Ashley Ross

Ashley Elizabeth Ross

Assoc Professor

Rieveschl Hall

418A

A&S Chemistry - 0172

Professional Summary

Ashley Ross is an Associate Professor in the Department of Chemistry. She is a bioanalytical chemist with expertise in electrochemistry, microfluidics, neurochemistry, and ex vivo experimentation. After obtaining her B.S. in Chemistry at Christopher Newport University in 2009, she went on to receive her Ph.D. in Analytical Chemistry at the University of Virginia under Dr. Jill Venton in 2014. During her PhD, she focused on developing electrochemical methods to detect rapid adenosine changes in the brain. She worked as a post-doctoral scholar under Dr. Rebecca Pompano at the University of Virginia from 2014 until 2017 developing microfluidic methods to study local stimulation and diffusion within the lymph node. There she was awarded the American Association of Immunologists Careers in Immunology Fellowship for her work focused on developing methods to probe brain-immune interactions. She joined the University of Cincinnati faculty in 2017, with research interests focused on developing methods to probe brain-immune communications and methods for quantifying neurotransmitter signaling between the brain and immune system. Snice 2017, her work has been recognized by an NSF CAREER Award, the Alfred P. Sloan Fellowship, and the RCSA Microbiome, Neurobiology, and Disease Fellow Awards. In addition, she has been awarded two NIH R01's to study the mechanism of neurochemical signaling in the lymph node and to develop methods to study guanosine signaling during brain ischemia. 

Please visit www.rosslabuc.com for more information
Twitter Handle: @RossLabUC

Education

Ph.D. Analytical Chemistry : University of Virginia 2014

B.S. Chemistry: Christopher Newport University 2009

Research and Practice Interests

The Ross lab is interested in:
(1) Developing electrochemical methods to study neurotransmitter signaling in the brain and immune system
(2) Synthesizing and characterizing new carbon materials for electrochemical detection
(3) Develop microfluidic platforms for probing brain and brain-immune interactions

Research Support

Grant: #R01AI151552 Investigators:Ross, Ashley (PI); Steve Davidson 09-14-2020 -08-31-2025 NIH National Institute of Allergy and Infectious Diseases "Monitoring neurochemical signaling dynamics in the lymph node" Role:PI $1,931,010 Active Type:Grant Level:National

Grant: #R01NS121426 Investigators:Ross, Ashley (PI) 02-01-2021 -01-31-2026 NIH NINDS Monitoring rapid guanosine signaling during ischemia Role:PI $1,906,984 Active Type:Grant

Grant: #R01NS121426 Investigators:Ross, Ashley 02-01-2021 -01-31-2026 National Institute of Neurological Disorders and Stroke Monitoring rapid guanosine signaling during ischemia Role:PI $372,176.00 Active Type:Grant

Investigators:Ross, Ashley 07-01-2021 -06-30-2022 Research Corporation for Science Advancement Award #27935 - Engineering enteric neuron activity to enhance antimicrobial immunity in the gut Role:PI 0.00 Active

Grant: #2143520 Investigators:Ross, Ashley 01-01-2022 -12-31-2026 National Science Foundation CAREER: Tunable graphene microelectrodes for real-time biological sensing Role:PI 300000.00 Active

Grant: #Alfred P. Sloan Research Fellow Investigators:Ross, Ashley 09-15-2022 -09-14-2024 Alfred P. Sloan Foundation Expanding the analytical toolbox to study neuroimmune communication - Ross Sloan Fellowship Role:PI 0.00 Awarded Level:Non Profit

Grant: #28651 Investigators:Ross, Ashley 07-15-2022 -07-14-2023 Research Corporation for Science Advancement Unraveling the effect and mechanism of enteric microbiota-neuron communication in aging Role:PI 55000.00 Hold Level:Non Profit

Abbreviated Publications

Peer Reviewed Publications

A.E. Ross, M. Belanger, J. Woodroof, R.R. Pompano (2017). Spatially resolved microfluidic stimulation of lymphoid tissue ex vivo. Analyst, 142, 649-659.

M.D. Nguyen, A.E. Ross, M. Ryals, S.T. Lee, & B.J. Venton (2015). Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacology and Research Perspectives, 3(6).

A.E. Ross & B.J. Venton (2015). Adenosine transiently modulates dopamine by A1 receptors in the caudate putamen. Journal of Neurochemistry, 132(1), 51-60.

