Jeffery Molkentin

Jeffery D Molkentin , Ph.D.

Professor-Affiliate

Cincinnati Children's Hospital Medical Center
240 Albert Sabin Way, MLC7020
Molecular Cardiovascular Biology
Cincinnati, Ohio 45229
Phone 513-636-3557
Fax 513-636-5958
Email jeff.molkentin@cchmc.org

Professional Summary

Dr Molkentin received his PhD from the Medical College of Wisconsin (USA) in 1994, after which he performed postdoctoral training with Dr. Eric Olson in Texas (USA) from 1994-1997, followed by his first faculty appointment in 1997 at the Cincinnati Children’s Hospital Medical Center of the University of Cincinnati (USA), where today he is a Full Professor.  Dr. Molkentin has published over 315 original articles during this time and is funded with multiple NIH grant awards.  Dr. Molkentin was a Pew Scholar early in his career and is now a full investigator of the Howard Hughes Medical Institute in the USA. Dr. Molkentin’s research program continues to focus on the identification of candidate genes and signaling pathways involved in cardiac hypertrophy, contractility, cell death, heart failure, and muscular dystrophy, as well as mitochondria-dependent necrosis. Dr. Molkentin has placed most of his 60+ trainees in academics or the pharmaceutical industry.

Education

B.S.: Marquette University Milwaukee, WI, 1989 (Biology)

PhD: Medical College of Wisconsin Milwaukee, WI, 1994 (Physiology)

Research and Practice Interests

Molecular biology of heart and skeletal muscle disease

Research Support

Grant: #P0220SC-04-A0-S0-E0 Investigators:Molkentin, Jeffrey 07-01-1998 -06-30-2003 Pew Charitable Trusts Transcriptional Control of Cardiac Myogenesis Role:PI $230,000.00 Closed Level:Private Non-Profit

Publications

Peer Reviewed Publications

Pereira, Ana Helena M; Cardoso, Alisson C; Consonni, Silvio R; Oliveira, Renata R; Saito, Angela; Vaggione, Maria Luisa B; Matos-Souza, Jose R; Carazzolle, Marcelo F; Gonçalves, Anderson; Fernandes, Juliano L; Ribeiro, Gustavo C A; Lopes, Mauricio M; Molkentin, Jeffery D; Franchini, Kleber G (2020. ) MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.EBioMedicine, , 51 ,102571 More Information

Vagnozzi, Ronald J; Maillet, Marjorie; Sargent, Michelle A; Khalil, Hadi; Johansen, Anne Katrine Z; Schwanekamp, Jennifer A; York, Allen J; Huang, Vincent; Nahrendorf, Matthias; Sadayappan, Sakthivel; Molkentin, Jeffery D (2020. ) An acute immune response underlies the benefit of cardiac stem cell therapy.Nature, , 577 (7790 ) ,405-409 More Information

Antonucci, Salvatore; Di Sante, Moises; Sileikyte, Justina; Deveraux, Jordan; Bauer, Tyler; Bround, Michael J; Menabò, Roberta; Paillard, Melanie; Alanova, Petra; Carraro, Michela; Ovize, Michel; Molkentin, Jeffery D; Cohen, Michael; Forte, Michael A; Bernardi, Paolo; Di Lisa, Fabio; Murphy, Elizabeth (2020. ) A novel class of cardioprotective small-molecule PTP inhibitors.Pharmacological research, , 151 ,104548 More Information

Vagnozzi, Ronald J; Johansen, Anne Katrine Z; Molkentin, Jeffery D (2019. ) CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart.Molecular therapy : the journal of the American Society of Gene Therapy, , 27 (11 ) ,1869-1871 More Information

Johansen, Anne Katrine Z; Molkentin, Jeffery D (2019. ) Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation.Genes & development, , 33 (21-22 ) ,1457-1459 More Information

Wang, Yuhua; Pandey, Ram Naresh; York, Allen J; Mallela, Jaya; Nichols, William C; Hu, Yueh-Chiang; Molkentin, Jeffery D; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S (2019. ) The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.Nature communications, , 10 (1 ) ,4143 More Information

Karch, Jason; Bround, Michael J; Khalil, Hadi; Sargent, Michelle A; Latchman, Nadina; Terada, Naohiro; Peixoto, Pablo M; Molkentin, Jeffery D (2019. ) Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.Science advances, , 5 (8 ) ,eaaw4597 More Information

Khalil, Hadi; Kanisicak, Onur; Vagnozzi, Ronald J.; Johansen, Anne Katrine; Maliken, Bryan D.; Prasad, Vikram; Boyer, Justin G.; Brody, Matthew J.; Schips, Tobias; Kilian, Katja K.; Correll, Robert N.; Kawasaki, Kunito; Nagata, Kazuhiro; Molkentin, Jeffery D. (2019. ) Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart.JCI insight, , 4 (15 ) ,e128722 More Information

Brody, Matthew J; Vanhoutte, Davy; Bakshi, Chinmay V; Liu, Ruije; Correll, Robert N; Sargent, Michelle A; Molkentin, Jeffery D (2019. ) Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.The Journal of biological chemistry, , 294 (22 ) ,8918-8929 More Information

Murphy, Elizabeth; Bernardi, Paolo; Cohen, Michael; Di Lisa, Fabio; Forte, Michael; Molkentin, Jeffery D; Ovize, Michel (2019. ) Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease.Circulation research, , 124 (9 ) ,1294-1296 More Information

Boyer, Justin G; Prasad, Vikram; Song, Taejeong; Lee, Donghoon; Fu, Xing; Grimes, Kelly M; Sargent, Michelle A; Sadayappan, Sakthivel; Molkentin, Jeffery D (2019. ) ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.JCI insight, , 5 , More Information

Correll, Robert N; Grimes, Kelly M; Prasad, Vikram; Lynch, Jeffrey M; Khalil, Hadi; Molkentin, Jeffery D (2019. ) Overlapping and differential functions of ATF6? versus ATF6? in the mouse heart.Scientific reports, , 9 (1 ) ,2059 More Information

Altamimi, Tariq R; Karwi, Qutuba G; Uddin, Golam Mezbah; Fukushima, Arata; Kwong, Jennifer Q; Molkentin, Jeffery D; Lopaschuk, Gary D (2019. ) Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.Journal of molecular and cellular cardiology, , 127 ,223-231 More Information

Schips, Tobias G; Vanhoutte, Davy; Vo, Alexander; Correll, Robert N; Brody, Matthew J; Khalil, Hadi; Karch, Jason; Tjondrokoesoemo, Andoria; Sargent, Michelle A; Maillet, Marjorie; Ross, Robert S; Molkentin, Jeffery D (2019. ) Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.Nature communications, , 10 (1 ) ,76 More Information

Neidig, Lauren E; Weinberger, Florian; Palpant, Nathan J; Mignone, John; Martinson, Amy M; Sorensen, Daniel W; Bender, Ingrid; Nemoto, Natsumi; Reinecke, Hans; Pabon, Lil; Molkentin, Jeffery D; Murry, Charles E; van Berlo, Jop H (2018. ) Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart.Circulation, , 138 (25 ) ,2960-2962 More Information

Vagnozzi, Ronald J; Sargent, Michelle A; Lin, Suh-Chin J; Palpant, Nathan J; Murry, Charles E; Molkentin, Jeffery D (2018. ) Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart.Circulation, , 138 (25 ) ,2931-2939 More Information

Meng, Qinghang; Bhandary, Bidur; Bhuiyan, Md Shenuarin; James, Jeanne; Osinska, Hanna; Valiente-Alandi, Iñigo; Shay-Winkler, Kritton; Gulick, James; Molkentin, Jeffery D; Blaxall, Burns C; Robbins, Jeffrey (2018. ) Myofibroblast-Specific TGF? Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.Circulation research, , 123 (12 ) ,1285-1297 More Information

Kwong, Jennifer Q; Huo, Jiuzhou; Bround, Michael J; Boyer, Justin G; Schwanekamp, Jennifer A; Ghazal, Nasab; Maxwell, Joshua T; Jang, Young C; Khuchua, Zaza; Shi, Kevin; Bers, Donald M; Davis, Jennifer; Molkentin, Jeffery D (2018. ) The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle.JCI insight, , 3 (22 ) , More Information

Olivares-Florez, Silvana; Czolbe, Martin; Riediger, Fabian; Seidlmayer, Lea; Williams, Tatjana; Nordbeck, Peter; Strasen, Jörn; Glocker, Cristina; Jänsch, Monique; Eder-Negrin, Petra; Arias-Loza, Paula; Mühlfelder, Melanie; Pla?ki?, Jelena; Heinze, Katrin G; Molkentin, Jeffery D; Engelhardt, Stefan; Kockskämper, Jens; Ritter, Oliver (2018. ) Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R.Journal of molecular medicine (Berlin, Germany), , 96 (11 ) ,1239-1249 More Information

Bhandary, Bidur; Meng, Qinghang; James, Jeanne; Osinska, Hanna; Gulick, James; Valiente-Alandi, Iñigo; Sargent, Michelle A; Bhuiyan, Md Shenuarin; Blaxall, Burns C; Molkentin, Jeffery D; Robbins, Jeffrey (2018. ) Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -? Signaling.Journal of the American Heart Association, , 7 (20 ) ,e010013 More Information

Valiente-Alandi, Iñigo; Potter, Sarah J; Salvador, Ane M; Schafer, Allison E; Schips, Tobias; Carrillo-Salinas, Francisco; Gibson, Aaron M; Nieman, Michelle L; Perkins, Charles; Sargent, Michelle A; Huo, Jiuzhou; Lorenz, John N; DeFalco, Tony; Molkentin, Jeffery D; Alcaide, Pilar; Blaxall, Burns C (2018. ) Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.Circulation, , 138 (12 ) ,1236-1252 More Information

Stremmel, C; Schuchert, R; Wagner, F; Thaler, R; Weinberger, T; Pick, R; Mass, E; Ishikawa-Ankerhold, H C; Margraf, A; Hutter, S; Vagnozzi, R; Klapproth, S; Frampton, J; Yona, S; Scheiermann, C; Molkentin, J D; Jeschke, U; Moser, M; Sperandio, M; Massberg, S; Geissmann, F; Schulz, C (2018. ) Author Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.Nature communications, , 9 (1 ) ,3699 More Information

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D (2018. ) Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart.Circulation, , 138 (10 ) ,1012-1024 More Information

Maliken, Bryan D; Molkentin, Jeffery D (2018. ) Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.Circulation, , 138 (8 ) ,806-808 More Information

Schulz, Franziska; Westreicher-Kristen, Edwin; Molkentin, Joachim; Knappstein, Karin; Susenbeth, Andreas (2018. ) Effect of replacing maize silage with red clover silage in the diet on milk fatty acid composition in cows.Journal of dairy science, , 101 (8 ) ,7156-7167 More Information

Vagnozzi, Ronald J; Molkentin, Jeffery D; Houser, Steven R (2018. ) New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.Circulation research, , 123 (2 ) ,159-176 More Information

Brody, Matthew J; Vanhoutte, Davy; Schips, Tobias G; Boyer, Justin G; Bakshi, Chinmay V; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D (2018. ) Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.Molecular and cellular biology, , 38 (14 ) , More Information

Nayak, Gowri; Odaka, Yoshinobu; Prasad, Vikram; Solano, Alyssa F; Yeo, Eun-Jin; Vemaraju, Shruti; Molkentin, Jeffery D; Trumpp, Andreas; Williams, Bart; Rao, Sujata; Lang, Richard A (2018. ) Developmental vascular regression is regulated by a Wnt/?-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.Development (Cambridge, England), , 145 (12 ) , More Information

Fu, Xing; Khalil, Hadi; Kanisicak, Onur; Boyer, Justin G; Vagnozzi, Ronald J; Maliken, Bryan D; Sargent, Michelle A; Prasad, Vikram; Valiente-Alandi, Iñigo; Blaxall, Burns C; Molkentin, Jeffery D (2018. ) Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.The Journal of clinical investigation, , 128 (5 ) ,2127-2143 More Information

Melfsen, Andreas; Holstermann, Max; Haeussermann, Angelika; Molkentin, Joachim; Susenbeth, Andreas; Hartung, Eberhard (2018. ) Accuracy and application of milk fatty acid estimation with diffuse reflectance near-infrared spectroscopy.The Journal of dairy research, , 85 (2 ) ,212-221 More Information

Li, Yingxin; Zhang, Xiaoxiao; Zhang, Chen; Zhang, Xiaoying; Li, Ying; Qi, Zhao; Szeto, Christopher; Tang, Mingxin; Peng, Yizhi; Molkentin, Jeffery D; Houser, Steven R; Xie, Mingxing; Chen, Xiongwen (2018. ) Increasing T-type calcium channel activity by ?-adrenergic stimulation contributes to ?-adrenergic regulation of heart rates.The Journal of physiology, , 596 (7 ) ,1137-1151 More Information

van Berlo, Jop H; Kanisicak, Onur; Maillet, Marjorie; Vagnozzi, Ronald J; Karch, Jason; Lin, Suh-Chin J; Middleton, Ryan C; Marbán, Eduardo; Molkentin, Jeffery D (2018. ) van Berlo et al. reply.Nature, , 555 (7697 ) ,E18 More Information

Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S; Altucci, Lucia; Amelio, Ivano; Andrews, David W; Annicchiarico-Petruzzelli, Margherita; Antonov, Alexey V; Arama, Eli; Baehrecke, Eric H; Barlev, Nickolai A; Bazan, Nicolas G; Bernassola, Francesca; Bertrand, Mathieu J M; Bianchi, Katiuscia; Blagosklonny, Mikhail V; Blomgren, Klas; Borner, Christoph; Boya, Patricia; Brenner, Catherine; Campanella, Michelangelo; Candi, Eleonora; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chandel, Navdeep S; Cheng, Emily H; Chipuk, Jerry E; Cidlowski, John A; Ciechanover, Aaron; Cohen, Gerald M; Conrad, Marcus; Cubillos-Ruiz, Juan R; Czabotar, Peter E; D'Angiolella, Vincenzo; Dawson, Ted M; Dawson, Valina L; De Laurenzi, Vincenzo; De Maria, Ruggero; Debatin, Klaus-Michael; DeBerardinis, Ralph J; Deshmukh, Mohanish; Di Daniele, Nicola; Di Virgilio, Francesco; Dixit, Vishva M; Dixon, Scott J; Duckett, Colin S; Dynlacht, Brian D; El-Deiry, Wafik S; Elrod, John W; Fimia, Gian Maria; Fulda, Simone; García-Sáez, Ana J; Garg, Abhishek D; Garrido, Carmen; Gavathiotis, Evripidis; Golstein, Pierre; Gottlieb, Eyal; Green, Douglas R; Greene, Lloyd A; Gronemeyer, Hinrich; Gross, Atan; Hajnoczky, Gyorgy; Hardwick, J Marie; Harris, Isaac S; Hengartner, Michael O; Hetz, Claudio; Ichijo, Hidenori; Jäättelä, Marja; Joseph, Bertrand; Jost, Philipp J; Juin, Philippe P; Kaiser, William J; Karin, Michael; Kaufmann, Thomas; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N; Klionsky, Daniel J; Knight, Richard A; Kumar, Sharad; Lee, Sam W; Lemasters, John J; Levine, Beth; Linkermann, Andreas; Lipton, Stuart A; Lockshin, Richard A; López-Otín, Carlos; Lowe, Scott W; Luedde, Tom; Lugli, Enrico; MacFarlane, Marion; Madeo, Frank; Malewicz, Michal; Malorni, Walter; Manic, Gwenola; Marine, Jean-Christophe; Martin, Seamus J; Martinou, Jean-Claude; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Sonia; Miao, Edward A; Molkentin, Jeffery D; Moll, Ute M; Muñoz-Pinedo, Cristina; Nagata, Shigekazu; Nuñez, Gabriel; Oberst, Andrew; Oren, Moshe; Overholtzer, Michael; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M; Pereira, David M; Pervaiz, Shazib; Peter, Marcus E; Piacentini, Mauro; Pinton, Paolo; Prehn, Jochen H M; Puthalakath, Hamsa; Rabinovich, Gabriel A; Rehm, Markus; Rizzuto, Rosario; Rodrigues, Cecilia M P; Rubinsztein, David C; Rudel, Thomas; Ryan, Kevin M; Sayan, Emre; Scorrano, Luca; Shao, Feng; Shi, Yufang; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stockwell, Brent R; Strasser, Andreas; Szabadkai, Gyorgy; Tait, Stephen W G; Tang, Daolin; Tavernarakis, Nektarios; Thorburn, Andrew; Tsujimoto, Yoshihide; Turk, Boris; Vanden Berghe, Tom; Vandenabeele, Peter; Vander Heiden, Matthew G; Villunger, Andreas; Virgin, Herbert W; Vousden, Karen H; Vucic, Domagoj; Wagner, Erwin F; Walczak, Henning; Wallach, David; Wang, Ying; Wells, James A; Wood, Will; Yuan, Junying; Zakeri, Zahra; Zhivotovsky, Boris; Zitvogel, Laurence; Melino, Gerry; Kroemer, Guido (2018. ) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Cell death and differentiation, , 25 (3 ) ,486-541 More Information

