Nancy Ratner

Nancy Ratner, PhD, is interested in understanding mechanisms of peripheral nerve tumor (neurofibroma) formation in neurofibromatosis type 1 (NF1), a common inherited disorder in which children are predisposed to cancer of the nervous system, to learning problems, bone disorders, and other cancers. She identified EGFR and MEK as potential therapeutic targets in NF1 peripheral nerve tumorigenesis, and has developed cell culture and mouse models of NF1 nerve tumorigenesis. Her laboratory has also used analysis of gene expression to identify critical genes in neurofibroma and their malignant derivatives, MPNST.

https://www.cincinnatichildrens.org/research/divisions/e/ex-hem/labs/ratner/default/
 

Neurofibromatosis type 1, NF-1, is a common inherited disease of humans. Patients with NF-1develop a variety of symptoms, the most common of which are peripheral nerve tumors made up largely of Schwann cells, fibroblasts, and extracellular matrix. Neurofibromas develop sporadically in NF-1 patients, suggesting that mutations in the NF-1 gene cause only a predisposition to formation of tumors, which are then triggered by additional, or ''secondary'' genetic or epigenetic events. We have defined cellular abnormalities in neurofibroma cells. To understand the sequence of events which leads to neurofibroma formation, we test whether each of these abnormalities is a direct consequence of the NF-1 mutation. Experiments in progress use mice with targeted NF1 mutations, and primary cells from human tumors. These experiments will identify steps in formation of neurofibromas which could be useful in the development of clinical treatment of NF-1. Furthermore, as the NF1 gene product is a GTPase activating protein toward Ras, we are intersted in the relevance of blocking Ras activation as a method for reversing cellular phenotypes in cells that lack NF1, and ultimately for treating human NF1 patients.

Investigators:Ratner, Nancy 07-15-2002 -07-14-2005 Department of the Army Driving Neurofibroma Formation in Mice Role:PI $706,506.00 Closed Level:Federal

Investigators:Ratner, Nancy 02-01-2004 -01-31-2007 Department of Defense Therapeutic Targets for Neurofibromatosis Role:PI $1,319,843.00 Closed Level:Federal

Investigators:Ratner, Nancy 03-20-2001 -02-28-2005 National Institute of Neurological Disorders and Stroke Mitogenic Activities in Neurofibromatosis Role:PI $1,353,837.00 Closed Level:Federal

Investigators:Ratner, Nancy 04-01-2001 -03-31-2005 National Multiple Sclerosis Society NF1 Signaling in Progenitor Cells Role:PI $329,171.00 Closed Level:Private Non-Profit

Investigators:Ratner, Nancy 08-15-2001 -08-14-2004 Department of the Army Neurofibroma Schwann Cell Gene Expression Analysis Role:PI $306,000.00 Closed Level:Federal

Grant: #5-R01-NS-28840-10-A0-S0-E0 Investigators:Ratner, Nancy 01-01-1996 -12-31-2000 National Institute of Neurological Disorders and Stroke Mitogenic Activities in Neurofibromatosis Role:PI $1,119,141.00 Closed Level:Federal

Grant: #DAMD17-97-1-7348-03-A0-S0-E0 Investigators:Ratner, Nancy 09-15-1997 -07-14-2001 Department of the Army Wounding-Induced Manifestations of Type 1 Neurofibromatosis Role:PI $713,378.00 Closed Level:Federal

Peer Reviewed Publications

Fisher, Michael J; Belzberg, Allan J; de Blank, Peter; De Raedt, Thomas; Elefteriou, Florent; Ferner, Rosalie E; Giovannini, Marco; Harris, Gordon J; Kalamarides, Michel; Karajannis, Matthias A; Kim, AeRang; Lázaro, Conxi; Le, Lu Q; Li, Wei; Listernick, Robert; Martin, Staci; Morrison, Helen; Pasmant, Eric; Ratner, Nancy; Schorry, Elisabeth; Ullrich, Nicole J; Viskochil, David; Weiss, Brian; Widemann, Brigitte C; Zhu, Yuan; Bakker, Annette; Serra, Eduard (2018. ) 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.American journal of medical genetics. Part A, , 176 (5 ) ,1258-1269 More Information