A.G. Zestos, C.B. Jacobs, E. Trikantzopoulos, A.E. Ross, & B.J. Venton (2014). Polyethylenimine carbon nanotube fiber electrodes for enhanced detection of neurotransmitters. Analytical Chemistry, 86(17), 8568-8575.

A.E. Ross & B.J. Venton (2014). Sawhorse waveform voltammetry for selective detection of adenosine, ATP, and hydrogen peroxide. Analytical Chemistry, 86(15), 7486-7493.

A.E. Ross, M.D. Nguyen, E. Privman, & B.J. Venton (2014). Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex. Journal of Neurochemistry, 130(1), 50-60.

M.D. Nguyen, S.T. Lee, A.E. Ross, M. Ryals, V.I. Chaudhry, & B.J. Venton (2014). Characterization of spontaneous, transient adenosine release the caudate-putamen and prefrontal cortex. PLOS one, 9(1).

H. Fang, M.L. Pajski, A.E. Ross, B.J. Venton (2013). Quantitation of dopamine, serotonin, and adenosine in a single brain slice using capillary electrophoresis with fast-scan cyclic voltammetry. Analytical Methods, 5, 2704-2711.

A.E. Ross & B.J. Venton (2012). Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine. Analyst, 137(13), 3045-3051.

M.J. Peairs*, A.E. Ross*, & B.J. Venton (2011). Comparison of Nafion- and overoxidized polypyrrole carbon-nanotube electrodes for neurotransmitter detection. Analytical Methods, 3, 2379-2386.

A.L. Hensley, A.Colley, and A.E. Ross (2018). Real-time detection of melatonin using fast-scan cyclic voltammetry. Anal Chem. 90 (14), 8642-8650.

M.T. Cryan and A.E.Ross (2018). Subsecond detection of guanosine using fast-scan cyclic voltammetry. Analyst (Emerging Investigator Series).

G.N. Lim and A.E. Ross. Purine functional group type and placement modulate the interaction at carbon-fiber microelectrodes. ACS Sens., 2019, 4(2), 479-487

M.E. Weese*, R.A. Krevh*, Y.Li, N.T. Alvarez, A.E. Ross. Defect sites modulate fouling resistance on carbon-nanotube fiber electrodes. ACS Sens. 2019, 4 (4), pp 1001–1007

*undergraduate researchers

M.T. Cryan and A.E. Ross. Scalene waveform for co-detection of guanosine and adenosine with fast-scan cyclic voltammetry. Anal. Chem. 2019, 91(9), 5987-5993.

M.C. Belanger, A.W.L. Kinman, M.A. Catterton, A.G. Ball, B.D. Groff, S.J. Melchor. J.R. Luckens, A.E. Ross and R.R. Pompano. Acute lymph node slices are a functional model system to study immunity ex vivo. Just Accepted to ACS Pharmacology & Translational Science, 2020.

S.L. Regan, M.T. Cryan, M. Williams, C.V. Vorhees, and A.E. Ross. Enhanced transient striatal dopamine release and reuptake in Lphn3 KO rats. ACS Chemical Neuroscience, 2020, 11(8), 1171-1177. https://doi.org/10.1021/acschemneuro.0c00033

Y.Li, C.M. Fleischer*, A.E. Ross. High Young’s modulus carbon fibers are fouling resistant with fast-scan cyclic voltammetry. Chem. Commun. 2020, 56, 8023 – 8026. (invited publication, ChemComm Emerging Investigators Issue 2020 and selected for Back Cover). 10.1039/d0cc02517h

G.N. Lim and A.E. Ross. Subsecond spontaneous catecholamine release in mesenteric lymph node ex vivo. Journal of Neurochemistry, 2020, 155(4), 417-429.  10.1111/jnc.15115

Yuxin Li and A.E. Ross. Amine-functionalized carbon-fiber microelectrodes for enhanced ATP detection with fast-scan cyclic voltammetry. Analytical Methods, 2021, 13, 2320-2330

A. Perry, M.T. Cryan, and A.E. Ross. Extended sawhorse waveform for stable zinc detection with fast-scan cyclic voltammetry. Analytical Bioanalytical Chemistry, 2021, 413(27), 6727-6735. (Electrochemistry for Neurochemical Analysis themed collection)

M.E. Weese-Myers and A.E. Ross. Characterization of electroactive amino acids with fast-scan cyclic voltammetry. J. Electrochem. Soc. (SEAC Themed Collection), 2021, 168, 126524.  https://doi.org/10.1149/1945-7111/ac4187

Book Chapter

A.E. Ross & B.J. Venton (2014). Electrochemical detection of adenosine in vivo. In G.S. Wilson and A.C. Michael (Eds.), Advances in real-time molecular neuroscience. Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience Singapore: World Scientific Publishing Co.