Hu, Ray; Morley, Michael P; Brandimarto, Jeffrey; Tucker, Nathan R; Parsons, Victoria A; Zhao, Sihai D; Meder, Benjamin; Katus, Hugo A; Rühle, Frank; Stoll, Monika; Villard, Eric; Cambien, François; Lin, Honghuang; Smith, Nicholas L; Felix, Janine F; Vasan, Ramachandran S; van der Harst, Pim; Newton-Cheh, Christopher; Li, Jin; Kim, Cecilia E; Hakonarson, Hakon; Hannenhalli, Sridhar; Ashley, Euan A; Moravec, Christine S; Tang, W H Wilson; Maillet, Marjorie; Molkentin, Jeffery D; Ellinor, Patrick T; Margulies, Kenneth B; Cappola, Thomas P (2018. ) Genetic Reduction in Left Ventricular Protein Kinase C-? and Adverse Ventricular Remodeling in Human Subjects.Circulation. Genomic and precision medicine, , 11 (3 ) ,e001901 More Information

Schulz, Franziska; Westreicher-Kristen, Edwin; Knappstein, Karin; Molkentin, Joachim; Susenbeth, Andreas (2018. ) Replacing maize silage plus soybean meal with red clover silage plus wheat in diets for lactating dairy cows.Journal of dairy science, , 101 (2 ) ,1216-1226 More Information

Stremmel, C; Schuchert, R; Wagner, F; Thaler, R; Weinberger, T; Pick, R; Mass, E; Ishikawa-Ankerhold, H C; Margraf, A; Hutter, S; Vagnozzi, R; Klapproth, S; Frampton, J; Yona, S; Scheiermann, C; Molkentin, J D; Jeschke, U; Moser, M; Sperandio, M; Massberg, S; Geissmann, F; Schulz, C (2018. ) Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.Nature communications, , 9 (1 ) ,75 More Information

Sharp, Thomas E; Kubo, Hajime; Berretta, Remus M; Starosta, Timothy; Wallner, Markus; Schena, Giana J; Hobby, Alexander R; Yu, Daohai; Trappanese, Danielle M; George, Jon C; Molkentin, Jeffery D; Houser, Steven R (2017. ) Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction.JACC. Basic to translational science, , 2 (6 ) ,669-683 More Information

Accornero, Federica; Schips, Tobias G; Petrosino, Jennifer M; Gu, Shan-Qing; Kanisicak, Onur; van Berlo, Jop H; Molkentin, Jeffery D (2017. ) BEX1 is an RNA-dependent mediator of cardiomyopathy.Nature communications, , 8 (1 ) ,1875 More Information

Karch, Jason; Schips, Tobias G; Maliken, Bryan D; Brody, Matthew J; Sargent, Michelle A; Kanisicak, Onur; Molkentin, Jeffery D (2017. ) Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.eLife, , 6 , More Information

Kanisicak, Onur; Vagnozzi, Ronald J; Molkentin, Jeffery D (2017. ) Identity Crisis for Regenerative Cardiac cKit+ Cells.Circulation research, , 121 (10 ) ,1130-1132 More Information

Khalil, Hadi; Maillet, Marjorie; Molkentin, Jeffery D (2017. ) Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX.Circulation, , 136 (15 ) ,1410-1411 More Information

Khalil, Hadi; Kanisicak, Onur; Prasad, Vikram; Correll, Robert N; Fu, Xing; Schips, Tobias; Vagnozzi, Ronald J; Liu, Ruijie; Huynh, Thanh; Lee, Se-Jin; Karch, Jason; Molkentin, Jeffery D (2017. ) Fibroblast-specific TGF-?-Smad2/3 signaling underlies cardiac fibrosis.The Journal of clinical investigation, , 127 (10 ) ,3770-3783 More Information

Klir, Z; Castro-Montoya, J M; Novoselec, J; Molkentin, J; Domacinovic, M; Mioc, B; Dickhoefer, U; Antunovic, Z (2017. ) Influence of pumpkin seed cake and extruded linseed on milk production and milk fatty acid profile in Alpine goats.Animal : an international journal of animal bioscience, , 11 (10 ) ,1772-1778 More Information

Molkentin, Jan-Philip; Nägele, Matthias P; Frank, Michelle; Sudano, Isabella; Enseleit, Frank; Wilhelm, Markus J; Lüscher, Thomas F; Maisano, Francesco; Ruschitzka, Frank; Flammer, Andreas J (2017. ) Prognostic value of mean pulmonary artery pressure in the stable phase after heart transplantation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, , 52 (4 ) ,775-780 More Information

McLendon, Patrick M; Davis, Gregory; Gulick, James; Singh, Sonia R; Xu, Na; Salomonis, Nathan; Molkentin, Jeffery D; Robbins, Jeffrey (2017. ) An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels.Circulation research, , 121 (6 ) ,604-616 More Information

Travers, Joshua G; Kamal, Fadia A; Valiente-Alandi, Iñigo; Nieman, Michelle L; Sargent, Michelle A; Lorenz, John N; Molkentin, Jeffery D; Blaxall, Burns C (2017. ) Pharmacological and Activated Fibroblast Targeting of G??-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.Journal of the American College of Cardiology, , 70 (8 ) ,958-971 More Information

Eschenhagen, Thomas; Bolli, Roberto; Braun, Thomas; Field, Loren J; Fleischmann, Bernd K; Frisén, Jonas; Giacca, Mauro; Hare, Joshua M; Houser, Steven; Lee, Richard T; Marbán, Eduardo; Martin, James F; Molkentin, Jeffery D; Murry, Charles E; Riley, Paul R; Ruiz-Lozano, Pilar; Sadek, Hesham A; Sussman, Mark A; Hill, Joseph A (2017. ) Cardiomyocyte Regeneration: A Consensus Statement.Circulation, , 136 (7 ) ,680-686 More Information

Molkentin, Jeffery D; Bugg, Darrian; Ghearing, Natasha; Dorn, Lisa E; Kim, Peter; Sargent, Michelle A; Gunaje, Jagadambika; Otsu, Kinya; Davis, Jennifer (2017. ) Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.Circulation, , 136 (6 ) ,549-561 More Information

He, Lingjuan; Huang, Xiuzhen; Kanisicak, Onur; Li, Yi; Wang, Yue; Li, Yan; Pu, Wenjuan; Liu, Qiaozhen; Zhang, Hui; Tian, Xueying; Zhao, Huan; Liu, Xiuxiu; Zhang, Shaohua; Nie, Yu; Hu, Shengshou; Miao, Xiang; Wang, Qing-Dong; Wang, Fengchao; Chen, Ting; Xu, Qingbo; Lui, Kathy O; Molkentin, Jeffery D; Zhou, Bin (2017. ) Preexisting endothelial cells mediate cardiac neovascularization after injury.The Journal of clinical investigation, , 127 (8 ) ,2968-2981 More Information

Henke, Anika; Westreicher-Kristen, Edwin; Molkentin, Joachim; Dickhoefer, Uta; Knappstein, Karin; Hasler, Mario; Susenbeth, Andreas (2017. ) Effect of dietary quebracho tannin extract on milk fatty acid composition in cows.Journal of dairy science, , 100 (8 ) ,6229-6238 More Information

Tallquist, Michelle D; Molkentin, Jeffery D (2017. ) Redefining the identity of cardiac fibroblasts.Nature reviews. Cardiology, , 14 (8 ) ,484-491 More Information

Schwanekamp, Jennifer A; Lorts, Angela; Sargent, Michelle A; York, Allen J; Grimes, Kelly M; Fischesser, Demetria M; Gokey, Jason J; Whitsett, Jeffrey A; Conway, Simon J; Molkentin, Jeffery D (2017. ) TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.PloS one, , 12 (7 ) ,e0181945 More Information

Correll, Robert N; Lynch, Jeffrey M; Schips, Tobias G; Prasad, Vikram; York, Allen J; Sargent, Michelle A; Brochet, Didier X P; Ma, Jianjie; Molkentin, Jeffery D (2017. ) Mitsugumin 29 regulates t-tubule architecture in the failing heart.Scientific reports, , 7 (1 ) ,5328 More Information

Correll, Robert N; Makarewich, Catherine A; Zhang, Hongyu; Zhang, Chen; Sargent, Michelle A; York, Allen J; Berretta, Remus M; Chen, Xiongwen; Houser, Steven R; Molkentin, Jeffery D (2017. ) Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.Cardiovascular research, , 113 (7 ) ,749-759 More Information

Luongo, Timothy S; Lambert, Jonathan P; Gross, Polina; Nwokedi, Mary; Lombardi, Alyssa A; Shanmughapriya, Santhanam; Carpenter, April C; Kolmetzky, Devin; Gao, Erhe; van Berlo, Jop H; Tsai, Emily J; Molkentin, Jeffery D; Chen, Xiongwen; Madesh, Muniswamy; Houser, Steven R; Elrod, John W (2017. ) The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.Nature, , 545 (7652 ) ,93-97 More Information

Henke, Anika; Dickhoefer, Uta; Westreicher-Kristen, Edwin; Knappstein, Karin; Molkentin, Joachim; Hasler, Mario; Susenbeth, Andreas (2017. ) Effect of dietary Quebracho tannin extract on feed intake, digestibility, excretion of urinary purine derivatives and milk production in dairy cows.Archives of animal nutrition, , 71 (1 ) ,37-53 More Information

Cai, Chen-Leng; Molkentin, Jeffery D (2017. ) The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away.Circulation research, , 120 (2 ) ,400-406 More Information

Kanisicak, Onur; Molkentin, Jeffery D (2016. ) Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast.JACC. Basic to translational science, , 1 (7 ) ,603-605 More Information

Kim, Jung Ha; Kim, Kabsun; Kim, Inyoung; Seong, Semun; Jeong, Byung-Chul; Nam, Kwang-Il; Kim, Kyung Keun; Molkentin, Jeffery D; Kim, Nacksung (2016. ) RCANs regulate the convergent roles of NFATc1 in bone homeostasis.Scientific reports, , 6 ,38526 More Information

Cunha, Daniel A; Cito, Monia; Carlsson, Per-Ola; Vanderwinden, Jean-Marie; Molkentin, Jeffery D; Bugliani, Marco; Marchetti, Piero; Eizirik, Décio L; Cnop, Miriam (2016. ) Thrombospondin 1 protects pancreatic ?-cells from lipotoxicity via the PERK-NRF2 pathway.Cell death and differentiation, , 23 (12 ) ,1995-2006 More Information

Liu, Ruijie; Molkentin, Jeffery D (2016. ) Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).Journal of molecular and cellular cardiology, , 101 ,44-49 More Information

Liu, Ruijie; Khalil, Hadi; Lin, Suh-Chin J; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D (2016. ) Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.PloS one, , 11 (10 ) ,e0164897 More Information

Seidlmayer, Lea K; Kuhn, Johannes; Berbner, Annette; Arias-Loza, Paula-Anahi; Williams, Tatjana; Kaspar, Mathias; Czolbe, Martin; Kwong, Jennifer Q; Molkentin, Jeffery D; Heinze, Katrin Gertrud; Dedkova, Elena N; Ritter, Oliver (2016. ) Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.Cardiovascular research, , 112 (1 ) ,491-501 More Information

Vanhoutte, Davy; Schips, Tobias G; Kwong, Jennifer Q; Davis, Jennifer; Tjondrokoesoemo, Andoria; Brody, Matthew J; Sargent, Michelle A; Kanisicak, Onur; Yi, Hong; Gao, Quan Q; Rabinowitz, Joseph E; Volk, Talila; McNally, Elizabeth M; Molkentin, Jeffery D (2016. ) Thrombospondin expression in myofibers stabilizes muscle membranes.eLife, , 5 , More Information

Wallner, Markus; Duran, Jason M; Mohsin, Sadia; Troupes, Constantine D; Vanhoutte, Davy; Borghetti, Giulia; Vagnozzi, Ronald J; Gross, Polina; Yu, Daohai; Trappanese, Danielle M; Kubo, Hajime; Toib, Amir; Sharp, Thomas E; Harper, Shavonn C; Volkert, Michael A; Starosta, Timothy; Feldsott, Eric A; Berretta, Remus M; Wang, Tao; Barbe, Mary F; Molkentin, Jeffrey D; Houser, Steven R (2016. ) Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.Circulation research, , 119 (7 ) ,865-79 More Information

Mukherjee, Rajarshi; Mareninova, Olga A; Odinokova, Irina V; Huang, Wei; Murphy, John; Chvanov, Michael; Javed, Muhammad A; Wen, Li; Booth, David M; Cane, Matthew C; Awais, Muhammad; Gavillet, Bruno; Pruss, Rebecca M; Schaller, Sophie; Molkentin, Jeffery D; Tepikin, Alexei V; Petersen, Ole H; Pandol, Stephen J; Gukovsky, Ilya; Criddle, David N; Gukovskaya, Anna S; Sutton, Robert (2016. ) Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.Gut, , 65 (8 ) ,1333-46 More Information

Kanisicak, Onur; Khalil, Hadi; Ivey, Malina J; Karch, Jason; Maliken, Bryan D; Correll, Robert N; Brody, Matthew J; J Lin, Suh-Chin; Aronow, Bruce J; Tallquist, Michelle D; Molkentin, Jeffery D (2016. ) Genetic lineage tracing defines myofibroblast origin and function in the injured heart.Nature communications, , 7 ,12260 More Information

Liu, Ruijie; van Berlo, Jop H; York, Allen J; Vagnozzi, Ronald J; Maillet, Marjorie; Molkentin, Jeffery D (2016. ) DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.Circulation research, , 119 (2 ) ,249-60 More Information

Davis, Jennifer; Davis, L Craig; Correll, Robert N; Makarewich, Catherine A; Schwanekamp, Jennifer A; Moussavi-Harami, Farid; Wang, Dan; York, Allen J; Wu, Haodi; Houser, Steven R; Seidman, Christine E; Seidman, Jonathan G; Regnier, Michael; Metzger, Joseph M; Wu, Joseph C; Molkentin, Jeffery D (2016. ) A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Cell, , 165 (5 ) ,1147-1159 More Information

Tjondrokoesoemo, Andoria; Schips, Tobias G; Sargent, Michelle A; Vanhoutte, Davy; Kanisicak, Onur; Prasad, Vikram; Lin, Suh-Chin J; Maillet, Marjorie; Molkentin, Jeffery D (2016. ) Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice.The Journal of biological chemistry, , 291 (19 ) ,9920-8 More Information

Lamar, Kay-Marie; Bogdanovich, Sasha; Gardner, Brandon B; Gao, Quan Q; Miller, Tamari; Earley, Judy U; Hadhazy, Michele; Vo, Andy H; Wren, Lisa; Molkentin, Jeffery D; McNally, Elizabeth M (2016. ) Overexpression of Latent TGF? Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGF?.PLoS genetics, , 12 (5 ) ,e1006019 More Information

Zhu, Xiang; Hogan, Simon P; Molkentin, Jeffery D; Zimmermann, Nives (2016. ) Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils.American journal of physiology. Gastrointestinal and liver physiology, , 310 (8 ) ,G609-17 More Information

Tjondrokoesoemo, Andoria; Schips, Tobias; Kanisicak, Onur; Sargent, Michelle A; Molkentin, Jeffery D (2016. ) Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.Human molecular genetics, , 25 (6 ) ,1192-202 More Information

Lu, Xiyuan; Kwong, Jennifer Q; Molkentin, Jeffery D; Bers, Donald M (2016. ) Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings.Circulation research, , 118 (5 ) ,834-41 More Information

van Berlo, Jop H; Molkentin, Jeffery D (2016. ) Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo.Circulation research, , 118 (1 ) ,17-9 More Information

Schwanekamp, Jennifer A; Lorts, Angela; Vagnozzi, Ronald J; Vanhoutte, Davy; Molkentin, Jeffery D (2016. ) Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling.Arteriosclerosis, thrombosis, and vascular biology, , 36 (1 ) ,60-8 More Information

Zhang, Xiaoying; Ai, Xiaojie; Nakayama, Hiroyuki; Chen, Biyi; Harris, David M; Tang, Mingxin; Xie, Yuping; Szeto, Christopher; Li, Yingxin; Li, Ying; Zhang, Hongyu; Eckhart, Andrea D; Koch, Walter J; Molkentin, Jeffery D; Chen, Xiongwen (2016. ) Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.Basic research in cardiology, , 111 (1 ) ,4 More Information

Davis, Jennifer; Salomonis, Nathan; Ghearing, Natasha; Lin, Suh-Chin J; Kwong, Jennifer Q; Mohan, Apoorva; Swanson, Maurice S; Molkentin, Jeffery D (2015. ) MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.Nature communications, , 6 ,10084 More Information

Li, Lei; Chen, Yi; Li, Jing; Yin, Haifeng; Guo, Xiaoyun; Doan, Jessica; Molkentin, Jeffery D; Liu, Qinghang (2015. ) TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NF?B, and Bnip3 Pathways.Scientific reports, , 5 ,16626 More Information

Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H (2015. ) Calcineurin Links Mitochondrial Elongation with Energy Metabolism.Cell metabolism, , 22 (5 ) ,838-50 More Information

