Sakthivel Sadayappan

Sakthivel Sadayappan

Professor, Department of Internal Medicine; Division of Cardiovascular Health and Disease; Director of Heart Branch of the UC Heart, Lung and Vascular Institute

Cardiovascular Rsrch Cntr

4935

COM IM Cardiology Division - 0542

Cardiovascular Center, Room 4935, 4th Floor
231 Albert Sabin Way
Cincinnati, Ohio 45267-0542

Professional Summary

The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. The sarcomere is the functional unit of striated muscle to generate contractility. Accordingly, the Sadayappan Lab has consistently focused on improving cardiac sarcomere function during ischemia-reperfusion injury. We have learned that sarcomere proteins undergo severe proteolytic damage during ischemia-reperfusion injury, resulting decreased contractile force and cardiac function. Therefore, the short-term goals of current research studies involve 1) identifying cardiac-specific early biomarkers of HF (NIH-NHLBI K02HL114749), 2) restoring sarcomere structure and function (NIH-NHLBI R01HL105826), and 3) screening for compounds to improve sarcomere function during ischemia-reperfusion injury. In particular, hypertrophic cardiomyopathy (HCM) is a major genetic disorder among populations of South Asian descent, leading to contractile dysfunction, heart failure, and sudden cardiac death. Therefore, we are also engaged in determining the pathophysiological mechanism of the South Asian-specific MYBPC3 gene variant that has been associated with the development of HCM. Using various mouse models and in vitro culture systems expressing the MYBPC3 gene variant, we aim to unravel the molecular mechanisms associated this mutant (NIH-NHLBI R01HL130356). To carry out this study, we are performing genome-phenome analysis in South Asians who carry the MYBPC3 gene variant and who live in the USA (AHA 15CVGPSD27020012). Finally, in an unrelated, but nonetheless pivotal, study, we are studying the differential role(s) of slow and fast myosin binding protein-C in skeletal muscles (R01AR067279, PI: Craig and Warshaw), using both in vitro culture systems and animal models. As part of our commitment to the development of young scientists, the Sadayappan Lab provides expertise and training in cell biology, molecular biology, structural biology and physiology of the muscle and encourages collaborations in various areas of muscle biology. 

Research Support

Grant: #15CVGPSD27020012 Investigators:Sadayappan, Sakthivel 08-15-2016 -11-30-2016 American Heart Association - National Chapter A polymorphic MYBPC3 variant as a major risk factor of cardiomyopathy in South Asian descendants Role:PI $29,700.01 Active Level:Private Non-Profit

Grant: #UMass OSP2017118 sub R01AR067279 Investigators:Sadayappan, Sakthivel 08-15-2016 -06-30-2020 National Institute of Arthritis, Musculoskeletal and Skin Disease Skeletal myosin-binding protein C (MyBP-C): molecular structure and function Role:PI $16,337.99 Awarded Level:Federal

Grant: #R01 HL130356 Investigators:Lorenz, John; Sadayappan, Sakthivel 03-06-2017 -12-31-2019 National Heart, Lung and Blood Institute Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendants Role:PI $405,408.00 Awarded Level:Federal

Grant: #K02HL114749 Investigators:Sadayappan, Sakthivel 04-01-2017 -07-31-2017 National Heart, Lung and Blood Institute Proteomic approaches to validate novel cardiac biomarkers for myocardial infarcti Role:PI $126,653.00 Active Level:Federal

Grant: #R01 HL105826 Investigators:Sadayappan, Sakthivel 04-07-2017 -03-31-2020 National Heart, Lung and Blood Institute Cardiac Myosin Binding Protein-C: Structure and Function Role:PI $391,511.00 Awarded Level:Federal

Grant: #17CCRG33671128 Investigators:Sadayappan, Sakthivel 05-01-2017 -04-30-2018 American Heart Association - National Chapter A novel polymorphic MYBPC3 variant causes hypertrophic cardiomyopathy in US-South Asian descendants Role:PI $250,000.00 Active Level:Private Non-Profit

Grant: #17PRE33630192 Investigators:Kumar, Mohit; Sadayappan, Sakthivel 07-01-2017 -06-30-2019 American Heart Association - Great Rivers Affiliate Role(s) of myosin binding protein-C phosphorylation in cardiac arrhythmias Role:Collaborator $26,844.00 Active Level:Private Non-Profit

