Wenhai Shao , PhD

Associate Professor

Bachelor of Science: Jiangsu Normal University Jiangsu, China, 1994 (Biology)

Master of Science: Chinese Academy of Sciences, Wuhan Institute of Virology Wuhan, China, 2000

PhD: University of Lousiville Louisville, KY, 2005 (Immunology)

Fellow: University of Pennsylvania Philadelphia, PA, 2008

2012 -2016 Research Assistant Professor, Department of Microbiology and Immunology, Temple University, Philadelphia, PA

2008 -2012 Research Scientist, Temple University, Phladelphia, PA

2016 -2020 Assistant Professor, University of Cincinnati, Cincinnati, OH

Grant: #K01DK095067 Investigators:Shao, Wenhai 12-01-2016 -06-30-2018 National Inst of Diabetes and Digestive and Kidney Disease A critical role of TAM receptors in autoimmune nephritis Role:PI $646,595.00 Completed Type:Grant Level:National

Grant: #Kymera Therapeutics, LLC Investigators:Shao, Wenhai 05-21-2018 -08-21-2018 Kymera Therapeutics Inc. Kymera Project Role:PI $13,977.00 Completed Type:Contract

Grant: #R01DK116789 Investigators: Shao, Wenhai 04-01-2019 -03-31-2022 National Inst of Diabetes and Digestive and Kidney Disease Axl receptor tyrosine kinase, a potential therapeutic target in glomerulonephritis Role:PI $709,000.00 Active Type:Grant

Grant: #Innovator Award Investigators: Shao, Wenhai 06-01-2018 -06-01-2019 UC, College of Medicine Role:PI $30,000.00 Completed Type:Grant Level:Honorary

Grant: #Junior Faculty Pilot Award Investigators: Shao, Wenhai 01-01-2019 -01-01-2020 UC, College of Medicine, Department of Medicine Role:PI $30,000.00 Active Type:Grant

Grant: #IUIS Travel Grant Investigators:Shao, Wenhai 07-01-2019 -06-30-2020 American Association of Immunologists, Inc. AAI Travel grant Role:PI $2,500.00 Awarded Level:Private Non-Profit

Grant: #CCHMC / R21AI145304 Investigators:Shao, Wenhai 07-01-2020 -06-30-2022 National Institute of Allergy and Infectious Diseases Genetics of organ-specific lupus disease sequelae Role:PI $9,811.24 Active Level:Federal

Peer Reviewed Publications

Shao, Wen-Hai; Zhen, Yuxuan; Finkelman, Fred D; Cohen, Philip L (2014. ) The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking.Journal of autoimmunity, , 53 ,78-84 More Information

Zhen, Yuxuan; Priest, Stephen O; Shao, Wen-Hai (2016. ) Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis.Journal of immunology (Baltimore, Md. : 1950), , More Information

Shao, Wen-Hai; Shu, Daniel H; Zhen, Yuxuan; Hilliard, Brendan; Priest, Stephen O; Cesaroni, Matteo; Ting, Jenny P-Y; Cohen, Philip L (2016. ) Prion-like MAVS aggregation in lupus patients associates with increased interferon-I.Arthritis & rheumatology (Hoboken, N.J.), , More Information

Shao, Wen-Hai; Gamero, Ana M; Zhen, Yuxuan; Lobue, Monica J; Priest, Stephen O; Albandar, Hazem J; Cohen, Philip L (2015. ) Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3.Journal of immunology (Baltimore, Md. : 1950), , 195 (9 ) ,4136-43 More Information

Shao, Wen-Hai; Cohen, Philip L (2014. ) The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Expert review of clinical immunology, , 10 (5 ) ,573-82 More Information

Shao, Wen-Hai; Zhen, Yuxuan; Finkelman, Fred D; Eisenberg, Robert A; Cohen, Philip L (2012. ) Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression.Journal of autoimmunity, , 39 (4 ) ,412-9 More Information

Zheng, Peng; Gao, Hong C; Li, Qi; Shao, Wei H; Zhang, Mei L; Cheng, Ke; Yang, De Y; Fan, Song H; Chen, Liang; Fang, Liang; Xie, Peng (2012. ) Plasma metabonomics as a novel diagnostic approach for major depressive disorder.Journal of proteome research, , 11 (3 ) ,1741-8 More Information

Hong, Cynthia; Kidani, Yoko; A-Gonzalez, Noelia; Phung, Tram; Ito, Ayaka; Rong, Xin; Ericson, Katrin; Mikkola, Hanna; Beaven, Simon W; Miller, Lloyd S; Shao, Wen-Hai; Cohen, Philip L; Castrillo, Antonio; Tontonoz, Peter; Bensinger, Steven J (2012. ) Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.The Journal of clinical investigation, , 122 (1 ) ,337-47 More Information

Otvos, Laszlo; Shao, Wen-Hai; Vanniasinghe, Anne S; Amon, Michael A; Holub, Marianna Csilla; Kovalszky, Ilona; Wade, John D; Doll, Michelle; Cohen, Philip L; Manolios, Nicholas; Surmacz, Eva (2011. ) Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis.Peptides, , 32 (8 ) ,1567-74 More Information

Shao, Wen-Hai; Cohen, Philip L (2011. ) Disturbances of apoptotic cell clearance in systemic lupus erythematosus.Arthritis research & therapy, , 13 (1 ) ,202 More Information

