John F Reichard

Computational Toxicology, Risk Assessment, Exposure Science and Biologic Monitoring

Ph.D.: University of Colorado Denver, CO, (Toxicology)

Pharm.D.: University of Kentucky Lexington, KY, (Pharmacy)

B.S.: University of Wyoming Laramie, WY, (Molecular Biology)

B.S.: University of Wyoming Laramie, WY, (Pharmacy)

08-2015 -09-2022 Assistant Professor (Research Track), University of Cincinnati, Cincinnati, OH

2011 -07-2015 Pharmaceutical Toxicologist, Toxicology Excellence for Risk Assessment , Cincinnati, OH

2009 -2011 Research Associate, University of Cincinnati, Cincinnati, OH

1995 -1997 Director of Pharmacy, LifeTek Home Infusion (Columbia HCA), Lexington, KY

1993 -1995 Clinical Pharmacist, University of Kentucky Medical Center, Lexington, KY

Grant: #U01HL111638 Investigators:Medvedovic, Mario; Reichard, John; Sivaganesan, Siva 09-24-2011 -06-30-2014 National Heart, Lung and Blood Institute Integrative Statistical Methods and Tools for Analysis of Perturbation Signatures Role:Collaborator $1,111,422.00 Active Level:Federal

Grant: #18IPA1816739 sub CDC Investigators:Reichard, John 09-01-2018 -08-31-2019 Centers for Disease Control and Prevention Intergovernmental Personnel Act Agreement for John Reichard Role:PI $33,500.00 Active Level:Federal

Grant: #R24ES028527 Investigators:Leung, Yuet Kin; Pinney, Susan; Reichard, John; Xie, Changchun 09-30-2018 -06-30-2023 National Institute of Environmental Health Sciences Fernald Community Cohort: Research Resource for Environmental Epidemiology Role:Collaborator $399,875.00 Active Level:Federal

Grant: #Pharmaceutics Strategist IPA / PO #NNJ20OB11P Investigators:Reichard, John 08-01-2020 -07-31-2022 NASA Chief Health and Medical Office NASA IPA Role:PI $211,408.50 Awarded Level:Federal

Grant: #T42 OH008432 Investigators:Bhattacharya, Amit; Bloomer, Jessica; Davis, Kermit; Freeman, Andrew; Gillespie, Gordon; Kim, Jay; Reichard, John; Reponen, Tiina 07-01-2021 -06-30-2026 Centers for Disease Control and Prevention Education and Research Center (ERC - Cincinnati) Role:Collaborator 1800000.00 Hold Level:Federal

Grant: #SUBK00013824 / R25ES033042 Investigators:Bloomer, Jessica; Davis, Kermit; Gillespie, Gordon; Haber, Lynne; Reichard, John; Reponen, Tiina; Wang, Jun 09-01-2021 -08-31-2026 National Institute of Environmental Health Sciences Michigan-Ohio Occupational Research Education (MOORE) Program Role:Collaborator 89613.00 Hold Level:Federal

Grant: #Reichard IPA Ext. 08-01-2022 -07-31-2024 NASA Headquarters NASA - IPA Role:PI 0.00 Hold Level:Federal

Grant: #Reichard IPA Ext. 08-01-2022 -07-31-2024 NASA Headquarters NASA - IPA Role:PI 0.00 Hold Level:Federal

Grant: #SUBK00013824 / R25ES033042 Investigators:Bloomer, Jessica; Davis, Kermit; Gillespie, Gordon; Haber, Lynne; Reichard, John; Reponen, Tiina; Wang, Jun 09-01-2021 -08-31-2026 National Institute of Environmental Health Sciences Michigan-Ohio Occupational Research Education (MOORE) Program Role:Collaborator 177216.00 Active Level:Federal

09-01-2023 -08-31-2024 Centers for Disease Control and Prevention IPA/NIOSH FY 24 Role:PI 0.00 Hold Level:Federal

09-01-2023 -08-31-2024 Centers for Disease Control and Prevention IPA/NIOSH FY 24 Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Budinsky, R A; Schrenk, D; Simon, T; Van den Berg, M; Reichard, J F; Silkworth, J B; Aylward, L L; Brix, A; Gasiewicz, T; Kaminski, N; Perdew, G; Starr, T B; Walker, N J; Rowlands, J C  (2014). Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study. Critical reviews in toxicology, 44 (1) , 83-119More Information

