Nathan James Robbins

Personal Statement
People describe me as optimistic, happy and jolly; the one with the laugh you can hear down the hall. More than anything, I think optimism is the key feature that has gotten me to the point of fulfilling my dream of becoming a physician. Optimism has helped me keep a clear mind while trying to care for severely ill patients, it has kept me going through the last miles of marathons and has been a light for me to follow as I worked my way through manuscripts and grant revisions. 
 
Why I Chose Cincinnati
Cincinnati is home. In addition to being born and raised in Cincinnati, UC is the place where I fell in love with medicine. While doing research to prepare myself for medical school, I was able to observe how medicine was practiced, how clinical and basic science research can impact patient care and how I can contribute to the advancement of medical knowledge. The PSTP program at UC will allow me to become the clinician and scientist I aspire to be.

Master of Science: University of Cincinnati Cincinnati, OH, 2012

Bachelor of Science: University of Cincinnati Cincinnati, OH, 2011

DO: Ohio University Heritage College of Osteopathic Medicine

Cardiovascular Disease; Mechanisms underlying Heart Failure progression; Cardiac function; Translational Research; Clinical Trials; Basic Science; Echocardiography; Drug Development

Peer Reviewed Publications

Lam CK, Zhao W, Cai W, Vafiadaki E, Florea SM, Ren X, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, and Kranias EG  (2013). Novel Role of HAX-1 in Ischemic Injury Protection: Involvement of Hsp90. Circulation Research, 112 (1) , 79

Rubinstein, Jack; Robbins, Nathan; Evans, Karen; Foster, Gabrielle; Mcconeghy, Kevin; Onadeko, Toluwalope; Bunke, Julie; Parent, Melanie; Luo, Xi; Joseph, Jacob; Wu, Wen-Chih  (2022). Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial. Trials, 23 (1) , 266More Information

Kirschner, Akiva; Koch, Sheryl E; Robbins, Nathan; Karthik, Felix; Mudigonda, Parvathi; Ramasubramanian, Ranjani; Nieman, Michelle L; Lorenz, John N; Rubinstein, Jack  (2021). Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response. Cardiovascular toxicology, 21 (11) , 889-900More Information

Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang  (2021). Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages. Cardiovascular research, 117 (3) , 890-902More Information

O'Connor, Brian; Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack  (2021). TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies. Progress in biophysics and molecular biology, 159, 118-125More Information

Horimatsu, Tetsuo; Blomkalns, Andra L; Ogbi, Mourad; Moses, Mary; Kim, David; Patel, Sagar; Gilreath, Nicole; Reid, Lauren; Benson, Tyler W; Pye, Jonathan; Ahmadieh, Samah; Thompson, Allie; Robbins, Nathan; Mann, Adrien; Edgell, Ashlee; Benjamin, Stephanie; Stansfield, Brian K; Huo, Yuqing; Fulton, David J; Agarwal, Gautam; Singh, Nagendra; Offermanns, Stefan; Weintraub, Neal L; Kim, Ha Won  (2020). Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Cardiovascular research, 116 (14) , 2226-2238More Information

Onusko, Evan; McDermott, Michael R; Robbins, Nathan; Liu, Guansheng; Kranias, Evangelia G; Rubinstein, Jack; Koch, Sheryl E  (2020). Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. PloS one, 15 (3) , e0230386More Information

Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G  (2019). Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC. Basic to translational science, 4 (2) , 188-199More Information

Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael  (2019). Human antigen R as a therapeutic target in pathological cardiac hypertrophy. JCI insight, 4 (4) More Information

Robbins, Nathan; Hooker, Edmond A; Hart, Kim W; Kapur, Sangita; Blomkalns, Andra  (2019). Computed tomographic quantification of periaortic adipose tissue volume as a correlate of cardiovascular disease. Cardiology journal, 26 (6) , 802-804More Information

Owens, A Phillip; Robbins, Nathan; Saum, Keith; Jones, Shannon M; Kirschner, Akiva; Woo, Jessica G; McCoy, Connie; Slone, Samuel; Rothenberg, Marc E; Urbina, Elaine M; Tranter, Michael; Rubinstein, Jack  (2018). Tefillin use induces remote ischemic preconditioning pathways in healthy men. American journal of physiology. Heart and circulatory physiology, 315 (6) , H1748-H1758More Information

Liu, Guan-Sheng; Gardner, George; Adly, George; Jiang, Min; Cai, Wen-Feng; Lam, Chi Keung; Alogaili, Fawzi; Robbins, Nathan; Rubinstein, Jack; Kranias, Evangelia G  (2018). A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of cellular and molecular medicine, 22 (8) , 3911-3919More Information