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard (2018. ) Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.Cancer cell, , 33 (2 ) ,292-308.e7 More Information

Titus, Haley E; López-Juárez, Alejandro; Silbak, Sadiq H; Rizvi, Tilat A; Bogard, Madeleine; Ratner, Nancy (2017. ) Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK, nitric oxide, and notch signaling.Glia, , 65 (12 ) ,1990-2002 More Information

Maertens, Ophélia; McCurrach, Mila E; Braun, Benjamin S; De Raedt, Thomas; Epstein, Inbal; Huang, Tannie Q; Lauchle, Jennifer O; Lee, Hyerim; Wu, Jianqiang; Cripe, Timothy P; Clapp, D Wade; Ratner, Nancy; Shannon, Kevin; Cichowski, Karen (2017. ) A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies.Cancer research, , 77 (21 ) ,5706-5711 More Information

Reilly, Karlyne M; Kim, AeRang; Blakely, Jaishri; Ferner, Rosalie E; Gutmann, David H; Legius, Eric; Miettinen, Markku M; Randall, R Lor; Ratner, Nancy; Jumbé, N L; Bakker, Annette; Viskochil, David; Widemann, Brigitte C; Stewart, Douglas R (2017. ) Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.Journal of the National Cancer Institute, , 109 (8 ) , More Information

Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda (2018. ) Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells.Oncotarget, , 9 (22 ) ,15860-15875 More Information

Haworth, Kellie B; Arnold, Michael A; Pierson, Christopher R; Choi, Kwangmin; Yeager, Nicholas D; Ratner, Nancy; Roberts, Ryan D; Finlay, Jonathan L; Cripe, Timothy P (2017. ) Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy.Oncotarget, , 8 (47 ) ,82037-82048 More Information

López-Juárez, Alejandro; Titus, Haley E; Silbak, Sadiq H; Pressler, Joshua W; Rizvi, Tilat A; Bogard, Madeleine; Bennett, Michael R; Ciraolo, Georgianne; Williams, Michael T; Vorhees, Charles V; Ratner, Nancy (2017. ) Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior.Cell reports, , 19 (3 ) ,545-557 More Information

Currier, Mark A; Sprague, Les; Rizvi, Tilat A; Nartker, Brooke; Chen, Chun-Yu; Wang, Pin-Yi; Hutzen, Brian J; Franczek, Meghan R; Patel, Ami V; Chaney, Katherine E; Streby, Keri A; Ecsedy, Jeffrey A; Conner, Joe; Ratner, Nancy; Cripe, Timothy P (2017. ) Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.Oncotarget, , 8 (11 ) ,17412-17427 More Information

Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy (2017. ) An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.Scientific reports, , 7 ,43315 More Information

Dombi, Eva; Baldwin, Andrea; Marcus, Leigh J; Fisher, Michael J; Weiss, Brian; Kim, AeRang; Whitcomb, Patricia; Martin, Staci; Aschbacher-Smith, Lindsey E; Rizvi, Tilat A; Wu, Jianqiang; Ershler, Rachel; Wolters, Pamela; Therrien, Janet; Glod, John; Belasco, Jean B; Schorry, Elizabeth; Brofferio, Alessandra; Starosta, Amy J; Gillespie, Andrea; Doyle, Austin L; Ratner, Nancy; Widemann, Brigitte C (2016. ) Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.The New England journal of medicine, , 375 (26 ) ,2550-2560 More Information

