Soma Sengupta

Soma Sengupta , MD,PhD,FRCP

Harold C. Schott Endowed Brain Tumor Molecular Therapeutics Chair

Professional Summary

Current Role
Soma Sengupta is Harold C. Schott Endowed Chair of Brain Tumor Research and Co-Director of the University of Cincinnati Gardner Neuroscience Institute.
Key Highlights (optional)
Soma Sengupta is an adult Neuro-oncologist. She has an active laboratory that has multiple research focuses including adult (GBM, melanoma brain mets), pediatric brain tumors (medulloblastoma), and drug delivery technology.
Current Clinical Focus and Interests
Most of Soma Sengupta’s patients include patients with glioblastomas newly diagnosed or those with recurrent disease. Patients with genetic syndromes such as neurofibromatosis, tuberous sclerosis. In addition, Dr. Sengupta has a broad range of interests, and has collaborated with medical oncologists to co-manage secondary brain tumors.

Summary of Background/Previous Work History, Education and Achievements
Soma Sengupta has adult and some pediatric clinical training in neuro-oncology and extensive research training established a solid foundation for pursuit of translational research on primary and metastatic brain tumors. Dr. Sengupta has a long-standing research interest in structure-function of clinically important membrane transport proteins. She has conducted genetic and biochemical research on transporters (antifungal resistance; antigen processing; channels critical to neuronal function; channels important in cancer cells; ion pumps vital to metabolic processes). Dr. Sengupta did her Ph.D. training at the Univ. Cambridge, and post-doctoral training  (Yale, Johns Hopkins, Univ. Cambridge). For research funding, Dr. Sengupta has been continuously funded by the NIH (NINDS-R25, NCI-K12, NINDS-K08).   


Bachelor's Degree: University of Wales U.K., 1990 (Biochemistry)

Doctoral Degree: University of Cambridge U.K., 1994 (Biochemistry)

Medical Degree: University of Cambridge U.K., 2002


United Council for Neurologic Subspecialties (Certification Date: 08-31-2015 )

American Board of Psychiatry and Neurology (Neurology) (Certification Date: 09-22-2011 ) - (Recertification Date: to 01-15-2022 )

Clinical Interests


Brain Tumor


Positions and Work Experience

2013 -2016 Neuro-oncology Attending, BIDMC-Harvard, Boston

2016 -2019 Assistant Professor in Neuro-oncology, Emory University, Atlanta

Research Support

Grant: #MSSF2100035 Investigators:Rao, Rohan; Sengupta, Soma 06-01-2021 -08-31-2021 American Brain Tumor Association Validating RNA-nanoparticles for Focused Ultrasound Delivery to Glioblastomas Role:Collaborator 3000.00 Awarded Level:Non Profit

Investigators:Rao, Rohan; Sengupta, Soma 06-07-2021 -08-09-2021 American Academy of Neurology Validating RNA-nanoparticles for Focused Ultrasound Delivery to Glioblastomas Role:PI 3000.00 Hold Level:Non Profit

Grant: #R01CA255331 Investigators:Phoenix, Timothy; Sasaki, Atsuo; Sengupta, Soma; Takiar, Vinita 07-07-2021 -06-30-2026 National Cancer Institute Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2 Role:Collaborator 413481.00 Awarded Level:Federal

Grant: #21-054 Investigators:Sengupta, Soma 11-10-2021 -11-10-2024 Dana-Farber Cancer Institute Phase Ib Trial of ASP8374 and Cemiplimab in Recurrent Malignant Glioma Patients Role:PI 0.00 Hold Level:Non Profit

Grant: #R61NS128232 Investigators:Desai, Pankaj; Gudelsky, Gary; Phoenix, Timothy; Plas, David; Rodenberg, Cynthia; Sengupta, Soma; Wise-Draper, Trisha 08-01-2022 -07-31-2025 National Institute of Neurological Disorders and Stroke Translational Studies to facilitate Rational Therapeutic Combinations of Letrozole for the Treatment of Glioblastoma Role:Collaborator 389244.00 Awarded Level:Federal

Grant: #INCB 54828-209 -12-15-2023 Incyte Corporation A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tum Role:PI 0.00 Awarded Level:Industry

Grant: #INCB 54828-209 -12-15-2023 Incyte Corporation A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tum Role:PI 0.00 Awarded Level:Industry