Grant: #134164 / T32 HL125204 Investigators:Kerr, Jennifer; Sadayappan, Sakthivel 07-03-2017 -07-02-2018 National Heart, Lung and Blood Institute T32 appointment on T32HL125204 Role:Collaborator $47,484.00 Active Level:Federal

Grant: #19UFEL34380251 Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2021 American Heart Association - National Chapter American Heart Association - Summer Undergraduate Research Fellowship (AHA-SURF) Role:PI $60,000.00 Awarded Level:Private Non-Profit

Grant: #R01 HL143490 Investigators:Fan, Guochang; Rubinstein, Jack; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 04-01-2019 -03-31-2023 National Institute of Allergy and Infectious Diseases IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injury Role:Collaborator $411,432.00 Awarded Level:Federal

Grant: #Ocean Research/ R56HL139680 Investigators:Sadayappan, Sakthivel 09-24-2018 -08-31-2019 National Heart, Lung and Blood Institute Myoarchitectural basis of heart failure Role:PI $160,126.76 Awarded Level:Federal

Grant: #2019 Research Agreement Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2019 MyoKardia, Inc. Hypertrophic cardiomyopathy in populations of South Asian descendants Role:PI $250,000.00 Awarded Level:Industry

Grant: #2019-2020 Fellowship Investigators:Feldman, Jacob; Sadayappan, Sakthivel 04-01-2019 -03-30-2020 National Heart, Lung and Blood Institute N’-terminal truncated cMyBP-C Myocytes influence on Length dependent activation Role:PI $1,600.00 Awarded Level:Federal

Grant: #2019 Master Visting Post Doc Agreement Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2021 Amgen, Inc Amgen - Master Visiting Post Doctoral Scientist Program Role:PI $40,000.00 Active Level:Industry

Grant: #19TPA34830084 Investigators:Kranias, Evangelia; Sadayappan, Sakthivel 07-01-2019 -06-30-2022 American Heart Association - National Chapter Molecular Mechanisms of Cardiac Arrhythmias in Patients with Compound Mutations Role:PI $100,000.00 Awarded Level:Private Non-Profit

Grant: #20PRE35120272 Investigators:Desai, Darshini; Sadayappan, Sakthivel 01-01-2020 -12-31-2021 American Heart Association - National Chapter Human cardiac organoids for hypertrophic cardiomyopathy . Role:PI $31,016.00 Active Level:Private Non-Profit

Publications

Peer Reviewed Publications

Lynch, Thomas L; Ismahil, Mohamed Ameen; Jegga, Anil G; Zilliox, Michael J; Troidl, Christian; Prabhu, Sumanth D; Sadayappan, Sakthivel (2016. )Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.Journal of molecular and cellular cardiology, ,102 ,83-93

Kraker, Jessica; Viswanathan, Shiv Kumar; Knöll, Ralph; Sadayappan, Sakthivel (2016. )Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants.Frontiers in physiology, ,7 ,499

Taylor, Erik N; Hoffman, Matthew P; Barefield, David Y; Aninwene, George E; Abrishamchi, Aurash D; Lynch, Thomas L; Govindan, Suresh; Osinska, Hanna; Robbins, Jeffrey; Sadayappan, Sakthivel; Gilbert, Richard J (2016. )Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.Journal of the American Heart Association, ,5 (3 ),e002836

Howarth, Jack W; Ramisetti, Srinivas; Nolan, Kristof; Sadayappan, Sakthivel; Rosevear, Paul R (2012. )Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain.The Journal of biological chemistry, ,287 (11 ),8254-62

Nicolaou, Persoulla; Rodriguez, Patricia; Ren, Xiaoping; Zhou, Xiaoyang; Qian, Jiang; Sadayappan, Sakthivel; Mitton, Bryan; Pathak, Anand; Robbins, Jeffrey; Hajjar, Roger J; Jones, Keith; Kranias, Evangelia G (2009. )Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.Circulation research, ,104 (8 ),1012-20

Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey (2009. )Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.Circulation, ,119 (9 ),1253-62

Sadayappan, Sakthivel; Finley, Natosha; Howarth, Jack W; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Rosevear, Paul R; Robbins, Jeffrey (2008. )Role of the acidic N' region of cardiac troponin I in regulating myocardial function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,22 (4 ),1246-57

Sadayappan, Sakthivel; Robbins, Jeffrey (2008. )The death of transcriptional chauvinism in the control and regulation of cardiac contractility.Annals of the New York Academy of Sciences, ,1123 ,1-9

