Simon L. Newman , PhD

Dr. Newman is a well-established investigator in macrophage function and has recently gained recognition for his expertise in studies of host defenses against fungi. His specific research interests involve analysis of the interaction of H. capsulatum yeasts and conidia with human monocytes, macrophages, neutrophils and dendritic cells. He is a past Associate Editor of The Journal of Immunology and an Editorial Board member of Infection and Immunity. He also is an ad hoc reviewer for The Journal of Experimental Medicine, The Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, USA, The Journal of Infectious Diseases, Medical Mycology, The American Journal of Pathology, American Review of Respiratory Disease, Arthritis and Rheumatism, The American Journal of Medical Sciences, Journal of Laboratory and Clinical Medicine, Kidney International, Natural Immunity and Blood. His published works include approximately 50 articles and approximately 60 abstracts.

Bachelor's Degree: Emory University Atlanta, Ga, 1969

Master's Degree: University of Alabama University Station, Al, 1971 (Cell and Molecular Biology)

Doctoral Degree: University of Alabama Medical Center Birmingham, Al, 1978 (Microbiology)

Postdoctoral Research Fellowship : National Jewish Hospital & Research Center Denver, CO , 1981 (Department of Pediatrics )

Postdoctoral Research Fellowship : University of North Carolina at Chapel Hill Chapel Hill, NC , 1982 (Rheumatology and Immunology )

The Role of Human Neutrophils, Monocyte/Macrophages and Dendritic Cells in Host Defense Against Medically Important Fungal Pathogens, Including Histoplasma Capsulatum, Candida Albicans, Blastomyces Dermatitidis and Cryptococcus Neoformans, Define the Role of Extracellular Matrix Proteins and Cytokines in Activating Macrophage Anti-Histoplasma Cctivity, Define the Interactions Between Dendritic Cells and Fungi as to Their Phagocytic Capacity and Ability to Present Fungal Antigens to T cells, and the Regulation of This Interaction by Co-Stimulatory Molecules and Cytokines.

1998 -To Present Professor, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH

1987 -1998 Associate Professor, (tenured, 1993) Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH

1982 -1987 Research Assistant Professor, Division of Rheumatology-Immunology, Department of Medicine and Department of Microbiology-Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC

1981 -1982 Postdoctoral Research Fellow, Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC

1978 -1981 Postdoctoral Research Fellow, Department of Pediatrics, National Jewish Hospital & Research Center, Denver, Colorado

1972 -1973 Assistant in Pathology, Department of Pathology, Tumor Biology Unit, University of Florida College of Medicine, Gainesville, Florida

1971 -1972 Research Assistant, Deparmtment of Pediatrics and Microbiology, University of Alabama Medical Center, Birmingham, Alabama

1969 -1971 Graduate Teaching Assistant, Department of Biology, University of Alabama, University Station, Alabama

Investigators:G. Deepe, SL Newman 04-01-2004 -03-31-2009 NIH, NIAID Defending against Systemic Mycoses. Project #1, Histoplasma capsulatum ligands for Dendritic Cell VLA-5 Role:P.I. $3,185,194

Investigators:S. Newman 07-01-1982 -06-30-1985 National Arthiritis Foundation Role of Complement Receptors in Macrophage Function Role:P.I. $69,000

Grant: #R23-CA36643 Investigators:S. Newman 09-01-1983 -08-31-1986 NIH,NCI New Invesigator of Research Award, Role of Complement in the Immunopathology of Macrophages Role:P.I. $107,500

Grant: #IM-308 Investigators:S. Newman, G. Ross 01-01-1982 -12-31-1986 American Cancer Society Research Grant Leukocyte Endogenous Complement and Complement Receptors Role:Co-I $208,000

Grant: #R01-CA25613 Investigators:G. Ross, S. Newman 09-01-1978 -08-31-1983 NIH, NCI Membrane Components of Normal and Leukemic Leukocytes Role:Co-I. $500,000

Grant: #2-R01-CA25613 Investigators:G. Ross, S. Newman 04-01-1984 -03-31-1987 NIH, NCI Membrane Components of Normal and Leukemic Leukocytes Role:Co-I. $350,000

Grant: #R01-AI23985 Investigators:S. Newman 06-01-1987 -05-31-1991 NIH, NIAID Receptor Function on Human Monocyte/Macrophages Role:P.I. $252,430

Grant: #2-R01-AI23985 Investigators:S. Newman, W. Bullock 09-30-1991 -08-31-1995 NIH, NIAID Immunoregulation in Disseminated Histoplasmosis Role:Co-I. $357,843

Grant: #R01-AI17339 Investigators:W. Bullock, S. Newman 12-31-1986 -11-30-1990 NIH, NIAID Immunoregulation in Disseminated Histoplasmosis Role:Co-I. $495,177

Investigators:S. Newman 06-01-1991 -05-31-1992 Biomedical Research Support Grant Host Defense Against Histoplasma capsulatum in AIDS Role:P.I. $10,000

Grant: #P01-AI28392 Investigators:W. Bullock, S. Newman 01-01-1990 -12-31-1994 NIH, NIAID Molecular and cell biology of fungal pathogens. Project #2, Interaction of H capsulatum with human macrophages Role:P.I. $2,103,626

