Liang Niu

Liang Niu

Associate Professor

Kettering Laboratory Room 143
160 Panzeca Way
Cincinnati, Ohio 45267
Phone 513-558-7221

Professional Summary

Liang Niu is a bioinformatician with emphasis in statistical methodologies/tools development. He got his doctoral training in mathematics and biostatistics at Ohio State University, and postdoctoral training in bioinformatics at NIH.


Bachelor's Degree: Hubei University 1997 (Mathematics)

Master's Degree: Peking University 2002 (Mathematics)

Doctoral Degree: Ohio State University 2008 (Mathematics)

Doctoral Degree: Ohio State University 2012 (Biostatistics)

Fellowship : National Institute of Environmental Health Sciences Durham, NC, 2015 ( Research Fellow)

Research and Practice Interests

1) Statistical bioinformatics (methodology): RNA-Seq, ChIA-PET, methylation array and PacBio sequencing; 2) Statistical bioinformatics (consulting): data analysis for RNA-Seq, ChIA-PET, methylation array, and mass spectrometry; 3) Biostatistical consulting: study planning and design, power calculations, and statistical modeling and analysis; 4) Data mining of public domain omics datasets (such as TCGA datasets).

Positions and Work Experience

2015 -2021 Assistant Professor, University of Cincinnati,

2021 -To Present Associate Professor, University of Cincinnati,

Research Support

Grant: #ES010807 Investigators:Biesiada, Jacek; Medvedovic, Mario; Niu, Liang; Puga, Alvaro; Xia, Ying 09-30-2017 -06-30-2022 National Institute of Environmental Health Sciences Molecular Mechanisms of Complex Mixture Toxicity Role:Collaborator $445,504.00 Awarded Level:Federal

Grant: #1R21CA241025-01 Investigators:Du, Chunying; Niu, Liang; Wang, Jiang 09-02-2019 -08-31-2021 National Institutes of Health Novel Targeting of Liver Cancer Deficient of DNA Repair Role:Collaborator $209,453.00 Awarded Level:Federal

Grant: #R01HD097597 Investigators:Burns, Katherine; Kasper, Susan; Niu, Liang 09-13-2019 -05-31-2024 National Institute of Child Health and Human Development The Role of the Matrisome in Endometriosis Development Role:Collaborator $439,549.00 Awarded Level:Federal

Grant: #137382 / DPIAI131080 Investigators:Niu, Liang 01-01-2020 -07-31-2021 National Institute of Allergy and Infectious Diseases IMMUNOLOGICAL IDENTITY REDEFINED BY GENETICALLY FOREIGN MICROCHIMERIC CELLS Role:PI $5,170.00 Awarded Level:Federal

Grant: #R01ES031054 Investigators:Brunst, Kelly; Niu, Liang 07-01-2020 -04-30-2025 National Institute of Environmental Health Sciences Epigenetics, air pollution, and childhood mental health Role:Collaborator $632,113.00 Awarded Level:Federal

Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 06-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:Collaborator 300615.48 Hold Level:Federal

Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:Collaborator 286061.00 Awarded Level:Federal

Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:Collaborator 286061.00 Active Level:Federal

Grant: #R01AG072592 Investigators:Hyacinth, Hyacinth; Niu, Liang; Sawyer, Russell 09-15-2021 -05-31-2026 National Institute on Aging Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer's disease and its related dementias (transfer application) Role:Collaborator 1505134.00 Awarded Level:Federal

Grant: #R01HL156024 Investigators:Hyacinth, Hyacinth; Niu, Liang 07-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease Role:Collaborator 918007.00 Active Level:Federal

Grant: #R01ES034049 Investigators:Mendy, Angelico; Niu, Liang 09-01-2022 -06-30-2025 National Institute of Environmental Health Sciences Childhood and In utero Exposure to Organophosphate and Replacement Brominated Flame Retardants and Child Respiratory Outcomes Role:Collaborator 310264.00 Awarded Level:Federal