Krenz, Maike; Sadayappan, Sakthivel; Osinska, Hanna E; Henry, Jeffrey A; Beck, Samantha; Warshaw, David M; Robbins, Jeffrey (2007. )Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.The Journal of biological chemistry, ,282 (33 ),24057-64

Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2006. )Cardiac myosin binding protein C phosphorylation is cardioprotective.Proceedings of the National Academy of Sciences of the United States of America, ,103 (45 ),16918-23

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Martin, Lisa A; Hahn, Harvey S; Dorn, Gerald W; Klevitsky, Raisa; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2005. )Cardiac myosin-binding protein-C phosphorylation and cardiac function.Circulation research, ,97 (11 ),1156-63

Barefield, David Y; Lynch, Thomas L; Jagadeesan, Aravindakshan; Sanagala, Thriveni; Sadayappan, Sakthivel (2016. )High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant.Journal of molecular biomarkers & diagnosis, ,7 (6 ),

Hoffman, Matthew P; Taylor, Erik N; Aninwene, George E; Sadayappan, Sakthivel; Gilbert, Richard J (2016. )Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.Microscopy research and technique, ,

Lipps, Christoph; Nguyen, Jenine H; Pyttel, Lukas; Lynch, Thomas L; Liebetrau, Christoph; Aleshcheva, Ganna; Voss, Sandra; Dörr, Oliver; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Sadayappan, Sakthivel; Troidl, Christian (2016. )N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.Journal of molecular and cellular cardiology, ,99 ,47-56

Stathopoulou, Konstantina; Wittig, Ilka; Heidler, Juliana; Piasecki, Angelika; Richter, Florian; Diering, Simon; van der Velden, Jolanda; Buck, Friedrich; Donzelli, Sonia; Schröder, Ewald; Wijnker, Paul J M; Voigt, Niels; Dobrev, Dobromir; Sadayappan, Sakthivel; Eschenhagen, Thomas; Carrier, Lucie; Eaton, Philip; Cuello, Friederike (2016. )S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,30 (5 ),1849-64

Kumar, Mohit; Govindan, Suresh; Zhang, Mengjie; Khairallah, Ramzi J; Martin, Jody L; Sadayappan, Sakthivel; de Tombe, Pieter P (2015. )Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.The Journal of biological chemistry, ,290 (49 ),29241-9

Thoonen, Robrecht; Giovanni, Shewit; Govindan, Suresh; Lee, Dong I; Wang, Guang-Rong; Calamaras, Timothy D; Takimoto, Eiki; Kass, David A; Sadayappan, Sakthivel; Blanton, Robert M (2015. )Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-I? Substrate.Circulation. Heart failure, ,8 (6 ),1115-22

Tong, Carl W; Wu, Xin; Liu, Yang; Rosas, Paola C; Sadayappan, Sakthivel; Hudmon, Andy; Muthuchamy, Mariappan; Powers, Patricia A; Valdivia, Héctor H; Moss, Richard L (2015. )Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or ?1-Adrenergic Stimulation.Circulation. Heart failure, ,8 (3 ),595-604

Kuster, Diederik W D; Govindan, Suresh; Springer, Tzvia I; Martin, Jody L; Finley, Natosha L; Sadayappan, Sakthivel (2015. )A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.The Journal of biological chemistry, ,290 (9 ),5855-67

Barefield, David; Kumar, Mohit; Gorham, Joshua; Seidman, Jonathan G; Seidman, Christine E; de Tombe, Pieter P; Sadayappan, Sakthivel (2015. )Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Journal of molecular and cellular cardiology, ,79 ,234-43

Lee, Kyounghwan; Harris, Samantha P; Sadayappan, Sakthivel; Craig, Roger (2015. )Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM.Journal of molecular biology, ,427 (2 ),274-86

Lynch, Thomas L; Sivaguru, Mayandi; Velayutham, Murugesan; Cardounel, Arturo J; Michels, Michelle; Barefield, David; Govindan, Suresh; dos Remedios, Cristobal; van der Velden, Jolanda; Sadayappan, Sakthivel (2015. )Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.Oxidative medicine and cellular longevity, ,2015 ,424751

Wilson, Kristin; Guggilam, Anuradha; West, T Aaron; Zhang, Xiaojin; Trask, Aaron J; Cismowski, Mary J; de Tombe, Pieter; Sadayappan, Sakthivel; Lucchesi, Pamela A (2014. )Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure.American journal of physiology. Heart and circulatory physiology, ,307 (11 ),H1605-17

