Krushna Chandra Patra, PhD

Bachelor's Degree: Utkal University Orissa, India, 1999 (Botany)

Master's Degree: Indian Institute of Technology Kharagpur, India, 2004 (Applied Botany; Enzymology/Biotechnology)

Doctoral Degree: University of Illinois Chicago, IL, 2013 (Biochemistry and Molecular Genetics; Cancer metabolism, Cell signaling)

Residency: Harvard Medical School Boston, MA , 2019

Grant: #2020 PanCAN Career Development Award Investigators:Patra, Krushna 09-01-2020 -08-31-2022 Pancreatic Cancer Network Delineating oncogenic circuitries of GNAS mutant pancreatic neoplasms Role:PI $200,000.00 Active Level:Private Non-Profit

Grant: #K22CA237817 Investigators:Patra, Krushna 05-01-2021 -04-30-2024 National Cancer Institute Investigation of the mitochondrial function in GNAS mutant neoplasms Role:PI 195196.00 Awarded Level:Federal

Grant: #R01CA272854 Investigators:Patra, Krushna 08-01-2022 -07-31-2027 National Cancer Institute Investigating the molecular mechanisms of growth in GNAS mutant pancreatic cancer. Role:PI 370575.00 Awarded Level:Federal

Peer Reviewed Publications

Weerasekara, Vajira K; Patra, Krushna C; Bardeesy, Nabeel  (2019). EGFR Pathway Links Amino Acid Levels and Induction of Macropinocytosis. Developmental cell, 50 (3) , 261-263More Information

Goyal, Lipika; Shi, Lei; Liu, Leah Y; Fece de la Cruz, Ferran; Lennerz, Jochen K; Raghavan, Srivatsan; Leschiner, Ignaty; Elagina, Liudmila; Siravegna, Giulia; Ng, Raymond W S; Vu, Phuong; Patra, Krushna C; Saha, Supriya K; Uppot, Raul N; Arellano, Ron; Reyes, Stephanie; Sagara, Takeshi; Otsuki, Sachie; Nadres, Brandon; Shahzade, Heather A; Dey-Guha, Ipsita; Fetter, Isobel J; Baiev, Islam; Van Seventer, Emily E; Murphy, Janet E; Ferrone, Cristina R; Tanabe, Kenneth K; Deshpande, Vikram; Harding, James J; Yaeger, Rona; Kelley, Robin K; Bardelli, Alberto; Iafrate, A John; Hahn, William C; Benes, Cyril H; Ting, David T; Hirai, Hiroshi; Getz, Gad; Juric, Dejan; Zhu, Andrew X; Corcoran, Ryan B; Bardeesy, Nabeel  (2019). TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma. Cancer discovery, 9 (8) , 1064-1079More Information

Patra, Krushna C; Weerasekara, Vajira K; Bardeesy, Nabeel  (2019). AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth. Cell metabolism, 29 (2) , 238-240More Information

Hill, Margaret A; Alexander, William B; Guo, Bing; Kato, Yasutaka; Patra, Krushna; O'Dell, Michael R; McCall, Matthew N; Whitney-Miller, Christa L; Bardeesy, Nabeel; Hezel, Aram F  (2018). Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma. Cancer research, 78 (16) , 4445-4451More Information

Patra, Krushna C; Kato, Yasutaka; Mizukami, Yusuke; Widholz, Sebastian; Boukhali, Myriam; Revenco, Iulia; Grossman, Elizabeth A; Ji, Fei; Sadreyev, Ruslan I; Liss, Andrew S; Screaton, Robert A; Sakamoto, Kei; Ryan, David P; Mino-Kenudson, Mari; Castillo, Carlos Fernandez-Del; Nomura, Daniel K; Haas, Wilhelm; Bardeesy, Nabeel  (2018). Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nature cell biology, 20 (7) , 811-822More Information

Patra, Krushna C; Bardeesy, Nabeel  (2018). A Cell Size Theory of Aging. Developmental cell, 45 (6) , 665-666More Information

Nogueira, Veronique; Patra, Krushna C; Hay, Nissim  (2018). Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation. eLife, 7More Information

DeWaal, Dannielle; Nogueira, Veronique; Terry, Alexander R; Patra, Krushna C; Jeon, Sang-Min; Guzman, Grace; Au, Jennifer; Long, Christopher P; Antoniewicz, Maciek R; Hay, Nissim  (2018). Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature communications, 9 (1) , 446More Information

Patra, Krushna C; Bardeesy, Nabeel; Mizukami, Yusuke  (2017). Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm. Clinical and translational gastroenterology, 8 (4) , e86More Information

Yu, Wan-Ni; Nogueira, Veronique; Sobhakumari, Arya; Patra, Krushna C; Bhaskar, Prashanth T; Hay, Nissim  (2015). Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. Cell reports, 12 (4) , 610-21More Information

Patra, Krushna C; Hay, Nissim  (2014). The pentose phosphate pathway and cancer. Trends in biochemical sciences, 39 (8) , 347-54More Information

Patra, Krushna C; Hay, Nissim  (2013). Hexokinase 2 as oncotarget. Oncotarget, 4 (11) , 1862-3More Information

