Mathieu Guy Basile Sertorio, PhD

BS: Toulon University LaGarde, France, 2006 (Biomedical Engineering)

Masters of Science: Aixe-Marseille University Marseille, France, 2007 (Human Pathology)

PhD: Marseille University Marseille, France, 2012 (Immunology)

Grant: #CancerFree Kids 03-06-2021 -12-31-2021 CancerFree Kids Improving the Outcome of Aggressive Childhood Lymphomas by Combining Proton Precision Therapy with Mitochondrial Targeting Role:PI 29665.42 Awarded Level:Non Profit

Grant: #CancerFree Kids 03-06-2021 -12-31-2021 CancerFree Kids Improving the Outcome of Aggressive Childhood Lymphomas by Combining Proton Precision Therapy with Mitochondrial Targeting Role:PI 29665.42 Awarded Level:Non Profit

Investigators:Sertorio, Mathieu 03-15-2021 -05-31-2022 Cincinnati Children's Hospital Medical Center Proton FLASH effect on mouse skin toxicity and fibrosis Role:PI 120325.00 Hold Level:Non Profit

Investigators:Sertorio, Mathieu 05-01-2022 -04-30-2023 Cincinnati Children's Hospital Medical Center Study of FLASH Proton Therapy Effect on The Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Role:PI 143530.30 Hold Level:Non Profit

Grant: #24TPA1303687 Investigators:Kotagiri, Nalinikanth; Sadayappan, Sakthivel; Sertorio, Mathieu 07-01-2024 -06-30-2027 American Heart Association - National Chapter Engineered probiotic to mitigate heart disease associated inflammation Role:Collaborator 100000.00 Hold Level:Non Profit

Grant: #R01CA279962 JIT Investigators:Desai, Pankaj; Faber, Ed; Kotagiri, Nalinikanth; Sertorio, Mathieu; Xie, Changchun 12-01-2023 -11-30-2028 National Cancer Institute Genetically-encoded molecular imaging of genome-edited immune cells Role:Collaborator 0.00 Hold Level:Federal

Peer Reviewed Publications

Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I  (2021). Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 (3) , 424-435.e6More Information

Cunningham, Shannon; McCauley, Shelby; Vairamani, Kanimozhi; Speth, Joseph; Girdhani, Swati; Abel, Eric; Sharma, Ricky A; Perentesis, John P; Wells, Susanne I; Mascia, Anthony; Sertorio, Mathieu  (2021). FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cancers, 13 (5) More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I  (2021). Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 155, 293-303More Information

Williams, Michael T; Sugimoto, Chiho; Regan, Samantha L; Pitzer, Emily M; Fritz, Adam L; Mascia, Anthony E; Sertorio, Mathieu; Vatner, Ralph E; Perentesis, John P; Vorhees, Charles V  (2020). Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Scientific reports, 10 (1) , 21584More Information

Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette  (2020). DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12 (7) More Information

Nowrouzi, Ali; Sertorio, Mathieu G; Akbarpour, Mahdi; Knoll, Maximillian; Krunic, Damir; Kuhar, Matthew; Schwager, Christian; Brons, Stephan; Debus, Jürgen; Wells, Susanne I; Wells, James M; Abdollahi, Amir  (2020). Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers, 12 (2) More Information

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I  (2018). Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 (1) , 40-48More Information

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M  (2018). Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59, 40-50.e3More Information

Sertorio, Mathieu; Du, Wei; Amarachintha, Surya; Wilson, Andrew; Pang, Qishen  (2017). In Vivo RNAi Screen Unveils PPAR? as a Regulator of Hematopoietic Stem Cell Homeostasis. Stem cell reports, 8 (5) , 1242-1255More Information

Sertorio, Mathieu; Amarachintha, Surya; Wilson, Andrew; Pang, Qishen  (2016). Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway. Journal of immunology (Baltimore, Md. : 1950), 196 (7) , 2986-94More Information

Amarachintha, Surya; Sertorio, Mathieu; Wilson, Andrew; Li, Xiaoli; Pang, Qishen  (2015). Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling. Stem cells (Dayton, Ohio), 33 (11) , 3382-96More Information

Li, Xiaoli; Zhang, Tingting; Wilson, Andrew; Amarachintha, Surya; Sertorio, Mathieu; Pang, Qishen  (2015). Transcriptional profiling of Foxo3a and Fancd2 regulated genes in mouse hematopoietic stem cells. Genomics data, 4, 148-149More Information