Wang, Li; Sadayappan, Sakthivel; Kawai, Masakata (2014. )Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.PloS one, ,9 (11 ),e113417

Helms, Adam S; Davis, Frank M; Coleman, David; Bartolone, Sarah N; Glazier, Amelia A; Pagani, Francis; Yob, Jaime M; Sadayappan, Sakthivel; Pedersen, Ellen; Lyons, Robert; Westfall, Margaret V; Jones, Richard; Russell, Mark W; Day, Sharlene M (2014. )Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy.Circulation. Cardiovascular genetics, ,7 (4 ),434-43

Lynch, Thomas L; Sadayappan, Sakthivel (2014. )Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium.Proteomics. Clinical applications, ,8 (7-8 ),569-77

Haynes, Premi; Nava, Kristofer E; Lawson, Benjamin A; Chung, Charles S; Mitov, Mihail I; Campbell, Stuart G; Stromberg, Arnold J; Sadayappan, Sakthivel; Bonnell, Mark R; Hoopes, Charles W; Campbell, Kenneth S (2014. )Transmural heterogeneity of cellular level power output is reduced in human heart failure.Journal of molecular and cellular cardiology, ,72 ,1-8

Hoffmann, Jedrzej; Ospelt, Manuel; Troidl, Christian; Voss, Sandra; Liebetrau, Christoph; Kim, Won-Keun; Rolf, Andreas; Wietelmann, Astrid; Braun, Thomas; Troidl, Kerstin; Sadayappan, Sakthivel; Barefield, David; Hamm, Christian; Nef, Holger; Möllmann, Helge (2014. )Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction.PloS one, ,9 (6 ),e98456

Witayavanitkul, Namthip; Ait Mou, Younss; Kuster, Diederik W D; Khairallah, Ramzi J; Sarkey, Jason; Govindan, Suresh; Chen, Xin; Ge, Ying; Rajan, Sudarsan; Wieczorek, David F; Irving, Thomas; Westfall, Margaret V; de Tombe, Pieter P; Sadayappan, Sakthivel (2014. )Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.The Journal of biological chemistry, ,289 (13 ),8818-27

Wang, Li; Ji, Xiang; Barefield, David; Sadayappan, Sakthivel; Kawai, Masakata (2014. )Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner.Biophysical journal, ,106 (5 ),1112-22

Barefield, David; Kumar, Mohit; de Tombe, Pieter P; Sadayappan, Sakthivel (2014. )Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.American journal of physiology. Heart and circulatory physiology, ,306 (6 ),H807-15

Kuster, Diederik W D; Cardenas-Ospina, Adriana; Miller, Lawson; Liebetrau, Christoph; Troidl, Christian; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Pieper, Karen S; Mahaffey, Kenneth W; Kleiman, Neal S; Stuyvers, Bruno D; Marian, Ali J; Sadayappan, Sakthivel (2014. )Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury.American journal of physiology. Heart and circulatory physiology, ,306 (4 ),H547-56

Gao, Xianlong; Lin, Brian; Sadayappan, Sakthivel; Patel, Tarun B (2014. )Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.Molecular pharmacology, ,85 (2 ),357-67

Kuster, Diederik W D; Sadayappan, Sakthivel (2014. )MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation.Pflugers Archiv : European journal of physiology, ,466 (2 ),207-13

Sadayappan, Sakthivel; de Tombe, Pieter P (2014. )Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.Pflugers Archiv : European journal of physiology, ,466 (2 ),195-200

Simon, Jillian N; Chowdhury, Shamim A K; Warren, Chad M; Sadayappan, Sakthivel; Wieczorek, David F; Solaro, R John; Wolska, Beata M (2014. )Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.Basic research in cardiology, ,109 (6 ),445

Khairallah, Ramzi J; Sadayappan, Sakthivel (2013. )Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach.Proteomics, ,13 (22 ),3245-6

Kuster, Diederik W D; Barefield, David; Govindan, Suresh; Sadayappan, Sakthivel (2013. )A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay.Journal of visualized experiments : JoVE, ,(78 ),

Lin, Brian; Govindan, Suresh; Lee, Kyounghwan; Zhao, Piming; Han, Renzhi; Runte, K Elisabeth; Craig, Roger; Palmer, Bradley M; Sadayappan, Sakthivel (2013. )Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function.PloS one, ,8 (7 ),e69671

