William M Ridgway , MD

Bachelor's Degree: Haverford College 1982 (Liberal Arts)

Post-baccalaureate: Bryn Mawr College 1985 (Pre-medical)

Medical Degree: University of Rochester 1989

Residency : Stanford University Hospital 1992 (Internal Medicine)

Clinical Fellowship: Stanford University Hospital 1994 (Rheumatology/Immunology )

Physician Postdoctoral Fellowship : Howard Hughes Medical Institute 1996 (Immunology )

Research Fellowship: Stanford University School of Medicine 1997 (Immunology )

Research Associate : Stanford University School of Medicine 1998 (Immunology )

Internal Medicine

Rheumatology

Autoimmunity, Immunogenetics, T cells, Autoimmune (Type I) Diabetes, Autoimmune Liver Disease (Primary Biliary Cirrhosis), Relapsing polychondritis.

1998 -2003 Chief, Division of Rheumatology, Oakland VA Hospital, Pittsburgh, PA

1998 -2007 Assistant Professor of Medicine, Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA

2007 -2008 Associate Professor of Medicine (tenure), Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA

2009 -To Present Member, Cincinnati Rheumatic Diseases Core Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

2009 -To Present Member, Physician Scientist Training Program, University of Cincinnati School of Medicine, Cincinnati, OH

2009 -To Present Investigator, Digestive Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

2009 -To Present Member, Immunobiology Graduate Faculty, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

2008 -To Present Member, Pathobiology and Molecular Medicine Graduate Faculty, University of Cincinnati School of Medicine, Cincinnati, OH

2008 -To Present Director, Division of Immunology, Allergy and Rheumatology, University of Cincinnati School of Medicine, Cincinnati, OH

2008 -To Present Associate Professor (tenure), Division of Immunology, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, OH

Grant: #RO1 DK074768 2006 -2011 NIH The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis Role:PI $158,076

Grant: #P30 AR47363 2009 -2011 NIH/NIAMS A novel model of relapsing polychronditis in NOD congenic mice Role:PI $50,000

Grant: #U19AI56374 2003 -2009 NIH Immunogenetic Control of NOD CD4+ T cell Tolerance $144,304

Grant: #U19 AI 056362 / SUB 08-B-113 Investigators:Ridgway, William 11-01-2008 -07-31-2009 National Institute of Allergy and Infectious Diseases Immunogenetic Control of NOD CD4+ T cell Tolerance Role:PI $80,097.00 Closed Level:Federal

Grant: #UCD / SUB 5 R01 DK074768 Investigators:Ridgway, William 11-01-2008 -03-31-2011 National Inst of Diabetes and Digestive and Kidney Disease The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis Role:PI $444,917.00 Closed Level:Federal

Grant: #CHMC 103838 / 1 P30 AR047363 Investigators:Ridgway, William 07-01-2009 -06-30-2011 National Institute of Arthritis, Musculoskeletal and Skin Disease A Novel Model of Relapsing Polychondritis in NOD Congenic Mice Role:PI $157,000.00 Closed Level:Federal

Grant: #K23 HL094532 Investigators:Kinder, Brent; McCormack, Francis; Ridgway, William; Shukla, Rakesh 02-01-2010 -01-31-2015 National Heart, Lung and Blood Institute Undifferentiated Corrective Tissue-Associated Interstital Role:Collaborator $285,772.00 Closed Level:Federal

Grant: #201013238-01 / R01 DK090019 Investigators:Ridgway, William 09-30-2010 -06-30-2014 National Inst of Diabetes and Digestive and Kidney Disease dnTGF Beta RII Mice and Primary Biliary Cirrhosis (PBC) Role:PI $665,094.00 Active Level:Federal

Grant: #105886 / DK084054 Investigators:Ridgway, William 06-01-2010 -05-31-2014 National Inst of Diabetes and Digestive and Kidney Disease Primary Biliary Cirrhosis: Molecular Genetics and Microbial Pathogenesis Role:PI $29,157.00 Active Level:Federal

