Education
Faculty of Sciences, University of Vigo Spain, 1998 (Biology)
Doctoral Degree: University of Vigo 2004 (Biological Sciences)
2004 -2009 Postdoctoral Fellowship : Obesity Research Center and Genome Research Institute, University of Cincinnati 2009 (Psychiatry)
Positions and Work Experience
2009 -To Present Research Assistant Professor, Division of Endocrinology, Diabetes & Metabolism, Unviersity of Cincinanti College of Medicine, Cincinnati, OH
Research Support
Grant: #R01 DK077975 Investigators:Hui, David; Obici, Silvana; Perez-Tilve, Diego; Stern, Javier; Tschoep, Matthias 01-15-2009 -12-31-2013 National Inst of Diabetes and Digestive and Kidney Disease Neuroendocrine Regulation of Adipocyte Metabolism Role:PI $1,747,173.00 Active Level:Federal
Grant: #Insulin Tests in Rodents Investigators:Perez-Tilve, Diego 01-01-2014 -12-31-2014 Calibrium Novel peptide-based therapies for the treatment of diabetes Role:PI $311,578.00 Active Level:Industry
Grant: #2017 ISRA Investigators:Perez-Tilve, Diego 01-01-2017 -12-31-2017 CohBar, Inc. Cohbar agreement 2017 Role:PI $376,583.00 Active Level:Industry
Grant: #2019 Industry Sponsored Agreement 08-07-2019 -08-07-2020 MBX Biosciences, Inc MBX Role:PI $275,720.00 Awarded Level:Industry
Grant: #2019 Industry Sponsored Agreement 08-07-2019 -08-07-2020 MBX Biosciences, Inc MBX Role:PI $275,720.00 Awarded Level:Industry
Grant: #2019 Sponsored Research Agreement Investigators:Perez-Tilve, Diego 01-01-2020 -12-31-2022 Novo Nordisk A/S Novel peptide-based therapies for the treatment of diabetes - 2019 agreement Role:PI $1,309,722.08 Awarded Level:Foreign Industry
Grant: #2020 Agreement_Continuation_Yr 2 Investigators:Perez-Tilve, Diego 08-08-2020 -08-08-2021 MBX Biosciences, Inc MBX Biosciences SPONSORED RESEARCH AGREEMENT Role:PI $305,171.00 Active Level:Industry
Grant: #R01GM144426 Investigators:Perez-Tilve, Diego; Sasaki, Atsuo 12-15-2022 -11-30-2026 National Institute of General Medical Sciences Mechanistic role of phosphatidylinositol 5-phosphate 4-kinase beta in GTP-dependent lysosomal acidification for stress-resilient cell growth and metabolism Role:Collaborator 372318.00 Awarded Level:Federal
01-01-2024 -12-31-2024 Bluewater Biosciences, Inc. Peptide nuclear hormone chimeric pharmacology Role:PI 643743.17 Hold Level:Industry
03-01-2024 -02-28-2025 Ghrelco, Inc. GHRELCO: PEG-Leptin Role:PI 643743.00 Hold Level:Industry
03-01-2024 -02-28-2025 Ghrelco, Inc. GHRELCO: PEG-Leptin Role:PI 643743.00 Hold Level:Industry
Grant: #IBRI Service Agr 10-01-2024 -03-31-2025 Indiana Biosciences Research Institute Development of multi receptor agonists from the treatment of metabolic diseases. Role:PI 104279.27 Hold
Grant: #IBRI Service Agr 10-01-2024 -03-31-2025 Indiana Biosciences Research Institute Development of multi receptor agonists from the treatment of metabolic diseases. Role:PI 104279.27 Hold
Grant: #IBRI Service Agr 09-01-2025 -12-31-2025 Indiana Biosciences Research Institute Development of multi receptor agonists from the treatment of metabolic diseases. Role:PI 118013.50 Hold Level:Non Profit
Grant: #IBRI Service Agr 09-01-2025 -12-31-2025 Indiana Biosciences Research Institute Development of multi receptor agonists from the treatment of metabolic diseases. Role:PI 118013.50 Hold Level:Non Profit
Publications
Peer Reviewed Publications
Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M (2011). CNS regulation of plasma cholesterol. Annals of medicineMore Information
Perez-Tilve, Diego; Heppner, Kristy; Kirchner, Henriette; Lockie, Sarah H; Woods, Stephen C; Smiley, David L; Tschöp, Matthias; Pfluger, Paul (2011). Ghrelin-induced adiposity is independent of orexigenic effects. The FASEB journal : official publication of the Federation of American Societies for Experimental BiologyMore Information
Pfluger, Paul T; Castañeda, Tamara R; Heppner, Kristy M; Strassburg, Sabine; Kruthaupt, Traci; Chaudhary, Nilika; Halem, Heather; Culler, Michael D; Datta, Rakesh; Burget, Lukas; Tschöp, M H; Nogueiras, Ruben; Perez-Tilve, Diego (2011). Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiology & behaviorMore Information
