Shailendra Patel

Shailendra B Patel , PhD

Professor

Division Director; Albert W. Vontz, Jr. Professorship of Diabetes

231 Albert Sabin Way
Cincinnati, Ohio 45267-0547
Phone 513-558-4444
Fax 513-558-8581

Education

Bachelor's Degree: Oxford University Oxford, UK, 1979 (Physiological Sciences)

Doctoral Degree: Oxford University Oxford, UK, 1982

Bachelor's Degree: Oxford University Oxford, UK, 1985

House Officer : Western General Hospital Edinburgh, Scotland, 1986 (Neurosurgery)

House Officer : Torquay Hospital Torquay, England, UK, 1986 (Internal Medicine)

Senior House Officer : Freeman and Newcastle General Hospitals Newcastle, England, UK, 1988 (Internal Medicine)

Registrar: Northwick Park Hospital England, UK, 1989 (Endocrinology and Internal Medicine)

Senior Registrar: Northwick Park Hospital, Harrow, and Royal Postgraduate Medical School London, UK, 1993 (Metabolic and Molecular Medicine)

Fellowship: University of Texas Southwestern Medical Center Dallas, Texas, 1997 (Endocrinology)

Certifications

American Board of Internal Medicine (Endocrinology-Diabetes and Metabolism) (Certification Date: 11-03-2004 ) - (Recertification Date: to 09-09-2014 )

American Board of Internal Medicine (Certification Date: 08-19-2003 ) - (Recertification Date: to 10-22-2013 )

Clinical Interests

Endocrinology

Adrenal Disorders

Adrenal Dysfusion

Adrenal Gland Cancers

Adrenal Gland Disease

Adrenal Gland Suppression

Adrenal Gland Tumors (Pheochromocytoma)

Adrenal Insufficiency

Adrenal Nodules

Adrenal Rest Tumor

Adrenal Tumors

Adrenocortical Adenoma

Adrenocortical Carcinoma

Adrenoleukodystrophy

Aldosteronoma

Arcus Senilis

Benign adrenal tumors

Cerebrotendnous Xanthomatosis

Congenital Adrenal Hyperplasia (CAH)

Conn's Syndrome (Primary aldosteronism)

Craniopharyngioma

Cushing syndrome (Hypercortisolism)

Early Puberty (Precocious puberty)

Empty Sella Syndrome

Familial Hypercholesterolemia

Gender Identity disorder (Gender dysphoria)

Glucagonoma

Glycogen Storage Disease Type VII

Growth Hormone Deficiency

Growth Hormone Excess (Acromegaly)

Growth Hormone-Secreting Pituitary Adenoma

High Cholesterol (Hypercholesterolemia)

Hyperaldosteronism

Hyperpituitarism

Hyponatremia

Inherited Metabolic Disorders

Insulinoma

Islet Cell Adenoma

Kallmann Syndrome

Klinefelter syndrome

Medullary Carcinoma

Medullary Thyroid Cancer

Multiple Endocrine Neoplasia

Multiple Endocrine Neoplasia I and II (MEN I and MEN II)

Multiple Endocrine Neoplasia Type 1 (Werner Syndrome)

Multiple Endocrine Neoplasia Type 2a

Multiple Endocrine Neoplasia Type 2b

Nelson Syndrome

Neuroendocrine Carcinoma

Neuroendocrine Tumors

Neurogenic Diabetes Insipidus

Nonfunctioning Pituitary Adenoma

Osteitis Fibrosa Cystica

Pancreas Neuroendocrine Tumors

Pancreatic Neuroendocrine Tumor

Paraganglioma

Pituitary Disease

Pituitary Disorders

Pituitary Dysfunction

Pituitary Insufficiency (Hypopituitarism)

