediatrics, Children’s Hospital Research Foundation
1975-80 Assistant Professor of Research Pediatrics, Children’s Hospital Research Foundation
1980-88 Adjunct Assistant Professor, Dept. Environ. Health, College of Med., Univ. of Cinti
1989-94 Adjunct Associate Professor
1995-2007 Research Associate Professor, Dept. Environ. Health
2007-2008 Adjunct Research Asociate Professor, Dept. Environ. Health

Bachelor's Degree: Westmont College Santa Barbara, CA , 1961

Doctoral Degree: University of Toronto Toronto, Ontario , 1964

Doctoral Degree: University of Cincinnati, College of Medicine, Dept. Anatomy 1971 (Quantitative Microscopy)

Postdoctoral Fellowship: University Of Cincinnati Cincinnati, OH, 1973 (Environmental Health)

2008 - Associate Professor Emerita,

Grant: #U01 ES019480 Investigators:Belcher, Scott; Ben-Jonathan, Nira; Ho, Shuk Mei; Levin, Linda; Medvedovic, Mario; Miller, Marian; Stambrook, Peter; Tso, Patrick P.W. 09-22-2010 -05-31-2015 National Institute of Environmental Health Sciences Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk Role:Collaborator $1,790,100.00 Active Level:Federal

Peer Reviewed Publications

Miller, Marian L; Porollo, Aleksey; Wert, Susan  (2018). Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species. Anatomical record (Hoboken, N.J. : 2007)More Information

Mortazavi, Smj; Bevelacqua, Joseph John; Corrice, Leslie; Dobrzy?ski, Ludwik; Feinendegen, Ludwig E; Miller, Mark L; Sacks, Bill; Ulsh, Brant; Pennington, Charles W; Welsh, James; Doss, Mohan  (2017). Comment on "Chromosomal Aberrations in Large Japanese Field Mice (Apodemus speciosus) Captured Near Fukushima Dai-ichi Nuclear Power Plant". Environmental science & technology, 51 (14) , 8196-8197More Information

Gálvez-Peralta, Marina; He, Lei; Jorge-Nebert, Lucia F; Wang, Bin; Miller, Marian L; Eppert, Bryan L; Afton, Scott; Nebert, Daniel W  (2012). ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero. PloS one, 7 (5) , e36055More Information

Zhang, Yu; Johansson, Elisabet; Miller, Marian L; Jänicke, Reiner U; Ferguson, Donald J; Plas, David; Meller, Jarek; Anderson, Marshall W  (2011). Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PloS one, 6 (9) , e25284More Information

Curran, Christine P; Vorhees, Charles V; Williams, Michael T; Genter, Mary Beth; Miller, Marian L; Nebert, Daniel W  (2011). In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological sciences : an official journal of the Society of Toxicology, 119 (1) , 189-208More Information

Xiao, Chang; Ogle, Sally A; Schumacher, Michael A; Orr-Asman, Melissa A; Miller, Marian L; Lertkowit, Nantaporn; Varro, Andrea; Hollande, Frederic; Zavros, Yana  (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology, 138 (2) , 550-61, 561.e1-8More Information

Prasad, Vikram; Bodi, Ilona; Meyer, Jamie W; Wang, Yigang; Ashraf, Muhammad; Engle, Sandra J; Doetschman, Thomas; Sisco, Karena; Nieman, Michelle L; Miller, Marian L; Lorenz, John N; Shull, Gary E  (2008). Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. The Journal of biological chemistry, 283 (46) , 31303-14More Information

Okunade, Gbolahan W; Miller, Marian L; Azhar, Mohamad; Andringa, Anastasia; Sanford, L Philip; Doetschman, Thomas; Prasad, Vikram; Shull, Gary E  (2007). Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes. The Journal of biological chemistry, 282 (36) , 26517-27More Information

Gawenis, Lara R; Bradford, Emily M; Prasad, Vikram; Lorenz, John N; Simpson, Janet E; Clarke, Lane L; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E  (2007). Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. The Journal of biological chemistry, 282 (12) , 9042-52More Information

Dragin, Nadine; Dalton, Timothy P; Miller, Marian L; Shertzer, Howard G; Nebert, Daniel W  (2006). For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. The Journal of biological chemistry, 281 (27) , 18591-600More Information

Prasad, Vikram; Boivin, Gregory P; Miller, Marian L; Liu, Lynne H; Erwin, Christopher R; Warner, Brad W; Shull, Gary E  (2005). Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer research, 65 (19) , 8655-61More Information

Gawenis, Lara R; Greeb, Jeannette M; Prasad, Vikram; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Andringa, Anastasia; Miller, Marian L; Shull, Gary E  (2005). Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. The Journal of biological chemistry, 280 (13) , 12781-9More Information

Okunade, Gbolahan W; Miller, Marian L; Pyne, Gail J; Sutliff, Roy L; O'Connor, Kyle T; Neumann, Jonathan C; Andringa, Anastasia; Miller, Daniel A; Prasad, Vikram; Doetschman, Thomas; Paul, Richard J; Shull, Gary E  (2004). Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. The Journal of biological chemistry, 279 (32) , 33742-50More Information

Gawenis, Lara R; Ledoussal, Clara; Judd, Louise M; Prasad, Vikram; Alper, Seth L; Stuart-Tilley, Alan; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E  (2004). Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. The Journal of biological chemistry, 279 (29) , 30531-9More Information

Miller, Marian L; Andringa, Anastasia; Turner, Lloyd T; Dalton, Timothy P; Derkenne, Sandrine; Nebert, Daniel W  (2003). Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth. Microscopy research and technique, 60 (5) , 528-36More Information