Grant: #1-11-BS-131 Investigators:Ridgway, William 01-01-2011 -12-31-2013 American Diabetes Association Soluble CD137 in Type One Diabetes Role:PI $327,750.00 Active Level:Private Non-Profit

Grant: #201400949-01 / R01 DK090019 Investigators:Ridgway, William 08-11-2014 -06-30-2018 National Inst of Diabetes and Digestive and Kidney Disease dnTGF Beta RII Mice and PBC Role:PI $230,976.00 Active Level:Federal

Grant: #R21 AI120084 Investigators:Ridgway, William 06-15-2015 -05-31-2017 National Institute of Allergy and Infectious Diseases Mechanism of restored immune tolerance in anti-TLR4 antibody reversal of NOD T1D Role:PI $237,063.00 Awarded Level:Federal

Grant: #WSU sub / R56 DK103651 Investigators:Ridgway, William 09-01-2015 -08-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Design Molecular Vaccines for Type 1 Diabetes Role:PI $49,577.00 Active Level:Federal

Grant: #MCW_ADA 1-16-IBS-049 Investigators:Ridgway, William 01-01-2016 -12-31-2018 American Diabetes Association Mechanistic role and therapeutic potential of CD137 in T1D Role:PI $51,700.00 Active Level:Private Non-Profit

Grant: #Med College of Wisconsin sub R01DK107541 Investigators:Ridgway, William 07-21-2016 -05-31-2017 National Inst of Diabetes and Digestive and Kidney Disease Mechanistic and therapeutic role of the CD137-CD137L axis in Type 1 Diabetes Role:PI $253,461.00 Active Level:Federal

Grant: #U01DA048525 Investigators:Dasenbrock-Gamm, Hanna; Kirley, Terence; Nelson, Erik; Norman, Andrew; Ridgway, William; Webster, Rose; Welge, Jeffrey 07-01-2019 -04-30-2022 National Institute on Drug Abuse First-In-Human Study of a Humanized Anti-Cocaine Monoclonal Antibody Role:Collaborator $4,770,702.00 Awarded Level:Federal

Peer Reviewed Publications

Huang, Wenting; Kachapati, Kritika; Adams, David; Wu, Yuehong; Leung, Patrick S C; Yang, Guo-Xiang; Zhang, Weici; Ansari, Aftab A; Flavell, Richard A; Gershwin, M Eric; Ridgway, William M (2014. ) Murine autoimmune cholangitis requires two hits: Cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.Journal of autoimmunity, , More Information

Ridgway, William M (2014. ) A new tool for dissecting genetic control of type 1 diabetes.Diabetes, , 63 (1 ) ,56-8 More Information

Kachapati, Kritika; Bednar, Kyle J; Adams, David E; Wu, Yuehong; Mittler, Robert S; Jordan, Michael B; Hinerman, Jennifer M; Herr, Andrew B; Ridgway, William M (2013. ) Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice.Journal of autoimmunity, , 47 ,94-103 More Information

Kachapati, Kritika; Adams, David E; Wu, Yuehong; Steward, Charles A; Rainbow, Daniel B; Wicker, Linda S; Mittler, Robert S; Ridgway, William M (2012. ) The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.Journal of immunology (Baltimore, Md. : 1950), , 189 (10 ) ,5001-15 More Information

Kachapati, Kritika; Adams, David; Bednar, Kyle; Ridgway, William M (2012. ) The non-obese diabetic (NOD) mouse as a model of human type 1 diabetes.Methods in molecular biology (Clifton, N.J.), , 933 ,3-16 More Information

Mohammed, Javid P; Fusakio, Michael E; Rainbow, Daniel B; Moule, Carolyn; Fraser, Heather I; Clark, Jan; Todd, John A; Peterson, Laurence B; Savage, Paul B; Wills-Karp, Marsha; Ridgway, William M; Wicker, Linda S; Mattner, Jochen (2011. ) Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.Journal of immunology (Baltimore, Md. : 1950), , 187 (1 ) ,337-49 More Information

