Margaret Powers-Fletcher

Margaret Mary VanDeMark Powers-Fletcher , PhD

Research Assistant Professor

UC Health University Hospital
234 Goodman St
Cincinnati, Ohio 45219-0533
Phone (513) 584-6476
Fax (513) 584-3892
Email powersmg@ucmail.uc.edu

Education

PhD: University of Cincinnati Medical Center 2013 (Pathobiology and Molecular Medicine)

Fellowship: University of Utah 2016 (Medical and Public Health Laboratory Microbiology)

Research Support

Grant: #12PRE12050300 Investigators:Powers, Margaret 07-01-2012 -06-30-2014 American Heart Association - Great Rivers Affiliate IreA kinase Activity and Virulence of Aspergillus Fumigatus Role:PI $25,000.00 Active Level:Private Non-Profit

Grant: #FHI360-CoVPN 3001/ UM1AI068619 Investigators:Fichtenbaum, Carl; Powers-Fletcher, Margaret 07-01-2020 -06-30-2022 National Institute of Allergy and Infectious Diseases CoVPN 3001: Phase 3, SARS-CoV-2 Vaccine (Moderna TX, Inc.) Role:Collaborator $3,269,500.00 Awarded Level:Federal

Grant: #Unknown Investigators:Fichtenbaum, Carl; Powers-Fletcher, Margaret 07-01-2020 -11-30-2020 National Institute of Allergy and Infectious Diseases COVID-19 Prevention Network (CoVPN) Role:Collaborator $380,075.01 Active Level:Federal

Grant: #PO20002913 CoVPN 5002: Prevalence / UM1AI068619 Investigators:Powers-Fletcher, Margaret 08-01-2020 -07-31-2021 National Institute of Allergy and Infectious Diseases CoVPN 5002: SARS-CoV-2 Prevalence Study Role:PI $1,400,360.00 Awarded Level:Federal

Grant: #WBSE: A034559, SPS:266338 / U24TR001608 Investigators:Brown, Douglas; Powers, Margaret 04-17-2021 -06-30-2023 Duke University ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Role:PI 512000.00 Hold Level:Higher Education

Investigators:Powers, Margaret 11-01-2021 -03-31-2022 Molecular Research Center, Inc. Validation of Novel Processing Method to Improve COVID-19 Molecular Test Performance Role:PI 0.00 Hold Level:Industry

Publications

Peer Reviewed Publications

Powers-Fletcher, Margaret V; Hanson, Kimberly E (2016. ) Molecular Diagnostic Testing for Aspergillus.Journal of clinical microbiology, , 54 (11 ) ,2655-2660 More Information

Powers-Fletcher, Margaret V; Kendall, Brian A; Griffin, Allen T; Hanson, Kimberly E (2016. ) Filamentous Fungi.Microbiology spectrum, , 4 (3 ) , More Information

Powers-Fletcher, Margaret V; Hanson, Kimberly E (2016. ) Nonculture Diagnostics in Fungal Disease.Infectious disease clinics of North America, , 30 (1 ) ,37-49 More Information

Walker, Brandon; Powers-Fletcher, Margaret V; Schmidt, Robert L; Hanson, Kimberly E (2016. ) Cost-Effectiveness Analysis of Multiplex PCR with Magnetic Resonance Detection versus Empiric or Blood Culture-Directed Therapy for Management of Suspected Candidemia.Journal of clinical microbiology, , 54 (3 ) ,718-26 More Information

Powers-Fletcher, Margaret V; Feng, Xizhi; Krishnan, Karthik; Askew, David S (2013. ) Deletion of the sec4 homolog srgA from Aspergillus fumigatus is associated with an impaired stress response, attenuated virulence and phenotypic heterogeneity.PloS one, , 8 (6 ) ,e66741 More Information

Krishnan, Karthik; Feng, Xizhi; Powers-Fletcher, Margaret V; Bick, Gregory; Richie, Daryl L; Woollett, Laura A; Askew, David S (2013. ) Effects of a defective endoplasmic reticulum-associated degradation pathway on the stress response, virulence, and antifungal drug susceptibility of the mold pathogen Aspergillus fumigatus.Eukaryotic cell, , 12 (4 ) ,512-9 More Information

Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V; Zhang, Minlu; Fuller, Kevin K; Nierman, William C; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L; Cramer, Robert A; Rhodes, Judith C; Askew, David S (2011. ) HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.PLoS pathogens, , 7 (10 ) ,e1002330 More Information

Powers-Fletcher, Margaret V; Jambunathan, Kalyani; Brewer, Jordan L; Krishnan, Karthik; Feng, Xizhi; Galande, Amit K; Askew, David S (2011. ) Impact of the lectin chaperone calnexin on the stress response, virulence and proteolytic secretome of the fungal pathogen Aspergillus fumigatus.PloS one, , 6 (12 ) ,e28865 More Information

Richie, Daryl L; Feng, Xizhi; Hartl, Lukas; Aimanianda, Vishukumar; Krishnan, Karthik; Powers-Fletcher, Margaret V; Watson, Douglas S; Galande, Amit K; White, Stephanie M; Willett, Taryn; Latgé, Jean-Paul; Rhodes, Judith C; Askew, David S The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR). Virulence, , 2 (1 ) ,12-21

Powers-Fletcher M and Barker A (2016. ) Matrix Assisted Laser Desorption Ionization Time of Flight (MALDITOF) for Microorganism Identification .Clin Micro Pro Handbook, , Fourth Edition (ASM Press ) ,

Powers-Fletcher MV, Couturier MR (2015. ) Non-Helicobacter pylori Helicobacter species associated with human disease: a primer for the clinical microbiology laboratory .Clinical Microbiology Newsletter, , 37 (12 ) ,

Powers-Fletcher M (2011. ) A Review of the Biology and the Laboratory Diagnosis of Treponema pallidum Infections .Journal of Continuing Education Topics & Issues, , 13 (3 ) ,80-93

Contact Information

Academic - UC Health University Hospital
234 Goodman St
Cincinnati  Ohio, 45219-0533
Phone: (513) 584-6476
Fax: (513) 584-3892
powersmg@ucmail.uc.edu