Diego Perez-Tilve

Diego Perez-Tilve

Research Associate Professor

Education

Faculty of Sciences, University of Vigo Spain, 1998 (Biology)

Doctoral Degree: University of Vigo 2004 (Biological Sciences)

2004 -2009 Postdoctoral Fellowship : Obesity Research Center and Genome Research Institute, University of Cincinnati 2009 (Psychiatry)

Positions and Work Experience

2009 -To Present Research Assistant Professor, Division of Endocrinology, Diabetes & Metabolism, Unviersity of Cincinanti College of Medicine, Cincinnati, OH

Research Support

Grant: #R01 DK077975 Investigators:Hui, David; Obici, Silvana; Perez-Tilve, Diego; Stern, Javier; Tschoep, Matthias 01-15-2009 -12-31-2013 National Inst of Diabetes and Digestive and Kidney Disease Neuroendocrine Regulation of Adipocyte Metabolism Role:PI $1,747,173.00 Active Level:Federal

Grant: #Insulin Tests in Rodents Investigators:Perez-Tilve, Diego 01-01-2014 -12-31-2014 Calibrium Novel peptide-based therapies for the treatment of diabetes Role:PI $311,578.00 Active Level:Industry

Grant: #2017 ISRA Investigators:Perez-Tilve, Diego 01-01-2017 -12-31-2017 CohBar, Inc. Cohbar agreement 2017 Role:PI $376,583.00 Active Level:Industry

Grant: #2019 Industry Sponsored Agreement 08-07-2019 -08-07-2020 MBX Biosciences, Inc MBX Role:PI $275,720.00 Awarded Level:Industry

Grant: #2019 Industry Sponsored Agreement 08-07-2019 -08-07-2020 MBX Biosciences, Inc MBX Role:PI $275,720.00 Awarded Level:Industry

Grant: #2019 Sponsored Research Agreement Investigators:Perez-Tilve, Diego 01-01-2020 -12-31-2022 Novo Nordisk A/S Novel peptide-based therapies for the treatment of diabetes - 2019 agreement Role:PI $1,309,722.08 Awarded Level:Foreign Industry

Grant: #2020 Agreement_Continuation_Yr 2 Investigators:Perez-Tilve, Diego 08-08-2020 -08-08-2021 MBX Biosciences, Inc MBX Biosciences SPONSORED RESEARCH AGREEMENT Role:PI $305,171.00 Active Level:Industry

Publications

Peer Reviewed Publications

Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M (2011. ) CNS regulation of plasma cholesterol.Annals of medicine, , More Information

Perez-Tilve, Diego; Heppner, Kristy; Kirchner, Henriette; Lockie, Sarah H; Woods, Stephen C; Smiley, David L; Tschöp, Matthias; Pfluger, Paul (2011. ) Ghrelin-induced adiposity is independent of orexigenic effects.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , More Information

Pfluger, Paul T; Castañeda, Tamara R; Heppner, Kristy M; Strassburg, Sabine; Kruthaupt, Traci; Chaudhary, Nilika; Halem, Heather; Culler, Michael D; Datta, Rakesh; Burget, Lukas; Tschöp, M H; Nogueiras, Ruben; Perez-Tilve, Diego (2011. ) Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity.Physiology & behavior, , More Information

Patterson, James T; Ottaway, Nickki; Gelfanov, Vasily M; Smiley, David L; Perez-Tilve, Diego; Pfluger, Paul T; Tschöp, Matthias H; Dimarchi, Richard D (2011. ) A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.ACS chemical biology, , 6 (2 ) ,135-45 More Information

Müller, Timo D; Perez-Tilve, Diego; Tong, Jenny; Pfluger, Paul T; Tschöp, Matthias H (2010. ) Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia.Journal of cachexia, sarcopenia and muscle, , 1 (2 ) ,159-167 More Information

Strassburg, Sabine; Pfluger, Paul T; Chaudhary, Nilika; Tso, Patrick; Tschöp, Matthias H; Anker, Stefan D; Nogueiras, Ruben; Perez-Tilve, Diego (2010. ) Action profile of the antiobesity drug candidate oleoyl-estrone in rats.Obesity (Silver Spring, Md.), , 18 (12 ) ,2260-7 More Information

Horvath, Tamas L; Sarman, Beatrix; García-Cáceres, Cristina; Enriori, Pablo J; Sotonyi, Peter; Shanabrough, Marya; Borok, Erzsebet; Argente, Jesus; Chowen, Julie A; Perez-Tilve, Diego; Pfluger, Paul T; Brönneke, Hella S; Levin, Barry E; Diano, Sabrina; Cowley, Michael A; Tschöp, Matthias H (2010. ) Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity.Proceedings of the National Academy of Sciences of the United States of America, , 107 (33 ) ,14875-80 More Information

Heppner, Kristy M; Habegger, Kirk M; Day, Jonathan; Pfluger, Paul T; Perez-Tilve, Diego; Ward, Brian; Gelfanov, Vasily; Woods, Steve C; DiMarchi, Richard; Tschöp, Matthias (2010. ) Glucagon regulation of energy metabolism.Physiology & behavior, , 100 (5 ) ,545-8 More Information

