Jack Rubinstein , MD

Medical Degree: Universidad Anahuac del Norte - Honors 1999

Research Fellowship: Instituto Nacional de Cardiologia Ignacio Chavez 2001

Residency: Albert Einstein Medical Center 2005 (Internal Medicine )

Chief Medical Resident : Thomas Jefferson University - Frankford Campus 2006

Fellowship : Michigan State University 2009 (Cardiology )

Chief Fellow : Michigan State University 2009 (Cardiology )

American Board of Internal Medicine (Cardiovascular Disease) (Certification Date: 11-06-2009 ) - (Recertification Date: to 11-06-2019 )

Cardiology

Cardiovascular Disease

Heart Failure

Cardiomyopathy

Coronary artery disease

Peripheral Vascular Disease (PVD)

Cardiovascular Disease

Internal Medicine

Advanced Echocardiographic Imaging, Myocardial Energy Utilization.

2009 -To Present Assistant Professor, Department of Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, OH

2009 -To Present Associate Director, Echocardiography Laboratory, University Hospital, Cincinnati, OH

2006 -2009 Clinical Instructor, Michigan State University,

Investigators:J Rubinstein 2010 -To Present Forest Pharmaceuticals Advanced Echochardiographic Study of Nebivolol Role:PI $175,000

Grant: #UL1RR026314 Investigators:J Rubinstein 2010 -2011 NIH/NCRR- CCTST Research Ethics Grant from an Institutional Clinical and Translational Science- University of Cincinnati BiDil in the Physician-Patient Relationship Role:Co-PI $10,000

Investigators:Jones, Rubinstein 2010 -2011 Internal Medicine Rehn Award High Fat is Cardioprotective in Ischemia Reperfusion Role:PI $15,000

Investigators:Rubinstein SCR/MWAFMR Moderated Poster Presentation Travel Award Prize $500

Grant: #2R01HL091478 Investigators:Ashraf, Muhammad; Jones, Walter; Ren, Xiaoping; Rubinstein, Jack 06-01-2013 -05-31-2018 National Heart, Lung and Blood Institute NF-kB-Dependent miRNAs in Cardioprotection and Regeneration Role:Collaborator $623,695.00 Active Level:Federal

Grant: #R21ES023319 Investigators:Puga, Alvaro; Rubinstein, Jack 08-29-2013 -07-31-2016 National Institute of Environmental Health Sciences Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls Role:Collaborator $326,966.00 Awarded Level:Federal

Grant: #13BGIA17140069 Investigators:Rubinstein, Jack 07-01-2013 -06-30-2015 American Heart Association - Great Rivers Affiliate Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Stimulation for the Treatment of Heart Failure Role:PI $66,000.00 Awarded Level:Private Non-Profit

Grant: #LU#206610 / R01 HL091487 Investigators:Rubinstein, Jack 08-13-2014 -05-31-2015 National Heart, Lung and Blood Institute NF-kB-dependent miRNAs in Cardioprotection and Regeneration Role:PI $8,189.00 Active Level:Federal

Grant: #1 R01 ES024744-01 Investigators:Puga, Alvaro; Rubinstein, Jack 11-10-2014 -10-31-2019 National Institute of Environmental Health Sciences Gene-Environment Interactions in the Fetal Origin of Adult Cardiac Disease Role:Collaborator $501,042.00 Awarded Level:Federal

Grant: #Check 43178 Investigators:Rubinstein, Jack 02-01-2015 -07-31-2015 Scientific Therapeutics Information, Inc. Grant Award - Tenth Annual Northwestern Cardiovascular Young Investigators' Forum Role:PI $1,000.00 Awarded Level:Industry

Grant: #R01 HL132111 Investigators:Rubinstein, Jack; Tranter, Michael 07-01-2015 -03-31-2021 National Heart, Lung and Blood Institute Investigation of Human Antigen R (HuR) as a Novel Mediator of Cardiac Hypertrophy Role:Collaborator $355,500.00 Awarded Level:Federal

Grant: #664SUB / UH54HL119810 Investigators:Rubinstein, Jack 02-01-2016 -01-31-2017 National Heart, Lung and Blood Institute Development of IV Probenecid for ADHF Role:PI $117,301.00 Active Level:Federal

Grant: #17GRNT33400014 Investigators:Rubinstein, Jack 01-01-2017 -12-31-2018 American Heart Association - Great Rivers Affiliate TRPV2 agonism for improved cardiac function in patients with single ventricle physiology Role:PI $77,000.00 Awarded Level:Private Non-Profit

Grant: #R01ES027855 Investigators:Pinney, Susan; Rubinstein, Jack; Wang, Hongsheng; Xie, Changchun 02-01-2018 -01-31-2023 National Institute of Environmental Health Sciences Endocrine Disruptors and Heart Health Role:Collaborator $429,032.00 Active Level:Federal