Mascia, Anthony; McCauley, Shelby; Speth, Joseph; Nunez, Stefanno Alarcon; Boivin, Gael; Vilalta, Marta; Sharma, Ricky A; Perentesis, John P; Sertorio, Mathieu  (2023). Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice. International journal of radiation oncology, biology, physicsMore Information

Siddiqui, Nabil A; Ventrola, Alec J; Hartman, Alexandra R; Konare, Tohonne; Kamble, Nitin S; Thomas, Shindu C; Madaan, Tushar; Kharofa, Jordan; Sertorio, Mathieu G; Kotagiri, Nalinikanth  (2023). An Engineered Probiotic Platform for Cancer Epitope-Independent Targeted Radionuclide Therapy of Solid Tumors. Advanced healthcare materials, 12 (19) , e2202870More Information

Korns, Julianna; McCauley, Shelby; Lehn, Maria; Takiar, Vinita; Sertorio, Mathieu; Lamba, Michael  (2023). Varied Photon Radiation Sources Produce Differences in Cellular Response. Radiation research, 199 (4) , 422-428More Information

Daugherty, Emily C; Mascia, Anthony; Zhang, Yong; Lee, Eunsin; Xiao, Zhiyan; Sertorio, Mathieu; Woo, Jennifer; McCann, Claire; Russell, Kenneth; Levine, Lisa; Sharma, Ricky; Khuntia, Deepak; Bradley, Jeffrey; Simone, Charles B; Perentesis, John; Breneman, John  (2023). FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. JMIR research protocols, 12, e41812More Information

Mascia, Anthony E; Daugherty, Emily C; Zhang, Yongbin; Lee, Eunsin; Xiao, Zhiyan; Sertorio, Mathieu; Woo, Jennifer; Backus, Lori R; McDonald, Julie M; McCann, Claire; Russell, Kenneth; Levine, Lisa; Sharma, Ricky A; Khuntia, Dee; Bradley, Jeffrey D; Simone, Charles B; Perentesis, John P; Breneman, John C  (2023). Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. JAMA oncology, 9 (1) , 62-69More Information

Williams, Michael T; Sugimoto, Chiho; Regan, Samantha L; Pitzer, Emily M; Fritz, Adam L; Sertorio, Mathieu; Mascia, Anthony E; Vatner, Ralph E; Perentesis, John P; Vorhees, Charles V  (2022). Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PloS one, 17 (9) , e0274007More Information

Chihanga, Tafadzwa; Vicente-Muñoz, Sara; Ruiz-Torres, Sonya; Pal, Bidisha; Sertorio, Mathieu; Andreassen, Paul R; Khoury, Ruby; Mehta, Parinda; Davies, Stella M; Lane, Andrew N; Romick-Rosendale, Lindsey E; Wells, Susanne I  (2022). Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers, 14 (8) More Information

Dubey, Poornima; Sertorio, Mathieu; Takiar, Vinita  (2022). Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy. Cancers, 14 (3) More Information

Pathak, Bedika; Lange, Taylor E; Lampe, Kristin; Hollander, Ella; Oria, Marina; Murphy, Kendall P; Salomonis, Nathan; Sertorio, Mathieu; Oria, Marc  (2023). Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety. Cancers, 15 (20) More Information

Pathak, Bedika; Lange, Taylor E; Lampe, Kristin; Hollander, Ella; Oria, Marina; Murphy, Kendall P; Salomonis, Nathan; Sertorio, Mathieu; Oria, Marc  (2023). Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety. Cancers, 15 (20) More Information

Daugherty, E C; Zhang, Y; Xiao, Z; Mascia, A E; Sertorio, M; Woo, J; McCann, C; Russell, K J; Sharma, R A; Khuntia, D; Bradley, J D; Simone, C B; Breneman, J C; Perentesis, J P  (2024). FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach. Radiation oncology (London, England), 19 (1) , 34More Information

Chimote, Ameet A; Lehn, Maria A; Bhati, Jay; Mascia, Anthony E; Sertorio, Mathieu; Lamba, Michael A; Ionascu, Dan; Tang, Alice L; Langevin, Scott M; Khodoun, Marat V; Wise-Draper, Trisha M; Conforti, Laura  (2024). Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma. Cancers, 16 (5) More Information

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