John F Reichard

Computational Toxicology and Risk Assessment

Ph.D.: University of Colorado Denver, (Toxicology)

Pharm.D.: University of Kentucky Lexington, (Pharmacy)

Grant: #U01HL111638 Investigators:Medvedovic, Mario; Reichard, John; Sivaganesan, Siva 09-24-2011 -06-30-2014 National Heart, Lung and Blood Institute Integrative Statistical Methods and Tools for Analysis of Perturbation Signatures Role:Collaborator $1,111,422.00 Active Level:Federal

Grant: #18IPA1816739 sub CDC Investigators:Reichard, John 09-01-2018 -08-31-2019 Centers for Disease Control and Prevention Intergovernmental Personnel Act Agreement for John Reichard Role:PI $33,500.00 Active Level:Federal

Grant: #R24ES028527 Investigators:Leung, Yuet Kin; Pinney, Susan; Reichard, John; Xie, Changchun 09-30-2018 -06-30-2023 National Institute of Environmental Health Sciences Fernald Community Cohort: Research Resource for Environmental Epidemiology Role:Collaborator $399,875.00 Active Level:Federal

Grant: #Pharmaceutics Strategist IPA / PO #NNJ20OB11P Investigators:Reichard, John 08-01-2020 -07-31-2022 NASA Chief Health and Medical Office NASA IPA Role:PI $211,408.50 Awarded Level:Federal

Grant: #T42 OH008432 Investigators:Bhattacharya, Amit; Bloomer, Jessica; Davis, Kermit; Freeman, Andrew; Gillespie, Gordon; Kim, Jay; Reichard, John; Reponen, Tiina 07-01-2021 -06-30-2026 Centers for Disease Control and Prevention Education and Research Center (ERC - Cincinnati) Role:Collaborator 1800000.00 Hold Level:Federal

Grant: #SUBK00013824 / R25ES033042 Investigators:Bloomer, Jessica; Davis, Kermit; Gillespie, Gordon; Haber, Lynne; Reichard, John; Reponen, Tiina; Wang, Jun 09-01-2021 -08-31-2026 National Institute of Environmental Health Sciences Michigan-Ohio Occupational Research Education (MOORE) Program Role:Collaborator 89613.00 Hold Level:Federal

Grant: #Reichard IPA Ext. 08-01-2022 -07-31-2024 NASA Headquarters NASA - IPA Role:PI 0.00 Hold Level:Federal

Grant: #Reichard IPA Ext. 08-01-2022 -07-31-2024 NASA Headquarters NASA - IPA Role:PI 0.00 Hold Level:Federal

Grant: #SUBK00013824 / R25ES033042 Investigators:Bloomer, Jessica; Davis, Kermit; Gillespie, Gordon; Haber, Lynne; Reichard, John; Reponen, Tiina; Wang, Jun 09-01-2021 -08-31-2026 National Institute of Environmental Health Sciences Michigan-Ohio Occupational Research Education (MOORE) Program Role:Collaborator 177216.00 Active Level:Federal

09-01-2023 -08-31-2024 Centers for Disease Control and Prevention IPA/NIOSH FY 24 Role:PI 0.00 Hold Level:Federal

09-01-2023 -08-31-2024 Centers for Disease Control and Prevention IPA/NIOSH FY 24 Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Budinsky, R A; Schrenk, D; Simon, T; Van den Berg, M; Reichard, J F; Silkworth, J B; Aylward, L L; Brix, A; Gasiewicz, T; Kaminski, N; Perdew, G; Starr, T B; Walker, N J; Rowlands, J C (2014. ) Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study.Critical reviews in toxicology, , 44 (1 ) ,83-119 More Information

States, J Christopher; Barchowsky, Aaron; Cartwright, Iain L; Reichard, John F; Futscher, Bernard W; Lantz, R Clark (2011. ) Arsenic toxicology: translating between experimental models and human pathology.Environmental health perspectives, , 119 (10 ) ,1356-63 More Information

Reichard, John F; Puga, Alvaro (2010. ) Effects of arsenic exposure on DNA methylation and epigenetic gene regulation.Epigenomics, , 2 (1 ) ,87-104 More Information