Grant: #R01 HL143490 Investigators:Fan, Guochang; Rubinstein, Jack; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 04-01-2019 -03-31-2023 National Institute of Allergy and Infectious Diseases IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injury Role:Collaborator $411,432.00 Awarded Level:Federal

Grant: #U01DA050330 Investigators:Amlal, Hassane; Crutchfield, Christopher; Dasenbrock-Gamm, Hanna; Kirley, Terence; Norman, Andrew; Rubinstein, Jack; Webster, Rose 09-15-2019 -07-31-2022 National Institute on Drug Abuse IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody Role:Collaborator $1,796,316.00 Awarded Level:Federal

Grant: #R38HL155775 Investigators:Rubinstein, Jack; Sadayappan, Sakthivel; Schauer, Daniel 04-01-2021 -03-31-2025 National Heart, Lung and Blood Institute Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency Program Role:PI $247,449.00 Active Level:Federal

Grant: #U01DA050330 Investigators:Amlal, Hassane; Crutchfield, Christopher; Kirley, Terence; Norman, Andrew; Rubinstein, Jack; Webster, Rose; Wetzel, Hanna 09-15-2019 -07-31-2024 National Institute on Drug Abuse IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody Role:Collaborator 0.00 Awarded Level:Federal

Grant: #2R38HL155775-05 (JIT HOLD) 12-01-2024 -11-30-2029 National Heart, Lung and Blood Institute Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency Program Role:PI 0.00 Hold Level:Federal

Grant: #2R38HL155775-05 (JIT HOLD) 12-01-2024 -11-30-2029 National Heart, Lung and Blood Institute Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency Program Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Gadeela, Nitesh; Rubinstein, Jack; Tamhane, Umesh; Huang, Ruiping; Pathak, Dorothy R; Hosein, Hazel-Ann; Rich, Michael; Dhar, Gaurav; Abela, George S (2011. ) The impact of circulating cholesterol crystals on vasomotor function implications for no-reflow phenomenon.JACC. Cardiovascular interventions, , 4 (5 ) ,521-9 More Information

Pelosi, Augusta; St John, Linda; Gaymer, Jean; Ferguson, Danielle; Goyal, Sandeep K; Abela, George S; Rubinstein, Jack (2011. ) Cardiac tissue Doppler and tissue velocity imaging in anesthetized new zealand white rabbits. Journal of the American Association for Laboratory Animal Science : JAALAS, , 50 (3 ) ,317-21

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Wang, Donna H (2010. ) Enhanced postmyocardial infarction fibrosis via stimulation of the transforming growth factor-beta-Smad2 signaling pathway: role of transient receptor potential vanilloid type 1 channels.Journal of hypertension, , 28 (2 ) ,367-76 More Information

Rubinstein, Jack; Aloka, Feras; Abela, George S (2009. ) Statin therapy decreases myocardial function as evaluated via strain imaging.Clinical cardiology, , 32 (12 ) ,684-9 More Information

Rubinstein, Jack; Pelosi, Augusta; Vedre, Ameeth; Kotaru, Pavan; Abela, George S (2009. ) Hypercholesterolemia and myocardial function evaluated via tissue doppler imaging.Cardiovascular ultrasound, , 7 ,56 More Information

Huang, Wei; Rubinstein, Jack; Prieto, Alejandro R; Thang, Loc Vinh; Wang, Donna H (2009. ) Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction.Hypertension, , 53 (2 ) ,243-50 More Information

Rubinstein, Jack; Dhoble, Abhijeet; Ferenchick, Gary (2009. ) Puzzle based teaching versus traditional instruction in electrocardiogram interpretation for medical students--a pilot study.BMC medical education, , 9 ,4 More Information

Tanaka, Tomoko; Ling, Benjamin C; Rubinstein, Jack H; Crone, Kerry R (2006. ) Rubinstein-Taybi syndrome in children with tethered spinal cord.Journal of neurosurgery, , 105 (4 Suppl ) ,261-4 More Information

Naimi, David R; Munoz, Jose; Rubinstein, Jack; Hostoffer, Robert W Rubinstein-Taybi syndrome: an immune deficiency as a cause for recurrent infections. Allergy and asthma proceedings : the official journal of regional and state allergy societies, , 27 (3 ) ,281-4

Rubinstein, Jack (2005. ) Amiodarone versus sotalol for atrial fibrillation.The New England journal of medicine, , 353 (6 ) ,627-30; author reply More Information

Rubinstein, Jack; Moghe, Rohit; Mizrachi, Alberto; Dissin, Jonathan Triptan use preceding life-threatening arrhythmias in charcot-marie-tooth: a case report and review of the literature. Clinical neuropharmacology, , 27 (1 ) ,14-6

Wiley, Susan; Swayne, Susan; Rubinstein, Jack H; Lanphear, Nancy E; Stevens, Cathy A (2003. ) Rubinstein-Taybi syndrome medical guidelines.American journal of medical genetics. Part A, , 119A (2 ) ,101-10 More Information