Kendall, Jed J; Chaney, Katherine E; Patel, Ami V; Rizvi, Tilat A; Largaespada, David A; Ratner, Nancy (2016. ) CK2 blockade causes MPNST cell apoptosis and promotes degradation of ?-catenin.Oncotarget, , 7 (33 ) ,53191-53203 More Information

Ratner, Nancy; Brodeur, Garrett M; Dale, Russell C; Schor, Nina F (2016. ) The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.Annals of neurology, , 80 (1 ) ,13-23 More Information

Patel, Ami V; Chaney, Katherine E; Choi, Kwangmin; Largaespada, David A; Kumar, Ashish R; Ratner, Nancy (2016. ) An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.EBioMedicine, , 9 ,110-119 More Information

Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy (2016. ) Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation.Cell reports, , 14 (8 ) ,1979-90 More Information

Angelika Ihle, Michaela; Merkelbach-Bruse, Sabine; Hartmann, Wolfgang; Bauer, Sebastian; Ratner, Nancy; Sonobe, Hiroshi; Nishio, Jun; Larsson, Olle; Åman, Pierre; Pedeutour, Florence; Taguchi, Takahiro; Wardelmann, Eva; Buettner, Reinhard; Schildhaus, Hans-Ulrich (2016. ) HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat.The journal of pathology. Clinical research, , 2 (2 ) ,59-71 More Information

Eiymo Mwa Mpollo, Marthe-Sandrine; Brandt, Eric B; Shanmukhappa, Shiva Kumar; Arumugam, Paritha I; Tiwari, Swati; Loberg, Anastacia; Pillis, Devin; Rizvi, Tilat; Lindsey, Mark; Jonck, Bart; Carmeliet, Peter; Kalra, Vijay K; Le Cras, Timothy D; Ratner, Nancy; Wills-Karp, Marsha; Hershey, Gurjit K Khurana; Malik, Punam (2016. ) Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13.The Journal of clinical investigation, , 126 (2 ) ,571-84 More Information

Patel, Ami V; Johansson, Gunnar; Colbert, Melissa C; Dasgupta, Biplab; Ratner, Nancy (2015. ) Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.Neuro-oncology, , 17 (12 ) ,1599-608 More Information

Wu, Jianqiang; Huang, Gang; Ratner, Nancy (2015. ) Runx1: a new driver in neurofibromagenesis.Oncoscience, , 2 (11 ) ,904-5 More Information

Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Janhofer, David; Dombi, Eva; Dunn, Richard S; Kim, Mi-Ok; Masters, Andrea R; Jones, David R; Cripe, Timothy P; Ratner, Nancy (2015. ) Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.Pediatric blood & cancer, , 62 (10 ) ,1709-16 More Information

Ratner, Nancy; Miller, Shyra J (2015. ) A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor.Nature reviews. Cancer, , 15 (5 ) ,290-301 More Information

Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Jankowski, Michael P; Dasgupta, Biplab (2015. ) Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Nature communications, , 6 ,6075 More Information

Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena (2015. ) Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues.American journal of medical genetics. Part A, , 167A (1 ) ,1-10 More Information

Lee, Mary P; Ratner, Nancy; Yutzey, Katherine E (2014. ) Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.BMC genomics, , 15 ,821 More Information

Pooya, Shabnam; Liu, Xiaona; Kumar, V B Sameer; Anderson, Jane; Imai, Fumiyasu; Zhang, Wujuan; Ciraolo, Georgianne; Ratner, Nancy; Setchell, Kenneth D R; Yoshida, Yutaka; Yutaka, Yoshida; Jankowski, Michael P; Dasgupta, Biplab (2014. ) The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.Nature communications, , 5 ,4993 More Information

Rahrmann, Eric P; Moriarity, Branden S; Otto, George M; Watson, Adrienne L; Choi, Kwangmin; Collins, Margaret H; Wallace, Margaret; Webber, Beau R; Forster, Colleen L; Rizzardi, Anthony E; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A (2014. ) Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.The American journal of pathology, , 184 (7 ) ,2082-98 More Information