States, J Christopher; Barchowsky, Aaron; Cartwright, Iain L; Reichard, John F; Futscher, Bernard W; Lantz, R Clark  (2011). Arsenic toxicology: translating between experimental models and human pathology. Environmental health perspectives, 119 (10) , 1356-63More Information

Reichard, John F; Puga, Alvaro  (2010). Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics, 2 (1) , 87-104More Information

Sartor, Maureen A; Schnekenburger, Michael; Marlowe, Jennifer L; Reichard, John F; Wang, Ying; Fan, Yunxia; Ma, Ci; Karyala, Saikumar; Halbleib, Danielle; Liu, Xiangdong; Medvedovic, Mario; Puga, Alvaro  (2009). Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environmental health perspectives, 117 (7) , 1139-46More Information

Reichard, John F; Sartor, Maureen A; Puga, Alvaro  (2008). BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. The Journal of biological chemistry, 283 (33) , 22363-70More Information

Reichard, John F; Schnekenburger, Michael; Puga, Alvaro  (2007). Long term low-dose arsenic exposure induces loss of DNA methylation. Biochemical and biophysical research communications, 352 (1) , 188-92More Information

Reichard, John F; Motz, Gregory T; Puga, Alvaro  (2007). Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic acids research, 35 (21) , 7074-86More Information

Reichard, John F; Dalton, Timothy P; Shertzer, Howard G; Puga, Alvaro  (2005). Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-response : a publication of International Hormesis Society, 3 (3) , 306-31More Information

Reichard, John F; Petersen, Dennis R  (2006). Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation. Archives of biochemistry and biophysics, 446 (2) , 111-8More Information

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro  (2005). Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 (2) , 365-84More Information

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro  (2005). Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 (2) , 336-46More Information

Reichard, John F; Petersen, Dennis R  (2004). Hepatic stellate cells lack AP-1 responsiveness to electrophiles and phorbol 12-myristate-13-acetate. Biochemical and biophysical research communications, 322 (3) , 842-53More Information

Reichard, John F; Doorn, Jonathan A; Simon, Franz; Taylor, Melinda S; Petersen, Dennis R  (2003). Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Archives of biochemistry and biophysics, 411 (2) , 243-50

Reichard, J F; Vasiliou, V; Petersen, D R  (2000). Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Biochimica et biophysica acta, 1487 (2-3) , 222-32

Dourson, Michael; Reichard, John; Nance, Patricia; Burleigh-Flayer, Heather; Parker, Ann; Vincent, Melissa; McConnell, Ernest E  (2014). Mode of action analysis for liver tumors from oral 1,4-dioxane exposures and evidence-based dose response assessment. Regulatory toxicology and pharmacology : RTP, 68 (3) , 387-401More Information

Chen, Jing; Hu, Zhen; Phatak, Mukta; Reichard, John; Freudenberg, Johannes M; Sivaganesan, Siva; Medvedovic, Mario  (2013). Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. PLoS computational biology, 9 (9) , e1003198More Information

Muñoz-Garcia, Agustí; Ro, Jennifer; Reichard, Jonathan D; Kunz, Thomas H; Williams, Joseph B  (2012). Cutaneous water loss and lipids of the stratum corneum in two syntopic species of bats. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 161 (2) , 208-15More Information

Reichard, Jonathan D; Prajapati, Suresh I; Austad, Steven N; Keller, Charles; Kunz, Thomas H  (2010). Thermal windows on Brazilian free-tailed bats facilitate thermoregulation during prolonged flight. Integrative and comparative biology, 50 (3) , 358-70More Information

Hartley, D P; Kolaja, K L; Reichard, J; Petersen, D R  (1999). 4-Hydroxynonenal and malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization. Toxicology and applied pharmacology, 161 (1) , 23-33More Information

Reichard, John F; Haber, Lynne T  (2016). Mode-of-action evaluation for the effect of trans fatty acids on low-density lipoprotein cholesterol. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 98 (Pt B) , 282-294More Information

Reichard, John F; Maier, M Andrew; Naumann, Bruce D; Pecquet, Alison M; Pfister, Thomas; Sandhu, Reena; Sargent, Edward V; Streeter, Anthony J; Weideman, Patricia A  (2016). Toxicokinetic and toxicodynamic considerations when deriving health-based exposure limits for pharmaceuticals. Regulatory toxicology and pharmacology : RTP, 79 Suppl 1, S67-78More Information