Grant: #14379-201- IGV1031 01-12-2023 -01-31-2028 Medpace Inc. A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Safety and Efficacy of IGV-001, an Autologous Cell Immunotherapy With Antisense Oligonucleotide (IMV-001) Targ Role:PI 0.00 Active Level:Industry

Grant: #14379-201- IGV1031 01-12-2023 -01-31-2028 Medpace Inc. A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Safety and Efficacy of IGV-001, an Autologous Cell Immunotherapy With Antisense Oligonucleotide (IMV-001) Targ Role:PI 0.00 Active Level:Industry


Peer Reviewed Publications

Lowder, Lindsey; Hauenstein, Jennifer; Woods, Ashley; Chen, Hsiao-Rong; Rupji, Manali; Kowalski, Jeanne; Olson, Jeffrey J; Saxe, Debra; Schniederjan, Matthew; Neill, Stewart; Weinberg, Brent; Sengupta, Soma (2019. ) Gliosarcoma: distinct molecular pathways and genomic alterations identified by DNA copy number/SNP microarray analysis.Journal of neuro-oncology, , 143 (3 ) ,381-392 More Information

Kallay, Laura; Keskin, Havva; Ross, Alexandra; Rupji, Manali; Moody, Olivia A; Wang, Xin; Li, Guanguan; Ahmed, Taukir; Rashid, Farjana; Stephen, Michael Rajesh; Cottrill, Kirsten A; Nuckols, T Austin; Xu, Maxwell; Martinson, Deborah E; Tranghese, Frank; Pei, Yanxin; Cook, James M; Kowalski, Jeanne; Taylor, Michael D; Jenkins, Andrew; Pomeranz Krummel, Daniel A; Sengupta, Soma (2019. ) Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.Journal of neuro-oncology, , 142 (3 ) ,411-422 More Information

Karschnia, Philipp; Sengupta, Soma; Dietrich, Jorg (2019. ) MRI findings in trigeminal neuropathy: bilateral Meckel's cave lesions.Acta neurologica Belgica, , More Information

Doyle, Sean P; Gurbani, Saumya S; Ross, Alexandra S; Rosen, Havi; Barrett, Charlice Dunn; Olson, Jeffrey J; Shim, Hyunsuk; Shu, Hui-Kuo; Sengupta, Soma (2018. ) The role of erlotinib and the Optune device in a patient with an epidermal growth factor receptor viii amplified glioblastoma.Oxford medical case reports, , 2018 (12 ) ,omy095 More Information

Clark, Amanda R; Calligaris, David; Regan, Michael S; Pomeranz Krummel, Daniel; Agar, Jeffrey N; Kallay, Laura; MacDonald, Tobey; Schniederjan, Matthew; Santagata, Sandro; Pomeroy, Scott L; Agar, Nathalie Y R; Sengupta, Soma (2018. ) Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.Journal of neuro-oncology, , 140 (2 ) ,269-279 More Information

Melms, Johannes C; Ho, Ka-Wai; Thummalapalli, Rohit; Tyler, Janice; Brinker, Titus Josef; Singh, Veena; Sengupta, Soma; Mier, James; Izar, Benjamin (2018. ) Implementation of cell-free tumor DNA sequencing from the cerebrospinal fluid to guide treatment in a patient with primary leptomeningeal melanoma: A case report.Molecular and clinical oncology, , 9 (1 ) ,58-61 More Information

Archer, Tenley C; Sengupta, Soma; Pomeroy, Scott L (2018. ) Brain cancer genomics and epigenomics.Handbook of clinical neurology, , 148 ,785-797 More Information

Sengupta, Soma; Pomeranz Krummel, Daniel; Pomeroy, Scott (2017. ) The evolution of medulloblastoma therapy to personalized medicine.F1000Research, , 6 ,490 More Information

Sengupta, Soma; Voloschin, Alfredo (2016. ) Redefining Management of Adult Low-Grade Gliomas.Journal of oncology practice, , 12 (12 ) ,1244-1245 More Information

Jonas, Oliver; Calligaris, David; Methuku, Kashi Reddy; Poe, Michael M; Francois, Jessica Pierre; Tranghese, Frank; Changelian, Armen; Sieghart, Werner; Ernst, Margot; Krummel, Daniel A Pomeranz; Cook, James M; Pomeroy, Scott L; Cima, Michael; Agar, Nathalie Y R; Langer, Robert; Sengupta, Soma (2016. ) First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of biomedical nanotechnology, , 12 (6 ) ,1297-302