Peer Reviewed Publications

Morrow, Ardythe L; McClain, Janelle; Conrey, Shannon C; Niu, Liang; Kinzer, Alexandra; Cline, Allison R; Piasecki, Alexandra M; DeFranco, Emily; Ward, Laura; Ware, Julie; Payne, Daniel C; Staat, Mary A; Nommsen-Rivers, Laurie A (2021. ) Breastfeeding Disparities and Their Mediators in an Urban Birth Cohort of Black and White Mothers.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, , 16 (6 ) ,452-462 More Information

Xu, Zongli; Xie, Changchun; Taylor, Jack A; Niu, Liang (2021. ) ipDMR: identification of differentially methylated regions with interval P-values.Bioinformatics (Oxford, England), , 37 (5 ) ,711-713 More Information

von Allmen, Douglas; Tang, Alice; Takiar, Vinita; Zender, Chad; Romeo, Stephen; Masch, Jessica; Casper, Keith; Patil, Yash; Wilson, Keith; Khosla, Siddarth; Niu, Liang; Altaye, Mekibib; Tabangin, Meredith; Howell, Rebecca J (2021. ) Modified Head and Neck Swallow Scale: Using EORTC-QLQ-H&N35 to Predict Overall Survival.The Laryngoscope, , More Information

Vilfranc, Chrystelle L; Che, Li-Xiao; Patra, Krushna C; Niu, Liang; Olowokure, Olugbenga; Wang, Jiang; Shah, Shimul A; Du, Chun-Ying (2021. ) BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.World journal of hepatology, , 13 (3 ) ,343-361 More Information

Morrow, Ardythe L; Staat, Mary A; DeFranco, Emily A; McNeal, Monica M; Cline, Allison R; Conrey, Shannon C; Schlaudecker, Elizabeth P; Piasecki, Alexandra M; Burke, Rachel M; Niu, Liang; Hall, Aron J; Bowen, Michael D; Gerber, Susan I; Langley, Gayle E; Thornburg, Natalie J; Campbell, Angela P; Vinjé, Jan; Parashar, Umesh D; Payne, Daniel C (2021. ) Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study.JMIR research protocols, , 10 (2 ) ,e22222 More Information

de Gannes, Matthew; Ko, Chia-I; Zhang, Xiang; Biesiada, Jacek; Niu, Liang; Koch, Sheryl E; Medvedovic, Mario; Rubinstein, Jack; Puga, Alvaro (2020. ) Dioxin Disrupts Dynamic DNA Methylation Patterns in Genes That Govern Cardiomyocyte Maturation.Toxicological sciences : an official journal of the Society of Toxicology, , 178 (2 ) ,325-337 More Information

Langevin, Scott M; Kuhnell, Damaris; Niu, Liang; Biesiada, Jacek; Leung, Yuet-Kin; Deka, Ranjan; Chen, Aimin; Medvedovic, Mario; Kelsey, Karl T; Kasper, Susan; Zhang, Xiang (2019. ) Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma.Epigenomics, , 11 (9 ) ,987-1002 More Information

Ge, Chunmin; Vilfranc, Chrystelle L; Che, Lixiao; Pandita, Raj K; Hambarde, Shashank; Andreassen, Paul R; Niu, Liang; Olowokure, Olugbenga; Shah, Shimul; Waltz, Susan E; Zou, Lee; Wang, Jiang; Pandita, Tej K; Du, Chunying (2019. ) The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.Hepatology (Baltimore, Md.), , 69 (6 ) ,2608-2622 More Information

Huang, Weichun; Medvedovic, Mario; Zhang, Jingwen; Niu, Liang (2019. ) ChIAPoP: a new tool for ChIA-PET data analysis.Nucleic acids research, , 47 (7 ) ,e37 More Information

Greene, Alexis D; Kendziorski, Jessica A; Buckholz, Jeanette M; Niu, Liang; Xie, Changchun; Pinney, Susan M; Burns, Katherine A (2019. ) Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.Reproductive toxicology (Elmsford, N.Y.), , 84 ,26-31 More Information

Haque, Sulsal-Ul; Niu, Liang; Kuhnell, Damaris; Hendershot, Jacob; Biesiada, Jacek; Niu, Wen; Hagan, Matthew C; Kelsey, Karl T; Casper, Keith A; Wise-Draper, Trisha M; Medvedovic, Mario; Langevin, Scott M (2018. ) Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma.Head & neck, , 40 (7 ) ,1555-1564 More Information

