David Plas

David Plas , PhD

Professor

Anna and Harold W. Huffman Endowed Chair in Glioblastoma Experimental Therapeutics

Vontz Center for Molecular Studies
3125 Eden Avenue
ML 0521
Cincinnati, Ohio 45267
Phone 513-558-7245
Email david.plas [at] uc.edu

Professional Summary

The Plas lab studies signal transduction control of cancer cell metabolism.  Dramatic alterations in cellular metabolism are frequently associated with oncogenic transformation, but cancer-driving mutations only rarely affect metabolic enzymes themselves.  More commonly, oncogenic mutations hijack cellular metabolism by altering key signaling pathways, through kinases such as S6K1.  We are testing targeted therapeutics, including kinase inhibitors, that interrupt oncogenic signal transduction to counteract cancer cell metabolism and sensitize cancer cells to undergo programmed cell death. 
 
Our lab works in 3 major areas, all facets of an overall cancer research program that targets metabolism by inhibiting mTORC1-S6K1 metabolic control signals.  1) We are identifying cancers with increased glycolysis resulting from FOXO inactivation, and testing the efficacy of interrupting mTORC1-S6K1 to compensate for loss of FOXOs.  2) We are developing novel approaches for targeting S6K1 to reduce oncogenic glycolysis and apoptosis resistance in PTEN-deficient cancers.  3) We are identifying and targeting a recently discovered mechanism that permits cancer cells to switch from glycolytic metabolism to an oxidative program in response to targeted therapeutics.  

By targeting metabolic control signals, the overall research program aims to produce novel therapeutic strategies for leukemia, solid tissue tumors, and CNS tumors.

Education

Bachelor's Degree: University of Notre Dame 1993 (Biological Sciences)

Ph.D.: Washington University 1998 (Immunology)

Postdoc: University of Pennsylvania 2004 (Cancer Biology)

Research and Practice Interests

The Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast.  Current work is investigating the metabolic and apoptotic effects of targeting the protein kinase S6K1, using both genetic approaches and emerging experimental therapeutics.
 

Positions and Work Experience

1993 -1998 Ph.D. Thesis Project: “SHP-1 in Lymphocyte Antigen Receptor Signal Transduction,” Advisor: Matthew L. Thomas , Washington University,

1999 -2004 Postdoctoral Fellow: , “Mechanisms of Akt-dependent Cell Survival,” Advisor: Craig B. Thompson, Abramson Family Cancer Research Institute , University of Pennsylvania,

2004 -2012 Assistant Professor, Department of Cancer and Cell Biology,, University of Cincinnati,

2012 - Associate Professor, Department of Cancer Biology,, University of Cincinnati,

Research Support

Grant: #R01 CA133164 Investigators:Gallo, Catherine; Plas, David; Yepiskoposyan, Hasmik 09-15-2008 -07-31-2014 National Cancer Institute Interrupting Akt-S6K1 Metabolic Control to Enhance Apoptotic Responses in CML Role:PI $1,333,802.00 Active Level:Federal

Grant: #107489 / 1 R01 AG033057-01A1 Investigators:Plas, David 09-15-2009 -08-31-2014 National Institute on Aging Homeostasis and Function of Regulatory T-Cells in Aging Role:PI $78,694.00 Active Level:Federal

Grant: #130522 \ R01AG033057 Investigators:Plas, David; Warshaw, Gregg 08-01-2012 -07-31-2017 National Institute on Aging Homeostasis and Function of Regulatory T cells in Aging Role:PI $63,158.00 Active Level:Federal

Grant: #R01CA168815 Investigators:Czyzyk-Krzeska, Maria; Plas, David 04-01-2013 -03-31-2018 National Cancer Institute Metabolic Adaptive Responses in Cancer Role:PI $427,706.00 Active Level:Federal

Grant: #134024 / R01 HL114582 Investigators:Plas, David 08-01-2014 -04-30-2018 National Heart, Lung and Blood Institute Role of TRAF6 in Myelodysplastic Syndrome Role:PI $6,391.00 Active Level:Federal

Grant: #K01 CA098743 Investigators:Plas, David 07-10-2004 -06-30-2008 National Cancer Institute Regulation of Cellular Survival, Size and Metabolism Role:PI $637,848.00 Closed Level:Federal

Grant: #RSG-08-293-01-CCG Investigators:Plas, David 07-01-2008 -06-30-2013 American Cancer Society - National Chapter Overcoming Pro-Survival Akt Through Tumor Suppressor Control of Metabolism Role:PI $720,000.00 Closed Level:Private Non-Profit

Grant: #138715 / 1R01AG053498-01A1 Investigators:Plas, David 03-01-2017 -02-28-2022 National Institute on Aging Metabolic alterations in age-associated dendritic cell dysfunction Role:PI $16,323.00 Active Level:Federal

Grant: #137962 / R01NS099162 Investigators:Plas, David 02-01-2017 -11-30-2017 National Institute of Neurological Disorders and Stroke Biguanide Sensitivity of Glioma Stem Cells Role:PI $8,012.00 Awarded Level:Federal

