Phillip Owens , PhD

Doctoral Degree: University of Kentucky 2009

The primary focus of my research is to examine the effects of coagulation proteins, proteases, and receptors in the pathogenesis cardiovascular disease (CVD), specifically atherosclerosis and abdominal aortic aneurysms (AAAs).  We utilize genetically modified mice and mouse models of disease to generate data and attempt to verify these results in the human condition, when possible, with retrospective clinical data or human specimens.  While several drug therapies exist for atherosclerosis, there are currently no pharmaceutical therapies for patients with AAA.  Further, even with modern pharmaceutical regiments for patients with coronary artery disease, it is still the leading cause of mortality. Therefore, the long-term goals of my work are to increase the understanding of thrombosis in atherosclerotic and aneurysmal disease and translate these findings into effective therapeutics to improve survival and quality of life for CVD patients.
 
Atherosclerotic disease is the leading cause of worldwide mortality with an estimated 7.4 million attributable deaths occurring in 2012. Abdominal aortic aneurysm (AAA) affects 5-10% of the male and female population over the age of 65 and is the 10th leading cause of death in the United States.  Histopathology of these two arterial diseases is similar with infiltrates of lipids, platelets, vascular smooth muscle cells (VSMC), macrophages (foam cells), T and B lymphocytes, and extracellular matrix resulting in severe inflammation. In atherosclerosis, cell and matrix deposition results in narrowed blood vessels and restricted blood flow leading to thrombus, ischemic stroke, or coronary occlusion; in AAA, such deposition results in a permanent localized dilatation in the arterial wall, formation of intramural clots, elastin and collagen destruction, and life-threatening aortic wall rupture. The fundamental connection between these two arterial diseases is the acute immune reaction to endogenous ligands, i.e. ‘sterile inflammation,’ and activation of the coagulation cascade.
 
 

Grant: #R00 HL116786 Investigators:Owens, Albert 03-15-2015 -02-28-2018 National Heart, Lung and Blood Institute Tissue Factor & Clot Formation in Abdominal Aortic Aneurysm Role:PI $348,937.00 Awarded Level:Federal

Grant: #R01HL141404 Investigators:Owens, Albert; Tranter, Michael 05-01-2018 -03-31-2023 National Heart, Lung and Blood Institute The role of protease-activated receptor 2 in atherosclerosis Role:PI $399,792.00 Awarded Level:Federal

Grant: #F31 HL143987 Investigators:Anderson, Heather; Owens, Albert; Russell, Hannah 09-01-2018 -08-31-2019 National Heart, Lung and Blood Institute Fibrin(ogen) in Abdominal Aortic Aneurysm Pathogenesis Role:Collaborator $37,205.00 Active Level:Federal

Grant: #5113140 Subaward Agreement Investigators:Owens, Albert 01-28-2019 -10-31-2019 Bayer AG Determine the Mechanism by which Rivaroxaban Reduces Atherosclerosis in LDLR-/-Mice Role:PI $64,000.00 Awarded Level:Industry

Grant: #19IPLOI34760319 Investigators:Owens, Albert 07-01-2019 -06-30-2021 American Heart Association - National Chapter The Role of Pulmonary Alveolar Microlithiasis in Cardiovascular Disease Role:PI $100,000.00 Awarded Level:Private Non-Profit

Grant: #R01HL147171 Investigators:Owens, Albert 06-01-2020 -05-31-2025 National Heart, Lung and Blood Institute Role of the Gut Microbiota in Abdominal Aortic Aneurysm Role:PI $658,278.85 Active Level:Federal

Grant: #CCHMC Billing Agreement / T32HL125204 Investigators:Benson, Tyler; Owens, Albert 06-01-2021 -05-31-2023 Cincinnati Children's Hospital Medical Center CCHMC -T32 Billing agreement for Tyler Benson Role:PI 70100.00 Hold Level:Non Profit

Grant: #SUB/R01HL158801 Investigators:Owens, Albert 07-01-2021 -06-30-2026 Cleveland Clinic The role of platelet olfactory receptors in abdominal aortic aneurysms Role:PI 39038.00 Hold Level:Non Profit

