Sakthivel Sadayappan

Sakthivel Sadayappan , Ph.D., M.B.A.

Professor

Vice Chair of Basic Research, Internal Medicine; Director of Heart Branch of the UC Heart, Lung and Vascular Institute; Division of Cardiovascular Health and Disease;

Cardiovascular Center, Room 4935, 4th Floor
231 Albert Sabin Way
MLC 0542
Cincinnati, Ohio 45267-0542
Phone 513-558-7498
Fax 513-558-2884
Email sadayasl@ucmail.uc.edu

Professional Summary

The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. The sarcomere is the functional unit of striated muscle to generate contractility. Accordingly, the Sadayappan Lab has consistently focused on improving cardiac sarcomere function during ischemia-reperfusion injury. We have learned that sarcomere proteins undergo severe proteolytic damage during ischemia-reperfusion injury, resulting decreased contractile force and cardiac function. Therefore, the short-term goals of current research studies involve 1) identifying cardiac-specific early biomarkers of HF (NIH-NHLBI K02HL114749), 2) restoring sarcomere structure and function (NIH-NHLBI R01HL105826), and 3) screening for compounds to improve sarcomere function during ischemia-reperfusion injury. In particular, hypertrophic cardiomyopathy (HCM) is a major genetic disorder among populations of South Asian descent, leading to contractile dysfunction, heart failure, and sudden cardiac death. Therefore, we are also engaged in determining the pathophysiological mechanism of the South Asian-specific MYBPC3 gene variant that has been associated with the development of HCM. Using various mouse models and in vitro culture systems expressing the MYBPC3 gene variant, we aim to unravel the molecular mechanisms associated this mutant (NIH-NHLBI R01HL130356). To carry out this study, we are performing genome-phenome analysis in South Asians who carry the MYBPC3 gene variant and who live in the USA (AHA 15CVGPSD27020012). Finally, in an unrelated, but nonetheless pivotal, study, we are studying the differential role(s) of slow and fast myosin binding protein-C in skeletal muscles (R01AR067279, PI: Craig and Warshaw), using both in vitro culture systems and animal models. As part of our commitment to the development of young scientists, the Sadayappan Lab provides expertise and training in cell biology, molecular biology, structural biology and physiology of the muscle and encourages collaborations in various areas of muscle biology. 

Education

MBA: University of Cincinnati Cincinnati, OH, 2009 (Project Administration and Marketing )

PhD: Madurai Kamaraj University Madurai, India, 1999 (Molecular Aspects of Cardiac Hypertrophy)

Research and Practice Interests

The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. 

Positions and Work Experience

01-01-2019 - Associate Chair for Basic Research, Internal Medicine, University of Cincinnati, College of Medicine, Cincinnati, OH

08-16-2016 - Professor of Medicine, University of Cincinnati, College of Medicine, Cincinnati, OH

08-16-2016 - Director of Heart Research, Heart Lung and Vascular Institute, University of Cincinnati, College of Medicine, Cincinnati, OH

07-01-2014 -08-15-2016 Associate Professor, Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, IL

09-01-2009 -06-30-2014 Assistant Professor , Loyola University Chicago, Department of Cell and Molecular Physiology, Chicago, IL

12-01-2006 -08-31-2009 Research Instructor , Children’s Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, OH

06-01-2002 -05-31-2005 Postdoctoral Fellow, Cincinnati Children’s Hospital, Division of Molecular Cardiovascular Biology, Cincinnati, OH

06-01-2005 -11-30-2006 Research Associate, Cincinnati Children’s Hospital, Division of Molecular Cardiovascular Biology, Cincinnati, OH

12-01-1998 -05-31-2002 Postdoctoral Research Fellow, Max-Planck-Institute, Experimental Cardiology, Bad Nauheim, Germany

10-01-1993 -11-30-1998 Graduate Student, Madurai Kamaraj University, Biochemistry, India

Research Support

Grant: #15CVGPSD27020012 Investigators:Sadayappan, Sakthivel 08-15-2016 -11-30-2016 American Heart Association - National Chapter A polymorphic MYBPC3 variant as a major risk factor of cardiomyopathy in South Asian descendants Role:PI $29,700.01 Active Level:Private Non-Profit

Grant: #UMass OSP2017118 sub R01AR067279 Investigators:Sadayappan, Sakthivel 08-15-2016 -06-30-2020 National Institute of Arthritis, Musculoskeletal and Skin Disease Skeletal myosin-binding protein C (MyBP-C): molecular structure and function Role:PI $16,337.99 Awarded Level:Federal

Grant: #R01 HL130356 Investigators:Lorenz, John; Sadayappan, Sakthivel 03-06-2017 -12-31-2019 National Heart, Lung and Blood Institute Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendants Role:PI $405,408.00 Awarded Level:Federal

Grant: #K02HL114749 Investigators:Sadayappan, Sakthivel 04-01-2017 -07-31-2017 National Heart, Lung and Blood Institute Proteomic approaches to validate novel cardiac biomarkers for myocardial infarcti Role:PI $126,653.00 Active Level:Federal

Grant: #R01 HL105826 Investigators:Sadayappan, Sakthivel 04-07-2017 -03-31-2020 National Heart, Lung and Blood Institute Cardiac Myosin Binding Protein-C: Structure and Function Role:PI $391,511.00 Awarded Level:Federal

Grant: #17CCRG33671128 Investigators:Sadayappan, Sakthivel 05-01-2017 -04-30-2018 American Heart Association - National Chapter A novel polymorphic MYBPC3 variant causes hypertrophic cardiomyopathy in US-South Asian descendants Role:PI $250,000.00 Active Level:Private Non-Profit