Watson, Adrienne L; Anderson, Leah K; Greeley, Andrew D; Keng, Vincent W; Rahrmann, Eric P; Halfond, Amanda L; Powell, Natasha M; Collins, Margaret H; Rizvi, Tilat; Moertel, Christopher L; Ratner, Nancy; Largaespada, David A (2014. ) Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.Oncotarget, , 5 (6 ) ,1502-14 More Information

Ehrman, Lisa A; Nardini, Diana; Ehrman, Sarah; Rizvi, Tilat A; Gulick, James; Krenz, Maike; Dasgupta, Biplab; Robbins, Jeffrey; Ratner, Nancy; Nakafuku, Masato; Waclaw, Ronald R (2014. ) The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 34 (10 ) ,3767-78 More Information

Widemann, Brigitte C; Acosta, Maria T; Ammoun, Sylvia; Belzberg, Allan J; Bernards, Andre; Blakeley, Jaishri; Bretscher, Antony; Cichowski, Karen; Clapp, D Wade; Dombi, Eva; Evans, Gareth D; Ferner, Rosalie; Fernandez-Valle, Cristina; Fisher, Michael J; Giovannini, Marco; Gutmann, David H; Hanemann, C Oliver; Hennigan, Robert; Huson, Susan; Ingram, David; Kissil, Joe; Korf, Bruce R; Legius, Eric; Packer, Roger J; McClatchey, Andrea I; McCormick, Frank; North, Kathryn; Pehrsson, Minja; Plotkin, Scott R; Ramesh, Vijaya; Ratner, Nancy; Schirmer, Susann; Sherman, Larry; Schorry, Elizabeth; Stevenson, David; Stewart, Douglas R; Ullrich, Nicole; Bakker, Annette C; Morrison, Helen (2014. ) CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.American journal of medical genetics. Part A, , 164A (3 ) ,563-78 More Information

Guo, Li; Lee, Audrey A; Rizvi, Tilat A; Ratner, Nancy; Kirschner, Lawrence S (2013. ) The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 33 (46 ) ,17967-75 More Information

Guo, Li; Moon, Chandra; Zheng, Yi; Ratner, Nancy (2013. ) Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.Glia, , 61 (11 ) ,1906-21 More Information

Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy (2013. ) Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.Cell reports, , 4 (6 ) ,1197-212 More Information

Rahrmann, Eric P; Watson, Adrienne L; Keng, Vincent W; Choi, Kwangmin; Moriarity, Branden S; Beckmann, Dominic A; Wolf, Natalie K; Sarver, Aaron; Collins, Margaret H; Moertel, Christopher L; Wallace, Margaret R; Gel, Bernat; Serra, Eduard; Ratner, Nancy; Largaespada, David A (2013. ) Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.Nature genetics, , 45 (7 ) ,756-66 More Information

Watson, Adrienne L; Rahrmann, Eric P; Moriarity, Branden S; Choi, Kwangmin; Conboy, Caitlin B; Greeley, Andrew D; Halfond, Amanda L; Anderson, Leah K; Wahl, Brian R; Keng, Vincent W; Rizzardi, Anthony E; Forster, Colleen L; Collins, Margaret H; Sarver, Aaron L; Wallace, Margaret R; Schmechel, Stephen C; Ratner, Nancy; Largaespada, David A (2013. ) Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.Cancer discovery, , 3 (6 ) ,674-89 More Information

Largaespada, David; Ratner, Nancy (2013. ) Interweaving the strands: ?-catenin, an HIV co-receptor, and Schwann cell tumors.Cancer cell, , 23 (3 ) ,269-71 More Information