Lee, Sang Jun; Kim, Ji Young; Nogueiras, Ruben; Linares, Juan F; Perez-Tilve, Diego; Jung, Dae Young; Ko, Hwi Jin; Hofmann, Susanna M; Drew, Angela; Leitges, Michael; Kim, Jason K; Tschöp, Matthias H; Diaz-Meco, Maria T; Moscat, Jorge (2010. ) PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance.Cell metabolism, , 12 (1 ) ,65-77 More Information

Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H (2010. ) Melanocortin signaling in the CNS directly regulates circulating cholesterol.Nature neuroscience, , 13 (7 ) ,877-82 More Information

Gil-Lozano, Manuel; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Martís, Aurelio; Fernandez, Ana M; Catalina, Pablo A F; Gonzalez-Matias, Lucas C; Mallo, Federico (2010. ) GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans.Endocrinology, , 151 (6 ) ,2629-40 More Information

Stefater, Margaret A; Pérez-Tilve, Diego; Chambers, Adam P; Wilson-Pérez, Hilary E; Sandoval, Darleen A; Berger, José; Toure, Mouhamadoul; Tschöp, Matthias; Woods, Stephen C; Seeley, Randy J (2010. ) Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity.Gastroenterology, , 138 (7 ) ,2426-36, 2436.e1-3 More Information

Pérez-Tilve, Diego; González-Matías, Lucas; Aulinger, Benedikt A; Alvarez-Crespo, Mayte; Gil-Lozano, Manuel; Alvarez, Elias; Andrade-Olivie, Amalia M; Tschöp, Matthias H; D'Alessio, David A; Mallo, Federico (2010. ) Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system.American journal of physiology. Endocrinology and metabolism, , 298 (5 ) ,E1088-96 More Information

Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H (2010. ) CNS leptin action modulates immune response and survival in sepsis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (17 ) ,6036-47 More Information

Sutton, Gregory M; Begriche, Karima; Kumar, K Ganesh; Gimble, Jeffrey M; Perez-Tilve, Diego; Nogueiras, Ruben; McMillan, Ryan P; Hulver, Matthew W; Tschöp, Matthias H; Butler, Andrew A (2010. ) Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 24 (3 ) ,862-72 More Information

Day, Jonathan W; Ottaway, Nickki; Patterson, James T; Gelfanov, Vasily; Smiley, David; Gidda, Jas; Findeisen, Hannes; Bruemmer, Dennis; Drucker, Daniel J; Chaudhary, Nilika; Holland, Jenna; Hembree, Jazzminn; Abplanalp, William; Grant, Erin; Ruehl, Jennifer; Wilson, Hilary; Kirchner, Henriette; Lockie, Sarah Haas; Hofmann, Susanna; Woods, Stephen C; Nogueiras, Ruben; Pfluger, Paul T; Perez-Tilve, Diego; DiMarchi, Richard; Tschöp, Matthias H (2009. ) A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.Nature chemical biology, , 5 (10 ) ,749-57 More Information

Nogueiras, Ruben; Pérez-Tilve, Diego; Veyrat-Durebex, Christelle; Morgan, Donald A; Varela, Luis; Haynes, William G; Patterson, James T; Disse, Emmanuel; Pfluger, Paul T; López, Miguel; Woods, Stephen C; DiMarchi, Richard; Diéguez, Carlos; Rahmouni, Kamal; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H (2009. ) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 29 (18 ) ,5916-25 More Information

Sutton, Gregory M; Perez-Tilve, Diego; Nogueiras, Ruben; Fang, Jidong; Kim, Jason K; Cone, Roger D; Gimble, Jeffrey M; Tschöp, Matthias H; Butler, Andrew A (2008. ) The melanocortin-3 receptor is required for entrainment to meal intake.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 28 (48 ) ,12946-55 More Information

Perez-Tilve, Diego; D'Alessio, David A; Tschöp, Matthias H (2008. ) A sweet spot for the bariatric surgeon.Cell metabolism, , 8 (3 ) ,177-9 More Information

Strassburg, Sabine; Anker, Stefan D; Castaneda, Tamara R; Burget, Lukas; Perez-Tilve, Diego; Pfluger, Paul T; Nogueiras, Ruben; Halem, Heather; Dong, Jesse Z; Culler, Michael D; Datta, Rakesh; Tschöp, Matthias H (2008. ) Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.American journal of physiology. Endocrinology and metabolism, , 295 (1 ) ,E78-84 More Information

Nogueiras, Ruben; López, Miguel; Lage, Ricardo; Perez-Tilve, Diego; Pfluger, Paul; Mendieta-Zerón, Hugo; Sakkou, Maria; Wiedmer, Petra; Benoit, Stephen C; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark; Vidal-Puig, Antonio; Horvath, Tamas; Treier, Mathias; Diéguez, Carlos; Tschöp, Matthias H (2008. ) Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.Endocrinology, , 149 (6 ) ,3009-15 More Information