Grant: #17PRE33630192 Investigators:Kumar, Mohit; Sadayappan, Sakthivel 07-01-2017 -06-30-2019 American Heart Association - Great Rivers Affiliate Role(s) of myosin binding protein-C phosphorylation in cardiac arrhythmias Role:Collaborator $26,844.00 Active Level:Private Non-Profit

Grant: #134164 / T32 HL125204 Investigators:Kerr, Jennifer; Sadayappan, Sakthivel 07-03-2017 -07-02-2018 National Heart, Lung and Blood Institute T32 appointment on T32HL125204 Role:Collaborator $47,484.00 Active Level:Federal

Grant: #19UFEL34380251 Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2021 American Heart Association - National Chapter American Heart Association - Summer Undergraduate Research Fellowship (AHA-SURF) Role:PI $60,000.00 Awarded Level:Private Non-Profit

Grant: #R01 HL143490 Investigators:Fan, Guochang; Rubinstein, Jack; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 04-01-2019 -03-31-2023 National Institute of Allergy and Infectious Diseases IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injury Role:Collaborator $411,432.00 Awarded Level:Federal

Grant: #Ocean Research/ R56HL139680 Investigators:Sadayappan, Sakthivel 09-24-2018 -08-31-2019 National Heart, Lung and Blood Institute Myoarchitectural basis of heart failure Role:PI $160,126.76 Awarded Level:Federal

Grant: #2019 Research Agreement Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2019 MyoKardia, Inc. Hypertrophic cardiomyopathy in populations of South Asian descendants Role:PI $250,000.00 Awarded Level:Industry

Grant: #2019-2020 Fellowship Investigators:Feldman, Jacob; Sadayappan, Sakthivel 04-01-2019 -03-30-2020 National Heart, Lung and Blood Institute N’-terminal truncated cMyBP-C Myocytes influence on Length dependent activation Role:PI $1,600.00 Awarded Level:Federal

Grant: #2019 Master Visting Post Doc Agreement Investigators:Sadayappan, Sakthivel 01-01-2019 -12-31-2021 Amgen, Inc Amgen - Master Visiting Post Doctoral Scientist Program Role:PI $40,000.00 Active Level:Industry

Grant: #19TPA34830084 Investigators:Kranias, Evangelia; Sadayappan, Sakthivel 07-01-2019 -06-30-2022 American Heart Association - National Chapter Molecular Mechanisms of Cardiac Arrhythmias in Patients with Compound Mutations Role:PI $100,000.00 Awarded Level:Private Non-Profit

Grant: #20PRE35120272 Investigators:Desai, Darshini; Sadayappan, Sakthivel 01-01-2020 -12-31-2021 American Heart Association - National Chapter Human cardiac organoids for hypertrophic cardiomyopathy . Role:PI $31,016.00 Active Level:Private Non-Profit

Grant: #Research Study Investigators:Kranias, Evangelia; Sadayappan, Sakthivel 09-01-2019 -08-31-2020 Netherlands Heart Institute Preclinical studies to improve contractile function in Humanized mouse model expressing R14del-phospholamban with heart failure. Role:PI $30,000.00 Active Level:Foreign Non-Profit

Grant: #R01AR078001 Investigators:Heiny, Judith; Lorenz, John; Sadayappan, Sakthivel 08-15-2020 -07-31-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Slow myosin binding protein-C in skeletal muscle physiology Role:PI $453,512.00 Active Level:Federal

Grant: #R38HL155775 Investigators:Rubinstein, Jack; Sadayappan, Sakthivel; Schauer, Daniel 04-01-2021 -03-31-2025 National Heart, Lung and Blood Institute Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency Program Role:Collaborator $247,449.00 Active Level:Federal

Investigators:Lorenz, John; Sadayappan, Sakthivel 09-01-2021 -01-31-2022 Novo Nordisk A/S Novonordisk Role:PI 146894.22 Hold Level:Industry

Grant: #S10OD030402 Investigators:Closson, Chet; Fan, Guochang; Hong, Christian; Luo, Yu; Sadayappan, Sakthivel; Wang, Hongsheng; Weiss, Alison; Zhang, Yuhang 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Leica Stellaris 8 Confocal Microscope Role:Collaborator 598148.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Becker, Richard C; Owens, A Phillip; Sadayappan, Sakthivel (2020. ) Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy.Journal of thrombosis and thrombolysis, , 49 (2 ) ,177-183 More Information

Vagnozzi, Ronald J; Maillet, Marjorie; Sargent, Michelle A; Khalil, Hadi; Johansen, Anne Katrine Z; Schwanekamp, Jennifer A; York, Allen J; Huang, Vincent; Nahrendorf, Matthias; Sadayappan, Sakthivel; Molkentin, Jeffery D (2020. ) An acute immune response underlies the benefit of cardiac stem cell therapy.Nature, , 577 (7790 ) ,405-409 More Information

Kuster, Diederik W D; Lynch, Thomas L; Barefield, David Y; Sivaguru, Mayandi; Kuffel, Gina; Zilliox, Michael J; Lee, Kyoung Hwan; Craig, Roger; Namakkal-Soorappan, Rajasekaran; Sadayappan, Sakthivel (2019. ) Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.Cardiovascular research, , 115 (14 ) ,1986-1997 More Information

Vagnozzi, Ronald J; Pfleger, Jessica; Sadayappan, Sakthivel (2019. ) Basic Cardiovascular Sciences Scientific Sessions 2019: Integrative Approaches to Complex Cardiovascular Diseases.Circulation research, , 125 (10 ) ,924-931 More Information

