basic immunology: regulation of cellular, humoral and mocosal immune response. Immunology of infectious diseases: hepatitis, HIV, salmonella, schistosomiasis. Immune regulation in infectious diseases: lymphokines, chemokines. Immunoregulation in HIV and hepatitis C: The roles of chemokines and cytotoxic immune response in HIV and hepatitis C infections. Understanding the immunopathology of Hepatitis E.

Bachelor's Degree: Cairo University, Faculty of Medicine 1978 (Bachelor of Medicine, Bachelor of Surgery )

Master's Degree: Assiut University, Faculty of Medicine Assiut, Egypt, 1983 (Immunology)

Doctoral Degree: University of Maryland, School of Medicine 1989 (Immunology)

Post-doctoral fellowship: University of California 1991 (Immunology)

Study the Immune Responses in Hepatitis and Infectious Diseases, Study Immune Regulation in Different diseases.

1980 -1984 Assistant Lecturer, Teaching medical microbiology and Immunology to medical students, Faculty of Medicine, Assuit University, Assuit, Egypt

1984 -1989 PhD graduate Student, Microbiology Dept., School of Medicine, University of Maryland, Baltimore, Maryland, USA

1991 -1994 Assistant Prof., Teaching medical Microbiology and Immunology to Medical Students. Establishment of Immunology laboratory for research , Microbiology Dept., Faculty of Medicine, Assuit University, Assuit, Egypt

1994 -1997 Associate Professor, Teaching Medical Microbiology and Immunology to medical Students. Initiating and Supervising immunological research projects, Microbiology Dept., Faculty of Medicine, Assuit University, Assuit, Egypt

1997 -2000 Visitor Scientist, Evaluation of the immune responses to recombinant HIV vaccines in animal models, Institution of Human Virology, University of Maryland, Baltimore, Maryland, USA

1989 -1991 Postdoctoral fellow, Evaluation of the regulation of the immune responses in HEL system, Immunology Department, University of California, Los Angeles, California, USA

2000 -2004 Assistant Member, Evaluation of the immune responses in HCV infections , Lindsley Kimball Research Institute, New York Blood Center, New York, USA

2004 -To Present Associate Professor, Head of Viral Immunology Laboratory, Division of Digestive diseases, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

Grant: #1R21 A1067868-01A1 Investigators:Shata, MT 08-15-2006 -07-31-2008 NIH/NIAID Towards understanding the morbidity of HEV infection Role:PI 401,706 Completed Type:Grant Level:National

Grant: #1R01 A1065256 Investigators:Sherman, K. 04-15-2006 -03-31-2011 NIH/NIAID Antiretroviral Therapy and the Hepatitis C Virus Role:Co-PI Active Type:Grant Level:National

Investigators:Giannella R (P.I) and Mohamed Tarek Shata (Co-.PI) 06-10-2009 -06-09-2011 Centocor Research and Development Interleukin 23-dependent Th17 cells in IBD Pathogenesis: a Potential New Marker of Disease Activity Role:Co-PI 160,000 Active Type:Grant Level:National

Investigators:Blackard, J. (P.I.), Shata M.T (Co-investigator) 03-12-2007 -06-11-2008 Bristol-Myers Squibb Characterization of hepatitis B virus in HIV+ patients Role:Co-investigator 180000 Completed Type:Grant

Grant: #Dean's Discovery Fund Investigators:Chougnet, Fichtenbaum, Shata 2005 -2006 University of Cincinnati Evaluation of the effect of low-dose IL-2 immunotherapy on the immune responses in HCV/HIV co-infected patients. Role:P.I. 80,000 Completed Type:Grant

Grant: #DMID Protocol #04-084 Investigators:Cohen (PI) 2005 -2006 NIH, NOI-A1-254559 A randomized, double-blind, Placebo-controlled, dose escalation, inpatient Phase I/II study to determine the safety and immunogenicity of Ty800 in healthy adult subjects. Role:Site PI 100,000 Completed Type:Contract

Grant: #R01 AI41914-01 Investigators:David Hone (PI) 1997 -2001 NIH/NIAID Oral Vaccine-Induced Cellular Immunity against HIV-1 Role:Immunologist (Co-investigator) Completed Type:Grant Level:National

Grant: #R21 AI42603 Investigators:David Hone 1997 -1999 NIH/NIAID Targeted Delivery of Mucosal HIV-1 RNA vaccine Completed Type:Grant Level:National

Grant: #R01 AI38192 Investigators:David Hone (PI) 1998 -2003 NIH/NIAID Immunogenicity of oral SIV & HIV-1 Vaccines in Macaques. Role:Immunologist (Co-Investigator) Completed Type:Grant Level:National

Grant: #NIH KD02573 Investigators:Andrew Talal 2000 -2004 NIH Influence of Immune Status on HCV therapy in HIV/HCV Co-Infected Individuals. Role:Immunologist, consultant Completed Type:Grant Level:National

Grant: #R01 AI47349 Investigators:Alfred Prince (PI) 1999 -2004 NIH/NIAID Prophylactic and Therapeutic DNA-Based Immunization against HCV Completed Type:Grant Level:National

Investigators:Thomas Strickland (PI) 2000 -2005 The Wellcome Trust Evaluation of Protective and Disease-Associated Immunity to Hepatitis C Virus Infection Role:Consultant Immunologist Completed Type:Grant Level:International

