James Mulloy, Ph.D. , PhD

Peer Reviewed Publications

Wunderlich, Mark; Brooks, Ryan A; Panchal, Rushi; Rhyasen, Garrett W; Danet-Desnoyers, Gwenn; Mulloy, James C (2014. ) OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.Blood, , 123 (24 ) ,e134-44 More Information

Kong, Guangyao; Wunderlich, Mark; Yang, David; Ranheim, Erik A; Young, Ken H; Wang, Jinyong; Chang, Yuan-I; Du, Juan; Liu, Yangang; Tey, Sin Ruow; Zhang, Xinmin; Juckett, Mark; Mattison, Ryan; Damnernsawad, Alisa; Zhang, Jingfang; Mulloy, James C; Zhang, Jing (2014. ) Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.The Journal of clinical investigation, , 124 (6 ) ,2762-73 More Information

Zhao, Xinghui; Chen, Aili; Yan, Xiaomei; Zhang, Yue; He, Fuhong; Hayashi, Yoshihiro; Dong, Yunzhu; Rao, Yalan; Li, Bo; Conway, Rajeana M; Maiques-Diaz, Alba; Elf, Shannon E; Huang, Nuomin; Zuber, Johannes; Xiao, Zhijian; Tse, William; Tenen, Daniel G; Wang, Qianfei; Chen, Wei; Mulloy, James C; Nimer, Stephen D; Huang, Gang (2014. ) Downregulation of RUNX1/CBFbeta by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Blood, , 123 (11 ) ,1729-38 More Information

Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton (2014. ) Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.The Journal of clinical investigation, , 124 (1 ) ,222-36 More Information

Mulloy, James C (2013. ) A new inducible model for t(8;21) AML.EMBO molecular medicine, , 5 (12 ) ,1795-7 More Information

Goyama, Susumu; Mulloy, James C (2013. ) NF-kappaB: a coordinator for epigenetic regulation by MLL.Cancer cell, , 24 (4 ) ,401-2 More Information

Neviani, Paolo; Harb, Jason G; Oaks, Joshua J; Santhanam, Ramasamy; Walker, Christopher J; Ellis, Justin J; Ferenchak, Gregory; Dorrance, Adrienne M; Paisie, Carolyn A; Eiring, Anna M; Ma, Yihui; Mao, Hsiaoyin C; Zhang, Bin; Wunderlich, Mark; May, Philippa C; Sun, Chaode; Saddoughi, Sahar A; Bielawski, Jacek; Blum, William; Klisovic, Rebecca B; Solt, Janelle A; Byrd, John C; Volinia, Stefano; Cortes, Jorge; Huettner, Claudia S; Koschmieder, Steffen; Holyoake, Tessa L; Devine, Steven; Caligiuri, Michael A; Croce, Carlo M; Garzon, Ramiro; Ogretmen, Besim; Arlinghaus, Ralph B; Chen, Ching-Shih; Bittman, Robert; Hokland, Peter; Roy, Denis-Claude; Milojkovic, Dragana; Apperley, Jane; Goldman, John M; Reid, Alistair; Mulloy, James C; Bhatia, Ravi; Marcucci, Guido; Perrotti, Danilo (2013. ) PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.The Journal of clinical investigation, , 123 (10 ) ,4144-57 More Information

Goyama, Susumu; Schibler, Janet; Cunningham, Lea; Zhang, Yue; Rao, Yalan; Nishimoto, Nahoko; Nakagawa, Masahiro; Olsson, Andre; Wunderlich, Mark; Link, Kevin A; Mizukawa, Benjamin; Grimes, H Leighton; Kurokawa, Mineo; Liu, P Paul; Huang, Gang; Mulloy, James C (2013. ) Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.The Journal of clinical investigation, , 123 (9 ) ,3876-88 More Information

Araten, David J; Krejci, Ondrej; Ditata, Kimberly; Wunderlich, Mark; Sanders, Katie J; Zamechek, Leah; Mulloy, James C (2013. ) The rate of spontaneous mutations in human myeloid cells.Mutation research, , 749 (1-2 ) ,49-57 More Information