Li, Amy; Nelson, Shane R; Rahmanseresht, Sheema; Braet, Filip; Cornachione, Anabelle S; Previs, Samantha Beck; O'Leary, Thomas S; McNamara, James W; Rassier, Dilson E; Sadayappan, Sakthivel; Previs, Michael J; Warshaw, David M (2019. ) Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems.Proceedings of the National Academy of Sciences of the United States of America, , 116 (43 ) ,21882-21892 More Information

Song, Taejeong; Sadayappan, Sakthivel (2019. ) Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration.Journal of muscle research and cell motility, , More Information

Alam, Perwez; Haile, Bereket; Arif, Mohammed; Pandey, Raghav; Rokvic, Miso; Nieman, Michelle; Maliken, Bryan D; Paul, Arghya; Wang, Yi-Gang; Sadayappan, Sakthivel; Ahmed, Rafeeq P H; Kanisicak, Onur (2019. ) Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction.Journal of the American Heart Association, , 8 (15 ) ,e012089 More Information

Sadayappan, Sakthivel; Gilbert, Richard J (2019. ) The potential role of neddylation in pre- and postnatal cardiac remodeling.American journal of physiology. Heart and circulatory physiology, , 317 (2 ) ,H276-H278 More Information

Arif, Mohammed; Sadayappan, Sakthivel; Becker, Richard C; Martin, Lisa J; Urbina, Elaine M (2019. ) Epigenetic modification: a regulatory mechanism in essential hypertension.Hypertension research : official journal of the Japanese Society of Hypertension, , 42 (8 ) ,1099-1113 More Information

Manoharan, Palanikumar; Song, Taejeong; Radzyukevich, Tatiana L; Sadayappan, Sakthivel; Lingrel, Jerry B; Heiny, Judith A (2019. ) KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration.iScience, , 17 ,334-346 More Information

Tabish, Ali M; Arif, Mohammed; Song, Taejeong; Elbeck, Zaher; Becker, Richard C; Knöll, Ralph; Sadayappan, Sakthivel (2019. ) Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology, , 317 (1 ) ,H168-H180 More Information

McNamara, James W; Singh, Rohit R; Sadayappan, Sakthivel (2019. ) Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin.Proceedings of the National Academy of Sciences of the United States of America, , 116 (24 ) ,11731-11736 More Information

Goh, Qingnian; Song, Taejeong; Petrany, Michael J; Cramer, Alyssa Aw; Sun, Chengyi; Sadayappan, Sakthivel; Lee, Se-Jin; Millay, Douglas P (2019. ) Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle.eLife, , 8 , More Information

Boyer, Justin G; Prasad, Vikram; Song, Taejeong; Lee, Donghoon; Fu, Xing; Grimes, Kelly M; Sargent, Michelle A; Sadayappan, Sakthivel; Molkentin, Jeffery D (2019. ) ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.JCI insight, , 5 , More Information

Barefield, David Y; McNamara, James W; Lynch, Thomas L; Kuster, Diederik W D; Govindan, Suresh; Haar, Lauren; Wang, Yang; Taylor, Erik N; Lorenz, John N; Nieman, Michelle L; Zhu, Guangshuo; Luther, Pradeep K; Varró, Andras; Dobrev, Dobromir; Ai, Xun; Janssen, Paul M L; Kass, David A; Jones, Walter Keith; Gilbert, Richard J; Sadayappan, Sakthivel (2019. ) Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.Journal of molecular and cellular cardiology, , 129 ,236-246 More Information

Becker, Richard C; Cotarlan, Vlad; Sadayappan, Sakthi (2019. ) The rapid proliferation of solicited content online journals: a quest to disseminate knowledge?.Journal of thrombosis and thrombolysis, , 47 (3 ) ,337-344 More Information

Sadayappan, Sakthivel (2019. ) Cardiovascular Leaders Are Made, not Born.Circulation research, , 124 (4 ) ,484-487 More Information

O'Leary, Thomas S; Snyder, Julia; Sadayappan, Sakthivel; Day, Sharlene M; Previs, Michael J (2019. ) MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology, , 127 ,165-173 More Information

Song, Taejeong; Manoharan, Palanikumar; Millay, Douglas P; Koch, Sheryl E; Rubinstein, Jack; Heiny, Judith A; Sadayappan, Sakthivel (2019. ) Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.Skeletal muscle, , 9 (1 ) ,4 More Information

Toepfer, Christopher N; Wakimoto, Hiroko; Garfinkel, Amanda C; McDonough, Barbara; Liao, Dan; Jiang, Jianming; Tai, Angela C; Gorham, Joshua M; Lunde, Ida G; Lun, Mingyue; Lynch, Thomas L; McNamara, James W; Sadayappan, Sakthivel; Redwood, Charles S; Watkins, Hugh C; Seidman, Jonathan G; Seidman, Christine E (2019. ) Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.Science translational medicine, , 11 (476 ) , More Information

Ikeda, Shohei; Mizushima, Wataru; Sciarretta, Sebastiano; Abdellatif, Maha; Zhai, Peiyong; Mukai, Risa; Fefelova, Nadezhda; Oka, Shin-Ichi; Nakamura, Michinari; Del Re, Dominic P; Farrance, Iain; Park, Ji Yeon; Tian, Bin; Xie, Lai-Hua; Kumar, Mohit; Hsu, Chiao-Po; Sadayappan, Sakthivel; Shimokawa, Hiroaki; Lim, Dae-Sik; Sadoshima, Junichi (2019. ) Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.Circulation research, , 124 (2 ) ,292-305 More Information

McNamara, James W; Sadayappan, Sakthivel (2018. ) Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology.Archives of biochemistry and biophysics, , 660 ,121-128 More Information

