Masato Nakafuku , MD,PhD

Nakafuku Lab Overview Masato Nakafuku MD, PhD Research in the Nakafuku Laboratory centers on development and regeneration of the central nervous system (CNS). We are seeking to understand the molecular and cellular mechanisms underlying normal development of the CNS and advancing our knowledge of neural development to devise new therapeutic strategies to cure neurological diseases. These two research fields are directly related to each other, and neural stem cells are the key with which to link them in our research activities. Our laboratory belongs to the Molecular and Developmental Biology Graduate Program, Neuroscience Graduate Program, and the MD, PhD Program in The University of Cincinnati College of Medicine. We offer pre- and post-doctoral trainings through these programs. We also have programs for the training of basic neuroscience researchers (both fellows and residents) in clinical departments. Inquiries from interested trainees are always welcome. Contact Us The Nakafuku Laboratory is part of the Division of Developmental Biology at Cincinnati Children's Hospital Medical Center. The lab is located in Location R (Research Foundation Building), Room 2556. For more information, contact Masato Nakafuku, 513-636-9889 (masato.nakafuku@cchmc.org).

Grant: #SRS003506 Investigators:Nakafuku, Masato 08-01-2003 -06-30-2010 Ohio Board of Regents OBR/Ohio Eminent Scholar Developmental Neurobiology Role:PI $500,000.00 Active Level:State of Ohio

Peer Reviewed Publications

Shereen, Ahmed; Nemkul, Niza; Yang, Dianer; Adhami, Faisal; Dunn, R Scott; Hazen, Missy L; Nakafuku, Masato; Ning, Gang; Lindquist, Diana M; Kuan, Chia-Yi (2011. ) Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , 31 (4 ) ,1155-69 More Information

Zhong, Jingyang; Kim, Hyoung-Tai; Lyu, Jungmook; Yoshikawa, Kazuaki; Nakafuku, Masato; Lu, Wange (2011. ) The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.Development (Cambridge, England), , 138 (3 ) ,409-19 More Information

Pei, Zhenglei; Wang, Bei; Chen, Gang; Nagao, Motoshi; Nakafuku, Masato; Campbell, Kenneth (2011. ) Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation.Proceedings of the National Academy of Sciences of the United States of America, , 108 (4 ) ,1675-80 More Information

Nagao, Motoshi; Campbell, Kenneth; Burns, Kevin; Kuan, Chia-Yi; Trumpp, Andreas; Nakafuku, Masato (2008. ) Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.The Journal of cell biology, , 183 (7 ) ,1243-57 More Information

Sugimori, Michiya; Nagao, Motoshi; Parras, Carlos M; Nakatani, Hiroko; Lebel, Mélanie; Guillemot, François; Nakafuku, Masato (2008. ) Ascl1 is required for oligodendrocyte development in the spinal cord.Development (Cambridge, England), , 135 (7 ) ,1271-81 More Information

Nakafuku, Masato; Nagao, Motoshi; Grande, Andrew; Cancelliere, Alessandro (2008. ) Revisiting neural stem cell identity.Proceedings of the National Academy of Sciences of the United States of America, , 105 (3 ) ,829-30 More Information

Nagao, Motoshi; Sugimori, Michiya; Nakafuku, Masato (2007. ) Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells.Molecular and cellular biology, , 27 (11 ) ,3982-94 More Information

Parras, Carlos M; Hunt, Charles; Sugimori, Michiya; Nakafuku, Masato; Rowitch, David; Guillemot, François (2007. ) The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 27 (16 ) ,4233-42 More Information

Sugimori, Michiya; Nagao, Motoshi; Bertrand, Nicolas; Parras, Carlos M; Guillemot, François; Nakafuku, Masato (2007. ) Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord.Development (Cambridge, England), , 134 (8 ) ,1617-29 More Information

Kim, Hyun-Jung; Sugimori, Michiya; Nakafuku, Masato; Svendsen, Clive N (2007. ) Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1.Experimental neurology, , 203 (2 ) ,394-405 More Information

Ohori, Yasuo; Yamamoto, Shin-ichi; Nagao, Motoshi; Sugimori, Michiya; Yamamoto, Naoya; Nakamura, Kozo; Nakafuku, Masato (2006. ) Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (46 ) ,11948-60 More Information

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi (2006. ) Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.Proceedings of the National Academy of Sciences of the United States of America, , 103 (44 ) ,16520-5 More Information

Patten, Brooke A; Sardi, S Pablo; Koirala, Samir; Nakafuku, Masato; Corfas, Gabriel (2006. ) Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (12 ) ,3102-8 More Information

Kriks, Sonja; Lanuza, Guillermo M; Mizuguchi, Rumiko; Nakafuku, Masato; Goulding, Martyn (2005. ) Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord.Development (Cambridge, England), , 132 (13 ) ,2991-3002 More Information

