William Seibel

Associate Professor - Adjunct

Kowalewski Hall

Pharmacy Pharmaceutical Sciences - 0004

Research Support

Grant: #SRS 005313 Investigators:McOsker, Charles; Papoian, Ruben; Seibel, William; Wortman, Matthew 10-11-2007 -10-10-2010 Pharmasset, Inc. Pharmasset Drug Discovery Project Role:Collaborator $1,390,000.00 Closed Level:Industry

Grant: #S-845-010-002 / FA8650-08-C-6832 Investigators:Dean, Gary; Hassett, Daniel; Kotb, Malak; Lamkin, Thomas; Nelson, Sandra; Papoian, Ruben; Seibel, William; Strasser, Jane; Wortman, Matthew 08-26-2009 -02-11-2011 Defense Threat Reduction Agency INSIGHTS INteractome Science in Genomic High Throughput Studies Role:Collaborator $3,840,985.00 Active Level:Federal

Grant: #CHCM 105687 / 1 R01 CA141341-09A1 Investigators:Seibel, William 03-24-2009 -01-31-2013 National Cancer Institute Interaction of Rho GTPase with Regulators and Effectors Role:PI $55,040.00 Active Level:Federal

Grant: #106639 / 3 R01 CA125658-03S1 Investigators:Seibel, William 09-30-2009 -09-29-2011 National Cancer Institute Pharmacologic Targeting of Rac GTPase in Lymphomagenesis Role:PI $29,030.00 Closed Level:Federal

Publications

Peer Reviewed Publications

Chen, Yuanyuan; Chen, Yu; Jastrzebska, Beata; Golczak, Marcin; Gulati, Sahil; Tang, Hong; Seibel, William; Li, Xiaoyu; Jin, Hui; Han, Yong; Gao, Songqi; Zhang, Jianye; Liu, Xujie; Heidari-Torkabadi, Hossein; Stewart, Phoebe L; Harte, William E; Tochtrop, Gregory P; Palczewski, Krzysztof (2018. ) A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.Nature communications, , 9 (1 ) ,1976 More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2018. ) Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 9 (1 ) ,670 More Information

Dasgupta, Biplab; Seibel, William (2018. ) Compound C/Dorsomorphin: Its Use and Misuse as an AMPK Inhibitor.Methods in molecular biology (Clifton, N.J.), , 1732 ,195-202 More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2017. ) Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 8 (1 ) ,2099 More Information

Patil, Renukadevi; Kulshrestha, Arpita; Tikoo, Anjali; Fleetwood, Sara; Katara, Gajendra; Kolli, Bala; Seibel, William; Gilman-Sachs, Alice; Patil, Shivaputra A; Beaman, Kenneth D (2017. ) Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H?)-ATPase Inhibitors.Molecules (Basel, Switzerland), , 22 (9 ) , More Information

Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda (2018. ) Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells.Oncotarget, , 9 (22 ) ,15860-15875 More Information

James, Michael A; Seibel, William L; Kupert, Elena; Hu, Xiao X; Potharla, Vishwakanth Y; Anderson, Marshall W (2015. ) A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression.Anti-cancer drugs, , 26 (5 ) ,518-30 More Information

Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi (2015. ) Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.The Journal of biological chemistry, , 290 (20 ) ,12879-98 More Information

Chen, Yuanyuan; Tang, Hong; Seibel, William; Papoian, Ruben; Li, Xiaoyu; Lambert, Nevin A; Palczewski, Krzysztof (2015. ) A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Investigative ophthalmology & visual science, , 56 (4 ) ,2553-67 More Information

Dillehay, Kelsey L; Seibel, William L; Zhao, Daoli; Lu, Shan; Dong, Zhongyun (2015. ) Target validation and structure-activity analysis of a series of novel PCNA inhibitors.Pharmacology research & perspectives, , 3 (2 ) ,e00115 More Information

Patil, Shivaputra A; Pfeffer, Susan R; Seibel, William L; Pfeffer, Lawrence M; Miller, Duane D (2015. ) Identification of imidazoquinoline derivatives as potent antiglioma agents. Medicinal chemistry (Shariqah (United Arab Emirates)), , 11 (4 ) ,400-6

Zhang, Jianye; Dong, Zhiqian; Mundla, Sreenivasa Reddy; Hu, X Eric; Seibel, William; Papoian, Ruben; Palczewski, Krzysztof; Golczak, Marcin (2015. ) Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.Molecular pharmacology, , 87 (3 ) ,477-91 More Information

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi (2014. ) Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Chemistry & biology, , 21 (12 ) ,1618-28 More Information

Chen, Yuanyuan; Tang, Hong; Seibel, William; Papoian, Ruben; Oh, Ki; Li, Xiaoyu; Zhang, Jianye; Golczak, Marcin; Palczewski, Krzysztof; Kiser, Philip D (2014. ) Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase.Molecular pharmacology, , 86 (2 ) ,231-42 More Information

Kakarla, Ramesh; Liu, Jian; Naduthambi, Devan; Chang, Wonsuk; Mosley, Ralph T; Bao, Donghui; Steuer, Holly M Micolochick; Keilman, Meg; Bansal, Shalini; Lam, Angela M; Seibel, William; Neilson, Sandra; Furman, Phillip A; Sofia, Michael J (2014. ) Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.Journal of medicinal chemistry, , 57 (5 ) ,2136-60 More Information