McNamara, James W; Grimes, Kelly M; Sadayappan, Sakthivel (2018. ) Basic Cardiovascular Sciences Scientific Sessions 2018.Circulation research, , 123 (9 ) ,1024-1029 More Information

Viswanathan, Shiv Kumar; Puckelwartz, Megan J; Mehta, Ashish; Ramachandra, Chrishan J A; Jagadeesan, Aravindakshan; Fritsche-Danielson, Regina; Bhat, Ratan V; Wong, Philip; Kandoi, Sangeetha; Schwanekamp, Jennifer A; Kuffel, Gina; Pesce, Lorenzo L; Zilliox, Michael J; Durai, U Nalla B; Verma, Rama Shanker; Molokie, Robert E; Suresh, Domodhar P; Khoury, Philip R; Thomas, Annie; Sanagala, Thriveni; Tang, Hak Chiaw; Becker, Richard C; Knöll, Ralph; Shim, Winston; McNally, Elizabeth M; Sadayappan, Sakthivel (2018. ) Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3?25bpIntronic Deletion in South Asian Descendants.JAMA cardiology, , 3 (6 ) ,481-488 More Information

Smyrnias, Ioannis; Goodwin, Normann; Wachten, Dagmar; Skogestad, Jonas; Aronsen, Jan Magnus; Robinson, Emma L; Demydenko, Kateryna; Segonds-Pichon, Anne; Oxley, David; Sadayappan, Sakthivel; Sipido, Karin; Bootman, Martin D; Roderick, H Llewelyn (2018. ) Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes.Journal of molecular and cellular cardiology, , 117 ,1-18 More Information

Sadayappan, Sakthivel (2018. ) My Life, My Heart, and My(osin) Binding Protein-C.Circulation research, , 122 (7 ) ,918-920 More Information

Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang (2018. ) Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.Nature communications, , 9 (1 ) ,700 More Information

Lin, Brian Leei; Li, Amy; Mun, Ji Young; Previs, Michael J; Previs, Samantha Beck; Campbell, Stuart G; Dos Remedios, Cristobal G; Tombe, Pieter de P; Craig, Roger; Warshaw, David M; Sadayappan, Sakthivel (2018. ) Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner.Scientific reports, , 8 (1 ) ,2604 More Information

Hoffman, Matthew P; Taylor, Erik N; Aninwene, George E; Sadayappan, Sakthivel; Gilbert, Richard J (2018. ) Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review.Microscopy research and technique, , 81 (2 ) ,162-170 More Information

Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack (2018. ) Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.Journal of the American Heart Association, , 7 (2 ) , More Information

Arif, Mohammed; Pandey, Raghav; Alam, Perwez; Jiang, Shujia; Sadayappan, Sakthivel; Paul, Arghya; Ahmed, Rafeeq P H (2017. ) MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents.Journal of molecular medicine (Berlin, Germany), , 95 (12 ) ,1369-1385 More Information

Grimes, Kelly M; Barefield, David Y; Kumar, Mohit; McNamara, James W; Weintraub, Susan T; de Tombe, Pieter P; Sadayappan, Sakthivel; Buffenstein, Rochelle (2017. ) The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.Pflugers Archiv : European journal of physiology, , 469 (12 ) ,1603-1613 More Information

Viswanathan, Shiv Kumar; Sanders, Heather K; McNamara, James W; Jagadeesan, Aravindakshan; Jahangir, Arshad; Tajik, A Jamil; Sadayappan, Sakthivel (2017. ) Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage.PloS one, , 12 (11 ) ,e0187948 More Information

Tong, Carl W; Dusio, Giuseppina F; Govindan, Suresh; Johnson, Dustin W; Kidwell, David T; De La Rosa, Lisa M; Rosas, Paola C; Liu, Yang; Ebert, Elizabeth; Newell-Rogers, M Karen; Michel, Jeffrey B; Trzeciakowski, Jerome P; Sadayappan, Sakthivel (2017. ) Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events.The American journal of cardiology, , 120 (9 ) ,1501-1507 More Information

Sadayappan, Sakthivel (2017. ) The Myofilament Field Revisited in the Age of Cellular and Molecular Biology.Circulation research, , 121 (6 ) ,601-603 More Information

Sivaguru, Mayandi; Kabir, Mohammad M; Gartia, Manas Ranjan; Biggs, David S C; Sivaguru, Barghav S; Sivaguru, Vignesh A; Fried, Glenn A; Liu, Gang Logan; Sadayappan, Sakthivel; Toussaint, Kimani C (2017. ) Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy.Journal of microscopy, , 267 (3 ) ,397-408 More Information

Sadayappan, Sakthivel (2017. ) Cardiovascular Early Careers: Past and Present.Circulation research, , 121 (2 ) ,100-102 More Information

Lynch, Thomas L; Kuster, Diederik W D; Gonzalez, Beverly; Balasubramanian, Neelam; Nair, Nandini; Day, Sharlene; Calvino, Jenna E; Tan, Yanli; Liebetrau, Christoph; Troidl, Christian; Hamm, Christian W; Güçlü, Ahmet; McDonough, Barbara; Marian, Ali J; van der Velden, Jolanda; Seidman, Christine E; Huggins, Gordon S; Sadayappan, Sakthivel (2017. ) Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome.JACC. Basic to translational science, , 2 (2 ) ,122-131 More Information

Lin, Brian Leei; Song, Taejeong; Sadayappan, Sakthivel (2017. ) Myofilaments: Movers and Rulers of the Sarcomere.Comprehensive Physiology, , 7 (2 ) ,675-692 More Information

Lynch, Thomas L; Ismahil, Mohamed Ameen; Jegga, Anil G; Zilliox, Michael J; Troidl, Christian; Prabhu, Sumanth D; Sadayappan, Sakthivel (2017. ) Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.Journal of molecular and cellular cardiology, , 102 ,83-93 More Information