Patterson, James T; Ottaway, Nickki; Gelfanov, Vasily M; Smiley, David L; Perez-Tilve, Diego; Pfluger, Paul T; Tschöp, Matthias H; Dimarchi, Richard D (2011). A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. ACS chemical biology, 6 (2) , 135-45More Information
Müller, Timo D; Perez-Tilve, Diego; Tong, Jenny; Pfluger, Paul T; Tschöp, Matthias H (2010). Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. Journal of cachexia, sarcopenia and muscle, 1 (2) , 159-167More Information
Strassburg, Sabine; Pfluger, Paul T; Chaudhary, Nilika; Tso, Patrick; Tschöp, Matthias H; Anker, Stefan D; Nogueiras, Ruben; Perez-Tilve, Diego (2010). Action profile of the antiobesity drug candidate oleoyl-estrone in rats. Obesity (Silver Spring, Md.), 18 (12) , 2260-7More Information
Horvath, Tamas L; Sarman, Beatrix; García-Cáceres, Cristina; Enriori, Pablo J; Sotonyi, Peter; Shanabrough, Marya; Borok, Erzsebet; Argente, Jesus; Chowen, Julie A; Perez-Tilve, Diego; Pfluger, Paul T; Brönneke, Hella S; Levin, Barry E; Diano, Sabrina; Cowley, Michael A; Tschöp, Matthias H (2010). Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings of the National Academy of Sciences of the United States of America, 107 (33) , 14875-80More Information
Heppner, Kristy M; Habegger, Kirk M; Day, Jonathan; Pfluger, Paul T; Perez-Tilve, Diego; Ward, Brian; Gelfanov, Vasily; Woods, Steve C; DiMarchi, Richard; Tschöp, Matthias (2010). Glucagon regulation of energy metabolism. Physiology & behavior, 100 (5) , 545-8More Information
Lee, Sang Jun; Kim, Ji Young; Nogueiras, Ruben; Linares, Juan F; Perez-Tilve, Diego; Jung, Dae Young; Ko, Hwi Jin; Hofmann, Susanna M; Drew, Angela; Leitges, Michael; Kim, Jason K; Tschöp, Matthias H; Diaz-Meco, Maria T; Moscat, Jorge (2010). PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell metabolism, 12 (1) , 65-77More Information
Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H (2010). Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature neuroscience, 13 (7) , 877-82More Information
Gil-Lozano, Manuel; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Martís, Aurelio; Fernandez, Ana M; Catalina, Pablo A F; Gonzalez-Matias, Lucas C; Mallo, Federico (2010). GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. Endocrinology, 151 (6) , 2629-40More Information
Stefater, Margaret A; Pérez-Tilve, Diego; Chambers, Adam P; Wilson-Pérez, Hilary E; Sandoval, Darleen A; Berger, José; Toure, Mouhamadoul; Tschöp, Matthias; Woods, Stephen C; Seeley, Randy J (2010). Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology, 138 (7) , 2426-36, 2436.e1-3More Information
Pérez-Tilve, Diego; González-Matías, Lucas; Aulinger, Benedikt A; Alvarez-Crespo, Mayte; Gil-Lozano, Manuel; Alvarez, Elias; Andrade-Olivie, Amalia M; Tschöp, Matthias H; D'Alessio, David A; Mallo, Federico (2010). Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. American journal of physiology. Endocrinology and metabolism, 298 (5) , E1088-96More Information
Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H (2010). CNS leptin action modulates immune response and survival in sepsis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 (17) , 6036-47More Information
Sutton, Gregory M; Begriche, Karima; Kumar, K Ganesh; Gimble, Jeffrey M; Perez-Tilve, Diego; Nogueiras, Ruben; McMillan, Ryan P; Hulver, Matthew W; Tschöp, Matthias H; Butler, Andrew A (2010). Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 (3) , 862-72More Information
Day, Jonathan W; Ottaway, Nickki; Patterson, James T; Gelfanov, Vasily; Smiley, David; Gidda, Jas; Findeisen, Hannes; Bruemmer, Dennis; Drucker, Daniel J; Chaudhary, Nilika; Holland, Jenna; Hembree, Jazzminn; Abplanalp, William; Grant, Erin; Ruehl, Jennifer; Wilson, Hilary; Kirchner, Henriette; Lockie, Sarah Haas; Hofmann, Susanna; Woods, Stephen C; Nogueiras, Ruben; Pfluger, Paul T; Perez-Tilve, Diego; DiMarchi, Richard; Tschöp, Matthias H (2009). A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nature chemical biology, 5 (10) , 749-57More Information
