William Seibel

Grant: #SRS 005313 Investigators:McOsker, Charles; Papoian, Ruben; Seibel, William; Wortman, Matthew 10-11-2007 -10-10-2010 Pharmasset, Inc. Pharmasset Drug Discovery Project Role:Collaborator $1,390,000.00 Closed Level:Industry

Grant: #S-845-010-002 / FA8650-08-C-6832 Investigators:Dean, Gary; Hassett, Daniel; Kotb, Malak; Lamkin, Thomas; Nelson, Sandra; Papoian, Ruben; Seibel, William; Strasser, Jane; Wortman, Matthew 08-26-2009 -02-11-2011 Defense Threat Reduction Agency INSIGHTS INteractome Science in Genomic High Throughput Studies Role:Collaborator $3,840,985.00 Active Level:Federal

Grant: #CHCM 105687 / 1 R01 CA141341-09A1 Investigators:Seibel, William 03-24-2009 -01-31-2013 National Cancer Institute Interaction of Rho GTPase with Regulators and Effectors Role:PI $55,040.00 Active Level:Federal

Grant: #106639 / 3 R01 CA125658-03S1 Investigators:Seibel, William 09-30-2009 -09-29-2011 National Cancer Institute Pharmacologic Targeting of Rac GTPase in Lymphomagenesis Role:PI $29,030.00 Closed Level:Federal

Peer Reviewed Publications

Chen, Yuanyuan; Chen, Yu; Jastrzebska, Beata; Golczak, Marcin; Gulati, Sahil; Tang, Hong; Seibel, William; Li, Xiaoyu; Jin, Hui; Han, Yong; Gao, Songqi; Zhang, Jianye; Liu, Xujie; Heidari-Torkabadi, Hossein; Stewart, Phoebe L; Harte, William E; Tochtrop, Gregory P; Palczewski, Krzysztof  (2018). A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature communications, 9 (1) , 1976More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun  (2018). Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 (1) , 670More Information

Dasgupta, Biplab; Seibel, William  (2018). Compound C/Dorsomorphin: Its Use and Misuse as an AMPK Inhibitor. Methods in molecular biology (Clifton, N.J.), 1732, 195-202More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun  (2017). Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 (1) , 2099More Information

Patil, Renukadevi; Kulshrestha, Arpita; Tikoo, Anjali; Fleetwood, Sara; Katara, Gajendra; Kolli, Bala; Seibel, William; Gilman-Sachs, Alice; Patil, Shivaputra A; Beaman, Kenneth D  (2017). Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H?)-ATPase Inhibitors. Molecules (Basel, Switzerland), 22 (9) More Information

Allaway, Robert J; Wood, Matthew D; Downey, Sondra L; Bouley, Stephanie J; Traphagen, Nicole A; Wells, Jason D; Batra, Jaya; Melancon, Sir Norman; Ringelberg, Carol; Seibel, William; Ratner, Nancy; Sanchez, Yolanda  (2018). Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget, 9 (22) , 15860-15875More Information

James, Michael A; Seibel, William L; Kupert, Elena; Hu, Xiao X; Potharla, Vishwakanth Y; Anderson, Marshall W  (2015). A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression. Anti-cancer drugs, 26 (5) , 518-30More Information

Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi  (2015). Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry, 290 (20) , 12879-98More Information

Chen, Yuanyuan; Tang, Hong; Seibel, William; Papoian, Ruben; Li, Xiaoyu; Lambert, Nevin A; Palczewski, Krzysztof  (2015). A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Investigative ophthalmology & visual science, 56 (4) , 2553-67More Information

Dillehay, Kelsey L; Seibel, William L; Zhao, Daoli; Lu, Shan; Dong, Zhongyun  (2015). Target validation and structure-activity analysis of a series of novel PCNA inhibitors. Pharmacology research & perspectives, 3 (2) , e00115More Information