Pituitary Tumor

POEMS Syndrome

Porphyria

Porphyria Cutanea Tarda

Porphyrias

Prolactinoma

Sitosterolemia

Smith-Lemli-Opitz Syndrome

Wolfram Syndrome

Hypopituitarism

Specialities

Endocrinology-Diabetes and Metabolism

Internal Medicine

Research and Practice Interests

Biological Effects of Xenosterols On The Mammalian Body
The normal human diet consists not only of cholesterol, but also xenosterols, such as plant sterols, but the mammalian body uses a number of different mechanisms to protect itself against the entry and effect of dietary xenosterols. One of these mechanisms was identified by us when we elucidated the gene defect causing the human disorder of sitosterolemia. Our current research now focuses on how xenosterols affect mammalian metabolism, ranging from their effects on adipose tissue, arterial wall and platelet development. This research uses animal models, as well as clinical studies. These studies have involved humans genetic mapping, and positional cloning, clinical studies aimed at defining the physiological defects, as well as development of knockout and transgenic mouse models to identify the underlying mechanisms. In addition, we also identified a commonly used rat model, SHR, that also has defects in xenosterol trafficking and have created a congenic rat model to study the pathophysiology. We have created mouse models that lack Abcg8, as well as Abcg5, we have developed special diets to restrict or control xenosterol intakes and made congenic rats that carry a mutant Abcg5 allele on the SD background and a wild-type Abcg5 allele on the SHR background (the SHR has a natural mutation in the Abcg5 gene).

Research Support

Grant: #UN16-00269 Investigators:Patel, Shailendra 06-01-2016 -05-31-2017 Greater Cincinnati Foundation Identifying novel drug targets for Obesity and Metabolic Diseases Role:PI $55,000.00 Awarded Level:Private Non-Profit

Grant: #R03AG063322 Investigators:Patel, Shailendra 04-01-2019 -01-31-2021 National Institute on Aging The Role of Abcg4 in Alzheimer’s Disease Role:PI $160,375.00 Awarded Level:Federal

Grant: #CHMC / 304617 /R03HD094882 Investigators:Patel, Shailendra 09-01-2018 -08-31-2020 National Institute of Child Health and Human Development Role of Cholesterol Biosynthesis in Development Role:PI $71,848.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Wang, Helen H; Li, Xiaodan; Patel, Shailendra B; Wang, David Q-H (2016. ) Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice.Hepatology (Baltimore, Md.), , 64 (3 ) ,853-64 More Information

Lange, Philip T; Darrah, Eric J; Vonderhaar, Emily P; Mboko, Wadzanai P; Rekow, Michaela M; Patel, Shailendra B; Sidjanin, Duska J; Tarakanova, Vera L (2016. ) Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection.Journal of virology, , 90 (7 ) ,3342-54 More Information

Appadurai, Vivek; DeBarber, Andrea; Chiang, Pei-Wen; Patel, Shailendra B; Steiner, Robert D; Tyler, Charles; Bonnen, Penelope E (2015. ) Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes.Molecular genetics and metabolism, , 116 (4 ) ,298-304 More Information

Nghiem-Rao, T Hang; Tunc, Ilker; Mavis, Alisha M; Cao, Yumei; Polzin, Elizabeth M; Firary, Mary F; Wang, Xujing; Simpson, Pippa M; Patel, Shailendra B (2015. ) Kinetics of phytosterol metabolism in neonates receiving parenteral nutrition.Pediatric research, , 78 (2 ) ,181-9 More Information

Weingärtner, Oliver; Teupser, Daniel; Patel, Shailendra B The Atherogenicity of Plant Sterols: The Evidence from Genetics to Clinical Trials.Journal of AOAC International, , 98 (3 ) ,742-9 More Information

Jialal, Ishwarlal; Patel, Shailendra B (2015. ) PCSK9 inhibitors: the next frontier in low-density lipoprotein lowering.Metabolic syndrome and related disorders, , 13 (3 ) ,99-101 More Information

Weingärtner, Oliver; Lütjohann, Dieter; Patel, Shailendra B (2015. ) Mutations in NPC1L1 and coronary heart disease.The New England journal of medicine, , 372 (9 ) ,881-2 More Information

Altemus, Jessica B; Patel, Shailendra B; Sehayek, Ephraim (2014. ) Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment.Metabolism: clinical and experimental, , 63 (10 ) ,1334-41 More Information

Mboko, Wadzanai P; Mounce, Bryan C; Emmer, Joseph; Darrah, Eric; Patel, Shailendra B; Tarakanova, Vera L (2014. ) Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells.Journal of virology, , 88 (12 ) ,6993-7004 More Information