Grant: #R21 AI067868 Investigators:Shata, Mohamed Tarek 08-15-2006 -07-31-2009 National Institute of Allergy and Infectious Diseases Towards Understanding the Morbidity of HIV Infection Role:PI $399,926.00 Closed Level:Federal

Investigators:Shata, Mohamed Tarek 06-01-2005 -05-31-2006 National Institute of Allergy and Infectious Diseases Evaluation of FControl Measures Against Infectious Diseases Other than AIDS Role:PI $46,567.00 Closed Level:Federal

Grant: #SRS 004175 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Shire, Norah 03-12-2007 -06-11-2008 Bristol-Myers Squibb Co. Characterization of the Hepatitis B Virus in HIV+ Patients Role:Collaborator $80,994.00 Closed Level:Industry

Grant: #58-3148-1-070 Investigators:Shata, Mohamed Tarek 02-14-2011 -12-31-2013 Department of Agriculture Assessment of the Role of Th17 Cells in the Pathogenesis of Schistosoma Infection in Human Role:PI $66,195.00 Active Level:Federal

Grant: #Merck 38879 Investigators:Shata, Mohamed Tarek; Sherman, Kenneth 03-30-2011 -03-30-2013 Merck Sharp & Dohme Corp Exploring the Role of Gut-associated Th17 in Microbial Translocation in HIV and HCV/HIV Coinfected Patients Role:PI $160,761.00 Closed Level:Industry

Grant: #SRS 007837 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth; Ying, Jun 02-15-2012 -02-15-2014 Merck Sharp & Dohme Corp Evaluating the Role of the Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy Role:PI $231,044.00 Active Level:Industry

Grant: #R01DK108362 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth 09-23-2015 -08-31-2020 National Inst of Diabetes and Digestive and Kidney Disease Hepatitis E in HIV-Infected Patients Role:Collaborator $274,999.00 Awarded Level:Federal

Grant: #R01 AI065256 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth 02-15-2016 -01-31-2020 National Institute of Allergy and Infectious Diseases HIV Antiretroviral Therapy and Hepatic Injury Role:Collaborator $2,124,402.93 Awarded Level:Federal

Grant: #R56 AI065256 Investigators:Blackard, Jason; Shata, Mohamed Tarek; Sherman, Kenneth 07-15-2014 -02-14-2016 National Institute of Allergy and Infectious Diseases Antiretroviral Therapy and Hepatic Injury Role:Collaborator $534,653.00 Closed Level:Federal

Peer Reviewed Publications

Martin, C M; Welge, J A; Shire, N J; Rouster, S D; Shata, M T; Sherman, K E; Blackard, J T (2010. ) Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals.Journal of viral hepatitis, , 17 (8 ) ,588-97 More Information

Subbramanian, Ramu A; Basha, Saleem; Brady, Rebecca C; Hazenfeld, Staci; Shata, Mohamed T; Bernstein, David I (2010. ) Age-related changes in magnitude and diversity of cross-reactive CD4(+) T-cell responses to the novel pandemic H1N1 influenza hemagglutinin.Human immunology, , More Information

Blackard, Jason T; Rouster, Susan D; Nady, Soad; Galal, Gehan; Marzuuk, Naglaa; Rafaat, Marwaa M; Daef, Enas; El Din, Salwa Seif; Purcell, Robert H; Emerson, Suzanne U; Sherman, Kenneth E; Shata, M Tarek (2009. ) Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, , 46 (2 ) ,140-4 More Information

Martin, Christina M; Welge, Jeffrey A; Shire, Norah J; Shata, Mohamed T; Sherman, Kenneth E; Blackard, Jason T (2009. ) Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals.Cytokine, , 47 (3 ) ,194-8 More Information

Nady, Soad; Ignatz-Hoover, James; Shata, Mohamed T (2009. ) Interleukin-12 is the optimum cytokine to expand human Th17 cells in vitro.Clinical and vaccine immunology : CVI, , 16 (6 ) ,798-805 More Information

Atiq, Muslim; Shire, Norah J; Barrett, Anna; Rouster, Susan D; Sherman, Kenneth E; Shata, Mohamed T (2009. ) Hepatitis E virus antibodies in patients with chronic liver disease. Emerging infectious diseases, , 15 (3 ) ,479-81

Youn, Jin-Won; Hu, Yu-Wen; Tricoche, Nancy; Pfahler, Wolfram; Shata, Mohamed Tarek; Dreux, Marlene; Cosset, François-Loic; Folgori, Antonella; Lee, Dong-Hun; Brotman, Betsy; Prince, Alfred M (2008. ) Evidence for protection against chronic hepatitis C virus infection in chimpanzees by immunization with replicating recombinant vaccinia virus.Journal of virology, , 82 (21 ) ,10896-905 More Information

Navaneethan, Udayakumar; Al Mohajer, Mayar; Shata, Mohamed T (2008. ) Hepatitis E and pregnancy: understanding the pathogenesis.Liver international : official journal of the International Association for the Study of the Liver, , 28 (9 ) ,1190-9 More Information

Shata, Mohamed T; Navaneethan, Udayakumar (2008. ) The mystery of hepatitis E seroprevalence in developed countries: is there subclinical infection due to hepatitis E virus?.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 47 (8 ) ,1032-4 More Information

