Michael Murawsky

M.S.: COM, University of Cincinnati Cincinnati, OH, 1990 (Physiology / Biophysics)

B.S.: Bowling Green State University Bowling Green, OH, 1980 (Microbiology / Chemistry)

1980 -1983 Research Assistant Dept of Biochemistry, COM, University of Virginia, Charlottesville, VA

1983 -1988 Research Assistant Physiology & Biophysics, COM, University of Cincinnati, Cincinnati, OH

1988 -1996 Research Neurophysiologist, Cerebrovascular Diseases, Marion Merrell Dow Pharmaceuticals, Cincinnati, OH

1996 -2005 Associate Research Scientist, Cardiac Research, Procter and Gamble Pharmaceuticals, Cincinnati, OH

2005 - Sr. Research Assistant, COP, University of Cincinnati, Cincinnati, OH

Peer Reviewed Publications

Zhang, Qian; Murawsky, Michael; LaCount, Terri D; Hao, Jinsong; Ghosh, Priyanka; Raney, Sam G; Kasting, Gerald B; Li, S Kevin  (2020). Evaluation of Heat Effects on Fentanyl Transdermal Delivery Systems Using In Vitro Permeation and In Vitro Release Methods. Journal of pharmaceutical sciences, 109 (10) , 3095-3104More Information

La Count, Terri D; Zhang, Qian; Murawsky, Michael; Hao, Jinsong; Ghosh, Priyanka; Dave, Kaushalkumar; Raney, Sam G; Talattof, Arjang; Kasting, Gerald B; Li, S Kevin  (2020). Evaluation of Heat Effects on Transdermal Nicotine Delivery In Vitro and In Silico Using Heat-Enhanced Transport Model Analysis. The AAPS journal, 22 (4) , 82More Information

Ren, Wei; Murawsky, Michael; La Count, Terri; Wanasathop, Apipa; Hao, Xin; Kelm, Gary R; Kozak, Darby; Qin, Bin; Li, S Kevin  (2019). Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket. The AAPS journal, 21 (3) , 51More Information

Murawsky, Michael; Kelm, Gary R; Kozak, Darby; Qin, Bin; Zou, Yuan; Li, S Kevin  (2019). Influencing factors on gelatin matrix for chlorhexidine delivery. Drug development and industrial pharmacy, 45 (2) , 314-322More Information

Zhang, Qian; Murawsky, Michael; LaCount, Terri; Kasting, Gerald B; Li, S Kevin  (2018). Transepidermal water loss and skin conductance as barrier integrity tests. Toxicology in vitro : an international journal published in association with BIBRA, 51, 129-135More Information

Zhang, Qian; Murawsky, Michael; LaCount, Terri; Hao, Jinsong; Kasting, Gerald B; Newman, Bryan; Ghosh, Priyanka; Raney, Sam G; Li, S Kevin  (2017). Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro. Pharmaceutical research, 34 (7) , 1491-1504More Information

Christensen, Heather R; Murawsky, Michael K; Horseman, Nelson D; Willson, Tara A; Gregerson, Karen A  (2013). Completely humanizing prolactin rescues infertility in prolactin knockout mice and leads to human prolactin expression in extrapituitary mouse tissues. Endocrinology, 154 (12) , 4777-89More Information

Christensen, Heather R; Zeng, Qinghua; Murawsky, Michael K; Gregerson, Karen A  (2011). Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle. American journal of physiology. Regulatory, integrative and comparative physiology, 301 (3) , R746-56More Information

Jackson, Chris M; Blass, Benjamin; Coburn, Keith; Djandjighian, Laurent; Fadayel, Gina; Fluxe, Andrew J; Hodson, Steven J; Janusz, John M; Murawsky, Michael; Ridgeway, James M; White, Ronald E; Wu, Shengde  (2007). Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorganic & medicinal chemistry letters, 17 (1) , 282-4More Information

Wu, Shengde; Fluxe, Andrew; Sheffer, Jim; Janusz, John M; Blass, Benjamin E; White, Ron; Jackson, Chris; Hedges, Richard; Murawsky, Michael; Fang, Bin; Fadayel, Gina M; Hare, Michelle; Djandjighian, Laurent  (2006). Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers. Bioorganic & medicinal chemistry letters, 16 (24) , 6213-8More Information

Fluxe, Andrew; Wu, Shengde; Sheffer, James B; Janusz, John M; Murawsky, Michael; Fadayel, Gina M; Fang, Bin; Hare, Michelle; Djandjighian, Laurent  (2006). Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers. Bioorganic & medicinal chemistry letters, 16 (22) , 5855-8More Information

