Michael K. Murawsky

Sr Research Assistant

Senior Research Associate

Medical Sciences Building

2102

Pharmacy Li Lab - 0004

Education

M.S.: COM, University of Cincinnati Cincinnati, OH, 1990 (Physiology / Biophysics)

B.S.: Bowling Green State University Bowling Green, OH, 1980 (Microbiology / Chemistry)

Positions and Work Experience

1980 -1983 Research Assistant Dept of Biochemistry, COM, University of Virginia, Charlottesville, VA

1983 -1988 Research Assistant Physiology & Biophysics, COM, University of Cincinnati, Cincinnati, OH

1988 -1996 Research Neurophysiologist, Cerebrovascular Diseases, Marion Merrell Dow Pharmaceuticals, Cincinnati, OH

1996 -2005 Associate Research Scientist, Cardiac Research, Procter and Gamble Pharmaceuticals, Cincinnati, OH

2005 - Sr. Research Assistant, COP, University of Cincinnati, Cincinnati, OH

Publications

Peer Reviewed Publications

Zhang, Qian; Murawsky, Michael; LaCount, Terri D; Hao, Jinsong; Ghosh, Priyanka; Raney, Sam G; Kasting, Gerald B; Li, S Kevin (2020. ) Evaluation of Heat Effects on Fentanyl Transdermal Delivery Systems Using In Vitro Permeation and In Vitro Release Methods.Journal of pharmaceutical sciences, , 109 (10 ) ,3095-3104 More Information

La Count, Terri D; Zhang, Qian; Murawsky, Michael; Hao, Jinsong; Ghosh, Priyanka; Dave, Kaushalkumar; Raney, Sam G; Talattof, Arjang; Kasting, Gerald B; Li, S Kevin (2020. ) Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport Model Analysis.The AAPS journal, , 22 (4 ) ,82 More Information

Ren, Wei; Murawsky, Michael; La Count, Terri; Wanasathop, Apipa; Hao, Xin; Kelm, Gary R; Kozak, Darby; Qin, Bin; Li, S Kevin (2019. ) Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket.The AAPS journal, , 21 (3 ) ,51 More Information

Murawsky, Michael; Kelm, Gary R; Kozak, Darby; Qin, Bin; Zou, Yuan; Li, S Kevin (2019. ) Influencing factors on gelatin matrix for chlorhexidine delivery.Drug development and industrial pharmacy, , 45 (2 ) ,314-322 More Information

Zhang, Qian; Murawsky, Michael; LaCount, Terri; Kasting, Gerald B; Li, S Kevin (2018. ) Transepidermal water loss and skin conductance as barrier integrity tests.Toxicology in vitro : an international journal published in association with BIBRA, , 51 ,129-135 More Information

Zhang, Qian; Murawsky, Michael; LaCount, Terri; Hao, Jinsong; Kasting, Gerald B; Newman, Bryan; Ghosh, Priyanka; Raney, Sam G; Li, S Kevin (2017. ) Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro.Pharmaceutical research, , 34 (7 ) ,1491-1504 More Information

Christensen, Heather R; Murawsky, Michael K; Horseman, Nelson D; Willson, Tara A; Gregerson, Karen A (2013. ) Completely humanizing prolactin rescues infertility in prolactin knockout mice and leads to human prolactin expression in extrapituitary mouse tissues.Endocrinology, , 154 (12 ) ,4777-89 More Information

Christensen, Heather R; Zeng, Qinghua; Murawsky, Michael K; Gregerson, Karen A (2011. ) Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.American journal of physiology. Regulatory, integrative and comparative physiology, , 301 (3 ) ,R746-56 More Information

Jackson, Chris M; Blass, Benjamin; Coburn, Keith; Djandjighian, Laurent; Fadayel, Gina; Fluxe, Andrew J; Hodson, Steven J; Janusz, John M; Murawsky, Michael; Ridgeway, James M; White, Ronald E; Wu, Shengde (2007. ) Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.Bioorganic & medicinal chemistry letters, , 17 (1 ) ,282-4 More Information

Wu, Shengde; Fluxe, Andrew; Sheffer, Jim; Janusz, John M; Blass, Benjamin E; White, Ron; Jackson, Chris; Hedges, Richard; Murawsky, Michael; Fang, Bin; Fadayel, Gina M; Hare, Michelle; Djandjighian, Laurent (2006. ) Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers.Bioorganic & medicinal chemistry letters, , 16 (24 ) ,6213-8 More Information

Fluxe, Andrew; Wu, Shengde; Sheffer, James B; Janusz, John M; Murawsky, Michael; Fadayel, Gina M; Fang, Bin; Hare, Michelle; Djandjighian, Laurent (2006. ) Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers.Bioorganic & medicinal chemistry letters, , 16 (22 ) ,5855-8 More Information

