David Plas

David Plas

Professor

Vontz Center

3312

COM Can Bio Plas Lab - 0521

Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati, Ohio 45267

Professional Summary

The Plas lab studies signal transduction control of cancer cell metabolism.  Dramatic alterations in cellular metabolism are frequently associated with oncogenic transformation, but cancer-driving mutations only rarely affect metabolic enzymes themselves.  More commonly, oncogenic mutations hijack cellular metabolism by altering key signaling pathways, through kinases such as S6K1.  We are testing targeted therapeutics, including kinase inhibitors, that interrupt oncogenic signal transduction to counteract cancer cell metabolism and sensitize cancer cells to undergo programmed cell death. 
 
Our lab works in 3 major areas, all facets of an overall cancer research program that targets metabolism by inhibiting mTORC1-S6K1 metabolic control signals.  1) We are identifying cancers with increased glycolysis resulting from FOXO inactivation, and testing the efficacy of interrupting mTORC1-S6K1 to compensate for loss of FOXOs.  2) We are developing novel approaches for targeting S6K1 to reduce oncogenic glycolysis and apoptosis resistance in PTEN-deficient cancers.  3) We are identifying and targeting a recently discovered mechanism that permits cancer cells to switch from glycolytic metabolism to an oxidative program in response to targeted therapeutics.  

By targeting metabolic control signals, the overall research program aims to produce novel therapeutic strategies for leukemia, solid tissue tumors, and CNS tumors.

Education

BS, University of Notre Dame 1993 (Biological Sciences)

Ph.D., Washington University 1998 (Immunology)

Postdoc, University of Pennsylvania 2004 (Cancer Biology)

Positions and Work Experience

1993 -1998 Ph.D. Thesis Project: “SHP-1 in Lymphocyte Antigen Receptor Signal Transduction,” Advisor: Matthew L. Thomas , Washington University,

1999 -2004 Postdoctoral Fellow: , “Mechanisms of Akt-dependent Cell Survival,” Advisor: Craig B. Thompson, Abramson Family Cancer Research Institute , University of Pennsylvania,

2004 -2012 Assistant Professor, Department of Cancer and Cell Biology,, University of Cincinnati,

2012 - Associate Professor, Department of Cancer Biology,, University of Cincinnati,

Research and Practice Interests

The Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast.  Current work is investigating the metabolic and apoptotic effects of targeting the protein kinase S6K1, using both genetic approaches and emerging experimental therapeutics.
 

Research Support

Grant: #R01 CA133164 Investigators:Gallo, Catherine; Plas, David; Yepiskoposyan, Hasmik 09-15-2008 -07-31-2014 National Cancer Institute Interrupting Akt-S6K1 Metabolic Control to Enhance Apoptotic Responses in CML Role:PI $1,333,802.00 Active Level:Federal

Grant: #107489 / 1 R01 AG033057-01A1 Investigators:Plas, David 09-15-2009 -08-31-2014 National Institute on Aging Homeostasis and Function of Regulatory T-Cells in Aging Role:PI $78,694.00 Active Level:Federal

Grant: #130522 \ R01AG033057 Investigators:Plas, David; Warshaw, Gregg 08-01-2012 -07-31-2017 National Institute on Aging Homeostasis and Function of Regulatory T cells in Aging Role:PI $63,158.00 Active Level:Federal

Grant: #R01CA168815 Investigators:Czyzyk-Krzeska, Maria; Plas, David 04-01-2013 -03-31-2018 National Cancer Institute Metabolic Adaptive Responses in Cancer Role:PI $427,706.00 Active Level:Federal

Grant: #134024 / R01 HL114582 Investigators:Plas, David 08-01-2014 -04-30-2018 National Heart, Lung and Blood Institute Role of TRAF6 in Myelodysplastic Syndrome Role:PI $6,391.00 Active Level:Federal

Grant: #K01 CA098743 Investigators:Plas, David 07-10-2004 -06-30-2008 National Cancer Institute Regulation of Cellular Survival, Size and Metabolism Role:PI $637,848.00 Closed Level:Federal

Grant: #RSG-08-293-01-CCG Investigators:Plas, David 07-01-2008 -06-30-2013 American Cancer Society - National Chapter Overcoming Pro-Survival Akt Through Tumor Suppressor Control of Metabolism Role:PI $720,000.00 Closed Level:Private Non-Profit

Grant: #138715 / 1R01AG053498-01A1 Investigators:Plas, David 03-01-2017 -02-28-2022 National Institute on Aging Metabolic alterations in age-associated dendritic cell dysfunction Role:PI $16,323.00 Active Level:Federal

Grant: #137962 / R01NS099162 Investigators:Plas, David 02-01-2017 -11-30-2017 National Institute of Neurological Disorders and Stroke Biguanide Sensitivity of Glioma Stem Cells Role:PI $8,012.00 Awarded Level:Federal

Grant: #UIC 17515-00_R01CA240835-01 Investigators:Plas, David 07-01-2019 -06-30-2024 National Cancer Institute Feedback loop and crosstalk in the mTORC1/2 signaling network Role:PI $22,528.00 Awarded Level:Federal

Grant: #1R01CA239657-01A1 Investigators:Kendler, Ady; Marko, Nicholas; Plas, David; Qi, Xiaoyang 12-01-2019 -11-30-2024 National Cancer Institute Co-targeting S6 and TAM kinases in PTEN-deficient glioblastoma Role:PI $423,892.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Barger JF, Plas DR (2010. )Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.Endocrine-related cancer, ,

Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR (2010. )FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.The Journal of biological chemistry, ,285 (21 ),15960-5

Khatri S, Plas DR (2009. )Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis .Cancer biology & therapy, ,8 (17 ),1659-61

Plas DR, Thomas G (2009. )Tubers and tumors: rapamycin therapy for benign and malignant tumors.Current opinion in cell biology, ,21 (2 ),230-6

Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR (2011. )Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin .Cancer Biology & Therapy, ,10 (12 ),1256

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA (2011. )A major role for Bim in regulatory T cell homeostasis .Journal of Immunology, ,186 (1 ),156

Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR (2011. )Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency .Proceedings of the National Academy of Sciences (USA), ,108 (6 ),2361

Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC (2011. )Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition .Cancer Research, ,71 (15 ),5204

Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF (2011. )Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells .Clinical and Experimental Metastasis, ,28 (8 ),887

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW (2011. )Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway .Plos One, ,6 (9 ),e25284

Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E (2011. )IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes .Cancer Research, ,71 (23 ),7291

Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K (2012. )Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes .Journal of Immunology, ,188 (1 ),146

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y (2014. )Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.International journal of cancer. Journal international du cancer, ,134 (1 ),9-20

Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge (2013. )Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis.Cell, ,152 (3 ),599-611

Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR (2013. )S6K1 determines the metabolic requirements for BCR-ABL survival.Oncogene, ,32 (4 ),453-61

Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A (2013. )IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.Frontiers in immunology, ,4 ,161

Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen (2011. )IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.Cancer research, ,71 (23 ),7291-300

Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F (2011. )Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells.Clinical & experimental metastasis, ,28 (8 ),887-97

Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C (2011. )Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.Cancer research, ,71 (15 ),5204-13

Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R (2011. )Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.Proceedings of the National Academy of Sciences of the United States of America, ,108 (6 ),2361-5

Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A (2011. )A major role for Bim in regulatory T cell homeostasis.Journal of immunology (Baltimore, Md. : 1950), ,186 (1 ),156-63

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R (2010. )Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin.Cancer biology & therapy, ,10 (12 ),1256-61

Plas, David R; Thompson, Craig B (2005. )Akt-dependent transformation: there is more to growth than just surviving.Oncogene, ,24 (50 ),7435-42

Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B (2005. )AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.Molecular cell, ,18 (3 ),283-93

Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B (2004. )Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,18 (11 ),1303-5

Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B (2004. )Akt stimulates aerobic glycolysis in cancer cells.Cancer research, ,64 (11 ),3892-9

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste (2004. )Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.Cancer research, ,64 (10 ),3500-7

Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B (2003. )Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, ,23 (20 ),7315-28

Plas, David R; Thompson, Craig B (2003. )Akt activation promotes degradation of tuberin and FOXO3a via the proteasome.The Journal of biological chemistry, ,278 (14 ),12361-6

Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M (2003. )Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo.Oncogene, ,22 (5 ),688-98

Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B (2002. )The CD28 signaling pathway regulates glucose metabolism. Immunity, ,16 (6 ),769-77

Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B (2002. )Homeostatic control of lymphocyte survival: potential origins and implications.Nature immunology, ,3 (6 ),515-21

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste (2002. )Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription.The Journal of biological chemistry, ,277 (17 ),15162-70

Plas, David R; Thompson, Craig B (2002. )Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, ,13 (2 ),75-8

Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B (2001. )Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, ,21 (17 ),5899-912

Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B (2001. )Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.The Journal of biological chemistry, ,276 (15 ),12041-8

Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L (1999. )Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), ,162 (10 ),5680-4

Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L (1999. )Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), ,162 (5 ),2717-24

Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M (1999. )Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), ,162 (3 ),1318-23

Plas, D R; Thomas, M L (1998. )Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), ,76 (8 ),589-95

Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D (1996. )Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.Nature, ,382 (6590 ),462-6

Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L (1996. )Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), ,272 (5265 ),1173-6

Moe, A J; Plas, D R; Powell, K A; Smith, C H Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, ,15 (2 ),137-46

Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F (2014. )TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.Cancer cell, ,26 (5 ),738-53

Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh (2015. )ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.Molecular cell, ,59 (3 ),382-98

Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar (2015. )Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.Nature communications, ,6 ,8428

Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun (2018. )R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.Cell, ,172 (1-2 ),90-105.e23

Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper (2012. )Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950), ,188 (1 ),146-54

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E (2017. )mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.Molecular cancer therapeutics, ,16 (11 ),2432-2441

Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben (2016. )S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.The Journal of clinical investigation, ,126 (7 ),2621-5

Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K (2017. )ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.Signal transduction and targeted therapy, ,2 ,

Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R (2012. )Not all autophagy is equal.Autophagy, ,8 (7 ),1155-6

Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper (2019. )Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.Science immunology, ,4 (38 ),

Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F (2012. )VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.Cancer cell, ,21 (4 ),532-46

Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario (2020. )Predicting mechanism of action of cellular perturbations with pathway activity signatures.Bioinformatics (Oxford, England), ,

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. )Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells.Molecular cancer research : MCR, ,

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. )Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, ,1 (11 ),1127-1140

Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John (2017. )Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.Molecular cell, ,

Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R (2017. )Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Cell reports, ,18 (9 ),2088-2095

Honors and Awards

2008 -2012 Research Scholar, American Cancer Society

2013 Richard Akeson Excellence in Graduate Teaching Award, University of Cincinnati.

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-7245
david.plas [at] uc.edu