Bednar, Kyle J; Tsukamoto, Hiroki; Kachapati, Kritika; Ohta, Shoichiro; Wu, Yuehong; Katz, Jonathan D; Ascherman, Dana P; Ridgway, William M (2015. ) Reversal of New-Onset Type 1 Diabetes with an agonistic TLR4/MD-2 Monoclonal Antibody.Diabetes, , More Information

Wang, Yin-Hu; Yang, Wei; Yang, Jing-Bo; Jia, Yan-Jie; Tang, Wei; Gershwin, M Eric; Ridgway, William M; Lian, Zhe-Xiong (2015. ) Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis.Journal of autoimmunity, , 59 ,26-37 More Information

Ridgway, William M; Gershwin, M Eric (2014. ) Prometheus unbound: NKT cells inhibit hepatic regeneration.Hepatology (Baltimore, Md.), , 60 (4 ) ,1133-5 More Information

Wang, Jinjun; Yang, Guo-Xiang; Tsuneyama, Koichi; Gershwin, M Eric; Ridgway, William M; Leung, Patrick S C (2014. ) Animal models of primary biliary cirrhosis.Seminars in liver disease, , 34 (3 ) ,285-96 More Information

Bednar, Kyle J; Ridgway, William M (2014. ) Targeting innate immunity for treatment of type 1 diabetes.Immunotherapy, , 6 (12 ) ,1239-42 More Information

Yang, Wei; Yao, Yuan; Yang, Yan-Qing; Lu, Fang-Ting; Li, Liang; Wang, Yin-Hu; Nakajima, Takahiko; Tsuneyama, Koichi; Ridgway, William M; Gershwin, M Eric; Lian, Zhe-Xiong (2014. ) Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2R? deleted mice.PloS one, , 9 (8 ) ,e105351 More Information

Itoh, Arata; Ridgway, William M (2017. ) Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes.ImmunoTargets and therapy, , 6 ,31-38 More Information

Forsberg, Matthew H; Ciecko, Ashley E; Bednar, Kyle J; Itoh, Arata; Kachapati, Kritika; Ridgway, William M; Chen, Yi-Guang (2017. ) CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice.Journal of immunology (Baltimore, Md. : 1950), , 198 (10 ) ,3857-3868 More Information

Ma, Hong-Di; Ma, Wen-Tao; Liu, Qing-Zhi; Zhao, Zhi-Bin; Liu, Mu-Zi-Ying; Tsuneyama, Koichi; Gao, Jin-Ming; Ridgway, William M; Ansari, Aftab A; Gershwin, M Eric; Fei, Yun-Yun; Lian, Zhe-Xiong (2017. ) Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8(+) T cell activation.Journal of autoimmunity, , 78 ,19-28 More Information

Yang, G-X; Sun, Y; Tsuneyama, K; Zhang, W; Leung, P S C; He, X-S; Ansari, A A; Bowlus, C; Ridgway, W M; Gershwin, M E (2016. ) Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice.Clinical and experimental immunology, , 185 (2 ) ,154-64 More Information

Yang, Jing-Bo; Wang, Yin-Hu; Yang, Wei; Lu, Fang-Ting; Ma, Hong-Di; Zhao, Zhi-Bin; Jia, Yan-Jie; Tang, Wei; Tsuneyama, Koichi; Ridgway, William M; Gershwin, M Eric; Lian, Zhe-Xiong (2016. ) Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.Journal of autoimmunity, , 66 ,108-17 More Information

1982 Phi Beta Kappa

1982 Magna cum Laude Departmental High Honors, Departmental First Prize

1989 Alpha Omega Alpha

1999 Pfizer Faculty Scholar Immunology/Rheumatology

1999 Juvenile Diabetes Foundation International Career Development Award

1999 Co-award: H.M. Margolis Research Grant

Immunology, Rheumatology

Academic - Health Professions Building
3255 Eden Ave
Cincinnati  Ohio, 45267-0563
Phone: 513-558-4701
Fax: 513-558-3799
william.ridgway@uc.edu