Brody, Matthew J; Schips, Tobias G; Vanhoutte, Davy; Kanisicak, Onur; Karch, Jason; Maliken, Bryan D; Blair, N Scott; Sargent, Michelle A; Prasad, Vikram; Molkentin, Jeffery D (2016. ) Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.Molecular and cellular biology, , 36 (1 ) ,2-12 More Information

Liu, Ruijie; Correll, Robert N; Davis, Jennifer; Vagnozzi, Ronald J; York, Allen J; Sargent, Michelle A; Nairn, Angus C; Molkentin, Jeffery D (2015. ) Cardiac-specific deletion of protein phosphatase 1? promotes increased myofilament protein phosphorylation and contractile alterations.Journal of molecular and cellular cardiology, , 87 ,204-13 More Information

Correll, Robert N; Goonasekera, Sanjeewa A; van Berlo, Jop H; Burr, Adam R; Accornero, Federica; Zhang, Hongyu; Makarewich, Catherine A; York, Allen J; Sargent, Michelle A; Chen, Xiongwen; Houser, Steven R; Molkentin, Jeffery D (2015. ) STIM1 elevation in the heart results in aberrant Ca²? handling and cardiomyopathy.Journal of molecular and cellular cardiology, , 87 ,38-47 More Information

Burr, A R; Molkentin, J D (2015. ) Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy.Cell death and differentiation, , 22 (9 ) ,1402-12 More Information

Jin, Shunqian; Orabi, Abrahim I; Le, Tianming; Javed, Tanveer A; Sah, Swati; Eisses, John F; Bottino, Rita; Molkentin, Jeffery D; Husain, Sohail Z (2015. ) Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-?B, Calcium Signaling, and Calcineurin.Gastroenterology, , 149 (3 ) ,753-64.e11 More Information

Gainutdinov, T; Molkentin, J D; Siemen, D; Ziemer, M; Debska-Vielhaber, G; Vielhaber, S; Gizatullina, Z; Orynbayeva, Z; Gellerich, F N (2015. ) Knockout of cyclophilin D in Ppif?/? mice increases stability of brain mitochondria against Ca²? stress.Archives of biochemistry and biophysics, , 579 ,40-6 More Information

Shojaee, Seyedmehdi; Caeser, Rebecca; Buchner, Maike; Park, Eugene; Swaminathan, Srividya; Hurtz, Christian; Geng, Huimin; Chan, Lai N; Klemm, Lars; Hofmann, Wolf-Karsten; Qiu, Yi Hua; Zhang, Nianxiang; Coombes, Kevin R; Paietta, Elisabeth; Molkentin, Jeffery; Koeffler, H Phillip; Willman, Cheryl L; Hunger, Stephen P; Melnick, Ari; Kornblau, Steven M; Müschen, Markus (2015. ) Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.Cancer cell, , 28 (1 ) ,114-28 More Information

Kwong, Jennifer Q; Lu, Xiyuan; Correll, Robert N; Schwanekamp, Jennifer A; Vagnozzi, Ronald J; Sargent, Michelle A; York, Allen J; Zhang, Jianyi; Bers, Donald M; Molkentin, Jeffery D (2015. ) The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.Cell reports, , 12 (1 ) ,15-22 More Information

Karch, Jason; Kanisicak, Onur; Brody, Matthew J; Sargent, Michelle A; Michael, Demetria M; Molkentin, Jeffery D (2015. ) Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.PloS one, , 10 (6 ) ,e0130520 More Information

Accornero, Federica; van Berlo, Jop H; Correll, Robert N; Elrod, John W; Sargent, Michelle A; York, Allen; Rabinowitz, Joseph E; Leask, Andrew; Molkentin, Jeffery D (2015. ) Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor ? Signaling and Cardiac Remodeling.Molecular and cellular biology, , 35 (12 ) ,2154-64 More Information

Karch, Jason; Molkentin, Jeffery D (2015. ) Regulated necrotic cell death: the passive aggressive side of Bax and Bak.Circulation research, , 116 (11 ) ,1800-9 More Information

Mázala, Davi A G; Pratt, Stephen J P; Chen, Dapeng; Molkentin, Jeffery D; Lovering, Richard M; Chin, Eva R (2015. ) SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.American journal of physiology. Cell physiology, , 308 (9 ) ,C699-709 More Information

Sopariwala, Danesh H; Pant, Meghna; Shaikh, Sana A; Goonasekera, Sanjeewa A; Molkentin, Jeffery D; Weisleder, Noah; Ma, Jianjie; Pan, Zui; Periasamy, Muthu (2015. ) Sarcolipin overexpression improves muscle energetics and reduces fatigue.Journal of applied physiology (Bethesda, Md. : 1985), , 118 (8 ) ,1050-8 More Information

Kwong, Jennifer Q; Molkentin, Jeffery D (2015. ) Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.Cell metabolism, , 21 (2 ) ,206-214 More Information

Accornero, Federica; Kanisicak, Onur; Tjondrokoesoemo, Andoria; Attia, Aria C; McNally, Elizabeth M; Molkentin, Jeffery D (2014. ) Myofiber-specific inhibition of TGF? signaling protects skeletal muscle from injury and dystrophic disease in mice.Human molecular genetics, , 23 (25 ) ,6903-15 More Information

Goldstein, Jeffery A; Bogdanovich, Sasha; Beiriger, Anastasia; Wren, Lisa M; Rossi, Ann E; Gao, Quan Q; Gardner, Brandon B; Earley, Judy U; Molkentin, Jeffery D; McNally, Elizabeth M (2014. ) Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.Human molecular genetics, , 23 (25 ) ,6722-31 More Information

Li, Lei; Chen, Yi; Doan, Jessica; Murray, Jason; Molkentin, Jeffery D; Liu, Qinghang (2014. ) Transforming growth factor ?-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling.Circulation, , 130 (24 ) ,2162-72 More Information

Khatlani, T; Pradhan, S; Da, Q; Gushiken, F C; Bergeron, A L; Langlois, K W; Molkentin, J D; Rumbaut, R E; Vijayan, K V (2014. ) The ? isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in ?II b ?3 integrin signaling.Journal of thrombosis and haemostasis : JTH, , 12 (12 ) ,2089-101 More Information

van Berlo, Jop H; Molkentin, Jeffery D (2014. ) An emerging consensus on cardiac regeneration.Nature medicine, , 20 (12 ) ,1386-93 More Information

Ceco, Ermelinda; Bogdanovich, Sasha; Gardner, Brandon; Miller, Tamari; DeJesus, Adam; Earley, Judy U; Hadhazy, Michele; Smith, Lucas R; Barton, Elisabeth R; Molkentin, Jeffery D; McNally, Elizabeth M (2014. ) Targeting latent TGF? release in muscular dystrophy.Science translational medicine, , 6 (259 ) ,259ra144 More Information

Lauriol, Jessica; Keith, Kimberly; Jaffré, Fabrice; Couvillon, Anthony; Saci, Abdel; Goonasekera, Sanjeewa A; McCarthy, Jason R; Kessinger, Chase W; Wang, Jianxun; Ke, Qingen; Kang, Peter M; Molkentin, Jeffery D; Carpenter, Christopher; Kontaridis, Maria I (2014. ) RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.Science signaling, , 7 (348 ) ,ra100 More Information

Wissing, Erin R; Boyer, Justin G; Kwong, Jennifer Q; Sargent, Michelle A; Karch, Jason; McNally, Elizabeth M; Otsu, Kinya; Molkentin, Jeffery D (2014. ) P38? MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.Human molecular genetics, , 23 (20 ) ,5452-63 More Information

Molkentin, Jeffery D (2014. ) Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus".Circulation research, , 115 (8 ) ,e21-3 More Information

Gupta, Manish K; Gulick, James; Liu, Ruijie; Wang, Xuejun; Molkentin, Jeffery D; Robbins, Jeffrey (2014. ) Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.Circulation research, , 115 (8 ) ,721-9 More Information

Makarewich, Catherine A; Zhang, Hongyu; Davis, Jennifer; Correll, Robert N; Trappanese, Danielle M; Hoffman, Nicholas E; Troupes, Constantine D; Berretta, Remus M; Kubo, Hajime; Madesh, Muniswamy; Chen, Xiongwen; Gao, Erhe; Molkentin, Jeffery D; Houser, Steven R (2014. ) Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction.Circulation research, , 115 (6 ) ,567-580 More Information

Kwong, J Q; Davis, J; Baines, C P; Sargent, M A; Karch, J; Wang, X; Huang, T; Molkentin, J D (2014. ) Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy.Cell death and differentiation, , 21 (8 ) ,1209-17 More Information

Karch, Jason; Molkentin, Jeffery D (2014. ) Identifying the components of the elusive mitochondrial permeability transition pore.Proceedings of the National Academy of Sciences of the United States of America, , 111 (29 ) ,10396-7 More Information

Goonasekera, Sanjeewa A; Davis, Jennifer; Kwong, Jennifer Q; Accornero, Federica; Wei-LaPierre, Lan; Sargent, Michelle A; Dirksen, Robert T; Molkentin, Jeffery D (2014. ) Enhanced Ca²? influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.Human molecular genetics, , 23 (14 ) ,3706-15 More Information

Gutiérrez-Aguilar, Manuel; Douglas, Diana L; Gibson, Anne K; Domeier, Timothy L; Molkentin, Jeffery D; Baines, Christopher P (2014. ) Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.Journal of molecular and cellular cardiology, , 72 ,316-25 More Information

Tane, Shoji; Kubota, Misae; Okayama, Hitomi; Ikenishi, Aiko; Yoshitome, Satoshi; Iwamoto, Noriko; Satoh, Yukio; Kusakabe, Aoi; Ogawa, Satoko; Kanai, Ayumi; Molkentin, Jeffery D; Nakamura, Kazuomi; Ohbayashi, Tetsuya; Takeuchi, Takashi (2014. ) Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes.The Journal of biological chemistry, , 289 (26 ) ,18033-44 More Information

Burr, Adam R; Millay, Douglas P; Goonasekera, Sanjeewa A; Park, Ki Ho; Sargent, Michelle A; Collins, James; Altamirano, Francisco; Philipson, Kenneth D; Allen, Paul D; Ma, Jianjie; López, José Rafael; Molkentin, Jeffery D (2014. ) Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.Molecular and cellular biology, , 34 (11 ) ,1991-2002 More Information

van Berlo, Jop H; Kanisicak, Onur; Maillet, Marjorie; Vagnozzi, Ronald J; Karch, Jason; Lin, Suh-Chin J; Middleton, Ryan C; Marbán, Eduardo; Molkentin, Jeffery D (2014. ) c-kit+ cells minimally contribute cardiomyocytes to the heart.Nature, , 509 (7500 ) ,337-41 More Information

Davis, Jennifer; Molkentin, Jeffery D (2014. ) Myofibroblasts: trust your heart and let fate decide.Journal of molecular and cellular cardiology, , 70 ,9-18 More Information

Rainer, Peter P; Hao, Scarlett; Vanhoutte, Davy; Lee, Dong Ik; Koitabashi, Norimichi; Molkentin, Jeffery D; Kass, David A (2014. ) Cardiomyocyte-specific transforming growth factor ? suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction.Circulation research, , 114 (8 ) ,1246-57 More Information

Molkentin, Jeffery D; Houser, Steven R (2014. ) Response to Torella et al.Circulation research, , 114 (4 ) ,e27 More Information

Molkentin, Jeffrey; Williams, Ruth (2014. ) Jeffery Molkentin: delves into cell death. Interview by Ruth Williams.Circulation research, , 114 (2 ) ,239-41 More Information

Correll, Robert N; Eder, Petra; Burr, Adam R; Despa, Sanda; Davis, Jennifer; Bers, Donald M; Molkentin, Jeffery D (2014. ) Overexpression of the Na+/K+ ATPase ?2 but not ?1 isoform attenuates pathological cardiac hypertrophy and remodeling.Circulation research, , 114 (2 ) ,249-256 More Information

van Berlo, Jop H; Aronow, Bruce J; Molkentin, Jeffery D (2013. ) Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.PloS one, , 8 (12 ) ,e84591 More Information

Davis, Jennifer; Kwong, Jennifer Q; Kitsis, Richard N; Molkentin, Jeffery D (2013. ) Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.PloS one, , 8 (12 ) ,e82053 More Information

Braitsch, Caitlin M; Kanisicak, Onur; van Berlo, Jop H; Molkentin, Jeffery D; Yutzey, Katherine E (2013. ) Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease.Journal of molecular and cellular cardiology, , 65 ,108-19 More Information

Taddeo, E P; Laker, R C; Breen, D S; Akhtar, Y N; Kenwood, B M; Liao, J A; Zhang, M; Fazakerley, D J; Tomsig, J L; Harris, T E; Keller, S R; Chow, J D; Lynch, K R; Chokki, M; Molkentin, J D; Turner, N; James, D E; Yan, Z; Hoehn, K L (2014. ) Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.Molecular metabolism, , 3 (2 ) ,124-34 More Information

Molkentin, Jeffery D; Houser, Steven R (2013. ) Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart?.Circulation research, , 113 (9 ) ,1037-9 More Information

Wang, Fang; Gao, Hui; Kubo, Hajime; Fan, Xiaoxuan; Zhang, Hongyu; Berretta, Remus; Chen, Xiongwen; Sharp, Thomas; Starosta, Timothy; Makarewich, Catherine; Li, Ying; Molkentin, Jeffrey D; Houser, Steven R (2013. ) T-type Ca²? channels regulate the exit of cardiac myocytes from the cell cycle after birth.Journal of molecular and cellular cardiology, , 62 ,122-30 More Information

Karch, Jason; Kwong, Jennifer Q; Burr, Adam R; Sargent, Michelle A; Elrod, John W; Peixoto, Pablo M; Martinez-Caballero, Sonia; Osinska, Hanna; Cheng, Emily H-Y; Robbins, Jeffrey; Kinnally, Kathleen W; Molkentin, Jeffery D (2013. ) Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.eLife, , 2 ,e00772 More Information

Molkentin, Jeffery D (2013. ) Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells.Circulation research, , 113 (1 ) ,16-9 More Information

Correll, Robert N; Molkentin, Jeffery D (2013. ) CaMKII does it again: even the mitochondria cannot escape its influence.Circulation research, , 112 (9 ) ,1208-11 More Information

Molkentin, Joachim (2013. ) Applicability of organic milk indicators to the authentication of processed products.Food chemistry, , 137 (1-4 ) ,25-30 More Information

Nicholson, Chad K; Lambert, Jonathan P; Molkentin, Jeffery D; Sadoshima, Junichi; Calvert, John W (2013. ) Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.Arteriosclerosis, thrombosis, and vascular biology, , 33 (4 ) ,744-51 More Information

Suk, Hee Yun; Zhou, Chen; Yang, Teddy T C; Zhu, Hong; Yu, Raymond Y L; Olabisi, Opeyemi; Yang, XiaoYong; Brancho, Deborah; Kim, Ja-Young; Scherer, Philipp E; Frank, Philippe G; Lisanti, Michael P; Calvert, John W; Lefer, David J; Molkentin, Jeffery D; Ghigo, Alessandra; Hirsch, Emilio; Jin, Jianping; Chow, Chi-Wing (2013. ) Ablation of calcineurin A? reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.The Journal of biological chemistry, , 288 (5 ) ,3477-88 More Information

Auger-Messier, Mannix; Accornero, Federica; Goonasekera, Sanjeewa A; Bueno, Orlando F; Lorenz, John N; van Berlo, Jop H; Willette, Robert N; Molkentin, Jeffery D (2013. ) Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.Circulation research, , 112 (1 ) ,48-56 More Information

Muili, Kamaldeen A; Wang, Dong; Orabi, Abrahim I; Sarwar, Sheharyar; Luo, Yuhuan; Javed, Tanveer A; Eisses, John F; Mahmood, Syeda M; Jin, Shunqian; Singh, Vijay P; Ananthanaravanan, Meena; Perides, George; Williams, John A; Molkentin, Jeffery D; Husain, Sohail Z (2013. ) Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.The Journal of biological chemistry, , 288 (1 ) ,570-80 More Information

Elrod, John W; Molkentin, Jeffery D (2013. ) Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.Circulation journal : official journal of the Japanese Circulation Society, , 77 (5 ) ,1111-22 More Information

van Berlo, Jop H; Maillet, Marjorie; Molkentin, Jeffery D (2013. ) Signaling effectors underlying pathologic growth and remodeling of the heart.The Journal of clinical investigation, , 123 (1 ) ,37-45 More Information

Maillet, Marjorie; van Berlo, Jop H; Molkentin, Jeffery D (2013. ) Molecular basis of physiological heart growth: fundamental concepts and new players.Nature reviews. Molecular cell biology, , 14 (1 ) ,38-48 More Information

Schulz, Emily M; Correll, Richard N; Sheikh, Hajer N; Lofrano-Alves, Marco S; Engel, Patti L; Newman, Gilbert; Schultz, Jo El J; Molkentin, Jeffery D; Wolska, Beata M; Solaro, R John; Wieczorek, David F (2012. ) Tropomyosin dephosphorylation results in compensated cardiac hypertrophy.The Journal of biological chemistry, , 287 (53 ) ,44478-89 More Information