Nogueiras, Ruben; Pérez-Tilve, Diego; Veyrat-Durebex, Christelle; Morgan, Donald A; Varela, Luis; Haynes, William G; Patterson, James T; Disse, Emmanuel; Pfluger, Paul T; López, Miguel; Woods, Stephen C; DiMarchi, Richard; Diéguez, Carlos; Rahmouni, Kamal; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H (2009). Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29 (18) , 5916-25More Information
Sutton, Gregory M; Perez-Tilve, Diego; Nogueiras, Ruben; Fang, Jidong; Kim, Jason K; Cone, Roger D; Gimble, Jeffrey M; Tschöp, Matthias H; Butler, Andrew A (2008). The melanocortin-3 receptor is required for entrainment to meal intake. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 (48) , 12946-55More Information
Perez-Tilve, Diego; D'Alessio, David A; Tschöp, Matthias H (2008). A sweet spot for the bariatric surgeon. Cell metabolism, 8 (3) , 177-9More Information
Strassburg, Sabine; Anker, Stefan D; Castaneda, Tamara R; Burget, Lukas; Perez-Tilve, Diego; Pfluger, Paul T; Nogueiras, Ruben; Halem, Heather; Dong, Jesse Z; Culler, Michael D; Datta, Rakesh; Tschöp, Matthias H (2008). Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. American journal of physiology. Endocrinology and metabolism, 295 (1) , E78-84More Information
Nogueiras, Ruben; López, Miguel; Lage, Ricardo; Perez-Tilve, Diego; Pfluger, Paul; Mendieta-Zerón, Hugo; Sakkou, Maria; Wiedmer, Petra; Benoit, Stephen C; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark; Vidal-Puig, Antonio; Horvath, Tamas; Treier, Mathias; Diéguez, Carlos; Tschöp, Matthias H (2008). Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology, 149 (6) , 3009-15More Information
López, Miguel; Lage, Ricardo; Saha, Asish K; Pérez-Tilve, Diego; Vázquez, María J; Varela, Luis; Sangiao-Alvarellos, Susana; Tovar, Sulay; Raghay, Kawtar; Rodríguez-Cuenca, Sergio; Deoliveira, Rosangela M; Castañeda, Tamara; Datta, Rakesh; Dong, Jesse Z; Culler, Michael; Sleeman, Mark W; Alvarez, Clara V; Gallego, Rosalía; Lelliott, Christopher J; Carling, David; Tschöp, Matthias H; Diéguez, Carlos; Vidal-Puig, Antonio (2008). Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell metabolism, 7 (5) , 389-99More Information
Pfluger, Paul T; Kirchner, Henriette; Günnel, Susanne; Schrott, Brigitte; Perez-Tilve, Diego; Fu, Sheng; Benoit, Stephen C; Horvath, Tamas; Joost, Hans-Georg; Wortley, Katherine E; Sleeman, Mark W; Tschöp, Matthias H (2008). Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. American journal of physiology. Gastrointestinal and liver physiology, 294 (3) , G610-8More Information
Tizzano, Joseph P; Stribling, D Sloan; Perez-Tilve, Diego; Strack, Alison; Frassetto, Andrea; Chen, Richard Z; Fong, Tung M; Shearman, Lauren; Krieter, Philip A; Tschöp, Matthias H; Skolnick, Phil; Basile, Anthony S (2008). The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. The Journal of pharmacology and experimental therapeutics, 324 (3) , 1111-26More Information
Hofmann, Susanna M; Perez-Tilve, Diego; Greer, Todd M; Coburn, Beth A; Grant, Erin; Basford, Joshua E; Tschöp, Matthias H; Hui, David Y (2008). Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes, 57 (1) , 5-12More Information
Hofmann, Susanna M; Zhou, Li; Perez-Tilve, Diego; Greer, Todd; Grant, Erin; Wancata, Lauren; Thomas, Andrew; Pfluger, Paul T; Basford, Joshua E; Gilham, Dean; Herz, Joachim; Tschöp, Matthias H; Hui, David Y (2007). Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. The Journal of clinical investigation, 117 (11) , 3271-82More Information
