Publications
Peer Reviewed Publications
Wunderlich, Mark; Brooks, Ryan A; Panchal, Rushi; Rhyasen, Garrett W; Danet-Desnoyers, Gwenn; Mulloy, James C (2014). OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood, 123 (24) , e134-44More Information
Kong, Guangyao; Wunderlich, Mark; Yang, David; Ranheim, Erik A; Young, Ken H; Wang, Jinyong; Chang, Yuan-I; Du, Juan; Liu, Yangang; Tey, Sin Ruow; Zhang, Xinmin; Juckett, Mark; Mattison, Ryan; Damnernsawad, Alisa; Zhang, Jingfang; Mulloy, James C; Zhang, Jing (2014). Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of clinical investigation, 124 (6) , 2762-73More Information
Zhao, Xinghui; Chen, Aili; Yan, Xiaomei; Zhang, Yue; He, Fuhong; Hayashi, Yoshihiro; Dong, Yunzhu; Rao, Yalan; Li, Bo; Conway, Rajeana M; Maiques-Diaz, Alba; Elf, Shannon E; Huang, Nuomin; Zuber, Johannes; Xiao, Zhijian; Tse, William; Tenen, Daniel G; Wang, Qianfei; Chen, Wei; Mulloy, James C; Nimer, Stephen D; Huang, Gang (2014). Downregulation of RUNX1/CBFbeta by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood, 123 (11) , 1729-38More Information
Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton (2014). Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. The Journal of clinical investigation, 124 (1) , 222-36More Information
Mulloy, James C (2013). A new inducible model for t(8;21) AML. EMBO molecular medicine, 5 (12) , 1795-7More Information
Goyama, Susumu; Mulloy, James C (2013). NF-kappaB: a coordinator for epigenetic regulation by MLL. Cancer cell, 24 (4) , 401-2More Information
Neviani, Paolo; Harb, Jason G; Oaks, Joshua J; Santhanam, Ramasamy; Walker, Christopher J; Ellis, Justin J; Ferenchak, Gregory; Dorrance, Adrienne M; Paisie, Carolyn A; Eiring, Anna M; Ma, Yihui; Mao, Hsiaoyin C; Zhang, Bin; Wunderlich, Mark; May, Philippa C; Sun, Chaode; Saddoughi, Sahar A; Bielawski, Jacek; Blum, William; Klisovic, Rebecca B; Solt, Janelle A; Byrd, John C; Volinia, Stefano; Cortes, Jorge; Huettner, Claudia S; Koschmieder, Steffen; Holyoake, Tessa L; Devine, Steven; Caligiuri, Michael A; Croce, Carlo M; Garzon, Ramiro; Ogretmen, Besim; Arlinghaus, Ralph B; Chen, Ching-Shih; Bittman, Robert; Hokland, Peter; Roy, Denis-Claude; Milojkovic, Dragana; Apperley, Jane; Goldman, John M; Reid, Alistair; Mulloy, James C; Bhatia, Ravi; Marcucci, Guido; Perrotti, Danilo (2013). PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of clinical investigation, 123 (10) , 4144-57More Information
Goyama, Susumu; Schibler, Janet; Cunningham, Lea; Zhang, Yue; Rao, Yalan; Nishimoto, Nahoko; Nakagawa, Masahiro; Olsson, Andre; Wunderlich, Mark; Link, Kevin A; Mizukawa, Benjamin; Grimes, H Leighton; Kurokawa, Mineo; Liu, P Paul; Huang, Gang; Mulloy, James C (2013). Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. The Journal of clinical investigation, 123 (9) , 3876-88More Information
Araten, David J; Krejci, Ondrej; Ditata, Kimberly; Wunderlich, Mark; Sanders, Katie J; Zamechek, Leah; Mulloy, James C (2013). The rate of spontaneous mutations in human myeloid cells. Mutation research, 749 (1-2) , 49-57More Information
Huang, Hao; Jiang, Xi; Li, Zejuan; Li, Yuanyuan; Song, Chun-Xiao; He, Chunjiang; Sun, Miao; Chen, Ping; Gurbuxani, Sandeep; Wang, Jiapeng; Hong, Gia-Ming; Elkahloun, Abdel G; Arnovitz, Stephen; Wang, Jinhua; Szulwach, Keith; Lin, Li; Street, Craig; Wunderlich, Mark; Dawlaty, Meelad; Neilly, Mary Beth; Jaenisch, Rudolf; Yang, Feng-Chun; Mulloy, James C; Jin, Peng; Liu, Paul P; Rowley, Janet D; Xu, Mingjiang; He, Chuan; Chen, Jianjun (2013). TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110 (29) , 11994-9More Information
