Mathieu Guy Basile Sertorio , PhD

BS: Toulon University LaGarde, France, 2006 (Biomedical Engineering)

Masters of Science: Aixe-Marseille University Marseille, France, 2007 (Human Pathology)

PhD: Marseille University Marseille, France, 2012 (Immunology)

Grant: #CancerFree Kids 03-06-2021 -12-31-2021 CancerFree Kids Improving the Outcome of Aggressive Childhood Lymphomas by Combining Proton Precision Therapy with Mitochondrial Targeting Role:PI 29665.42 Awarded Level:Non Profit

Grant: #CancerFree Kids 03-06-2021 -12-31-2021 CancerFree Kids Improving the Outcome of Aggressive Childhood Lymphomas by Combining Proton Precision Therapy with Mitochondrial Targeting Role:PI 29665.42 Awarded Level:Non Profit

Investigators:Sertorio, Mathieu 03-15-2021 -05-31-2022 Cincinnati Children's Hospital Medical Center Proton FLASH effect on mouse skin toxicity and fibrosis Role:PI 120325.00 Hold Level:Non Profit

Investigators:Sertorio, Mathieu 05-01-2022 -04-30-2023 Cincinnati Children's Hospital Medical Center Study of FLASH Proton Therapy Effect on The Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Role:PI 143530.30 Hold Level:Non Profit

Peer Reviewed Publications

Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I (2021. ) Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.Cell stem cell, , 28 (3 ) ,424-435.e6 More Information

Cunningham, Shannon; McCauley, Shelby; Vairamani, Kanimozhi; Speth, Joseph; Girdhani, Swati; Abel, Eric; Sharma, Ricky A; Perentesis, John P; Wells, Susanne I; Mascia, Anthony; Sertorio, Mathieu (2021. ) FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice.Cancers, , 13 (5 ) , More Information

Sertorio, Mathieu; Nowrouzi, Ali; Akbarpour, Mahdi; Chetal, Kashish; Salomonis, Nathan; Brons, Stephan; Mascia, Anthony; Ionascu, Dan; McCauley, Shelby; Kupneski, Taylor; Köthe, Andreas; Debus, Jürgen; Perentesis, John P; Abdollahi, Amir; Zheng, Yi; Wells, Susanne I (2021. ) Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, , 155 ,293-303 More Information

Williams, Michael T; Sugimoto, Chiho; Regan, Samantha L; Pitzer, Emily M; Fritz, Adam L; Mascia, Anthony E; Sertorio, Mathieu; Vatner, Ralph E; Perentesis, John P; Vorhees, Charles V (2020. ) Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects.Scientific reports, , 10 (1 ) ,21584 More Information

Pease, Nicholas A; Shephard, Miranda S; Sertorio, Mathieu; Waltz, Susan E; Vinnedge, Lisa M Privette (2020. ) DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.Cancers, , 12 (7 ) , More Information

Nowrouzi, Ali; Sertorio, Mathieu G; Akbarpour, Mahdi; Knoll, Maximillian; Krunic, Damir; Kuhar, Matthew; Schwager, Christian; Brons, Stephan; Debus, Jürgen; Wells, Susanne I; Wells, James M; Abdollahi, Amir (2020. ) Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids.Cancers, , 12 (2 ) , More Information

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I (2018. ) Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy.International journal of particle therapy, , 5 (1 ) ,40-48 More Information

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M (2018. ) Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.Experimental hematology, , 59 ,40-50.e3 More Information

Sertorio, Mathieu; Du, Wei; Amarachintha, Surya; Wilson, Andrew; Pang, Qishen (2017. ) In Vivo RNAi Screen Unveils PPAR? as a Regulator of Hematopoietic Stem Cell Homeostasis.Stem cell reports, , 8 (5 ) ,1242-1255 More Information

Sertorio, Mathieu; Amarachintha, Surya; Wilson, Andrew; Pang, Qishen (2016. ) Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.Journal of immunology (Baltimore, Md. : 1950), , 196 (7 ) ,2986-94 More Information

Amarachintha, Surya; Sertorio, Mathieu; Wilson, Andrew; Li, Xiaoli; Pang, Qishen (2015. ) Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling.Stem cells (Dayton, Ohio), , 33 (11 ) ,3382-96 More Information