Robbins, Nathan; Koch, Sheryl E; Rubinstein, Jack (2013. ) Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease.Translational research : the journal of laboratory and clinical medicine, , More Information

Yan, Sujuan; Song, Weizhong; Chen, Yamei; Hong, Kui; Rubinstein, Jack; Wang, Hong-Sheng (2013. ) Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia-reperfusion in female rat hearts.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , 56C ,75-80 More Information

Lam, Chi Keung; Zhao, Wen; Cai, Wenfeng; Vafiadaki, Elizabeth; Florea, Stela M; Ren, Xiaoping; Liu, Yong; Robbins, Nathan; Zhang, Zhiguo; Zhou, Xiaoyang; Jiang, Min; Rubinstein, Jack; Jones, W Keith; Kranias, Evangelia G (2013. ) Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90.Circulation research, , 112 (1 ) ,79-89 More Information

Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack (2012. ) Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model.Journal of cardiovascular pharmacology and therapeutics, , More Information

Florea, Stela; Anjak, Ahmad; Cai, Wen-Feng; Qian, Jiang; Vafiadaki, Elizabeth; Figueria, Sarah; Haghighi, Kobra; Rubinstein, Jack; Lorenz, John; Kranias, Evangelia G (2012. ) Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging.Basic research in cardiology, , 107 (5 ) ,279 More Information

Chen, Lijuan; Ashraf, Muhammad; Wang, Yingjie; Zhou, Mi; Zhang, John; Qin, Gangjian; Rubinstein, Jack; Weintraub, Neal L; Tang, Yaoliang (2012. ) The role of notch 1 activation in cardiosphere derived cell differentiation.Stem cells and development, , 21 (12 ) ,2122-9 More Information

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack (2012. ) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.Journal of molecular and cellular cardiology, , 53 (1 ) ,134-44 More Information

Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack (2012. ) The history and future of probenecid.Cardiovascular toxicology, , 12 (1 ) ,1-9 More Information

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G (2012. ) The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.Journal of molecular and cellular cardiology, , 52 (3 ) ,773-82 More Information

Lather, Navneet; Efeovbokhan, Nephertiti; Hakeem, Abdul; Kotaru, Pavan; Abela, George S; Burger, Andrew J; Rubinstein, Jack (2011. ) Advanced echocardiographic imaging to predict exercise capacity in relatively healthy women.International journal of cardiology, , 151 (3 ) ,369-71 More Information

Patel, Roshan; Janoudi, Abed; Vedre, Ameeth; Aziz, Kusai; Tamhane, Umesh; Rubinstein, Jack; Abela, Oliver G; Berger, Kevin; Abela, George S (2011. ) Plaque rupture and thrombosis are reduced by lowering cholesterol levels and crystallization with ezetimibe and are correlated with fluorodeoxyglucose positron emission tomography.Arteriosclerosis, thrombosis, and vascular biology, , 31 (9 ) ,2007-14 More Information

2010 Northwestern Cardiovascular Young Investigators Forum Finalist Chicago, IL - Role of Transient Receptor Potential Vanilloid Channels in Cardiac Function and Cardioprotection

2009 Ignacio Chavez Award Oral Presentation - XXII Congreso Interamericano de Cardiologia - Interamerican Congress of Cardiology - Puerto Rico - Statin Therapy Decreases Myocardial Function as Evaluated Via Strain Rate Imaging

2010 Travel Award Prize SCR/MWAFMR Moderated Poster Presentation - Chicago, IL - Transient Receptor Postential Vanilloid 2 (TRPV2) Stimulation is Cardioprotective

2009 First Prize Award for Oral Presentation 4th Annual Lansing Research Day- Lansing, Michigan - Statin Therapy Decreases Myocardial Function as Evaluated via Strain Rate Imaging - Rubinstein J, Aloka F, Abela GS

2008 First Prize 20th Annual Conference of the Michigan Chapter of the American College of Cardiology - Traverse City, Michigan - Cholesterol Crystals Cause Endothelial Damage and Impair Vasoreactivity - Gadeela N, Rubinstein J, Huang R, Abela GS

2008 Finalist Northwestern Cardiovascular Young Investigators Forum - Chicago, IL - Computerized Tomography can Estimate Myocardial Cholesterol Content: A Novel Approach to Evaluate Myocardial Function

2008 First Prize Award Oral Presentation - 3rd Annual Lansing Research Day - Lansing Michigan - Cardioprotective Effect of Ezetimbe After Thrombus Triggering in an Atheroscelortic Model

Jack Rubinstein, myocardial, heart, cardiac, heart disease, cardiovascular, cardiology

Academic - Medical Sciences Building
231 Albert Sabin Way, MLC 0542
Cincinnati  Ohio, 45267
Phone: (513) 558-3062
jack.rubinstein@uc.edu