Invited Publication

A.E. Ross & R.R. Pompano (2017). Diffusion of cytokines in live lymph node tissue using microfluidic integrated optical imaging. Analytica Chemica Acta, 1000, 205-213.

A.E. Ross. Plasma-treated carbon-fiber microelectrodes for improved purine detection with fast-scan cyclic voltammetry. Just Accepted, Analyst, Invited Publication

L.M. Delong, Y.Li, G.N. Lim, S.G. Wairegi*, and A.E. Ross. A microfluidic electrochemical flow cell capable of rapid on-chip analyte dilution for fast-scan cyclic voltammetry calibration. Anal. Bioanal. Chem. 2020, 412 (24), 6287-6294

 Y. Li, A.L. Keller, M.T. Cryan, and A.E. Ross. Metal nanoparticle modified carbon-fiber microelectrodes enhance ATP surface interactions with fast-scan cyclic voltammetry. Just Accepted. ACS Measurement Science Au (invited), 2021

A.J. Syeed*, ϯ, Y.Li ϯ, B.J. Ostertag, J.W. Brown*, and A.E. Ross. Nanostructured carbon-fiber surfaces for improved neurochemical detection. Just Accepted. Faraday Discussions, 2021. DOI: 10.1039/D1FD00049G
ϯCo-first authors

Presentations

Invited Presentations

A.E. Ross and R.R. Pompano (05-14-2015. ) Spatially discrete targeting of lymph node slices on a microfluidic chip .Annual Post-Doctoral Symposium , University of Virginia . Level:University

A.E. Ross and R.R. Pompano (08-23-2017. ) Transport analysis of cytokines in live lymph node tissue on-chip .ACS National Meeting , Washington DC. Conference. . Level:National

A.E Ross (11-10-2017. ) Spatially and temporally resolved electrochemical detection of brain-immune interactions on-chip .Huntington University, Huntington, IN. Other Institution. . Level:University

A.E. Ross (09-06-2017. ) Rapid neurochemical sensing within the brain-immune system .Neuroscience Program Seminar Series , Cincinnati, OH. UC. . Level:University

A.E. Ross (01-05-2018. ) Rapid electrochemical sensing in the brain .UC Annual Sensors Retreat, UC . UC. . Level:Regional

A.E. Ross (09-14-2018. ) Unraveling the mechanism of melatonin signaling in the immune system using fast-scan cyclic voltammetry .Wright State University, Other Institution. . Level:University

A.E. Ross (2019. ) Real-time detection of neuroimmune communication .University of Cincinnati, University of Bordeaux Talk . UC. . Level:Department

A.E. Ross (2019. ) Subsecond detection of neuroimmune communication in the lymph node .University of Cincinnati, Oesper Symposium. UC. . Level:Regional

A.E. Ross Improving FSCV detection: Novel carbon surfaces and microfluidic platforms for controlled detection .Pittcon , Chicago. Conference. . Level:National

A.E. Ross Conference. .

A.E. Ross

A.E. Ross Novel carbon surfaces for real-time neurochemical detection .Virtual, Conference. . Level:National

A.E. Ross New analytical approaches to probe communication between the gut and the brain .Virtual , American University. Other Institution. .

A.E. Ross Using electrochemistry to measure signaling along the gut-brain axis .Virtual, University of Iowa. Other Institution. .

A.E. Ross New analytical approaches to probe communication between the gut and the brain .Virtual, George Mason University. Other Institution. .

A.E. Ross Developing tools to measure neuro-immune communication .Virtual, University of Arkansas. Other Institution. .

A.E. Ross Developing tools to measure dynamic guanosine signaling during focal ischemia .Brigham Young University, Dept. of Physiology and Developmental Biology. Other Institution. . Level:University

A.E. Ross Combining electrochemistry and microfluidics to study neuro-immune communication .University of Illinois Chicago, Dept. of Chemistry. Other Institution. . Level:University

A.E. Ross Investigations of the purine-electrode interface with fast-scan cyclic voltammetry .The Electrochemical Society Spring Meeting (Invited to the Advances in Organic and Biological Electrochemistry Symposium in honor of Dennis Peters. Conference. . Level:International

A.E. Ross Analytical approaches to detect neuroimmune signaling .ACS National Meeting Fall 2021. Level:National

A.E. Ross New analytical approaches to measure brain-immune communication .Cleveland State University, Department of Chemistry. Other Institution. . Level:University