Nogueiras, Ruben; Wiedmer, Petra; Perez-Tilve, Diego; Veyrat-Durebex, Christelle; Keogh, Julia M; Sutton, Gregory M; Pfluger, Paul T; Castaneda, Tamara R; Neschen, Susanne; Hofmann, Susanna M; Howles, Philip N; Morgan, Donald A; Benoit, Stephen C; Szanto, Ildiko; Schrott, Brigitte; Schürmann, Annette; Joost, Hans-Georg; Hammond, Craig; Hui, David Y; Woods, Stephen C; Rahmouni, Kamal; Butler, Andrew A; Farooqi, I Sadaf; O'Rahilly, Stephen; Rohner-Jeanrenaud, Françoise; Tschöp, Matthias H (2007). The central melanocortin system directly controls peripheral lipid metabolism. The Journal of clinical investigation, 117 (11) , 3475-88More Information
Nomiyama, Takashi; Perez-Tilve, Diego; Ogawa, Daisuke; Gizard, Florence; Zhao, Yue; Heywood, Elizabeth B; Jones, Karrie L; Kawamori, Ryuzo; Cassis, Lisa A; Tschöp, Matthias H; Bruemmer, Dennis (2007). Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. The Journal of clinical investigation, 117 (10) , 2877-88More Information
Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Alvarez-Crespo, Mayte; Mallo, Federico (2007). Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. Endocrine, 31 (2) , 119-24
Pérez-Tilve, Diego; González-Matías, Lucas; Alvarez-Crespo, Mayte; Leiras, Roberto; Tovar, Sulay; Diéguez, Carlos; Mallo, Federico (2007). Exendin-4 potently decreases ghrelin levels in fasting rats. Diabetes, 56 (1) , 143-51More Information
Nogueiras, Rubén; Pfluger, Paul; Tovar, Sulay; Arnold, Myrtha; Mitchell, Sharon; Morris, Amanda; Perez-Tilve, Diego; Vázquez, Maria J; Wiedmer, Petra; Castañeda, Tamara R; DiMarchi, Richard; Tschöp, Matthias; Schurmann, Annette; Joost, Hans-Georg; Williams, Lynda M; Langhans, Wolfgang; Diéguez, Carlos (2007). Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology, 148 (1) , 21-6More Information
Theander-Carrillo, Claudia; Wiedmer, Petra; Cettour-Rose, Philippe; Nogueiras, Ruben; Perez-Tilve, Diego; Pfluger, Paul; Castaneda, Tamara R; Muzzin, Patrick; Schürmann, Annette; Szanto, Ildiko; Tschöp, Matthias H; Rohner-Jeanrenaud, Françoise (2006). Ghrelin action in the brain controls adipocyte metabolism. The Journal of clinical investigation, 116 (7) , 1983-93More Information
Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico (2006). Fibroblast growth factor-2 and epidermal growth factor modulate prolactin responses to TRH and dopamine in primary cultures. Endocrine, 29 (2) , 317-24More Information
Perez-Tilve, Diego; Stern, Javier E; Tschöp, Matthias (2006). The brain and the metabolic syndrome: not a wireless connection. Endocrinology, 147 (3) , 1136-9More Information
Perez-Tilve, Diego; Nogueiras, Ruben; Mallo, Federico; Benoit, Stephen C; Tschoep, Matthias (2006). Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine, 29 (1) , 61-71
Spuch, Carlos; Diz-Chaves, Yolanda; Pérez-Tilve, Diego; Mallo, Federico (2004). Heparin increases prolactin and modifies the effects of fgf-2 upon prolactin accumulation in pituitary primary cultures. Endocrine, 24 (2) , 131-6More Information
Diz Chaves, Yolanda; Spuch Calvar, Carlos; Pérez Tilve, Diégo; Mallo Ferrer, Federico (2003). GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats. Life sciences, 73 (26) , 3375-85
Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, (2014). Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. . Diabetes. (63) , 122-131
Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. (2014). GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. Diabetes. (63) , 505-13
Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. (2014). Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia (62) , 17-25
Wilson-Perez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Perez-Tilve, D., and Seeley, R. J. (2013). Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. . Diabetes. (62) , 2380-2385
Ward, B. P., Ottaway, N. L., Perez-Tilve, D., Ma, D., Gelfanov, V. M., Tschop, M. H., and Dimarchi, R. D (2013). Peptide lipidation stabilizes structure to enhance biological function. Molecular metabolism (2) , 468-479
Muller, T. D., Muller, A., Yi, C. X., Habegger, K. M., Meyer, C. W., Gaylinn, B. D., Finan, B., Heppner, K., Trivedi, C., Bielohuby, M., Abplanalp, W., Meyer, F., Piechowski, C. L., Pratzka, J., Stemmer, K., Holland, J., Hembree, J., Bhardwaj, N., Raver, C., Ottaway, N., Krishna, R., Sah, R., Sallee, F. R., Woods, S. C., Perez-Tilve, D., Bidlingmaier, M., Thorner, M. O., Krude, H., Smiley, D., DiMarchi, R., Hofmann, S., Pfluger, P. T., Kleinau, G., Biebermann, H., and Tschop, M. H (2013). The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature communications (4) , 1968