Plotkin, Scott R; Blakeley, Jaishri O; Evans, D Gareth; Hanemann, C Oliver; Hulsebos, Theo J M; Hunter-Schaedle, Kim; Kalpana, Ganjam V; Korf, Bruce; Messiaen, Ludwine; Papi, Laura; Ratner, Nancy; Sherman, Larry S; Smith, Miriam J; Stemmer-Rachamimov, Anat O; Vitte, Jeremie; Giovannini, Marco (2013. ) Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria.American journal of medical genetics. Part A, , 161A (3 ) ,405-16 More Information

Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy (2013. ) Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.Acta neuropathologica, , 125 (1 ) ,159-68 More Information

Jessen, Walter J; Miller, Shyra J; Jousma, Edwin; Wu, Jianqiang; Rizvi, Tilat A; Brundage, Meghan E; Eaves, David; Widemann, Brigitte; Kim, Mi-Ok; Dombi, Eva; Sabo, Jessica; Hardiman Dudley, Atira; Niwa-Kawakita, Michiko; Page, Grier P; Giovannini, Marco; Aronow, Bruce J; Cripe, Timothy P; Ratner, Nancy (2013. ) MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.The Journal of clinical investigation, , 123 (1 ) ,340-7 More Information

Guo, Li; Moon, Chandra; Niehaus, Karen; Zheng, Yi; Ratner, Nancy (2012. ) Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (48 ) ,17251-61 More Information

Patmore, Deanna M; Welch, Sara; Fulkerson, Patricia C; Wu, Jianqiang; Choi, Kwangmin; Eaves, David; Kordich, Jennifer J; Collins, Margaret H; Cripe, Timothy P; Ratner, Nancy (2012. ) In vivo regulation of TGF-? by R-Ras2 revealed through loss of the RasGAP protein NF1.Cancer research, , 72 (20 ) ,5317-27 More Information

Gutmann, David H; Parada, Luis F; Silva, Alcino J; Ratner, Nancy (2012. ) Neurofibromatosis type 1: modeling CNS dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 32 (41 ) ,14087-93 More Information

Patel, Ami V; Eaves, David; Jessen, Walter J; Rizvi, Tilat A; Ecsedy, Jeffrey A; Qian, Mark G; Aronow, Bruce J; Perentesis, John P; Serra, Eduard; Cripe, Timothy P; Miller, Shyra J; Ratner, Nancy (2012. ) Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.Clinical cancer research : an official journal of the American Association for Cancer Research, , 18 (18 ) ,5020-30 More Information

Acosta, Maria T; Bearden, Carrie E; Castellanos, F Xavier; Castellanos, Xavier F; Cutting, Laurie; Elgersma, Ype; Gioia, Gerard; Gutmann, David H; Lee, Yong-Seok; Legius, Eric; Muenke, Maximillian; North, Kathryn; Parada, Luis F; Ratner, Nancy; Hunter-Schaedle, Kim; Silva, Alcino J (2012. ) The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research.American journal of medical genetics. Part A, , 158A (9 ) ,2225-32 More Information

Keng, Vincent W; Rahrmann, Eric P; Watson, Adrienne L; Tschida, Barbara R; Moertel, Christopher L; Jessen, Walter J; Rizvi, Tilat A; Collins, Margaret H; Ratner, Nancy; Largaespada, David A (2012. ) PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.Cancer research, , 72 (13 ) ,3405-13 More Information

Kalamarides, Michel; Acosta, Maria T; Babovic-Vuksanovic, Dusica; Carpen, Olli; Cichowski, Karen; Evans, D Gareth; Giancotti, Filippo; Hanemann, C Oliver; Ingram, David; Lloyd, Alison C; Mayes, Debra A; Messiaen, Ludwine; Morrison, Helen; North, Kathryn; Packer, Roger; Pan, Duojia; Stemmer-Rachamimov, Anat; Upadhyaya, Meena; Viskochil, David; Wallace, Margret R; Hunter-Schaedle, Kim; Ratner, Nancy (2012. ) Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting.Acta neuropathologica, , 123 (3 ) ,369-80 More Information

