CEAS - Chemical & Env Eng - 0012
Our research is primarily curiosity driven, where we take an engineering and physics based approach to explore biophysical processes occurring at the micro-scale. We then harness these principles towards applications pertaining to global health, bioengineering, and educational outreach. An overview of projects are described below:
Physics of Micro-scale Flows
Fluid flow arising due to thermal gradients (thermal instability driven convective flows) is quite ubiquitous in nature (oceanic currents, cloud formation, etc.) but they can exhibit unique characteristics at the micro-scale, capable of greatly accelerating biomolecular transport and reactions. We use computational tools (Computational Fluid Dynamics) and novel experimental setups (automated microfluidic systems) to study these flow states and evaluate the conditions under which they can be harnessed to actuate biomolecular transport and assembly, accelerate DNA replication and separate cells (based on their shape and size).
Point-of-Care Detection for Global Health
The recent disease outbreaks have exposed some key limitations facing current infectious disease management strategies, particularly when applied in remote underdeveloped areas. Existing approaches are highly resource intensive, relying on dispatching specially trained personnel to isolated locations where biological samples are collected and returned to dedicated laboratories for analysis. A need therefore exists for inexpensive and robust tools that can be broadly deployed to accelerate diagnosis, enable pinpoint delivery of therapeutics, and provide real-time data to better inform decision making. We engineer simple and portable diagnostic tools (such as smartphone based DNA analyzer and lab on a drone) that can be deployed and operated outside the laboratory to address global challenges of healthcare, environmental sampling, agriculture and science outreach. Projects under this area are quite multidisciplinary and collaborative in nature.
Microfluidics enables large-scale automation in chemical and biological sciences, suggesting the possibility of numerous experiments performed rapidly and in parallel while consuming little reagents. This has led to the emergence of the so-called lab on chip systems, making significant strides in diverse areas ranging from grand challenges such as water purification to fundamental research such as genetic analysis. Despite significant advances, few roadblocks has hindered microfluidic systems from replacing convectional bench-top analytical tools and widely penetrate the point of care in low resource settings where they are needed most. We aim to create the next generation of microfluidic devices using rapid fabrication techniques (3D printing, micro-milling and laser cutting) that would drastically simplify the prototyping and assembly processes of microfluidics systems.
We have a few positions open for passionate postdoctoral, graduate (prospective PhD/Master’s applicants) and undergraduate students. Our research is quite multidisciplinary, involving researchers from a wide range of background including engineering (chemical, mechanical, biomedical, electrical and bioengineering), applied physics, biophysics, material science and applied mathematics. Along with frequently publishing our research, we actively explore platforms to commercialize the technologies that are developed in our lab.
If you are interested in joining our lab, please send a copy of recent CV, a brief summary of your projects and a short statement of your research interests to email@example.com.
PhD, Texas A&M University, Texas, USA, 2015 (Chemical Engineering)
BE, Vellore Institute of Technology, India, 2009 (Chemical Engineering)
2008 -2009 Research Scientist, Bhabha Atomic Research Center, Mumbai, India
2015 -2018 Postdoctoral Fellow, Sandia National Laboratories, Livermore, CA, USA
Grant: #R40526 Investigators:Chae, Soryong; Prasath, Surya; Priye, Aashish 10-01-2019 -03-31-2020 UC's Urban Futures Digital Futures Anchor Development Program Drone-based DNA Analysis Role:PI $10,000.00 Active Level:Internal UC
Peer Reviewed Publications
Priye, Aashish; Hassan, Yassin A.; Ugaz, Victor M. (2012. ) Education: DNA replication using microscale natural convection .Lab on a chip, ,
Priye, Aashish; Ugaz, Victor M (2016. ) Convective PCR Thermocycling with Smartphone-Based Detection: A Versatile Platform for Rapid, Inexpensive, and Robust Mobile Diagnostics .Microfluidic Methods for Molecular Biology, , 55-69
Priye, Aashish; Ball, Cameron S; Meagher, Robert J (2018. ) Colorimetric-Luminance Readout for Quantitative Analysis of Fluorescence Signals with a Smartphone CMOS Sensor .Analytical chemistry, ,
Priye, Aashish; Marlow, William H (2013. ) Computations of Lifshitzâ??van der Waals interaction energies between irregular particles and surfaces at all separations for resuspension modelling .Journal of Physics D: Applied Physics, , 46 (42 ) ,425306
Priye, Aashish; Ugaz, Victor M (2017. ) Smartphone-Enabled Detection Strategies for Portable PCR Based Diagnostics .Biosensors and Biodetection: Methods and Protocols Volume 1: Optical-Based Detectors, , 251-266
Priye, Aashish; Hassan, Yassin A; Ugaz, Victor M (2013. ) Microscale chaotic advection enables robust convective DNA replication .Analytical chemistry, , 85 (21 ) ,10536-10541
Priye, Aashish; Wong, Season; Bi, Yuanpeng; Carpio, Miguel; Chang, Jamison; Coen, Mauricio; Cope, Danielle; Harris, Jacob; Johnson, James; Keller, Alexandra (2016. ) Lab-on-a-drone: toward pinpoint deployment of smartphone-enabled nucleic acid-based diagnostics for mobile health care .Analytical chemistry, , 88 (9 ) ,4651-4660
Priye, Aashish; Bird, Sara W; Light, Yooli K; Ball, Cameron S; Negrete, Oscar A; Meagher, Robert J (2017. ) A smartphone-based diagnostic platform for rapid detection of Zika, chikungunya, and dengue viruses .Scientific Reports (Nature Publishing Group), , 7 (9 ) ,4651-4660
Priye, Aashish; Yu, Yuncheng; Hassan, Yassin A; Ugaz, Victor M (2017. ) Synchronized chaotic targeting and acceleration of surface chemistry in prebiotic hydrothermal microenvironments .Proceedings of the National Academy of Sciences, , 114 (6 ) ,1275-1280
Priye, Aashish; Ugaz, Victor M (2016 ) Convective PCR Thermocycling with Smartphone-Based Detection: A Versatile Platform for Rapid, Inexpensive, and Robust Mobile Diagnostics (pp. 55-69).
Priye, Aashish; Ugaz, Victor M (2017 ) Smartphone-Enabled Detection Strategies for Portable PCRâ??Based Diagnostics Biosensors and Biodetection: Methods and Protocols Volume 1: Optical-Based Detectors .(pp. 251-266).
2017 Far West Federal Science Award Outstanding Technology Development (SmartLAMP)
2015 Phillips 66 Fellowhip Scholarly Research
2014 BASF Outstanding Research Award
2015 Distinguished Doctoral Dissertation Award Texas A&M University
2016 Annual Research Recognition Award Sandia National Laboratories
2014 Chemical Engineering Best Presentation Award Graduate Student Association of Chemical Engineering
2014 Aggie Challenge Engineering Showcase Award Lab on a Drone
2013 Oral Presentation Award Texas A&M University Student Research Week
2009 Merit Scholarship Vellore Institute of Technology