Wu, Shengde; Fluxe, Andrew; Janusz, John M; Sheffer, James B; Browning, Greg; Blass, Benjamin; Cobum, Keith; Hedges, Richard; Murawsky, Michael; Fang, Bin; Fadayel, Gina M; Hare, Michelle; Djandjighian, Laurent (2006. ) Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers.Bioorganic & medicinal chemistry letters, , 16 (22 ) ,5859-63 More Information

Blass, Benjamin E; Coburn, Keith; Lee, Wenlin; Fairweather, Neil; Fluxe, Andrew; Wu, Shengde; Janusz, John M; Murawsky, Michael; Fadayel, Gina M; Fang, Bin; Hare, Michelle; Ridgeway, Jim; White, Ron; Jackson, Chris; Djandjighian, Laurent; Hedges, Richard; Wireko, Fred C; Ritter, Amanda L (2006. ) Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.Bioorganic & medicinal chemistry letters, , 16 (17 ) ,4629-32 More Information

Matsuno, Nobunaka; Murawsky, Michael; Ridgeway, James; Cuppoletti, John (2004. ) Solid support membranes for ion channel arrays and sensors: application to rapid screening of pharmacological compounds.Biochimica et biophysica acta, , 1665 (1-2 ) ,184-90 More Information

Rampe, D; Murawsky, M K; Grau, J; Lewis, E W (1998. ) The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG. The Journal of pharmacology and experimental therapeutics, , 286 (2 ) ,788-93

Wible, B; Murawsky, M K; Crumb, W J; Rampe, D (1997. ) Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents.Brain research, , 761 (1 ) ,42-50 More Information

Rampe, D; Murawsky, M K (1997. ) Blockade of the human cardiac K+ channel Kv1.5 by the antibiotic erythromycin.Naunyn-Schmiedeberg's archives of pharmacology, , 355 (6 ) ,743-50 More Information

Baron, B M; Harrison, B L; Kehne, J H; Schmidt, C J; van Giersbergen, P L; White, H S; Siegel, B W; Senyah, Y; McCloskey, T C; Fadayel, G M; Taylor, V L; Murawsky, M K; Nyce, P; Salituro, F G (1997. ) Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.European journal of pharmacology, , 323 (2-3 ) ,181-92 More Information

Cheek, T R; Murawsky, M M; Stauderman, K A (1994. ) Histamine-induced Ca2+ entry precedes Ca2+ mobilization in bovine adrenal chromaffin cells.The Biochemical journal, , 304 ( Pt 2) ,469-76 More Information

Cheek, T R; Berridge, M J; Moreton, R B; Stauderman, K A; Murawsky, M M; Bootman, M D (1994. ) Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores.The Biochemical journal, , 301 ( Pt 3) ,879-83 More Information

Cheek, T R; Moreton, R B; Berridge, M J; Stauderman, K A; Murawsky, M M; Bootman, M D (1993. ) Quantal Ca2+ release from caffeine-sensitive stores in adrenal chromaffin cells. The Journal of biological chemistry, , 268 (36 ) ,27076-83

Stauderman, K A; Murawsky, M M (1991. ) The inositol 1,4,5-trisphosphate-forming agonist histamine activates a ryanodine-sensitive Ca2+ release mechanism in bovine adrenal chromaffin cells. The Journal of biological chemistry, , 266 (29 ) ,19150-3

Stauderman, K A; McKinney, R A; Murawsky, M M (1991. ) The role of caffeine-sensitive Ca2+ stores in agonist- and inositol 1,4,5-trisphosphate-induced Ca2+ release from bovine adrenal chromaffin cells.The Biochemical journal, , 278 ( Pt 3) ,643-50 More Information

Stauderman, K A; Murawsky, M M; Pruss, R M (1990. ) Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release.Cell regulation, , 1 (9 ) ,683-91 More Information

Suszkiw, J B; Murawsky, M M; Shi, M (1989. ) Further characterization of phasic calcium influx in rat cerebrocortical synaptosomes: inferences regarding calcium channel type(s) in nerve endings.Journal of neurochemistry, , 52 (4 ) ,1260-9 More Information

Suszkiw, J B; Murawsky, M M; Fortner, R C (1987. ) Heterogeneity of presynaptic calcium channels revealed by species differences in the sensitivity of synaptosomal 45Ca entry to omega-conotoxin.Biochemical and biophysical research communications, , 145 (3 ) ,1283-6 More Information

Suszkiw, J B; O'Leary, M E; Murawsky, M M; Wang, T (1986. ) Presynaptic calcium channels in rat cortical synaptosomes: fast-kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 6 (5 ) ,1349-57

Suszkiw, J; Toth, G; Murawsky, M; Cooper, G P (1984. ) Effects of Pb2+ and Cd2+ on acetylcholine release and Ca2+ movements in synaptosomes and subcellular fractions from rat brain and Torpedo electric organ.Brain research, , 323 (1 ) ,31-46 More Information