Wu, Jianqiang; Dombi, Eva; Jousma, Edwin; Scott Dunn, R; Lindquist, Diana; Schnell, Beverly M; Kim, Mi-Ok; Kim, Aerang; Widemann, Brigitte C; Cripe, Timothy P; Ratner, Nancy (2012. ) Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.Pediatric blood & cancer, , 58 (2 ) ,173-80 More Information

Keng, Vincent W; Watson, Adrienne L; Rahrmann, Eric P; Li, Hua; Tschida, Barbara R; Moriarity, Branden S; Choi, Kwangmin; Rizvi, Tilat A; Collins, Margaret H; Wallace, Margaret R; Ratner, Nancy; Largaespada, David A (2012. ) Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.Sarcoma, , 2012 ,620834 More Information

Yang, Jilong; Ylipää, Antti; Sun, Yan; Zheng, Hong; Chen, Kexin; Nykter, Matti; Trent, Jonathan; Ratner, Nancy; Lev, Dina C; Zhang, Wei (2011. ) Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment.Clinical cancer research : an official journal of the American Association for Cancer Research, , 17 (24 ) ,7563-73 More Information

Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda (2011. ) Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.Molecular cancer therapeutics, , 10 (9 ) ,1740-50 More Information

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi (2011. ) R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.The Journal of biological chemistry, , 286 (27 ) ,24068-78 More Information

Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy (2011. ) Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.Cancer research, , 71 (13 ) ,4675-85 More Information

Hummel, Trent R; Jessen, Walter J; Miller, Shyra J; Kluwe, Lan; Mautner, Victor F; Wallace, Margaret R; Lázaro, Conxi; Page, Grier P; Worley, Paul F; Aronow, Bruce J; Schorry, Elizabeth K; Ratner, Nancy (2010. ) Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.Clinical cancer research : an official journal of the American Association for Cancer Research, , 16 (20 ) ,5048-57 More Information

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut (2010. ) Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nature medicine, , 16 (10 ) ,1141-6 More Information

Kissil, Joseph L; Blakeley, Jaishri O; Ferner, Rosalie E; Huson, Susan M; Kalamarides, Michel; Mautner, Victor-Felix; McCormick, Frank; Morrison, Helen; Packer, Roger; Ramesh, Vijaya; Ratner, Nancy; Rauen, Katherine A; Stevenson, David A; Hunter-Schaedle, Kim; North, Kathryn (2010. ) What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers.American journal of medical genetics. Part A, , 152A (2 ) ,269-83 More Information

Miller, Shyra J; Jessen, Walter J; Mehta, Tapan; Hardiman, Atira; Sites, Emily; Kaiser, Sergio; Jegga, Anil G; Li, Hua; Upadhyaya, Meena; Giovannini, Marco; Muir, David; Wallace, Margaret R; Lopez, Eva; Serra, Eduard; Nielsen, G Petur; Lazaro, Conxi; Stemmer-Rachamimov, Anat; Page, Grier; Aronow, Bruce J; Ratner, Nancy (2009. ) Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene.EMBO molecular medicine, , 1 (4 ) ,236-48 More Information

Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P (2009. ) Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus.PloS one, , 4 (1 ) ,e4235 More Information

Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy (2008. ) Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Cell stem cell, , 3 (6 ) ,658-69 More Information

Carroll, Steven L; Ratner, Nancy (2008. ) How does the Schwann cell lineage form tumors in NF1?.Glia, , 56 (14 ) ,1590-605 More Information

Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy (2008. ) Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.Molecular cancer therapeutics, , 7 (5 ) ,1237-45 More Information

Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy (2008. ) Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.Cancer cell, , 13 (2 ) ,105-16 More Information

Monk, Kelly R; Wu, Jianqiang; Williams, Jon P; Finney, Brenda A; Fitzgerald, Maureen E; Filippi, Marie-Dominique; Ratner, Nancy (2007. ) Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve.Neuron glia biology, , 3 (3 ) ,233-44 More Information