Kanaji, Taisuke; Kanaji, Sachiko; Montgomery, Robert R; Patel, Shailendra B; Newman, Peter J (2013. ) Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia.Blood, , 122 (15 ) ,2732-42 More Information

Solca, Curzio; Tint, G Stephen; Patel, Shailendra B (2013. ) Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice.Journal of lipid research, , 54 (2 ) ,397-409 More Information

Solcà, Curzio; Pandit, Bhaswati; Yu, Hongwei; Tint, G Stephen; Patel, Shailendra B (2007. ) Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse.Molecular genetics and metabolism, , 91 (1 ) ,7-14 More Information

Kidambi, Srividya; Ghosh, Soumitra; Kotchen, Jane M; Grim, Clarence E; Krishnaswami, Shanthi; Kaldunski, Mary L; Cowley, Allen W; Patel, Shailendra B; Kotchen, Theodore A (2012. ) Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans.BMC medical genetics, , 13 ,27 More Information

Chen, JianLiang; Nittala, Aparna; Gao, Shouguo; Ghosh, Soumitra; Wang, Xujing; Patel, Shailendra Kinetics of insulin secretion to acute, repetitive stimulation of islets in vivo in Sprague Dawley rats.Islets, , 2 (1 ) ,10-7 More Information

Matabosch, Xavier; Rahman, Mahbuba; Hughes, Beverly; Patel, Shailendra B; Watson, Gordon; Shackleton, Cedric (2009. ) Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome.The Journal of steroid biochemistry and molecular biology, , 116 (1-2 ) ,61-70 More Information

Alcalay, Roy; Wu, Stacy; Patel, Shailendra; Frucht, Steven (2009. ) Oromandibular dystonia as a complication of cerebrotendinous xanthomatosis.Movement disorders : official journal of the Movement Disorder Society, , 24 (9 ) ,1397-9 More Information

Kidambi, S; Patel, S B (2008. ) Sitosterolaemia: pathophysiology, clinical presentation and laboratory diagnosis.Journal of clinical pathology, , 61 (5 ) ,588-94 More Information

Yu, Hongwei; Wakim, Bassam; Li, Man; Halligan, Brian; Tint, G Stephen; Patel, Shailendra B (2007. ) Quantifying raft proteins in neonatal mouse brain by 'tube-gel' protein digestion label-free shotgun proteomics.Proteome science, , 5 ,17 More Information

Yu, Hongwei; Li, Man; Tint, G Stephen; Chen, Jianliang; Xu, Guorong; Patel, Shailendra B (2007. ) Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice.BMC developmental biology, , 7 ,27 More Information

Wang, Helen H; Patel, Shailendra B; Carey, Martin C; Wang, David Q-H (2007. ) Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice.Hepatology (Baltimore, Md.), , 45 (4 ) ,998-1006 More Information

Pandit, Bhaswati; Ahn, Gwang-Sook; Hazard, Starr E; Gordon, Derek; Patel, Shailendra B (2006. ) A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans.BMC medical genetics, , 7 ,13 More Information

Yu, Hongwei; Pandit, Bhaswati; Klett, Eric; Lee, Mi-Hye; Lu, Kangmo; Helou, Khalil; Ikeda, Ikuo; Egashira, Nami; Sato, Masao; Klein, Richard; Batta, Ashok; Salen, Gerald; Patel, Shailendra B (2003. ) The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats.BMC cardiovascular disorders, , 3 ,4 More Information

Konersman, Chamindra G; Freyermuth, Fernande; Winder, Thomas L; Lawlor, Michael W; Lagier-Tourenne, Clotilde; Patel, Shailendra B (2017. ) Novel autosomal dominant TNNT1 mutation causing nemaline myopathy.Molecular genetics & genomic medicine, , 5 (6 ) ,678-691 More Information

Dodacki, Agnès; Wortman, Matthew; Saubaméa, Bruno; Chasseigneaux, Stéphanie; Nicolic, Sophie; Prince, Nathalie; Lochus, Murielle; Raveu, Anne-Laure; Declèves, Xavier; Scherrmann, Jean-Michel; Patel, Shailendra B; Bourasset, Fanchon (2017. ) Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-? peptide.Scientific reports, , 7 (1 ) ,13393 More Information