Woo, Alison L; Gildea, Lucy A; Tack, Leslie M; Miller, Marian L; Spicer, Zachary; Millhorn, David E; Finkelman, Fred D; Hassett, Daniel J; Shull, Gary E  (2002). In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea. The Journal of biological chemistry, 277 (50) , 49036-46More Information

Lorenz, John N; Baird, Nancy R; Judd, Louise M; Noonan, William T; Andringa, Anastasia; Doetschman, Thomas; Manning, Patrice A; Liu, Lynne H; Miller, Marian L; Shull, Gary E  (2002). Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. The Journal of biological chemistry, 277 (40) , 37871-80More Information

Ledoussal, C; Woo, A L; Miller, M L; Shull, G E  (2001). Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. American journal of physiology. Gastrointestinal and liver physiology, 281 (6) , G1385-96More Information

Spicer, Z; Miller, M L; Andringa, A; Riddle, T M; Duffy, J J; Doetschman, T; Shull, G E  (2000). Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. The Journal of biological chemistry, 275 (28) , 21555-65More Information

Dalton, T P; Miller, M L; Wu, X; Menon, A; Cianciolo, E; McKinnon, R A; Smith, P W; Robinson, L J; Nebert, D W  (2000). Refining the mouse chromosomal location of Cdm, the major gene associated with susceptibility to cadmium-induced testicular necrosis. Pharmacogenetics, 10 (2) , 141-51

Shull, G E; Miller, M L; Schultheis, P J  (2000). Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract. American journal of physiology. Gastrointestinal and liver physiology, 278 (2) , G185-90More Information

Miller, M L; Vasunia, K; Talaska, G; Andringa, A; de Boer, J; Dixon, K  (2000). The tumor promoter TPA enhances benzo[a]pyrene and benzo[a]pyrene diolepoxide mutagenesis in Big Blue mouse skin. Environmental and molecular mutagenesis, 35 (4) , 319-27

Flagella, M; Clarke, L L; Miller, M L; Erway, L C; Giannella, R A; Andringa, A; Gawenis, L R; Kramer, J; Duffy, J J; Doetschman, T; Lorenz, J N; Yamoah, E N; Cardell, E L; Shull, G E  (1999). Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. The Journal of biological chemistry, 274 (38) , 26946-55

Sutliff, R L; Weber, C S; Qian, J; Miller, M L; Clemens, T L; Paul, R J  (1999). Vasorelaxant properties of parathyroid hormone-related protein in the mouse: evidence for endothelium involvement independent of nitric oxide formation. Endocrinology, 140 (5) , 2077-83More Information

Bell, S M; Schreiner, C M; Schultheis, P J; Miller, M L; Evans, R L; Vorhees, C V; Shull, G E; Scott, W J  (1999). Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. The American journal of physiology, 276 (4 Pt 1) , C788-95

Schultheis, P J; Lorenz, J N; Meneton, P; Nieman, M L; Riddle, T M; Flagella, M; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E  (1998). Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. The Journal of biological chemistry, 273 (44) , 29150-5

Kozel, P J; Friedman, R A; Erway, L C; Yamoah, E N; Liu, L H; Riddle, T; Duffy, J J; Doetschman, T; Miller, M L; Cardell, E L; Shull, G E  (1998). Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. The Journal of biological chemistry, 273 (30) , 18693-6

Schultheis, P J; Clarke, L L; Meneton, P; Miller, M L; Soleimani, M; Gawenis, L R; Riddle, T M; Duffy, J J; Doetschman, T; Wang, T; Giebisch, G; Aronson, P S; Lorenz, J N; Shull, G E  (1998). Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nature genetics, 19 (3) , 282-5More Information

Schultheis, P J; Clarke, L L; Meneton, P; Harline, M; Boivin, G P; Stemmermann, G; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E  (1998). Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. The Journal of clinical investigation, 101 (6) , 1243-53More Information

Liu, L H; Paul, R J; Sutliff, R L; Miller, M L; Lorenz, J N; Pun, R Y; Duffy, J J; Doetschman, T; Kimura, Y; MacLennan, D H; Hoying, J B; Shull, G E  (1997). Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. The Journal of biological chemistry, 272 (48) , 30538-45

Miller, M L; Andringa, A; Albert, R E; Cody, T  (1996). Colcemid alters S phase and other parameters in skin during chronic exposure to benzo(a)pyrene. Microscopy research and technique, 35 (4) , 307-13More Information

Albert, R E; Miller, M L; Cody, T E; Talaska, G; Underwood, P; Andringa, A  (1996). Epidermal cytokinetics, DNA adducts, and dermal inflammation in the mouse skin in response to repeated benzo[a]pyrene exposures. Toxicology and applied pharmacology, 136 (1) , 67-74More Information

Evans, J E; Miller, M L; Andringa, A; Hastings, L  (1995). Behavioral, histological, and neurochemical effects of nickel (II) on the rat olfactory system. Toxicology and applied pharmacology, 130 (2) , 209-20More Information

Swiecichowski, A L; Long, K J; Miller, M L; Leikauf, G D  (1993). Formaldehyde-induced airway hyperreactivity in vivo and ex vivo in guinea pigs. Environmental research, 61 (2) , 185-99More Information

Cibulas, W; Brooks, S M; Murlas, C G; Miller, M L; McKay, R T  (1988). Toluene diisocyanate-induced airway hyperreactivity in guinea pigs depleted of granulocytes. Journal of applied physiology (Bethesda, Md. : 1985), 64 (5) , 1773-8More Information

Schumann, B L; Cody, T E; Miller, M L; Leikauf, G D  (1988). Isolation, characterization, and long-term culture of fetal bovine tracheal epithelial cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 24 (3) , 211-6