Barefield, David Y; Lynch, Thomas L; Jagadeesan, Aravindakshan; Sanagala, Thriveni; Sadayappan, Sakthivel (2016. ) High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant.Journal of molecular biomarkers & diagnosis, , 7 (6 ) , More Information

Kraker, Jessica; Viswanathan, Shiv Kumar; Knöll, Ralph; Sadayappan, Sakthivel (2016. ) Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants.Frontiers in physiology, , 7 ,499 More Information

Lipps, Christoph; Nguyen, Jenine H; Pyttel, Lukas; Lynch, Thomas L; Liebetrau, Christoph; Aleshcheva, Ganna; Voss, Sandra; Dörr, Oliver; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Sadayappan, Sakthivel; Troidl, Christian (2016. ) N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.Journal of molecular and cellular cardiology, , 99 ,47-56 More Information

Stathopoulou, Konstantina; Wittig, Ilka; Heidler, Juliana; Piasecki, Angelika; Richter, Florian; Diering, Simon; van der Velden, Jolanda; Buck, Friedrich; Donzelli, Sonia; Schröder, Ewald; Wijnker, Paul J M; Voigt, Niels; Dobrev, Dobromir; Sadayappan, Sakthivel; Eschenhagen, Thomas; Carrier, Lucie; Eaton, Philip; Cuello, Friederike (2016. ) S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 30 (5 ) ,1849-64 More Information

Taylor, Erik N; Hoffman, Matthew P; Barefield, David Y; Aninwene, George E; Abrishamchi, Aurash D; Lynch, Thomas L; Govindan, Suresh; Osinska, Hanna; Robbins, Jeffrey; Sadayappan, Sakthivel; Gilbert, Richard J (2016. ) Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C.Journal of the American Heart Association, , 5 (3 ) ,e002836 More Information

Kumar, Mohit; Govindan, Suresh; Zhang, Mengjie; Khairallah, Ramzi J; Martin, Jody L; Sadayappan, Sakthivel; de Tombe, Pieter P (2015. ) Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.The Journal of biological chemistry, , 290 (49 ) ,29241-9 More Information

Sivaguru, Mayandi; Fried, Glenn; Sivaguru, Barghav S; Sivaguru, Vignesh A; Lu, Xiaochen; Choi, Kyung Hwa; Saif, M Taher A; Lin, Brian; Sadayappan, Sakthivel (2015. ) Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy.BioTechniques, , 59 (5 ) ,295-308 More Information

Thoonen, Robrecht; Giovanni, Shewit; Govindan, Suresh; Lee, Dong I; Wang, Guang-Rong; Calamaras, Timothy D; Takimoto, Eiki; Kass, David A; Sadayappan, Sakthivel; Blanton, Robert M (2015. ) Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-I? Substrate.Circulation. Heart failure, , 8 (6 ) ,1115-22 More Information

Tong, Carl W; Wu, Xin; Liu, Yang; Rosas, Paola C; Sadayappan, Sakthivel; Hudmon, Andy; Muthuchamy, Mariappan; Powers, Patricia A; Valdivia, Héctor H; Moss, Richard L (2015. ) Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or ?1-Adrenergic Stimulation.Circulation. Heart failure, , 8 (3 ) ,595-604 More Information

Kuster, Diederik W D; Govindan, Suresh; Springer, Tzvia I; Martin, Jody L; Finley, Natosha L; Sadayappan, Sakthivel (2015. ) A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.The Journal of biological chemistry, , 290 (9 ) ,5855-67 More Information

Barefield, David; Kumar, Mohit; Gorham, Joshua; Seidman, Jonathan G; Seidman, Christine E; de Tombe, Pieter P; Sadayappan, Sakthivel (2015. ) Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Journal of molecular and cellular cardiology, , 79 ,234-43 More Information

Lee, Kyounghwan; Harris, Samantha P; Sadayappan, Sakthivel; Craig, Roger (2015. ) Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM.Journal of molecular biology, , 427 (2 ) ,274-86 More Information

Lynch, Thomas L; Sivaguru, Mayandi; Velayutham, Murugesan; Cardounel, Arturo J; Michels, Michelle; Barefield, David; Govindan, Suresh; dos Remedios, Cristobal; van der Velden, Jolanda; Sadayappan, Sakthivel (2015. ) Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.Oxidative medicine and cellular longevity, , 2015 ,424751 More Information

Wilson, Kristin; Guggilam, Anuradha; West, T Aaron; Zhang, Xiaojin; Trask, Aaron J; Cismowski, Mary J; de Tombe, Pieter; Sadayappan, Sakthivel; Lucchesi, Pamela A (2014. ) Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure.American journal of physiology. Heart and circulatory physiology, , 307 (11 ) ,H1605-17 More Information

Wang, Li; Sadayappan, Sakthivel; Kawai, Masakata (2014. ) Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner.PloS one, , 9 (11 ) ,e113417 More Information

Helms, Adam S; Davis, Frank M; Coleman, David; Bartolone, Sarah N; Glazier, Amelia A; Pagani, Francis; Yob, Jaime M; Sadayappan, Sakthivel; Pedersen, Ellen; Lyons, Robert; Westfall, Margaret V; Jones, Richard; Russell, Mark W; Day, Sharlene M (2014. ) Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy.Circulation. Cardiovascular genetics, , 7 (4 ) ,434-43 More Information

Lynch, Thomas L; Sadayappan, Sakthivel (2014. ) Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium.Proteomics. Clinical applications, , 8 (7-8 ) ,569-77 More Information

