Timothy Phoenix

Timothy Nicholas Phoenix

Asst Professor

Medical Sciences Building

3005M

Pharmacy Phoenix Lab - 0004

Professional Summary

Brain tumors are now the leading cause of cancer related deaths in children. The Phoenix lab is focused on advancing our understanding of brain tumor diversity, and developing new tools and therapies to improve patient outcome. Current projects build on our expertise in developmental neurobiology, genomics, and tumor microenvironment interactions. These include 1) Defining mechanisms of primary brain tumor metastasis; 2) Developing novel animal models of pediatric brain tumors for preclinical studies; 3) Determining vascular heterogeneity and barriers in pediatric brain tumors. 

Education

BS, Syracuse University Syracuse, NY, 2002 (Biochemistry)

PhD, Albany Medical College Albany, NY, 2010 (Developmental Neuroscience)

Research Support

Grant: #N/A. Investigators:Timothy Phoenix. 12-01-2016 -11-30-2017 UC Brain Tumor Center. Determining Mechanisms of Metastasis in Medulloblastoma Subgroups. Role:PI Active Type:Grant Level:University

Grant: #N/A. Investigators:Timothy Phoenix and Smruti Patel. 01-01-2017 -12-31-2017 UC Gardner Neuroscience Institute. Developing Novel Preclinical Models of Pediatric Brain Tumors. Role:Co-PI and Mentor Active Type:Grant Level:University

Publications

Peer Reviewed Publications

Phoenix TN, Patmore DM, Boop, S, Boulos N, Jacus MO, Patel YT, Roussel MF, Goumnerova L, Perreault S, Wadhwa E, Cho YJ, Roussel MF, Stewart CF, Gilbertson, RJ. (2016. )Medulloblastoma genotype dictates blood brain barrier phenotype .Cancer Cell, ,29 (4 ),508-22

Eden CJ, Ju B, Murugesan M, Phoenix TN, Nimmervoll B, Tong Y, Ellison DW, Finkelstein D, Wright K, Boulos N, Dapper J, Thiruvenkatam R, Lessman CA, Taylor MR, Gilbertson RJ. (2014. )Orthotopic models of pediatric brain tumors in zebrafish. Oncogene, ,34 (13 ),1736-42

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksfort J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. (2014. )C11orf95-RELA fusions drive oncogenic NF-kB signalling in ependymoma .Nature, ,506 (7489 ),451-55

Robinson G, Parker M, Kranenberg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Lei W, Zhu X, Chalhoub N, Baker SJ, Huether R, Wang J, Wu G, Rusch M, Hong X, Becksford J, Gupta P, Ma J, Easton J, Pounds S, Zhao D, Gajjar A, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Fulton LL, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. (2012. )Novel Mutations Target Distinct Subgroups of Medulloblastoma .Nature, ,488 (7409 ),43-48

Liddelow SA, Temple S, Møllgård K, Gehwolf R, Wagner A, Bauer H, Bauer HC, Phoenix TN, Dziegielewska KM, Saunders NR. (2012. )Molecular Characterization of Transport Mechanisms at the Developing Mouse Blood-CSF Interface: a Transcriptome Approach .PLoS One, ,7 (3 ),e33554

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. (2011. )An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma .Cancer Cell, ,20 (3 ),384-99

Liddelow SA, Dziegielewska KM, Møllgård K, Phoenix TN, Temple S, Vandeberg JL, Saunders NR. (2011. )SPARC/Osteonectin, an Endogenous Mechanism for Targeting Albumin to the Blood-Cerebrospinal Fluid Interface During Brain Development .European Journal of Neuroscience, ,34 (7 ),1062-73

Phoenix TN, and Temple S. (2010. )Spred1, a Negative Regulator of MAPK-ERK, is Enriched in CNS Germinal Zones, Dampens NSC Proliferation and Maintains Neuroepithelial Structure .Genes and Development, ,24 (1 ),45-56

Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos J, Lemischka I, Studer L, Temple S. (2009. )BMI-1 Regionally Maintains Neurogenic Stem Cells in the Forebrain .Genes and Development, ,23 (5 ),561-74

Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, and Temple S. (2006. )The Timing of Cortical Neurogenesis is Encoded Within Lineages of Individual Progenitor Cells .Nature Neuroscience, ,9 (6 ),743-51

Invited Publications

Phoenix TN. and Gilbertson RJ. (2012. )There’s a time and a place for N-Myc. Cancer Cell., 21 (5 ),593-95

Phoenix TN, Currle S, Robinson G, Gilbertson RJ. (2012. )Developmental Origins of Neural Tumors: Old Ideas, New Approaches. Neuropathology and Applied Neurobiology., 38 (3 ),222-27

Phoenix, TN, and Temple S. (2009. )Baby Got Brain: Fgf10 Sets Rostral Cortical Size. Neuron., 63 (1 ),1-3

Presentations

Invited Presentations

Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2015. )Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity. Pediatric Neuro-Oncology Basic and Translational Research Conference, San Diego, CA.

Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2014. )Medulloblastoma subtypes specify inter-tumoral vascular blood brain barrier heterogeneity .International Society for Pediatric Neuro-oncology, Singapore.

Poster Presentations

Timothy Phoenix, Deanna Patmore, Scott Boop, Megan Jacus, Yogesh Patel, Liliana Goumnerova, Sebastien Perreault, Elizabeth Wadhwa, Yoon-Jae Cho, Clinton Stewart, and Richard Gilbertson. (2016. )Medulloblastoma genotype dictates blood brain barrier phenotype .Sohn Conference: Pediatric Cancer in a Post-Genomic World, New York, NY. .

Timothy N. Phoenix and Sally Temple (2009. )Spred1, a negative regulator of MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation and maintains neuroepithelial structure .International Society for Stem Cell Research Meeting, Barcelona, Spain. .

Timothy N. Phoenix and Sally Temple. (2009. )Spred1, a negative regulator of MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation and maintains neuroepithelial structure .NIH Graduate Student Research Festival, Bethesda, MD. .

Positions and Work Experience

2016 - Assistant Professor., Division of Pharmaceutical Sciences., University of Cincinnati, College of Pharmacy., Cincinnati, OH

2002 -2004 Technical Research Associate., University of Rochester., Rochester, NY

Post Graduate Training and Education

2010-2016 Postdoctoral Fellow., My postdoctoral work focused on understanding how genetic alterations dictate differences in brain tumor subgroup biology and treatment response. , St. Jude Children's Research Hospital., ,Memphis, TN

Animal Protocol

16-07-06-01 , (Principal Investigator )Identifying Regulators of Brain Tumor Pathogenesis Expiration Date: 08-29-2019