López, Miguel; Lage, Ricardo; Saha, Asish K; Pérez-Tilve, Diego; Vázquez, María J; Varela, Luis; Sangiao-Alvarellos, Susana; Tovar, Sulay; Raghay, Kawtar; Rodríguez-Cuenca, Sergio; Deoliveira, Rosangela M; Castañeda, Tamara; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark W; Alvarez, Clara V; Gallego, Rosalía; Lelliott, Christopher J; Carling, David; Tschöp, Matthias H; Diéguez, Carlos; Vidal-Puig, Antonio (2008. ) Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.Cell metabolism, , 7 (5 ) ,389-99 More Information

Pfluger, Paul T; Kirchner, Henriette; Günnel, Susanne; Schrott, Brigitte; Perez-Tilve, Diego; Fu, Sheng; Benoit, Stephen C; Horvath, Tamas; Joost, Hans-Georg; Wortley, Katherine E; Sleeman, Mark W; Tschöp, Matthias H (2008. ) Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.American journal of physiology. Gastrointestinal and liver physiology, , 294 (3 ) ,G610-8 More Information

Tizzano, Joseph P; Stribling, D Sloan; Perez-Tilve, Diego; Strack, Alison; Frassetto, Andrea; Chen, Richard Z; Fong, Tung M; Shearman, Lauren; Krieter, Philip A; Tschöp, Matthias H; Skolnick, Phil; Basile, Anthony S (2008. ) The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.The Journal of pharmacology and experimental therapeutics, , 324 (3 ) ,1111-26 More Information

Hofmann, Susanna M; Perez-Tilve, Diego; Greer, Todd M; Coburn, Beth A; Grant, Erin; Basford, Joshua E; Tschöp, Matthias H; Hui, David Y (2008. ) Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.Diabetes, , 57 (1 ) ,5-12 More Information

Hofmann, Susanna M; Zhou, Li; Perez-Tilve, Diego; Greer, Todd; Grant, Erin; Wancata, Lauren; Thomas, Andrew; Pfluger, Paul T; Basford, Joshua E; Gilham, Dean; Herz, Joachim; Tschöp, Matthias H; Hui, David Y (2007. ) Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.The Journal of clinical investigation, , 117 (11 ) ,3271-82 More Information

Nogueiras, Ruben; Wiedmer, Petra; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Keogh, Julia M; Sutton, Gregory M; Pfluger, Paul T; Castaneda, Tamara R; Neschen, Susanne; Hofmann, Susanna M; Howles, Philip N; Morgan, Donald A; Benoit, Stephen C; Szanto, Ildiko; Schrott, Brigitte; Schürmann, Annette; Joost, Hans-Georg; Hammond, Craig; Hui, David Y; Woods, Stephen C; Rahmouni, Kamal; Butler, Andrew A; Farooqi, I Sadaf; O'Rahilly, Stephen; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H (2007. ) The central melanocortin system directly controls peripheral lipid metabolism.The Journal of clinical investigation, , 117 (11 ) ,3475-88 More Information

Nomiyama, Takashi; Perez-Tilve, Diego; Ogawa, Daisuke; Gizard, Florence; Zhao, Yue; Heywood, Elizabeth B; Jones, Karrie L; Kawamori, Ryuzo; Cassis, Lisa A; Tschöp, Matthias H; Bruemmer, Dennis (2007. ) Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.The Journal of clinical investigation, , 117 (10 ) ,2877-88 More Information

Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Mallo, Federico (2007. ) Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. Endocrine, , 31 (2 ) ,119-24

Pérez-Tilve, Diego; González-Matías, Lucas; Alvarez-Crespo, Mayte; Leiras, Roberto; Tovar, Sulay; Diéguez, Carlos; Mallo, Federico (2007. ) Exendin-4 potently decreases ghrelin levels in fasting rats.Diabetes, , 56 (1 ) ,143-51 More Information

Nogueiras, Rubén; Pfluger, Paul; Tovar, Sulay; Arnold, Myrtha; Mitchell, Sharon; Morris, Amanda; Perez-Tilve, Diego; Vázquez, Maria J; Wiedmer, Petra; Castañeda, Tamara R; DiMarchi, Richard; Tschöp, Matthias; Schurmann, Annette; Joost, Hans-Georg; Williams, Lynda M; Langhans, Wolfgang; Diéguez, Carlos (2007. ) Effects of obestatin on energy balance and growth hormone secretion in rodents.Endocrinology, , 148 (1 ) ,21-6 More Information

Theander-Carrillo, Claudia; Wiedmer, Petra; Cettour-Rose, Philippe; Nogueiras, Ruben; Perez-Tilve, Diego; Pfluger, Paul; Castaneda, Tamara R; Muzzin, Patrick; Schürmann, Annette; Szanto, Ildiko; Tschöp, Matthias H; Rohner-Jeanrenaud, Françoise (2006. ) Ghrelin action in the brain controls adipocyte metabolism.The Journal of clinical investigation, , 116 (7 ) ,1983-93 More Information

Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico (2006. ) Fibroblast growth factor-2 and epidermal growth factor modulate prolactin responses to TRH and dopamine in primary cultures.Endocrine, , 29 (2 ) ,317-24 More Information

Perez-Tilve, Diego; Stern, Javier E; Tschöp, Matthias (2006. ) The brain and the metabolic syndrome: not a wireless connection.Endocrinology, , 147 (3 ) ,1136-9 More Information

Perez-Tilve, Diego; Nogueiras, Ruben; Mallo, Federico; Benoit, Stephen C; Tschoep, Matthias (2006. ) Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine, , 29 (1 ) ,61-71

Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico (2004. ) Heparin increases prolactin and modifies the effects of fgf-2 upon prolactin accumulation in pituitary primary cultures.Endocrine, , 24 (2 ) ,131-6 More Information

Diz Chaves, Yolanda; Spuch Calvar, Carlos; Pérez Tilve, Diégo; Mallo Ferrer, Federico (2003. ) GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats. Life sciences, , 73 (26 ) ,3375-85

Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, (2014. ) Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. .Diabetes., , (63 ) ,122-131

Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. (2014. ) GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. Diabetes., , (63 ) ,505-13

Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. (2014. ) Hormones and diet, but not body weight, control hypothalamic microglial activity .Glia , , (62 ) ,17-25

Wilson-Perez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Perez-Tilve, D., and Seeley, R. J. (2013. ) Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. .Diabetes., , (62 ) ,2380-2385

Ward, B. P., Ottaway, N. L., Perez-Tilve, D., Ma, D., Gelfanov, V. M., Tschop, M. H., and Dimarchi, R. D (2013. ) Peptide lipidation stabilizes structure to enhance biological function. Molecular metabolism, , (2 ) ,468-479

Muller, T. D., Muller, A., Yi, C. X., Habegger, K. M., Meyer, C. W., Gaylinn, B. D., Finan, B., Heppner, K., Trivedi, C., Bielohuby, M., Abplanalp, W., Meyer, F., Piechowski, C. L., Pratzka, J., Stemmer, K., Holland, J., Hembree, J., Bhardwaj, N., Raver, C., Ottaway, N., Krishna, R., Sah, R., Sallee, F. R., Woods, S. C., Perez-Tilve, D., Bidlingmaier, M., Thorner, M. O., Krude, H., Smiley, D., DiMarchi, R., Hofmann, S., Pfluger, P. T., Kleinau, G., Biebermann, H., and Tschop, M. H (2013. ) The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms . Nature communications, , (4 ) ,1968

Muller, T. D., Lee, S. J., Jastroch, M., Kabra, D., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N., Collins, S., Divanovic, S., Endele, M., Finan, B., Gao, Y., Habegger, K. M., Hembree, J., Heppner, K. M., Hofmann, S., Holland, J., Kuchler, D., Kutschke, M., Krishna, R., Lehti, M., Oelkrug, R., Ottaway, N., Perez-Tilve, D., Raver, C., Walch, A. K., Schriever, S. C., Speakman, J., Tseng, Y. H., Diaz-Meco, M., Pfluger, P. T., Moscat, J., and Tschop, M. H. (2013. ) p62 links beta-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation, , (123 ) ,469-478

Lim, C. T., Kola, B., Feltrin, D., Perez-Tilve, D., Tschop, M. H., Grossman, A. B., and Korbonits, M. (2013. ) Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Molecular and cellular endocrinology, , (365 ) ,303-308

Heppner, K. M., Muller, T. D., Kirchner, H., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Hofmann, S. M. (2013. ) The role of ghrelin-octanoyl-acyl-transferase in thermoregulation . Journal of endocrinological investigation , , (36 ) ,180-184

Habegger, K. M., Stemmer, K., Cheng, C., Muller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar,A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D'Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., and Tschop, M. H. (2013. ) Fibroblast growth factor 21 mediates specific glucagon actions . Diabetes, , (62 ) ,1453-1463

Habegger, K. M., Kirchner, H., Yi, C. X., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. (2013. ) GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes., , (62 ) ,3261-3267

Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C. X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., and Tschop, M. H. (2013. ) Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut , ,

Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., and Jaeschke, A. (2013. ) MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. . American journal of physiology. Endocrinology and metabolism , , ( 305 ) ,549-556

Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. H., Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. D., and Tschop, M. H. (2013. ) Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. .Science translational medicine, , (5 ) ,209-151

Yi, C. X., Heppner, K. M., Kirchner, H., Tong, J., Bielohuby, M., Gaylinn, B. D., Muller, T. D., Bartley, E., Davis, H. W., Zhao, Y., Joseph, A., Kruthaupt, T., Ottaway, N., Kabra, D., Habegger, K. M., Benoit, S. C., Bidlingmaier, M., Thorner, M. O., Perez-Tilve, D., Tschop, M. H., and Pfluger, P. T. (2012. ) The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS ONE, , 7 ,321