Chen, Ping; Price, Colles; Li, Zejuan; Li, Yuanyuan; Cao, Donglin; Wiley, Anissa; He, Chunjiang; Gurbuxani, Sandeep; Kunjamma, Rejani B; Huang, Hao; Jiang, Xi; Arnovitz, Stephen; Xu, Mengyi; Hong, Gia-Ming; Elkahloun, Abdel G; Neilly, Mary Beth; Wunderlich, Mark; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun (2013). miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110 (28) , 11511-6More Information
Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T (2013). Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 (1) , 90-104More Information
Bell-Horwath, Tiffany R; Vadukoot, Anish K; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C; Merino, Edward J (2013). Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia. Bioorganic & medicinal chemistry letters, 23 (10) , 2951-4More Information
Wunderlich, Mark; Mizukawa, Benjamin; Chou, Fu-Sheng; Sexton, Christina; Shrestha, Mahesh; Saunthararajah, Yogen; Mulloy, James C (2013). AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model. Blood, 121 (12) , e90-7More Information
Goyama, Susumu; Mulloy, James C (2013). Making healthy stem cells: the new role of TPO. Cell stem cell, 12 (1) , 8-9More Information
Jiang, Xi; Huang, Hao; Li, Zejuan; He, Chunjiang; Li, Yuanyuan; Chen, Ping; Gurbuxani, Sandeep; Arnovitz, Stephen; Hong, Gia-Ming; Price, Colles; Ren, Haomin; Kunjamma, Rejani B; Neilly, Mary Beth; Salat, Justin; Wunderlich, Mark; Slany, Robert K; Zhang, Yanming; Larson, Richard A; Le Beau, Michelle M; Mulloy, James C; Rowley, Janet D; Chen, Jianjun (2012). MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 109 (47) , 19397-402More Information
Zhang, Yue; Yan, Xiaomei; Sashida, Goro; Zhao, Xinghui; Rao, Yalan; Goyama, Susumu; Whitman, Susan P; Zorko, Nicholas; Bernot, Kelsie; Conway, Rajeana M; Witte, David; Wang, Qian-Fei; Tenen, Daniel G; Xiao, Zhijian; Marcucci, Guido; Mulloy, James C; Grimes, H Leighton; Caligiuri, Michael A; Huang, Gang (2012). Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood, 120 (5) , 1118-29More Information
Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T (2012). Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 (4) , 858-67More Information
Chou, Fu-Sheng; Griesinger, Andrea; Wunderlich, Mark; Lin, Shan; Link, Kevin A; Shrestha, Mahesh; Goyama, Susumu; Mizukawa, Benjamin; Shen, Shuhong; Marcucci, Guido; Mulloy, James C (2012). The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO. Blood, 120 (4) , 709-19More Information
Yoshimi, Mayumi; Goyama, Susumu; Kawazu, Masahito; Nakagawa, Masahiro; Ichikawa, Motoshi; Imai, Yoichi; Kumano, Keiki; Asai, Takashi; Mulloy, James C; Kraft, Andrew S; Takahashi, Tsuyoshi; Shirafuji, Naoki; Kurokawa, Mineo (2012). Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. European journal of immunology, 42 (4) , 1044-50More Information
Li, Zejuan; Huang, Hao; Chen, Ping; He, Miao; Li, Yuanyuan; Arnovitz, Stephen; Jiang, Xi; He, Chunjiang; Hyjek, Elizabeth; Zhang, Jun; Zhang, Zhiyu; Elkahloun, Abdel; Cao, Donglin; Shen, Chen; Wunderlich, Mark; Wang, Yungui; Neilly, Mary Beth; Jin, Jie; Wei, Minjie; Lu, Jun; Valk, Peter J M; Delwel, Ruud; Lowenberg, Bob; Le Beau, Michelle M; Vardiman, James; Mulloy, James C; Zeleznik-Le, Nancy J; Liu, Paul P; Zhang, Jiwang; Chen, Jianjun (2012). miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nature communications, 3, 688More Information
Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C (2011). Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 (19) , 5235-45More Information