Fells, James I; Lee, Sue Chin; Norman, Derek D; Tsukahara, Ryoko; Kirby, Jason R; Nelson, Sandra; Seibel, William; Papoian, Ruben; Patil, Renukadevi; Miller, Duane D; Parrill, Abby L; Pham, Truc-Chi; Baker, Daniel L; Bittman, Robert; Tigyi, Gabor (2014. ) Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.The FEBS journal, , 281 (4 ) ,1017-28 More Information

Simon, Nicholas; Bochman, Matthew L; Seguin, Sandlin; Brodsky, Jeffrey L; Seibel, William L; Schwacha, Anthony (2013. ) Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.Bioscience reports, , 33 (5 ) , More Information

Fells, James I; Lee, Sue Chin; Fujiwara, Yuko; Norman, Derek D; Lim, Keng Gat; Tsukahara, Ryoko; Liu, Jianxiong; Patil, Renukadevi; Miller, Duane D; Kirby, R Jason; Nelson, Sandra; Seibel, William; Papoian, Ruben; Parrill, Abby L; Baker, Daniel L; Bittman, Robert; Tigyi, Gabor (2013. ) Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.Molecular pharmacology, , 84 (3 ) ,415-24 More Information

Hao, Huifang; Maeda, Yutaka; Fukazawa, Takuya; Yamatsuji, Tomoki; Takaoka, Munenori; Bao, Xiao-Hong; Matsuoka, Junji; Okui, Tatsuo; Shimo, Tsuyoshi; Takigawa, Nagio; Tomono, Yasuko; Nakajima, Motowo; Fink-Baldauf, Iris M; Nelson, Sandra; Seibel, William; Papoian, Ruben; Whitsett, Jeffrey A; Naomoto, Yoshio (2013. ) Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer.PloS one, , 8 (8 ) ,e71093 More Information

Cash, Jennifer N; Angerman, Elizabeth B; Kirby, R Jason; Merck, Lisa; Seibel, William L; Wortman, Matthew D; Papoian, Ruben; Nelson, Sandra; Thompson, Thomas B (2013. ) Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A.Journal of biomolecular screening, , 18 (7 ) ,837-44 More Information

Panmanee, Warunya; Taylor, Deborah; Shea, Chloe J A; Tang, Hong; Nelson, Sandra; Seibel, William; Papoian, Ruben; Kramer, Ryan; Hassett, Daniel J; Lamkin, Thomas J (2013. ) High-throughput screening for small-molecule inhibitors of Staphylococcus epidermidis RP62a biofilms.Journal of biomolecular screening, , 18 (7 ) ,820-9 More Information

Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi (2013. ) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.Proceedings of the National Academy of Sciences of the United States of America, , 110 (8 ) ,3155-60 More Information

Patil, Shivaputra A; Wang, Jin; Li, Xiaochen S; Chen, Jianjun; Jones, Terreia S; Hosni-Ahmed, Amira; Patil, Renukadevi; Seibel, William L; Li, Wei; Miller, Duane D (2012. ) New substituted 4H-chromenes as anticancer agents.Bioorganic & medicinal chemistry letters, , 22 (13 ) ,4458-61 More Information

Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.Chemistry & biology, , 19 (6 ) ,699-710 More Information

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun (2012. ) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.Molecular pharmacology, , 81 (6 ) ,811-9 More Information

Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi (2012. ) Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.Chemistry & biology, , 19 (2 ) ,228-42 More Information

Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda (2011. ) Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.Molecular cancer therapeutics, , 10 (9 ) ,1740-50 More Information

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R (2010. ) Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin.Cancer biology & therapy, , 10 (12 ) ,1256-61 More Information

Rathore, Rakesh; Pribil, Patrick; Corr, Jay J; Seibel, William L; Evdokimov, Artem; Greis, Kenneth D (2010. ) Multiplex enzyme assays and inhibitor screening by mass spectrometry.Journal of biomolecular screening, , 15 (8 ) ,1001-7 More Information

Rathore, Rakesh; Corr, Jay J; Lebre, Daniel T; Seibel, William L; Greis, Kenneth D (2009. ) Extending matrix-assisted laser desorption/ionization triple quadrupole mass spectrometry enzyme screening assays to targets with small molecule substrates.Rapid communications in mass spectrometry : RCM, , 23 (20 ) ,3293-300 More Information

Wang, Zhao; Lu, Yan; Seibel, William; Miller, Duane D; Li, Wei (2009. ) Identifying novel molecular structures for advanced melanoma by ligand-based virtual screening.Journal of chemical information and modeling, , 49 (6 ) ,1420-7 More Information

Kontoyianni, Maria; Madhav, Prakash; Suchanek, Eric; Seibel, William (2008. ) Theoretical and practical considerations in virtual screening: a beaten field? .Current medicinal chemistry, , 15 (2 ) ,107-16

Evdokimov, Artem G; Pokross, Matthew; Walter, Richard L; Mekel, Marlene; Barnett, Bobby L; Amburgey, Jack; Seibel, William L; Soper, Shari J; Djung, Jane F; Fairweather, Neil; Diven, Conrad; Rastogi, Vinit; Grinius, Leo; Klanke, Charles; Siehnel, Richard; Twinem, Tracy; Andrews, Ryan; Curnow, Alan (2007. ) Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.Proteins, , 66 (3 ) ,538-46 More Information

Hu, X Eric; Kim, Nick K; Gray, Jeffrey L; Almstead, Ji-In K; Seibel, William L; Ledoussal, Benoit (2003. ) Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.Journal of medicinal chemistry, , 46 (17 ) ,3655-61 More Information