Ramesh Nayak

Ramesh Chandra Nayak

Research Assistant Professor

Hoxworth Center (4-5)

COM Hoxworth Blood Center - 0055

Professional Summary

Research in my laboratory is focused around understanding the epigenetic landscape and regulation of transcriptomic programs critical for quiescence, self-renewal and multi-lineage differentiation, and malignant transformation of hematopoietic stem cells and progenitors (HSC/Ps). In addition, we model hematopoietic disorder using patient derived and gene-edited isogenic iPSCs, and hematopoietic cells regeneration from directed differentiation of healthy donor iPSCs.
Our research in the area of normal HSC/P biology,  leukemic stem cells (LSCs), hematopoietic cell regeneration and disease modeling using iPSCs  have been published in peer reviewed journals including Journal of clinical investigation, Blood, Nature communications, Cell reports, Stem cells translational medicine and Leukemia.


MSc: Utkal University Odisha, India, 2000 (Botany (specialization-Plant Biochemistry))

PhD: Jawahar Lal University New Delhi, 2008 (Molecular and Cell Biology)

BSc: Utkal University Odisha, India, 1998 (Botany (Hons), Zoology, Chemistry)

Research Support

Grant: #CancerFreeKids (Nayak) Investigators:Nayak, Ramesh 01-01-2024 -12-31-2024 CancerFree Kids SATB2, a novel target to eradicate leukemic initiating cells (LIC) in B-cell acute lymphoblastic leukemia (B-ALL) Role:PI 50000.00 Hold Level:Non Profit

Investigators:RAMESH C Nayak 07-01-2014 -06-30-2016 AABB “Angiotensin in stem cell recruitment and mobilization” Role:PI 150,000 Completed Type:Fellowship


Peer Reviewed Publications

Menéndez-Gutiérrez, María Piedad; Porcuna, Jesús; Nayak, Ramesh; Paredes, Ana; Niu, Haixia; Núñez, Vanessa; Paranjpe, Aditi; Gómez, Manuel J; Bhattacharjee, Anukana; Schnell, Daniel J; Sánchez-Cabo, Fátima; Welch, John S; Salomonis, Nathan; Cancelas, Jose A; Ricote, Mercedes (2023. ) Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis.Blood, , 141 (6 ) ,592-608 More Information

Nayak, R C; Chang, K H; Singh, A K; Kotliar, M; Desai, M; Wellendorf, A M; Wunderlich, M; Bartram, J; Mizukawa, B; Cuadrado, M; Dexheimer, P; Barski, A; Bustelo, X R; Nassar, N N; Cancelas, J A (2022. ) Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis.Nature communications, , 13 (1 ) ,3056 More Information

Govindarajah, Vinothini; Lee, Jung-Mi; Solomon, Michael; Goddard, Bryan; Nayak, Ramesh; Nattamai, Kalpana; Geiger, Hartmut; Salomonis, Nathan; Cancelas, Jose A; Reynaud, Damien (2020. ) FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia.Blood advances, , 4 (21 ) ,5512-5526 More Information

Althoff, Mark J; Nayak, Ramesh C; Hegde, Shailaja; Wellendorf, Ashley M; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Q Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2020. ) Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.Blood, , 136 (16 ) ,1824-1836 More Information

Nayak, Ramesh C; Cancelas, Jose A (2019. ) Ubiquitination is not omnipresent in myeloid leukemia.Haematologica, , 104 (9 ) ,1694-1696 More Information

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A (2019. ) Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.Stem cells translational medicine, , 8 (6 ) ,557-567 More Information

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A (2019. ) The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.Nature communications, , 10 (1 ) ,46 More Information

Liu, Shutong; de Castro, Luis F; Jin, Ping; Civini, Sara; Ren, Jiaqiang; Reems, Jo-Anna; Cancelas, Jose; Nayak, Ramesh; Shaw, Georgina; O'Brien, Timothy; McKenna, David H; Armant, Myriam; Silberstein, Leslie; Gee, Adrian P; Hei, Derek J; Hematti, Peiman; Kuznetsov, Sergei A; Robey, Pamela G; Stroncek, David F (2017. ) Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers.Scientific reports, , 7 ,46731 More Information

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A (2015. ) Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.Nature communications, , 6 ,5914 More Information

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2014. ) p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.Cell reports, , 9 (6 ) ,2084-97 More Information