Bazerbachi, Fateh; Conboy, Erin E; Mounajjed, Taofic; Watt, Kymberly D; Babovic-Vuksanovic, Dusica; Patel, Shailendra B; Kamath, Patrick S (2017. ) Cryptogenic Cirrhosis and Sitosterolemia: A Treatable Disease If Identified but Fatal If Missed.Annals of hepatology, , 16 (6 ) ,970-978 More Information

Nghiem-Rao, T Hang; Dahlgren, Allison F; Kalluri, Deepti; Cao, Yumei; Simpson, Pippa M; Patel, Shailendra B Influence of gestational age and birth weight in neonatal cholesterol response to total parenteral nutrition.Journal of clinical lipidology, , 10 (4 ) ,891-897.e1 More Information

Patel, Shailendra B; Graf, Gregory; Temel, Ryan (2018. ) ABCG5 and ABCG8: More than a defense against xenosterols.Journal of lipid research, , More Information

Nghiem-Rao, T Hang; Patel, Shailendra B (2013. ) Investigating Sitosterolemia to Understand Lipid Physiology. Clinical lipidology, , 8 (3 ) ,649-658

Patel, Shailendra B (2015. ) Mendel, molecular biology, and apolipoprotein C-III: a heady combination.Metabolic syndrome and related disorders, , 13 (2 ) ,55-6 More Information

Patel, Shailendra B (2014. ) Recent advances in understanding the STSL locus and ABCG5/ABCG8 biology.Current opinion in lipidology, , 25 (3 ) ,169-75 More Information

Patel, Shailendra B (2011. ) Location, location, location...again.Journal of lipid research, , 52 (3 ) ,417-8 More Information

Patel, Shailendra B; Steiner, Robert D (2010. ) In Memoriam: William E. Connor (1921-2009). Journal of lipid research, , 51 (4 ) ,679-81

Kidambi, Srividya; Patel, Shailendra B (2008. ) Diabetes mellitus: considerations for dentistry. Journal of the American Dental Association (1939), , 139 Suppl ,8S-18S

Patel, Shailendra B (2008. ) Closing comment.Journal of clinical lipidology, , 2 (4 ) ,308 More Information

Patel, Shailendra B (2008. ) Counterpoint: Sorting wheat from chaff.Journal of clinical lipidology, , 2 (4 ) ,306-7 More Information

Kidambi, S; Patel, S B (2008. ) Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: a review.Xenobiotica; the fate of foreign compounds in biological systems, , 38 (7-8 ) ,1119-39 More Information

Patel, Shailendra B (2008. ) Plant sterols and stanols: their role in health and disease.Journal of clinical lipidology, , 2 (2 ) ,S11-9 More Information

Hazard, Starr E; Patel, Shailendra B (2007. ) Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.Pflugers Archiv : European journal of physiology, , 453 (5 ) ,745-52 More Information

Kosters, Astrid; Kunne, Cindy; Looije, Norbert; Patel, Shailendra B; Oude Elferink, Ronald P J; Groen, Albert K (2006. ) The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.Journal of lipid research, , 47 (9 ) ,1959-66 More Information

Tint, G S; Yu, Hongwei; Shang, Quan; Xu, Guorong; Patel, Shailendra B (2006. ) The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.Journal of lipid research, , 47 (7 ) ,1535-41 More Information

Salen, Gerald; Starc, Thomas; Sisk, Christine McCrary; Patel, Shailendra B (2006. ) Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis.Gastroenterology, , 130 (6 ) ,1853-7 More Information

Miettinen, Tatu A; Klett, Eric L; Gylling, Helena; Isoniemi, Helena; Patel, Shailendra B (2006. ) Liver transplantation in a patient with sitosterolemia and cirrhosis.Gastroenterology, , 130 (2 ) ,542-7 More Information

Yu, H; Patel, S B (2005. ) Recent insights into the Smith-Lemli-Opitz syndrome.Clinical genetics, , 68 (5 ) ,383-91 More Information