Sartor, Maureen A; Schnekenburger, Michael; Marlowe, Jennifer L; Reichard, John F; Wang, Ying; Fan, Yunxia; Ma, Ci; Karyala, Saikumar; Halbleib, Danielle; Liu, Xiangdong; Medvedovic, Mario; Puga, Alvaro (2009. ) Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.Environmental health perspectives, , 117 (7 ) ,1139-46 More Information

Reichard, John F; Sartor, Maureen A; Puga, Alvaro (2008. ) BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.The Journal of biological chemistry, , 283 (33 ) ,22363-70 More Information

Reichard, John F; Schnekenburger, Michael; Puga, Alvaro (2007. ) Long term low-dose arsenic exposure induces loss of DNA methylation.Biochemical and biophysical research communications, , 352 (1 ) ,188-92 More Information

Reichard, John F; Motz, Gregory T; Puga, Alvaro (2007. ) Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.Nucleic acids research, , 35 (21 ) ,7074-86 More Information

Reichard, John F; Dalton, Timothy P; Shertzer, Howard G; Puga, Alvaro (2005. ) Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.Dose-response : a publication of International Hormesis Society, , 3 (3 ) ,306-31 More Information

Reichard, John F; Petersen, Dennis R (2006. ) Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation.Archives of biochemistry and biophysics, , 446 (2 ) ,111-8 More Information

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro (2005. ) Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.Toxicological sciences : an official journal of the Society of Toxicology, , 87 (2 ) ,365-84 More Information

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro (2005. ) Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes.Molecular pharmacology, , 68 (2 ) ,336-46 More Information

Reichard, John F; Petersen, Dennis R (2004. ) Hepatic stellate cells lack AP-1 responsiveness to electrophiles and phorbol 12-myristate-13-acetate.Biochemical and biophysical research communications, , 322 (3 ) ,842-53 More Information

Reichard, John F; Doorn, Jonathan A; Simon, Franz; Taylor, Melinda S; Petersen, Dennis R (2003. ) Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Archives of biochemistry and biophysics, , 411 (2 ) ,243-50

Reichard, J F; Vasiliou, V; Petersen, D R (2000. ) Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Biochimica et biophysica acta, , 1487 (2-3 ) ,222-32

Dourson, Michael; Reichard, John; Nance, Patricia; Burleigh-Flayer, Heather; Parker, Ann; Vincent, Melissa; McConnell, Ernest E (2014. ) Mode of action analysis for liver tumors from oral 1,4-dioxane exposures and evidence-based dose response assessment.Regulatory toxicology and pharmacology : RTP, , 68 (3 ) ,387-401 More Information

Chen, Jing; Hu, Zhen; Phatak, Mukta; Reichard, John; Freudenberg, Johannes M; Sivaganesan, Siva; Medvedovic, Mario (2013. ) Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules.PLoS computational biology, , 9 (9 ) ,e1003198 More Information

Muñoz-Garcia, Agustí; Ro, Jennifer; Reichard, Jonathan D; Kunz, Thomas H; Williams, Joseph B (2012. ) Cutaneous water loss and lipids of the stratum corneum in two syntopic species of bats.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, , 161 (2 ) ,208-15 More Information

Reichard, Jonathan D; Prajapati, Suresh I; Austad, Steven N; Keller, Charles; Kunz, Thomas H (2010. ) Thermal windows on Brazilian free-tailed bats facilitate thermoregulation during prolonged flight.Integrative and comparative biology, , 50 (3 ) ,358-70 More Information

Hartley, D P; Kolaja, K L; Reichard, J; Petersen, D R (1999. ) 4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization.Toxicology and applied pharmacology, , 161 (1 ) ,23-33 More Information

Reichard, John F; Haber, Lynne T (2016. ) Mode-of-action evaluation for the effect of trans fatty acids on low-density lipoprotein cholesterol.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , 98 (Pt B ) ,282-294 More Information

Reichard, John F; Maier, M Andrew; Naumann, Bruce D; Pecquet, Alison M; Pfister, Thomas; Sandhu, Reena; Sargent, Edward V; Streeter, Anthony J; Weideman, Patricia A (2016. ) Toxicokinetic and toxicodynamic considerations when deriving health-based exposure limits for pharmaceuticals.Regulatory toxicology and pharmacology : RTP, , 79 Suppl 1 ,S67-78 More Information