Blackard, Jason T; Shata, M Tarek; Shire, Norah J; Sherman, Kenneth E (2008. ) Acute hepatitis C virus infection: a chronic problem.Hepatology (Baltimore, Md.), , 47 (1 ) ,321-31 More Information

Shata, M T; Barrett, A; Shire, N J; Abdelwahab, S F; Sobhy, M; Daef, E; El-Kamary, S S; Hashem, M; Engle, R E; Purcell, R H; Emerson, S U; Strickland, G T; Sherman, K E (2007. ) Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.Journal of immunological methods, , 328 (1-2 ) ,152-61 More Information

Shata, Mohamed Tarek M; Pfahler, Wolfram; Brotman, Betsy; Lee, Dong-Hun; Tricoche, Nancy; Murthy, Krishna; Prince, Alfred M (2006. ) Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load.Journal of medical primatology, , 35 (3 ) ,165-71 More Information

Yao, Zhi Qiang; Shata, Mohamed Tarek; Tricoche, Nancy; Shan, Mei Mei; Brotman, Betsy; Pfahler, Wolfram; Hahn, Young S; Prince, Alfred M (2006. ) gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection.Virology, , 346 (2 ) ,324-37 More Information

Youn, Jin-Won; Park, Su-Hyung; Lavillette, Dimitri; Cosset, Francois-Loic; Yang, Se-Hwan; Lee, Chang Geun; Jin, Hyun-Tak; Kim, Chang-Min; Shata, Mohamed Tarek M; Lee, Dong-Hun; Pfahler, Wolfram; Prince, Alfred M; Sung, Young Chul (2005. ) Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee.Hepatology (Baltimore, Md.), , 42 (6 ) ,1429-36 More Information

Prince, Alfred M; Brotman, Betsy; Lee, Dong-Hun; Pfahler, Wolfram; Tricoche, Nancy; Andrus, Linda; Shata, Mohamed T (2005. ) Protection against chronic hepatitis C virus infection after rechallenge with homologous, but not heterologous, genotypes in a chimpanzee model.The Journal of infectious diseases, , 192 (10 ) ,1701-9 More Information

Al-Sherbiny, Maged; Osman, Ahmed; Mohamed, Nahla; Shata, Mohamed Tarek; Abdel-Aziz, Fatma; Abdel-Hamid, Mohamed; Abdelwahab, Sayed F; Mikhail, Nabiel; Stoszek, Sonia; Ruggeri, Lionello; Folgori, Antonella; Nicosia, Alfredo; Prince, Alfred M; Strickland, G Thomas (2005. ) Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion. The American journal of tropical medicine and hygiene, , 73 (1 ) ,44-9

Farid, A; Al-Sherbiny, M; Osman, A; Mohamed, N; Saad, A; Shata, M T; Lee, D-H; Prince, A M; Strickland, G T (2005. ) Schistosoma infection inhibits cellular immune responses to core HCV peptides.Parasite immunology, , 27 (5 ) ,189-96 More Information

Sun, Jiaren; Li, Kui; Shata, Mohamed Tarek; Chan, Teh-sheng (2004. ) The immunologic basis for hepatitis C infection. Current opinion in gastroenterology, , 20 (6 ) ,598-602

Prince, A M; Pawlotsky, J-M; Soulier, A; Tobler, L; Brotman, B; Pfahler, W; Lee, D-H; Li, Liping; Shata, M T (2004. ) Hepatitis C virus replication kinetics in chimpanzees with self-limited and chronic infections.Journal of viral hepatitis, , 11 (3 ) ,236-42 More Information

Talal, Andrew H; Shata, M Tarek; Markatou, Marianthi; Dorante, Gary; Chadburn, Amy; Koch, Robert; Neumann, Avidan U; Ribeiro, Ruy M; Perelson, Alan S (2004. ) Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV. Journal of acquired immune deficiency syndromes (1999), , 35 (2 ) ,103-13

Shata, Mohamed Tarek; Shan, Mei Mei; Tricoche, Nancy; Talal, Andrew; Perkus, Marion; Prince, Alfred (2003. ) Optimization of recombinant vaccinia-based ELISPOT assay. Journal of immunological methods, , 283 (1-2 ) ,281-9

Wang, Xinhai; Hone, David M; Haddad, Asmahan; Shata, Mohamed T; Pascual, David W (2003. ) M cell DNA vaccination for CTL immunity to HIV. Journal of immunology (Baltimore, Md. : 1950), , 171 (9 ) ,4717-25

Shata, Mohamed Tarek; Tricoche, Nancy; Perkus, Marion; Tom, Darley; Brotman, Betsy; McCormack, Patricia; Pfahler, Wolfram; Lee, Dong-Hun; Tobler, Leslie H; Busch, Michael; Prince, Alfred M (2003. ) Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees. Virology, , 314 (2 ) ,601-16

Fouts, T R; DeVico, A L; Onyabe, D Y; Shata, M T; Bagley, K C; Lewis, G K; Hone, D M (2003. ) Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1. FEMS immunology and medical microbiology, , 37 (2-3 ) ,129-34

Bagley, K C; Shata, M T; Onyabe, D Y; DeVico, A L; Fouts, T R; Lewis, G K; Hone, D M (2003. ) Immunogenicity of DNA vaccines that direct the coincident expression of the 120 kDa glycoprotein of human immunodeficiency virus and the catalytic domain of cholera toxin. Vaccine, , 21 (23 ) ,3335-41

