Charlotte M Paquin

PhD: University of Michigan

My laboratory is studying primary gene amplification in the yeast Saccharomyces cerevisae. Primary gene amplification is the mutation from one gene per genome to two or more genes per genome. Gene amplification is important because it is the first step in the formation. My laboratory has developed a system to detect amplifications in the yeast Saccharomyces cerevisae.

Grant: #OSP 05-150 Investigators:Paquin, Charlotte 07-01-2004 -06-30-2005 National Institute of General Medical Sciences Faculty Research Support Role:PI $25,000.00 Closed Level:Federal

Peer Reviewed Publications

Peterson, C, Kordich, J, Milligan, L, Bodor, E, Siner, A, Nagy, K, & Paquin, C E (2000). Mutations in RAD3, MSH2, and RAD52 affect the rate of gene amplification in the yeast Saccharomyces cerevisiae. Environmental and molecular mutagenesis, 36(4), 325-34.

Moore, I K, Martin, M P, Dorsey, M J, & Paquin, C E (2000). Formation of circular amplifications in Saccharomyces cerevisiae by a breakage-fusion-bridge mechanism. Environmental and molecular mutagenesis, 36(2), 113-20.

Moore, I K, Martin, M P, & Paquin, C E (2000). Telomere sequences at the novel joints of four independent amplifications in Saccharomyces cerevisiae. Environmental and molecular mutagenesis, 36(2), 105-12.

Paquin, C E, Dorsey, M, Crable, S, Sprinkel, K, Sondej, M, & Williamson, V M (1992). A spontaneous chromosomal amplification of the ADH2 gene in Saccharomyces cerevisiae. Genetics, 130(2), 263-71.

Dorsey, M, Peterson, C, Bray, K, & Paquin, C E (1992). Spontaneous amplification of the ADH4 gene in Saccharomyces cerevisiae. Genetics, 132(4), 943-50.

Williamson, V M, & Paquin, C E (1987). Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis. Molecular & general genetics : MGG, 209(2), 374-81.

Walton, J D, Paquin, C E, Kaneko, K, & Williamson, V M (1986). Resistance to antimycin A in yeast by amplification of ADH4 on a linear, 42 kb palindromic plasmid. Cell, 46(6), 857-63.

Paquin, C E, & Williamson, V M (1986). Ty insertions at two loci account for most of the spontaneous antimycin A resistance mutations during growth at 15 degrees C of Saccharomyces cerevisiae strains lacking ADH1. Molecular and cellular biology, 6(1), 70-9.

Adams, J, Paquin, C, Oeller, P W, & Lee, L W (1985). Physiological characterization of adaptive clones in evolving populations of the yeast, Saccharomyces cerevisiae. Genetics, 110(2), 173-85.

Paquin, C E, & Williamson, V M (1984). Temperature effects on the rate of ty transposition. Science (New York, N.Y.), 226(4670), 53-5.More Information