Drawnel, Faye M; Wachten, Dagmar; Molkentin, Jeffery D; Maillet, Marjorie; Aronsen, Jan Magnus; Swift, Fredrik; Sjaastad, Ivar; Liu, Ning; Catalucci, Daniele; Mikoshiba, Katsuhiko; Hisatsune, Chihiro; Okkenhaug, Hanneke; Andrews, Simon R; Bootman, Martin D; Roderick, H Llewelyn (2012. ) Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.The Journal of cell biology, , 199 (5 ) ,783-98 More Information

Gao, Hui; Wang, Fang; Wang, Wei; Makarewich, Catherine A; Zhang, Hongyu; Kubo, Hajime; Berretta, Remus M; Barr, Larry A; Molkentin, Jeffery D; Houser, Steven R (2012. ) Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling.Journal of molecular and cellular cardiology, , 53 (5 ) ,657-67 More Information

Karch, Jason; Molkentin, Jeffery D (2012. ) Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis?.Circulation research, , 111 (10 ) ,1258-60 More Information

Davis, Jennifer; Burr, Adam R; Davis, Gregory F; Birnbaumer, Lutz; Molkentin, Jeffery D (2012. ) A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo.Developmental cell, , 23 (4 ) ,705-15 More Information

Maejima, Yasuhiro; Galeotti, Jonathan; Molkentin, Jeffery D; Sadoshima, Junichi; Zhai, Peiyong (2012. ) Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3? during aging and hemodynamic pressure overload.American journal of physiology. Heart and circulatory physiology, , 303 (8 ) ,H979-88 More Information

Bal, Naresh C; Maurya, Santosh K; Sopariwala, Danesh H; Sahoo, Sanjaya K; Gupta, Subash C; Shaikh, Sana A; Pant, Meghna; Rowland, Leslie A; Bombardier, Eric; Goonasekera, Sanjeewa A; Tupling, A Russell; Molkentin, Jeffery D; Periasamy, Muthu (2012. ) Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.Nature medicine, , 18 (10 ) ,1575-9 More Information

Davis, Jennifer; Maillet, Marjorie; Miano, Joseph M; Molkentin, Jeffery D (2012. ) Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research.Circulation research, , 111 (6 ) ,761-77 More Information

Lorts, Angela; Schwanekamp, Jennifer A; Baudino, Troy A; McNally, Elizabeth M; Molkentin, Jeffery D (2012. ) Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-? pathway.Proceedings of the National Academy of Sciences of the United States of America, , 109 (27 ) ,10978-83 More Information

Houser, Steven R; Margulies, Kenneth B; Murphy, Anne M; Spinale, Francis G; Francis, Gary S; Prabhu, Sumanth D; Rockman, Howard A; Kass, David A; Molkentin, Jeffery D; Sussman, Mark A; Koch, Walter J; Koch, Walter (2012. ) Animal models of heart failure: a scientific statement from the American Heart Association.Circulation research, , 111 (1 ) ,131-50 More Information

Lynch, Jeffrey M; Maillet, Marjorie; Vanhoutte, Davy; Schloemer, Aryn; Sargent, Michelle A; Blair, N Scott; Lynch, Kaari A; Okada, Tetsuya; Aronow, Bruce J; Osinska, Hanna; Prywes, Ron; Lorenz, John N; Mori, Kazutoshi; Lawler, Jack; Robbins, Jeffrey; Molkentin, Jeffery D (2012. ) A thrombospondin-dependent pathway for a protective ER stress response.Cell, , 149 (6 ) ,1257-68 More Information

Quadrato, Giorgia; Benevento, Marco; Alber, Stefanie; Jacob, Carolin; Floriddia, Elisa M; Nguyen, Tuan; Elnaggar, Mohamed Y; Pedroarena, Christine M; Molkentin, Jeffrey D; Di Giovanni, Simone (2012. ) Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America, , 109 (23 ) ,E1499-508 More Information

Muili, Kamaldeen A; Ahmad, Mahwish; Orabi, Abrahim I; Mahmood, Syeda M; Shah, Ahsan U; Molkentin, Jeffery D; Husain, Sohail Z (2012. ) Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.American journal of physiology. Gastrointestinal and liver physiology, , 302 (8 ) ,G898-905 More Information

Liu, Qinghang; Chen, Yi; Auger-Messier, Mannix; Molkentin, Jeffery D (2012. ) Interaction between NF?B and NFAT coordinates cardiac hypertrophy and pathological remodeling.Circulation research, , 110 (8 ) ,1077-86 More Information

Makarewich, Catherine A; Correll, Robert N; Gao, Hui; Zhang, Hongyu; Yang, Baohua; Berretta, Remus M; Rizzo, Victor; Molkentin, Jeffery D; Houser, Steven R (2012. ) A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility.Circulation research, , 110 (5 ) ,669-74 More Information

Goonasekera, Sanjeewa A; Molkentin, Jeffery D (2012. ) Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte.Journal of molecular and cellular cardiology, , 52 (2 ) ,317-22 More Information

Goonasekera, Sanjeewa A; Hammer, Karin; Auger-Messier, Mannix; Bodi, Ilona; Chen, Xiongwen; Zhang, Hongyu; Reiken, Steven; Elrod, John W; Correll, Robert N; York, Allen J; Sargent, Michelle A; Hofmann, Franz; Moosmang, Sven; Marks, Andrew R; Houser, Steven R; Bers, Donald M; Molkentin, Jeffery D (2012. ) Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice.The Journal of clinical investigation, , 122 (1 ) ,280-90 More Information

Bolte, Craig; Zhang, Yufang; York, Allen; Kalin, Tanya V; Schultz, Jo El J; Molkentin, Jeffery D; Kalinichenko, Vladimir V (2012. ) Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling.PloS one, , 7 (11 ) ,e48713 More Information

Ladage, Dennis; Tilemann, Lisa; Ishikawa, Kiyotake; Correll, Robert N; Kawase, Yoshiaki; Houser, Steven R; Molkentin, Jeffery D; Hajjar, Roger J (2011. ) Inhibition of PKC?/? with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.Circulation research, , 109 (12 ) ,1396-400 More Information

Accornero, Federica; Molkentin, Jeffery D (2011. ) Placental growth factor as a protective paracrine effector in the heart.Trends in cardiovascular medicine, , 21 (8 ) ,220-4 More Information

Liu, Qinghang; Molkentin, Jeffery D (2011. ) Protein kinase C? as a heart failure therapeutic target.Journal of molecular and cellular cardiology, , 51 (4 ) ,474-8 More Information

Hom, Jennifer R; Quintanilla, Rodrigo A; Hoffman, David L; de Mesy Bentley, Karen L; Molkentin, Jeffery D; Sheu, Shey-Shing; Porter, George A (2011. ) The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation.Developmental cell, , 21 (3 ) ,469-78 More Information

Xiang, Sunny Yang; Vanhoutte, Davy; Del Re, Dominic P; Purcell, Nicole H; Ling, Haiyun; Banerjee, Indroneal; Bossuyt, Julie; Lang, Richard A; Zheng, Yi; Matkovich, Scot J; Miyamoto, Shigeki; Molkentin, Jeffery D; Dorn, Gerald W; Brown, Joan Heller (2011. ) RhoA protects the mouse heart against ischemia/reperfusion injury.The Journal of clinical investigation, , 121 (8 ) ,3269-76 More Information

van Berlo, Jop H; Elrod, John W; Aronow, Bruce J; Pu, William T; Molkentin, Jeffery D (2011. ) Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 108 (30 ) ,12331-6 More Information

Accornero, Federica; van Berlo, Jop H; Benard, Matthew J; Lorenz, John N; Carmeliet, Peter; Molkentin, Jeffery D (2011. ) Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism.Circulation research, , 109 (3 ) ,272-80 More Information

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey (2011. ) A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.Circulation research, , 109 (2 ) ,141-50 More Information

Qian, Li; Wythe, Joshua D; Liu, Jiandong; Cartry, Jerome; Vogler, Georg; Mohapatra, Bhagyalaxmi; Otway, Robyn T; Huang, Yu; King, Isabelle N; Maillet, Marjorie; Zheng, Yi; Crawley, Timothy; Taghli-Lamallem, Ouarda; Semsarian, Christopher; Dunwoodie, Sally; Winlaw, David; Harvey, Richard P; Fatkin, Diane; Towbin, Jeffrey A; Molkentin, Jeffery D; Srivastava, Deepak; Ocorr, Karen; Bruneau, Benoit G; Bodmer, Rolf (2011. ) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.The Journal of cell biology, , 193 (7 ) ,1181-96 More Information

Breitbart, Astrid; Auger-Messier, Mannix; Molkentin, Jeffery D; Heineke, Joerg (2011. ) Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting.American journal of physiology. Heart and circulatory physiology, , 300 (6 ) ,H1973-82 More Information

Yamaguchi, Naohiro; Chakraborty, Asima; Pasek, Daniel A; Molkentin, Jeffery D; Meissner, Gerhard (2011. ) Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.American journal of physiology. Heart and circulatory physiology, , 300 (6 ) ,H2187-95 More Information

Stefater, James A; Lewkowich, Ian; Rao, Sujata; Mariggi, Giovanni; Carpenter, April C; Burr, Adam R; Fan, Jieqing; Ajima, Rieko; Molkentin, Jeffery D; Williams, Bart O; Wills-Karp, Marsha; Pollard, Jeffrey W; Yamaguchi, Terry; Ferrara, Napoleone; Gerhardt, Holger; Lang, Richard A (2011. ) Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.Nature, , 474 (7352 ) ,511-5 More Information

Meissner, Marcel; Weissgerber, Petra; Londoño, Juan E Camacho; Prenen, Jean; Link, Sabine; Ruppenthal, Sandra; Molkentin, Jeffery D; Lipp, Peter; Nilius, Bernd; Freichel, Marc; Flockerzi, Veit (2011. ) Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene.The Journal of biological chemistry, , 286 (18 ) ,15875-82 More Information

Ch'en, Irene L; Tsau, Jennifer S; Molkentin, Jeffery D; Komatsu, Masaaki; Hedrick, Stephen M (2011. ) Mechanisms of necroptosis in T cells.The Journal of experimental medicine, , 208 (4 ) ,633-41 More Information

Kehat, Izhak; Accornero, Federica; Aronow, Bruce J; Molkentin, Jeffery D (2011. ) Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.The Journal of cell biology, , 193 (1 ) ,21-9 More Information

Bolli, Roberto; Stein, Adam B; Guo, Yiru; Wang, Ou-Li; Rokosh, Gregg; Dawn, Buddhadeb; Molkentin, Jeffery D; Sanganalmath, Santosh K; Zhu, Yanqing; Xuan, Yu-Ting (2011. ) A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning.Journal of molecular and cellular cardiology, , 50 (4 ) ,589-97 More Information

Sengupta, Arunima; Molkentin, Jeffery D; Paik, Ji-Hye; DePinho, Ronald A; Yutzey, Katherine E (2011. ) FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.The Journal of biological chemistry, , 286 (9 ) ,7468-78 More Information

Goonasekera, Sanjeewa A; Lam, Chi K; Millay, Douglas P; Sargent, Michelle A; Hajjar, Roger J; Kranias, Evangelia G; Molkentin, Jeffery D (2011. ) Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.The Journal of clinical investigation, , 121 (3 ) ,1044-52 More Information

Chen, Xiongwen; Nakayama, Hiroyuki; Zhang, Xiaoying; Ai, Xiaojie; Harris, David M; Tang, Mingxin; Zhang, Hongyu; Szeto, Christopher; Stockbower, Kathryn; Berretta, Remus M; Eckhart, Andrea D; Koch, Walter J; Molkentin, Jeffery D; Houser, Steven R (2011. ) Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.Journal of molecular and cellular cardiology, , 50 (3 ) ,460-70 More Information

Froese, Natali; Kattih, Badder; Breitbart, Astrid; Grund, Andrea; Geffers, Robert; Molkentin, Jeffery D; Kispert, Andreas; Wollert, Kai C; Drexler, Helmut; Heineke, Joerg (2011. ) GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling.The Journal of biological chemistry, , 286 (7 ) ,5680-90 More Information

Korf-Klingebiel, Mortimer; Kempf, Tibor; Schlüter, Klaus-Dieter; Willenbockel, Christian; Brod, Torben; Heineke, Jörg; Schmidt, Volker J; Jantzen, Franziska; Brandes, Ralf P; Sugden, Peter H; Drexler, Helmut; Molkentin, Jeffery D; Wollert, Kai C (2011. ) Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.Circulation, , 123 (5 ) ,504-14 More Information

Molkentin, Jeffery D (2011. ) The transcription factor C/EBPbeta serves as a master regulator of physiologic cardiac hypertrophy.Circulation research, , 108 (3 ) ,277-8 More Information

Sugden, Peter H; Markou, Thomais; Fuller, Stephen J; Tham, El Li; Molkentin, Jeffery D; Paterson, Hugh F; Clerk, Angela (2011. ) Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.Cellular signalling, , 23 (2 ) ,468-77 More Information

Reddy, Ramesh N; Knotts, Taylor L; Roberts, Brian R; Molkentin, Jeffery D; Price, S Russ; Gooch, Jennifer L (2011. ) Calcineurin A-? is required for hypertrophy but not matrix expansion in the diabetic kidney.Journal of cellular and molecular medicine, , 15 (2 ) ,414-22 More Information

Eder, Petra; Molkentin, Jeffery D (2011. ) TRPC channels as effectors of cardiac hypertrophy.Circulation research, , 108 (2 ) ,265-72 More Information

Kehat, Izhak; Davis, Jennifer; Tiburcy, Malte; Accornero, Federica; Saba-El-Leil, Marc K; Maillet, Marjorie; York, Allen J; Lorenz, John N; Zimmermann, Wolfram H; Meloche, Sylvain; Molkentin, Jeffery D (2011. ) Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Circulation research, , 108 (2 ) ,176-83 More Information

Wansapura, Janaka P; Millay, Douglas P; Dunn, R Scott; Molkentin, Jeffery D; Benson, D Woodrow (2011. ) Magnetic resonance imaging assessment of cardiac dysfunction in ?-sarcoglycan null mice.Neuromuscular disorders : NMD, , 21 (1 ) ,68-73 More Information

Bolte, Craig; Zhang, Yufang; Wang, I-Ching; Kalin, Tanya V; Molkentin, Jeffrey D; Kalinichenko, Vladimir V (2011. ) Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.PloS one, , 6 (7 ) ,e22217 More Information

Kehat, Izhak; Molkentin, Jeffery D (2010. ) Molecular pathways underlying cardiac remodeling during pathophysiological stimulation.Circulation, , 122 (25 ) ,2727-35 More Information

Tang, Mingxin; Li, Jie; Huang, Wei; Su, Huabo; Liang, Qiangrong; Tian, Zongwen; Horak, Kathleen M; Molkentin, Jeffery D; Wang, Xuejun (2010. ) Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts.Cardiovascular research, , 88 (3 ) ,424-33 More Information

Harper, Matthew T; Molkentin, Jeffery D; Poole, Alastair W (2010. ) Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets.Cell calcium, , 48 (6 ) ,333-40 More Information

Wissing, Erin R; Millay, Douglas P; Vuagniaux, Grégoire; Molkentin, Jeffery D (2010. ) Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice.Neuromuscular disorders : NMD, , 20 (11 ) ,753-60 More Information

van Berlo, Jop H; Elrod, John W; van den Hoogenhof, Maarten M G; York, Allen J; Aronow, Bruce J; Duncan, Stephen A; Molkentin, Jeffery D (2010. ) The transcription factor GATA-6 regulates pathological cardiac hypertrophy.Circulation research, , 107 (8 ) ,1032-40 More Information

Molkentin, Joachim; Giesemann, Anette (2010. ) Follow-up of stable isotope analysis of organic versus conventional milk.Analytical and bioanalytical chemistry, , 398 (3 ) ,1493-500 More Information

Elrod, John W; Wong, Renee; Mishra, Shikha; Vagnozzi, Ronald J; Sakthievel, Bhuvana; Goonasekera, Sanjeewa A; Karch, Jason; Gabel, Scott; Farber, John; Force, Thomas; Brown, Joan Heller; Murphy, Elizabeth; Molkentin, Jeffery D (2010. ) Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.The Journal of clinical investigation, , 120 (10 ) ,3680-7 More Information

Teekakirikul, Polakit; Eminaga, Seda; Toka, Okan; Alcalai, Ronny; Wang, Libin; Wakimoto, Hiroko; Nayor, Matthew; Konno, Tetsuo; Gorham, Joshua M; Wolf, Cordula M; Kim, Jae B; Schmitt, Joachim P; Molkentin, Jefferey D; Norris, Russell A; Tager, Andrew M; Hoffman, Stanley R; Markwald, Roger R; Seidman, Christine E; Seidman, Jonathan G (2010. ) Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-?.The Journal of clinical investigation, , 120 (10 ) ,3520-9 More Information

Zhang, Hongyu; Chen, Xiongwen; Gao, Erhe; MacDonnell, Scott M; Wang, Wei; Kolpakov, Mikhail; Nakayama, Hiroyuki; Zhang, Xiaoying; Jaleel, Naser; Harris, David M; Li, Yingxin; Tang, Mingxin; Berretta, Remus; Leri, Annarosa; Kajstura, Jan; Sabri, Abdelkarim; Koch, Walter J; Molkentin, Jeffery D; Houser, Steven R (2010. ) Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction.Circulation research, , 107 (6 ) ,800-9 More Information