Li, Xiaoli; Zhang, Tingting; Wilson, Andrew; Amarachintha, Surya; Sertorio, Mathieu; Pang, Qishen (2015. ) Transcriptional profiling of Foxo3a and Fancd2 regulated genes in mouse hematopoietic stem cells.Genomics data, , 4 ,148-149 More Information

Mascia, Anthony; McCauley, Shelby; Speth, Joseph; Nunez, Stefanno Alarcon; Boivin, Gael; Vilalta, Marta; Sharma, Ricky A; Perentesis, John P; Sertorio, Mathieu (2023. ) Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice.International journal of radiation oncology, biology, physics, , More Information

Siddiqui, Nabil A; Ventrola, Alec J; Hartman, Alexandra R; Konare, Tohonne; Kamble, Nitin S; Thomas, Shindu C; Madaan, Tushar; Kharofa, Jordan; Sertorio, Mathieu G; Kotagiri, Nalinikanth (2023. ) An Engineered Probiotic Platform for Cancer Epitope-Independent Targeted Radionuclide Therapy of Solid Tumors.Advanced healthcare materials, , 12 (19 ) ,e2202870 More Information

Korns, Julianna; McCauley, Shelby; Lehn, Maria; Takiar, Vinita; Sertorio, Mathieu; Lamba, Michael (2023. ) Varied Photon Radiation Sources Produce Differences in Cellular Response.Radiation research, , 199 (4 ) ,422-428 More Information

Daugherty, Emily C; Mascia, Anthony; Zhang, Yong; Lee, Eunsin; Xiao, Zhiyan; Sertorio, Mathieu; Woo, Jennifer; McCann, Claire; Russell, Kenneth; Levine, Lisa; Sharma, Ricky; Khuntia, Deepak; Bradley, Jeffrey; Simone, Charles B; Perentesis, John; Breneman, John (2023. ) FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study.JMIR research protocols, , 12 ,e41812 More Information

Mascia, Anthony E; Daugherty, Emily C; Zhang, Yongbin; Lee, Eunsin; Xiao, Zhiyan; Sertorio, Mathieu; Woo, Jennifer; Backus, Lori R; McDonald, Julie M; McCann, Claire; Russell, Kenneth; Levine, Lisa; Sharma, Ricky A; Khuntia, Dee; Bradley, Jeffrey D; Simone, Charles B; Perentesis, John P; Breneman, John C (2023. ) Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial.JAMA oncology, , 9 (1 ) ,62-69 More Information

Williams, Michael T; Sugimoto, Chiho; Regan, Samantha L; Pitzer, Emily M; Fritz, Adam L; Sertorio, Mathieu; Mascia, Anthony E; Vatner, Ralph E; Perentesis, John P; Vorhees, Charles V (2022. ) Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model.PloS one, , 17 (9 ) ,e0274007 More Information

Chihanga, Tafadzwa; Vicente-Muñoz, Sara; Ruiz-Torres, Sonya; Pal, Bidisha; Sertorio, Mathieu; Andreassen, Paul R; Khoury, Ruby; Mehta, Parinda; Davies, Stella M; Lane, Andrew N; Romick-Rosendale, Lindsey E; Wells, Susanne I (2022. ) Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia.Cancers, , 14 (8 ) , More Information

Dubey, Poornima; Sertorio, Mathieu; Takiar, Vinita (2022. ) Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy.Cancers, , 14 (3 ) , More Information

Pathak, Bedika; Lange, Taylor E; Lampe, Kristin; Hollander, Ella; Oria, Marina; Murphy, Kendall P; Salomonis, Nathan; Sertorio, Mathieu; Oria, Marc (2023. ) Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety.Cancers, , 15 (20 ) , More Information

Pathak, Bedika; Lange, Taylor E; Lampe, Kristin; Hollander, Ella; Oria, Marina; Murphy, Kendall P; Salomonis, Nathan; Sertorio, Mathieu; Oria, Marc (2023. ) Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety.Cancers, , 15 (20 ) , More Information

Phone: 5137882656