Wiedmer, P., Chaudhary, N., Rath, M., Yi, C. X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schurmann, A., Joost, H. G., Tschop, M. H., and Perez-Tilve, D. (2012. ) The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiology & behavior , , (105 ) ,791-799

Stemmer, K., Perez-Tilve, D., Ananthakrishnan, G., Bort, A., Seeley, R. J., Tschop, M. H., Dietrich, D. R., and Pfluger, P. T (2012. ) High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. .Disease models & mechanisms, , (5 ) ,627-635

Muller, T. D., Sullivan, L. M., Habegger, K., Yi, C. X., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., Perez-Tilve, D., Pfluger, P. T., DeGuzman, M. J., Siladi, M. E., Kraynov, V. S., Axelrod, D. W., DiMarchi, R., Pinkstaff, J. K., and Tschop, M. H. (2012. ) Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21 .Journal of peptide science : an official publication of the European Peptide Society , , (18 ) ,383-393

Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H., and Perez-Tilve, D. (2012. ) Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling .Diabetes., , (61 ) ,2753-2762

Kirchner, H., Hofmann, S. M., Fischer-Rosinsky, A., Hembree, J., Abplanalp, W., Ottaway, N., Donelan, E., Krishna, R., Woods, S. C., Muller, T. D., Spranger, J., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Habegger, K. M. (2012. ) Caloric restriction chronically impairs metabolic programming in mice. Diabetes., , (61 ) ,2734-2742

Heppner, K. M., Chaudhary, N., Muller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B., Holst, B., Pfluger, P. T., Perez-Tilve, D., and Tschop, M. H. (2012. ) Acylation type determines ghrelin's effects on energy homeostasis in rodents. .Endocrinology , , (153 ) ,4687-4695

abegger, K. M., Matzke, D., Ottaway, N., Hembree, J., Holland, J., Raver, C., Mansfeld, J., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Lee, S. J., Diaz-Meco, M., Moscat, J., Leitges, M., Tschop, M. H., and Hofmann, S. M. (2012. ) Role of adipose and hepatic atypical protein kinase C lambda (PKClambda) in the development of obesity and glucose intolerance. Adipocyte, , (1 ) ,203-214

Finan, B., Yang, B., Ottaway, N., Stemmer, K., Muller, T. D., Yi, C. X., Habegger, K., Schriever, S. C., Garcia-Caceres, C., Kabra, D. G., Hembree, J., Holland, J., Raver, C., Seeley, R. J., Hans, W., Irmler, M., Beckers, J., de Angelis, M. H., Tiano, J. P., Mauvais-Jarvis, F., Perez-Tilve, D., Pfluger, P., Zhang, L., Gelfanov, V., DiMarchi, R. D., and Tschop, M. H. (2012. ) Targeted estrogen delivery reverses the metabolic syndrome. .Nature medicine, , (18 ) ,1847-1856

Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H (2014. ) GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.Diabetes, , 63 (2 ) ,505-13 More Information

Heppner, Kristy M; Piechowski, Carolin L; Müller, Anne; Ottaway, Nickki; Sisley, Stephanie; Smiley, David L; Habegger, Kirk M; Pfluger, Paul T; Dimarchi, Richard; Biebermann, Heike; Tschöp, Matthias H; Sandoval, Darleen A; Perez-Tilve, Diego (2014. ) Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors.Diabetes, , 63 (1 ) ,122-31 More Information

Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C; Legutko, Beata; García-Cáceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne; Thaler, Joshua P; Seeley, Randy J; Filosa, Jessica; Stern, Javier E; Perez-Tilve, Diego; Schwartz, Michael W; Tschöp, Matthias H; Yi, Chun-Xia (2014. ) Hormones and diet, but not body weight, control hypothalamic microglial activity.Glia, , 62 (1 ) ,17-25 More Information

Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H (2013. ) Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia.Gut, , More Information

Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H (2013. ) GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.Diabetes, , 62 (9 ) ,3261-7 More Information

Gadang, Vidya; Kohli, Rohit; Myronovych, Andriy; Hui, David Y; Perez-Tilve, Diego; Jaeschke, Anja (2013. ) MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.American journal of physiology. Endocrinology and metabolism, , 305 (4 ) ,E549-56 More Information

Wilson-Pérez, Hilary E; Chambers, Adam P; Ryan, Karen K; Li, Bailing; Sandoval, Darleen A; Stoffers, Doris; Drucker, Daniel J; Pérez-Tilve, Diego; Seeley, Randy J (2013. ) Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency.Diabetes, , 62 (7 ) ,2380-5 More Information

Habegger, Kirk M; Stemmer, Kerstin; Cheng, Christine; Müller, Timo D; Heppner, Kristy M; Ottaway, Nickki; Holland, Jenna; Hembree, Jazzminn L; Smiley, David; Gelfanov, Vasily; Krishna, Radha; Arafat, Ayman M; Konkar, Anish; Belli, Sara; Kapps, Martin; Woods, Stephen C; Hofmann, Susanna M; D'Alessio, David; Pfluger, Paul T; Perez-Tilve, Diego; Seeley, Randy J; Konishi, Morichika; Itoh, Nobuyujki; Kharitonenkov, Alexei; Spranger, Joachim; DiMarchi, Richard D; Tschöp, Matthias H (2013. ) Fibroblast growth factor 21 mediates specific glucagon actions.Diabetes, , 62 (5 ) ,1453-63 More Information