Mahadevan, Anand; Sampson, Carrie; LaRosa, Salvatore; Floyd, Scott R; Wong, Eric T; Uhlmann, Erik J; Sengupta, Soma; Kasper, Ekkehard M (2015. ) Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.Radiation oncology (London, England), , 10 ,245 More Information

Ippen, Franziska M; Mahadevan, Anand; Wong, Eric T; Uhlmann, Erik J; Sengupta, Soma; Kasper, Ekkehard M (2015. ) Stereotactic Radiosurgery for Renal Cancer Brain Metastasis: Prognostic Factors and the Role of Whole-Brain Radiation and Surgical Resection.Journal of oncology, , 2015 ,636918 More Information

Sengupta, Soma; Benkers, Tara; Blitstein, Marisa; Palmer, Edwin; Plotkin, Scott R; Abramson, Jeremy S (2014. ) Posterior reversible encephalopathy syndrome (PRES) complicating newly-diagnosed diffuse large B-cell lymphoma.Clinical lymphoma, myeloma & leukemia, , 14 (4 ) ,e111-3 More Information

Sengupta, Soma; Weeraratne, Shyamal D; Cho, Yoon-Jae; Pomeroy, Scott L (2014. ) Could ?5-GABA-A receptor activation be used as a target for managing medulloblastomas?.CNS oncology, , 3 (4 ) ,245-7 More Information

Sengupta, Soma; Weeraratne, Shyamal Dilhan; Sun, Hongyu; Phallen, Jillian; Rallapalli, Sundari K; Teider, Natalia; Kosaras, Bela; Amani, Vladimir; Pierre-Francois, Jessica; Tang, Yujie; Nguyen, Brian; Yu, Furong; Schubert, Simone; Balansay, Brianna; Mathios, Dimitris; Lechpammer, Mirna; Archer, Tenley C; Tran, Phuoc; Reimer, Richard J; Cook, James M; Lim, Michael; Jensen, Frances E; Pomeroy, Scott L; Cho, Yoon-Jae (2014. ) ?5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth.Acta neuropathologica, , 127 (4 ) ,593-603 More Information

Christman, Mitalee P; Turbett, Sarah E; Sengupta, Soma; Bakhadirov, Khamidulla U; Williamson, Craig A; Nayak, Lakshmi; Milligan, Tracey; Katz, Joel T (2014. ) Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature.Oxford medical case reports, , 2014 (1 ) ,1-4 More Information

Sengupta, Soma; Tarsy, Daniel; Joyce, Robin; Jeyapalan, Suriya (2013. ) Novel use of dual immunomodulation for treating stiff-person syndrome, cerebellar variant.Movement disorders : official journal of the Movement Disorder Society, , 28 (13 ) ,1905-6 More Information

Pugh, Trevor J; Weeraratne, Shyamal Dilhan; Archer, Tenley C; Pomeranz Krummel, Daniel A; Auclair, Daniel; Bochicchio, James; Carneiro, Mauricio O; Carter, Scott L; Cibulskis, Kristian; Erlich, Rachel L; Greulich, Heidi; Lawrence, Michael S; Lennon, Niall J; McKenna, Aaron; Meldrim, James; Ramos, Alex H; Ross, Michael G; Russ, Carsten; Shefler, Erica; Sivachenko, Andrey; Sogoloff, Brian; Stojanov, Petar; Tamayo, Pablo; Mesirov, Jill P; Amani, Vladimir; Teider, Natalia; Sengupta, Soma; Francois, Jessica Pierre; Northcott, Paul A; Taylor, Michael D; Yu, Furong; Crabtree, Gerald R; Kautzman, Amanda G; Gabriel, Stacey B; Getz, Gad; Jäger, Natalie; Jones, David T W; Lichter, Peter; Pfister, Stefan M; Roberts, Thomas M; Meyerson, Matthew; Pomeroy, Scott L; Cho, Yoon-Jae (2012. ) Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Nature, , 488 (7409 ) ,106-10 More Information