Patra, Krushna C; Wang, Qi; Bhaskar, Prashanth T; Miller, Luke; Wang, Zebin; Wheaton, Will; Chandel, Navdeep; Laakso, Markku; Muller, William J; Allen, Eric L; Jha, Abhishek K; Smolen, Gromoslaw A; Clasquin, Michelle F; Robey, Brooks; Hay, Nissim  (2013). Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer cell, 24 (2) , 213-228More Information

Roy, Nilotpal; Bommi, Prashant V; Bhat, Uppoor G; Bhattacharjee, Shaumick; Elangovan, Indira; Li, Jing; Patra, Krushna C; Kopanja, Dragana; Blunier, Adam; Benya, Richard; Bagchi, Srilata; Raychaudhuri, Pradip  (2013). DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer. Cancer research, 73 (12) , 3771-82More Information

Bhaskar, Prashanth T; Nogueira, Veronique; Patra, Krushna C; Jeon, Sang-Min; Park, Youngkyu; Robey, R Brooks; Hay, Nissim  (2009). mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Molecular and cellular biology, 29 (18) , 5136-47More Information

Banerjee, Rintu; Mukherjee, Gargi; Patra, Krushna Chandra  (2005). Microbial transformation of tannin-rich substrate to gallic acid through co-culture method. Bioresource technology, 96 (8) , 949-53More Information

Qiao, Shuxi; Koh, Siang-Boon; Vivekanandan, Varunika; Salunke, Devika; Patra, Krushna Chandra; Zaganjor, Elma; Ross, Kenneth; Mizukami, Yusuke; Jeanfavre, Sarah; Chen, Athena; Mino-Kenudson, Mari; Ramaswamy, Sridhar; Clish, Clary; Haigis, Marcia; Bardeesy, Nabeel; Ellisen, Leif W  (2020). REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors. Genes & developmentMore Information

Vilfranc, Chrystelle L; Che, Li-Xiao; Patra, Krushna C; Niu, Liang; Olowokure, Olugbenga; Wang, Jiang; Shah, Shimul A; Du, Chun-Ying  (2021). BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of ?-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis. World journal of hepatology, 13 (3) , 343-361More Information

Blaha, Catherine S; Ramakrishnan, Gopalakrishnan; Jeon, Sang-Min; Nogueira, Veronique; Rho, Hyunsoo; Kang, Soeun; Bhaskar, Prashanth; Terry, Alexander R; Aissa, Alexandre F; Frolov, Maxim V; Patra, Krushna C; Brooks Robey, R; Hay, Nissim  (2022). A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nature communications, 13 (1) , 899More Information

Bischoff, Megan E; Shamsaei, Behrouz; Yang, Juechen; Secic, Dina; Vemuri, Bhargav; Reisz, Julie A; D'Alessandro, Angelo; Bartolacci, Caterina; Adamczak, Rafal; Schmidt, Lucas; Wang, Jiang; Martines, Amelia; Biesiada, Jacek; Vest, Katherine E; Scaglioni, Pier P; Plas, David R; Patra, Krushna C; Gulati, Shuchi; Figueroa, Julio A Landero; Meller, Jarek; Cunningham, J Tom; Czyzyk-Krzeska, Maria F  (2024). Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma. bioRxiv : the preprint server for biologyMore Information

Chan, Gary K L; Maisel, Samantha; Hwang, Yeonjoo C; Pascual, Bryan C; Wolber, Rebecca R B; Vu, Phuong; Patra, Krushna C; Bouhaddou, Mehdi; Kenerson, Heidi L; Lim, Huat C; Long, Donald; Yeung, Raymond S; Sethupathy, Praveen; Swaney, Danielle L; Krogan, Nevan J; Turnham, Rigney E; Riehle, Kimberly J; Scott, John D; Bardeesy, Nabeel; Gordan, John D  (2023). Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms. eLife, 12More Information

Invited Presentations

(2018. ) Frontiers in RAS pathobiology and drug discovery, ASBMB meetings, Vermont, USA .

(2018. ) Harvard Medical School-PANC meeting, Boston, USA .

(2018. ) Tumor metabolism (A5), Keystone meetings. Snowbird, Utah, USA .

(2018. ) Barbados workshop on cancer epigenetics, Barbados .

(2013. ) Tumor metabolism (X4), Keystone meetings. Keystone, Colorado, USA .

(2012. ) Mechanisms and models of cancer, Cold Spring Harbor meetings, Newyork, USA .

2016 -2017 Department of Defense Post-doctoral Fellowship (PRCRP Horizon award), USA

2015 -2017 Andrew Warshaw Institute for Pancreatic Cancer Research Award, MGH, Boston, USA

2011 -2013 Department of Defense Pre-doctoral Fellowship(BCRP), USA

2003 -2004 Council of Science and Industrial Research NET/JRF Award, India

2002 -2003 All India Graduate Aptitude Test of Engineering Fellowship, India

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267-0521
Phone: (513) ‬‭558-3060
patraka@ucmail.uc.edu