Govindan, Suresh; Kuster, Diederik Wd; Lin, Brian; Kahn, Daniel J; Jeske, Walter P; Walenga, Jeanine M; Leya, Fred; Hoppensteadt, Debra; Fareed, Jawed; Sadayappan, Sakthivel (2013. )Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. American journal of cardiovascular disease, ,3 (2 ),60-70

Kuster, Diederik W D; Sequeira, Vasco; Najafi, Aref; Boontje, Nicky M; Wijnker, Paul J M; Witjas-Paalberends, E Rosalie; Marston, Steven B; Dos Remedios, Cristobal G; Carrier, Lucie; Demmers, Jeroen A A; Redwood, Charles; Sadayappan, Sakthivel; van der Velden, Jolanda (2013. )GSK3? phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.Circulation research, ,112 (4 ),633-9

Hinken, Aaron C; Hanft, Laurin M; Scruggs, Sarah B; Sadayappan, Sakthivel; Robbins, Jeffery; Solaro, R John; McDonald, Kerry S (2012. )Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.Journal of muscle research and cell motility, ,33 (6 ),439-48

Verma, Suresh Kumar; Krishnamurthy, Prasanna; Barefield, David; Singh, Neha; Gupta, Rajesh; Lambers, Erin; Thal, Melissa; Mackie, Alexander; Hoxha, Eneda; Ramirez, Veronica; Qin, Gangjian; Sadayappan, Sakthivel; Ghosh, Asish K; Kishore, Raj (2012. )Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B.Circulation, ,126 (4 ),418-29

Sadayappan, Sakthivel; de Tombe, Pieter P (2012. )Cardiac myosin binding protein-C: redefining its structure and function.Biophysical reviews, ,4 (2 ),93-106

Govindan, Suresh; Sarkey, Jason; Ji, Xiang; Sundaresan, Nagalingam R; Gupta, Mahesh P; de Tombe, Pieter P; Sadayappan, Sakthivel (2012. )Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.Journal of muscle research and cell motility, ,33 (1 ),17-30

Govindan, Suresh; McElligott, Andrew; Muthusamy, Saminathan; Nair, Nandini; Barefield, David; Martin, Jody L; Gongora, Enrique; Greis, Kenneth D; Luther, Pradeep K; Winegrad, Saul; Henderson, Kyle K; Sadayappan, Sakthivel (2012. )Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.Journal of molecular and cellular cardiology, ,52 (1 ),154-64

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey (2011. )A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.Circulation research, ,109 (2 ),141-50

Barefield, David; Sadayappan, Sakthivel (2010. )Phosphorylation and function of cardiac myosin binding protein-C in health and disease.Journal of molecular and cellular cardiology, ,48 (5 ),866-75

Tong, Carl W; Dusio, Giuseppina F; Govindan, Suresh; Johnson, Dustin W; Kidwell, David T; De La Rosa, Lisa M; Rosas, Paola C; Liu, Yang; Ebert, Elizabeth; Newell-Rogers, M Karen; Michel, Jeffrey B; Trzeciakowski, Jerome P; Sadayappan, Sakthivel (2017. )Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.The American journal of cardiology, ,120 (9 ),1501-1507

Grimes, Kelly M; Barefield, David Y; Kumar, Mohit; McNamara, James W; Weintraub, Susan T; de Tombe, Pieter P; Sadayappan, Sakthivel; Buffenstein, Rochelle (2017. )The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.Pflugers Archiv : European journal of physiology, ,

Lynch, Thomas L; Kuster, Diederik W D; Gonzalez, Beverly; Balasubramanian, Neelam; Nair, Nandini; Day, Sharlene; Calvino, Jenna E; Tan, Yanli; Liebetrau, Christoph; Troidl, Christian; Hamm, Christian W; Güçlü, Ahmet; McDonough, Barbara; Marian, Ali J; van der Velden, Jolanda; Seidman, Christine E; Huggins, Gordon S; Sadayappan, Sakthivel (2017. )Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome.JACC. Basic to translational science, ,2 (2 ),122-131

Lin, Brian Leei; Song, Taejeong; Sadayappan, Sakthivel (2017. )Myofilaments: Movers and Rulers of the Sarcomere.Comprehensive Physiology, ,7 (2 ),675-692

Research and Practice Interests

Contact Information

Academic - Cardiovascular Center, Room 4935, 4th Floor
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0542
Phone: 513-558-7498
Fax: 513-558-2884
sadayasl@uc.edu