Wu, Shengde; Fluxe, Andrew; Janusz, John M; Sheffer, James B; Browning, Greg; Blass, Benjamin; Cobum, Keith; Hedges, Richard; Murawsky, Michael; Fang, Bin; Fadayel, Gina M; Hare, Michelle; Djandjighian, Laurent  (2006). Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers. Bioorganic & medicinal chemistry letters, 16 (22) , 5859-63More Information

Blass, Benjamin E; Coburn, Keith; Lee, Wenlin; Fairweather, Neil; Fluxe, Andrew; Wu, Shengde; Janusz, John M; Murawsky, Michael; Fadayel, Gina M; Fang, Bin; Hare, Michelle; Ridgeway, Jim; White, Ron; Jackson, Chris; Djandjighian, Laurent; Hedges, Richard; Wireko, Fred C; Ritter, Amanda L  (2006). Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation. Bioorganic & medicinal chemistry letters, 16 (17) , 4629-32More Information

Matsuno, Nobunaka; Murawsky, Michael; Ridgeway, James; Cuppoletti, John  (2004). Solid support membranes for ion channel arrays and sensors: application to rapid screening of pharmacological compounds. Biochimica et biophysica acta, 1665 (1-2) , 184-90More Information

Rampe, D; Murawsky, M K; Grau, J; Lewis, E W  (1998). The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG. The Journal of pharmacology and experimental therapeutics, 286 (2) , 788-93

Wible, B; Murawsky, M K; Crumb, W J; Rampe, D  (1997). Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents. Brain research, 761 (1) , 42-50More Information

Rampe, D; Murawsky, M K  (1997). Blockade of the human cardiac K+ channel Kv1.5 by the antibiotic erythromycin. Naunyn-Schmiedeberg's archives of pharmacology, 355 (6) , 743-50More Information

Baron, B M; Harrison, B L; Kehne, J H; Schmidt, C J; van Giersbergen, P L; White, H S; Siegel, B W; Senyah, Y; McCloskey, T C; Fadayel, G M; Taylor, V L; Murawsky, M K; Nyce, P; Salituro, F G  (1997). Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. European journal of pharmacology, 323 (2-3) , 181-92More Information

Cheek, T R; Murawsky, M M; Stauderman, K A  (1994). Histamine-induced Ca2+ entry precedes Ca2+ mobilization in bovine adrenal chromaffin cells. The Biochemical journal, 304 ( Pt 2), 469-76More Information

Cheek, T R; Berridge, M J; Moreton, R B; Stauderman, K A; Murawsky, M M; Bootman, M D  (1994). Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores. The Biochemical journal, 301 ( Pt 3), 879-83More Information

Cheek, T R; Moreton, R B; Berridge, M J; Stauderman, K A; Murawsky, M M; Bootman, M D  (1993). Quantal Ca2+ release from caffeine-sensitive stores in adrenal chromaffin cells. The Journal of biological chemistry, 268 (36) , 27076-83

Stauderman, K A; Murawsky, M M  (1991). The inositol 1,4,5-trisphosphate-forming agonist histamine activates a ryanodine-sensitive Ca2+ release mechanism in bovine adrenal chromaffin cells. The Journal of biological chemistry, 266 (29) , 19150-3

Stauderman, K A; McKinney, R A; Murawsky, M M  (1991). The role of caffeine-sensitive Ca2+ stores in agonist- and inositol 1,4,5-trisphosphate-induced Ca2+ release from bovine adrenal chromaffin cells. The Biochemical journal, 278 ( Pt 3), 643-50More Information

Stauderman, K A; Murawsky, M M; Pruss, R M  (1990). Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release. Cell regulation, 1 (9) , 683-91More Information

Suszkiw, J B; Murawsky, M M; Shi, M  (1989). Further characterization of phasic calcium influx in rat cerebrocortical synaptosomes: inferences regarding calcium channel type(s) in nerve endings. Journal of neurochemistry, 52 (4) , 1260-9More Information

Suszkiw, J B; Murawsky, M M; Fortner, R C  (1987). Heterogeneity of presynaptic calcium channels revealed by species differences in the sensitivity of synaptosomal 45Ca entry to omega-conotoxin. Biochemical and biophysical research communications, 145 (3) , 1283-6More Information

Suszkiw, J B; O'Leary, M E; Murawsky, M M; Wang, T  (1986). Presynaptic calcium channels in rat cortical synaptosomes: fast-kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 6 (5) , 1349-57

Suszkiw, J; Toth, G; Murawsky, M; Cooper, G P  (1984). Effects of Pb2+ and Cd2+ on acetylcholine release and Ca2+ movements in synaptosomes and subcellular fractions from rat brain and Torpedo electric organ. Brain research, 323 (1) , 31-46More Information