Force, Thomas; Bonow, Robert O; Houser, Steven R; Solaro, R John; Hershberger, Ray E; Adhikari, Bishow; Anderson, Mark E; Boineau, Robin; Byrne, Barry J; Cappola, Thomas P; Kalluri, Raghu; LeWinter, Martin M; Maron, Martin S; Molkentin, Jeffery D; Ommen, Steve R; Regnier, Michael; Tang, W H Wilson; Tian, Rong; Konstam, Marvin A; Maron, Barry J; Seidman, Christine E (2010. ) Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.Circulation, , 122 (11 ) ,1130-3 More Information

Nakayama, Hiroyuki; Bodi, Ilona; Maillet, Marjorie; DeSantiago, Jaime; Domeier, Timothy L; Mikoshiba, Katsuhiko; Lorenz, John N; Blatter, Lothar A; Bers, Donald M; Molkentin, Jeffery D (2010. ) The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.Circulation research, , 107 (5 ) ,659-66 More Information

Sun, Tao; Wu, Xin-Sheng; Xu, Jianhua; McNeil, Benjamin D; Pang, Zhiping P; Yang, Wanjun; Bai, Li; Qadri, Syed; Molkentin, Jeffery D; Yue, David T; Wu, Ling-Gang (2010. ) The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (35 ) ,11838-47 More Information

Zhu, Hong; Suk, Hee Yun; Yu, Raymond Y L; Brancho, Deborah; Olabisi, Opeyemi; Yang, Teddy T C; Yang, XiaoYong; Zhang, Jialin; Moussaif, Mustapha; Durand, Jorge L; Jelicks, Linda A; Kim, Ja-Young; Scherer, Philipp E; Frank, Philippe G; Lisanti, Michael P; Calvert, John W; Duranski, Mark R; Lefer, David J; Huston, Elaine; Baillie, George S; Houslay, Miles D; Molkentin, Jeffrey D; Jin, Jianping; Chow, Chi-Wing (2010. ) Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.Molecular and cellular biology, , 30 (18 ) ,4379-90 More Information

Tang, Mingxin; Zhang, Xiaoying; Li, Yingxin; Guan, Yinzheng; Ai, Xiaojie; Szeto, Christopher; Nakayama, Hiroyuki; Zhang, Hongyu; Ge, Shuping; Molkentin, Jeffery D; Houser, Steven R; Chen, Xiongwen (2010. ) Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.American journal of physiology. Heart and circulatory physiology, , 299 (2 ) ,H519-28 More Information

Heineke, Joerg; Auger-Messier, Mannix; Correll, Robert N; Xu, Jian; Benard, Matthew J; Yuan, Weiping; Drexler, Helmut; Parise, Leslie V; Molkentin, Jeffery D (2010. ) CIB1 is a regulator of pathological cardiac hypertrophy.Nature medicine, , 16 (8 ) ,872-9 More Information

Andersson, Kristin B; Winer, Lisbeth H; Mørk, Halvor K; Molkentin, Jeffery D; Jaisser, Frédéric (2010. ) Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts.Transgenic research, , 19 (4 ) ,715-25 More Information

Gilio, Karen; Harper, Matthew T; Cosemans, Judith M E M; Konopatskaya, Olga; Munnix, Imke C A; Prinzen, Lenneke; Leitges, Michael; Liu, Qinghang; Molkentin, Jeffery D; Heemskerk, Johan W M; Poole, Alastair W (2010. ) Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.The Journal of biological chemistry, , 285 (30 ) ,23410-9 More Information

Marber, Michael S; Molkentin, Jeffery D; Force, Thomas (2010. ) Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point.Drug discovery today. Disease mechanisms, , 7 (2 ) ,e123-e127 More Information

Rinne, Andreas; Kapur, Nidhi; Molkentin, Jeffery D; Pogwizd, Steven M; Bers, Donald M; Banach, Kathrin; Blatter, Lothar A (2010. ) Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure.American journal of physiology. Heart and circulatory physiology, , 298 (6 ) ,H2001-9 More Information

Quinsay, Melissa N; Lee, Youngil; Rikka, Shivaji; Sayen, M Richard; Molkentin, Jeffery D; Gottlieb, Roberta A; Gustafsson, Asa B (2010. ) Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism.Journal of molecular and cellular cardiology, , 48 (6 ) ,1146-56 More Information

Heineke, Joerg; Wollert, Kai C; Osinska, Hanna; Sargent, Michelle A; York, Allen J; Robbins, Jeffrey; Molkentin, Jeffery D (2010. ) Calcineurin protects the heart in a murine model of dilated cardiomyopathy.Journal of molecular and cellular cardiology, , 48 (6 ) ,1080-7 More Information

Kitsis, Richard N; Molkentin, Jeffery D (2010. ) Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway.Proceedings of the National Academy of Sciences of the United States of America, , 107 (20 ) ,9031-2 More Information

Tsika, Richard W; Ma, Lixin; Kehat, Izhak; Schramm, Christine; Simmer, Gretchen; Morgan, Brandon; Fine, Deborah M; Hanft, Laurin M; McDonald, Kerry S; Molkentin, Jeffery D; Krenz, Maike; Yang, Steve; Ji, Juan (2010. ) TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.The Journal of biological chemistry, , 285 (18 ) ,13721-35 More Information

Wu, Xu; Eder, Petra; Chang, Baojun; Molkentin, Jeffery D (2010. ) TRPC channels are necessary mediators of pathologic cardiac hypertrophy.Proceedings of the National Academy of Sciences of the United States of America, , 107 (15 ) ,7000-5 More Information

Navedo, Manuel F; Cheng, Edward P; Yuan, Can; Votaw, Scott; Molkentin, Jeffery D; Scott, John D; Santana, Luis F (2010. ) Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.Circulation research, , 106 (4 ) ,748-56 More Information

Maillet, Marjorie; Davis, Jennifer; Auger-Messier, Mannix; York, Allen; Osinska, Hanna; Piquereau, Jérôme; Lorenz, John N; Robbins, Jeffrey; Ventura-Clapier, Renée; Molkentin, Jeffery D (2010. ) Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.The Journal of biological chemistry, , 285 (9 ) ,6716-24 More Information

Navedo, Manuel F; Takeda, Yukari; Nieves-Cintrón, Madeline; Molkentin, Jeffery D; Santana, Luis F (2010. ) Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells.American journal of physiology. Cell physiology, , 298 (2 ) ,C211-20 More Information

Kehat, Izhak; Molkentin, Jeffery D (2010. ) Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy.Annals of the New York Academy of Sciences, , 1188 ,96-102 More Information

Heineke, Joerg; Auger-Messier, Mannix; Xu, Jian; Sargent, Michelle; York, Allen; Welle, Stephen; Molkentin, Jeffery D (2010. ) Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure.Circulation, , 121 (3 ) ,419-25 More Information

Dzau, Victor J; Molkentin, Jeffery D (2009. ) Helmut Drexler, MD, 1951-2009.Circulation, , 120 (23 ) ,2402-3 More Information

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G (2009. ) Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.Circulation research, , 105 (12 ) ,1223-31 More Information

Bommireddy, R; Bueno, O F; Martin, J; Ormsby, I; Chen, H; Gard, C; Molkentin, J D; Boivin, G P; Babcock, G F; Doetschman, T (2009. ) Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.Clinical and experimental immunology, , 158 (3 ) ,317-24 More Information

Nakayama, Hiroyuki; Bodi, Ilona; Correll, Robert N; Chen, Xiongwen; Lorenz, John; Houser, Steven R; Robbins, Jeffrey; Schwartz, Arnold; Molkentin, Jeffery D (2009. ) alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice.The Journal of clinical investigation, , 119 (12 ) ,3787-96 More Information

Liu, Qinghang; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D (2009. ) ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice.Circulation research, , 105 (11 ) ,1110-7 More Information

Millay, Douglas P; Goonasekera, Sanjeewa A; Sargent, Michelle A; Maillet, Marjorie; Aronow, Bruce J; Molkentin, Jeffery D (2009. ) Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America, , 106 (45 ) ,19023-8 More Information

Tkatchenko, Tatiana V; Moreno-Rodriguez, Ricardo A; Conway, Simon J; Molkentin, Jeffery D; Markwald, Roger R; Tkatchenko, Andrei V (2009. ) Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.Physiological genomics, , 39 (3 ) ,160-8 More Information

Millay, Douglas P; Maillet, Marjorie; Roche, Joseph A; Sargent, Michelle A; McNally, Elizabeth M; Bloch, Robert J; Molkentin, Jeffery D (2009. ) Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.The American journal of pathology, , 175 (5 ) ,1817-23 More Information

Gelpi, Ricardo J; Gao, Shumin; Zhai, Peiyong; Yan, Lin; Hong, Chull; Danridge, Lauren M A; Ge, Hui; Maejima, Yasahiro; Donato, Martin; Yokota, Mitsuhiro; Molkentin, Jeffery D; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi (2009. ) Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.American journal of physiology. Heart and circulatory physiology, , 297 (5 ) ,H1814-9 More Information

Sengupta, Arunima; Molkentin, Jeffery D; Yutzey, Katherine E (2009. ) FoxO transcription factors promote autophagy in cardiomyocytes.The Journal of biological chemistry, , 284 (41 ) ,28319-31 More Information

Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D (2009. ) Cdc42 is an antihypertrophic molecular switch in the mouse heart.The Journal of clinical investigation, , 119 (10 ) ,3079-88 More Information

MacDonnell, Scott M; Weisser-Thomas, Jutta; Kubo, Hajime; Hanscome, Marie; Liu, Qinghang; Jaleel, Naser; Berretta, Remus; Chen, Xiongwen; Brown, Joan H; Sabri, Abdel-Karim; Molkentin, Jeffery D; Houser, Steven R (2009. ) CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.Circulation research, , 105 (4 ) ,316-25 More Information

Martin, Lee J; Gertz, Barry; Pan, Yan; Price, Ann C; Molkentin, Jeffery D; Chang, Qing (2009. ) The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.Experimental neurology, , 218 (2 ) ,333-46 More Information

Andersson, Kristin Brevik; Birkeland, Jon Arne Kro; Finsen, Alexandra Vanessa; Louch, William E; Sjaastad, Ivar; Wang, Yibin; Chen, Ju; Molkentin, Jeffery D; Chien, Kenneth R; Sejersted, Ole M; Christensen, Geir (2009. ) Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.Journal of molecular and cellular cardiology, , 47 (2 ) ,180-7 More Information

Liu, Qinghang; Chen, Xiongwen; Macdonnell, Scott M; Kranias, Evangelia G; Lorenz, John N; Leitges, Michael; Houser, Steven R; Molkentin, Jeffery D (2009. ) Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.Circulation research, , 105 (2 ) ,194-200 More Information

Baines, Christopher P; Molkentin, Jeffery D (2009. ) Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.Journal of molecular and cellular cardiology, , 46 (6 ) ,969-77 More Information

Ito, Kaoru; Akazawa, Hiroshi; Tamagawa, Masaji; Furukawa, Kensuke; Ogawa, Wataru; Yasuda, Noritaka; Kudo, Yoko; Liao, Chien-hui; Yamamoto, Rie; Sato, Toshiaki; Molkentin, Jeffery D; Kasuga, Masato; Noda, Tetsuo; Nakaya, Haruaki; Komuro, Issei (2009. ) PDK1 coordinates survival pathways and beta-adrenergic response in the heart.Proceedings of the National Academy of Sciences of the United States of America, , 106 (21 ) ,8689-94 More Information

Wu, Xu; Chang, Baojun; Blair, N Scott; Sargent, Michelle; York, Allen J; Robbins, Jeffrey; Shull, Gary E; Molkentin, Jeffery D (2009. ) Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.The Journal of clinical investigation, , 119 (4 ) ,976-85 More Information

Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey (2009. ) Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.Circulation, , 119 (9 ) ,1253-62 More Information

Carneiro, Leticia A M; Travassos, Leonardo H; Soares, Fraser; Tattoli, Ivan; Magalhaes, Joao G; Bozza, Marcelo T; Plotkowski, Maria C; Sansonetti, Philippe J; Molkentin, Jeffery D; Philpott, Dana J; Girardin, Stephen E (2009. ) Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.Cell host & microbe, , 5 (2 ) ,123-36 More Information

Molkentin, Joachim (2009. ) Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat.Journal of agricultural and food chemistry, , 57 (3 ) ,785-90 More Information

Hsu, Steven; Nagayama, Takahiro; Koitabashi, Norimichi; Zhang, Manling; Zhou, Liye; Bedja, Djahida; Gabrielson, Kathleen L; Molkentin, Jeffery D; Kass, David A; Takimoto, Eiki (2009. ) Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.Cardiovascular research, , 81 (2 ) ,301-9 More Information

Konopatskaya, Olga; Gilio, Karen; Harper, Matthew T; Zhao, Yan; Cosemans, Judith M E M; Karim, Zubair A; Whiteheart, Sidney W; Molkentin, Jeffery D; Verkade, Paul; Watson, Steve P; Heemskerk, Johan W M; Poole, Alastair W (2009. ) PKCalpha regulates platelet granule secretion and thrombus formation in mice.The Journal of clinical investigation, , 119 (2 ) ,399-407 More Information

Molkentin, Jeffery D; Robbins, Jeffrey (2009. ) With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure.Journal of molecular and cellular cardiology, , 46 (2 ) ,130-6 More Information

Liu, Qinghang; Busby, Jennifer Caldwell; Molkentin, Jeffery D (2009. ) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.Nature cell biology, , 11 (2 ) ,154-61 More Information

Donaldson, Cameron; Eder, Sarah; Baker, Corey; Aronovitz, Mark J; Weiss, Alexandra Dabreo; Hall-Porter, Monica; Wang, Feng; Ackerman, Adam; Karas, Richard H; Molkentin, Jeffery D; Patten, Richard D (2009. ) Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.Circulation research, , 104 (2 ) ,265-75, 11p followin More Information

Yang, Yong Jun; Chen, Wei; Edgar, Alexander; Li, Bo; Molkentin, Jeffery D; Berman, Jason N; Lin, Tong-Jun (2009. ) Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.The Journal of experimental medicine, , 206 (1 ) ,195-207 More Information

Lorts, Angela; Schwanekamp, Jennifer A; Elrod, John W; Sargent, Michelle A; Molkentin, Jeffery D (2009. ) Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair.Circulation research, , 104 (1 ) ,e1-7 More Information

Diwan, Abhinav; Matkovich, Scot J; Yuan, Qunying; Zhao, Wen; Yatani, Atsuko; Brown, Joan Heller; Molkentin, Jeffery D; Kranias, Evangelia G; Dorn, Gerald W (2009. ) Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.The Journal of clinical investigation, , 119 (1 ) ,203-12 More Information

Krenz, Maike; Gulick, James; Osinska, Hanna E; Colbert, Melissa C; Molkentin, Jeffery D; Robbins, Jeffrey (2008. ) Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.Proceedings of the National Academy of Sciences of the United States of America, , 105 (48 ) ,18930-5 More Information

Conway, Simon J; Molkentin, Jeffery D (2008. ) Periostin as a heterofunctional regulator of cardiac development and disease.Current genomics, , 9 (8 ) ,548-55 More Information

Jaleel, Naser; Nakayama, Hiroyuki; Chen, Xiongwen; Kubo, Hajime; MacDonnell, Scott; Zhang, Hongyu; Berretta, Remus; Robbins, Jeffrey; Cribbs, Leanne; Molkentin, Jeffery D; Houser, Steven R (2008. ) Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.Circulation research, , 103 (10 ) ,1109-19 More Information

Maillet, Marjorie; Purcell, Nicole H; Sargent, Michelle A; York, Allen J; Bueno, Orlando F; Molkentin, Jeffery D (2008. ) DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.The Journal of biological chemistry, , 283 (45 ) ,31246-55 More Information

da Costa Martins, Paula A; Bourajjaj, Meriem; Gladka, Monika; Kortland, Mara; van Oort, Ralph J; Pinto, Yigal M; Molkentin, Jeffery D; De Windt, Leon J (2008. ) Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling.Circulation, , 118 (15 ) ,1567-76 More Information

Nieves-Cintrón, Madeline; Amberg, Gregory C; Navedo, Manuel F; Molkentin, Jeffery D; Santana, Luis F (2008. ) The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.Proceedings of the National Academy of Sciences of the United States of America, , 105 (40 ) ,15623-8 More Information

Ramesh, Sneha; Qi, Xiao-Jun; Wildey, Gary M; Robinson, Janet; Molkentin, Jeffery; Letterio, John; Howe, Philip H (2008. ) TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2.EMBO reports, , 9 (10 ) ,990-7 More Information

Du, Heng; Guo, Lan; Fang, Fang; Chen, Doris; Sosunov, Alexander A; McKhann, Guy M; Yan, Yilin; Wang, Chunyu; Zhang, Hong; Molkentin, Jeffery D; Gunn-Moore, Frank J; Vonsattel, Jean Paul; Arancio, Ottavio; Chen, John Xi; Yan, Shi Du (2008. ) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.Nature medicine, , 14 (10 ) ,1097-105 More Information