Huang, Hao; Jiang, Xi; Li, Zejuan; Li, Yuanyuan; Song, Chun-Xiao; He, Chunjiang; Sun, Miao; Chen, Ping; Gurbuxani, Sandeep; Wang, Jiapeng; Hong, Gia-Ming; Elkahloun, Abdel G; Arnovitz, Stephen; Wang, Jinhua; Szulwach, Keith; Lin, Li; Street, Craig; Wunderlich, Mark; Dawlaty, Meelad; Neilly, Mary Beth; Jaenisch, Rudolf; Yang, Feng-Chun; Mulloy, James C; Jin, Peng; Liu, Paul P; Rowley, Janet D; Xu, Mingjiang; He, Chuan; Chen, Jianjun (2013. ) TET1 plays an essential oncogenic role in MLL-rearranged leukemia.Proceedings of the National Academy of Sciences of the United States of America, , 110 (29 ) ,11994-9 More Information

Chen, Ping; Price, Colles; Li, Zejuan; Li, Yuanyuan; Cao, Donglin; Wiley, Anissa; He, Chunjiang; Gurbuxani, Sandeep; Kunjamma, Rejani B; Huang, Hao; Jiang, Xi; Arnovitz, Stephen; Xu, Mengyi; Hong, Gia-Ming; Elkahloun, Abdel G; Neilly, Mary Beth; Wunderlich, Mark; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun (2013. ) miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.Proceedings of the National Academy of Sciences of the United States of America, , 110 (28 ) ,11511-6 More Information

Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T (2013. ) Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.Cancer cell, , 24 (1 ) ,90-104 More Information

Bell-Horwath, Tiffany R; Vadukoot, Anish K; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C; Merino, Edward J (2013. ) Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia.Bioorganic & medicinal chemistry letters, , 23 (10 ) ,2951-4 More Information

Wunderlich, Mark; Mizukawa, Benjamin; Chou, Fu-Sheng; Sexton, Christina; Shrestha, Mahesh; Saunthararajah, Yogen; Mulloy, James C (2013. ) AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.Blood, , 121 (12 ) ,e90-7 More Information

Goyama, Susumu; Mulloy, James C (2013. ) Making healthy stem cells: the new role of TPO.Cell stem cell, , 12 (1 ) ,8-9 More Information

Jiang, Xi; Huang, Hao; Li, Zejuan; He, Chunjiang; Li, Yuanyuan; Chen, Ping; Gurbuxani, Sandeep; Arnovitz, Stephen; Hong, Gia-Ming; Price, Colles; Ren, Haomin; Kunjamma, Rejani B; Neilly, Mary Beth; Salat, Justin; Wunderlich, Mark; Slany, Robert K; Zhang, Yanming; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Rowley, Janet D; Chen, Jianjun (2012. ) MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.Proceedings of the National Academy of Sciences of the United States of America, , 109 (47 ) ,19397-402 More Information

Zhang, Yue; Yan, Xiaomei; Sashida, Goro; Zhao, Xinghui; Rao, Yalan; Goyama, Susumu; Whitman, Susan P; Zorko, Nicholas; Bernot, Kelsie; Conway, Rajeana M; Witte, David; Wang, Qian-Fei; Tenen, Daniel G; Xiao, Zhijian; Marcucci, Guido; Mulloy, James C; Grimes, H Leighton; Caligiuri, Michael A; Huang, Gang (2012. ) Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.Blood, , 120 (5 ) ,1118-29 More Information

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T (2012. ) Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.Blood, , 120 (4 ) ,858-67 More Information

Chou, Fu-Sheng; Griesinger, Andrea; Wunderlich, Mark; Lin, Shan; Link, Kevin A; Shrestha, Mahesh; Goyama, Susumu; Mizukawa, Benjamin; Shen, Shuhong; Marcucci, Guido; Mulloy, James C (2012. ) The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.Blood, , 120 (4 ) ,709-19 More Information

Yoshimi, Mayumi; Goyama, Susumu; Kawazu, Masahito; Nakagawa, Masahiro; Ichikawa, Motoshi; Imai, Yoichi; Kumano, Keiki; Asai, Takashi; Mulloy, James C; Kraft, Andrew S; Takahashi, Tsuyoshi; Shirafuji, Naoki; Kurokawa, Mineo (2012. ) Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.European journal of immunology, , 42 (4 ) ,1044-50 More Information