Solcà, C; Stanga, Z; Pandit, B; Diem, P; Greeve, J; Patel, S B (2005. ) Sitosterolaemia in Switzerland: molecular genetics links the US Amish-Mennonites to their European roots.Clinical genetics, , 68 (2 ) ,174-8 More Information

Chen, Jianliang; Batta, Ashok; Zheng, Shuqin; Fitzgibbon, Wayne R; Ullian, Michael E; Yu, Hongwei; Tso, Patrick; Salen, Gerald; Patel, Shailendra B (2005. ) The missense mutation in Abcg5 gene in spontaneously hypertensive rats (SHR) segregates with phytosterolemia but not hypertension.BMC genetics, , 6 ,40 More Information

Yu, Hongwei; Wessels, Andy; Tint, G Stephen; Patel, Shailendra B (2005. ) Partial rescue of neonatal lethality of Dhcr7 null mice by a nestin promoter-driven DHCR7 transgene expression.Brain research. Developmental brain research, , 156 (1 ) ,46-60 More Information

Kosters, Astrid; Frijters, Raoul J J M; Kunne, Cindy; Vink, Edwin; Schneiders, Marit S; Schaap, Frank G; Nibbering, Catherina P; Patel, Shailendra B; Groen, Albert K (2005. ) Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.Hepatology (Baltimore, Md.), , 41 (1 ) ,141-50 More Information

Patel, Shailendra B (2004. ) Ezetimibe: a novel cholesterol-lowering agent that highlights novel physiologic pathways. Current cardiology reports, , 6 (6 ) ,439-42

Klett, Eric L; Lee, Mi-Hye; Adams, David B; Chavin, Kenneth D; Patel, Shailendra B (2004. ) Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine.BMC gastroenterology, , 4 ,21 More Information

Gordon, Derek; Haynes, Chad; Johnnidis, Christopher; Patel, Shailendra B; Bowcock, Anne M; Ott, Jürg (2004. ) A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents.European journal of human genetics : EJHG, , 12 (9 ) ,752-61 More Information

Gupta, Ram P; Hollis, Bruce W; Patel, Shailendra B; Patrick, Kennerly S; Bell, Norman H (2004. ) CYP3A4 is a human microsomal vitamin D 25-hydroxylase.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , 19 (4 ) ,680-8 More Information

Klett, Eric L; Lu, Kangmo; Kosters, Astrid; Vink, Edwin; Lee, Mi-Hye; Altenburg, Michael; Shefer, Sarah; Batta, Ashok K; Yu, Hongwei; Chen, Jianliang; Klein, Richard; Looije, Norbert; Oude-Elferink, Ronald; Groen, Albert K; Maeda, Nobuyo; Salen, Gerald; Patel, Shailendra B (2004. ) A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.BMC medicine, , 2 ,5 More Information

Salen, G; von Bergmann, K; Lütjohann, D; Kwiterovich, P; Kane, J; Patel, S B; Musliner, T; Stein, P; Musser, B (2004. ) Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia.Circulation, , 109 (8 ) ,966-71 More Information

Klett, Eric L; Patel, Shailesh B (2004. ) Biomedicine. Will the real cholesterol transporter please stand up.Science (New York, N.Y.), , 303 (5661 ) ,1149-50 More Information

Yu, Hongwei; Wessels, Andy; Chen, Jianliang; Phelps, Aimee L; Oatis, John; Tint, G Stephen; Patel, Shailendra B (2004. ) Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome.BMC developmental biology, , 4 ,1 More Information

Lu, Kangmo; Lee, Mi-Hye; Yu, Hongwei; Zhou, Yuehua; Sandell, Shelley A; Salen, Gerald; Patel, Shailendra B (2002. ) Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. Journal of lipid research, , 43 (4 ) ,565-78

Fitzky, B U; Moebius, F F; Asaoka, H; Waage-Baudet, H; Xu, L; Xu, G; Maeda, N; Kluckman, K; Hiller, S; Yu, H; Batta, A K; Shefer, S; Chen, T; Salen, G; Sulik, K; Simoni, R D; Ness, G C; Glossmann, H; Patel, S B; Tint, G S (2001. ) 7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome.The Journal of clinical investigation, , 108 (6 ) ,905-15 More Information