Haynes, Premi; Nava, Kristofer E; Lawson, Benjamin A; Chung, Charles S; Mitov, Mihail I; Campbell, Stuart G; Stromberg, Arnold J; Sadayappan, Sakthivel; Bonnell, Mark R; Hoopes, Charles W; Campbell, Kenneth S (2014. ) Transmural heterogeneity of cellular level power output is reduced in human heart failure.Journal of molecular and cellular cardiology, , 72 ,1-8 More Information

Hoffmann, Jedrzej; Ospelt, Manuel; Troidl, Christian; Voss, Sandra; Liebetrau, Christoph; Kim, Won-Keun; Rolf, Andreas; Wietelmann, Astrid; Braun, Thomas; Troidl, Kerstin; Sadayappan, Sakthivel; Barefield, David; Hamm, Christian; Nef, Holger; Möllmann, Helge (2014. ) Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction.PloS one, , 9 (6 ) ,e98456 More Information

Witayavanitkul, Namthip; Ait Mou, Younss; Kuster, Diederik W D; Khairallah, Ramzi J; Sarkey, Jason; Govindan, Suresh; Chen, Xin; Ge, Ying; Rajan, Sudarsan; Wieczorek, David F; Irving, Thomas; Westfall, Margaret V; de Tombe, Pieter P; Sadayappan, Sakthivel (2014. ) Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.The Journal of biological chemistry, , 289 (13 ) ,8818-27 More Information

Wang, Li; Ji, Xiang; Barefield, David; Sadayappan, Sakthivel; Kawai, Masakata (2014. ) Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner.Biophysical journal, , 106 (5 ) ,1112-22 More Information

Barefield, David; Kumar, Mohit; de Tombe, Pieter P; Sadayappan, Sakthivel (2014. ) Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.American journal of physiology. Heart and circulatory physiology, , 306 (6 ) ,H807-15 More Information

Kuster, Diederik W D; Cardenas-Ospina, Adriana; Miller, Lawson; Liebetrau, Christoph; Troidl, Christian; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Pieper, Karen S; Mahaffey, Kenneth W; Kleiman, Neal S; Stuyvers, Bruno D; Marian, Ali J; Sadayappan, Sakthivel (2014. ) Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury.American journal of physiology. Heart and circulatory physiology, , 306 (4 ) ,H547-56 More Information

Gao, Xianlong; Lin, Brian; Sadayappan, Sakthivel; Patel, Tarun B (2014. ) Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.Molecular pharmacology, , 85 (2 ) ,357-67 More Information

Kuster, Diederik W D; Sadayappan, Sakthivel (2014. ) MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation.Pflugers Archiv : European journal of physiology, , 466 (2 ) ,207-13 More Information

Sadayappan, Sakthivel; de Tombe, Pieter P (2014. ) Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.Pflugers Archiv : European journal of physiology, , 466 (2 ) ,195-200 More Information

Simon, Jillian N; Chowdhury, Shamim A K; Warren, Chad M; Sadayappan, Sakthivel; Wieczorek, David F; Solaro, R John; Wolska, Beata M (2014. ) Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation.Basic research in cardiology, , 109 (6 ) ,445 More Information

Khairallah, Ramzi J; Sadayappan, Sakthivel (2013. ) Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach.Proteomics, , 13 (22 ) ,3245-6 More Information

Guillory, Ashley N; Yin, Xing; Wijaya, Cori S; Diaz Diaz, Andrea C; Rababa'h, Abeer; Singh, Sonal; Atrooz, Fatin; Sadayappan, Sakthivel; McConnell, Bradley K (2013. ) Enhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade.PloS one, , 8 (9 ) ,e74784 More Information

Kuster, Diederik W D; Barefield, David; Govindan, Suresh; Sadayappan, Sakthivel (2013. ) A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay.Journal of visualized experiments : JoVE, , (78 ) , More Information

Lin, Brian; Govindan, Suresh; Lee, Kyounghwan; Zhao, Piming; Han, Renzhi; Runte, K Elisabeth; Craig, Roger; Palmer, Bradley M; Sadayappan, Sakthivel (2013. ) Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function.PloS one, , 8 (7 ) ,e69671 More Information

Jin, Chun Zi; Jang, Ji Hyun; Kim, Hae Jin; Wang, Yue; Hwang, In-Chang; Sadayappan, Sakthivel; Park, Byung Mun; Kim, Suhn Hee; Jin, Zhe Hu; Seo, Eun Yeong; Kim, Kyung-Hee; Kim, Yong-Jin; Kim, Sung Joon; Zhang, Yin Hua (2013. ) Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart.Journal of molecular and cellular cardiology, , 60 ,107-15 More Information

Govindan, Suresh; Kuster, Diederik Wd; Lin, Brian; Kahn, Daniel J; Jeske, Walter P; Walenga, Jeanine M; Leya, Fred; Hoppensteadt, Debra; Fareed, Jawed; Sadayappan, Sakthivel (2013. ) Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. American journal of cardiovascular disease, , 3 (2 ) ,60-70

Sequeira, Vasco; Wijnker, Paul J M; Nijenkamp, Louise L A M; Kuster, Diederik W D; Najafi, Aref; Witjas-Paalberends, E Rosalie; Regan, Jessica A; Boontje, Nicky; Ten Cate, Folkert J; Germans, Tjeerd; Carrier, Lucie; Sadayappan, Sakthivel; van Slegtenhorst, Marjon A; Zaremba, Ruud; Foster, D Brian; Murphy, Anne M; Poggesi, Corrado; Dos Remedios, Cris; Stienen, Ger J M; Ho, Carolyn Y; Michels, Michelle; van der Velden, Jolanda (2013. ) Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.Circulation research, , 112 (11 ) ,1491-505 More Information