Mahller, Yonatan Y; Vaikunth, Sachin S; Currier, Mark A; Miller, Shyra J; Ripberger, Maria C; Hsu, Ya-Hsuan; Mehrian-Shai, Ruty; Collins, Margaret H; Crombleholme, Timothy M; Ratner, Nancy; Cripe, Timothy P (2007. ) Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model.Molecular therapy : the journal of the American Society of Gene Therapy, , 15 (2 ) ,279-86 More Information

Mahller, Yonatan Y; Rangwala, Fatima; Ratner, Nancy; Cripe, Timothy P (2006. ) Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants.Pediatric blood & cancer, , 46 (7 ) ,745-54 More Information

Wu, Jianqiang; Crimmins, Jason T; Monk, Kelly R; Williams, Jon P; Fitzgerald, Maureen E; Tedesco, Susan; Ratner, Nancy (2006. ) Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.The American journal of pathology, , 168 (5 ) ,1686-96 More Information

Nakai, Yoko; Zheng, Yi; MacCollin, Mia; Ratner, Nancy (2006. ) Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 26 (13 ) ,3390-5 More Information

Miller, Shyra J; Rangwala, Fatima; Williams, Jon; Ackerman, Peter; Kong, Sue; Jegga, Anil G; Kaiser, Sergio; Aronow, Bruce J; Frahm, Silke; Kluwe, Lan; Mautner, Victor; Upadhyaya, Meena; Muir, David; Wallace, Margaret; Hagen, Jussara; Quelle, Dawn E; Watson, Mark A; Perry, Arie; Gutmann, David H; Ratner, Nancy (2006. ) Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.Cancer research, , 66 (5 ) ,2584-91 More Information

Ratner, Nancy; Williams, Jon P; Kordich, Jennifer J; Kim, Haesun A (2006. ) Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells.Methods in enzymology, , 407 ,22-33 More Information

Aguirre, Adan; Rizvi, Tilat A; Ratner, Nancy; Gallo, Vittorio (2005. ) Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 25 (48 ) ,11092-106 More Information

Ling, Benjamin C; Wu, Jianqiang; Miller, Shyra J; Monk, Kelly R; Shamekh, Rania; Rizvi, Tilat A; Decourten-Myers, Gabrielle; Vogel, Kristine S; DeClue, Jeffrey E; Ratner, Nancy (2005. ) Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.Cancer cell, , 7 (1 ) ,65-75 More Information

Tang, Yang; Lu, Aigang; Ran, Ruiqiong; Aronow, Bruce J; Schorry, Elizabeth K; Hopkin, Robert J; Gilbert, Donald L; Glauser, Tracy A; Hershey, Andrew D; Richtand, Neil W; Privitera, Michael; Dalvi, Arif; Sahay, Alok; Szaflarski, Jerzy P; Ficker, David M; Ratner, Nancy; Sharp, Frank R (2004. ) Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1.Brain research. Molecular brain research, , 132 (2 ) ,155-67 More Information

Corfas, Gabriel; Velardez, Miguel Omar; Ko, Chien-Ping; Ratner, Nancy; Peles, Elior (2004. ) Mechanisms and roles of axon-Schwann cell interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 24 (42 ) ,9250-60 More Information

Stemmer-Rachamimov, Anat O; Louis, David N; Nielsen, Gunnlaugur P; Antonescu, Cristina R; Borowsky, Alexander D; Bronson, Roderick T; Burns, Dennis K; Cervera, Pascale; McLaughlin, Margaret E; Reifenberger, Guido; Schmale, Michael C; MacCollin, Mia; Chao, Richard C; Cichowski, Karen; Kalamarides, Michel; Messerli, Shanta M; McClatchey, Andrea I; Niwa-Kawakita, Michiko; Ratner, Nancy; Reilly, Karlyne M; Zhu, Yuan; Giovannini, Marco (2004. ) Comparative pathology of nerve sheath tumors in mouse models and humans.Cancer research, , 64 (10 ) ,3718-24 More Information