Lu, K; Lee, M H; Patel, S B (2001. ) Dietary cholesterol absorption; more than just bile. Trends in endocrinology and metabolism: TEM, , 12 (7 ) ,314-20

Lu, K; Lee, M H; Hazard, S; Brooks-Wilson, A; Hidaka, H; Kojima, H; Ose, L; Stalenhoef, A F; Mietinnen, T; Bjorkhem, I; Bruckert, E; Pandya, A; Brewer , H B; Salen, G; Dean, M; Srivastava, A; Patel, S B (2001. ) Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. American journal of human genetics, , 69 (2 ) ,278-90

Lee, M H; Gordon, D; Ott, J; Lu, K; Ose, L; Miettinen, T; Gylling, H; Stalenhoef, A F; Pandya, A; Hidaka, H; Brewer, B; Kojima, H; Sakuma, N; Pegoraro, R; Salen, G; Patel, S B (2001. ) Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities.European journal of human genetics : EJHG, , 9 (5 ) ,375-84 More Information

Lu, K; Lee, M H; Carpten, J D; Sekhon, M; Patel, S B (2001. ) High-resolution physical and transcript map of human chromosome 2p21 containing the sitosterolaemia locus.European journal of human genetics : EJHG, , 9 (5 ) ,364-74 More Information

Lee, M H; Lu, K; Patel, S B (2001. ) Genetic basis of sitosterolemia. Current opinion in lipidology, , 12 (2 ) ,141-9

Lee, M H; Hazard, S; Carpten, J D; Yi, S; Cohen, J; Gerhardt, G T; Salen, G; Patel, S B (2001. ) Fine-mapping, mutation analyses, and structural mapping of cerebrotendinous xanthomatosis in U.S. pedigrees. Journal of lipid research, , 42 (2 ) ,159-69

Lee, M H; Lu, K; Hazard, S; Yu, H; Shulenin, S; Hidaka, H; Kojima, H; Allikmets, R; Sakuma, N; Pegoraro, R; Srivastava, A K; Salen, G; Dean, M; Patel, S B (2001. ) Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.Nature genetics, , 27 (1 ) ,79-83 More Information

Yu, H; Lee, M H; Starck, L; Elias, E R; Irons, M; Salen, G; Patel, S B; Tint, G S (2000. ) Spectrum of Delta(7)-dehydrocholesterol reductase mutations in patients with the Smith-Lemli-Opitz (RSH) syndrome. Human molecular genetics, , 9 (9 ) ,1385-91

Shelton, J M; Lee, M H; Richardson, J A; Patel, S B (2000. ) Microsomal triglyceride transfer protein expression during mouse development. Journal of lipid research, , 41 (4 ) ,532-7

Yu, H; Tint, G S; Salen, G; Patel, S B (2000. ) Detection of a common mutation in the RSH or Smith-Lemli-Opitz syndrome by a PCR-RFLP assay: IVS8-G-->C is found in over sixty percent of US propositi. American journal of medical genetics, , 90 (4 ) ,347-50

Wu, J; Zhu, Y H; Patel, S B (1999. ) Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. The American journal of physiology, , 277 (6 Pt 1 ) ,E1087-94

Garg, A; Wilson, R; Barnes, R; Arioglu, E; Zaidi, Z; Gurakan, F; Kocak, N; O'Rahilly, S; Taylor, S I; Patel, S B; Bowcock, A M (1999. ) A gene for congenital generalized lipodystrophy maps to human chromosome 9q34.The Journal of clinical endocrinology and metabolism, , 84 (9 ) ,3390-4 More Information

Patel, S B; Salen, G; Hidaka, H; Kwiterovich, P O; Stalenhoef, A F; Miettinen, T A; Grundy, S M; Lee, M H; Rubenstein, J S; Polymeropoulos, M H; Brownstein, M J (1998. ) Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.The Journal of clinical investigation, , 102 (5 ) ,1041-4 More Information

Patel, S B; Honda, A; Salen, G (1998. ) Sitosterolemia: exclusion of genes involved in reduced cholesterol biosynthesis. Journal of lipid research, , 39 (5 ) ,1055-61