Weeraratne, Shyamal Dilhan; Amani, Vladimir; Teider, Natalia; Pierre-Francois, Jessica; Winter, Dominic; Kye, Min Jeong; Sengupta, Soma; Archer, Tenley; Remke, Marc; Bai, Alfa H C; Warren, Peter; Pfister, Stefan M; Steen, Judith A J; Pomeroy, Scott L; Cho, Yoon-Jae (2012. ) Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma.Acta neuropathologica, , 123 (4 ) ,539-52 More Information

Maski, Kiran P; Sengupta, Soma; Silvera, Michelle; Rivkin, Michael J (2011. ) Intracranial artery dissection in an adolescent with Marfan syndrome.Pediatric neurology, , 45 (1 ) ,39-41 More Information

Sengupta, Soma; Pedersen, Nigel P; Davis, James E; Rojas, Rafael; Reddy, Hasini; Kasper, Ekkehard; Greenstein, Patricia; Wong, Eric T (2011. ) Illusion of stroke: intravascular lymphomatosis. Reviews in neurological diseases, , 8 (3-4 ) ,e107-13

Nathan, James A; Sengupta, Soma; Wood, Stephen A; Admon, Arie; Markson, Gabriel; Sanderson, Chris; Lehner, Paul J (2008. ) The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.Traffic (Copenhagen, Denmark), , 9 (7 ) ,1130-45 More Information

Karttunen, J T; Lehner, P J; Gupta, S S; Hewitt, E W; Cresswell, P (2001. ) Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).Proceedings of the National Academy of Sciences of the United States of America, , 98 (13 ) ,7431-6 More Information

Hewitt, E W; Gupta, S S; Lehner, P J (2001. ) The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.The EMBO journal, , 20 (3 ) ,387-96 More Information

dos Santos, C F; DeWitt, N D; Gupta, S S; Allen, K E; Slayman, C W (2000. ) Epitope-tagged constructs of the yeast plasma-membrane H(+)-ATPase.IUBMB life, , 49 (2 ) ,153-9 More Information

Gupta, S S; DeWitt, N D; Allen, K E; Slayman, C W (1998. ) Evidence for a salt bridge between transmembrane segments 5 and 6 of the yeast plasma-membrane H+-ATPase.The Journal of biological chemistry, , 273 (51 ) ,34328-34 More Information

Sen Gupta, S; Kerridge, D; Chevallier, M R (1995. ) A purine permease in Candida glabrata.FEMS microbiology letters, , 126 (1 ) ,93-6 More Information

Vanden Bossche, H; Warnock, D W; Dupont, B; Kerridge, D; Sen Gupta, S; Improvisi, L; Marichal, P; Odds, F C; Provost, F; Ronin, O (1994. ) Mechanisms and clinical impact of antifungal drug resistance. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, , 32 Suppl 1 ,189-202

Gupta, S S; Canessa, C M (2000. ) Heterologous expression of a mammalian epithelial sodium channel in yeast.FEBS letters, , 481 (1 ) ,77-80 More Information

Press, Robert H; Shafer, Sarah L; Jiang, Renjian; Buchwald, Zachary S; Abugideiri, Mustafa; Tian, Sibo; Morgan, Tiffany M; Behera, Madhusmita; Sengupta, Soma; Voloschin, Alfredo D; Olson, Jeffrey J; Hasan, Shaakir; Blumenthal, Deborah T; Curran, Walter J; Eaton, Bree R; Shu, Hui-Kuo G; Zhong, Jim (2020. ) Optimal timing of chemoradiotherapy after surgical resection of glioblastoma: Stratification by validated prognostic classification.Cancer, , More Information

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Izar, Benjamin; Press, Robert H; Xu, Maxwell; Lowder, Lindsey; Kallay, Laura; Rupji, Manali; Rosen, Havi; Su, Jing; Curran, Walter; Olson, Jeffrey; Weinberg, Brent; Schniederjan, Matthew; Neill, Stewart; Lawson, David; Kowalski, Jeanne; Khan, Mohammad K; Sengupta, Soma (2020. ) Impact of Sequencing Radiation Therapy and Immune Checkpoint Inhibitors in the Treatment of Melanoma Brain Metastases.International journal of radiation oncology, biology, physics, , More Information

