Charles Prestigiacomo

Charles Joseph Prestigiacomo

Professor of Clinical

Director of Cerebrovascular and Endovascular Surgery

University of Cincinnati
231 Albert Sabin Way
Cincinnati, Ohio 45267-0517
Phone 513-558-4438
Fax 513-558-7702


Bachelor's Degree: Georgetown College Washington, DC, 1989 (Biology)

Medical Degree: Columbia University College of Physicians and Surgeons New York, NY, 1993

Internship: Columbia - Presbyterian Medical Center New York, NY, 1994 (General Surgery)

Residency: Columbia - Presbyterian Medical Center New York, NY, 1995 (Neurological Surgery)

Research Fellowship: Columbia - Presbyterian Medical Center New York, NY, 1997 (Neurological Surgery)

Chief Resident: Columbia - Presbyterian Medical Center New York, NY, 1997 (Neurological Surgery)

Fellowship: Columbia - Presbyterian Medical Center New York, NY, 1998 (Interventional Radiology)

Fellowship: Beth Israel Medical Center Newark, NJ, 2002 (Endovascular Surgical Neuroradiology)


American Board of Neurological Surgery (Certification Date: 11-10-2006 ) - (Recertification Date: to 01-01-2017 )

Clinical Interests




Acute Head Bleeds

Acute Stroke


Arachnoid Cysts

Arnold-Chiari Malformation

Atherosclerotic Disease

Brain Abscess

Brain Aneurysm (Cerebral aneurysm)

Brain Arteriovenous malformation (AVM)

Brain Concussion

Brain Hemorrhage

Brain Injuries

Carotid Artery Disease

Carotid Artery Injury

Carotid Artery Stenosis

Carotid Artery, Internal, Dissection

Cavernous Hemangioma

Cavernous Malformations

Central Nervous System Vascular Malformations

Cerebral Contusion

Cerebral Hemorrhage

Cerebral venous thrombosis

Cerebrovascular Disease

Cerebrovascular Disorders

Cerebrovascular Trauma

Cervical Rib Syndrome

Chiari Malformation

Chronic Brain Injury

Comprehensive Stroke


Cranial Nerve Disease

Cranial Nerve Injuries

Cushing syndrome (Hypercortisolism)

Diffuse Axonal Injury

Facial Nerve Disease

Facial nerve injury

Facial nerve neuromas

Facial Pain

Head Injury

Head Trauma

Hemorrhagic Stroke


Intra-arterial thrombolysis

Intracerebral Hemorrhage (ICH)

Intracranial Aneurysm

Intracranial Arteriovenous Malformations

Intracranial Artery Stenosis

Intracranial Embolism and Thrombosis

Intracranial Hematoma

Intracranial Hemorrhages

Intracranial Venous Malformations

Intraventricular Hemorrhage

Mild Traumatic Brain Injury

Moyamoya Disease

Normal Pressure Hydrocephalus

Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)

Reversible Cerebral Vasoconstriction Syndrome

Ruptured Aneurysm

Severe Brain Injury

Severe Traumatic Brain Injury

Spinal Arteriovenous Malformation (AVM)

Spinal Dural Arteriovenous Fistula

Spinal Vascular Disease

Subarachnoid Hemorrhage

Subdural Hematoma

Temporal Arteritis (Giant cell arteritis)

Transient Ischemic Attack (TIA)

Transverse sinus stenosis

Traumatic Brain Injury (TBI)

Trigeminal Nerve Injuries

Trigeminal Neuralgia (Tic douloureux)


Venous Sinus Occlusion

Venous Sinus Stenosis

Vertebral Artery Dissection


Neurological Surgery

Neurovascular Emergencies

Research and Practice Interests

My research interests focus on several clinical and basic research topics.  Clinically, my interests include outcomes analysis and decision analysis for patients with the various forms of cerebrovascular and spinal vascular disease along with the treatment paradigms.  This interest also carries over to critical care and trauma management of patients since some vascular pathology is seen in these populations of patients as well.
From a more basic science perspective, I have an interesst in the biophysics and mathematics of aneurysm formation.  I have had some experience in AVM hemodynamic studies as well.

Finally, I have an interest in education research, quality metrics and improvement and the history of medicine (specifically anatomy and neurosciences/neurosurgery).

Research Support

Grant: #VUMC78063 Investigators:Prestigiacomo, Charles 01-01-2020 -06-30-2024 Vanderbilt University Medical Center BEST-II Role:PI $55,440.00 Awarded Level:Private Non-Profit

Investigators:Prestigiacomo, Charles 07-01-2022 -06-30-2025 Depuy Synthes Products, Inc. Middle Meningeal Artery Embolization for the Treatment of SuBduRal HemAtomas with TRUFILL n-BCA Role:PI 419998.00 Hold Level:Industry

Grant: #2022 BAF Research Grant Investigators:Jandarov, Roman; Johnson, Mark; Prestigiacomo, Charles; Ralescu, Anca 10-01-2022 -09-30-2023 Brain Aneurysm Foundation Morphological Analysis Through the Use of Fractal Dimension as a Predictor of Cerebral Aneurysm Behavior Role:Collaborator 30000.00 Awarded Level:Non Profit

Grant: #CL11012 (SOFAST) Investigators:Prestigiacomo, Charles -03-06-2028 MicroVention, Inc. Master Agreement with MicroVention Role:PI 0.00 Hold Level:Industry

Investigators:Prestigiacomo, Charles 10-01-2022 -09-30-2025 MicroVention, Inc. SOFAST SOFia Aspiration System as first line Technique Role:PI 0.00 Hold Level:Industry

Grant: #GTX-104-003 Investigators:Prestigiacomo, Charles 11-30-2023 -11-30-2026 Acasti Pharma, Inc. Safety and Tolerability of GTX-104 (Nimodipine Injection for IV Infusion) Compared with Oral Nimodipine in Patients Hospitalized for Aneurysmal Subarachnoid Hemorrhage (aSAH): a Prospective, Randomize Role:PI 935630.14 Hold Level:Industry

Contact Information

Academic - University of Cincinnati
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0517
Phone: 513-558-4438
Fax: 513-558-7702