Daly, Patrick; Kayse, Regina; Rudick, Steven; Robbins, Nathan; Scheler, Jennifer; Harris, David; O'Donnell, Robert; Dwivedi, Alok K; Gerson, Myron C  (2018). Feasibility and safety of exercise stress testing using an anti-gravity treadmill with Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) myocardial perfusion imaging: A pilot non-randomized controlled study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 25 (4) , 1092-1097More Information

Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack  (2018). Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels. Journal of cardiovascular pharmacology, 72 (1) , 40-48More Information

Jones, Shannon M; Mann, Adrien; Conrad, Kelsey; Saum, Keith; Hall, David E; McKinney, Lisa M; Robbins, Nathan; Thompson, Joel; Peairs, Abigail D; Camerer, Eric; Rayner, Katey J; Tranter, Michael; Mackman, Nigel; Owens, A Phillip  (2018). PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 (6) , 1271-1282More Information

Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack  (2018). Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 (2) More Information

Jones, Shannon; Mann, Adrien; Worley, Mariah C; Fulford, Logan; Hall, David; Karani, Rajiv; Jiang, Min; Robbins, Nathan; Rubinstein, Jack; Koch, Sheryl E  (2017). The role of transient receptor potential vanilloid 2 channel in cardiac aging. Aging clinical and experimental research, 29 (5) , 863-873More Information

Koch, Sheryl E; Mann, Adrien; Jones, Shannon; Robbins, Nathan; Alkhattabi, Abdullah; Worley, Mariah C; Gao, Xu; Lasko-Roiniotis, Valerie M; Karani, Rajiv; Fulford, Logan; Jiang, Min; Nieman, Michelle; Lorenz, John N; Rubinstein, Jack  (2017). Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. Journal of hypertension, 35 (3) , 602-611More Information

Naticchioni, Mindi; Karani, Rajiv; Smith, Margaret A; Onusko, Evan; Robbins, Nathan; Jiang, Min; Radzyukevich, Tatiana; Fulford, Logan; Gao, Xu; Apel, Ryan; Heiny, Judith; Rubinstein, Jack; Koch, Sheryl E  (2015). Transient Receptor Potential Vanilloid 2 Regulates Myocardial Response to Exercise. PloS one, 10 (9) , e0136901More Information

Mann, Adrien; Thompson, Allie; Robbins, Nathan; Blomkalns, Andra L  (2014). Localization, identification, and excision of murine adipose depots. Journal of visualized experiments : JoVE (94) More Information

Robbins, Nathan; Thompson, Allie; Mann, Adrien; Blomkalns, Andra L  (2014). Isolation and excision of murine aorta; a versatile technique in the study of cardiovascular disease. Journal of visualized experiments : JoVE (93) , e52172More Information

Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N  (2014). Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American journal of physiology. Heart and circulatory physiology, 306 (4) , H574-84More Information

Basford, Joshua E; Koch, Sheryl; Anjak, Ahmad; Singh, Vivek P; Krause, Eric G; Robbins, Nathan; Weintraub, Neal L; Hui, David Y; Rubinstein, Jack  (2013). Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PloS one, 8 (11) , e82026More Information

Koch, Sheryl E; Haworth, Kevin J; Robbins, Nathan; Smith, Margaret A; Lather, Navneet; Anjak, Ahmad; Jiang, Min; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack  (2013). Age- and gender-related changes in ventricular performance in wild-type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging: a retrospective study. Ultrasound in medicine & biology, 39 (11) , 2034-43More Information

Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack  (2013). Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Translational research : the journal of laboratory and clinical medicine, 161 (6) , 469-76More Information

Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack  (2013). Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. Journal of cardiovascular pharmacology and therapeutics, 18 (3) , 280-9More Information

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack  (2012). Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 (1) , 134-44More Information

Gupta, Nishant; Zhang, Bin; Zhou, Yuan; McCormack, Francis X; Ingledue, Rebecca; Robbins, Nathan; Kopras, Elizabeth J; McMahan, Susan; Singla, Abhishek; Swigris, Jeffrey; Cole, Adam G; Holz, Marina K  (2023). Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. Chest, 163 (5) , 1144-1155More Information

Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack  (2012). The history and future of probenecid. Cardiovascular toxicology, 12 (1) , 1-9More Information

Lam, Chi Keung; Zhao, Wen; Cai, Wenfeng; Vafiadaki, Elizabeth; Florea, Stela M; Ren, Xiaoping; Liu, Yong; Robbins, Nathan; Zhang, Zhiguo; Zhou, Xiaoyang; Jiang, Min; Rubinstein, Jack; Jones, W Keith; Kranias, Evangelia G  (2013). Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation research, 112 (1) , 79-89More Information

Academic - Medical Science Building
231 Albert Sabin Way, MLC 0542
Cincinnati  Ohio, 45627
Phone: 513-558-0237
Nathan.Robbins@uc.edu