Sadigh, Gelareh; Gallagher, Kathleen; Obenchain, Jennifer; Benson, Al; Mitchell, Edith; Sengupta, Soma; Carlos, Ruth C (2019. ) Pilot Feasibility Study of an Oncology Financial Navigation Program in Brain Cancer Patients.Journal of the American College of Radiology : JACR, , 16 (10 ) ,1420-1424 More Information

Cicka, Danielle; Ford, Charles Lester; Templin, Erica; Pitts, Zachary; Gurbani, Saumya; Eaton, Bree; Lowder, Lindsey; Olson, Jeffrey; Weinberg, Brent D; Shim, Hyunsuk; Sengupta, Soma (2019. ) Presentation of treatment effect in glioblastoma after dose-escalation radiation therapy.Oxford medical case reports, , 2019 (9 ) ,omz085 More Information

Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma (2021. ) Reuse of Molecules for Glioblastoma Therapy.Pharmaceuticals (Basel, Switzerland), , 14 (2 ) , More Information

Worrell, Stacey L; Kirschner, Michelle L; Shatz, Rhonna S; Sengupta, Soma; Erickson, Melissa G (2021. ) Interdisciplinary Approaches to Survivorship with a Focus on the Low-grade and Benign Brain Tumor Populations.Current oncology reports, , 23 (2 ) ,19 More Information

Bachir, Suha; Shah, Sanjit; Shapiro, Scott; Koehler, Abigail; Mahammedi, Abdelkader; Samy, Ravi N; Zuccarello, Mario; Schorry, Elizabeth; Sengupta, Soma (2021. ) Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis.International journal of molecular sciences, , 22 (2 ) , More Information

Gallia, Gary L; Holdhoff, Matthias; Brem, Henry; Joshi, Avadhut D; Hann, Christine L; Bai, Ren-Yuan; Staedtke, Verena; Blakeley, Jaishri O; Sengupta, Soma; Jarrell, T Che; Wollett, Jessica; Szajna, Kelly; Helie, Nicole; Mattox, Austin K; Ye, Xiaobu; Rudek, Michelle A; Riggins, Gregory J Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial.Neuro-oncology advances, , 3 (1 ) ,vdaa154 More Information

Mahammedi, Abdelkader; Saba, Luca; Vagal, Achala; Leali, Michela; Rossi, Andrea; Gaskill, Mary; Sengupta, Soma; Zhang, Bin; Carriero, Alessandro; Bachir, Suha; Crivelli, Paola; Paschè, Alessio; Premi, Enrico; Padovani, Alessandro; Gasparotti, Roberto (2020. ) Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study.Radiology, , 297 (2 ) ,E270-E273 More Information

Pomeranz Krummel, Daniel A; Nasti, Tahseen H; Kaluzova, Milota; Kallay, Laura; Bhattacharya, Debanjan; Melms, Johannes C; Izar, Benjamin; Xu, Maxwell; Burnham, Andre; Ahmed, Taukir; Li, Guanguan; Lawson, David; Kowalski, Jeanne; Cao, Yichun; Switchenko, Jeffrey M; Ionascu, Dan; Cook, James M; Medvedovic, Mario; Jenkins, Andrew; Khan, Mohammad K; Sengupta, Soma (2021. ) Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity.International journal of radiation oncology, biology, physics, , 109 (4 ) ,1040-1053 More Information

Bhattacharya, Debanjan; Pomeroy, Scott L; Pomeranz Krummel, Daniel A; Sengupta, Soma (2020. ) Epigenetics and survivorship in pediatric brain tumor patients.Journal of neuro-oncology, , 150 (1 ) ,77-83 More Information

Chakraborty, Samrat; Dlie, Zewdu Yilma; Mukherjee, Biswajit; Besra, Shila Elizabeth; Sengupta, Soma; Sen, Ramkrishna; Mukherjee, Alankar (2020. ) A Comparative Investigation of the Ability of Various Aptamer-Functionalized Drug Nanocarriers to Induce Selective Apoptosis in Neoplastic Hepatocytes: In Vitro and In Vivo Outcome.AAPS PharmSciTech, , 21 (3 ) ,89 More Information

Published Books

Sengupta S (2018. ) Mascot Press (Author)

Additional Publications

Book of Poems

Sengupta S (1994. ) UK, Minerva Press (Author)

Sengupta S (2003. ) Ashes, born on the wind .Ashes, born on the wind .Cambridge, UK, FireWater Press (Author)