A.E. Ross New analytical methods to stimulate and detect brain-immune communication .Wayne State University, Department of Chemistry. Other Institution. . Level:University

A.E. Ross New analytical approaches to measure brain-immune communication .University of Illinois Urbana Champaign, Department of Chemistry. Other Institution. . Level:University

A.E. Ross New analytical approaches to measure brain-immune communication .Tufts University, Department of Chemistry. Other Institution. . Level:University

A.E. Ross New analytical approaches to measure brain-immune communication .University of Michigan, Department of Chemistry. Other Institution. . Level:University

A.E. Ross New analytical approaches to measure brain-immune communication .Case Western Reserve University, Department of Chemical and Biomolecular Engineering. Other Institution. . Level:University

A.E. Ross Sensor Integration for Microsystems” workshop .MicoTAS 2021, Conference. . Level:International

A.E. Ross Nanostructured carbon fibers for enhanced neurochemical detection .Faraday Discussions on “Next Generation Nano-Electrochemstry”. Conference. . Level:International

Poster Presentations

A. Hensley, A. Colley, and A.E. Ross (03-2018. ) Rapid electrochemical monitoring in the immune system .PITTCON , Orlando, FL . . Conference. . Level:National

M.T. Cyran and A.E. Ross (04-2018. ) Subsecond guanosine detection in the brain using fast-scan cyclic voltammetry .UC Gardner Neuroscience Institute/Neuroscience Research Center, UC Children's Hospital. . UC. . Level:University

M.T. Cyran and A.E. Ross (08-2018. ) Optimizing subsecond guanosine detection using fast-scan cyclic voltammetry. .ACS National Meeting, Boston, MA. . Conference. . Level:National

Lecture

A.E. Ross Electrochemistry in Analytical chemistry .University of Illinois Chicago, Dept. of Chemistry. Other Institution. Level:Department

Paper Presentations

A.E. Ross (08-2018. ) Detection of melatonin dynamics in the immune system using fast-scan cyclic voltammetry .Boston, MA. Conference. Level:National

A.E. Ross (11-2018. ) Analytical tools to investigate neurotransmitter regulated immunity .MUACC at MSU . Conference. Level:Regional

A.E. Ross (2019. ) Microengineered platforms to monitor gut-immune communication .Indianapolis, IN. Conference. Level:National

A.E. Ross (2019. ) Subsecond monitoring of neurotransmitters in the lymph node .Philadelphia, PA. Conference. Level:National

Event Organized

Oesper Symposium for Mark Wightman

Oesper Symposium for Mark Wightman Symposium 09-26-2019 09-27-2019 Cincinnati, OH Level:Regional

AC/DC Virtual Seminar Series

AC/DC Virtual Seminar Series Symposium Virtual Level:International

Honors and Awards

08-01-2016 -07-01-2017 Modelling neuroimmune communication on a microfluidic chip American Association of Immunologists Status:Recipient Level:National Type:Fellowship

07-01-2016 -08-31-2016 New Horizons Travel Grant

03-01-2014 -03-31-2014 Robert J. Huskey Travel Fellowship

03-25-2013 -03-25-2013 13th Annual Huskey Graduate School Research Exhibition 3rd place poster

03-01-2012 -03-31-2012 Robert J. Huskey Travel Fellowhip

-2009 Christopher Newport University Chemistry Departmental Honor Award

-2009 ACS Division of Environmental Chemistry Undergraduate Award

-2009 NASA Group Acheivement Award for Surface Ozone Protocol for the GLOBE Project

2018 Faculty Development Funds for Travel University of Cincinnati Status:Recipient Level:University Type:Monetary

2019 Faculty Development Funds for GRC Electrochem

2019 MUACC James W. & Caroline L. Taylor/Division of Analytical Chemistry ACS Travel Funds

Analyst Emerging Investigator

RCSA Scialog: Microbiome, Neurobiology, and Disease Fellow https://rescorp.org/news/2020/03/scialog-microbiome-neurobiology-and-disease-fellows-named Status:Recipient Level:National

Bioanalysis Zone Rising Star, Finalist Status:Nomination Level:International

ChemComm Emerging Investigator Status:Recipient

Office of Research First-Time Sponsored Research Awardee University of Cincinnati Status:Recipient Level:University Type:Recognition