Li, Zejuan; Huang, Hao; Chen, Ping; He, Miao; Li, Yuanyuan; Arnovitz, Stephen; Jiang, Xi; He, Chunjiang; Hyjek, Elizabeth; Zhang, Jun; Zhang, Zhiyu; Elkahloun, Abdel; Cao, Donglin; Shen, Chen; Wunderlich, Mark; Wang, Yungui; Neilly, Mary Beth; Jin, Jie; Wei, Minjie; Lu, Jun; Valk, Peter J M; Delwel, Ruud; Lowenberg, Bob; Le Beau, Michelle M; Vardiman, James; Mulloy, James C; Zeleznik-Le, Nancy J; Liu, Paul P; Zhang, Jiwang; Chen, Jianjun (2012. ) miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.Nature communications, , 3 ,688 More Information

Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C (2011. ) Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Blood, , 118 (19 ) ,5235-45 More Information

Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi (2011. ) Cdc42 regulates extracellular matrix remodeling in three dimensions.The Journal of biological chemistry, , 286 (42 ) ,36469-77 More Information

Zuber, Johannes; Shi, Junwei; Wang, Eric; Rappaport, Amy R; Herrmann, Harald; Sison, Edward A; Magoon, Daniel; Qi, Jun; Blatt, Katharina; Wunderlich, Mark; Taylor, Meredith J; Johns, Christopher; Chicas, Agustin; Mulloy, James C; Kogan, Scott C; Brown, Patrick; Valent, Peter; Bradner, James E; Lowe, Scott W; Vakoc, Christopher R (2011. ) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.Nature, , 478 (7370 ) ,524-8 More Information

Goyama, Susumu; Mulloy, James C (2011. ) Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects.International journal of hematology, , 94 (2 ) ,126-33 More Information

Chou, Fu-Sheng; Mulloy, James C (2011. ) The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis.Journal of cellular biochemistry, , 112 (6 ) ,1491-8 More Information

Chou, Fu-Sheng; Wunderlich, Mark; Griesinger, Andrea; Mulloy, James C (2011. ) N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene.Blood, , 117 (7 ) ,2237-40 More Information

Alvarez, Sara; Suela, Javier; Valencia, Ana; Fernández, Agustín; Wunderlich, Mark; Agirre, Xabier; Prósper, Felipe; Martín-Subero, José Ignacio; Maiques, Alba; Acquadro, Francesco; Rodriguez Perales, Sandra; Calasanz, María José; Roman-Gómez, Jose; Siebert, Reiner; Mulloy, James C; Cervera, José; Sanz, Miguel Angel; Esteller, Manel; Cigudosa, Juan C (2010. ) DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.PloS one, , 5 (8 ) ,e12197 More Information

Kamikubo, Yasuhiko; Zhao, Ling; Wunderlich, Mark; Corpora, Takeshi; Hyde, R Katherine; Paul, Thomas A; Kundu, Mondira; Garrett, Lisa; Compton, Sheila; Huang, Gang; Wolff, Linda; Ito, Yoshiaki; Bushweller, John; Mulloy, James C; Liu, P Paul (2010. ) Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1.Cancer cell, , 17 (5 ) ,455-68 More Information

Mulloy, James C (2010. ) Peripheral T cell lymphoma: new model + new insight.The Journal of experimental medicine, , 207 (5 ) ,911-3 More Information

Mi, Shuangli; Li, Zejuan; Chen, Ping; He, Chunjiang; Cao, Donglin; Elkahloun, Abdel; Lu, Jun; Pelloso, Luis A; Wunderlich, Mark; Huang, Hao; Luo, Roger T; Sun, Miao; He, Miao; Neilly, Mary Beth; Zeleznik-Le, Nancy J; Thirman, Michael J; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun (2010. ) Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia.Proceedings of the National Academy of Sciences of the United States of America, , 107 (8 ) ,3710-5 More Information

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47 More Information

Link, Kevin A; Chou, Fu-Sheng; Mulloy, James C (2010. ) Core binding factor at the crossroads: determining the fate of the HSC.Journal of cellular physiology, , 222 (1 ) ,50-6 More Information

Wunderlich, Mark; Mulloy, James C (2009. ) Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.Methods in molecular biology (Clifton, N.J.), , 538 ,263-85 More Information

Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping (2008. ) Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), , 7 (21 ) ,3314-9

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C (2008. ) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Cancer cell, , 13 (6 ) ,483-95 More Information

Krejci, Ondrej; Wunderlich, Mark; Geiger, Hartmut; Chou, Fu-Sheng; Schleimer, David; Jansen, Michael; Andreassen, Paul R; Mulloy, James C (2008. ) p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death.Blood, , 111 (4 ) ,2190-9 More Information

Wunderlich, Mark; Krejci, Ondrej; Wei, Junping; Mulloy, James C (2006. ) Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.Blood, , 108 (5 ) ,1690-7 More Information