Frank, Evan; Ishau, Simileoluwa; Maier, Andrew; Reutman, Susan; Reichard, John F (2019. ) An occupational exposure limit (OEL) approach to protect home healthcare workers exposed to common nebulized drugs.Regulatory toxicology and pharmacology : RTP, , 106 ,251-261 More Information

Keenan, Alexandra B; Jenkins, Sherry L; Jagodnik, Kathleen M; Koplev, Simon; He, Edward; Torre, Denis; Wang, Zichen; Dohlman, Anders B; Silverstein, Moshe C; Lachmann, Alexander; Kuleshov, Maxim V; Ma'ayan, Avi; Stathias, Vasileios; Terryn, Raymond; Cooper, Daniel; Forlin, Michele; Koleti, Amar; Vidovic, Dusica; Chung, Caty; Schürer, Stephan C; Vasiliauskas, Jouzas; Pilarczyk, Marcin; Shamsaei, Behrouz; Fazel, Mehdi; Ren, Yan; Niu, Wen; Clark, Nicholas A; White, Shana; Mahi, Naim; Zhang, Lixia; Kouril, Michal; Reichard, John F; Sivaganesan, Siva; Medvedovic, Mario; Meller, Jaroslaw; Koch, Rick J; Birtwistle, Marc R; Iyengar, Ravi; Sobie, Eric A; Azeloglu, Evren U; Kaye, Julia; Osterloh, Jeannette; Haston, Kelly; Kalra, Jaslin; Finkbiener, Steve; Li, Jonathan; Milani, Pamela; Adam, Miriam; Escalante-Chong, Renan; Sachs, Karen; Lenail, Alex; Ramamoorthy, Divya; Fraenkel, Ernest; Daigle, Gavin; Hussain, Uzma; Coye, Alyssa; Rothstein, Jeffrey; Sareen, Dhruv; Ornelas, Loren; Banuelos, Maria; Mandefro, Berhan; Ho, Ritchie; Svendsen, Clive N; Lim, Ryan G; Stocksdale, Jennifer; Casale, Malcolm S; Thompson, Terri G; Wu, Jie; Thompson, Leslie M; Dardov, Victoria; Venkatraman, Vidya; Matlock, Andrea; Van Eyk, Jennifer E; Jaffe, Jacob D; Papanastasiou, Malvina; Subramanian, Aravind; Golub, Todd R; Erickson, Sean D; Fallahi-Sichani, Mohammad; Hafner, Marc; Gray, Nathanael S; Lin, Jia-Ren; Mills, Caitlin E; Muhlich, Jeremy L; Niepel, Mario; Shamu, Caroline E; Williams, Elizabeth H; Wrobel, David; Sorger, Peter K; Heiser, Laura M; Gray, Joe W; Korkola, James E; Mills, Gordon B; LaBarge, Mark; Feiler, Heidi S; Dane, Mark A; Bucher, Elmar; Nederlof, Michel; Sudar, Damir; Gross, Sean; Kilburn, David F; Smith, Rebecca; Devlin, Kaylyn; Margolis, Ron; Derr, Leslie; Lee, Albert; Pillai, Ajay (2018. ) The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.Cell systems, , 6 (1 ) ,13-24 More Information

Haber, Lynne T; Reichard, John F; Henning, Alice K; Dawson, Peter; Chinthrajah, R Sharon; Sindher, Sayantani B; Long, Andrew; Vincent, Melissa J; Nadeau, Kari C; Allen, Bruce C (2021. ) Bayesian hierarchical evaluation of dose-response for peanut allergy in clinical trial screening.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , 151 ,112125 More Information

Juarez, Paul D; Tabatabai, Mohammad; Valdez, Robert Burciaga; Hood, Darryl B; Im, Wansoo; Mouton, Charles; Colen, Cynthia; Al-Hamdan, Mohammad Z; Matthews-Juarez, Patricia; Lichtveld, Maureen Y; Sarpong, Daniel; Ramesh, Aramandla; Langston, Michael A; Rogers, Gary L; Phillips, Charles A; Reichard, John F; Donneyong, Macarius M; Blot, William (2020. ) The Effects of Social, Personal, and Behavioral Risk Factors and PM2.5 on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients.International journal of environmental research and public health, , 17 (10 ) , More Information