Shata, M T; Anthony, D D; Carlson, N L; Andrus, L; Brotman, B; Tricoche, N; McCormack, P; Prince, A (2002. ) Characterization of the immune response against hepatitis C infection in recovered, and chronically infected chimpanzees. Journal of viral hepatitis, , 9 (6 ) ,400-10

Agwale, S M; Shata, M T; Reitz, M S; Kalyanaraman, V S; Gallo, R C; Popovic, M; Hone, D M (2002. ) A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (15 ) ,10037-41 More Information

Devico, Anthony L; Fouts, Timothy R; Shata, Mohamed T; Kamin-Lewis, Roberta; Lewis, George K; Hone, David M (2002. ) Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1. Vaccine, , 20 (15 ) ,1968-74

Shata, M T; Reitz, M S; DeVico, A L; Lewis, G K; Hone, D M (2001. ) Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine, , 20 (3-4 ) ,623-9

Prince, A M; Shata, M T (2001. ) Immunoprophylaxis of hepatitis C virus infection. Clinics in liver disease, , 5 (4 ) ,1091-103

Shata, M T; Hone, D M (2001. ) Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8(+) T cells and antiviral protective immunity.Journal of virology, , 75 (20 ) ,9665-70 More Information

Shata, M T; Stevceva, L; Agwale, S; Lewis, G K; Hone, D M (2000. ) Recent advances with recombinant bacterial vaccine vectors. Molecular medicine today, , 6 (2 ) ,66-71

King, C L; Medhat, A; Malhotra, I; Nafeh, M; Helmy, A; Khaudary, J; Ibrahim, S; El-Sherbiny, M; Zaky, S; Stupi, R J; Brustoski, K; Shehata, M; Shata, M T (1996. ) Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. Journal of immunology (Baltimore, Md. : 1950), , 156 (12 ) ,4715-21

King, C L; Hakimi, J; Shata, M T; Medhat, A (1995. ) IL-12 regulation of parasite antigen-driven IgE production in human helminth infections. Journal of immunology (Baltimore, Md. : 1950), , 155 (1 ) ,454-61

Shata, M T; Faltynek, C R; Lewis, G K; Kamin-Lewis, R M (1995. ) Absence of high-affinity binding sites for interferon alpha/beta in variant murine CD4+ T lymphocytes not expressing the T cell antigen receptor. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 15 (4 ) ,291-6

Faltynek, C R; Princler, G L; Schwabe, M; Shata, M T; Lewis, G K; Kamin-Lewis, R M (1990. ) Characterization of the binding of radioiodinated hybrid recombinant IFN-alpha A/D to murine and human lymphoid cell lines. Journal of interferon research, , 10 (1 ) ,55-64

Blackard, Jason T; Ma, Gang; Martin, Christina M; Rouster, Susan D; Shata, M Tarek; Sherman, Kenneth E (2011. ) HIV Variability in the Liver and Evidence of Possible Compartmentalization.AIDS research and human retroviruses, , More Information

Hashem, Mohamed; El-Karaksy, Hanaa; Shata, Mohamed T; Sobhy, Maha; Helmy, Heba; El-Naghi, Suzan; Galal, Gehan; Ali, Zainab Z; Esmat, Gamal; Abdelwahab, Sayed F; Strickland, G Thomas; El-Kamary, Samer S (2011. ) Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children.The Journal of infectious diseases, , 203 (6 ) ,854-61 More Information

Subbramanian, Ramu A; Basha, Saleem; Shata, Mohamed T; Brady, Rebecca C; Bernstein, David I (2010. ) Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination.Vaccine, , 28 (52 ) ,8258-67 More Information

Eldin, Salwa S Seif; Seddik, Ismail; Daef, Enas A; Shata, M T; Raafat, Marwa; Abdel Baky, Laila; Nafeh, M A (2010. ) Risk factors and immune response to hepatitis E viral infection among acute hepatitis patients in Assiut, Egypt. The Egyptian journal of immunology / Egyptian Association of Immunologists, , 17 (1 ) ,73-86

Shata, Mohamed Tarek M; Abdel-Hameed, Enass A; Hetta, Helal F; Sherman, Kenneth E (2013. ) Immune activation in HIV/HCV-infected patients is associated with low-level expression of liver expressed antimicrobial peptide-2 (LEAP-2).Journal of clinical pathology, , 66 (11 ) ,967-75 More Information

Abdel-Hameed, Enass A; Ji, Hong; Sherman, Kenneth E; Shata, Mohamed Tarek M (2013. ) Epigenetic modification of FOXP3 in patients with chronic HIV infection.Journal of acquired immune deficiency syndromes (1999), , More Information

Raza, Ali; Shata, Mohamed T (2013. ) New perspectives of an old cytokine.Inflammatory bowel diseases, , 19 (3 ) ,E39-40 More Information

El-Kamary, Samer S; Hashem, Mohamed; Saleh, Doaa A; Abdelwahab, Sayed F; Sobhy, Maha; Shebl, Fatma M; Shardell, Michelle D; Strickland, G Thomas; Shata, Mohamed Tarek (2013. ) Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus.The Journal of pediatrics, , 162 (1 ) ,148-54 More Information

Martin, C M; Welge, J A; Rouster, S D; Shata, M T; Sherman, K E; Blackard, J T (2012. ) Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.Journal of viral hepatitis, , 19 (10 ) ,716-23 More Information