Fuller, Stephen J; Pikkarainen, Sampsa; Tham, El Li; Cullingford, Timothy E; Molkentin, Jeffery D; Cornils, Hauke; Hergovich, Alexander; Hemmings, Brian A; Clerk, Angela; Sugden, Peter H (2008. ) Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.Cellular signalling, , 20 (8 ) ,1564-77 More Information

Blanchard, C; Mingler, M K; McBride, M; Putnam, P E; Collins, M H; Chang, G; Stringer, K; Abonia, J P; Molkentin, J D; Rothenberg, M E (2008. ) Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses.Mucosal immunology, , 1 (4 ) ,289-96 More Information

Houser, Steven R; Molkentin, Jeffery D (2008. ) Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?.Science signaling, , 1 (25 ) ,pe31 More Information

Ago, Tetsuro; Liu, Tong; Zhai, Peiyong; Chen, Wei; Li, Hong; Molkentin, Jeffery D; Vatner, Stephen F; Sadoshima, Junichi (2008. ) A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.Cell, , 133 (6 ) ,978-93 More Information

Snider, Paige; Hinton, Robert B; Moreno-Rodriguez, Ricardo A; Wang, Jian; Rogers, Rhonda; Lindsley, Andrew; Li, Fang; Ingram, David A; Menick, Donald; Field, Loren; Firulli, Anthony B; Molkentin, Jeffery D; Markwald, Roger; Conway, Simon J (2008. ) Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.Circulation research, , 102 (7 ) ,752-60 More Information

Millay, Douglas P; Sargent, Michelle A; Osinska, Hanna; Baines, Christopher P; Barton, Elisabeth R; Vuagniaux, Grégoire; Sweeney, H Lee; Robbins, Jeffrey; Molkentin, Jeffery D (2008. ) Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.Nature medicine, , 14 (4 ) ,442-7 More Information

Sahin, Bogachan; Hawasli, Ammar H; Greene, Robert W; Molkentin, Jeffery D; Bibb, James A (2008. ) Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.European journal of pharmacology, , 581 (3 ) ,270-5 More Information

Pinz, Ilka; Ostroy, Sanford E; Hoyer, Kirsten; Osinska, Hanna; Robbins, Jeffrey; Molkentin, Jeffery D; Ingwall, Joanne S (2008. ) Calcineurin-induced energy wasting in a transgenic mouse model of heart failure.American journal of physiology. Heart and circulatory physiology, , 294 (3 ) ,H1459-66 More Information

Jobe, Shawn M; Wilson, Katina M; Leo, Lorie; Raimondi, Alejandro; Molkentin, Jeffery D; Lentz, Steven R; Di Paola, Jorge (2008. ) Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis.Blood, , 111 (3 ) ,1257-65 More Information

Morancho, Beatriz; Minguillón, Jordi; Molkentin, Jeffery D; López-Rodríguez, Cristina; Aramburu, Jose (2008. ) Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.BMC molecular biology, , 9 ,13 More Information

Manicassamy, Santhakumar; Gupta, Sonal; Huang, Zhaofeng; Molkentin, Jeffery D; Shang, Weirong; Sun, Zuoming (2008. ) Requirement of calcineurin a beta for the survival of naive T cells.Journal of immunology (Baltimore, Md. : 1950), , 180 (1 ) ,106-12 More Information

Gurda, Grzegorz T; Guo, LiLi; Lee, Sae-Hong; Molkentin, Jeffery D; Williams, John A (2008. ) Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo.Molecular biology of the cell, , 19 (1 ) ,198-206 More Information

Hambleton, Michael; York, Allen; Sargent, Michelle A; Kaiser, Robert A; Lorenz, John N; Robbins, Jeffrey; Molkentin, Jeffery D (2007. ) Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.American journal of physiology. Heart and circulatory physiology, , 293 (6 ) ,H3768-71 More Information

Heineke, Joerg; Auger-Messier, Mannix; Xu, Jian; Oka, Toru; Sargent, Michelle A; York, Allen; Klevitsky, Raisa; Vaikunth, Sachin; Duncan, Stephen A; Aronow, Bruce J; Robbins, Jeffrey; Crombleholme, Timothy M; Cromblehol, Timothy M; Molkentin, Jeffery D (2007. ) Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.The Journal of clinical investigation, , 117 (11 ) ,3198-210 More Information

Davies, Kelvin J A; Ermak, Gennady; Rothermel, Beverley A; Pritchard, Melanie; Heitman, Joseph; Ahnn, Joohong; Henrique-Silva, Flavio; Crawford, Dana; Canaider, Silvia; Strippoli, Pierluigi; Carinci, Paolo; Min, Kyung-Tai; Fox, Deborah S; Cunningham, Kyle W; Bassel-Duby, Rhonda; Olson, Eric N; Zhang, Zhuohua; Williams, R Sanders; Gerber, Hans-Peter; Pérez-Riba, Mercè; Seo, Hisao; Cao, Xia; Klee, Claude B; Redondo, Juan Miguel; Maltais, Lois J; Bruford, Elspeth A; Povey, Sue; Molkentin, Jeffery D; McKeon, Frank D; Duh, Elia J; Crabtree, Gerald R; Cyert, Martha S; de la Luna, Susana; Estivill, Xavier (2007. ) Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 21 (12 ) ,3023-8 More Information

Nakayama, Hiroyuki; Chen, Xiongwen; Baines, Christopher P; Klevitsky, Raisa; Zhang, Xiaoying; Zhang, Hongyu; Jaleel, Naser; Chua, Balvin H L; Hewett, Timothy E; Robbins, Jeffrey; Houser, Steven R; Molkentin, Jeffery D (2007. ) Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.The Journal of clinical investigation, , 117 (9 ) ,2431-44 More Information

Purcell, Nicole H; Wilkins, Benjamin J; York, Allen; Saba-El-Leil, Marc K; Meloche, Sylvain; Robbins, Jeffrey; Molkentin, Jeffery D (2007. ) Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 104 (35 ) ,14074-9 More Information

Oka, Toru; Xu, Jian; Kaiser, Robert A; Melendez, Jaime; Hambleton, Michael; Sargent, Michelle A; Lorts, Angela; Brunskill, Eric W; Dorn, Gerald W; Conway, Simon J; Aronow, Bruce J; Robbins, Jeffrey; Molkentin, Jeffery D (2007. ) Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.Circulation research, , 101 (3 ) ,313-21 More Information

Nakamura, Tomoki; Colbert, Melissa; Krenz, Maike; Molkentin, Jeffery D; Hahn, Harvey S; Dorn, Gerald W; Robbins, Jeffrey (2007. ) Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.The Journal of clinical investigation, , 117 (8 ) ,2123-32 More Information

Hsieh, Patrick C H; Segers, Vincent F M; Davis, Michael E; MacGillivray, Catherine; Gannon, Joseph; Molkentin, Jeffery D; Robbins, Jeffrey; Lee, Richard T (2007. ) Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury.Nature medicine, , 13 (8 ) ,970-4 More Information

Norris, Russell A; Damon, Brook; Mironov, Vladimir; Kasyanov, Vladimir; Ramamurthi, Anand; Moreno-Rodriguez, Ricardo; Trusk, Thomas; Potts, Jay D; Goodwin, Richard L; Davis, Jeff; Hoffman, Stanley; Wen, Xuejun; Sugi, Yukiko; Kern, Christine B; Mjaatvedt, Corey H; Turner, Debi K; Oka, Toru; Conway, Simon J; Molkentin, Jeffery D; Forgacs, Gabor; Markwald, Roger R (2007. ) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues.Journal of cellular biochemistry, , 101 (3 ) ,695-711 More Information

Molkentin, Joachim; Giesemann, Anette (2007. ) Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis.Analytical and bioanalytical chemistry, , 388 (1 ) ,297-305 More Information

Baines, Christopher P; Kaiser, Robert A; Sheiko, Tatiana; Craigen, William J; Molkentin, Jeffery D (2007. ) Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.Nature cell biology, , 9 (5 ) ,550-5 More Information

Diwan, Abhinav; Koesters, Andrew G; Odley, Amy M; Pushkaran, Suvarnamala; Baines, Christopher P; Spike, Benjamin T; Daria, Diedre; Jegga, Anil G; Geiger, Hartmut; Aronow, Bruce J; Molkentin, Jeffery D; Macleod, Kay F; Kalfa, Theodosia A; Dorn, Gerald W (2007. ) Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.Proceedings of the National Academy of Sciences of the United States of America, , 104 (16 ) ,6794-9 More Information

Parsons, Stephanie A; Millay, Douglas P; Sargent, Michelle A; Naya, Francisco J; McNally, Elizabeth M; Sweeney, H Lee; Molkentin, Jeffery D (2007. ) Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy.The Journal of biological chemistry, , 282 (13 ) ,10068-78 More Information

Sano, Masanori; Minamino, Tohru; Toko, Haruhiro; Miyauchi, Hideyuki; Orimo, Masayuki; Qin, Yingjie; Akazawa, Hiroshi; Tateno, Kaoru; Kayama, Yosuke; Harada, Mutsuo; Shimizu, Ippei; Asahara, Takayuki; Hamada, Hirofumi; Tomita, Shuhei; Molkentin, Jeffrey D; Zou, Yunzeng; Komuro, Issei (2007. ) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.Nature, , 446 (7134 ) ,444-8 More Information

Nilsson, Lisa M; Sun, Zheng-Wu; Nilsson, Jenny; Nordström, Ina; Chen, Yung-Wu; Molkentin, Jeffery D; Wide-Swensson, Dag; Hellstrand, Per; Lydrup, Marie-Louise; Gomez, Maria F (2007. ) Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.American journal of physiology. Cell physiology, , 292 (3 ) ,C1167-78 More Information

Amberg, Gregory C; Navedo, Manuel F; Nieves-Cintrón, Madeline; Molkentin, Jeffery D; Santana, Luis F (2007. ) Calcium sparklets regulate local and global calcium in murine arterial smooth muscle.The Journal of physiology, , 579 (Pt 1 ) ,187-201 More Information

Peng, Jun; Raddatz, Katy; Molkentin, Jeffery D; Wu, Yiming; Labeit, Siegfried; Granzier, Henk; Gotthardt, Michael (2007. ) Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.Circulation, , 115 (6 ) ,743-51 More Information

Nieves-Cintrón, Madeline; Amberg, Gregory C; Nichols, C Blake; Molkentin, Jeffery D; Santana, Luis F (2007. ) Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension.The Journal of biological chemistry, , 282 (5 ) ,3231-40 More Information

Oka, Toru; Xu, Jian; Molkentin, Jeffery D (2007. ) Re-employment of developmental transcription factors in adult heart disease.Seminars in cell & developmental biology, , 18 (1 ) ,117-31 More Information

Xiong, Dingding; Yajima, Toshitaka; Lim, Byung-Kwan; Stenbit, Antine; Dublin, Andrew; Dalton, Nancy D; Summers-Torres, Daphne; Molkentin, Jeffery D; Duplain, Herve; Wessely, Rainer; Chen, Ju; Knowlton, Kirk U (2007. ) Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.Circulation, , 115 (1 ) ,94-102 More Information

Gong, Nanling; Bodi, Ilona; Zobel, Carsten; Schwartz, Arnold; Molkentin, Jeffery D; Backx, Peter H (2006. ) Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits.The Journal of biological chemistry, , 281 (50 ) ,38498-506 More Information

Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2006. ) Cardiac myosin binding protein C phosphorylation is cardioprotective.Proceedings of the National Academy of Sciences of the United States of America, , 103 (45 ) ,16918-23 More Information

Noh, Hye-Lim; Okajima, Kazue; Molkentin, Jeffery D; Homma, Shunichi; Homma, Sunichi; Goldberg, Ira J (2006. ) Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction.American journal of physiology. Endocrinology and metabolism, , 291 (4 ) ,E755-60 More Information

Obasanjo-Blackshire, Kofo; Mesquita, Rui; Jabr, Rita I; Molkentin, Jeffery D; Hart, Stephen L; Marber, Michael S; Xia, Yang; Heads, Richard J (2006. ) Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase.Cardiovascular research, , 71 (4 ) ,672-83 More Information

Sahin, Bogachan; Shu, Hongjun; Fernandez, Joseph; El-Armouche, Ali; Molkentin, Jeffery D; Nairn, Angus C; Bibb, James A (2006. ) Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.The Journal of biological chemistry, , 281 (34 ) ,24322-35 More Information

Hambleton, Michael; Hahn, Harvey; Pleger, Sven T; Kuhn, Matthew C; Klevitsky, Raisa; Carr, Andrew N; Kimball, Thomas F; Hewett, Timothy E; Dorn, Gerald W; Koch, Walter J; Molkentin, Jeffery D (2006. ) Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.Circulation, , 114 (6 ) ,574-82 More Information

Nakayama, Hiroyuki; Wilkin, Benjamin J; Bodi, Ilona; Molkentin, Jeffery D (2006. ) Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 20 (10 ) ,1660-70 More Information

Heineke, Joerg; Molkentin, Jeffery D (2006. ) Regulation of cardiac hypertrophy by intracellular signalling pathways.Nature reviews. Molecular cell biology, , 7 (8 ) ,589-600 More Information

Xin, Mei; Davis, Christopher A; Molkentin, Jeffery D; Lien, Ching-Ling; Duncan, Stephen A; Richardson, James A; Olson, Eric N (2006. ) A threshold of GATA4 and GATA6 expression is required for cardiovascular development.Proceedings of the National Academy of Sciences of the United States of America, , 103 (30 ) ,11189-94 More Information

Parsons, Stephanie A; Millay, Douglas P; Sargent, Michelle A; McNally, Elizabeth M; Molkentin, Jeffery D (2006. ) Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.The American journal of pathology, , 168 (6 ) ,1975-85 More Information

Navedo, Manuel F; Amberg, Gregory C; Nieves, Madeline; Molkentin, Jeffery D; Santana, Luis F (2006. ) Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle.The Journal of general physiology, , 127 (6 ) ,611-22 More Information

Chen, Xin; Shevtsov, Sergei P; Hsich, Eileen; Cui, Lei; Haq, Syed; Aronovitz, Mark; Kerkelä, Risto; Molkentin, Jeffery D; Liao, Ronglih; Salomon, Robert N; Patten, Richard; Force, Thomas (2006. ) The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.Molecular and cellular biology, , 26 (12 ) ,4462-73 More Information

Sanna, Bastiano; Brandt, Eric B; Kaiser, Robert A; Pfluger, Paul; Witt, Sandy A; Kimball, Thomas R; van Rooij, Eva; De Windt, Leon J; Rothenberg, Marc E; Tschop, Matthias H; Benoit, Stephen C; Molkentin, Jeffery D (2006. ) Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 103 (19 ) ,7327-32 More Information

Liu, Qinghang; Wilkins, Benjamin J; Lee, Yong J; Ichijo, Hidenori; Molkentin, Jeffery D (2006. ) Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.Molecular and cellular biology, , 26 (10 ) ,3785-97 More Information

Xu, Jian; Gong, Nanling L; Bodi, Ilona; Aronow, Bruce J; Backx, Peter H; Molkentin, Jeffery D (2006. ) Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.The Journal of biological chemistry, , 281 (14 ) ,9152-62 More Information

Nilsson, Jenny; Nilsson, Lisa M; Chen, Yung-Wu; Molkentin, Jeffery D; Erlinge, David; Gomez, Maria F (2006. ) High glucose activates nuclear factor of activated T cells in native vascular smooth muscle.Arteriosclerosis, thrombosis, and vascular biology, , 26 (4 ) ,794-800 More Information

Oka, Toru; Maillet, Marjorie; Watt, Alistair J; Schwartz, Robert J; Aronow, Bruce J; Duncan, Stephen A; Molkentin, Jeffery D (2006. ) Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.Circulation research, , 98 (6 ) ,837-45 More Information

Molkentin, Jeffery D (2006. ) Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling.The Journal of clinical investigation, , 116 (3 ) ,623-6 More Information

Zhao, Wen; Yuan, Qunying; Qian, Jiang; Waggoner, Jason R; Pathak, Anand; Chu, Guoxiang; Mitton, Bryan; Sun, Xiaoyin; Jin, Jay; Braz, Julian C; Hahn, Harvey S; Marreez, Yehia; Syed, Faisal; Pollesello, Piero; Annila, Arto; Wang, Hong-Sheng; Schultz, Jo El J; Molkentin, Jeffery D; Liggett, Stephen B; Dorn, Gerald W; Kranias, Evangelia G (2006. ) The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.Circulation, , 113 (7 ) ,995-1004 More Information

Xu, Jian; Kimball, Thomas R; Lorenz, John N; Brown, David A; Bauskin, Asne R; Klevitsky, Raisa; Hewett, Timothy E; Breit, Samuel N; Molkentin, Jeffery D (2006. ) GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.Circulation research, , 98 (3 ) ,342-50 More Information

Kempf, Tibor; Eden, Matthias; Strelau, Jens; Naguib, Marian; Willenbockel, Christian; Tongers, Jörn; Heineke, Jörg; Kotlarz, Daniel; Xu, Jian; Molkentin, Jeffery D; Niessen, Hans W; Drexler, Helmut; Wollert, Kai C (2006. ) The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury.Circulation research, , 98 (3 ) ,351-60 More Information