Student Advising

Austin Hensley (Undergrad ) Advisor Status:In Progress

Service

Analytica Chemica Acta Peer Review/Referee Type:Other 2014 -To Present

Journal of Neurochemistry Peer Review/Referee Type:Other

ACS Analytical Chemistry Peer Review/Referee Type:Other

ACS Chemical Neuroscience Peer Review/Referee Type:Other

RSC Analytical Methods Peer Review/Referee Type:Other

RSC Analyst Peer Review/Referee Type:Other

UC Undergraduate Scholarly Showcase Judge Type:Other Educational Service

Neuroscience Research Day Reviewer Type:Other Educational Service

ACS Analytical Chemistry (Features Panel ) Editorial Board Member Type:Service to Professional Associations 01-2019 -12-2021

ACS National Meeting (Advances in Electrochemistry Session ) Co-Chair Type:Service to Professional Associations

Chemistry (Headship Committee ) Committee Member Type:Departmental Service Level:Department

Chemistry (Organized Summer Research Program ) Type:Departmental Service Level:Department

Chemistry (Graduate Admissions ) Committee Member Type:Departmental Service Level:Department

Indian Hill Primary School (Outreach events for 2 days ) Type:Community Service Level:Local

Fairview-Clifton outreach event Type:Community Service Level:Local

University of Cincinnati (Oesper Symposium Organizer ) Other Type:Departmental Service Level:Department 2019

University of Cincinnati (Graduate Admissions Committee ) Member Type:Departmental Service Level:Department

UC Chemistry Department (Graduate Recruitment Weekend Organizer ) Type:Departmental Service Level:Department

UC Chemistry Department (Bioanalytical Search Committee ) Committee Member Type:Departmental Service Level:Department 2019

University of Cincinnati (Aspire IChange Team, Diversity in STEM ) Committee Member Type:University/College Service Level:University 2019

UC Chemistry Department (Equity and Inclusion Task Force ) Member Type:Departmental Service Level:Department

JACS Peer Review/Referee Type:Other

Electrochemical Society Journal Peer Review/Referee Type:Other

Cincinnati Downtown Library (Community Educational Outreach ) Program Coordinator Type:Other Educational Service Level:Local

NIH (CMT Study Section ) Reviewer Type:Grant Panel

Society of Electroanalytical Chemistry Board Member Type:Other Level:National

Diversity, Equity, and Inclusion in Analytical Chemistry Slack Executive Board Type:Other Level:International

Analytical Bioanalytical Chemistry Guest Co-Editor Type:Editorial Service

University of Cincinnati (Chair Faculty Search Committee ) Committee Chair Type:Departmental Service Level:Department

University of Cincinnati (• Early career panel member for faculty orientation ) Other Type:University/College Service Level:University

(• UC Women in Science and Engineering (WISE) mentor ) Mentor Type:University/College Service Level:University

University of Cincinnati (• Search committee member-VAP/Teaching Post doc ) Committee Member Type:Departmental Service Level:Department

(• Diversity, Equity, and Inclusion (DEI) in Research Advisory Council Member ) Committee Member Type:University/College Service Level:University

University of Cincinnati (Doctoral Committee Member ) Committee Member Type:Departmental Service Level:Department

Allen Institute ( Paul G. Allen Frontiers Group “Big Ideas” Session ) Special Interest Group Member Type:Service to Professional Associations Level:Prof. Org.

NIH (Special Emphasis Panel in NIH ISD Study Section ) Reviewer Type:Grant Panel Level:National

Post Graduate Training and Education

08-25-2014-06-30-2017 Post-doctoral scholar, Under Dr. Rebecca Pompano , University of Virginia Chemistry Department , ,

08-2016Flow Cytometry Core Training ,

2014GC-MS Training Workshop ,

Professional Affiliation

American Association of Immunologists

American Chemical Society

Society of Neuroscience

2008 -To Present: Alpha Chi Honor Society, Virginia Zeta Chapter

American Heart Association Member

Society of Electroanalytical Chemistry Member

Courses Taught

-CHEM-5030 UNDERGRAD RESEARCH Level:Undergraduate

Special Topics in Analytical Chemistry Level:Graduate

-CHEM-2030 SURVEY BIOCHEM I Level:Undergraduate

-CHEM-2030L SURVEY BIOCH LAB I Level:Undergraduate

Faculty Development Activities

Writing Winning Grant Proposals-NIH Type:Workshop

Early CAREER Workshop

UC Accelerator: Process, Opportunities and Mini-workshops

Course Design Institute "Designing engaging couses"

Documenting effective teaching for RPT Workshop

GATE: Models of Teaching Excellence (MOTE)

NSF CAREER Workshop NSF Washington DC Type:Workshop