Patil, Shivaputra A; Pfeffer, Susan R; Seibel, William L; Pfeffer, Lawrence M; Miller, Duane D  (2015). Identification of imidazoquinoline derivatives as potent antiglioma agents. Medicinal chemistry (Shariqah (United Arab Emirates)), 11 (4) , 400-6

Zhang, Jianye; Dong, Zhiqian; Mundla, Sreenivasa Reddy; Hu, X Eric; Seibel, William; Papoian, Ruben; Palczewski, Krzysztof; Golczak, Marcin  (2015). Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Molecular pharmacology, 87 (3) , 477-91More Information

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi  (2014). Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 (12) , 1618-28More Information

Chen, Yuanyuan; Tang, Hong; Seibel, William; Papoian, Ruben; Oh, Ki; Li, Xiaoyu; Zhang, Jianye; Golczak, Marcin; Palczewski, Krzysztof; Kiser, Philip D  (2014). Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Molecular pharmacology, 86 (2) , 231-42More Information

Kakarla, Ramesh; Liu, Jian; Naduthambi, Devan; Chang, Wonsuk; Mosley, Ralph T; Bao, Donghui; Steuer, Holly M Micolochick; Keilman, Meg; Bansal, Shalini; Lam, Angela M; Seibel, William; Neilson, Sandra; Furman, Phillip A; Sofia, Michael J  (2014). Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives. Journal of medicinal chemistry, 57 (5) , 2136-60More Information

Fells, James I; Lee, Sue Chin; Norman, Derek D; Tsukahara, Ryoko; Kirby, Jason R; Nelson, Sandra; Seibel, William; Papoian, Ruben; Patil, Renukadevi; Miller, Duane D; Parrill, Abby L; Pham, Truc-Chi; Baker, Daniel L; Bittman, Robert; Tigyi, Gabor  (2014). Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The FEBS journal, 281 (4) , 1017-28More Information

Simon, Nicholas; Bochman, Matthew L; Seguin, Sandlin; Brodsky, Jeffrey L; Seibel, William L; Schwacha, Anthony  (2013). Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Bioscience reports, 33 (5) More Information

Fells, James I; Lee, Sue Chin; Fujiwara, Yuko; Norman, Derek D; Lim, Keng Gat; Tsukahara, Ryoko; Liu, Jianxiong; Patil, Renukadevi; Miller, Duane D; Kirby, R Jason; Nelson, Sandra; Seibel, William; Papoian, Ruben; Parrill, Abby L; Baker, Daniel L; Bittman, Robert; Tigyi, Gabor  (2013). Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular pharmacology, 84 (3) , 415-24More Information

Hao, Huifang; Maeda, Yutaka; Fukazawa, Takuya; Yamatsuji, Tomoki; Takaoka, Munenori; Bao, Xiao-Hong; Matsuoka, Junji; Okui, Tatsuo; Shimo, Tsuyoshi; Takigawa, Nagio; Tomono, Yasuko; Nakajima, Motowo; Fink-Baldauf, Iris M; Nelson, Sandra; Seibel, William; Papoian, Ruben; Whitsett, Jeffrey A; Naomoto, Yoshio  (2013). Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. PloS one, 8 (8) , e71093More Information

Cash, Jennifer N; Angerman, Elizabeth B; Kirby, R Jason; Merck, Lisa; Seibel, William L; Wortman, Matthew D; Papoian, Ruben; Nelson, Sandra; Thompson, Thomas B  (2013). Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A. Journal of biomolecular screening, 18 (7) , 837-44More Information

Panmanee, Warunya; Taylor, Deborah; Shea, Chloe J A; Tang, Hong; Nelson, Sandra; Seibel, William; Papoian, Ruben; Kramer, Ryan; Hassett, Daniel J; Lamkin, Thomas J  (2013). High-throughput screening for small-molecule inhibitors of Staphylococcus epidermidis RP62a biofilms. Journal of biomolecular screening, 18 (7) , 820-9More Information