Grant: #001523-11-RG Investigators:S. Newman 10-01-1991 -09-30-1993 American Foundation for AIDS Research Host Defense Against Histoplasma capsulatum in AIDS Role:P.I. $50,000

Grant: #R01-AI32368 Investigators:S. Newman 09-01-1993 -08-31-1996 NIH, NIAID Host defense against Histoplasma capsulatum in AIDS Role:P.I. $289,101

Grant: #HL-55948 Investigators:SL Newman 09-30-1995 -08-31-2000 NIH, NHLBI Interaction of H capsulatum with alveolar macrophages Role:P.I. $726,482

Grant: #AI-37639 Investigators:SL Newman 07-01-1996 -06-30-2001 NIH, NIAID Interaction of H. capsulatum with macrophages and PMN Role:P.I. $714,357

Grant: #AI49358 Investigators:SL Newman 07-01-2002 -06-30-2007 NIH, NIAID Interaction of H. capsulatum with Dendritic Cells Role:P.I. $1,125,000

Investigators:SL Newman 11-01-2010 -10-31-2011 Midwest Center for Emerging Infectious Diseases (MI-CEID) Histoplasma capsulatum as a vector for a TB vaccine Role:P.I. $30,000

Grant: #R01 AI049358 Investigators:Newman, Simon 06-15-2002 -05-31-2008 National Institute of Allergy and Infectious Diseases Interaction of H. Capsulatum with Dendritic Cells Role:PI $1,678,654.00 Closed Level:Federal

Grant: #5-R01-HL-55948-05-A0-S0-E0 Investigators:Newman, Simon 09-30-1995 -08-31-2001 National Heart, Lung and Blood Institute Interaction of H. Capsulatum with Alveolar Macrophages Role:PI $1,117,664.00 Closed Level:Federal

Grant: #5-R01-AI-37639-05-A0-S0-E0 Investigators:Newman, Simon 08-01-1996 -07-31-2002 National Institute of Allergy and Infectious Diseases Interaction of H. Capsulatum with Macrophages and PMN Role:PI $1,097,258.00 Closed Level:Federal

Grant: #R01 AI073337 Investigators:Deepe, George; Newman, Simon 06-01-2008 -05-31-2014 National Institute of Allergy and Infectious Diseases Immunopathogenesis in Histoplasmosis Role:Collaborator $1,978,701.00 Active Level:Federal

Grant: #HHSN2722010000291 Investigators:Cushion, Melanie; Newman, Simon; Rhodes, Judith; Smulian, Alan; Walzer, Peter 03-22-2010 -03-21-2017 National Institute of Allergy and Infectious Diseases Animal Models of Infectious Diseases Role:Collaborator $1,333,752.00 Active Level:Federal

Peer Reviewed Publications

Newman, Simon L; Lemen, Wendy; Smulian, Alan G (2011. ) Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts.Medical mycology : official publication of the International Society for Human and Animal Mycology, , 49 (4 ) ,356-64 More Information

Hilty, Jeremy; George Smulian, A; Newman, Simon L (2011. ) Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages.Medical mycology : official publication of the International Society for Human and Animal Mycology, , More Information

Gomez, Francisco J; Pilcher-Roberts, Robyn; Alborzi, Arash; Newman, Simon L (2008. ) Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. Journal of immunology (Baltimore, Md. : 1950), , 181 (10 ) ,7106-14

Hilty, Jeremy; Smulian, A George; Newman, Simon L (2008. ) The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.Molecular microbiology, , 70 (1 ) ,127-39 More Information

Newman, Simon L; Gootee, Lisa; Hilty, Jeremy; Morris, Randall E (2006. ) Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 176 (3 ) ,1806-13

Gildea, Lucy A; Ciraolo, Georgianne M; Morris, Randal E; Newman, Simon L (2005. ) Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion.Infection and immunity, , 73 (10 ) ,6803-11 More Information

Newman, Simon L; Bhugra, Bindu; Holly, Angela; Morris, Randal E (2005. ) Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion.Infection and immunity, , 73 (2 ) ,770-7 More Information

Newman, Simon L (2005. ) Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils.Methods in molecular medicine, , 118 ,181-91 More Information

Long, Kristin H; Gomez, Francisco J; Morris, Randall E; Newman, Simon L (2003. ) Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. Journal of immunology (Baltimore, Md. : 1950), , 170 (1 ) ,487-94

Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S (2011. ) HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.PLoS pathogens, , 7 (10 ) ,e1002330 More Information

1970 Sigma Xi Grant-in-Aid of Research Award

1979 Recipient of a Young Investigator Fellowship from the American Association for Clinical Immunology and Allergy

1982 -1985 Investigator of the National Arthritis Foundation

1983 -1986 New Investigator of Research Award from the National Cancer Institute, the National Institutes of Health

1993 Meritorious Achievement Award, Infectious Diseases Society of America

Immunology,Cell Differentiation,Phagocytosis,Cell Surface Receptor,Blood,Reticuloendothelial System,Cell,Blood Tissue Disease,Serum Complement,Infectious Disease,Medical Microbiology,Macrophages,Monocytes,Dendritic Cells,Fungi,Histoplasma Capsulatum,

Academic - Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0560
Phone: 513-558-4704
newmansl@ucmail.uc.edu

Office
Phone: 513-558-4709

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Phone: 513-558-4810