Frank, Evan; Ishau, Simileoluwa; Maier, Andrew; Reutman, Susan; Reichard, John F  (2019). An occupational exposure limit (OEL) approach to protect home healthcare workers exposed to common nebulized drugs. Regulatory toxicology and pharmacology : RTP, 106, 251-261More Information

Keenan, Alexandra B; Jenkins, Sherry L; Jagodnik, Kathleen M; Koplev, Simon; He, Edward; Torre, Denis; Wang, Zichen; Dohlman, Anders B; Silverstein, Moshe C; Lachmann, Alexander; Kuleshov, Maxim V; Ma'ayan, Avi; Stathias, Vasileios; Terryn, Raymond; Cooper, Daniel; Forlin, Michele; Koleti, Amar; Vidovic, Dusica; Chung, Caty; Schürer, Stephan C; Vasiliauskas, Jouzas; Pilarczyk, Marcin; Shamsaei, Behrouz; Fazel, Mehdi; Ren, Yan; Niu, Wen; Clark, Nicholas A; White, Shana; Mahi, Naim; Zhang, Lixia; Kouril, Michal; Reichard, John F; Sivaganesan, Siva; Medvedovic, Mario; Meller, Jaroslaw; Koch, Rick J; Birtwistle, Marc R; Iyengar, Ravi; Sobie, Eric A; Azeloglu, Evren U; Kaye, Julia; Osterloh, Jeannette; Haston, Kelly; Kalra, Jaslin; Finkbiener, Steve; Li, Jonathan; Milani, Pamela; Adam, Miriam; Escalante-Chong, Renan; Sachs, Karen; Lenail, Alex; Ramamoorthy, Divya; Fraenkel, Ernest; Daigle, Gavin; Hussain, Uzma; Coye, Alyssa; Rothstein, Jeffrey; Sareen, Dhruv; Ornelas, Loren; Banuelos, Maria; Mandefro, Berhan; Ho, Ritchie; Svendsen, Clive N; Lim, Ryan G; Stocksdale, Jennifer; Casale, Malcolm S; Thompson, Terri G; Wu, Jie; Thompson, Leslie M; Dardov, Victoria; Venkatraman, Vidya; Matlock, Andrea; Van Eyk, Jennifer E; Jaffe, Jacob D; Papanastasiou, Malvina; Subramanian, Aravind; Golub, Todd R; Erickson, Sean D; Fallahi-Sichani, Mohammad; Hafner, Marc; Gray, Nathanael S; Lin, Jia-Ren; Mills, Caitlin E; Muhlich, Jeremy L; Niepel, Mario; Shamu, Caroline E; Williams, Elizabeth H; Wrobel, David; Sorger, Peter K; Heiser, Laura M; Gray, Joe W; Korkola, James E; Mills, Gordon B; LaBarge, Mark; Feiler, Heidi S; Dane, Mark A; Bucher, Elmar; Nederlof, Michel; Sudar, Damir; Gross, Sean; Kilburn, David F; Smith, Rebecca; Devlin, Kaylyn; Margolis, Ron; Derr, Leslie; Lee, Albert; Pillai, Ajay  (2018). The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell systems, 6 (1) , 13-24More Information

Haber, Lynne T; Reichard, John F; Henning, Alice K; Dawson, Peter; Chinthrajah, R Sharon; Sindher, Sayantani B; Long, Andrew; Vincent, Melissa J; Nadeau, Kari C; Allen, Bruce C  (2021). Bayesian hierarchical evaluation of dose-response for peanut allergy in clinical trial screening. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 151, 112125More Information

Juarez, Paul D; Tabatabai, Mohammad; Valdez, Robert Burciaga; Hood, Darryl B; Im, Wansoo; Mouton, Charles; Colen, Cynthia; Al-Hamdan, Mohammad Z; Matthews-Juarez, Patricia; Lichtveld, Maureen Y; Sarpong, Daniel; Ramesh, Aramandla; Langston, Michael A; Rogers, Gary L; Phillips, Charles A; Reichard, John F; Donneyong, Macarius M; Blot, William  (2020). The Effects of Social, Personal, and Behavioral Risk Factors and PM2.5 on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients. International journal of environmental research and public health, 17 (10) More Information