Shang, Xun; Marchioni, Fillipo; Evelyn, Chris R; Sipes, Nisha; Zhou, Xuan; Seibel, William; Wortman, Matthew; Zheng, Yi  (2013). Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proceedings of the National Academy of Sciences of the United States of America, 110 (8) , 3155-60More Information

Patil, Shivaputra A; Wang, Jin; Li, Xiaochen S; Chen, Jianjun; Jones, Terreia S; Hosni-Ahmed, Amira; Patil, Renukadevi; Seibel, William L; Li, Wei; Miller, Duane D  (2012). New substituted 4H-chromenes as anticancer agents. Bioorganic & medicinal chemistry letters, 22 (13) , 4458-61More Information

Shang, Xun; Marchioni, Fillipo; Sipes, Nisha; Evelyn, Chris R; Jerabek-Willemsen, Moran; Duhr, Stefan; Seibel, William; Wortman, Matthew; Zheng, Yi  (2012). Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chemistry & biology, 19 (6) , 699-710More Information

Tan, Zongqing; Wortman, Matthew; Dillehay, Kelsey L; Seibel, William L; Evelyn, Chris R; Smith, Shanna J; Malkas, Linda H; Zheng, Yi; Lu, Shan; Dong, Zhongyun  (2012). Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Molecular pharmacology, 81 (6) , 811-9More Information

Bosco, Emily E; Kumar, Sachin; Marchioni, Filippo; Biesiada, Jacek; Kordos, Miroslaw; Szczur, Kathleen; Meller, Jarek; Seibel, William; Mizrahi, Ariel; Pick, Edgar; Filippi, Marie-Dominique; Zheng, Yi  (2012). Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chemistry & biology, 19 (2) , 228-42More Information

Wood, Matthew; Rawe, Melissa; Johansson, Gunnar; Pang, Shu; Soderquist, Ryan S; Patel, Ami V; Nelson, Sandra; Seibel, William; Ratner, Nancy; Sanchez, Yolanda  (2011). Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Molecular cancer therapeutics, 10 (9) , 1740-50More Information

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R  (2010). Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 (12) , 1256-61More Information

Rathore, Rakesh; Pribil, Patrick; Corr, Jay J; Seibel, William L; Evdokimov, Artem; Greis, Kenneth D  (2010). Multiplex enzyme assays and inhibitor screening by mass spectrometry. Journal of biomolecular screening, 15 (8) , 1001-7More Information

Rathore, Rakesh; Corr, Jay J; Lebre, Daniel T; Seibel, William L; Greis, Kenneth D  (2009). Extending matrix-assisted laser desorption/ionization triple quadrupole mass spectrometry enzyme screening assays to targets with small molecule substrates. Rapid communications in mass spectrometry : RCM, 23 (20) , 3293-300More Information

Wang, Zhao; Lu, Yan; Seibel, William; Miller, Duane D; Li, Wei  (2009). Identifying novel molecular structures for advanced melanoma by ligand-based virtual screening. Journal of chemical information and modeling, 49 (6) , 1420-7More Information

Kontoyianni, Maria; Madhav, Prakash; Suchanek, Eric; Seibel, William  (2008). Theoretical and practical considerations in virtual screening: a beaten field?. Current medicinal chemistry, 15 (2) , 107-16

Evdokimov, Artem G; Pokross, Matthew; Walter, Richard L; Mekel, Marlene; Barnett, Bobby L; Amburgey, Jack; Seibel, William L; Soper, Shari J; Djung, Jane F; Fairweather, Neil; Diven, Conrad; Rastogi, Vinit; Grinius, Leo; Klanke, Charles; Siehnel, Richard; Twinem, Tracy; Andrews, Ryan; Curnow, Alan  (2007). Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66 (3) , 538-46More Information

Hu, X Eric; Kim, Nick K; Gray, Jeffrey L; Almstead, Ji-In K; Seibel, William L; Ledoussal, Benoit  (2003). Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. Journal of medicinal chemistry, 46 (17) , 3655-61More Information