Heppner, K M; Müller, T D; Kirchner, H; Perez-Tilve, D; Pfluger, P T; Tschöp, M H; Hofmann, S M (2013. ) The role of ghrelin-octanoyl-acyl-transferase in thermoregulation.Journal of endocrinological investigation, , 36 (3 ) ,180-4 More Information

Lockie, Sarah H; Heppner, Kristy M; Chaudhary, Nilika; Chabenne, Joseph R; Morgan, Donald A; Veyrat-Durebex, Christelle; Ananthakrishnan, Gayathri; Rohner-Jeanrenaud, Françoise; Drucker, Daniel J; DiMarchi, Richard; Rahmouni, Kamal; Oldfield, Brian J; Tschöp, Matthias H; Perez-Tilve, Diego (2012. ) Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.Diabetes, , 61 (11 ) ,2753-62 More Information

Kirchner, Henriette; Hofmann, Susanna M; Fischer-Rosinský, Antje; Hembree, Jazzminn; Abplanalp, William; Ottaway, Nickki; Donelan, Elizabeth; Krishna, Radha; Woods, Stephen C; Müller, Timo D; Spranger, Joachim; Perez-Tilve, Diego; Pfluger, Paul T; Tschöp, Matthias H; Habegger, Kirk M (2012. ) Caloric restriction chronically impairs metabolic programming in mice.Diabetes, , 61 (11 ) ,2734-42 More Information

Habegger, Kirk M; Matzke, Daniela; Ottaway, Nickki; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Mansfeld, Johannes; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Lee, Sang Jun; Diaz-Meco, Maria; Moscat, Jorge; Leitges, Michael; Tschöp, Matthias H; Hofmann, Susanna M (2012. ) Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance.Adipocyte, , 1 (4 ) ,203-214 More Information

Heppner, Kristy M; Chaudhary, Nilika; Müller, Timo D; Kirchner, Henriette; Habegger, Kirk M; Ottaway, Nickki; Smiley, David L; Dimarchi, Richard; Hofmann, Susanna M; Woods, Stephen C; Sivertsen, Bjørn; Holst, Birgitte; Pfluger, Paul T; Perez-Tilve, Diego; Tschöp, Matthias H (2012. ) Acylation type determines ghrelin's effects on energy homeostasis in rodents.Endocrinology, , 153 (10 ) ,4687-95 More Information

Stemmer, Kerstin; Perez-Tilve, Diego; Ananthakrishnan, Gayathri; Bort, Anja; Seeley, Randy J; Tschöp, Matthias H; Dietrich, Daniel R; Pfluger, Paul T (2012. ) High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.Disease models & mechanisms, , 5 (5 ) ,627-35 More Information

Müller, Timo D; Sullivan, Lorraine M; Habegger, Kirk; Yi, Chun-Xia; Kabra, Dhiraj; Grant, Erin; Ottaway, Nickki; Krishna, Radha; Holland, Jenna; Hembree, Jazzminn; Perez-Tilve, Diego; Pfluger, Paul T; DeGuzman, Michael J; Siladi, Marc E; Kraynov, Vadim S; Axelrod, Douglas W; DiMarchi, Richard; Pinkstaff, Jason K; Tschöp, Matthias H (2012. ) Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.Journal of peptide science : an official publication of the European Peptide Society, , 18 (6 ) ,383-93 More Information

Lockie, Sarah Haas; Czyzyk, Traci A; Chaudhary, Nilika; Perez-Tilve, Diego; Woods, Stephen C; Oldfield, Brian J; Statnick, Michael A; Tschöp, Matthias H (2011. ) CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice.Endocrinology, , 152 (10 ) ,3661-7 More Information

Perez-Tilve, Diego; Habbeger, Kirk M; Tschöp, Matthias H; Hofmann, Susanna M (2011. ) Neural regulation of cholesterol metabolism.Current opinion in lipidology, , 22 (4 ) ,283-7 More Information

Habegger, Kirk M; Grant, Erin; Pfluger, Paul Thomas; Perez-Tilve, Diego; Daugherty, Alan; Bruemmer, Dennis; Tschöp, Matthias H; Hofmann, Susanna M (2011. ) Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.Frontiers in endocrinology, , 2 ,67 More Information

Smith, Eric P; An, Zhibo; Wagner, Constance; Lewis, Alfor G; Cohen, Eric B; Li, Bailing; Mahbod, Parinaz; Sandoval, Darleen; Perez-Tilve, Diego; Tamarina, Natalia; Philipson, Louis H; Stoffers, Doris A; Seeley, Randy J; D'Alessio, David A (2014. ) The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.Cell metabolism, , 19 (6 ) ,1050-7 More Information

Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H (2015. ) Calcineurin Links Mitochondrial Elongation with Energy Metabolism.Cell metabolism, , 22 (5 ) ,838-50 More Information

Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego (2015. ) Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice.Diabetologia, , 58 (9 ) ,2124-32 More Information

Ottaway, Nickki; Mahbod, Parinaz; Rivero, Belen; Norman, Lee Ann; Gertler, Arieh; D'Alessio, David A; Perez-Tilve, Diego (2015. ) Diet-induced obese mice retain endogenous leptin action.Cell metabolism, , 21 (6 ) ,877-82 More Information

Müller, T D; Nogueiras, R; Andermann, M L; Andrews, Z B; Anker, S D; Argente, J; Batterham, R L; Benoit, S C; Bowers, C Y; Broglio, F; Casanueva, F F; D'Alessio, D; Depoortere, I; Geliebter, A; Ghigo, E; Cole, P A; Cowley, M; Cummings, D E; Dagher, A; Diano, S; Dickson, S L; Diéguez, C; Granata, R; Grill, H J; Grove, K; Habegger, K M; Heppner, K; Heiman, M L; Holsen, L; Holst, B; Inui, A; Jansson, J O; Kirchner, H; Korbonits, M; Laferrère, B; LeRoux, C W; Lopez, M; Morin, S; Nakazato, M; Nass, R; Perez-Tilve, D; Pfluger, P T; Schwartz, T W; Seeley, R J; Sleeman, M; Sun, Y; Sussel, L; Tong, J; Thorner, M O; van der Lely, A J; van der Ploeg, L H T; Zigman, J M; Kojima, M; Kangawa, K; Smith, R G; Horvath, T; Tschöp, M H (2015. ) Ghrelin.Molecular metabolism, , 4 (6 ) ,437-60 More Information

Trivedi, Chitrang; Shan, Xiaoye; Tung, Yi-Chun Loraine; Kabra, Dhiraj; Holland, Jenna; Amburgy, Sarah; Heppner, Kristy; Kirchner, Henriette; Yeo, Giles S H; Perez-Tilve, Diego (2015. ) Tachykinin-1 in the central nervous system regulates adiposity in rodents.Endocrinology, , 156 (5 ) ,1714-23 More Information

Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego (2015. ) The melanocortin-4 receptor integrates circadian light cues and metabolism.Endocrinology, , 156 (5 ) ,1685-91 More Information

Heppner, Kristy M; Perez-Tilve, Diego (2015. ) GLP-1 based therapeutics: simultaneously combating T2DM and obesity.Frontiers in neuroscience, , 9 ,92 More Information

Finan, Brian; Yang, Bin; Ottaway, Nickki; Smiley, David L; Ma, Tao; Clemmensen, Christoffer; Chabenne, Joe; Zhang, Lianshan; Habegger, Kirk M; Fischer, Katrin; Campbell, Jonathan E; Sandoval, Darleen; Seeley, Randy J; Bleicher, Konrad; Uhles, Sabine; Riboulet, William; Funk, Jürgen; Hertel, Cornelia; Belli, Sara; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; Drucker, Daniel J; Gelfanov, Vasily; Pfluger, Paul T; Müller, Timo D; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H (2015. ) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.Nature medicine, , 21 (1 ) ,27-36 More Information

Perez-Tilve, Diego (2017. ) Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism.Endocrinology, , 158 (5 ) ,1085-1094 More Information

Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Mayer, John P; DiMarchi, Richard D (2016. ) Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon.ACS chemical biology, , 11 (12 ) ,3412-3420 More Information

Finan, Brian; Clemmensen, Christoffer; Zhu, Zhimeng; Stemmer, Kerstin; Gauthier, Karine; Müller, Luisa; De Angelis, Meri; Moreth, Kristin; Neff, Frauke; Perez-Tilve, Diego; Fischer, Katrin; Lutter, Dominik; Sánchez-Garrido, Miguel A; Liu, Peng; Tuckermann, Jan; Malehmir, Mohsen; Healy, Marc E; Weber, Achim; Heikenwalder, Mathias; Jastroch, Martin; Kleinert, Maximilian; Jall, Sigrid; Brandt, Sara; Flamant, Frédéric; Schramm, Karl-Werner; Biebermann, Heike; Döring, Yvonne; Weber, Christian; Habegger, Kirk M; Keuper, Michaela; Gelfanov, Vasily; Liu, Fa; Köhrle, Josef; Rozman, Jan; Fuchs, Helmut; Gailus-Durner, Valerie; Hrab? de Angelis, Martin; Hofmann, Susanna M; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard; Müller, Timo D (2016. ) Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.Cell, , 167 (3 ) ,843-857.e14 More Information

Mroz, Piotr A; Perez-Tilve, Diego; Liu, Fa; Gelfanov, Vasily; DiMarchi, Richard D; Mayer, John P (2016. ) Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.Journal of medicinal chemistry, , 59 (17 ) ,8061-7 More Information