Leung, Yuet-Kin; Ouyang, Bin; Niu, Liang; Xie, Changchun; Ying, Jun; Medvedovic, Mario; Chen, Aimin; Weihe, Pal; Valvi, Damaskini; Grandjean, Philippe; Ho, Shuk-Mei (2018. ) Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort.Epigenetics, , 13 (3 ) ,290-300 More Information

Sharma, Manju; Zhang, Xiang; Zhang, Shuangmin; Niu, Liang; Ho, Shuk-Mei; Chen, Aimin; Huang, Shouxiong (2017. ) Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants.Scientific reports, , 7 (1 ) ,2085 More Information

Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R (2017. ) Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Cell reports, , 18 (9 ) ,2088-2095 More Information

Xu, Zongli; Langie, Sabine A S; De Boever, Patrick; Taylor, Jack A; Niu, Liang (2017. ) RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip.BMC genomics, , 18 (1 ) ,4 More Information

Xu, Zongli; Taylor, Jack A; Leung, Yuet-Kin; Ho, Shuk-Mei; Niu, Liang (2016. ) oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA.Bioinformatics (Oxford, England), , 32 (23 ) ,3667-3669 More Information

Niu, Liang; Xu, Zongli; Taylor, Jack A (2016. ) RCP: a novel probe design bias correction method for Illumina Methylation BeadChip.Bioinformatics (Oxford, England), , 32 (17 ) ,2659-63 More Information

Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying (2016. ) Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop.Protein & cell, , 7 (5 ) ,338-50 More Information

Xu, Zongli; Niu, Liang; Li, Leping; Taylor, Jack A (2016. ) ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip.Nucleic acids research, , 44 (3 ) ,e20 More Information

Dong, Jing; Yang, Jingyun; Tranah, Greg; Franceschini, Nora; Parimi, Neeta; Alkorta-Aranburu, Gorka; Xu, Zongli; Alonso, Alvaro; Cummings, Steven R; Fornage, Myriam; Huang, Xuemei; Kritchevsky, Stephen; Liu, Yongmei; London, Stephanie; Niu, Liang; Wilson, Robert S; De Jager, Philip L; Yu, Lei; Singleton, Andrew B; Harris, Tamara; Mosley, Thomas H; Pinto, Jayant M; Bennett, David A; Chen, Honglei (2015. ) Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.Medicine, , 94 (47 ) ,e1892 More Information

Niu, Liang; Lin, Shili (2015. ) A Bayesian mixture model for chromatin interaction data.Statistical applications in genetics and molecular biology, , 14 (1 ) ,53-64 More Information

Niu, Liang; Huang, Weichun; Umbach, David M; Li, Leping (2014. ) IUTA: a tool for effectively detecting differential isoform usage from RNA-Seq data.BMC genomics, , 15 ,862 More Information

Niu, Liang; Li, Guoliang; Lin, Shili (2014. ) Statistical models for detecting differential chromatin interactions mediated by a protein.PloS one, , 9 (5 ) ,e97560 More Information

Li, Yuanyuan; Huang, Weichun; Niu, Liang; Umbach, David M; Covo, Shay; Li, Leping (2013. ) Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes.BMC genomics, , 14 ,553 More Information

Sharma, Manju; Zhang, Shuangmin; Niu, Liang; Lewinsohn, David M; Zhang, Xiang; Huang, Shouxiong (2020. ) Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses.Frontiers in immunology, , 11 ,1136 More Information

Xueheng Zhao, Liang Niu, Carlo Clerici, Roberta Russo, Melissa Byrd, and Kenneth DR Setchell (2019. ) Data analysis of MS-based clinical lipidomics studies with crossover design: A tutorial mini-review of statistical methods .Clinical Mass Spectrometry, , 13 ,5-17

Cai Heng Li, Liang Niu, Akos Seress, Ronald Solomon (2010. ) The vertex primitive and vertex bi-primitive s-arc regular graphs .Journal of Combinatorial Theory, Series B, , 100 (4 ) ,359-366

Contact Information

Academic - Kettering Laboratory Room 143
160 Panzeca Way
Cincinnati  Ohio, 45267
Phone: 513-558-7221