Grant: #R01HL158671 Investigators:Langevin, Scott; Owens, Albert; Tranter, Michael 08-01-2022 -06-30-2027 National Heart, Lung and Blood Institute Post-transcriptional control of adipose tissue gene expression as an endocrine mediator of cardiac pathology Role:Collaborator 656306.00 Awarded Level:Federal

Grant: #S10OD032249 Investigators:Owens, Albert 09-01-2022 -08-01-2023 Office of the Director, National Institutes of Health A Vevo 3100 Small Animal Ultrasound Machine for the University of Cincinnati Role:PI 409800.00 Awarded Level:Federal

Grant: #5R01HL147171-04 Investigators:Owens, Albert 06-01-2020 -05-30-2024 National Heart, Lung and Blood Institute Role of the Gut Microbiota in Abdominal Aortic Aneurysm Role:PI 0.00 Awarded Level:Federal

Grant: #NHLBI; F31HL170534 Investigators:Lee, Caris; Owens, Albert 09-30-2023 -09-29-2027 National Heart, Lung and Blood Institute The role of PAR2 and HuR in programming atherosclerotic vascular smooth muscle cells Role:PI 36165.00 Awarded Level:Federal

Grant: #CCHMC Billing agreement for Anthony Spuzzillo; T32HL125204-09 12-01-2023 -05-31-2024 National Heart, Lung and Blood Institute Spuzzillo Billing Agreement - T32HL125204-09 Role:PI 15737.00 Hold Level:Federal

Grant: #CCHMC Billing agreement for Anthony Spuzzillo; T32HL125204-09 12-01-2023 -05-31-2024 National Heart, Lung and Blood Institute Spuzzillo Billing Agreement - T32HL125204-09 Role:PI 15737.00 Hold Level:Federal

Peer Reviewed Publications

Sweet DT, Chen Z, Givens CS, Owens AP, Rojas M, Tzima E (2013. ) Endothelial Shc Regulates Arteriogenesis Through Dual Control of Arterial Specification and Inflammation via the Notch and NF-κB Pathways. Circulation Research, , 113 (1 ) ,32

Antoniak SA, Owens P, Baunacke M, Williams JC, Lee RD, Weithaeuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N (2013. ) PAR-1 Contributes to the Innate Immune Response During Viral Infection .The Journal of Clinical Investigation, , 123 (3 ) ,1310

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, Owens AP, Ware J, Kahn ML, Bergmeier W (2013. ) Platelet ITAM Signaling is Critical for Vascular Integrity in Inflammation. The Journal of Clinical Investigation, , 123 (2 ) ,908

Aruna Poduri, A. Phillip Owens III, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Lisa A. Cassis, and Alan Daugherty (2012. ) Regional Variation in Aortic AT1b Receptor mRNA Abundance is Associated with Contractility but Unrelated to Atherosclerosis and Aortic Aneurysms .PLoS One, , 7 (10 ) ,e48462

Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton J, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N (2012. ) Monocyte Tissue Factor-dependent Activation of coagulation in Hypercholesterolemic Mice and Monkeys is Inhibited by Simvastatin. .The Journal of Clinical Investigation, , 122 (2 ) ,558

Owens AP, Howatt DA, Moore KJ, Tobias PS, Curtiss LA, Cassis LA, Daugherty A (2011. ) MyD88 Deficiency Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm Formation Independent of Signaling Through Toll-like Receptors 2 and 4 .Arteriosclerosis, Thrombosis, and Vascular Biology, , 12 ,2813

Boulaftali, Yacine; Owens, A Phillip; Beale, Ashley; Piatt, Raymond; Casari, Caterina; Lee, Robert H; Conley, Pamela B; Paul, David S; Mackman, Nigel; Bergmeier, Wolfgang (2016. ) CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.Arteriosclerosis, thrombosis, and vascular biology, , 36 (5 ) ,792-9 More Information