Shata, Mohamed T; Daef, Enas A; Zaki, Maysaa E; Abdelwahab, Sayed F; Marzuuk, Naglaa M; Sobhy, Maha; Rafaat, Marwa; Abdelbaki, Liala; Nafeh, Mohamed A; Hashem, Mohamed; El-Kamary, Samer S; Shardell, Michelle D; Mikhail, Nabiel N; Strickland, George T; Sherman, Kenneth E (2012. ) Protective role of humoral immune responses during an outbreak of hepatitis E in Egypt.Transactions of the Royal Society of Tropical Medicine and Hygiene, , 106 (10 ) ,613-8 More Information

Kong, Ling; Cardona Maya, Walter; Moreno-Fernandez, Maria E; Ma, Gang; Shata, Mohamed T; Sherman, Kenneth E; Chougnet, Claire; Blackard, Jason T (2012. ) Low-level HIV infection of hepatocytes.Virology journal, , 9 ,157 More Information

Raza, A; Shata, M T (2012. ) Letter: pathogenicity of Th17 cells may differ in ulcerative colitis compared with Crohn's disease.Alimentary pharmacology & therapeutics, , 36 (2 ) ,204; author reply 20 More Information

Raza, Ali; Yousaf, Wajeeha; Giannella, Ralph; Shata, Mohamed Tarek (2012. ) Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease.Expert review of clinical immunology, , 8 (2 ) ,161-8 More Information

Ibrahim, E H; Abdelwahab, S F; Nady, S; Hashem, M; Galal, G; Sobhy, M; Saleh, A S; Shata, M T (2011. ) Prevalence of anti-HEV IgM among blood donors in Egypt. The Egyptian journal of immunology / Egyptian Association of Immunologists, , 18 (2 ) ,47-58

Velilla, P A; Shata, M T; Lages, C S; Ying, J; Fichtenbaum, C J; Chougnet, C (2008. ) Effect of low-dose IL-2 immunotherapy on frequency and phenotype of regulatory T cells and NK cells in HIV/HCV-coinfected patients.AIDS research and human retroviruses, , 24 (1 ) ,52-61 More Information

Hassan, M M; Medhat, A; Makhlouf, M M; Shata, T; Nafeh, M A; Osman, O A; Deaf, E A; Galal, N; Fouad, Y M (1998. ) Detection of circulating antigens in patients with active Schistosoma haematobium infection. The American journal of tropical medicine and hygiene, , 59 (2 ) ,295-301

Medhat, A; Zarzour, A; Nafeh, M; Shata, T; Sweifie, Y; Attia, M; Helmy, A; Shehata, M; Zaki, S; Mikhail, N; Ibrahim, S; King, C; Strickland, G T (1997. ) Evaluation of an ultrasonographic score for urinary bladder morbidity in Schistosoma haematobium infection. The American journal of tropical medicine and hygiene, , 57 (1 ) ,16-9

Blackard, Jason T; Ma, Gang; Sengupta, Satarupa; Martin, Christina M; Powell, Eleanor A; Shata, M Tarek; Sherman, Kenneth E (2014. ) Evidence of distinct populations of hepatitis C virus in the liver and plasma of patients co-infected with HIV and HCV.Journal of medical virology, , 86 (8 ) ,1332-41 More Information

Sherman, K E; Terrault, N; Barin, B; Rouster, S D; Shata, M T (2014. ) Hepatitis E infection in HIV-infected liver and kidney transplant candidates.Journal of viral hepatitis, , 21 (8 ) ,e74-7 More Information

Nady, S; Shata, M T M; Mohey, M A; El-Shorbagy, A (2017. ) Protective role of IL-22 against Schistosoma mansoni soluble egg antigen-induced granuloma in Vitro.Parasite immunology, , 39 (1 ) , More Information

Mehta, Minesh; Hetta, Helal F; Abdel-Hameed, Enass A; Rouster, Susan D; Hossain, MdMonir; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; El-Mokhtar, Mohamed A; Abdelwahab, Sayed F; Medhat, Ahmed; Sherman, Kenneth E; Shata, Mohamed Tarek M (2016. ) Association between IL28B rs12979860 single nucleotide polymorphism and the frequency of colonic Treg in chronically HCV-infected patients.Archives of virology, , 161 (11 ) ,3161-9 More Information

Hetta, Helal F; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; Medhat, Ahmed; Nassar, Mahmoud I; Sherman, Kenneth E; Shata, Mohamed Tarek M (2016. ) Extra-hepatic infection of hepatitis C virus in the colon tissue and its relationship with hepatitis C virus pathogenesis.Journal of medical microbiology, , 65 (8 ) ,703-12 More Information

Abdel-Hameed, Enass A; Rouster, Susan D; Ji, Hong; Ulm, Ashley; Hetta, Helal F; Anwar, Nadeem; Sherman, Kenneth E; Shata, Mohamed Tarek M (2016. ) Evaluating the Role of Cellular Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy.Viral immunology, , 29 (4 ) ,252-8 More Information

Abdel-Hameed, Enass A; Ji, Hong; Shata, Mohamed Tarek (2016. ) HIV-Induced Epigenetic Alterations in Host Cells.Advances in experimental medicine and biology, , 879 ,27-38 More Information