Guggilam, Anuradha; Hutchinson, Kirk R; West, T Aaron; Kelly, Amy P; Galantowicz, Maarten L; Davidoff, Amy J; Sadayappan, Sakthivel; Lucchesi, Pamela A (2013. ) In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure.Journal of molecular and cellular cardiology, , 57 ,47-58 More Information

Kuster, Diederik W D; Sequeira, Vasco; Najafi, Aref; Boontje, Nicky M; Wijnker, Paul J M; Witjas-Paalberends, E Rosalie; Marston, Steven B; Dos Remedios, Cristobal G; Carrier, Lucie; Demmers, Jeroen A A; Redwood, Charles; Sadayappan, Sakthivel; van der Velden, Jolanda (2013. ) GSK3? phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.Circulation research, , 112 (4 ) ,633-9 More Information

Hwang, Hyosook; Robinson, Dustin; Rogers, Julie B; Stevenson, Tamara K; Lang, Sarah E; Sadayappan, Sakthivel; Day, Sharlene M; Sivaramakrishnan, Sivaraj; Westfall, Margaret V (2013. ) Agonist activated PKC?II translocation and modulation of cardiac myocyte contractile function.Scientific reports, , 3 ,1971 More Information

Hinken, Aaron C; Hanft, Laurin M; Scruggs, Sarah B; Sadayappan, Sakthivel; Robbins, Jeffery; Solaro, R John; McDonald, Kerry S (2012. ) Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A.Journal of muscle research and cell motility, , 33 (6 ) ,439-48 More Information

Dirkx, Ellen; Cazorla, Olivier; Schwenk, Robert W; Lorenzen-Schmidt, Ilka; Sadayappan, Sakthivel; Van Lint, Johan; Carrier, Lucie; van Eys, Guillaume J J M; Glatz, Jan F C; Luiken, Joost J F P (2012. ) Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.American journal of physiology. Heart and circulatory physiology, , 303 (3 ) ,H323-31 More Information

Hwang, Hyosook; Robinson, Dustin A; Stevenson, Tamara K; Wu, Helen C; Kampert, Sarah E; Pagani, Francis D; Dyke, D Brad; Martin, Jody L; Sadayappan, Sakthival; Day, Sharlene M; Westfall, Margaret V (2012. ) PKC?II modulation of myocyte contractile performance.Journal of molecular and cellular cardiology, , 53 (2 ) ,176-86 More Information

Verma, Suresh Kumar; Krishnamurthy, Prasanna; Barefield, David; Singh, Neha; Gupta, Rajesh; Lambers, Erin; Thal, Melissa; Mackie, Alexander; Hoxha, Eneda; Ramirez, Veronica; Qin, Gangjian; Sadayappan, Sakthivel; Ghosh, Asish K; Kishore, Raj (2012. ) Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B.Circulation, , 126 (4 ) ,418-29 More Information

Sadayappan, Sakthivel; de Tombe, Pieter P (2012. ) Cardiac myosin binding protein-C: redefining its structure and function.Biophysical reviews, , 4 (2 ) ,93-106 More Information

Govindan, Suresh; Sarkey, Jason; Ji, Xiang; Sundaresan, Nagalingam R; Gupta, Mahesh P; de Tombe, Pieter P; Sadayappan, Sakthivel (2012. ) Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.Journal of muscle research and cell motility, , 33 (1 ) ,17-30 More Information

Howarth, Jack W; Ramisetti, Srinivas; Nolan, Kristof; Sadayappan, Sakthivel; Rosevear, Paul R (2012. ) Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain.The Journal of biological chemistry, , 287 (11 ) ,8254-62 More Information

Sadayappan, Sakthivel (2012. ) Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury.Biomarkers in medicine, , 6 (1 ) ,69-72 More Information

van Dijk, Sabine J; Paalberends, E Rosalie; Najafi, Aref; Michels, Michelle; Sadayappan, Sakthivel; Carrier, Lucie; Boontje, Nicky M; Kuster, Diederik W D; van Slegtenhorst, Marjon; Dooijes, Dennis; dos Remedios, Cris; ten Cate, Folkert J; Stienen, Ger J M; van der Velden, Jolanda (2012. ) Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.Circulation. Heart failure, , 5 (1 ) ,36-46 More Information

Weith, Abbey; Sadayappan, Sakthivel; Gulick, James; Previs, Michael J; Vanburen, Peter; Robbins, Jeffrey; Warshaw, David M (2012. ) Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.Journal of molecular and cellular cardiology, , 52 (1 ) ,219-27 More Information

Govindan, Suresh; McElligott, Andrew; Muthusamy, Saminathan; Nair, Nandini; Barefield, David; Martin, Jody L; Gongora, Enrique; Greis, Kenneth D; Luther, Pradeep K; Winegrad, Saul; Henderson, Kyle K; Sadayappan, Sakthivel (2012. ) Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.Journal of molecular and cellular cardiology, , 52 (1 ) ,154-64 More Information

Palmer, Bradley M; Sadayappan, Sakthivel; Wang, Yuan; Weith, Abbey E; Previs, Michael J; Bekyarova, Tanya; Irving, Thomas C; Robbins, Jeffrey; Maughan, David W (2011. ) Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.Biophysical journal, , 101 (7 ) ,1661-9 More Information

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey (2011. ) A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.Circulation research, , 109 (2 ) ,141-50 More Information

Cuello, Friederike; Bardswell, Sonya C; Haworth, Robert S; Ehler, Elisabeth; Sadayappan, Sakthivel; Kentish, Jonathan C; Avkiran, Metin (2011. ) Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation.The Journal of biological chemistry, , 286 (7 ) ,5300-10 More Information

