Tom Conrad Maugans Seegar, PhD

I am broadly interested in understanding how cells communicate and interpret the extracellular environment in normal and pathological conditions. In particular, I aim to investigate the universal concepts that underpin the function of membrane tethered proteases, such as the molecular basis for substrate selectivity, association with accessory proteins and regulation.

Lab Website: www.seegarlab.com

Ph.D.: Virginia Commonwealth University Richmond, Virginia, 2010

Post-Doc: Harvard Medical School Boston, Massachussets, 2020

Post-Doc: Massachusetts Institute of Technology Cambridge, MA, 2013

Seegar Lab Website

- Post-Doc, Harvard University, Boston, Massachussets

Grant: #R35GM146830- (MIRA) Investigators:Seegar, Tom 08-01-2022 -05-31-2027 National Institute of General Medical Sciences Structure and Regulation of Ectodomain Sheddases in Development and Disease Role:PI 405000.00 Awarded Level:Federal

Peer Reviewed Publications

Susa, Katherine J; Seegar, Tom CM; Blacklow, Stephen C; Kruse, Andrew C  (2020). A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. eLife, 9More Information

Adhikari, Arijit A; Seegar, Tom C M; Ficarro, Scott B; McCurry, Megan D; Ramachandran, Deepti; Yao, Lina; Chaudhari, Snehal N; Ndousse-Fetter, Sula; Banks, Alexander S; Marto, Jarrod A; Blacklow, Stephen C; Devlin, A Sloan  (2020). Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nature chemical biology, 16 (3) , 318-326More Information

Seegar, Tom CM; Blacklow, Stephen C  (2019). Domain integration of ADAM family proteins: Emerging themes from structural studies. Experimental biology and medicine (Maywood, N.J.), 244 (17) , 1510-1519More Information

Jarrett, Sanchez M; Seegar, Tom C M; Andrews, Mark; Adelmant, Guillaume; Marto, Jarrod A; Aster, Jon C; Blacklow, Stephen C  (2019). Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Science signaling, 12 (606) More Information

Rogers, Julia M; Waters, Colin T; Seegar, Tom C M; Jarrett, Sanchez M; Hallworth, Amelia N; Blacklow, Stephen C; Bulyk, Martha L  (2019). Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Molecular cell, 74 (2) , 245-253.e6More Information

Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu; Meyer, Peter A; Patra, Dhabaleswar; Zimmerman, Brandon; Janes, Peter W; Rubinstein, Eric; Nikolov, Dimitar B; Skiniotis, Georgios; Kruse, Andrew C; Blacklow, Stephen C  (2017). Structural Basis for Regulated Proteolysis by the ?-Secretase ADAM10. Cell, 171 (7) , 1638-1648.e7More Information

McMillan, Brian J; Tibbe, Christine; Drabek, Andrew A; Seegar, Tom C M; Blacklow, Stephen C; Klein, Thomas  (2017). Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell reports, 19 (9) , 1750-1757More Information

Zimmerman, Brandon; Kelly, Brendan; McMillan, Brian J; Seegar, Tom C M; Dror, Ron O; Kruse, Andrew C; Blacklow, Stephen C  (2016). Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167 (4) , 1041-1051.e11More Information

Lipper, Colin H; Gabriel, Khal-Hentz; Seegar, Tom C M; Dürr, Katharina L; Tomlinson, Michael G; Blacklow, Stephen C  (2022). Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure (London, England : 1993), 30 (2) , 206-214.e4More Information

Vemulapalli, Vidyasiri; Donovan, Katherine A; Seegar, Tom C M; Rogers, Julia M; Bae, Munhyung; Lumpkin, Ryan J; Cao, Ruili; Henke, Matthew T; Ray, Soumya S; Fischer, Eric S; Cuny, Gregory D; Blacklow, Stephen C  (2021). Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry, 60 (34) , 2593-2609More Information

Office
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-4351
tom.seegar@uc.edu