Kaiser, Robert A; Lyons, Jefferson M; Duffy, Jodie Y; Wagner, Connie J; McLean, Kelly M; O'Neill, Timothy P; Pearl, Jeffrey M; Molkentin, Jeffery D (2005. ) Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion.American journal of physiology. Heart and circulatory physiology, , 289 (6 ) ,H2747-51 More Information

Molkentin, Jeffery D (2005. ) Locating heart failure.Nature medicine, , 11 (12 ) ,1284-5 More Information

Parlakian, Ara; Charvet, Claude; Escoubet, Brigitte; Mericskay, Mathias; Molkentin, Jeffery D; Gary-Bobo, Guillaume; De Windt, Leon J; Ludosky, Marie-Aline; Paulin, Denise; Daegelen, Dominique; Tuil, David; Li, Zhenlin (2005. ) Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart.Circulation, , 112 (19 ) ,2930-9 More Information

Dai, Yan-Shan; Xu, Jian; Molkentin, Jeffery D (2005. ) The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.Molecular and cellular biology, , 25 (22 ) ,9936-48 More Information

Kaiser, Robert A; Liang, Qiangrong; Bueno, Orlando; Huang, Yuan; Lackey, Troy; Klevitsky, Raisa; Hewett, Timothy E; Molkentin, Jeffery D (2005. ) Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo.The Journal of biological chemistry, , 280 (38 ) ,32602-8 More Information

Li, Jifen; Patel, Vickas V; Kostetskii, Igor; Xiong, Yanming; Chu, Antony F; Jacobson, Jason T; Yu, Cindy; Morley, Gregory E; Molkentin, Jeffery D; Radice, Glenn L (2005. ) Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis.Circulation research, , 97 (5 ) ,474-81 More Information

Oka, Toru; Dai, Yan-Shan; Molkentin, Jeffery D (2005. ) Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo.Molecular and cellular biology, , 25 (15 ) ,6649-59 More Information

Lynch, Jeffrey; Guo, Lei; Gelebart, Pascal; Chilibeck, Kaari; Xu, Jian; Molkentin, Jeffery D; Agellon, Luis B; Michalak, Marek (2005. ) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade.The Journal of cell biology, , 170 (1 ) ,37-47 More Information

Pope, Samuel M; Fulkerson, Patricia C; Blanchard, Carine; Akei, Hiroko Saito; Nikolaidis, Nikolaos M; Zimmermann, Nives; Molkentin, Jeffery D; Rothenberg, Marc E (2005. ) Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.The Journal of biological chemistry, , 280 (14 ) ,13952-61 More Information

Baines, Christopher P; Kaiser, Robert A; Purcell, Nicole H; Blair, N Scott; Osinska, Hanna; Hambleton, Michael A; Brunskill, Eric W; Sayen, M Richard; Gottlieb, Roberta A; Dorn, Gerald W; Robbins, Jeffrey; Molkentin, Jeffery D (2005. ) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.Nature, , 434 (7033 ) ,658-62 More Information

Kostetskii, Igor; Li, Jifen; Xiong, Yanming; Zhou, Rong; Ferrari, Victor A; Patel, Vickas V; Molkentin, Jeffery D; Radice, Glenn L (2005. ) Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure.Circulation research, , 96 (3 ) ,346-54 More Information

Sanna, Bastiano; Bueno, Orlando F; Dai, Yan-Shan; Wilkins, Benjamin J; Molkentin, Jeffery D (2005. ) Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.Molecular and cellular biology, , 25 (3 ) ,865-78 More Information

Bell, Osnat; Gaberman, Elena; Kilav, Rachel; Levi, Ronen; Cox, Keith B; Molkentin, Jeffery D; Silver, Justin; Naveh-Many, Tally (2005. ) The protein phosphatase calcineurin determines basal parathyroid hormone gene expression.Molecular endocrinology (Baltimore, Md.), , 19 (2 ) ,516-26 More Information

Heineke, Joerg; Ruetten, Hartmut; Willenbockel, Christian; Gross, Sandra C; Naguib, Marian; Schaefer, Arnd; Kempf, Tibor; Hilfiker-Kleiner, Denise; Caroni, Pico; Kraft, Theresia; Kaiser, Robert A; Molkentin, Jeffery D; Drexler, Helmut; Wollert, Kai C (2005. ) Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.Proceedings of the National Academy of Sciences of the United States of America, , 102 (5 ) ,1655-60 More Information

Baines, Christopher P; Molkentin, Jeffery D (2005. ) STRESS signaling pathways that modulate cardiac myocyte apoptosis.Journal of molecular and cellular cardiology, , 38 (1 ) ,47-62 More Information

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying (2005. ) MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Molecular and cellular biology, , 25 (1 ) ,60-5 More Information

Nimah, Marianne; Zhao, Bin; Denenberg, Alvin G; Bueno, Orlando; Molkentin, Jeffery; Wong, Hector R; Shanley, Thomas P (2005. ) Contribution of MKP-1 regulation of p38 to endotoxin tolerance.Shock (Augusta, Ga.), , 23 (1 ) ,80-7 More Information

Moz, Yulia; Levi, Ronen; Lavi-Moshayoff, Vardit; Cox, Keith B; Molkentin, Jeffery D; Silver, Justin; Naveh-Many, Tally (2004. ) Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport.Journal of the American Society of Nephrology : JASN, , 15 (12 ) ,2972-80 More Information

Matsuura, Katsuhisa; Wada, Hiroshi; Nagai, Toshio; Iijima, Yoshihiro; Minamino, Tohru; Sano, Masanori; Akazawa, Hiroshi; Molkentin, Jeffery D; Kasanuki, Hiroshi; Komuro, Issei (2004. ) Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle.The Journal of cell biology, , 167 (2 ) ,351-63 More Information

Wilkins, Benjamin J; Molkentin, Jeffery D (2004. ) Calcium-calcineurin signaling in the regulation of cardiac hypertrophy.Biochemical and biophysical research communications, , 322 (4 ) ,1178-91 More Information

Molkentin, Jeffery D (2004. ) Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs.Cardiovascular research, , 63 (3 ) ,467-75 More Information

Parsons, Stephanie A; Millay, Douglas P; Wilkins, Benjamin J; Bueno, Orlando F; Tsika, Gretchen L; Neilson, Joel R; Liberatore, Christine M; Yutzey, Katherine E; Crabtree, Gerald R; Tsika, Richard W; Molkentin, Jeffery D (2004. ) Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.The Journal of biological chemistry, , 279 (25 ) ,26192-200 More Information

Michael, Ashour; Haq, Syed; Chen, Xin; Hsich, Eileen; Cui, Lei; Walters, Brian; Shao, Zhili; Bhattacharya, Kausik; Kilter, Heiko; Huggins, Gordon; Andreucci, Michele; Periasamy, Muthu; Solomon, Robert N; Liao, Ronglih; Patten, Richard; Molkentin, Jeffery D; Force, Thomas (2004. ) Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.The Journal of biological chemistry, , 279 (20 ) ,21383-93 More Information

Lips, Daniel J; Bueno, Orlando F; Wilkins, Benjamin J; Purcell, Nicole H; Kaiser, Robert A; Lorenz, John N; Voisin, Laure; Saba-El-Leil, Marc K; Meloche, Sylvain; Pouysségur, Jacques; Pagès, Gilles; De Windt, Leon J; Doevendans, Pieter A; Molkentin, Jeffery D (2004. ) MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.Circulation, , 109 (16 ) ,1938-41 More Information

Aliahmad, Parinaz; O'Flaherty, Emmett; Han, Peggy; Goularte, Olivia D; Wilkinson, Beverley; Satake, Masanobu; Molkentin, Jeffery D; Kaye, Jonathan (2004. ) TOX provides a link between calcineurin activation and CD8 lineage commitment.The Journal of experimental medicine, , 199 (8 ) ,1089-99 More Information

Kaiser, Robert A; Bueno, Orlando F; Lips, Daniel J; Doevendans, Pieter A; Jones, Fred; Kimball, Thomas F; Molkentin, Jeffery D (2004. ) Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.The Journal of biological chemistry, , 279 (15 ) ,15524-30 More Information

Braz, Julian C; Gregory, Kimberly; Pathak, Anand; Zhao, Wen; Sahin, Bogachan; Klevitsky, Raisa; Kimball, Thomas F; Lorenz, John N; Nairn, Angus C; Liggett, Stephen B; Bodi, Ilona; Wang, Su; Schwartz, Arnold; Lakatta, Edward G; DePaoli-Roach, Anna A; Robbins, Jeffrey; Hewett, Timothy E; Bibb, James A; Westfall, Margaret V; Kranias, Evangelia G; Molkentin, Jeffery D (2004. ) PKC-alpha regulates cardiac contractility and propensity toward heart failure.Nature medicine, , 10 (3 ) ,248-54 More Information

Lange, Alexander W; Molkentin, Jeffery D; Yutzey, Katherine E (2004. ) DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.Developmental biology, , 266 (2 ) ,346-60 More Information

Purcell, Nicole H; Darwis, Dina; Bueno, Orlando F; Müller, Judith M; Schüle, Roland; Molkentin, Jeffery D (2004. ) Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.Molecular and cellular biology, , 24 (3 ) ,1081-95 More Information

Dorn, Gerald W; Molkentin, Jeffery D (2004. ) Manipulating cardiac contractility in heart failure: data from mice and men.Circulation, , 109 (2 ) ,150-8 More Information

Wilkins, Benjamin J; Dai, Yan-Shan; Bueno, Orlando F; Parsons, Stephanie A; Xu, Jian; Plank, David M; Jones, Fred; Kimball, Thomas R; Molkentin, Jeffery D (2004. ) Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.Circulation research, , 94 (1 ) ,110-8 More Information

Bueno, Orlando F; Lips, Daniel J; Kaiser, Robert A; Wilkins, Benjamin J; Dai, Yan-Shan; Glascock, Betty J; Klevitsky, Raisa; Hewett, Timothy E; Kimball, Thomas R; Aronow, Bruce J; Doevendans, Pieter A; Molkentin, Jeffery D (2004. ) Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction.Circulation research, , 94 (1 ) ,91-9 More Information

Liang, Qiangrong; Molkentin, Jeffery D (2003. ) Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models.Journal of molecular and cellular cardiology, , 35 (12 ) ,1385-94 More Information

Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D (2003. ) c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.The EMBO journal, , 22 (19 ) ,5079-89 More Information

Prabhakar, Rethinasamy; Petrashevskaya, Natalia; Schwartz, Arnold; Aronow, Bruce; Boivin, Greg P; Molkentin, Jeffery D; Wieczorek, David F (2003. ) A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Molecular and cellular biochemistry, , 251 (1-2 ) ,33-42

Purcell, Nicole H; Molkentin, Jeffery D (2003. ) Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?.Circulation, , 108 (6 ) ,638-40 More Information

Haq, Syed; Kilter, Heiko; Michael, Ashour; Tao, Jingzang; O'Leary, Eileen; Sun, Xio Ming; Walters, Brian; Bhattacharya, Kausik; Chen, Xin; Cui, Lei; Andreucci, Michele; Rosenzweig, Anthony; Guerrero, J Luis; Patten, Richard; Liao, Ronglih; Molkentin, Jeffery; Picard, Michael; Bonventre, Joseph V; Force, Thomas (2003. ) Deletion of cytosolic phospholipase A2 promotes striated muscle growth.Nature medicine, , 9 (7 ) ,944-51 More Information

Bushdid, Paul B; Osinska, Hanna; Waclaw, Ronald R; Molkentin, Jeffery D; Yutzey, Katherine E (2003. ) NFATc3 and NFATc4 are required for cardiac development and mitochondrial function.Circulation research, , 92 (12 ) ,1305-13 More Information

Schubert, William; Yang, Xiao Yong; Yang, Teddy T C; Factor, Stephen M; Lisanti, Michael P; Molkentin, Jeffery D; Rincon, Mercedes; Chow, Chi-Wing (2003. ) Requirement of transcription factor NFAT in developing atrial myocardium.The Journal of cell biology, , 161 (5 ) ,861-74 More Information

Parsons, Stephanie A; Wilkins, Benjamin J; Bueno, Orlando F; Molkentin, Jeffery D (2003. ) Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.Molecular and cellular biology, , 23 (12 ) ,4331-43 More Information

Suzuki, Yuichiro J; Day, Regina M; Tan, Chia Chi; Sandven, Tor H; Liang, Qiangrong; Molkentin, Jeffery D; Fanburg, Barry L (2003. ) Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells.The Journal of biological chemistry, , 278 (19 ) ,17525-31 More Information

Braz, Julian C; Bueno, Orlando F; Liang, Qiangrong; Wilkins, Benjamin J; Dai, Yan-Shan; Parsons, Stephanie; Braunwart, Joseph; Glascock, Betty J; Klevitsky, Raisa; Kimball, Thomas F; Hewett, Timothy E; Molkentin, Jeffery D (2003. ) Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.The Journal of clinical investigation, , 111 (10 ) ,1475-86 More Information

Molkentin, Jeffery D (2003. ) A friend within the heart: natriuretic peptide receptor signaling.The Journal of clinical investigation, , 111 (9 ) ,1275-7 More Information

Rybin, Vitalyi O; Sabri, Abdelkarim; Short, Jacob; Braz, Julian C; Molkentin, Jeffery D; Steinberg, Susan F (2003. ) Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations.The Journal of biological chemistry, , 278 (16 ) ,14555-64 More Information

Petrich, Brian G; Molkentin, Jeffery D; Wang, Yibin (2003. ) Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 17 (6 ) ,749-51 More Information

Gajewski, Kathleen; Wang, Jianbo; Molkentin, Jeffery D; Chen, Elizabeth H; Olson, Eric N; Schulz, Robert A (2003. ) Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila.Proceedings of the National Academy of Sciences of the United States of America, , 100 (3 ) ,1040-5 More Information

Sayen, M R; Gustafsson, Asa B; Sussman, Mark A; Molkentin, Jeffery D; Gottlieb, Roberta A (2003. ) Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.American journal of physiology. Cell physiology, , 284 (2 ) ,C562-70 More Information

Semeniuk, L M; Severson, D L; Kryski, A J; Swirp, S L; Molkentin, J D; Duff, H J (2003. ) Time-dependent systolic and diastolic function in mice overexpressing calcineurin.American journal of physiology. Heart and circulatory physiology, , 284 (2 ) ,H425-30 More Information

Dong, Deli; Duan, Yanjun; Guo, Jiqing; Roach, Dan E; Swirp, Shauni L; Wang, Li; Lees-Miller, J P; Sheldon, R S; Molkentin, Jeffery D; Duff, Henry J (2003. ) Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels.Cardiovascular research, , 57 (2 ) ,320-32 More Information

van Rooij, Eva; Doevendans, Pieter A; de Theije, Chiel C; Babiker, Fawzi A; Molkentin, Jeffery D; de Windt, Leon J (2002. ) Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy.The Journal of biological chemistry, , 277 (50 ) ,48617-26 More Information

Bueno, Orlando F; Molkentin, Jeffery D (2002. ) Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death.Circulation research, , 91 (9 ) ,776-81 More Information

Tomita, Masuhiro; Reinhold, Martina I; Molkentin, Jeffery D; Naski, Michael C (2002. ) Calcineurin and NFAT4 induce chondrogenesis.The Journal of biological chemistry, , 277 (44 ) ,42214-8 More Information

Wilkins, Benjamin J; De Windt, Leon J; Bueno, Orlando F; Braz, Julian C; Glascock, Betty J; Kimball, Thomas F; Molkentin, Jeffery D (2002. ) Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.Molecular and cellular biology, , 22 (21 ) ,7603-13 More Information

Lynch, Roy A; Wagoner, Lynne; Li, Shunan; Sparks, Li; Molkentin, Jeffery; Dorn, Gerald W (2002. ) Novel and nondetected human signaling protein polymorphisms.Physiological genomics, , 10 (3 ) ,159-68 More Information

Jacob, Asha; Molkentin, Jeffery D; Smolenski, Albert; Lohmann, Suzanne M; Begum, Najma (2002. ) Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.American journal of physiology. Cell physiology, , 283 (3 ) ,C704-13 More Information

Fiedler, Beate; Lohmann, Suzanne M; Smolenski, Albert; Linnemuller, Stephan; Pieske, Burkert; Schroder, Frank; Molkentin, Jeffery D; Drexler, Helmut; Wollert, Kai C (2002. ) Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.Proceedings of the National Academy of Sciences of the United States of America, , 99 (17 ) ,11363-8 More Information

Bueno, Orlando F; Brandt, Eric B; Rothenberg, Marc E; Molkentin, Jeffery D (2002. ) Defective T cell development and function in calcineurin A beta -deficient mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (14 ) ,9398-403 More Information

Dai, Yan-Shan; Cserjesi, Peter; Markham, Bruce E; Molkentin, Jeffery D (2002. ) The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.The Journal of biological chemistry, , 277 (27 ) ,24390-8 More Information

Donelan, Matthew J; Morfini, Gerardo; Julyan, Richard; Sommers, Scott; Hays, Lori; Kajio, Hiroshi; Briaud, Isabelle; Easom, Richard A; Molkentin, Jeffery D; Brady, Scott T; Rhodes, Christopher J (2002. ) Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.The Journal of biological chemistry, , 277 (27 ) ,24232-42 More Information

Liang, Qiangrong; Molkentin, Jeffery D (2002. ) Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression.Journal of molecular and cellular cardiology, , 34 (6 ) ,611-6 More Information