Hetta, Helal F; Mekky, Mohamed A; Khalil, Nasr K; Mohamed, Wegdan A; El-Feky, Mohamed A; Ahmed, Shabaan H; Daef, Enas A; Nassar, Mahmoud I; Medhat, Ahmed; Sherman, Kenneth E; Shata, Mohamed Tarek M (2015. ) Association of colonic regulatory T cells with hepatitis C virus pathogenesis and liver pathology.Journal of gastroenterology and hepatology, , 30 (10 ) ,1543-51 More Information

Sherman, Kenneth E; Guedj, Jeremie; Shata, Mohamed Tarek; Blackard, Jason T; Rouster, Susan D; Castro, Mario; Feinberg, Judith; Sterling, Richard K; Goodman, Zachary; Aronow, Bruce J; Perelson, Alan S (2014. ) Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients.Science translational medicine, , 6 (246 ) ,246ra98 More Information

Shata, Mohamed Tarek M; Abdel-Hameed, Enass A; Rouster, Susan D; Yu, Li; Liang, Meina; Song, Esther; Esser, Mark T; Shire, Norah; Sherman, Kenneth E (2019. ) HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles.Pathogens & immunity, , 4 (1 ) ,39-65 More Information

Sherman, Kenneth E; Abdel-Hameed, Enass; Rouster, Susan D; Shata, Mohamed Tarek M; Blackard, Jason T; Safaie, Parham; Kroner, Barbara; Preiss, Liliana; Horn, Paul S; Kottilil, Shyam (2018. ) Improvement in Hepatic Fibrosis Biomarkers Associated with Chemokine Receptor Inactivation through Mutation or Therapeutic Blockade.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , More Information

Sherman, Kenneth E; Rouster, Susan D; Kong, Ling X; Shata, Tarek M; Archampong, Timothy; Kwara, Awewura; Aliota, Matthew T; Blackard, Jason T (2018. ) Zika Virus Exposure in an HIV-Infected Cohort in Ghana.Journal of acquired immune deficiency syndromes (1999), , 78 (5 ) ,e35-e38 More Information

Moon, Changsuk; Zhang, Weiqiang; Ren, Aixia; Arora, Kavisha; Sinha, Chandrima; Yarlagadda, Sunitha; Woodrooffe, Koryse; Schuetz, John D; Valasani, Koteswara Rao; de Jonge, Hugo R; Shanmukhappa, Shiva Kumar; Shata, Mohamed Tarek M; Buddington, Randal K; Parthasarathi, Kaushik; Naren, Anjaparavanda P (2015. ) Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.The Journal of biological chemistry, , 290 (18 ) ,11246-57 More Information

Nady, Soad; Ezz, Asmaa; El-Shorbagy, Ayatollah; Esmat, Gamal; Mt, Shata (2016. ) HCV Infection Amplified Th2 Bias and Th17 Responses In Schistosoma-Infected Patients. The Egyptian journal of immunology, , 23 (1 ) ,87-96

Blackard, Jason T; Kong, Ling; Rouster, Susan D; Karns, Rebekah; Horn, Paul S; Kottilil, Shyam; Shata, M Tarek; Sherman, Kenneth E (2019. ) CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro.PloS one, , 14 (10 ) ,e0224523 More Information

Kong, Ling; Karns, Rebekah; Shata, Mohamed Tarek M; Brown, Jennifer L; Lyons, Michael S; Sherman, Kenneth E; Blackard, Jason T (2021. ) The synthetic opioid fentanyl enhances viral replication in vitro.PloS one, , 16 (4 ) ,e0249581 More Information

Sherman, Kenneth E; Kottilil, Shyam; Rouster, Susan D; Abdel-Hameed, Enass A; Boyce, Ceejay L; Meeds, Heidi L; Terrault, Norah; Shata, M Tarek (2021. ) Hepatitis E Infection in a Longitudinal Cohort of HCV and HCV/HIV Coinfected Persons.AIDS research and human retroviruses, , More Information

Kong, Ling; Karns, Rebekah; Shata, Mohamed Tarek M; Brown, Jennifer L; Lyons, Michael S; Sherman, Kenneth E; Blackard, Jason T (2021. ) The synthetic opioid fentanyl enhances viral replication in vitro.PloS one, , 16 (4 ) ,e0249581 More Information

Sherman, Kenneth E; Kottilil, Shyam; Rouster, Susan D; Abdel-Hameed, Enass A; Boyce, Ceejay L; Meeds, Heidi L; Terrault, Norah; Shata, M Tarek (2021. ) Hepatitis E Infection in a Longitudinal Cohort of HCV and HCV/HIV Coinfected Persons.AIDS research and human retroviruses, , More Information

Book Chapter

Shire NJ, Blackard JT, Shata MT, and Sherman KE (2007 ) Occult Hepatitis B Virus: Epidemiologic, Virologic, and Immunologic Characteristics. Progress in Hepatitis B Research .(pp. 1 -36).New York, Nova Science Publishers, Inc (Co-Author)

Hone DM, Shata, MT, Pascual DW, and Lewis GK (1999 ) Mucosal vaccination with Salmonella vaccine vectors Intracellular Bacterial Vaccine Vectors: Immunology, Cell Biology and Genetics. (pp. 171 -222).New York, J. Wiley and Sons (Co-Author)

Shata MT In HIV and Liver diseases, Springer, New York, NY, Chapter 7, Pp. 55-65, DOI 10.1007/978-1-4419-1712-6 (2011 ) Immunopathology of liver injury. HIV and Liver diseases .(pp. 55 -65).New York, Springer (Author)