Muller, T. D., Lee, S. J., Jastroch, M., Kabra, D., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N., Collins, S., Divanovic, S., Endele, M., Finan, B., Gao, Y., Habegger, K. M., Hembree, J., Heppner, K. M., Hofmann, S., Holland, J., Kuchler, D., Kutschke, M., Krishna, R., Lehti, M., Oelkrug, R., Ottaway, N., Perez-Tilve, D., Raver, C., Walch, A. K., Schriever, S. C., Speakman, J., Tseng, Y. H., Diaz-Meco, M., Pfluger, P. T., Moscat, J., and Tschop, M. H. (2013). p62 links beta-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation (123) , 469-478
Lim, C. T., Kola, B., Feltrin, D., Perez-Tilve, D., Tschop, M. H., Grossman, A. B., and Korbonits, M. (2013). Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Molecular and cellular endocrinology (365) , 303-308
Heppner, K. M., Muller, T. D., Kirchner, H., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Hofmann, S. M. (2013). The role of ghrelin-octanoyl-acyl-transferase in thermoregulation. Journal of endocrinological investigation (36) , 180-184
Habegger, K. M., Stemmer, K., Cheng, C., Muller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar,A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D'Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., and Tschop, M. H. (2013). Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes (62) , 1453-1463
Habegger, K. M., Kirchner, H., Yi, C. X., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. (2013). GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes. (62) , 3261-3267
Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C. X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., and Tschop, M. H. (2013). Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut
Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., and Jaeschke, A. (2013). MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. . American journal of physiology. Endocrinology and metabolism ( 305) , 549-556
Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. H., Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. D., and Tschop, M. H. (2013). Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. . Science translational medicine (5) , 209-151
Yi, C. X., Heppner, K. M., Kirchner, H., Tong, J., Bielohuby, M., Gaylinn, B. D., Muller, T. D., Bartley, E., Davis, H. W., Zhao, Y., Joseph, A., Kruthaupt, T., Ottaway, N., Kabra, D., Habegger, K. M., Benoit, S. C., Bidlingmaier, M., Thorner, M. O., Perez-Tilve, D., Tschop, M. H., and Pfluger, P. T. (2012). The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS ONE, 7, 321
Wiedmer, P., Chaudhary, N., Rath, M., Yi, C. X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schurmann, A., Joost, H. G., Tschop, M. H., and Perez-Tilve, D. (2012). The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiology & behavior (105) , 791-799
Stemmer, K., Perez-Tilve, D., Ananthakrishnan, G., Bort, A., Seeley, R. J., Tschop, M. H., Dietrich, D. R., and Pfluger, P. T (2012). High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. . Disease models & mechanisms (5) , 627-635
Muller, T. D., Sullivan, L. M., Habegger, K., Yi, C. X., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., Perez-Tilve, D., Pfluger, P. T., DeGuzman, M. J., Siladi, M. E., Kraynov, V. S., Axelrod, D. W., DiMarchi, R., Pinkstaff, J. K., and Tschop, M. H. (2012). Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. Journal of peptide science : an official publication of the European Peptide Society (18) , 383-393
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abegger, K. M., Matzke, D., Ottaway, N., Hembree, J., Holland, J., Raver, C., Mansfeld, J., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Lee, S. J., Diaz-Meco, M., Moscat, J., Leitges, M., Tschop, M. H., and Hofmann, S. M. (2012). Role of adipose and hepatic atypical protein kinase C lambda (PKClambda) in the development of obesity and glucose intolerance. Adipocyte (1) , 203-214