Sipes, Nisha S; Feng, Yuxin; Guo, Fukun; Lee, Hyung-Ok; Chou, Fu-Sheng; Cheng, Jonathan; Mulloy, James; Zheng, Yi (2011). Cdc42 regulates extracellular matrix remodeling in three dimensions. The Journal of biological chemistry, 286 (42) , 36469-77More Information
Zuber, Johannes; Shi, Junwei; Wang, Eric; Rappaport, Amy R; Herrmann, Harald; Sison, Edward A; Magoon, Daniel; Qi, Jun; Blatt, Katharina; Wunderlich, Mark; Taylor, Meredith J; Johns, Christopher; Chicas, Agustin; Mulloy, James C; Kogan, Scott C; Brown, Patrick; Valent, Peter; Bradner, James E; Lowe, Scott W; Vakoc, Christopher R (2011). RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478 (7370) , 524-8More Information
Goyama, Susumu; Mulloy, James C (2011). Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. International journal of hematology, 94 (2) , 126-33More Information
Chou, Fu-Sheng; Mulloy, James C (2011). The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. Journal of cellular biochemistry, 112 (6) , 1491-8More Information
Chou, Fu-Sheng; Wunderlich, Mark; Griesinger, Andrea; Mulloy, James C (2011). N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood, 117 (7) , 2237-40More Information
Alvarez, Sara; Suela, Javier; Valencia, Ana; Fernández, Agustín; Wunderlich, Mark; Agirre, Xabier; Prósper, Felipe; Martín-Subero, José Ignacio; Maiques, Alba; Acquadro, Francesco; Rodriguez Perales, Sandra; Calasanz, María José; Roman-Gómez, Jose; Siebert, Reiner; Mulloy, James C; Cervera, José; Sanz, Miguel Angel; Esteller, Manel; Cigudosa, Juan C (2010). DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PloS one, 5 (8) , e12197More Information
Kamikubo, Yasuhiko; Zhao, Ling; Wunderlich, Mark; Corpora, Takeshi; Hyde, R Katherine; Paul, Thomas A; Kundu, Mondira; Garrett, Lisa; Compton, Sheila; Huang, Gang; Wolff, Linda; Ito, Yoshiaki; Bushweller, John; Mulloy, James C; Liu, P Paul (2010). Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1. Cancer cell, 17 (5) , 455-68More Information
Mulloy, James C (2010). Peripheral T cell lymphoma: new model + new insight. The Journal of experimental medicine, 207 (5) , 911-3More Information
Mi, Shuangli; Li, Zejuan; Chen, Ping; He, Chunjiang; Cao, Donglin; Elkahloun, Abdel; Lu, Jun; Pelloso, Luis A; Wunderlich, Mark; Huang, Hao; Luo, Roger T; Sun, Miao; He, Miao; Neilly, Mary Beth; Zeleznik-Le, Nancy J; Thirman, Michael J; Mulloy, James C; Liu, Paul P; Rowley, Janet D; Chen, Jianjun (2010). Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proceedings of the National Academy of Sciences of the United States of America, 107 (8) , 3710-5More Information
Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010). Rho GTPases in hematopoiesis and hemopathies. Blood, 115 (5) , 936-47More Information
Link, Kevin A; Chou, Fu-Sheng; Mulloy, James C (2010). Core binding factor at the crossroads: determining the fate of the HSC. Journal of cellular physiology, 222 (1) , 50-6More Information
Wunderlich, Mark; Mulloy, James C (2009). Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction. Methods in molecular biology (Clifton, N.J.), 538, 263-85More Information
Mulloy, James C; Wunderlich, Mark; Zheng, Yi; Wei, Junping (2008). Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling. Cell cycle (Georgetown, Tex.), 7 (21) , 3314-9
Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C (2008). Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer cell, 13 (6) , 483-95More Information
Krejci, Ondrej; Wunderlich, Mark; Geiger, Hartmut; Chou, Fu-Sheng; Schleimer, David; Jansen, Michael; Andreassen, Paul R; Mulloy, James C (2008). p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Blood, 111 (4) , 2190-9More Information