Invited Presentations

Mohamed Tarek M. Shata (2009. ) (In Press. ) The mystery of hepatitis E in developed and developing countries .Medical Challenge Beyond the Millenium, Abu Dhabi, UAE. Conference. . Level:International

Mohamed Tarek M. Shata (04-11-2009. ) (In Progress. ) Immunolgy of viral hepatitis . Touro University Nevada. Other Institution. . Level:National

Mohamed Tarek Shata (10-15-2008. ) (In Press. ) Hepatitis E in Egypt, is it a problem? .5th Symposium "Liver Diseases at crossroads of civilizations: East meets West", Alexandria, Egypt. Conference. . Level:International

Poster Presentations

Mohamed Tarek M Shata, Jason T Blackard, Naglaa M Marzuuk, Marwa Rafaat, Maha Sobhy, Gehan Galal, Kwenyerchi P Onourah, Sayed F Abdelwahab, Enas Deaf, Maysaa E Zaki, MD, Samer El-Kamary, Mohamed Hashem, Nabiel N Mokhail, Thomas G Strickland, and Kenneth E Sherman. (03-20-2009. ) (In Press. ) Comparison of Cell-Mediated Immune Responses in Symptomatic and Asymptomatic HEV Infections in Egyp .13th International Symposium on Viral Hepatitis and Liver Disease, Washington DC. . Professional Meeting. . Level:International

Mohamed Tarek M. Shata, Anna Barrett, Susan D. Rouster, Norah J. Shire, Jason Blackard , Muslim Atiq, Ronald Engle, Robert Purcell , Suzanne Emerson, Thomas Strickland, and Kenneth E. Sherman (01-07-2008. ) (In Press. ) Isolation and characterization of hepatitis E virus (HEV)-specific T cell clones from an asymptomatic HEV-exposed subject. 12th International Symposium on Viral Hepatitis and Liver Disease, Paris. . Professional Meeting. . Level:International

Shata MT,Velilla PA, Chougent C, Ying Y, and Fichtenbaum C (09-15-2006. ) (In Press. ) Evaluating the effect of Low-Dose IL-2 immunotherapy on the immune response in HCV/HIV-coinfected patients .HIV & Liver Diseases, Jackson Hole, Wyoming. . Professional Meeting. . Level:International

Hashem M, El-Kamary S S, El-Karaksy H, Helmy H, Abdel Wahab ‎‎SF , El-Naghi S, Sobhy M, Galal G, Zakaria Z, Fathy E, Shata M.T, Esmat G, Strickland G.T (10-05-2008. ) (In Press. ) CELL MEDIATED IMMUNITY IN SERONEGATIVE AVIREMIC CHILDREN WITH INTRAFAMIAL EXPOSURE TO HEPATITIS C VIRUS .15th International Symposium on hepatitis C virus & related viruses, San Antonio, Texas, USA. . Conference. . Level:International

Hashem M, El-Kamary SS, El-Karaksy H, Helmy H, Abdel Wahab ‎‎SF , El-Naghi S, Sobhy M, Galal G, Zakaria Z, Galal I, Shata MT, Esmat G7, Strickland G.T. (10-05-2008. ) (In Press. ) Cell Mediated Immunity in Seronegative Aviremic Children With Intrafamilial Exposure to Hepatitis C Virus .15th International Symposium on hepatitis C & Related viruses, San Antonio, Texas. . Conference. . Level:International

Sherman KE, Rouster SD, Bini EJ, Blackard JT, Shata MT (02-08-2009. ) (In Press. ) Hepatic Apoptosis Following Initiation of Antiretroviral Therapy in HCV/HIV Coinfected Subjects .16th Conference on Retorviruses and Opportunistic Infections, Montreal, Canada. . Conference. . Level:International

Jason T. Blackard, Gang Ma, Susan D. Rouster, Anna Barrett, M. Tarek Shata, and Kenneth E. Sherman (06-04-2009. ) (In Press. ) HIV is frequently detected in liver biopsy tissue .5th International HIV and Hepatitis Co-infection Workshop, Lisbon, Portugal. . Workshop. . Level:International

Shata M. T., Navaneethan U., Marzuuk N.M, Rafaat M., Daef E., Zaki M.E., Sadek I.; Abdel baky L. , Nafeh M.A. , Hashem M. ,El-Kamary S., Mikhail, N.N.; Strickland G.T., Sherman K.E (03-20-2009. ) (In Press. ) Epidemiological and clinical study of sporadic acute hepatitis E in Egypt in comparison to other hepatitis viruses .13th International Symposium on Viral Hepatitis and Liver Diseases, Washington DC, USA. . Professional Meeting. . Level:International

Jason T. Blackard, Susan D. Rouster, Soad Nady, Gehan Galal, Naglaa Marzuuk, Marwaa M. Rafaat, Enas Daef, Salwa Seif El Din , Robert H. Purcell, Suzanne U. Emerson, Kenneth E. Sherman, and M. Tarek Shata (03-20-2009. ) (In Press. ) Genotypic characterization of symptomatic hepatitis E virus (HEV) infection in Egypt .13th International Symposium on Viral Hepatitis and Liver Diseases, Washington DC. . Professional Meeting. . Level:International

James Ignatz-Hoover, Soad Nady, Mohamed T Shata (08-07-2009. ) (In Press. ) Properties of Th17 Cells In Vitro .7th poster session for undergraduates , Cincinnati, OH. . UC. . Level:University

