Daniel W. W Nebert, MD.

Daniel W Nebert, MD
Professor Emeritus

Bachelor's Degree: Wesleyan University Middletown CT, 1960 (Biochemistry)

Medical Degree: Univ Oregon Med School Portland, OR, 1964 (Medicine)

Master's Degree: Univ Oregon Med School Portland, OR, 1964 (Biophysics)

Inter ship and Residency : UCLA Health Sciences Center Los Angeles, Ca, 1966 (Pediatrics)

Postdoctoral Fellowship: National Institute of Health Bethesda, MD, 1968 (Cancer research)

Genes encoding drug-metabolizing enzymes; CYP1A1 gene; Ecogenetics; Standardized gene nomenclature; Gene superfamilies; Human Ah receptor gene; Environmental toxicology; Teratology; Cancer research.

Grant: #R01 ES010416 Investigators:Nebert, Daniel 09-30-2006 -07-31-2012 National Institute of Environmental Health Sciences Molecular Genetics of CD II Induced Disease Role:PI $1,671,274.00 Closed Level:Federal

Grant: #R01-DE016325 Investigators:Nebert, Daniel 04-01-2006 -03-31-2010 National Institute of Dental and Craniofacial Research Human HNSCC: CYP1B1/1A1/1A2 and AHR Gene Polymorphisms Role:PI $759,288.00 Closed Level:Federal

Grant: #SRS 003421 Investigators:Nebert, Daniel 07-01-2003 -12-31-2008 National Institute of Child Health and Human Development Pediatric Pharmacology Research Unit (PPRU) Role:PI $158,464.00 Closed Level:Federal

Grant: #R01 ES014403 Investigators:Nebert, Daniel 02-17-2006 -01-31-2011 National Institute of Environmental Health Sciences PAHs: Balance of Detoxification vs Metabolic Activation Role:PI $1,401,278.00 Closed Level:Federal

Grant: #5-R01-ES-08147-09-A0-S0-E0 Investigators:Nebert, Daniel 12-01-2000 -11-30-2006 National Institute of Environmental Health Sciences CYP1A1 Gene and Environmental Toxicity Role:PI $2,508,695.00 Closed Level:Federal

Grant: #5-R01-AG-09235-09-A0-S0-E0 Investigators:Nebert, Daniel 09-01-1995 -07-31-2000 National Institute on Aging Oxidative Stress, Cell Death and the [Ah] Gene Battery Role:PI $1,191,963.00 Closed Level:Federal

Grant: #5-R01-ES-08147-04-A0-S0-E0 Investigators:Nebert, Daniel 08-01-1996 -07-31-2000 National Institute of Environmental Health Sciences Role of the CYP1A1 Gene in Environmental Toxicity Role:PI $799,855.00 Closed Level:Federal

Grant: #5-R01-ES-06321-10-A0-S0-E0 Investigators:Nebert, Daniel 04-15-1998 -03-31-2004 National Institute of Environmental Health Sciences Genotoxicity in Cypia 2-Deficient Transgenic Mice Role:PI $1,192,301.00 Closed Level:Federal

Grant: #5-R01-ES-07058-03-A0-S0-E0 Investigators:Nebert, Daniel 03-01-1996 -02-29-2000 National Institute of Environmental Health Sciences Transgenic Zebrafish: Sentinel for Aquatic Pollution Role:PI $446,743.00 Closed Level:Federal

Grant: #5-R01-ES-10416-05-A0-S0-E0 Investigators:Nebert, Daniel 05-01-2000 -04-30-2006 National Institute of Environmental Health Sciences Molecular Genetics of Cd Toxicity Role:PI $1,721,250.00 Closed Level:Federal

Grant: #R21 ES015335 Investigators:Nebert, Daniel 12-15-2007 -11-30-2010 National Institute of Environmental Health Sciences Genetic Differences in PCB-Induced Behavior Role:PI $438,193.00 Closed Level:Federal

Grant: #P30 ES006096-16A1 Investigators:Caruso, Joseph; Deka, Ranjan; Embi, Peter; Greis, Kenneth; Ho, Shuk Mei; Lemasters, Grace; Medvedovic, Mario; Meller, Jaroslaw; Nebert, Daniel; Pinney, Susan; Puga, Alvaro; Rohs, Amy; Woo, Daniel 04-01-2008 -03-31-2013 National Institute of Environmental Health Sciences Environmental Genetics Role:Collaborator $8,028,782.00 Active Level:Federal

Grant: #T32 ES016646 Investigators:Nebert, Daniel 07-01-2008 -06-30-2014 National Institute of Environmental Health Sciences Gene-Environment Interaction Training Program Role:PI $1,861,830.00 Active Level:Federal

Grant: #R01 ES010807 Investigators:Nebert, Daniel; Puga, Alvaro; Xia, Ying 01-06-2011 -12-31-2015 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $1,347,002.00 Active Level:Federal

Peer Reviewed Publications

McDermott J.;Geng X.;Jiang L.;Gálvez-Peralta M.;Chen F.;Nebert D.;Liu Z.  (06-07-2016). Zinc-and bicarbonate-dependent ZIP8 transporter mediates selenite uptake. Oncotarget, 7 (23) , 35327-35340More Information

Nebert D.;Ingelman-Sundberg M.  (03-01-2016). What do animal experiments tell us that in vitro systems cannot? The Human Toxome Project. Regulatory Toxicology and Pharmacology, 75, 1-4More Information