Wunderlich, Mark; Krejci, Ondrej; Wei, Junping; Mulloy, James C (2006). Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood, 108 (5) , 1690-7More Information
Mulloy, James C; Jankovic, Vladimir; Wunderlich, Mark; Delwel, Ruud; Cammenga, Jorg; Krejci, Ondrej; Zhao, Hui; Valk, Peter J M; Lowenberg, Bob; Nimer, Stephen D (2005). AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion. Proceedings of the National Academy of Sciences of the United States of America, 102 (11) , 4016-21More Information
Mulloy, James C; Cammenga, Jorg; Berguido, Francisco J; Wu, Kaida; Zhou, Ping; Comenzo, Raymond L; Jhanwar, Suresh; Moore, Malcolm A S; Nimer, Stephen D (2003). Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood, 102 (13) , 4369-76More Information
Cammenga, Jörg; Mulloy, James C; Berguido, Francisco J; MacGrogan, Donal; Viale, Agnes; Nimer, Stephen D (2003). Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood, 101 (6) , 2206-14More Information
Mulloy, James C; Cammenga, Jörg; MacKenzie, Karen L; Berguido, Francisco J; Moore, Malcolm A S; Nimer, Stephen D (2002). The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood, 99 (1) , 15-23
Benito, Juliana M; Godfrey, Laura; Kojima, Kensuke; Hogdal, Leah; Wunderlich, Mark; Geng, Huimin; Marzo, Isabel; Harutyunyan, Karine G; Golfman, Leonard; North, Phillip; Kerry, Jon; Ballabio, Erica; Chonghaile, Triona Ní; Gonzalo, Oscar; Qiu, Yihua; Jeremias, Irmela; Debose, LaKiesha; O'Brien, Eric; Ma, Helen; Zhou, Ping; Jacamo, Rodrigo; Park, Eugene; Coombes, Kevin R; Zhang, Nianxiang; Thomas, Deborah A; O'Brien, Susan; Kantarjian, Hagop M; Leverson, Joel D; Kornblau, Steven M; Andreeff, Michael; Müschen, Markus; Zweidler-McKay, Patrick A; Mulloy, James C; Letai, Anthony; Milne, Thomas A; Konopleva, Marina (2015). MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell reports, 13 (12) , 2715-27More Information
Glait-Santar, Chen; Desmond, Ronan; Feng, Xingmin; Bat, Taha; Chen, Jichun; Heuston, Elisabeth; Mizukawa, Benjamin; Mulloy, James C; Bodine, David M; Larochelle, Andre; Dunbar, Cynthia E (2015). Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells. Stem cells (Dayton, Ohio), 33 (12) , 3635-42More Information
Ågerstam, Helena; Karlsson, Christine; Hansen, Nils; Sandén, Carl; Askmyr, Maria; von Palffy, Sofia; Högberg, Carl; Rissler, Marianne; Wunderlich, Mark; Juliusson, Gunnar; Richter, Johan; Sjöström, Kjell; Bhatia, Ravi; Mulloy, James C; Järås, Marcus; Fioretos, Thoas (2015). Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 112 (34) , 10786-91More Information
Maiques-Diaz, Alba; Hernando, Miriam; Sánchez-López, Amanda; Rio-Machin, Ana; Shrestha, Mahesh; Mulloy, James C; Cigudosa, Juan C; Alvarez, Sara (2015). MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia. British journal of haematology, 172 (5) , 807-10More Information
Goyama, Susumu; Wunderlich, Mark; Mulloy, James C (2015). Xenograft models for normal and malignant stem cells. Blood, 125 (17) , 2630-40More Information
Roychoudhury, Jayeeta; Clark, Jason P; Gracia-Maldonado, Gabriel; Unnisa, Zeenath; Wunderlich, Mark; Link, Kevin A; Dasgupta, Nupur; Aronow, Bruce; Huang, Gang; Mulloy, James C; Kumar, Ashish R (2015). MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood, 125 (16) , 2544-52More Information
Vadukoot, Anish K; AbdulSalam, Safnas F; Wunderlich, Mark; Pullen, Eboni D; Landero-Figueroa, Julio; Mulloy, James C; Merino, Eddie J (2014). Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells. Bioorganic & medicinal chemistry, 22 (24) , 6885-92More Information
Contact Information
james.mulloy@cchmc.org