Ishau, Simileoluwa; Reichard, John F; Maier, Andrew; Niang, Mamadou; Yermakov, Michael; Grinshpun, Sergey A  (2020). Estimated dermal exposure to nebulized pharmaceuticals for a simulated home healthcare worker scenario. Journal of occupational and environmental hygiene, 17 (4) , 193-205More Information

Reichard, J F; Phelps, S E; Lehnhardt, K R; Young, M; Easter, B D  (2023). The effect of long-term spaceflight on drug potency and the risk of medication failure. NPJ microgravity, 9 (1) , 35More Information

Niang, Mamadou; Reichard, John F; Maier, Andrew; Talaska, Glenn; Ying, Jun; Santo Domingo, Jorge; Varughese, Eunice; Boczek, Laura; Huff, Emma; Reponen, Tiina  (2023). Ciprofloxacin- and azithromycin-resistant bacteria in a wastewater treatment plant. Journal of occupational and environmental hygiene, 20 (5-6) , 219-225More Information

Pilarczyk, Marcin; Fazel-Najafabadi, Mehdi; Kouril, Michal; Shamsaei, Behrouz; Vasiliauskas, Juozas; Niu, Wen; Mahi, Naim; Zhang, Lixia; Clark, Nicholas A; Ren, Yan; White, Shana; Karim, Rashid; Xu, Huan; Biesiada, Jacek; Bennett, Mark F; Davidson, Sarah E; Reichard, John F; Roberts, Kurt; Stathias, Vasileios; Koleti, Amar; Vidovic, Dusica; Clarke, Daniel J B; Schürer, Stephan C; Ma'ayan, Avi; Meller, Jarek; Medvedovic, Mario  (2022). Connecting omics signatures and revealing biological mechanisms with iLINCS. Nature communications, 13 (1) , 4678More Information

Niemeier, Richard Todd; Maier, Andrew; Reichard, John F  (2022). Rapid Review of Dermal Penetration and Absorption of Inorganic Lead Compounds for Occupational Risk Assessment. Annals of work exposures and health, 66 (3) , 291-311More Information

El-Khoury, Bashir B; Ray, Kristi L; Altchuler, Steven I; Reichard, John F; Dukes, Charles H  (2023). Selective Serotonin Reuptake Inhibitors and Other Treatment Modalities for Deep Space Missions. Aerospace medicine and human performance, 94 (11) , 843-851More Information

Jolly, Robert A; Bandara, Suren; Bercu, Joel; Callis, Courtney M; Dolan, David G; Graham, Jessica; HaMai, Diem; Barle, Ester Lovsin; Maier, Andrew; Masuda-Herrera, Melisa; Moudgal, Chandrika; Parker, Jillian A; Reichard, John; Sandhu, Reena; Fung, Ernest S  (2022). Setting impurity limits for endogenous substances: Recommendations for a harmonized procedure and an example using fatty acids. Regulatory toxicology and pharmacology : RTP, 134, 105242More Information

Symmank, Judit; Bayer, Cathrin; Reichard, Julia; Pensold, Daniel; Zimmer-Bensch, Geraldine  (2020). Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks. Epigenetics, 15 (11) , 1259-1274More Information

Cifuentes, Patricia; Reichard, John; Im, Wansoo; Smith, Sakima; Colen, Cynthia; Giurgescu, Carmen; Williams, Karen Patricia; Gillespie, Shannon; Juarez, Paul D; Hood, Darryl B  (2019). Application of the Public Health Exposome Framework to Estimate Phenotypes of Resilience in a Model Ohio African-American Women's Cohort. Journal of urban health : bulletin of the New York Academy of Medicine, 96 (Suppl 1) , 57-71More Information

Dourson, Michael L; Higginbotham, Jeri; Crum, Jeff; Burleigh-Flayer, Heather; Nance, Patricia; Forsberg, Norman D; Lafranconi, Mark; Reichard, John  (2017). Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane. Regulatory toxicology and pharmacology : RTP, 88, 45-55More Information

Niang, Mamadou; Reponen, Tiina; Talaska, Glenn; Ying, Jun; Reichard, John F; Pecquet, Alison; Maier, Andrew  (2024). Preliminary human health risk assessment of antibiotic exposures in human waste handling occupations. Journal of occupational and environmental hygiene, 21 (10) , 721-740More Information