Dong H.;Nebert D.;Bruford E.;Thompson D.;Joenje H.;Vasiliou V.  (11-24-2015). Update of the human and mouse Fanconi anemia genes. Human genomics, 9, 32More Information

Park J.H.;Hogrebe M.;Grüneberg M.;Duchesne I.;Von Der Heiden A.L.;Reunert J.;Schlingmann K.P.;Boycott K.M.;Beaulieu C.L.;Mhanni A.A.;Innes A.M.;Hörtnagel K.;Biskup S.;Gleixner E.M.;Kurlemann G.;Fiedler B.;Omran H.;Rutsch F.;Wada Y.;Tsiakas K.;Santer R.;Nebert D.W.;Rust S.;Marquardt T.  (12-03-2015). SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation. American Journal of Human Genetics, 97 (6) , 894-903More Information

Boycott K.M.;Beaulieu C.L.;Kernohan K.D.;Gebril O.H.;Mhanni A.;Chudley A.E.;Redl D.;Qin W.;Hampson S.;Küry S.;Tetreault M.;Puffenberger E.G.;Scott J.N.;Bezieau S.;Reis A.;Uebe S.;Schumacher J.;Hegele R.A.;McLeod D.R.;Gálvez-Peralta M.;Majewski J.;Ramaekers V.T.;Nebert D.W.;Innes A.M.;Parboosingh J.S.;Abou Jamra R.  (12-03-2015). Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of t. American Journal of Human Genetics, 97 (6) , 886-893More Information

Brocker C.; Gonzalez F.; Monte A.; Nebert D.; Thompson D.; Vasiliou V.  (01-01-2014). Improved drug therapy: triangulating phenomics with genomics and metabolomics. Human genomics, 8, 16More Information

Jorge-Nebert L.;Zhang G.;Wilson K.;Jiang Z.;Butler R.;Gluckman J.;Pinney S.;Nebert D.  (11-28-2016). Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and. Human Genomics, 10 (1) , 1-17More Information

Schiering C.;Wincent E.;Metidji A.;Iseppon A.;Li Y.;Potocnik A.J.;Omenetti S.;Henderson C.J.;Wolf C.R.;Nebert D.W.;Stockinger B.  (02-09-2017). Feedback control of AHR signalling regulates intestinal immunity. Nature, 542 (7640) , 242-245More Information

Zhang G.;Nebert D.  (07-01-2017). Personalized medicine: Genetic risk prediction of drug response. Pharmacology and Therapeutics, 175, 75-90More Information

Jorge-Nebert L.F.;Gálvez-Peralta M.;Landero Figueroa J.;Somarathna M.;Hojyo S.;Fukada T.;Nebert D.W.  (01-01-2015). Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated w. Toxicological sciences : an official journal of the Society of Toxicology, 143 (1) , 26-35More Information

Nebert D.W.  (07-01-2017). Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/P. Progress in Lipid Research, 67, 38-57More Information

Brocker C.;Carpenter C.;Nebert D.;Vasiliou V.  (08-01-2010). Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family. Human Genomics, 4 (6) , 411-420

Jackson B.C.;Nebert D.W.;Vasiliou V.  (01-01-2010). Update of human and mouse matrix metalloproteinase families. Human genomics, 4 (3) , 194-201

Jackson B.C.;Carpenter C.;Nebert D.W.;Vasiliou V.  (01-01-2010). Update of human and mouse forkhead box (FOX) gene families. Human genomics, 4 (5) , 345-352

Roberts R.;Nebert D.;Hickman J.;Richburg J.;Goldsworthy T.  (01-01-1997). Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology. Toxicological Sciences, 38 (2) , 107-115More Information

Guengerich F.; Juchau M.; Miller M.; Nebert D.; Raucy J.  (01-01-1996). Drug metabolic enzymes in developmental toxicology. Toxicological Sciences, 34 (2) , 165-175More Information

Wolf C.;Spurr N.;Nebert D.  (01-01-1992). Identification of genetic differences in debrisoquine hydroxylase activity. Hepatology, 15 (2) , 360-360More Information

Vasiliou V.;Liang H.;Puga A.;Nebert D.  (01-01-1992). Autoregulation Plus Negative And Positive Control of Murine Cypla-1 Gene Expression and the [Ah] Bat. Journal of Basic and Clinical Physiology and Pharmacology, 3 (Supplement) , 12More Information

Nebert D.  (01-01-1980). Pharmacogenetics: An approach to understanding chemical and biologic aspects of cancer. Journal of the National Cancer Institute, 64 (6) , 1279-1290More Information

Nebert D.  (08-22-1981). Clinical pharmacology: Possible clinical importance of genetic differences in drug metabolism. British Medical Journal (Clinical research ed.), 283 (6290) , 537More Information

Levitt R.;Fysh J.;Jensen N.;Nebert D.  (12-01-1979). The Ah locus: Biochemical basis for genetic differences in brain tumor formation in mice. Genetics, 92 (4) , 1205-1210

Pelkonen O.;Vahakangas K.;Nebert D.  (01-01-1980). Binding of polycyclic aromatic hydrocarbons to dna: Comparison with mutagenesis and tumorigenesis. Journal of Toxicology and Environmental Health, 6 (5-6) , 89-100More Information

Nebert D.;Shum S.  (01-01-1980). Reply to the letter of doctors Shepard and Fantel. Teratology, 22 (3) , 349-350More Information

Gene Superfamiles,Nomenclature,Pharmacogenetics,Pharmacogenomics

Academic - Dept Environ Health
31009 SW Country View Lane
Wilsonville  Oregon, 97070
Phone: 5036948482
dan.nebert@uc.edu