Nayak, Ramesh C; Chang, Kyung-Hee; Vaitinadin, Nataraja-Sarma; Cancelas, Jose A (2013. ) Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.Immunological reviews, , 256 (1 ) ,255-68 More Information

Raman, R; Kumar, R S; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, J A; Filippi, M-D (2013. ) p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.Leukemia, , 27 (11 ) ,2209-19 More Information

Taniguchi Ishikawa, E; Chang, K H; Nayak, R; Olsson, H A; Ficker, A M; Dunn, S K; Madhu, M N; Sengupta, A; Whitsett, J A; Grimes, H L; Cancelas, J A (2013. ) Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking.Nature communications, , 4 ,1660 More Information

Nayak, Ramesh C; Trump, Lisa R; Aronow, Bruce J; Myers, Kasiani; Mehta, Parinda; Kalfa, Theodosia; Wellendorf, Ashley M; Valencia, C Alexander; Paddison, Patrick J; Horwitz, Marshall S; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A (2015. ) Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.The Journal of clinical investigation, , 125 (8 ) ,3103-16 More Information

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S (2014. ) Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.Blood, , 123 (4 ) ,562-9 More Information

Nayak, Ramesh C; Keshava, Shiva; Esmon, Charles T; Pendurthi, Usha R; Rao, L Vijaya Mohan (2013. ) Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIa.PloS one, , 8 (3 ) ,e59304 More Information

Sen, Prosenjit; Nayak, Ramesh; Clark, Curtis A; Gopalakrishnan, Ramakrishnan; Esmon, Charles T; Pendurthi, Usha R; Rao, L Vijaya Mohan (2011. ) Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C.Blood, , 118 (9 ) ,2635-6 More Information

Dhiman, Rohan; Bandaru, Anuradha; Barnes, Peter F; Saha, Sudipto; Tvinnereim, Amy; Nayak, Ramesh C; Paidipally, Padmaja; Valluri, Vijaya Lakshmi; Rao, L Vijaya Mohan; Vankayalapati, Ramakrishna (2011. ) c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages.Journal of immunology (Baltimore, Md. : 1950), , 186 (3 ) ,1638-45 More Information

Kothari, Hema; Nayak, Ramesh C; Rao, L Vijaya Mohan; Pendurthi, Usha R (2010. ) Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption.Blood, , 115 (21 ) ,4273-83 More Information

Gopalakrishnan, R; Hedner, U; Ghosh, S; Nayak, R C; Allen, T C; Pendurthi, U R; Rao, L V M (2010. ) Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa).Journal of thrombosis and haemostasis : JTH, , 8 (2 ) ,301-10 More Information

Dhiman, Rohan; Indramohan, Mohanalaxmi; Barnes, Peter F; Nayak, Ramesh C; Paidipally, Padmaja; Rao, L Vijaya Mohan; Vankayalapati, Ramakrishna (2009. ) IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion.Journal of immunology (Baltimore, Md. : 1950), , 183 (10 ) ,6639-45 More Information

Nayak, Ramesh C; Sen, Prosenjit; Ghosh, Samit; Gopalakrishnan, Ramakrishnan; Esmon, Charles T; Pendurthi, Usha R; Rao, L Vijaya Mohan (2009. ) Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications.Blood, , 114 (9 ) ,1974-86 More Information

Sahasrabuddhe, Amogh A; Nayak, Ramesh C; Gupta, Chhitar M (2009. ) Ancient Leishmania coronin (CRN12) is involved in microtubule remodeling during cytokinesis.Journal of cell science, , 122 (Pt 10 ) ,1691-9 More Information

Nayak, Ramesh C; Sahasrabuddhe, Amogh A; Bajpai, Virendra K; Gupta, Chhitar M (2005. ) A novel homologue of coronin colocalizes with actin in filament-like structures in Leishmania.Molecular and biochemical parasitology, , 143 (2 ) ,152-64 More Information

Book Chapter

Daniel Gonzalez-Nieto, Kyung-Hee Chang, Ilaria Fasciani, Ramesh Nayak, Laura Fernandez-García, Luis C. Barrio, José A. Cancelas (2015 ) Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY .(pp. 27).Elsevier

Ramesh C. Nayak , Kyung-Hee Chang , and Jose A. Cancelas (2015 ) Regulation of the Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease The Cytoskeleton in Health and Disease .(pp. 63).Springer