Owens, A Phillip; Edwards, Todd L; Antoniak, Silvio; Geddings, Julia E; Jahangir, Eiman; Wei, Wei-Qi; Denny, Joshua C; Boulaftali, Yacine; Bergmeier, Wolfgang; Daugherty, Alan; Sampson, Uchechukwu K A; Mackman, Nigel (2015. ) Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.Arteriosclerosis, thrombosis, and vascular biology, , 35 (9 ) ,2032-41 More Information

Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens, A Phillip; Sparkenbaugh, Erica; Holle, Lori A; Wolberg, Alisa S; Kopec, Anna K; Pawlinski, Rafal; Luyendyk, James P; Mackman, Nigel (2016. ) Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.Journal of hepatology, , 64 (1 ) ,53-9 More Information

Østerud, B; Unruh, D; Olsen, J O; Kirchhofer, D; Owens, A P; Bogdanov, V Y (2015. ) Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.Journal of thrombosis and haemostasis : JTH, , 13 (9 ) ,1676-82 More Information

Kopec, Anna K; Abrahams, Sara R; Thornton, Sherry; Palumbo, Joseph S; Mullins, Eric S; Divanovic, Senad; Weiler, Hartmut; Owens, A Phillip; Mackman, Nigel; Goss, Ashley; van Ryn, Joanne; Luyendyk, James P; Flick, Matthew J (2017. ) Thrombin promotes diet-induced obesity through fibrin-driven inflammation.The Journal of clinical investigation, , 127 (8 ) ,3152-3166 More Information

Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael (2019. ) Human antigen R as a therapeutic target in pathological cardiac hypertrophy.JCI insight, , 4 (4 ) , More Information

Posma, Jens J; Grover, Steven P; Hisada, Yohei; Owens, A Phillip; Antoniak, Silvio; Spronk, Henri M; Mackman, Nigel (2019. ) Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases.Arteriosclerosis, thrombosis, and vascular biology, , 39 (1 ) ,13-24 More Information

Cameron, Scott J; Russell, Hannah M; Owens, A Phillip (2018. ) Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?.Blood, , 132 (25 ) ,2619-2628 More Information

Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack (2018. ) Tefillin use induces remote ischemic preconditioning pathways in healthy men.American journal of physiology. Heart and circulatory physiology, , 315 (6 ) ,H1748-H1758 More Information

Sundermann, Alexandra C; Saum, Keith; Conrad, Kelsey A; Russell, Hannah M; Edwards, Todd L; Mani, Kevin; Björck, Martin; Wanhainen, Anders; Owens, A Phillip (2018. ) Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth.Blood advances, , 2 (22 ) ,3088-3096 More Information

Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip (2018. ) PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.Arteriosclerosis, thrombosis, and vascular biology, , 38 (6 ) ,1271-1282 More Information

Saum K.;Campos B.;Celdran-Bonafonte D.;Nayak L.;Sangwung P.;Thakar C.;Roy-Chaudhury P.;Owens A. (01-01-2018. ) Uremic advanced glycation end products and protein-bound solutes induce endothelial dysfunction thro.Journal of the American Heart Association, , 7 (1 ) , More Information

Daugherty A.;Tall A.;Daemen M.;Falk E.;Fisher E.;García-Cardeña G.;Lusis A.;Owens A.;Rosenfeld M.;Virmani R. (09-01-2017. ) Recommendation on design, execution, and reporting of animal atherosclerosis studies: A scientific s.Circulation Research, , 121 (6 ) ,e53-e79 More Information

Daugherty A.;Tall A.R.;Daemen M.J.A.P.;Falk E.;Fisher E.A.;García-Cardeña G.;Lusis A.J.;Owens A.P.;Rosenfeld M.E.;Virmani R. (09-01-2017. ) Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific S.Arteriosclerosis, Thrombosis, and Vascular Biology, , 37 (9 ) ,e131-e157 More Information

Owens A.P.;MacKman N. (01-01-2012. ) Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque.Thrombosis Research, , 129 (SUPPL. 2 ) , More Information

Academic - Medical Sciences Building
231 Albert Sabin Way, MLC 0542
Cincinnati  Ohio, 45267
Phone: 513-558-3428
phillip.owens@uc.edu