Stickney, John T; Bacon, W Clark; Rojas, Meghan; Ratner, Nancy; Ip, Wallace (2004. ) Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer research, , 64 (8 ) ,2717-24

Huang, Yuan; Rangwala, Fatima; Fulkerson, Patricia C; Ling, Bo; Reed, Erin; Cox, Adrienne D; Kamholz, John; Ratner, Nancy (2004. ) Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.Oncogene, , 23 (2 ) ,368-78 More Information

Yang, Feng-Chun; Ingram, David A; Chen, Shi; Hingtgen, Cynthia M; Ratner, Nancy; Monk, Kelly R; Clegg, Travis; White, Hilary; Mead, Laura; Wenning, Mary Jo; Williams, David A; Kapur, Reuben; Atkinson, Simon J; Clapp, D Wade (2003. ) Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.The Journal of clinical investigation, , 112 (12 ) ,1851-61 More Information

Bennett, Michael R; Rizvi, Tilat A; Karyala, Saikumar; McKinnon, Randall D; Ratner, Nancy (2003. ) Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 23 (18 ) ,7207-17

Manent, Jan; Oguievetskaia, Ksenia; Bayer, Jan; Ratner, Nancy; Giovannini, Marco (2003. ) Magnetic cell sorting for enriching Schwann cells from adult mouse peripheral nerves. Journal of neuroscience methods, , 123 (2 ) ,167-73

Miller, Shyra J; Li, Hongzhen; Rizvi, Tilat A; Huang, Yuan; Johansson, Gunnar; Bowersock, Jason; Sidani, Amer; Vitullo, John; Vogel, Kristine; Parysek, Linda M; DeClue, Jeffrey E; Ratner, Nancy (2003. ) Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Molecular and cellular biology, , 23 (6 ) ,2213-24

Rizvi, Tilat A; Huang, Yuan; Sidani, Amer; Atit, Radhika; Largaespada, David A; Boissy, Raymond E; Ratner, Nancy (2002. ) A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 22 (22 ) ,9831-40

Xu, Yanfang; Chiamvimonvat, Nipavan; Vázquez, Ana E; Akunuru, Shailaja; Ratner, Nancy; Yamoah, Ebenezer N (2002. ) Gene-targeted deletion of neurofibromin enhances the expression of a transient outward K+ current in Schwann cells: a protein kinase A-mediated mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 22 (21 ) ,9194-202

Morfini, Gerardo; Szebenyi, Györgyi; Elluru, Ravindhra; Ratner, Nancy; Brady, Scott T (2002. ) Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility.The EMBO journal, , 21 (3 ) ,281-93 More Information

Bashour, Anne-Marie; Meng, J-J; Ip, Wallace; MacCollin, Mia; Ratner, Nancy (2002. ) The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells. Molecular and cellular biology, , 22 (4 ) ,1150-7

Rosenbaum, Thorsten; Kim, Haesun A; Boissy, Ying L; Ling, B O; Ratner, Nancy (1999. ) Neurofibromin, the Neurofibromatosis Type 1 Ras-GAP, Is Required for Appropriate P0 Expression and Myelination.Annals of the New York Academy of Sciences, , 883 (1 ) ,203-214 More Information

Mitogen,Mutation,Chick Embryo,Schwann Cell,Human Subject,Laboratory Rat,Cellular Oncology,Laboratory Rabbit,Neurofibromatosis,Immunocytochemistry,Neurotrophic Factor,Tissue Cell Culture,In Situ Hybridization,Cell Growth Regulation,Fibroblast Growth Factor,Neoplasm Cancer Genetics,Peripheral Nervous System,Ras

Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229
Phone: 513-636-9469
Fax: 513-636-3549
nancy.ratner@cchmc.org