Finan, B., Yang, B., Ottaway, N., Stemmer, K., Muller, T. D., Yi, C. X., Habegger, K., Schriever, S. C., Garcia-Caceres, C., Kabra, D. G., Hembree, J., Holland, J., Raver, C., Seeley, R. J., Hans, W., Irmler, M., Beckers, J., de Angelis, M. H., Tiano, J. P., Mauvais-Jarvis, F., Perez-Tilve, D., Pfluger, P., Zhang, L., Gelfanov, V., DiMarchi, R. D., and Tschop, M. H. (2012). Targeted estrogen delivery reverses the metabolic syndrome. . Nature medicine (18) , 1847-1856
Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; Dimarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H (2014). GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes, 63 (2) , 505-13More Information
Heppner, Kristy M; Piechowski, Carolin L; Müller, Anne; Ottaway, Nickki; Sisley, Stephanie; Smiley, David L; Habegger, Kirk M; Pfluger, Paul T; Dimarchi, Richard; Biebermann, Heike; Tschöp, Matthias H; Sandoval, Darleen A; Perez-Tilve, Diego (2014). Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes, 63 (1) , 122-31More Information
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Habegger, Kirk M; Kirchner, Henriette; Yi, Chun-Xia; Heppner, Kristy M; Sweeney, Dan; Ottaway, Nickki; Holland, Jenna; Amburgy, Sarah; Raver, Christine; Krishna, Radhakrishna; Müller, Timo D; Perez-Tilve, Diego; Pfluger, Paul T; Obici, Silvana; DiMarchi, Richard D; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H (2013). GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. Diabetes, 62 (9) , 3261-7More Information
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Heppner, K M; Müller, T D; Kirchner, H; Perez-Tilve, D; Pfluger, P T; Tschöp, M H; Hofmann, S M (2013). The role of ghrelin-octanoyl-acyl-transferase in thermoregulation. Journal of endocrinological investigation, 36 (3) , 180-4More Information
Lockie, Sarah H; Heppner, Kristy M; Chaudhary, Nilika; Chabenne, Joseph R; Morgan, Donald A; Veyrat-Durebex, Christelle; Ananthakrishnan, Gayathri; Rohner-Jeanrenaud, Françoise; Drucker, Daniel J; DiMarchi, Richard; Rahmouni, Kamal; Oldfield, Brian J; Tschöp, Matthias H; Perez-Tilve, Diego (2012). Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes, 61 (11) , 2753-62More Information
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Lockie, Sarah Haas; Czyzyk, Traci A; Chaudhary, Nilika; Perez-Tilve, Diego; Woods, Stephen C; Oldfield, Brian J; Statnick, Michael A; Tschöp, Matthias H (2011). CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology, 152 (10) , 3661-7More Information
Perez-Tilve, Diego; Habbeger, Kirk M; Tschöp, Matthias H; Hofmann, Susanna M (2011). Neural regulation of cholesterol metabolism. Current opinion in lipidology, 22 (4) , 283-7More Information
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Smith, Eric P; An, Zhibo; Wagner, Constance; Lewis, Alfor G; Cohen, Eric B; Li, Bailing; Mahbod, Parinaz; Sandoval, Darleen; Perez-Tilve, Diego; Tamarina, Natalia; Philipson, Louis H; Stoffers, Doris A; Seeley, Randy J; D'Alessio, David A (2014). The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell metabolism, 19 (6) , 1050-7More Information
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Heppner, Kristy M; Marks, Sarah; Holland, Jenna; Ottaway, Nickki; Smiley, David; Dimarchi, Richard; Perez-Tilve, Diego (2015). Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice. Diabetologia, 58 (9) , 2124-32More Information
Ottaway, Nickki; Mahbod, Parinaz; Rivero, Belen; Norman, Lee Ann; Gertler, Arieh; D'Alessio, David A; Perez-Tilve, Diego (2015). Diet-induced obese mice retain endogenous leptin action. Cell metabolism, 21 (6) , 877-82More Information