Loyd, Christine; Magrisso, I Jack; Haas, Michael; Balusu, Sowmya; Krishna, Radha; Itoh, Nobuyuki; Sandoval, Darleen A; Perez-Tilve, Diego; Obici, Silvana; Habegger, Kirk M (2016. ) Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.Journal of applied physiology (Bethesda, Md. : 1985), , 121 (3 ) ,687-98 More Information

Sánchez-Garrido, Miguel Angel; Habegger, Kirk M; Clemmensen, Christoffer; Holleman, Cassie; Müller, Timo D; Perez-Tilve, Diego; Li, Pengyun; Agrawal, Archita S; Finan, Brian; Drucker, Daniel J; Tschöp, Matthias H; DiMarchi, Richard D; Kharitonenkov, Alexei (2016. ) Fibroblast activation protein (FAP) as a novel metabolic target.Molecular metabolism, , 5 (10 ) ,1015-24 More Information

Tschöp, Matthias H; Finan, Brian; Clemmensen, Christoffer; Gelfanov, Vasily; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D (2016. ) Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.Cell metabolism, , 24 (1 ) ,51-62 More Information

Finan, Brian; Müller, Timo D; Clemmensen, Christoffer; Perez-Tilve, Diego; DiMarchi, Richard D; Tschöp, Matthias H (2016. ) Reappraisal of GIP Pharmacology for Metabolic Diseases.Trends in molecular medicine, , 22 (5 ) ,359-76 More Information

Kabra, Dhiraj G; Pfuhlmann, Katrin; García-Cáceres, Cristina; Schriever, Sonja C; Casquero García, Veronica; Kebede, Adam Fiseha; Fuente-Martin, Esther; Trivedi, Chitrang; Heppner, Kristy; Uhlenhaut, N Henriette; Legutko, Beata; Kabra, Uma D; Gao, Yuanqing; Yi, Chun-Xia; Quarta, Carmelo; Clemmensen, Christoffer; Finan, Brian; Müller, Timo D; Meyer, Carola W; Paez-Pereda, Marcelo; Stemmer, Kerstin; Woods, Stephen C; Perez-Tilve, Diego; Schneider, Robert; Olson, Eric N; Tschöp, Matthias H; Pfluger, Paul T (2016. ) Hypothalamic leptin action is mediated by histone deacetylase 5.Nature communications, , 7 ,10782 More Information

Raab, Susanne; Wang, Haiyan; Uhles, Sabine; Cole, Nadine; Alvarez-Sanchez, Ruben; Künnecke, Basil; Ullmer, Christoph; Matile, Hugues; Bedoucha, Marc; Norcross, Roger D; Ottaway-Parker, Nickki; Perez-Tilve, Diego; Conde Knape, Karin; Tschöp, Matthias H; Hoener, Marius C; Sewing, Sabine (2016. ) Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.Molecular metabolism, , 5 (1 ) ,47-56 More Information

Mahbod, Parinaz; Smith, Eric P; Fitzgerald, Maureen E; Morano, Rachel L; Packard, Benjamin A; Ghosal, Sriparna; Scheimann, Jessie R; Perez-Tilve, Diego; Herman, James P; Tong, Jenny (2018. ) Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice.Endocrinology, , 159 (1 ) ,388-399 More Information

Ryan, Karen K; Packard, Amy E B; Larson, Karlton R; Stout, Jayna; Fourman, Sarah M; Thompson, Abigail M K; Ludwick, Kristen; Habegger, Kirk M; Stemmer, Kerstin; Itoh, Nobuyuki; Perez-Tilve, Diego; Tschöp, Matthias H; Seeley, Randy J; Ulrich-Lai, Yvonne M (2018. ) Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.Endocrinology, , 159 (1 ) ,400-413 More Information

Knerr, Patrick J; Finan, Brian; Gelfanov, Vasily; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D (2017. ) Optimization of peptide-based polyagonists for treatment of diabetes and obesity.Bioorganic & medicinal chemistry, , More Information

Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Martin; Sandoval, Darleen; Cota, Daniela; Latz, Eicke; Seeley, Randy J; Müller, Timo D; DiMarchi, Richard D; Finan, Brian; Tschöp, Matthias H (2017. ) Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.Cell metabolism, , 26 (4 ) ,620-632.e6 More Information

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang (2018. ) An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination.Cell reports, , 23 (12 ) ,3607-3620 More Information

Agrawal, Archita; Parlee, Sebastian; Perez-Tilve, Diego; Li, Pengyun; Pan, Jia; Mroz, Piotr A; Kruse Hansen, Ann Maria; Andersen, Birgitte; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D (2018. ) Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity.Molecular metabolism, , More Information

Honors and Awards

1999 -2001 Predoctoral Fellowship University of Vigo, Spain

2001 -2004 Predoctoral Fellowship Autonomic Government of Galicia, Spain

2004 -2006 Postdoctoral Fellowship Autonomic Government of Galicia and Spanish Ministry of Education and Science, Spain

Contact Information

Research - Reading Campus - Metabolic Diseases Institute
2180 E. Galbraith Rd
Cincinnati  Ohio, 45215-0503
Phone: 513-558-7700
Fax: 513-558-0466
diego.pereztilve@uc.edu