Berger, G M; Pegoraro, R J; Patel, S B; Naidu, P; Rom, L; Hidaka, H; Marais, A D; Jadhav, A; Naoumova, R P; Thompson, G R (1998. ) HMG-CoA reductase is not the site of the primary defect in phytosterolemia. Journal of lipid research, , 39 (5 ) ,1046-54

Nemeth-Slany, A; Talmud, P; Grundy, S M; Patel, S B (1997. ) Activation of a cryptic splice-site in intron 24 leads to the formation of apolipoprotein B-27.6. Atherosclerosis, , 133 (2 ) ,163-70

Li, X; Grundy, S M; Patel, S B (1997. ) Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. Journal of lipid research, , 38 (7 ) ,1277-88

Patel, S B; Grundy, S M (1996. ) Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system. The Journal of biological chemistry, , 271 (31 ) ,18686-94

Patel, S B; Grundy, S M (1995. ) Heterologous expression of apolipoprotein B carboxyl-terminal truncates: a model for the study of lipoprotein biogenesis. Journal of lipid research, , 36 (10 ) ,2090-103

Patel, S B; Mahler, R (1990. ) Clostridial pleuropulmonary infections: case report and review of the literature. The Journal of infection, , 21 (1 ) ,81-5

Jackson, D A; Cook, P R; Patel, S B (1984. ) Attachment of repeated sequences to the nuclear cage. Nucleic acids research, , 12 (17 ) ,6709-26

Patel, S B; Cook, P R (1983. ) The DNA-protein cross: a method for detecting specific DNA-protein complexes in crude mixtures. The EMBO journal, , 2 (1 ) ,137-42

Kidambi, Srividya; Ghosh, Soumitra; Kotchen, Jane M; Grim, Clarence E; Krishnaswami, Shanthi; Kaldunski, Mary L; Cowley, Allen W; Patel, Shailendra B; Kotchen, Theodore A (2012. ) Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans.BMC medical genetics, , 13 ,27 More Information

Weingärtner, Oliver; Patel, Shailesh B; Lütjohann, Dieter (2020. ) It's time to personalize and optimize lipid-lowering therapy.European heart journal, , 41 (28 ) ,2629-2631 More Information

Fong, Vincent; Patel, Shailendra B (2020. ) Recent advances in ABCG5 and ABCG8 variants.Current opinion in lipidology, , Publish Ahead of Print , More Information

Kanuri, Babunageswararao; Fong, Vincent; Haller, April; Hui, David Y; Patel, Shailendra B (2020. ) Mice lacking global Stap1 expression do not manifest hypercholesterolemia.BMC medical genetics, , 21 (1 ) ,234 More Information

Kanuri, Babunageswararao; Fong, Vincent; Ponny, Sithara Raju; Tallman, Keri A; Rao, Sriganesh Ramachandra; Porter, Ned; Fliesler, Steven J; Patel, Shailendra B (2020. ) Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome.Journal of lipid research, , 62 ,100002 More Information

Kanuri, Babunageswararao; Fong, Vincent; Ponny, Sithara Raju; Tallman, Keri A; Ramachandra Rao, Sriganesh; Porter, Ned A; Fliesler, Steven J; Patel, Shailendra B (2020. ) Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz Syndrome.Journal of lipid research, , More Information

Patel, Shailendra B; Tint, G Stephen; Honda, Akira; Grundy, Scott M (2021. ) In memoriam: Gerald (Gerry) Salen, MD (1935-2020).Journal of lipid research, , 62 ,100032 More Information

Kanuri, Babunageswararao; Fong, Vincent; Ponny, Sithara Raju; Weerasekera, Ranjuna; Pulakanti, Kirthi; Patel, Kriya S; Tyshynsky, Roman; Patel, Shailendra B (2021. ) Generation and validation of a conditional knockout mouse model for desmosterolosis.Journal of lipid research, , 62 ,100028 More Information

Nghiem-Rao, T Hang; Pfeifer, Courtney; Asuncion, Michelle; Nord, Joshua; Schill, Daniel; Pulakanti, Kirthi; Patel, Shailendra B; Cirillo, Lisa A; Rao, Sridhar (2021. ) Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver.Scientific reports, , 11 (1 ) ,12386 More Information

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