Shata MT, Bartholomew KA, Rouster SD, Blackard JT, Sterling RK, Bini E, Perelson AS, Goodman ZD and Sherman KE (2010. ) (In Progress. ) Strong HCV and HIV Immune Responses in Coinfected Subjects Who Experienced ALT Flare and/or Rebound HCV Viral Load After ART Initiation .CRIO 2010, San Francisco. . Conference. . Level:International

1984 -1989 Peace PhD Scholarship PhD Scholarship from Egyptian Ministry of High Education and USAID. Status:Recipient Level:International Type:Fellowship

1991 -1996 Schistosoma Research Project (SRP) SRP grant to study the immune responses in Schistosoma infection in Egypt funded by the Egyptian Ministry of Health and USAID Status:Recipient Level:National Type:Grant

Mohamed Sad Badary (Doctoral ) Advisor Status:Completed 1994

Yousef Khadir (Doctoral ) Supervisor Status:Completed 1994

Ahmed Helmy (Master ) Supervisor Status:Completed 1993

Soad Nady Ibrahim (Postdoctoral ) Supervisor Status:Completed 2008

James Ignatz-Hoover1 (Undergrad ) Supervisor Status:Completed 08-2009

Maha Sobhy (Doctoral ) Committee Member Status:In Progress

Muslim Atiq (Other ) Lab Rotation Preceptor Status:Completed 2007

Udhay Navaneethan (Other ) Advisor Status:In Progress

Yunguan Wang (Master ) Lab Rotation Preceptor Status:In Progress 2010

University of Cincinnati, Medical School ( Admission Committee to the medical School ) Committee Member Type:University/College Service Level:College 2007 -2009

University of Cincinnati (Research Committee of the Internal Medicine ) Committee Member Type:Departmental Service Level:University 2007 -To Present

Division of Digestive diseases (Research Committee of the Division of the Digestive Diseases ) Committee Member Type:Departmental Service Level:Department 2008 -To Present

Journal of Viral hepatitis Reviewer Type:Editorial Service Level:International 2004 -To Present

Infection and Immunity Reviewer Type:Editorial Service Level:International 2003 -To Present

J of Virology Reviewer Type:Editorial Service Level:International 2003 -To Present

Journal of Hepatology Reviewer Type:Editorial Service Level:International 2002 -To Present

Vaccines Outside Reviewer Type:Editorial Service Level:International 2004 -To Present

Clinical and Diagnostic Laboratory Immunology (CDLI) Outside Reviewer Type:Editorial Service Level:International 2003 -To Present

Journal of Clinical Microbiology (JCM) Outside Reviewer Type:Editorial Service Level:International 2006 -To Present

Clinical and Vaccine Immunology (CVI) Outside Reviewer Type:Editorial Service Level:International 2005 -To Present

Journal of Infectious Diseases (JID) Outside Reviewer Type:Editorial Service Level:International 2004 -To Present

Transactions of the Royal Society of Tropical Medicine & Hygiene Outside Reviewer Type:Editorial Service Level:International 2005 -To Present

immunity, immunology, T cells, hepatitis C, HCV, hepatitis

2001 -To Present: Member of American Society of Microbiology ASM, Washington DC, USA

2008 -To Present: member of American Gastroenterological Association (AGA) American Gastroenterological Association (AGA), USA

2000 -2003: member of American Society of Tropical Medicine and Hygiene American Society of Tropical Medicine and Hygiene, USA

1995 -1998: member of International Union of Immunological Societies (IUIS) International Union of Immunological Societies (IUIS),

2005 -2006: Reviewer of Wellcome Trust grants Wellcome Trust, UK

2006 -2008: Reviewer for the Center for Special Studies and Programs (CSSP), Bibliotheca Alexandrina (BA). Bibliotheca Alexandrina (BA), Alexandria, Egypt

2009: reviewer for NIH ACE and ZRG1 BBBP-J challenge grants study sections NIH, Bethesda, MD, USA

2009 -2009: NIH reviewer 2009 reviewer for NIH ACE and ZRG1 AARR-H 22L AIDS Predoctoral and Postdoctoral fellowship study sections NIH Bethesda, MD, USA NIH, Bethesda, MD, USA

1990 -To Present: Ad hoc reviewer 1990 to Present Reviewers a. J. of Viral hepatitis b. Infection and immunity c. J. of Hepatology d. J. of Virology e. Vaccine f. Clinical and Diagnostic Laboratory Immunology (CDLI) g. Journal of Clinical Microbiology (JCM) h. Clinical and Vaccine Immunology (CVI) i. Journal of Infectious Diseases (JID) j. Transactions of the Royal Society of Tropical Medicine & Hygiene k. Cellular Physiology and Biochemistry

2009 -2010: Reviewer for grants for the National Medical Research Council (NMRC), Singapore National Medical Research Council (NMRC), Singapore

15-BIOL-551 GENERAL MICROBIOL Level:Undergraduate

15-BIOL-597 MOLEC MICROBIOLOGY Level:Undergraduate

Immunocytochemistry Level:Undergraduate

Regulatory Immunology Level:Undergraduate

Fundamental immunology and its applications to the study of Schistosomiasis Level:Graduate

2005-2007 Immunology of Diseases Level:Graduate

Immunology of hepatitis viruses Level:Graduate

Immunology of vaccines Level:Graduate