Grant: #UIC 17515-00_R01CA240835-01 Investigators:Plas, David 07-01-2019 -06-30-2024 National Cancer Institute Feedback loop and crosstalk in the mTORC1/2 signaling network Role:PI $22,528.00 Awarded Level:Federal

Grant: #1R01CA239657-01A1 Investigators:Kendler, Ady; Marko, Nicholas; Plas, David; Qi, Xiaoyang 12-01-2019 -11-30-2024 National Cancer Institute Co-targeting S6 and TAM kinases in PTEN-deficient glioblastoma Role:PI $423,892.00 Awarded Level:Federal

Grant: #VA IPA David Plas 10-01-2021 -06-30-2022 Department of Veterans Affairs Tumor Suppressing Pathways in Kidney Cancer - IPA agreement for David Plas Role:PI 15319.80 Hold Level:Federal

Grant: #VA IPA David Plas 10-01-2021 -06-30-2022 Department of Veterans Affairs Tumor Suppressing Pathways in Kidney Cancer - IPA agreement for David Plas Role:PI 15319.80 Hold Level:Federal

Publications

Peer Reviewed Publications

Barger JF, Plas DR (2010. ) Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis.Endocrine-related cancer, , More Information

Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR (2010. ) FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.The Journal of biological chemistry, , 285 (21 ) ,15960-5 More Information

Khatri S, Plas DR (2009. ) Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis .Cancer biology & therapy, , 8 (17 ) ,1659-61

Plas DR, Thomas G (2009. ) Tubers and tumors: rapamycin therapy for benign and malignant tumors.Current opinion in cell biology, , 21 (2 ) ,230-6 More Information

Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR (2011. ) Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin .Cancer Biology & Therapy, , 10 (12 ) ,1256

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA (2011. ) A major role for Bim in regulatory T cell homeostasis .Journal of Immunology, , 186 (1 ) ,156

Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR (2011. ) Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency .Proceedings of the National Academy of Sciences (USA), , 108 (6 ) ,2361

Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC (2011. ) Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition .Cancer Research, , 71 (15 ) ,5204

Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF (2011. ) Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells .Clinical and Experimental Metastasis, , 28 (8 ) ,887

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW (2011. ) Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway .Plos One, , 6 (9 ) ,e25284

Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E (2011. ) IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes .Cancer Research, , 71 (23 ) ,7291

Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K (2012. ) Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes .Journal of Immunology, , 188 (1 ) ,146

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y (2014. ) Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.International journal of cancer. Journal international du cancer, , 134 (1 ) ,9-20 More Information

Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge (2013. ) Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis.Cell, , 152 (3 ) ,599-611 More Information

Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR (2013. ) S6K1 determines the metabolic requirements for BCR-ABL survival.Oncogene, , 32 (4 ) ,453-61 More Information

Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A (2013. ) IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.Frontiers in immunology, , 4 ,161 More Information

Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen (2011. ) IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1.Cancer research, , 71 (23 ) ,7291-300 More Information

Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F (2011. ) Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells.Clinical & experimental metastasis, , 28 (8 ) ,887-97 More Information

Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C (2011. ) Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.Cancer research, , 71 (15 ) ,5204-13 More Information

Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R (2011. ) Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.Proceedings of the National Academy of Sciences of the United States of America, , 108 (6 ) ,2361-5 More Information

Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A (2011. ) A major role for Bim in regulatory T cell homeostasis.Journal of immunology (Baltimore, Md. : 1950), , 186 (1 ) ,156-63 More Information

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R (2010. ) Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin.Cancer biology & therapy, , 10 (12 ) ,1256-61 More Information

Plas, David R; Thompson, Craig B (2005. ) Akt-dependent transformation: there is more to growth than just surviving.Oncogene, , 24 (50 ) ,7435-42 More Information

Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B (2005. ) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.Molecular cell, , 18 (3 ) ,283-93 More Information

Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B (2004. ) Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 18 (11 ) ,1303-5 More Information

Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B (2004. ) Akt stimulates aerobic glycolysis in cancer cells.Cancer research, , 64 (11 ) ,3892-9 More Information

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste (2004. ) Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.Cancer research, , 64 (10 ) ,3500-7 More Information

Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B (2003. ) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, , 23 (20 ) ,7315-28

Plas, David R; Thompson, Craig B (2003. ) Akt activation promotes degradation of tuberin and FOXO3a via the proteasome.The Journal of biological chemistry, , 278 (14 ) ,12361-6 More Information

Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M (2003. ) Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo.Oncogene, , 22 (5 ) ,688-98 More Information

Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B (2002. ) The CD28 signaling pathway regulates glucose metabolism. Immunity, , 16 (6 ) ,769-77

Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B (2002. ) Homeostatic control of lymphocyte survival: potential origins and implications.Nature immunology, , 3 (6 ) ,515-21 More Information

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste (2002. ) Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription.The Journal of biological chemistry, , 277 (17 ) ,15162-70 More Information

Plas, David R; Thompson, Craig B (2002. ) Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, , 13 (2 ) ,75-8

Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B (2001. ) Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, , 21 (17 ) ,5899-912

Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B (2001. ) Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.The Journal of biological chemistry, , 276 (15 ) ,12041-8 More Information

Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L (1999. ) Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), , 162 (10 ) ,5680-4

Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L (1999. ) Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), , 162 (5 ) ,2717-24

Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M (1999. ) Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), , 162 (3 ) ,1318-23

Plas, D R; Thomas, M L (1998. ) Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), , 76 (8 ) ,589-95

Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D (1996. ) Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.Nature, , 382 (6590 ) ,462-6 More Information

Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L (1996. ) Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), , 272 (5265 ) ,1173-6

Moe, A J; Plas, D R; Powell, K A; Smith, C H Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, , 15 (2 ) ,137-46

Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F (2014. ) TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.Cancer cell, , 26 (5 ) ,738-53 More Information

Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh (2015. ) ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.Molecular cell, , 59 (3 ) ,382-98 More Information

Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar (2015. ) Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.Nature communications, , 6 ,8428 More Information

Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun (2018. ) R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.Cell, , 172 (1-2 ) ,90-105.e23 More Information

Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper (2012. ) Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950), , 188 (1 ) ,146-54 More Information

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E (2017. ) mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.Molecular cancer therapeutics, , 16 (11 ) ,2432-2441 More Information

Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben (2016. ) S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.The Journal of clinical investigation, , 126 (7 ) ,2621-5 More Information

Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K (2017. ) ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.Signal transduction and targeted therapy, , 2 , More Information

Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R (2012. ) Not all autophagy is equal.Autophagy, , 8 (7 ) ,1155-6 More Information

Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper (2019. ) Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.Science immunology, , 4 (38 ) , More Information

Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F (2012. ) VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.Cancer cell, , 21 (4 ) ,532-46 More Information

Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario (2020. ) Predicting mechanism of action of cellular perturbations with pathway activity signatures.Bioinformatics (Oxford, England), , More Information

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J (2017. ) Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells.Molecular cancer research : MCR, , More Information

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, , 1 (11 ) ,1127-1140 More Information

Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John (2017. ) Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.Molecular cell, , More Information

Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin (2021. ) Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.British journal of cancer, , More Information

Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R (2017. ) Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.Cell reports, , 18 (9 ) ,2088-2095 More Information

Czyzyk-Krzeska, Maria F; Landero Figueroa, Julio A; Gulati, Shuchi; Cunningham, John T; Meller, Jarek; ShamsaeI, Behrouz; Vemuri, Bhargav; Plas, David R (2021. ) Molecular and Metabolic Subtypes in Sporadic and Inherited Clear Cell Renal Cell Carcinoma.Genes, , 12 (3 ) , More Information

Qing, Ying; Dong, Lei; Gao, Lei; Li, Chenying; Li, Yangchan; Han, Li; Prince, Emily; Tan, Brandon; Deng, Xiaolan; Wetzel, Collin; Shen, Chao; Gao, Min; Chen, Zhenhua; Li, Wei; Zhang, Bin; Braas, Daniel; Ten Hoeve, Johanna; Sanchez, Gerardo Javier; Chen, Huiying; Chan, Lai N; Chen, Chun-Wei; Ann, David; Jiang, Lei; Müschen, Markus; Marcucci, Guido; Plas, David R; Li, Zejuan; Su, Rui; Chen, Jianjun (2021. ) R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.Molecular cell, , 81 (5 ) ,922-939.e9 More Information

Czyzyk-Krzeska, Maria F; Meller, Jarek; Landero Figueroa, Julio A; Plas, David R; Cunningham, John T (2021. ) Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking.Molecular & cellular oncology, , 8 (2 ) ,1859917 More Information

Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma (2021. ) Reuse of Molecules for Glioblastoma Therapy.Pharmaceuticals (Basel, Switzerland), , 14 (2 ) , More Information

Reigle, James; Secic, Dina; Biesiada, Jacek; Wetzel, Collin; Shamsaei, Behrouz; Chu, Johnson; Zang, Yuanwei; Zhang, Xiang; Talbot, Nicholas J; Bischoff, Megan E; Zhang, Yongzhen; Thakar, Charuhas V; Gaitonde, Krishnanath; Sidana, Abhinav; Bui, Hai; Cunningham, John T; Zhang, Qing; Schmidt, Laura S; Linehan, W Marston; Medvedovic, Mario; Plas, David R; Figueroa, Julio A Landero; Meller, Jarek; Czyzyk-Krzeska, Maria F (2021. ) Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.The Journal of clinical investigation, , 131 (1 ) , More Information

Bischoff, Megan E; Zang, Yuanwei; Chu, Johnson; Price, Adam D; Ehmer, Birgit; Talbot, Nicholas J; Newbold, Michael J; Paul, Anurag; Guan, Jun-Lin; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F (2021. ) Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.The Journal of cell biology, , 220 (7 ) , More Information

Honors and Awards

2008 -2012 Research Scholar, American Cancer Society

2013 Richard Akeson Excellence in Graduate Teaching Award, University of Cincinnati.

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-7245
david.plas [at] uc.edu