Ishau, Simileoluwa; Reichard, John F; Maier, Andrew; Niang, Mamadou; Yermakov, Michael; Grinshpun, Sergey A (2020. ) Estimated dermal exposure to nebulized pharmaceuticals for a simulated home healthcare worker scenario.Journal of occupational and environmental hygiene, , 17 (4 ) ,193-205 More Information

Reichard, J F; Phelps, S E; Lehnhardt, K R; Young, M; Easter, B D (2023. ) The effect of long-term spaceflight on drug potency and the risk of medication failure.NPJ microgravity, , 9 (1 ) ,35 More Information

Niang, Mamadou; Reichard, John F; Maier, Andrew; Talaska, Glenn; Ying, Jun; Santo Domingo, Jorge; Varughese, Eunice; Boczek, Laura; Huff, Emma; Reponen, Tiina (2023. ) Ciprofloxacin- and azithromycin-resistant bacteria in a wastewater treatment plant.Journal of occupational and environmental hygiene, , 20 (5-6 ) ,219-225 More Information

Pilarczyk, Marcin; Fazel-Najafabadi, Mehdi; Kouril, Michal; Shamsaei, Behrouz; Vasiliauskas, Juozas; Niu, Wen; Mahi, Naim; Zhang, Lixia; Clark, Nicholas A; Ren, Yan; White, Shana; Karim, Rashid; Xu, Huan; Biesiada, Jacek; Bennett, Mark F; Davidson, Sarah E; Reichard, John F; Roberts, Kurt; Stathias, Vasileios; Koleti, Amar; Vidovic, Dusica; Clarke, Daniel J B; Schürer, Stephan C; Ma'ayan, Avi; Meller, Jarek; Medvedovic, Mario (2022. ) Connecting omics signatures and revealing biological mechanisms with iLINCS.Nature communications, , 13 (1 ) ,4678 More Information

Niemeier, Richard Todd; Maier, Andrew; Reichard, John F (2022. ) Rapid Review of Dermal Penetration and Absorption of Inorganic Lead Compounds for Occupational Risk Assessment.Annals of work exposures and health, , 66 (3 ) ,291-311 More Information

El-Khoury, Bashir B; Ray, Kristi L; Altchuler, Steven I; Reichard, John F; Dukes, Charles H (2023. ) Selective Serotonin Reuptake Inhibitors and Other Treatment Modalities for Deep Space Missions.Aerospace medicine and human performance, , 94 (11 ) ,843-851 More Information

Jolly, Robert A; Bandara, Suren; Bercu, Joel; Callis, Courtney M; Dolan, David G; Graham, Jessica; HaMai, Diem; Barle, Ester Lovsin; Maier, Andrew; Masuda-Herrera, Melisa; Moudgal, Chandrika; Parker, Jillian A; Reichard, John; Sandhu, Reena; Fung, Ernest S (2022. ) Setting impurity limits for endogenous substances: Recommendations for a harmonized procedure and an example using fatty acids.Regulatory toxicology and pharmacology : RTP, , 134 ,105242 More Information

Symmank, Judit; Bayer, Cathrin; Reichard, Julia; Pensold, Daniel; Zimmer-Bensch, Geraldine (2020. ) Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks.Epigenetics, , 15 (11 ) ,1259-1274 More Information

Cifuentes, Patricia; Reichard, John; Im, Wansoo; Smith, Sakima; Colen, Cynthia; Giurgescu, Carmen; Williams, Karen Patricia; Gillespie, Shannon; Juarez, Paul D; Hood, Darryl B (2019. ) Application of the Public Health Exposome Framework to Estimate Phenotypes of Resilience in a Model Ohio African-American Women's Cohort.Journal of urban health : bulletin of the New York Academy of Medicine, , 96 (Suppl 1 ) ,57-71 More Information

Dourson, Michael L; Higginbotham, Jeri; Crum, Jeff; Burleigh-Flayer, Heather; Nance, Patricia; Forsberg, Norman D; Lafranconi, Mark; Reichard, John (2017. ) Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane.Regulatory toxicology and pharmacology : RTP, , 88 ,45-55 More Information