Mulloy, James C; Jankovic, Vladimir; Wunderlich, Mark; Delwel, Ruud; Cammenga, Jorg; Krejci, Ondrej; Zhao, Hui; Valk, Peter J M; Lowenberg, Bob; Nimer, Stephen D (2005. ) AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.Proceedings of the National Academy of Sciences of the United States of America, , 102 (11 ) ,4016-21 More Information

Mulloy, James C; Cammenga, Jorg; Berguido, Francisco J; Wu, Kaida; Zhou, Ping; Comenzo, Raymond L; Jhanwar, Suresh; Moore, Malcolm A S; Nimer, Stephen D (2003. ) Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.Blood, , 102 (13 ) ,4369-76 More Information

Cammenga, Jörg; Mulloy, James C; Berguido, Francisco J; MacGrogan, Donal; Viale, Agnes; Nimer, Stephen D (2003. ) Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.Blood, , 101 (6 ) ,2206-14 More Information

Mulloy, James C; Cammenga, Jörg; MacKenzie, Karen L; Berguido, Francisco J; Moore, Malcolm A S; Nimer, Stephen D (2002. ) The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood, , 99 (1 ) ,15-23

Benito, Juliana M; Godfrey, Laura; Kojima, Kensuke; Hogdal, Leah; Wunderlich, Mark; Geng, Huimin; Marzo, Isabel; Harutyunyan, Karine G; Golfman, Leonard; North, Phillip; Kerry, Jon; Ballabio, Erica; Chonghaile, Triona Ní; Gonzalo, Oscar; Qiu, Yihua; Jeremias, Irmela; Debose, LaKiesha; O'Brien, Eric; Ma, Helen; Zhou, Ping; Jacamo, Rodrigo; Park, Eugene; Coombes, Kevin R; Zhang, Nianxiang; Thomas, Deborah A; O'Brien, Susan; Kantarjian, Hagop M; Leverson, Joel D; Kornblau, Steven M; Andreeff, Michael; Müschen, Markus; Zweidler-McKay, Patrick A; Mulloy, James C; Letai, Anthony; Milne, Thomas A; Konopleva, Marina (2015. ) MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.Cell reports, , 13 (12 ) ,2715-27 More Information

Glait-Santar, Chen; Desmond, Ronan; Feng, Xingmin; Bat, Taha; Chen, Jichun; Heuston, Elisabeth; Mizukawa, Benjamin; Mulloy, James C; Bodine, David M; Larochelle, Andre; Dunbar, Cynthia E (2015. ) Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells.Stem cells (Dayton, Ohio), , 33 (12 ) ,3635-42 More Information

Ågerstam, Helena; Karlsson, Christine; Hansen, Nils; Sandén, Carl; Askmyr, Maria; von Palffy, Sofia; Högberg, Carl; Rissler, Marianne; Wunderlich, Mark; Juliusson, Gunnar; Richter, Johan; Sjöström, Kjell; Bhatia, Ravi; Mulloy, James C; Järås, Marcus; Fioretos, Thoas (2015. ) Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America, , 112 (34 ) ,10786-91 More Information

Maiques-Diaz, Alba; Hernando, Miriam; Sánchez-López, Amanda; Rio-Machin, Ana; Shrestha, Mahesh; Mulloy, James C; Cigudosa, Juan C; Alvarez, Sara (2015. ) MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia.British journal of haematology, , 172 (5 ) ,807-10 More Information

Goyama, Susumu; Wunderlich, Mark; Mulloy, James C (2015. ) Xenograft models for normal and malignant stem cells.Blood, , 125 (17 ) ,2630-40 More Information

Roychoudhury, Jayeeta; Clark, Jason P; Gracia-Maldonado, Gabriel; Unnisa, Zeenath; Wunderlich, Mark; Link, Kevin A; Dasgupta, Nupur; Aronow, Bruce; Huang, Gang; Mulloy, James C; Kumar, Ashish R (2015. ) MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.Blood, , 125 (16 ) ,2544-52 More Information

Vadukoot, Anish K; AbdulSalam, Safnas F; Wunderlich, Mark; Pullen, Eboni D; Landero-Figueroa, Julio; Mulloy, James C; Merino, Eddie J (2014. ) Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells.Bioorganic & medicinal chemistry, , 22 (24 ) ,6885-92 More Information

james.mulloy@cchmc.org