Copeland, O'Neal; Sadayappan, Sakthivel; Messer, Andrew E; Steinen, Ger J M; van der Velden, Jolanda; Marston, Steven B (2010. ) Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle.Journal of molecular and cellular cardiology, , 49 (6 ) ,1003-11 More Information

Senapathy, Periannan; Bhasi, Ashwini; Mattox, Jeffrey; Dhandapany, Perundurai S; Sadayappan, Sakthivel (2010. ) Targeted genome-wide enrichment of functional regions.PloS one, , 5 (6 ) ,e11138 More Information

Barefield, David; Sadayappan, Sakthivel (2010. ) Phosphorylation and function of cardiac myosin binding protein-C in health and disease.Journal of molecular and cellular cardiology, , 48 (5 ) ,866-75 More Information

Bardswell, Sonya C; Cuello, Friederike; Rowland, Alexandra J; Sadayappan, Sakthivel; Robbins, Jeffrey; Gautel, Mathias; Walker, Jeffery W; Kentish, Jonathan C; Avkiran, Metin (2010. ) Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling.The Journal of biological chemistry, , 285 (8 ) ,5674-82 More Information

Nicolaou, Persoulla; Rodriguez, Patricia; Ren, Xiaoping; Zhou, Xiaoyang; Qian, Jiang; Sadayappan, Sakthivel; Mitton, Bryan; Pathak, Anand; Robbins, Jeffrey; Hajjar, Roger J; Jones, Keith; Kranias, Evangelia G (2009. ) Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury.Circulation research, , 104 (8 ) ,1012-20 More Information

Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey (2009. ) Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.Circulation, , 119 (9 ) ,1253-62 More Information

Dhandapany, Perundurai S; Sadayappan, Sakthivel; Xue, Yali; Powell, Gareth T; Rani, Deepa Selvi; Nallari, Prathiba; Rai, Taranjit Singh; Khullar, Madhu; Soares, Pedro; Bahl, Ajay; Tharkan, Jagan Mohan; Vaideeswar, Pradeep; Rathinavel, Andiappan; Narasimhan, Calambur; Ayapati, Dharma Rakshak; Ayub, Qasim; Mehdi, S Qasim; Oppenheimer, Stephen; Richards, Martin B; Price, Alkes L; Patterson, Nick; Reich, David; Singh, Lalji; Tyler-Smith, Chris; Thangaraj, Kumarasamy (2009. ) A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.Nature genetics, , 41 (2 ) ,187-91 More Information

Sadayappan, Sakthivel; Finley, Natosha; Howarth, Jack W; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Rosevear, Paul R; Robbins, Jeffrey (2008. ) Role of the acidic N' region of cardiac troponin I in regulating myocardial function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 22 (4 ) ,1246-57 More Information

Sadayappan, Sakthivel; Robbins, Jeffrey (2008. ) The death of transcriptional chauvinism in the control and regulation of cardiac contractility.Annals of the New York Academy of Sciences, , 1123 ,1-9 More Information

Nagayama, Takahiro; Takimoto, Eiki; Sadayappan, Sakthivel; Mudd, James O; Seidman, J G; Robbins, Jeffrey; Kass, David A (2007. ) Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.Circulation, , 116 (21 ) ,2399-408 More Information

Dhandapany, Perundurai S; Sadayappan, Sakthivel; Vanniarajan, Ayyasamy; Karthikeyan, Bose; Nagaraj, Chandran; Gowrishankar, Kalpana; Selvam, Govindan Sadasivam; Singh, Lalji; Thangaraj, Kumarasamy (2007. ) Novel mitochondrial DNA mutations implicated in Noonan syndrome.International journal of cardiology, , 120 (2 ) ,284-5 More Information

Yasuda, So-ichiro; Coutu, Pierre; Sadayappan, Sakthivel; Robbins, Jeffrey; Metzger, Joseph M (2007. ) Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes.Circulation research, , 101 (4 ) ,377-86 More Information

Krenz, Maike; Sadayappan, Sakthivel; Osinska, Hanna E; Henry, Jeffrey A; Beck, Samantha; Warshaw, David M; Robbins, Jeffrey (2007. ) Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.The Journal of biological chemistry, , 282 (33 ) ,24057-64 More Information

Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2006. ) Cardiac myosin binding protein C phosphorylation is cardioprotective.Proceedings of the National Academy of Sciences of the United States of America, , 103 (45 ) ,16918-23 More Information

Wang, Hao; Grant, Jennifer E; Doede, Christopher M; Sadayappan, Sakthivel; Robbins, Jeffrey; Walker, Jeffery W (2006. ) PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144.Journal of molecular and cellular cardiology, , 41 (5 ) ,823-33 More Information

Annapoorani, Ponnambalam; Dhandapany, Perundurai S; Sadayappan, Sakthivel; Ramasamy, Subbiah; Rathinavel, Andiappan; Selvam, Govindan Sadasivam (2006. ) Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients.Atherosclerosis, , 186 (1 ) ,173-6 More Information

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Martin, Lisa A; Hahn, Harvey S; Dorn, Gerald W; Klevitsky, Raisa; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2005. ) Cardiac myosin-binding protein-C phosphorylation and cardiac function.Circulation research, , 97 (11 ) ,1156-63 More Information

Becker, Richard C; Sadayappan, Sakthivel (2020. ) Designing Human In Vitro Models for Drug Development.Journal of the American College of Cardiology, , 75 (6 ) ,587-589 More Information

Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J (2020. ) Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation.JACC. Basic to translational science, , 5 (2 ) ,109-122 More Information

Contact Information

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231 Albert Sabin Way
Cincinnati  Ohio, 45267-0542
Phone: 513-558-7498
Fax: 513-558-2884
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