Shao, Wen-Hai; Kuan, Anita P; Wang, Charlie; Abraham, Valsamma; Waldman, Meryl A; Vogelgesang, Antje; Wittenburg, Gretel; Choudhury, Arpita; Tsao, Patricia Y; Miwa, Takashi; Eisenberg, Robert A; Cohen, Philip L (2010. ) Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses.Journal of autoimmunity, , 35 (4 ) ,368-74 More Information

Rahman, Ziaur S M; Shao, Wen-Hai; Khan, Tahsin N; Zhen, Yuxuan; Cohen, Philip L (2010. ) Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses.Journal of immunology (Baltimore, Md. : 1950), , 185 (10 ) ,5859-68 More Information

Shao, Wen-Hai; Zhen, Yuxuan; Rosenbaum, Joshua; Eisenberg, Robert A; McGaha, Tracy L; Birkenbach, Mark; Cohen, Philip L (2010. ) A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis.Clinical immunology (Orlando, Fla.), , 136 (2 ) ,236-44 More Information

Shao, Wen-Hai; Zhen, Yuxuan; Eisenberg, Robert A; Cohen, Philip L (2009. ) The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells.Clinical immunology (Orlando, Fla.), , 133 (1 ) ,138-44 More Information

Shao, Wen-Hai; Eisenberg, Robert A; Cohen, Philip L (2008. ) The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950), , 180 (11 ) ,7728-35

Del Prete, Annalisa; Shao, Wen-Hai; Mitola, Stefania; Santoro, Giuseppe; Sozzani, Silvano; Haribabu, Bodduluri (2007. ) Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function.Blood, , 109 (2 ) ,626-31 More Information

Shao, Wen-Hai; Del Prete, Annalisa; Bock, Cheryl B; Haribabu, Bodduluri (2006. ) Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. Journal of immunology (Baltimore, Md. : 1950), , 176 (10 ) ,6254-61

Liao, Tianjiang; Ke, Yan; Shao, Wen-Hai; Haribabu, Bodduluri; Kaplan, Henry J; Sun, Deming; Shao, Hui (2006. ) Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis.Investigative ophthalmology & visual science, , 47 (4 ) ,1543-9 More Information

Jala, Venkatakrishna R; Shao, Wen-Hai; Haribabu, Bodduluri (2005. ) Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.The Journal of biological chemistry, , 280 (6 ) ,4880-7 More Information

Scott, Melanie J; Cheadle, William G; Hoth, J Jason; Peyton, James C; Subbarao, Krishnaprasad; Shao, Wen-Hai; Haribabu, Bodduluri (2004. ) Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice.Clinical and diagnostic laboratory immunology, , 11 (5 ) ,936-41 More Information

Shao, W H; Zhang, X E; Liu, H; Zhang, Z P; Cass, A E Anchor-chain molecular system for orientation control in enzyme immobilization. Bioconjugate chemistry, , 11 (6 ) ,822-6

Zhen, Yuxuan; Lee, Iris J; Finkelman, Fred D; Shao, Wen-Hai (2018. ) Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis.Journal of autoimmunity, , More Information

Zhen, Yuxuan; Finkelman, Fred D; Shao, Wen-Hai (2018. ) Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammation.Journal of leukocyte biology, , 103 (4 ) ,709-717 More Information

Zhen Y.;Shao W.H. (05-24-2019. ) Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages.Journal of visualized experiments : JoVE, , (147 ) , More Information

Zhen, Yuxuan; Smith, Roger D; Finkelman, Fred D; Shao, Wen-Hai (2020. ) Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease.Arthritis research & therapy, , 22 (1 ) ,133 More Information

Cohen, Philip L; Shao, Wen-Hai (2019. ) Gas6/TAM Receptors in Systemic Lupus Erythematosus.Disease markers, , 2019 ,7838195 More Information

Shao, Wen-Hai (2016. ) The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools. Journal of molecular immunology, , 1 (1 ) ,

Zhen, Yuxuan; Ren, Yan; Medvedovic, Mario; Adams, David E; Wang, Diping; Shao, Wen-Hai (2022. ) Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis.Arthritis research & therapy, , 24 (1 ) ,284 More Information

Adams, David E; Zhen, Yuxuan; Qi, Xiaoyang; Shao, Wen-Hai (2022. ) Axl Expression in Renal Mesangial Cells Is Regulated by Sp1, Ap1, MZF1, and Ep300, and the IL-6/miR-34a Pathway.Cells, , 11 (12 ) , More Information

Zhen, Yuxuan; McGaha, Tracy L; Finkelman, Fred D; Shao, Wen-Hai (2022. ) The Akt-mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial cell proliferation.Journal of leukocyte biology, , 111 (3 ) ,563-571 More Information

Adams, David E; Shao, Wen-Hai (2022. ) Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications.Cells, , 11 (3 ) , More Information

Khodoun, Marat V; Morris, Suzanne C; Shao, Wen-Hai; Potter, Crystal; Angerman, Elizabeth; Kiselev, Artem; Yarawsky, Alexander E; Herr, Andrew B; Klausz, Katja; Otte, Anna; Peipp, Matthias; Finkelman, Fred D (2021. ) Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs.The Journal of allergy and clinical immunology, , 147 (5 ) ,1838-1854.e4 More Information

Academic - Wenhai Shao
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-4014
Fax: 513-558-3799
shaowi@ucmail.uc.edu