Wilkins, Benjamin J; Molkentin, Jeffery D (2002. ) Calcineurin and cardiac hypertrophy: where have we been? Where are we going?.The Journal of physiology, , 541 (Pt 1 ) ,1-8 More Information

Sah, Rajan; Oudit, Gavin Y; Nguyen, The-Tin T; Lim, Hae W; Wickenden, Alan D; Wilson, Gregory J; Molkentin, Jeffery D; Backx, Peter H (2002. ) Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice.Circulation, , 105 (15 ) ,1850-6 More Information

Bueno, Orlando F; Wilkins, Benjamin J; Tymitz, Kevin M; Glascock, Betty J; Kimball, Thomas F; Lorenz, John N; Molkentin, Jeffery D (2002. ) Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (7 ) ,4586-91 More Information

Petrashevskaya, Natalia N; Bodi, Ilona; Rubio, Marta; Molkentin, Jeffery D; Schwartz, Arnold (2002. ) Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse.Cardiovascular research, , 54 (1 ) ,117-32 More Information

Chu, Guoxiang; Carr, Andrew N; Young, Karen B; Lester, J William; Yatani, Atsuko; Sanbe, Atsushi; Colbert, Melissa C; Schwartz, Steven M; Frank, Konrad F; Lampe, Paul D; Robbins, Jeffrey; Molkentin, Jeffery D; Kranias, Evangelia G (2002. ) Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.Cardiovascular research, , 54 (1 ) ,105-16 More Information

Kassiri, Zamaneh; Zobel, Carsten; Nguyen, The-Tin T; Molkentin, Jeffery D; Backx, Peter H (2002. ) Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.Circulation research, , 90 (5 ) ,578-85 More Information

Braz, Julian C; Bueno, Orlando F; De Windt, Leon J; Molkentin, Jeffery D (2002. ) PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2).The Journal of cell biology, , 156 (5 ) ,905-19 More Information

Bueno, Orlando F; van Rooij, Eva; Molkentin, Jeffery D; Doevendans, Pieter A; De Windt, Leon J (2002. ) Calcineurin and hypertrophic heart disease: novel insights and remaining questions.Cardiovascular research, , 53 (4 ) ,806-21 More Information

Liang, Q; Wiese, R J; Bueno, O F; Dai, Y S; Markham, B E; Molkentin, J D (2001. ) The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.Molecular and cellular biology, , 21 (21 ) ,7460-9 More Information

Charron, F; Tsimiklis, G; Arcand, M; Robitaille, L; Liang, Q; Molkentin, J D; Meloche, S; Nemer, M (2001. ) Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.Genes & development, , 15 (20 ) ,2702-19 More Information

Qiao, L; Studer, E; Leach, K; McKinstry, R; Gupta, S; Decker, R; Kukreja, R; Valerie, K; Nagarkatti, P; El Deiry, W; Molkentin, J; Schmidt-Ullrich, R; Fisher, P B; Grant, S; Hylemon, P B; Dent, P (2001. ) Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.Molecular biology of the cell, , 12 (9 ) ,2629-45 More Information

Liang, Q; De Windt, L J; Witt, S A; Kimball, T R; Markham, B E; Molkentin, J D (2001. ) The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.The Journal of biological chemistry, , 276 (32 ) ,30245-53 More Information

Precht, D; Molkentin, J; Destaillats, F; Wolff, R L (2001. ) Comparative studies on individual isomeric 18:1 acids in cow, goat, and ewe milk fats by low-temperature high-resolution capillary gas-liquid chromatography.Lipids, , 36 (8 ) ,827-32 More Information

Sohal, D S; Nghiem, M; Crackower, M A; Witt, S A; Kimball, T R; Tymitz, K M; Penninger, J M; Molkentin, J D (2001. ) Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein.Circulation research, , 89 (1 ) ,20-5 More Information

Molkentin, J D (2001. ) Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis.Circulation research, , 88 (12 ) ,1220-2 More Information

Aronow, B J; Toyokawa, T; Canning, A; Haghighi, K; Delling, U; Kranias, E; Molkentin, J D; Dorn, G W (2001. ) Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy.Physiological genomics, , 6 (1 ) ,19-28 More Information

Lim, H W; New, L; Han, J; Molkentin, J D (2001. ) Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.The Journal of biological chemistry, , 276 (19 ) ,15913-9 More Information

Li, J; Molkentin, J D; Colbert, M C (2001. ) Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation.Developmental biology, , 232 (2 ) ,351-61 More Information

Crispino, J D; Lodish, M B; Thurberg, B L; Litovsky, S H; Collins, T; Molkentin, J D; Orkin, S H (2001. ) Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.Genes & development, , 15 (7 ) ,839-44 More Information

De Windt, L J; Lim, H W; Bueno, O F; Liang, Q; Delling, U; Braz, J C; Glascock, B J; Kimball, T F; del Monte, F; Hajjar, R J; Molkentin, J D (2001. ) Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 98 (6 ) ,3322-7 More Information

Haq, S; Choukroun, G; Lim, H; Tymitz, K M; del Monte, F; Gwathmey, J; Grazette, L; Michael, A; Hajjar, R; Force, T; Molkentin, J D (2001. ) Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure.Circulation, , 103 (5 ) ,670-7 More Information

Yatani, A; Honda, R; Tymitz, K M; Lalli, M J; Molkentin, J D (2001. ) Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway.Journal of molecular and cellular cardiology, , 33 (2 ) ,249-59 More Information

Precht, D; Molkentin, J; McGuire, M A; McGuire, M K; Jensen, R G (2001. ) Overestimates of oleic and linoleic acid contents in materials containing trans fatty acids and analyzed with short packed gas chromatographic columns.Lipids, , 36 (2 ) ,213-6 More Information

Bueno, O F; De Windt, L J; Lim, H W; Tymitz, K M; Witt, S A; Kimball, T R; Molkentin, J D (2001. ) The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo.Circulation research, , 88 (1 ) ,88-96 More Information

Molkentin, J D; Dorn, G W (2001. ) Cytoplasmic signaling pathways that regulate cardiac hypertrophy.Annual review of physiology, , 63 ,391-426 More Information

Molkentin, J D (2000. ) The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.The Journal of biological chemistry, , 275 (50 ) ,38949-52 More Information

Bueno, O F; De Windt, L J; Tymitz, K M; Witt, S A; Kimball, T R; Klevitsky, R; Hewett, T E; Jones, S P; Lefer, D J; Peng, C F; Kitsis, R N; Molkentin, J D (2000. ) The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.The EMBO journal, , 19 (23 ) ,6341-50 More Information

Molkentin, J (2000. ) Occurrence and biochemical characteristics of natural bioactive substances in bovine milk lipids.The British journal of nutrition, , 84 Suppl 1 ,S47-53 More Information

Molkentin, J D (2000. ) Calcineurin and beyond: cardiac hypertrophic signaling.Circulation research, , 87 (9 ) ,731-8 More Information

Haq, S; Choukroun, G; Kang, Z B; Ranu, H; Matsui, T; Rosenzweig, A; Molkentin, J D; Alessandrini, A; Woodgett, J; Hajjar, R; Michael, A; Force, T (2000. ) Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy.The Journal of cell biology, , 151 (1 ) ,117-30 More Information

Destaillats, F; Wolff, R L; Precht, D; Molkentin, J (2000. ) Study of individual trans- and cis-16:1 isomers in cow, goat, and ewe cheese fats by gas-liquid chromatography with emphasis on the trans-delta3 isomer.Lipids, , 35 (9 ) ,1027-32 More Information

Delling, U; Tureckova, J; Lim, H W; De Windt, L J; Rotwein, P; Molkentin, J D (2000. ) A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.Molecular and cellular biology, , 20 (17 ) ,6600-11 More Information

Delling, U; Sussman, M A; Molkentin, J D (2000. ) Re-evaluating sarcoplasmic reticulum function in heart failure.Nature medicine, , 6 (9 ) ,942-3 More Information

Wolff, R L; Combe, N A; Destaillats, F; Boué, C; Precht, D; Molkentin, J; Entressangles, B (2000. ) Follow-up of the delta4 to delta16 trans-18:1 isomer profile and content in French processed foods containing partially hydrogenated vegetable oils during the period 1995-1999. Analytical and nutritional implications.Lipids, , 35 (8 ) ,815-25 More Information

Precht, D; Molkentin, J (2000. ) Recent trends in the fatty acid composition of German sunflower margarines, shortenings and cooking fats with emphasis on individual C16:1, C18:1, C18:2, C18:3 and C20:1 trans isomers.Die Nahrung, , 44 (4 ) ,222-8 More Information

Molkentin, J D; Tymitz, K M; Richardson, J A; Olson, E N (2000. ) Abnormalities of the genitourinary tract in female mice lacking GATA5.Molecular and cellular biology, , 20 (14 ) ,5256-60 More Information

Lim, H W; De Windt, L J; Steinberg, L; Taigen, T; Witt, S A; Kimball, T R; Molkentin, J D (2000. ) Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy.Circulation, , 101 (20 ) ,2431-7 More Information

De Windt, L J; Lim, H W; Haq, S; Force, T; Molkentin, J D (2000. ) Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways.The Journal of biological chemistry, , 275 (18 ) ,13571-9 More Information

Sussman, M A; Welch, S; Walker, A; Klevitsky, R; Hewett, T E; Witt, S A; Kimball, T R; Price, R; Lim, H W; Molkentin, J D (2000. ) Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.Cardiovascular research, , 46 (1 ) ,90-101 More Information

Lim, H W; De Windt, L J; Mante, J; Kimball, T R; Witt, S A; Sussman, M A; Molkentin, J D (2000. ) Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.Journal of molecular and cellular cardiology, , 32 (4 ) ,697-709 More Information

De Windt, L J; Lim, H W; Taigen, T; Wencker, D; Condorelli, G; Dorn, G W; Kitsis, R N; Molkentin, J D (2000. ) Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure.Circulation research, , 86 (3 ) ,255-63 More Information

Taigen, T; De Windt, L J; Lim, H W; Molkentin, J D (2000. ) Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.Proceedings of the National Academy of Sciences of the United States of America, , 97 (3 ) ,1196-201 More Information

Molkentin, J D; Antos, C; Mercer, B; Taigen, T; Miano, J M; Olson, E N (2000. ) Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.Developmental biology, , 217 (2 ) ,301-9 More Information

Lim, ; Molkentin, (2000. ) Reply to revisiting calcineurin and human heart failure.Nature medicine, , 6 (1 ) ,3 More Information

Han, J; Molkentin, J D (2000. ) Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology.Trends in cardiovascular medicine, , 10 (1 ) ,19-22 More Information

Sussman, M A; Welch, S; Gude, N; Khoury, P R; Daniels, S R; Kirkpatrick, D; Walsh, R A; Price, R L; Lim, H W; Molkentin, J D (1999. ) Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice.The American journal of pathology, , 155 (6 ) ,2101-13 More Information

Gajewski, K; Fossett, N; Molkentin, J D; Schulz, R A (1999. ) The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development (Cambridge, England), , 126 (24 ) ,5679-88

Precht, D; Molkentin, J (1999. ) C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids.Die Nahrung, , 43 (4 ) ,233-44 More Information

Molkentin, J (1999. ) Bioactive lipids naturally occurring in bovine milk.Die Nahrung, , 43 (3 ) ,185-9 More Information

Olson, E N; Molkentin, J D (1999. ) Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?.Circulation research, , 84 (6 ) ,623-32 More Information

Wilson-Rawls, J; Molkentin, J D; Black, B L; Olson, E N (1999. ) Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.Molecular and cellular biology, , 19 (4 ) ,2853-62 More Information

Lim, H W; Molkentin, J D (1999. ) Calcineurin and human heart failure.Nature medicine, , 5 (3 ) ,246-7 More Information

Sussman, M A; Lim, H W; Gude, N; Taigen, T; Olson, E N; Robbins, J; Colbert, M C; Gualberto, A; Wieczorek, D F; Molkentin, J D (1998. ) Prevention of cardiac hypertrophy in mice by calcineurin inhibition.Science (New York, N.Y.), , 281 (5383 ) ,1690-3 More Information

Molkentin, J D; Lu, J R; Antos, C L; Markham, B; Richardson, J; Robbins, J; Grant, S R; Olson, E N (1998. ) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.Cell, , 93 (2 ) ,215-28 More Information

Katoh, Y; Molkentin, J D; Dave, V; Olson, E N; Periasamy, M (1998. ) MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.The Journal of biological chemistry, , 273 (3 ) ,1511-8 More Information

Black, B L; Molkentin, J D; Olson, E N (1998. ) Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.Molecular and cellular biology, , 18 (1 ) ,69-77 More Information

Molkentin, J D; Olson, E N (1997. ) GATA4: a novel transcriptional regulator of cardiac hypertrophy? .Circulation, , 96 (11 ) ,3833-5

Precht, D; Molkentin, J (1997. ) Effect of feeding on conjugated cis delta 9, trans delta 11-octadecadienoic acid and other isomers of linoleic acid in bovine milk fats.Die Nahrung, , 41 (6 ) ,330-5 More Information

Herzig, T C; Jobe, S M; Aoki, H; Molkentin, J D; Cowley, A W; Izumo, S; Markham, B E (1997. ) Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.Proceedings of the National Academy of Sciences of the United States of America, , 94 (14 ) ,7543-8 More Information

Molkentin, J D; Lin, Q; Duncan, S A; Olson, E N (1997. ) Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.Genes & development, , 11 (8 ) ,1061-72 More Information

Molkentin, J D; Olson, E N (1996. ) Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.Proceedings of the National Academy of Sciences of the United States of America, , 93 (18 ) ,9366-73 More Information

Molkentin, J D; Olson, E N (1996. ) Defining the regulatory networks for muscle development.Current opinion in genetics & development, , 6 (4 ) ,445-53 More Information

Molkentin, J D; Li, L; Olson, E N (1996. ) Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.The Journal of biological chemistry, , 271 (29 ) ,17199-204 More Information

Molkentin, J D; Firulli, A B; Black, B L; Martin, J F; Hustad, C M; Copeland, N; Jenkins, N; Lyons, G; Olson, E N (1996. ) MEF2B is a potent transactivator expressed in early myogenic lineages.Molecular and cellular biology, , 16 (7 ) ,3814-24 More Information

Molkentin, J D; Jobe, S M; Markham, B E (1996. ) Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter.Journal of molecular and cellular cardiology, , 28 (6 ) ,1211-25 More Information

Molkentin, J D; Black, B L; Martin, J F; Olson, E N (1996. ) Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.Molecular and cellular biology, , 16 (6 ) ,2627-36 More Information

Molkentin, J D; Black, B L; Martin, J F; Olson, E N (1995. ) Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.Cell, , 83 (7 ) ,1125-36 More Information

Molkentin, J; Precht, D (1995. ) Determination of trans-octadecenoic acids in German margarines, shortenings, cooking and dietary fats by Ag-TLC/GC.Zeitschrift fur Ernahrungswissenschaft, , 34 (4 ) ,314-7 More Information

Ranganayakulu, G; Zhao, B; Dokidis, A; Molkentin, J D; Olson, E N; Schulz, R A (1995. ) A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila.Developmental biology, , 171 (1 ) ,169-81 More Information

Precht, D; Molkentin, J (1995. ) Trans fatty acids: implications for health, analytical methods, incidence in edible fats and intake (a review).Die Nahrung, , 39 (5-6 ) ,343-74 More Information

Molkentin, J D; Markham, B E (1994. ) An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo.Molecular and cellular biology, , 14 (8 ) ,5056-65 More Information

Molkentin, J D; Kalvakolanu, D V; Markham, B E (1994. ) Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.Molecular and cellular biology, , 14 (7 ) ,4947-57 More Information

Molkentin, J D; Markham, B E (1993. ) Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo. The Journal of biological chemistry, , 268 (26 ) ,19512-20

Molkentin, J; Gregersen, P K; Lin, X; Zhu, N; Wang, Y; Wang, Y; Chen, S; Chen, S; Baxter-Lowe, L A; Silver, J (1993. ) Molecular analysis of HLA-DR beta and DQ beta polymorphism in Chinese with rheumatoid arthritis.Annals of the rheumatic diseases, , 52 (8 ) ,610-2 More Information

Dahms, N M; Rose, P A; Molkentin, J D; Zhang, Y; Brzycki, M A (1993. ) The bovine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. The Journal of biological chemistry, , 268 (8 ) ,5457-63

Molkentin, J D; Brogan, R S; Jobe, S M; Markham, B E (1993. ) Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism. The Journal of biological chemistry, , 268 (4 ) ,2602-9

Barbieri, J T; Armellini, D; Molkentin, J; Rappuoli, R (1992. ) Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. Infection and immunity, , 60 (12 ) ,5071-7

Molkentin, J; Gorski, J; Baxter-Lowe, L A (1991. ) Detection of 14 HLA-DQB1 alleles by oligotyping.Human immunology, , 31 (2 ) ,114-22 More Information

Contact Information

jeff.molkentin@cchmc.org

Academic - Cincinnati Children's Hospital Medical Center
240 Albert Sabin Way, MLC7020
Cincinnati  Ohio, 45229
Phone: 513-636-3557
Fax: 513-636-5958
jeff.molkentin@cchmc.org