Müller, T D; Nogueiras, R; Andermann, M L; Andrews, Z B; Anker, S D; Argente, J; Batterham, R L; Benoit, S C; Bowers, C Y; Broglio, F; Casanueva, F F; D'Alessio, D; Depoortere, I; Geliebter, A; Ghigo, E; Cole, P A; Cowley, M; Cummings, D E; Dagher, A; Diano, S; Dickson, S L; Diéguez, C; Granata, R; Grill, H J; Grove, K; Habegger, K M; Heppner, K; Heiman, M L; Holsen, L; Holst, B; Inui, A; Jansson, J O; Kirchner, H; Korbonits, M; Laferrère, B; LeRoux, C W; Lopez, M; Morin, S; Nakazato, M; Nass, R; Perez-Tilve, D; Pfluger, P T; Schwartz, T W; Seeley, R J; Sleeman, M; Sun, Y; Sussel, L; Tong, J; Thorner, M O; van der Lely, A J; van der Ploeg, L H T; Zigman, J M; Kojima, M; Kangawa, K; Smith, R G; Horvath, T; Tschöp, M H (2015). Ghrelin. Molecular metabolism, 4 (6) , 437-60More Information
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Arble, Deanna M; Holland, Jenna; Ottaway, Nickki; Sorrell, Joyce; Pressler, Joshua W; Morano, Rachel; Woods, Stephen C; Seeley, Randy J; Herman, James P; Sandoval, Darleen A; Perez-Tilve, Diego (2015). The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology, 156 (5) , 1685-91More Information
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Perez-Tilve, Diego (2017). Novel Hypothalamic Mechanisms in the Pathophysiological Control of Body Weight and Metabolism. Endocrinology, 158 (5) , 1085-1094More Information
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Loyd, Christine; Magrisso, I Jack; Haas, Michael; Balusu, Sowmya; Krishna, Radha; Itoh, Nobuyuki; Sandoval, Darleen A; Perez-Tilve, Diego; Obici, Silvana; Habegger, Kirk M (2016). Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. Journal of applied physiology (Bethesda, Md. : 1985), 121 (3) , 687-98More Information
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Tschöp, Matthias H; Finan, Brian; Clemmensen, Christoffer; Gelfanov, Vasily; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D (2016). Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell metabolism, 24 (1) , 51-62More Information
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Knerr, Patrick J; Finan, Brian; Gelfanov, Vasily; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D (2017). Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorganic & medicinal chemistryMore Information
Quarta, Carmelo; Clemmensen, Christoffer; Zhu, Zhimeng; Yang, Bin; Joseph, Sini S; Lutter, Dominik; Yi, Chun-Xia; Graf, Elisabeth; García-Cáceres, Cristina; Legutko, Beata; Fischer, Katrin; Brommage, Robert; Zizzari, Philippe; Franklin, Bernardo S; Krueger, Martin; Koch, Marco; Vettorazzi, Sabine; Li, Pengyun; Hofmann, Susanna M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Lickert, Heiko; Strom, Tim M; Gailus-Durner, Valerie; Bechmann, Ingo; Perez-Tilve, Diego; Tuckermann, Jan; Hrab? de Angelis, Martin; Sandoval, Darleen; Cota, Daniela; Latz, Eicke; Seeley, Randy J; Müller, Timo D; DiMarchi, Richard D; Finan, Brian; Tschöp, Matthias H (2017). Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell metabolism, 26 (4) , 620-632.e6More Information
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Yang, Bin; Gelfanov, Vasily M; Perez-Tilve, Diego; DuBois, Barent; Rohlfs, Rebecca; Levy, Jay; Douros, Jonathan D; Finan, Brian; Mayer, John P; DiMarchi, Richard D (2021). Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. Journal of medicinal chemistry, 64 (8) , 4697-4708More Information
Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Perez-Tilve, Diego; Salinno, Ciro; Sehrer, Laura; DiMarchi, Richard D; Tschöp, Matthias H; Stemmer, Kerstin; Finan, Brian; Wolfrum, Christian; Müller, Timo D (2021). The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism, 33 (4) , 833-844.e5More Information
Zizzari, Philippe; He, Rongjun; Falk, Sarah; Bellocchio, Luigi; Allard, Camille; Clark, Samantha; Lesté-Lasserre, Thierry; Marsicano, Giovanni; Clemmensen, Christoffer; Perez-Tilve, Diego; Finan, Brian; Cota, Daniela; Quarta, Carmelo (2021). CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity. Diabetes, 70 (2) , 415-422More Information