Azuma, Noriyuki; Tadokoro, Keiko; Asaka, Astuko; Yamada, Masao; Yamaguchi, Yuki; Handa, Hiroshi; Matsushima, Satsuki; Watanabe, Takashi; Kida, Yasuyuki; Ogura, Toshihiko; Torii, Masaaki; Shimamura, Kenji; Nakafuku, Masato (2005. ) Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor.Human molecular genetics, , 14 (8 ) ,1059-68 More Information

Azuma, Noriyuki; Tadokoro, Keiko; Asaka, Astuko; Yamada, Masao; Yamaguchi, Yuki; Handa, Hiroshi; Matsushima, Satsuki; Watanabe, Takashi; Kohsaka, Shinichi; Kida, Yasuyuki; Shiraishi, Tomoki; Ogura, Toshihiko; Shimamura, Kenji; Nakafuku, Masato (2005. ) The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure.Human molecular genetics, , 14 (6 ) ,735-45 More Information

Oishi, Koji; Kamakura, Sachiko; Isazawa, Yuko; Yoshimatsu, Takeshi; Kuida, Keisuke; Nakafuku, Masato; Masuyama, Norihisa; Gotoh, Yukiko (2004. ) Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.Developmental biology, , 276 (1 ) ,172-84 More Information

Parras, Carlos M; Galli, Rossella; Britz, Olivier; Soares, Sylvia; Galichet, Christophe; Battiste, James; Johnson, Jane E; Nakafuku, Masato; Vescovi, Angelo; Guillemot, François (2004. ) Mash1 specifies neurons and oligodendrocytes in the postnatal brain.The EMBO journal, , 23 (22 ) ,4495-505 More Information

Kamakura, Sachiko; Oishi, Koji; Yoshimatsu, Takeshi; Nakafuku, Masato; Masuyama, Norihisa; Gotoh, Yukiko (2004. ) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.Nature cell biology, , 6 (6 ) ,547-54 More Information

Hu, Qi-Dong; Ang, Beng-Ti; Karsak, Meliha; Hu, Wei-Ping; Cui, Xiao-Ying; Duka, Tanya; Takeda, Yasuo; Chia, Wendy; Sankar, Natesan; Ng, Yee-Kong; Ling, Eng-Ang; Maciag, Thomas; Small, Deena; Trifonova, Radianna; Kopan, Raphael; Okano, Hideyuki; Nakafuku, Masato; Chiba, Shigeru; Hirai, Hisamaru; Aster, Jon C; Schachner, Melitta; Pallen, Catherine J; Watanabe, Kazutada; Xiao, Zhi-Cheng (2003. ) F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell, , 115 (2 ) ,163-75

Hashimoto-Torii, Kazue; Motoyama, Jun; Hui, Chi-Chung; Kuroiwa, Atsushi; Nakafuku, Masato; Shimamura, Kenji (2003. ) Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus. Mechanisms of development, , 120 (10 ) ,1097-111

Nakatomi, Hirofumi; Kuriu, Toshihiko; Okabe, Shigeo; Yamamoto, Shin-ichi; Hatano, Osamu; Kawahara, Nobutaka; Tamura, Akira; Kirino, Takaaki; Nakafuku, Masato (2002. ) Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell, , 110 (4 ) ,429-41

Kamitori, Kazuyo; Machide, Mitsuru; Tomita, Kazuhiko; Nakafuku, Masato; Kohsaka, Shinichi (2002. ) Cell-type-specific expression of protein tyrosine kinase-related receptor RYK in the central nervous system of the rat. Brain research. Molecular brain research, , 104 (2 ) ,255-66

Heins, Nico; Malatesta, Paolo; Cecconi, Francesco; Nakafuku, Masato; Tucker, Kerry Lee; Hack, Michael A; Chapouton, Prisca; Barde, Yves-Alain; Götz, Magdalena (2002. ) Glial cells generate neurons: the role of the transcription factor Pax6.Nature neuroscience, , 5 (4 ) ,308-15 More Information

Fu, Hui; Qi, Yingchuan; Tan, Min; Cai, Jun; Takebayashi, Hirohide; Nakafuku, Masato; Richardson, William; Qiu, Mengsheng (2002. ) Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development (Cambridge, England), , 129 (3 ) ,681-93

Kobayashi, Daisuke; Kobayashi, Makoto; Matsumoto, Ken; Ogura, Toshihiko; Nakafuku, Masato; Shimamura, Kenji (2002. ) Early subdivisions in the neural plate define distinct competence for inductive signals. Development (Cambridge, England), , 129 (1 ) ,83-93

Phone: 513-636-9389
masato.nakafuku@cchmc.org