Sorrell, Joyce; Yates, Emily; Rivir, Marita; Woods, Stephen C; Hogenesch, John B; Perez-Tilve, Diego (2020). The central melanocortin system mediates the benefits of time-restricted feeding on energy balance. Physiology & behavior, 227, 113132More Information
Pan, Jia; Parlee, Sebastian D; Brunel, Florence M; Li, Pengyun; Lu, Wei; Perez-Tilve, Diego; Liu, Fa; Finan, Brian; Kharitonenkov, Alexei; DiMarchi, Richard D (2020). Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21. ACS pharmacology & translational science, 3 (5) , 978-986More Information
Kabotso, Daniel E K; Smiley, David; Mayer, John P; Gelfanov, Vasily M; Perez-Tilve, Diego; DiMarchi, Richard D; Pohl, Nicola L B; Liu, Fa (2020). Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence. Journal of medicinal chemistry, 63 (11) , 6134-6143More Information
Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D (2020). Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates. Peptides, 125, 170225More Information
Perez-Tilve, Diego (2020). Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances. Endocrinology, 161 (2) More Information
Müller, T D; Finan, B; Bloom, S R; D'Alessio, D; Drucker, D J; Flatt, P R; Fritsche, A; Gribble, F; Grill, H J; Habener, J F; Holst, J J; Langhans, W; Meier, J J; Nauck, M A; Perez-Tilve, D; Pocai, A; Reimann, F; Sandoval, D A; Schwartz, T W; Seeley, R J; Stemmer, K; Tang-Christensen, M; Woods, S C; DiMarchi, R D; Tschöp, M H (2019). Glucagon-like peptide 1 (GLP-1). Molecular metabolism, 30, 72-130More Information
Zaykov, Alexander N; Gelfanov, Vasily M; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D (2019). Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice. Peptides, 120, 170116More Information
Brunel, Florence M; Mayer, John P; Gelfanov, Vasily M; Zaykov, Alexander N; Finan, Brian; Perez-Tilve, Diego; DiMarchi, Richard D (2019). A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. ACS chemical biology, 14 (8) , 1829-1835More Information
Holland, Jenna; Sorrell, Joyce; Yates, Emily; Smith, Kathleen; Arbabi, Shahriar; Arnold, Myrtha; Rivir, Marita; Morano, Rachel; Chen, Jenny; Zhang, Xiang; Dimarchi, Richard; Woods, Stephen C; Sanchez-Gurmaches, Joan; Wohleb, Eric; Perez-Tilve, Diego (2019). A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake. Cell reports, 27 (8) , 2399-2410.e6More Information
Perez-Tilve, Diego (2019). 'Et Tu, Leptin?'. Trends in endocrinology and metabolism: TEM, 30 (4) , 232-233More Information
Mroz, Piotr A; Finan, Brian; Gelfanov, Vasily; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D; Perez-Tilve, Diego (2019). Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism. Molecular metabolism, 20, 51-62More Information
Rivero-Gutierrez, Belen; Haller, April; Holland, Jenna; Yates, Emily; Khrisna, Radha; Habegger, Kirk; Dimarchi, Richard; D'Alessio, David; Perez-Tilve, Diego (2018). Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. Molecular metabolism, 17, 28-38More Information
Kim, Teayoun; Holleman, Cassie L; Nason, Shelly; Arble, Deanna M; Ottaway, Nickki; Chabenne, Joseph; Loyd, Christine; Kim, Jeong-A; Sandoval, Darleen; Drucker, Daniel J; DiMarchi, Richard; Perez-Tilve, Diego; Habegger, Kirk M (2018). Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes, 67 (11) , 2157-2166More Information
Kim, Teayoun; Nason, Shelly; Holleman, Cassie; Pepin, Mark; Wilson, Landon; Berryhill, Taylor F; Wende, Adam R; Steele, Chad; Young, Martin E; Barnes, Stephen; Drucker, Daniel J; Finan, Brian; DiMarchi, Richard; Perez-Tilve, Diego; Tschöp, Matthias; Habegger, Kirk M (2018). Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes, 67 (9) , 1773-1782More Information
Honors and Awards
1999 -2001 Predoctoral Fellowship University of Vigo, Spain
2001 -2004 Predoctoral Fellowship Autonomic Government of Galicia, Spain
2004 -2006 Postdoctoral Fellowship Autonomic Government of Galicia and Spanish Ministry of Education and Science, Spain
Contact Information
Research - Reading Campus - Metabolic Diseases Institute
2180 E. Galbraith Rd
Cincinnati
Ohio, 45215-0503
Phone: 513-558-7700
Fax: 513-558-0466
diego.pereztilve@uc.edu